R. Mortishire-Smith

发表

The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage λ repressor DNA-binding domain

P. Wright, W. Herr, N. Assa‐Munt, 1993, Cell.

'All-in-one' analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching.

Mark Wrona, Desmond O'Connor, Kevin P Bateman, 2005, Rapid communications in mass spectrometry : RCM.

NMR spectroscopic-based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats.

Jeremy K Nicholson, Andrew W Nicholls, R. Mortishire-Smith, 2003, Chemical research in toxicology.

Length preferences and periodicity in beta-strands. Antiparallel edge beta-sheets are more likely to finish in non-hydrogen bonded rings.

P. Dobson, A. Doig, S. Penel, 2003, Protein engineering.

Length preferences and periodicity in β‐strands. Antiparallel edge β‐sheets are more likely to finish in non‐hydrogen bonded rings

P. Dobson, A. Doig, S. Penel, 2003 .

Structural determinants of Cys2His2 zinc fingers

P. Wright, R. Mortishire-Smith, L. Bolinger, 1992, FEBS letters.

Temperature calibration of a high‐resolution magic‐angle spinning NMR probe for analysis of tissue samples

R. Mortishire-Smith, A. Nicholls, 2001 .

A proteomic investigation of drug-induced steatosis in rat liver.

R. Mortishire-Smith, G. Meneses‐Lorente, I. Cristea, 2004, Chemical research in toxicology.

Use of metabonomics to identify impaired fatty acid metabolism as the mechanism of a drug-induced toxicity.

Jeremy K Nicholson, Andrew W Nicholls, Bruce A. Johnson, 2004, Chemical research in toxicology.

Profiling of the known-unknown Passiflora variant complement by liquid chromatography - Ion mobility - Mass spectrometry.

R. Mortishire-Smith, J. Vissers, D. Eatough, 2021, Talanta.

Metabolite Identification Using An Ion Mobility-Enhanced Data-Independent Acquisition Strategy and Automated Data Processing.

R. Mortishire-Smith, I. Zamora, M. Wrona, 2020, Rapid communications in mass spectrometry : RCM.

Extracting metabolite ions out of a matrix background by combined mass defect, neutral loss and isotope filtration.

R. Mortishire-Smith, J. Castro-Pérez, L. Leclercq, 2009, Rapid communications in mass spectrometry : RCM.

Development and Validation of a Higher-Throughput Equilibrium Dialysis Assay for Plasma Protein Binding

Russell Mortishire-Smith, R. Mortishire-Smith, S. van Liempd, 2011, Journal of laboratory automation.

Simultaneous quantitation of two diastereoisomers of lobaplatin in rat plasma by supercritical fluid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study.

R. Mortishire-Smith, J. Gu, Meiyun Shi, 2015, Journal of separation science.

4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors

Euan R. Kay, R. Mortishire-Smith, Michael A. Reilly, 2006 .

Strategies for data analyses in a high resolution 1H NMR based metabolomics study of a mouse model of Batten disease

R. Mortishire-Smith, J. Griffin, J. Cooper, 2007, Metabolomics.

Structure determination of tolaasin, an extracellular lipodepsipeptide produced by the mushroom pathogen, Pseudomonas tolaasii Paine

Dudley H. Williams, R. Mortishire-Smith, P. Rainey, 1991 .

Determination of the structure of an extracellular peptide produced by the mushroom saprotroph pseudomonas reactans

Dudley H. Williams, R. Mortishire-Smith, P. Rainey, 1991 .

The zinc finger motif Conservation of chemical shifts and correlation with structure

P. Wright, R. Mortishire-Smith, M. Lee, 1992, FEBS letters.

Profiling of hepatic clearance pathways of Pittsburgh compound B and human liver cytochrome p450 phenotyping

Mark E. Schmidt, X. Langlois, R. Mortishire-Smith, 2013, EJNMMI Research.

Left handed alpha-helix formation by a bacterial peptide.

R. Mortishire-Smith, D. Williams, A. Drake, 1991, FEBS letters.

Synthesis and conformational dynamics of tricyclic pyridones containing a fused seven-membered ring.

R. Mortishire-Smith, A. Nadin, U. Gerhard, 2002, The Journal of organic chemistry.

2,7-diazabicyclo[3.3.0]octanes as novel h5-HT receptor agonists.

R. Mortishire-Smith, M. Beer, J. Stanton, 1999, Bioorganic & medicinal chemistry letters.

High-throughput bioanalysis with simultaneous acquisition of metabolic route data using ultra performance liquid chromatography coupled with time-of-flight mass spectrometry

R. Mortishire-Smith, D. O'connor, 2006, Analytical and bioanalytical chemistry.

Molecular recognition by secondary metabolites.

R. Mortishire-Smith, D. Williams, M. Stone, 1990, Biochemical pharmacology.

Isolation and characterisation of a C18 neutral steroid, oestra-5(10),7-diene-3,17-diol, from pregnant mare urine and allantoic fluid. Facile oxidation to yield oestra-5(10),6,8-triene-3,17-diol (diol of Heard's ketone)

R. Mortishire-Smith, D. B. Gower, E. Houghton, 2000, The Journal of Steroid Biochemistry and Molecular Biology.

Ultra-performance liquid chromatography coupled to time-of-flight mass spectrometry for robust, high-throughput quantitative analysis of an automated metabolic stability assay, with simultaneous determination of metabolic data.

Desmond O'Connor, Russell Mortishire-Smith, Amy Davies, 2006, Rapid communications in mass spectrometry : RCM.

The toxicity in vitro of beta-amyloid protein.

L. Iversen, R. Mortishire-Smith, S. Pollack, 1995, The Biochemical journal.

A Comparative Study Using Preparative Reverse Phase Liquid Chromatography and Supercritical Fluid Chromatography of Impurities from a Stressed Pharmaceutical Drug Substance : Waters

R. Mortishire-Smith, Jayne M Kirk, J. Hammond, 2020 .

Evaluation of Three State-of-the-Art Metabolite Prediction Software Packages (Meteor, MetaSite, and StarDrop) through Independent and Synergistic Use

K Boussery, H T'jollyn, R J Mortishire-Smith, 2011, Drug Metabolism and Disposition.

Microsoft Word-65641837-file00.docx

R. Mortishire-Smith, K. Boussery, B. De Boeck, 2011 .

A metabolomic comparison of mouse models of the Neuronal Ceroid Lipofuscinoses

R. Salek, R. Mortishire-Smith, J. Griffin, 2011, Journal of biomolecular NMR.

Deletion of btn1, an orthologue of CLN3, increases glycolysis and perturbs amino acid metabolism in the fission yeast model of Batten disease.

R. Mortishire-Smith, J. Griffin, Sandra Codlin, 2010, Molecular bioSystems.

High Resolution 1H NMR-based Metabolomics Indicates a Neurotransmitter Cycling Deficit in Cerebral Tissue from a Mouse Model of Batten Disease*

Julian L Griffin, Jonathan D Cooper, R. Mortishire-Smith, 2005, Journal of Biological Chemistry.

Delineation of the Structural Determinants of the N‐Methyl‐D‐Aspartate Receptor Glycine Binding Site

R. Mortishire-Smith, P. Whiting, S. Grimwood, 1999, Journal of neurochemistry.

Metabolomic investigation of CLN6 neuronal ceroid lipofuscinosis in affected South Hampshire sheep

R. Salek, R. Mortishire-Smith, J. Griffin, 2007, Journal of neuroscience research.

Integrating Ion Mobility into Routine Drug Metabolite Identification Studies Using the Vion IMS QTof Mass Spectrometer

R. Mortishire-Smith, M. Wrona, Jayne M Kirk, 2017 .

A Functional Analysis of Mouse Models of Cardiac Disease through Metabolic Profiling*

Kieran Clarke, Julian L Griffin, Brian C Sweatman, 2005, Journal of Biological Chemistry.

Automated assignment of high‐resolution collisionally activated dissociation mass spectra using a systematic bond disconnection approach

R. Mortishire-Smith, Alastair Hill, Russell J. Mortishire-Smith, 2005 .

Metabolite identification in drug discovery.

R. Mortishire-Smith, U. Gerhard, Russell J Mortishire-Smith, 2003, Current opinion in drug discovery & development.

Structure Determination of Tolaasin, an Extracellular Lipodepsipeptide Produced by the Mushroom Pathogen Pseudomonas tolaasii Paine.

Dudley H. Williams, R. Mortishire-Smith, P. Rainey, 1991 .

Solution structure of the cytoplasmic domain of phopholamban: phosphorylation leads to a local perturbation in secondary structure.

R J Mortishire-Smith, R. Mortishire-Smith, V. Garsky, 1995, Biochemistry.

Periodicity in alpha-helix lengths and C-capping preferences.

R J Mortishire-Smith, A. Doig, S. Penel, 1999, Journal of molecular biology.

Product ion mobility as a promising tool for assignment of positional isomers of drug metabolites.

G. Tresadern, R. Mortishire-Smith, C. Wassvik, 2011, Rapid communications in mass spectrometry : RCM.

Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT(1A) and 5-HT re-uptake ligands.

R. Mortishire-Smith, D. O'connor, D. C. Evans, 1999, Bioorganic & medicinal chemistry letters.

Structural Studies on Phospholamban and Implications for Regulation of the Ca2+‐ATPase

R. Mortishire-Smith, V. Garsky, E. J. Mayer, 1998, Annals of the New York Academy of Sciences.

High‐Resolution Mass Spectrometry and Drug Metabolite Identification

R. Mortishire-Smith, K. Bateman, Haiying Zhang, 2011 .

Enhancing Analysis Specificity and Deconvolution of Natural Products Using a Positive-Mode, Ion-Mobility, Mass Spectrometry Library

R. Mortishire-Smith, M. McCullagh, 2019 .

Accelerated metabolite identification by "extraction-NMR".

Steven Thomas, Russell Mortishire-Smith, R. Mortishire-Smith, 2003, Journal of pharmaceutical and biomedical analysis.

Identification of metabolites of a substance P (neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma.

R. Mortishire-Smith, U. Gerhard, Sanjeev Kumar, 2002, Drug Metabolism And Disposition.

Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis.

Desmond O'Connor, R. Mortishire-Smith, D. O'connor, 2005, Rapid communications in mass spectrometry : RCM.

Generic dealkylation: a tool for increasing the hit-rate of metabolite rationalization, and automatic customization of mass defect filters.

M. Hartshorn, R. Mortishire-Smith, J. Castro-Pérez, 2009, Rapid communications in mass spectrometry : RCM.

Left handed α‐helix formation by a bacterial peptide

Dudley H. Williams, R. Mortishire-Smith, A. Drake, 1991 .

A Comparative Study Using Preparative Reverse Phase Liquid Chromatography and Supercritical Fluid Chromatography of Impurities from a Stressed Pharmaceutical Drug Substance

R. Mortishire-Smith, C. Howson, Jayne M Kirk, 2018 .

IsoScore: automated localization of biotransformations by mass spectrometry using product ion scoring of virtual regioisomers.

M. Hartshorn, R. Mortishire-Smith, L. Leclercq, 2009, Rapid communications in mass spectrometry : RCM.

Structure elucidation and solution conformation of the glycopeptide antibiotic ramoplanose (UK-71,903): a cyclic depsipeptide containing an antiparallel .beta.-sheet and a .beta.-bulge

Dudley H. Williams, R. Mortishire-Smith, M. Rance, 1991 .

Structure Elucidation and Solution Conformation of the Glycopeptide Antibiotic Ramoplanose (UK‐71,903): A Cyclic Depsipeptide Containing an Antiparallel β‐Sheet and a β‐Bulge.

Dudley H. Williams, R. Mortishire-Smith, M. Rance, 1992 .

Metabolic profiling of rodent biological fluids via 1H NMR spectroscopy using a 1 mm microlitre probe.

R. Mortishire-Smith, J. Griffin, J. Nicholson, 2002, The Analyst.

Investigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration

R. Mortishire-Smith, I. Wilson, R. Plumb, 2023, Xenobiotica; the fate of foreign compounds in biological systems.

Conserved positioning of proline residues in membrane-spanning helices of ion-channel proteins.

R. Mortishire-Smith, D. Woolfson, D. Williams, 1991, Biochemical and biophysical research communications.

4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors.

R. Mortishire-Smith, Michael A. Reilly, E. Kay, 2006, Bioorganic & medicinal chemistry letters.

IsoScore: automated localization of biotransformations by mass spectrometry using product ion scoring of virtual regioisomers.

M. Hartshorn, R. Mortishire-Smith, L. Leclercq, 2009, Rapid communications in mass spectrometry : RCM.