S. Mandlekar

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Induction of apoptosis and activation of interleukin 1beta-converting enzyme/Ced-3 protease (caspase-3) and c-Jun NH2-terminal kinase 1 by benzo(a)pyrene.

W. Lei, R. Yu, S. Mandlekar, 1998, Cancer research.

Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro

A. D. Rodrigues, M. Matta, S. Mandlekar, 2016, Drug Metabolism and Disposition.

Unmasking the Role of Uptake Transporters for Digoxin Uptake Across the Barriers of the Central Nervous System in Rat

S. Mandlekar, P. Marathe, Kunal S. Taskar, 2017, Journal of central nervous system disease.

Coproporphyrin-I: A Fluorescent, Endogenous Optimal Probe Substrate for ABCC2 (MRP2) Suitable for Vesicle-Based MRP2 Inhibition Assay

S. Mandlekar, Y. Lai, Sagnik Chatterjee, 2017, Drug Metabolism and Disposition.

Coproporphyrins in Plasma and Urine Can Be Appropriate Clinical Biomarkers to Recapitulate Drug-Drug Interactions Mediated by Organic Anion Transporting Polypeptide Inhibition

W. Humphreys, S. Mandlekar, P. Marathe, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models

S. Mandlekar, P. Marathe, S. Singh, 2015, Biopharmaceutics & drug disposition.

Metabolite Identification, Reaction Phenotyping, and Retrospective Drug-Drug Interaction Predictions of 17-Deacetylnorgestimate, the Active Component of the Oral Contraceptive Norgestimate

S. Mandlekar, S. Sinha, R. Iyer, 2017, Drug Metabolism and Disposition.

Relative quantitation of endogenous proteins by quadrupole-time of flight and tandem mass spectrometry.

S. Mandlekar, P. Kole, Murali Subramanian, 2019, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Insight into tissue unbound concentration: utility in drug discovery and development.

S. Mandlekar, P. Marathe, T. Mariappan, 2013, Current drug metabolism.

Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells.

R. Yu, S. Mandlekar, A. Kong, 2000, Cancer research.

Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity.

R. Yu, S. Mandlekar, A. Kong, 1998, Cancer research.

A modified serial blood sampling technique and utility of dried-blood spot technique in estimation of blood concentration: application in mouse pharmacokinetics

Ravi Kumar Trivedi, S. Mandlekar, R. Trivedi, 2011, European Journal of Drug Metabolism and Pharmacokinetics.

LC-MS determination of triazolam and its hydroxy metabolites in mouse dried blood spots: application to transgenic mouse pharmacokinetic studies.

S. Mandlekar, P. Kole, Vishwanath Kurawattimath, 2017, Bioanalysis.

Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects

W. Humphreys, S. Mandlekar, P. Marathe, 2017, Drug Metabolism and Disposition.

Estimation of the unbound brain concentration of P-glycoprotein substrates or nonsubstrates by a serial cerebrospinal fluid sampling technique in rats.

S. Mandlekar, P. Marathe, Kunal S. Taskar, 2014, Molecular pharmaceutics.

(Carbonyl)oxyalkyl linker-based amino acid prodrugs of the HIV-1 protease inhibitor atazanavir that enhance oral bioavailability and plasma trough concentration.

Murugaiah A. M. Subbaiah, S. Mandlekar, N. Meanwell, 2020, European journal of medicinal chemistry.

p38 Mitogen-activated Protein Kinase Negatively Regulates the Induction of Phase II Drug-metabolizing Enzymes That Detoxify Carcinogens*

R. Yu, S. Mandlekar, A. Kong, 2000, The Journal of Biological Chemistry.

Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in androgen-independent prostate cancer cells.

R. Yu, S. Mandlekar, A. Kong, 2000, Cancer research.

Expression and Characterization of Cynomolgus Monkey Cytochrome CYP 3 A 4 in a Novel Human Embryonic Kidney Cell – Based Mammalian System s

A. D. Rodrigues, S. Mandlekar, K. Ghosh, 2014 .

Expression and Characterization of Cynomolgus Monkey Cytochrome CYP3A4 in a Novel Human Embryonic Kidney Cell–Based Mammalian System

A. D. Rodrigues, S. Mandlekar, K. Ghosh, 2014, Drug Metabolism and Disposition.

Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways.

J. Pezzuto, R. Yu, S. Mandlekar, 2001, Molecular pharmacology.

Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists.

Michael G. Yang, J. Barrish, S. Mandlekar, 2014, Bioorganic & medicinal chemistry letters.

Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists.

D. J. Nelson, S. Mandlekar, P. Scherle, 2008, Journal of medicinal chemistry.

Expression and characterization of cynomolgus monkey cytochrome CYP 3 A 4 in a novel human embryonic kidney ( HEK 293 ) cell based mammalian system

A. D. Rodrigues, S. Mandlekar, K. Ghosh, 2013 .

Selective Inhibition of Eosinophil Influx into the Lung by Small Molecule CC Chemokine Receptor 3 Antagonists in Mouse Models of Allergic Inflammation

K. McIntyre, S. Mandlekar, J. Trzăskos, 2006, Journal of Pharmacology and Experimental Therapeutics.

Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2.

Michael G. Yang, S. Mandlekar, A. Mathur, 2021, ACS medicinal chemistry letters.

Evolution of preclinical characterization and insights into clinical pharmacology of checkpoint inhibitors approved for cancer immunotherapy

S. Mandlekar, S. Girish, S. Kasichayanula, 2022, Clinical and translational science.

Discovery of 5-Phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine as a Potent I Kur Inhibitor.

S. Mandlekar, Abhisek Banerjee, M. Conder, 2016, ACS medicinal chemistry letters.

BMS-813160: A Potent CCR2 and CCR5 Dual Antagonist Selected as a Clinical Candidate.

J. Barrish, S. Mandlekar, A. Mathur, 2021, ACS medicinal chemistry letters.

Improving Drug Delivery While Tailoring Prodrug Activation to Modulate Cmax and Cmin by Optimization of (Carbonyl)oxyalkyl Linker-Based Prodrugs of Atazanavir.

S. Mandlekar, N. Meanwell, M. Krystal, 2022, Journal of medicinal chemistry.

Tumor Necrosis Factor-related Apoptosis-inducing Ligand-mediated Apoptosis in Androgen-independent Prostate Cancer Cells 1

R. Yu, S. Mandlekar, A. Kong, 2000 .

Selective Inhibition of Eosinophil Influx into the Lung by Small Molecule CCR3 Antagonists in Mouse Models of Allergic Inflammation

K. McIntyre, S. Mandlekar, J. Trzăskos, 2006 .

Discovery and lead optimization of a novel series of CC chemokine receptor 1 (CCR1)-selective piperidine antagonists via parallel synthesis.

J. Chen, S. Mandlekar, C. Cavallaro, 2012, Journal of medicinal chemistry.

A CCR2/CCR5-dual antagonist, BMS-A, offers a potential novel oral therapy for the treatment of autoimmune disease (92.6)

K. McIntyre, J. Barrish, S. Mandlekar, 2009, Journal of Immunology.

Modulation of metabolic enzymes by dietary phytochemicals: a review of mechanisms underlying beneficial versus unfavorable effects.

S. Mandlekar, A. Kong, Jin-Liern Hong, 2006, Current drug metabolism.

gamma-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.

Michael G. Yang, J. Barrish, S. Mandlekar, 2010, Bioorganic & medicinal chemistry letters.

Prodrug design to improve pharmacokinetic and drug delivery properties: challenges to the discovery scientists.

S. Mandlekar, S. Jana, P. Marathe, 2010, Current medicinal chemistry.

Design, Synthesis, and Evaluation of Benzothiadiazepine Hydroxamates as Selective Tumor Necrosis Factor-α Converting Enzyme Inhibitors

S. Mandlekar, K. D. Hardman, R. Magolda, 2003 .

Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5.

D. J. Nelson, J. Barrish, S. Mandlekar, 2015, ACS medicinal chemistry letters.

Activation of p38 and c-Jun N-terminal Kinase Pathways and Induction of Apoptosis by Chelerythrine Do Not Require Inhibition of Protein Kinase C*

R. Yu, S. Mandlekar, A. Kong, 2000, The Journal of Biological Chemistry.

Role of phase II drug metabolizing enzymes in cancer chemoprevention.

Snehasis Jana, S. Mandlekar, S. Jana, 2009, Current drug metabolism.

Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors.

S. Mandlekar, K. D. Hardman, R. Magolda, 2003, Journal of medicinal chemistry.

Characterization of Recombinantly Expressed Rat and Monkey Intestinal Alkaline Phosphatases: In Vitro Studies and In Vivo Correlations

S. Mandlekar, S. Jana, P. Marathe, 2013, Drug Metabolism and Disposition.

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S. Mandlekar, S. Jana, P. Marathe, 2013 .

Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir.

S. Mandlekar, N. Meanwell, M. Krystal, 2019, Journal of medicinal chemistry.

Coupling of an Acyl Migration Prodrug Strategy with Bio-activation To Improve Oral Delivery of the HIV-1 Protease Inhibitor Atazanavir.

S. Mandlekar, N. Meanwell, M. Krystal, 2018, Journal of medicinal chemistry.

Induction of xenobiotic enzymes by the map kinase pathway and the antioxidant or electrophile response element (ARE/EpRE),†,‡

R. Yu, S. Mandlekar, A. Kong, 2001, Drug metabolism reviews.

From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis.

I. Kariv, S. Mandlekar, A. Tebben, 2008, Bioorganic & medicinal chemistry letters.

Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain

Alan G. E. Wilson, G. Shankar, S. Mandlekar, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Pharmacodynamics and Toxicodynamics of Drug Action: Signaling in Cell Survival and Cell Death

W. Lei, R. Yu, S. Mandlekar, 1999, Pharmaceutical Research.

Signal transduction events elicited by cancer prevention compounds.

R. Yu, S. Mandlekar, A. Kong, 2001, Mutation research.

Signal transduction events elicited by natural products: Role of MAPK and caspase pathways in homeostatic response and induction of apoptosis

R. Yu, S. Mandlekar, A. Kong, 2000, Archives of pharmacal research.

Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells

R. Yu, S. Mandlekar, A. Kong, 1999, Oncogene.

Mechanisms of tamoxifen-induced apoptosis

S. Mandlekar, A. Kong, 2001, Apoptosis.

Role of a Mitogen-activated Protein Kinase Pathway in the Induction of Phase II Detoxifying Enzymes by Chemicals*

Jie Wu, C. Der, R. Yu, 1999, The Journal of Biological Chemistry.

Molecular mechanisms of butylated hydroxylanisole-induced toxicity: induction of apoptosis through direct release of cytochrome c.

R. Yu, S. Mandlekar, A. Kong, 2000, Molecular pharmacology.

Electrophilicity of pyridazine-3-carbonitrile, pyrimidine-2-carbonitrile, and pyridine-carbonitrile derivatives: a chemical model to describe the formation of thiazoline derivatives in human liver microsomes.

S. Mandlekar, S. Sinha, K. Selvakumar, 2014, Chemical research in toxicology.

Spotting of external calibration standards on blank dried blood spots as a resource-sparing protocol.

S. Mandlekar, P. Kole, Murali Subramanian, 2017, Bioanalysis.

Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide.

S. Mandlekar, A. Mathur, Abhisek Banerjee, 2017, Journal of medicinal chemistry.

Prediction of pH dependent absorption using in vitro, in silico, and in vivo rat models: Early liability assessment during lead optimization.

S. Mandlekar, Ajay Saxena, S. Desikan, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Pharmacodynamics of tamoxifen and its 4-hydroxy and N-desmethyl metabolites: activation of caspases and induction of apoptosis in rat mammary tumors and in human breast cancer cell lines.

S. Mandlekar, A. Kong, V. Hebbar, 2000, Cancer research.

Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672.

Michael G. Yang, Michael A. Galella, J. Barrish, 2019, ACS medicinal chemistry letters.

Role of hepatic blood flow and metabolism in the pharmacokinetics of ten drugs in lean, aged and obese rats

S. Mandlekar, P. Marathe, R. Vikramadithyan, 2014, Xenobiotica; the fate of foreign compounds in biological systems.

Single jugular vein cannulated rats may not be suitable for intravenous pharmacokinetic screening of high logP compounds

M. Matta, S. Mandlekar, Anoop Kumar, 2017, European Journal of Pharmaceutical Sciences.

Absolute quantification of imipramine and its metabolites in vivo utilizing calibrators from radiolabeled in vitro incubations.

S. Mandlekar, Ninad Varkhede, Priyadeep Bhutani, 2016, Bioanalysis.

A simplified protocol employing elacridar in rodents: a screening model in drug discovery to assess P-gp mediated efflux at the blood brain barrier.

S. Mandlekar, R. Kallem, S. Singh, 2012, Drug Metabolism Letters.

Inhibition of AAK 1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain s

Alan G. E. Wilson, Malley, G. Shankar, 2016 .

Abstract CT029: Phase Ib study of GDC-6036 in combination with cetuximab in patients with colorectal cancer (CRC) with KRAS G12C mutation

J. Desai, S. Mandlekar, W. Miller, 2023, Cancer Research.

A Novel Liquid Chromatography Tandem Mass Spectrometry Method for the Estimation of Bilirubin Glucuronides and its Application to In Vitro Enzyme Assays.

M. Matta, S. Mandlekar, S. P. Putluru, 2017, Drug metabolism letters.

Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation.

S. Mandlekar, L. Paz-Ares, Yoonha Choi, 2023, The New England journal of medicine.

Metabolite Identification, Reaction Phenotyping, and Retrospective Drug-Drug Interaction Predictions of 17-Deacetylnorgestimate, the Active Component of the Oral Contraceptive Norgestimate

S. Mandlekar, S. Sinha, R. Iyer, 2017, Drug Metabolism and Disposition.