H. Rosing

发表

Electrospray ionization quadrupole ion-mobility time-of-flight mass spectrometry as a tool to distinguish the lot-to-lot heterogeneity in N-glycosylation profile of the therapeutic monoclonal antibody trastuzumab

C. Damen, Weibin Chen, A. Chakraborty, 2009, Journal of the American Society for Mass Spectrometry.

An excretion balance and pharmacokinetic study of the novel anticancer agent E7070 in cancer patients

J. Schellens, H. Rosing, J. Beijnen, 2002, Anti-cancer drugs.

Quantitative determination of capecitabine and its six metabolites in human plasma using liquid chromatography coupled to electrospray tandem mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a 14C-microtracer and therapeutic dose in cancer patients

J. Schellens, H. Rosing, J. Beijnen, 2017, Cancer Chemotherapy and Pharmacology.

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria

H. Rosing, J. Beijnen, F. Kuipers, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Multidrug Transporter ABCG2/Breast Cancer Resistance Protein Secretes Riboflavin (Vitamin B2) into Milk

H. Rosing, J. Beijnen, A. V. van Herwaarden, 2006, Molecular and Cellular Biology.

The Effect of St John’s Wort on the Pharmacokinetics of Docetaxel

J. Schellens, H. Rosing, J. Beijnen, 2013, Clinical Pharmacokinetics.

Bioequivalence of Liposome-Entrapped Paclitaxel Easy-To-Use (LEP-ETU) formulation and paclitaxel in polyethoxylated castor oil: a randomized, two-period crossover study in patients with advanced cancer.

H. Rosing, J. Beijnen, H. Guchelaar, 2013, Clinical therapeutics.

DPYD genotype-guided dose individualization of fluoropyrimidine therapy: A prospective safety and cost-analysis on DPYD variants DPYD*2A, c.2846A>T, c.1679T>G and c.1236G>A.

A. V. van Kuilenburg, H. Rosing, J. Beijnen, 2018, Annals of oncology : official journal of the European Society for Medical Oncology.

Stable isotopically labeled internal standards in quantitative bioanalysis using liquid chromatography/mass spectrometry: necessity or not?

H. Rosing, J. Beijnen, E. Stokvis, 2005, Rapid communications in mass spectrometry : RCM.

DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis.

A. V. van Kuilenburg, J. Schellens, H. Rosing, 2018, The Lancet. Oncology.

Procedures and practices for the validation of bioanalytical methods using dried blood spots: a review.

J. Schellens, H. Rosing, J. Beijnen, 2014, Bioanalysis.

Abstract OT2-01-11: Phase II of POSEIDON: A phase Ib / randomized phase II trial of tamoxifen plus taselisib or placebo in hormone receptor positive, HER2 negative, metastatic breast cancer patients with prior exposure to endocrine treatment

R. Bernards, C. Caldas, Mariette Schrier, 2017 .

Limited sampling models for topotecan pharmacokinetics.

J. Verweij, H. Rosing, J. Beijnen, 1994, Annals of oncology : official journal of the European Society for Medical Oncology.

P‐glycoprotein (MDR1/ABCB1) controls brain accumulation and intestinal disposition of the novel TGF‐β signaling pathway inhibitor galunisertib

H. Rosing, J. Beijnen, M. Tibben, 2020, International journal of cancer.

A phase I and pharmacokinetic study of ecteinascidin-743 on a daily x 5 schedule in patients with solid malignancies.

M. Hidalgo, G. Weiss, H. Rosing, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

Clinical pharmacology of the novel marine-derived anticancer agent Ecteinascidin 743 administered as a 1- and 3-h infusion in a phase I study

J. Schellens, H. Rosing, J. Beijnen, 2002, Anti-cancer drugs.

Analysis of Ecteinascidin 743, a new potent marine-derived anticancer drug, in human plasma by high-performance liquid chromatography in combination with solid-phase extraction.

H. Rosing, J. Beijnen, M. Hillebrand, 1998, Journal of chromatography. B, Biomedical sciences and applications.

Quantitative determination of Ecteinascidin 743 in human plasma by miniaturized high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

H. Rosing, J. Beijnen, M. Hillebrand, 1998, Journal of mass spectrometry : JMS.

Comparative open, randomized, cross-over bioequivalence study of two intravenous dexrazoxane formulations (Cardioxane® and ICRF-187) in patients with advanced breast cancer, treated with 5-fluorouracil-doxorubicin-cyclophosphamide (FDC)

H. Rosing, W. W. ten Bokkel Huinink, A. Bult, 2010, European Journal of Drug Metabolism and Pharmacokinetics.

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.

Ji-Ying Song, Jos H Beijnen, H. Rosing, 2007, The Journal of clinical investigation.

Pharmacokinetics of paclitaxel and carboplatin in a dose-escalating and dose-sequencing study in patients with non-small-cell lung cancer. The European Cancer Centre.

G. Giaccone, O. Dalesio, P. Postmus, 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Development and validation of LC-MS/MS assays for the quantification of E7080 and metabolites in various human biological matrices.

A. C. Dubbelman, J. Schellens, H. Rosing, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Oral Administration of Gemcitabine in Patients with Refractory Tumors: A Clinical and Pharmacologic Study

J. Schellens, H. Rosing, J. Beijnen, 2008, Clinical Cancer Research.

Population pharmacokinetic and adverse event analysis of topotecan in patients with solid tumors

D. Mould, J. Schellens, H. Rosing, 2002, Clinical pharmacology and therapeutics.

The co-solvent Cremophor EL limits absorption of orally administered paclitaxel in cancer patients

J. Schellens, H. Rosing, J. Beijnen, 2001, British Journal of Cancer.

Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein.

J. Schellens, H. Rosing, J. Beijnen, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Oral bioavailability of docetaxel in combination with OC144-093 (ONT-093)

J. Schellens, H. Rosing, J. Beijnen, 2004, Cancer Chemotherapy and Pharmacology.

Review on the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and its phase I and phase II metabolites in biological matrices, foodstuff and beverages.

J. Schellens, H. Rosing, J. Beijnen, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Validation of a liquid chromatographic method for the pharmaceutical quality control of products containing elacridar☆

J. Schellens, H. Rosing, J. Beijnen, 2016, Journal of pharmaceutical analysis.

Quantification of taxanes in biological matrices: a review of bioanalytical assays and recommendations for development of new assays.

J. Schellens, H. Rosing, J. Beijnen, 2014, Bioanalysis.

Safety and pharmacology of paclitaxel in patients with impaired liver function: a population pharmacokinetic-pharmacodynamic study.

J. Schellens, H. Rosing, J. Beijnen, 2007, British journal of clinical pharmacology.

Development and validation of a method to determine the unbound paclitaxel fraction in human plasma.

J. Schellens, H. Rosing, J. Beijnen, 2004, Analytical biochemistry.

High-performance liquid chromatographic analysis of the antitumour drug camptothecin and its lactone ring-opened form in rat plasma.

H. Rosing, J. Beijnen, W. W. ten Bokkel Huinink, 1993, Journal of chromatography.

The Pharmacokinetics of Topotecan and Its Carboxylate Form Following Separate Intravenous Administration to the Dog

H. Rosing, J. Beijnen, B. Davies, 1997, Pharmaceutical Research.

The bioanalysis of trastuzumab in human serum using precipitate-enhanced ellipsometry.

C. Damen, J. Schellens, H. Rosing, 2009, Analytical biochemistry.

Development and Validation of Limited-Sampling Models for the Antiretroviral Agent Zidovudine

H. Rosing, J. Beijnen, A. Bult, 1993 .

Toxicological analysis of azide and cyanide for azide intoxications using gas chromatography

D. D. de Lange, H. Rosing, J. Beijnen, 2020, Basic & clinical pharmacology & toxicology.

Results of a clinical pharmacokinetic (PK) bioequivalence (BE) study of liposomal paclitaxel (LEP-ETU) versus paclitaxel (T) in patients with advanced cancer.

H. Rosing, A. Tan, H. Gelderblom, 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

O-glucuronidation, a newly identified metabolic pathway for topotecan and N-desmethyl topotecan.

H. Rosing, J. Beijnen, A. Bult, 1998, Anti-cancer drugs.

Bottom-up sample preparation for the LC-MS/MS quantification of anti-cancer monoclonal antibodies in bio matrices.

H. Rosing, J. Beijnen, A. Huitema, 2020, Bioanalysis.

A real or apparent decrease in glomerular filtration rate in patients using olaparib?

S. Linn, H. Rosing, J. Beijnen, 2020, European Journal of Clinical Pharmacology.

Combining Isotopic Tracer Techniques to Increase Efficiency of Clinical Pharmacokinetic Trials in Oncology

H. Rosing, J. Beijnen, J. Roosendaal, 2020, Drugs in R&D.

Stable Isotopically Labeled Intravenous Microdose Pharmacokinetic Trials as a Tool to Assess Absolute Bioavailability: Feasibility and Paradigm to Apply for Protein Kinase Inhibitors in Oncology

H. Rosing, J. Beijnen, J. Roosendaal, 2020, Clinical pharmacology in drug development.

Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2′,2′‐difluorodeoxyuridine and their nucleotides

J. Schellens, H. Rosing, J. Beijnen, 2018, British journal of clinical pharmacology.

Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment.

J. Schellens, H. Rosing, J. Beijnen, 2016, British journal of clinical pharmacology.

Quantification of miltefosine in peripheral blood mononuclear cells by high-performance liquid chromatography-tandem mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in peripheral blood mononuclear cell lysate using liquid chromatography coupled with tandem mass spectrometry.

H. Rosing, J. Beijnen, R. ter Heine, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Randomized trial of cervene, a κ receptor-selective opioid antagonist, in acute ischemic stroke*

H. Rosing, R. Kelley, E. Raps, 1996 .

Metabolism of trabectedin (ET-743, Yondelis™) in patients with advanced cancer

J. Schellens, H. Rosing, J. Beijnen, 2007, Cancer Chemotherapy and Pharmacology.

A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin

H. Rosing, J. Beijnen, J. Lieverst, 2002, British Journal of Cancer.

P‐glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel

J. Schellens, H. Rosing, J. Beijnen, 2013, International journal of cancer.

Identification of drug metabolites in human plasma or serum integrating metabolite prediction, LC-HRMS and untargeted data processing.

H. Rosing, J. Beijnen, P. L. Jacobs, 2013, Bioanalysis.

Determination of the absolute bioavailability of oral imatinib using a stable isotopically labeled intravenous imatinib-d8 microdose

H. Rosing, J. Beijnen, A. Huitema, 2020, European Journal of Clinical Pharmacology.

Correction to: Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a 14C-microtracer and therapeutic dose in cancer patients

J. Schellens, H. Rosing, J. Beijnen, 2017, Cancer Chemotherapy and Pharmacology.

POSEIDON Trial Phase 1b Results: Safety, Efficacy and Circulating Tumor DNA Response of the Beta Isoform-Sparing PI3K Inhibitor Taselisib (GDC-0032) Combined with Tamoxifen in Hormone Receptor Positive Metastatic Breast Cancer Patients

R. Bernards, C. Caldas, Mariette Schrier, 2019, Clinical Cancer Research.

Stability of oxaliplatin in chloride-containing carrier solutions used in hyperthermic intraperitoneal chemotherapy.

H. Rosing, J. Beijnen, M. Hillebrand, 2015, International journal of pharmaceutics.

High-Performance Liquid Chromatographic Analysis of the Anticancer Drug Irinotecan (CPT-11) and Its Active Metabolite SN-38 in Human Plasma

J. Schellens, H. Rosing, J. Beijnen, 2003, Therapeutic drug monitoring.

Clinical phase II study and pharmacological evaluation of rubitecan in non-pretreated patients with metastatic colorectal cancer-significant effect of food intake on the bioavailability of the oral camptothecin analogue.

A. Ganser, J. Wanders, H. Rosing, 2002, European journal of cancer.

A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy.

A. V. van Kuilenburg, J. Schellens, H. Rosing, 2019, European journal of cancer.

Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel.

D. Richel, J. Schellens, H. Rosing, 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor.

J. Verweij, H. Rosing, J. Beijnen, 1996, British Journal of Cancer.

Impact of ABC transporters on the disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine) and its mutagenic metabolites in vivo

H. Rosing, J. Beijnen, A. Schinkel, 2009 .

Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity.

H. Rosing, J. Beijnen, A. V. van Herwaarden, 2009, Cancer research.

Quantification of anti-SARS-CoV-2 antibodies in human serum with LC-QTOF-MS

H. Rosing, J. Beijnen, A. Huitema, 2021, Journal of Pharmaceutical and Biomedical Analysis.

Dihydropyrimidine Dehydrogenase Phenotyping Using Pretreatment Uracil: A Note of Caution Based on a Large Prospective Clinical Study

A. V. van Kuilenburg, J. Maring, J. Schellens, 2022, Clinical pharmacology and therapeutics.

P-Glycoprotein (ABCB1) Transports the Primary Active Tamoxifen Metabolites Endoxifen and 4-Hydroxytamoxifen and Restricts Their Brain Penetration

H. Rosing, J. Beijnen, A. Schinkel, 2011, Journal of Pharmacology and Experimental Therapeutics.

Phase I and pharmacokinetics study of topotecan, a new topoisomerase I inhibitor.

H. Hansen, J. Verweij, H. Rosing, 1993, Annals of oncology : official journal of the European Society for Medical Oncology.

Exposure–response analyses of abiraterone and its metabolites in real-world patients with metastatic castration-resistant prostate cancer

H. Rosing, J. Beijnen, A. Huitema, 2019, Prostate Cancer and Prostatic Diseases.

A Phase I Dose Escalation Study of Once-Weekly Oral Administration of Docetaxel as ModraDoc001 Capsule or ModraDoc006 Tablet in Combination with Ritonavir

J. Schellens, H. Rosing, J. Beijnen, 2019, Clinical Cancer Research.

Exposure‐Response Assessment of Enzalutamide and Its Major Metabolites in a Real‐World Cohort of Patients with Metastatic Castration‐Resistant Prostate Cancer

H. Rosing, J. Beijnen, A. Bergman, 2019, Pharmacotherapy.

A dose-escalation study of bi-daily once weekly oral docetaxel either as ModraDoc001 or ModraDoc006 combined with ritonavir.

J. Schellens, H. Rosing, J. Beijnen, 2017, European journal of cancer.

Dose-finding and pharmacokinetic study of orally administered indibulin (D-24851) to patients with advanced solid tumors

J. Schellens, H. Rosing, J. Beijnen, 2010, Investigational New Drugs.

Phase I and pharmacokinetic study of the combination of topotecan and ifosfamide administered intravenously every 3 weeks

H. Rosing, J. Beijnen, G. Groenewegen, 2004, British Journal of Cancer.

Kinetic modeling and efficacy of intraperitoneal paclitaxel combined with intravenous cyclophosphamide and carboplatin as first-line treatment in ovarian cancer.

E. D. de Vries, H. Rosing, J. Beijnen, 2002, Gynecologic oncology.

Coadministration o f C yclosporine S trongly E nhances t he Oral B ioavailability o f D ocetaxel

D. Richel, H. Rosing, J. Beijnen, 2001 .

Pharmacokinetics of paclitaxel administered as a 3-hour or 96-hour infusion.

J. Schellens, H. Rosing, J. Beijnen, 1999, Pharmacological research.

Heterogeneous drug penetrance of veliparib and carboplatin measured in triple negative breast tumors

L. Esserman, D. Yee, B. Hann, 2017, Breast Cancer Research.

Treatment with the HIV protease inhibitor nelfinavir triggers the unfolded protein response and may overcome proteasome inhibitor resistance of multiple myeloma in combination with bortezomib: a phase I trial (SAKK 65/08)

H. Rosing, C. Berset, H. Hawle, 2016, Haematologica.

Phase I and pharmacokinetic study of ecteinascidin-743, a new marine compound, administered as a 24-hour continuous infusion in patients with solid tumors.

H. Rosing, E. Brain, J. Misset, 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Breast cancer resistance protein (Bcrp1/Abcg2) is expressed in the harderian gland and mediates transport of conjugated protoporphyrin IX.

H. Rosing, J. Beijnen, M. Hillebrand, 2007, American journal of physiology. Cell physiology.

Bioanalytical LC-MS/MS validation of therapeutic drug monitoring assays in oncology.

J. Schellens, H. Rosing, J. Beijnen, 2019, Biomedical chromatography : BMC.

Phase 1 Study of Combination Treatment with PTK 787/ZK 222584 and Cetuximab for Patients with Advanced Solid Tumors: Safety, Pharmacokinetics, Pharmacodynamics Analysis 1

H. Rosing, J. Beijnen, E. Voest, 2010 .

Metabolite profiling of 14C-omacetaxine mepesuccinate in plasma and excreta of cancer patients

J. Schellens, H. Rosing, E. Hellriegel, 2016, Xenobiotica; the fate of foreign compounds in biological systems.

A phase I study of intraperitoneal topotecan in combination with intravenous carboplatin and paclitaxel in advanced ovarian cancer.

E. D. de Vries, H. Rosing, J. Beijnen, 2005, European journal of cancer.

HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHODS FOR THE DETERMINATION OF A NOVEL POLYMER-BOUND PACLITAXEL DERIVATIVE AND FREE PACLITAXEL IN HUMAN PLASMA

J. Schellens, H. Rosing, J. Beijnen, 2000 .

Phase I and pharmacologic study of the combination of paclitaxel, cisplatin, and topotecan administered intravenously every 21 days as first-line therapy in patients with advanced ovarian cancer.

D. Richel, J. Schellens, H. Rosing, 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Bioanalytical methods for determination of tamoxifen and its phase I metabolites: a review.

J. Schellens, H. Rosing, J. Beijnen, 2010, Analytica chimica acta.

Concomitant intake of abiraterone acetate and food to increase pharmacokinetic exposure: real life data from a therapeutic drug monitoring programme.

H. Rosing, J. Beijnen, A. Bergman, 2020, European journal of cancer.

Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel

H. Rosing, J. Beijnen, E. van de Steeg, 2015, International journal of cancer.

Mass spectrometry in the quantitative analysis of therapeutic intracellular nucleotide analogs.

J. Schellens, H. Rosing, J. Beijnen, 2011, Mass spectrometry reviews.

Cost-Effectiveness Assessment of Monitoring Abiraterone Levels in Metastatic Castration-Resistant Prostate Cancer Patients.

H. Rosing, J. Beijnen, A. Huitema, 2020, Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research.

Co-administration of cyclosporin enables oral therapy with paclitaxel

J. Schellens, H. Rosing, J. Beijnen, 1998, The Lancet.

Quantitative analysis of the P-glycoprotein inhibitor Elacridar (GF120918) in human and dog plasma using liquid chromatography with tandem mass spectrometric detection.

J. Schellens, H. Rosing, J. Beijnen, 2004, Journal of mass spectrometry : JMS.

A rapid and simple HPLC-UV method for the determination of inhibition characteristics of farnesyl transferase inhibitors.

J. Schellens, H. Rosing, J. Beijnen, 2006, Biomedical chromatography : BMC.

Development and validation of a UPLC-MS/MS method with a broad linear dynamic range for the quantification of morphine, morphine-3-glucuronide and morphine-6-glucuronide in mouse plasma and tissue homogenates.

H. Rosing, J. Beijnen, M. Hillebrand, 2020, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Skin tissue sample collection, sample homogenization, and analyte extraction strategies for liquid chromatographic mass spectrometry quantification of pharmaceutical compounds.

H. Rosing, J. Beijnen, T. Dorlo, 2020, Journal of pharmaceutical and biomedical analysis.

A simple and sensitive assay for the quantitative analysis of rivastigmine and its metabolite NAP 226-90 in human EDTA plasma using coupled liquid chromatography and tandem mass spectrometry.

H. Rosing, J. Beijnen, L. Tulner, 2006, Rapid communications in mass spectrometry : RCM.

Chapter 3 Multidrug resistance protein 2 ( Mrp 2 ; Abcc 2 ) is an important determinant of paclitaxel pharmacokinetics

H. Rosing, J. Beijnen, A. Schinkel, 2009 .

Pharmacokinetics and pharmacodynamics of topotecan administered daily for 5 days every 3 weeks

J. Verweij, J. Schellens, H. Rosing, 1995, Cancer Chemotherapy and Pharmacology.

Capecitabine‐based treatment of a patient with a novel DPYD genotype and complete dihydropyrimidine dehydrogenase deficiency

A. V. van Kuilenburg, L. Zoetekouw, J. Schellens, 2018, International journal of cancer.

Do topotecan concentrations in saliva reflect plasma concentrations?

H. Rosing, W. W. ten Bokkel Huinink, L. V. van Warmerdam, 1995 .

The bioanalysis of the monoclonal antibody trastuzumab by high-performance liquid chromatography with fluorescence detection after immuno-affinity purification from human serum.

C. Damen, J. Schellens, H. Rosing, 2009, Journal of pharmaceutical and biomedical analysis.

Disposition and toxicity of trabectedin (ET-743) in wild-type and mdr1 gene (P-gp) knock-out mice

J. Schellens, H. Rosing, J. Beijnen, 2010, Investigational New Drugs.

P-glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain Disposition and Oral Availability of the Novel Taxane Cabazitaxel (Jevtana) in Mice.

H. Rosing, J. Beijnen, A. Schinkel, 2015, Molecular pharmaceutics.

Individual and combined roles of CYP3A, P‐glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel

H. Rosing, J. Beijnen, A. Schinkel, 2010, International journal of cancer.

ABCC2, ABCC3, and ABCB1, but not CYP3A, Protect against Trabectedin-Mediated Hepatotoxicity

H. Rosing, J. Beijnen, A. Schinkel, 2009, Clinical Cancer Research.

Chapter 2 Carcinogen and anti-cancer drug transport by Mrp 2 in vivo : studies using Mrp 2 ( Abcc 2 ) knockout mice

J. Schellens, H. Rosing, E. Wagenaar, 2009 .

Renal excretion of meta‐iodobenzylguanidine after therapeutic doses in cancer patients and its relation to dose and creatinine clearance

A. Wafelman, H. Rosing, B. Taal, 1995, Nuclear medicine communications.

No relation between docetaxel administration route and high‐grade diarrhea incidence

J. Schellens, H. Rosing, J. Beijnen, 2020, Pharmacology research & perspectives.

Food‐effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers

J. Schellens, H. Rosing, J. Beijnen, 2018, British journal of clinical pharmacology.

Method development and validation for the quantification of dasatinib, erlotinib, gefitinib, imatinib, lapatinib, nilotinib, sorafenib and sunitinib in human plasma by liquid chromatography coupled with tandem mass spectrometry.

J. Schellens, H. Rosing, M. Hillebrand, 2013, Biomedical chromatography : BMC.

Effect of Food on the Pharmacokinetics of the Oral Docetaxel Tablet Formulation ModraDoc006 Combined with Ritonavir (ModraDoc006/r) in Patients with Advanced Solid Tumours

H. Rosing, J. Beijnen, A. Huitema, 2021, Drugs in R&D.

Ritonavir inhibits intratumoral docetaxel metabolism and enhances docetaxel antitumor activity in an immunocompetent mouse breast cancer model

J. Schellens, H. Rosing, J. Beijnen, 2016, International journal of cancer.

Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation

J. Schellens, H. Rosing, J. Beijnen, 2014, British Journal of Cancer.

Coadministration of Ritonavir Strongly Enhances the Apparent Oral Bioavailability of Docetaxel in Patients with Solid Tumors

J. Schellens, H. Rosing, J. Beijnen, 2009, Clinical Cancer Research.

Development and validation of a LC-MS/MS method for the in vitro analysis of 1-hydroxymidazolam in human liver microsomes: application for determining CYP3A4 inhibition in complex matrix mixtures.

J. Schellens, H. Rosing, J. Beijnen, 2013, Biomedical chromatography : BMC.

Gemcitabine a nd P aclitaxel: P harmacokinetic and P harmacodynamic I nteractions i n P atients With N on-Small-Cell L ung C ancer

G. Peters, G. Giaccone, E. Smit, 1999 .

Gemcitabine and paclitaxel: pharmacokinetic and pharmacodynamic interactions in patients with non-small-cell lung cancer.

G. Peters, G. Giaccone, E. Smit, 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Development and validation of a liquid chromatography-tandem mass spectrometry assay for nine oral anticancer drugs in human plasma.

H. Rosing, J. Beijnen, A. Huitema, 2019, Journal of pharmaceutical and biomedical analysis.

Development and validation of a liquid chromatography-tandem mass spectrometry assay for the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and its metabolite 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) in plasma, urine, bile, intestinal contents, faeces an

J. Schellens, H. Rosing, J. Beijnen, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Human metabolism of [14C]indisulam following i.v. infusion in cancer patients

J. Schellens, H. Rosing, J. Beijnen, 2005, Investigational New Drugs.

Therapeutic drug monitoring based precision dosing of oral targeted therapies in oncology: a prospective multicentre study.

H. Rosing, H. Gelderblom, R. Mathijssen, 2022, Annals of oncology : official journal of the European Society for Medical Oncology.

Development and validation of a high-performance liquid chromatography tandem mass spectrometry method for the quantification of the antiparasitic and antifungal drug amphotericin B in human skin tissue.

H. Rosing, J. Beijnen, T. Dorlo, 2022, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Quantification of protease inhibitors and non-nucleoside reverse transcriptase inhibitors in dried blood spots by liquid chromatography-triple quadrupole mass spectrometry.

H. Rosing, J. Beijnen, A. Huitema, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Development and validation of an assay for the quantitative determination of cladribine nucleotides in MDCKII cells and culture medium using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.

H. Rosing, J. Beijnen, Cocky J F de Wolf, 2007, Rapid communications in mass spectrometry : RCM.

Quantitative analysis of gemcitabine triphosphate in human peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2006, Journal of mass spectrometry : JMS.

Retention studies of 2'-2'-difluorodeoxycytidine and 2'-2'-difluorodeoxyuridine nucleosides and nucleotides on porous graphitic carbon: development of a liquid chromatography-tandem mass spectrometry method.

J. Schellens, H. Rosing, J. Beijnen, 2009, Journal of chromatography. A.

Simultaneous quantification of 2',2'-difluorodeoxycytidine and 2',2'-difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2009, Rapid communications in mass spectrometry : RCM.

Dried Blood Spot Self-Sampling at Home for the Individualization of Tamoxifen Treatment: A Feasibility Study.

S. Linn, J. Schellens, H. Rosing, 2015, Therapeutic drug monitoring.

Development and validation of a quantitative assay for the determination of tamoxifen and its five main phase I metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Development and validation of a quantitative assay for the analysis of tamoxifen with its four main metabolites and the flavonoids daidzein, genistein and glycitein in human serum using liquid chromatography coupled with tandem mass spectrometry.

S. Linn, J. Schellens, H. Rosing, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Search for metabolites of ecteinascidin 743, a novel, marine-derived, anti-cancer agent, in man

J. Schellens, H. Rosing, J. Beijnen, 2001, Anti-cancer drugs.

Influence of Cremophor EL on the quantification of paclitaxel in plasma using high-performance liquid chromatography with solid-phase extraction as sample pretreatment.

H. Rosing, J. Beijnen, M. Huizing, 1998, Journal of chromatography. B, Biomedical sciences and applications.

Urinary and fecal excretion of topotecan in patients with malignant solid tumours

J. Schellens, H. Rosing, J. Beijnen, 2002, Cancer Chemotherapy and Pharmacology.

Quantification of topotecan and its metabolite N-desmethyltopotecan in human plasma, urine and faeces by high-performance liquid chromatographic methods.

J. Schellens, H. Rosing, J. Beijnen, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Bio-analysis of docetaxel and hydroxylated metabolites in human plasma by high-performance liquid chromatography and automated solid-phase extraction.

H. Rosing, J. Beijnen, W. W. ten Bokkel Huinink, 1997, Journal of chromatography. B, Biomedical sciences and applications.

A phase I and pharmacokinetic study of intraperitoneal topotecan

H. Rosing, J. Beijnen, P. Willemse, 2001, British Journal of Cancer.

Cost-Neutral Optimization of Pazopanib Exposure by Splitting Intake Moments: A Prospective Pharmacokinetic Study in Cancer Patients

H. Rosing, J. Beijnen, R. Mathijssen, 2020, Clinical Pharmacokinetics.

Fast and Straightforward Method for the Quantification of Pazopanib in Human Plasma Using LC-MS/MS

J. Schellens, H. Rosing, J. Beijnen, 2017, Therapeutic drug monitoring.

Development and clinical validation of an LC-MS/MS method for the quantification of pazopanib in DBS.

J. Schellens, H. Rosing, J. Beijnen, 2016, Bioanalysis.

Presence of Five Chemotherapeutic Drugs in Breast Milk as a Guide for the Safe Use of Chemotherapy During Breastfeeding: Results From a Case Series

H. Rosing, J. Beijnen, F. Amant, 2022, Clinical pharmacology and therapeutics.

Switching from an analogous to a stable isotopically labeled internal standard for the LC-MS/MS quantitation of the novel anticancer drug Kahalalide F significantly improves assay performance.

J. Schellens, H. Rosing, J. Beijnen, 2004, Biomedical chromatography : BMC.

1577PGERMLINE TYMS GENOTYPE IS HIGHLY PREDICTIVE IN PATIENTS WITH ADVANCED COLORECTAL AND GASTROESOPHAGEAL CANCER INDEPENDENT OF FLUOROPYRIMIDINE PHARMACOLOGY: RESULTS FROM TWO PROSPECTIVE TRANSLATIONAL STUDIES.

J. Schellens, H. Rosing, J. Beijnen, 2014, Annals of oncology : official journal of the European Society for Medical Oncology.

Safety and pharmacology of gemcitabine and capecitabine in patients with advanced pancreatico-biliary cancer and hepatic dysfunction

J. Schellens, H. Rosing, J. Beijnen, 2013, Cancer Chemotherapy and Pharmacology.

Quantitative analysis of ES-285, an investigational marine anticancer drug, in human, mouse, rat, and dog plasma using coupled liquid chromatography and tandem mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2003, Journal of mass spectrometry : JMS.

Quantitative analysis of the novel depsipeptide anticancer drug Kahalalide F in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray ionization tandem mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2002, Journal of mass spectrometry : JMS.

Intra-Tumoral Pharmacokinetics of Pazopanib in Combination with Radiotherapy in Patients with Non-Metastatic Soft-Tissue Sarcoma

H. Rosing, H. Gelderblom, R. Haas, 2021, Cancers.

Running title : Complete DPD deficiency caused by a novel DPYD genotype Article category : Cancer therapy and prevention Metadata : Word count : 2122

L. Zoetekouw, J. Schellens, H. Rosing, 2017 .

High-performance liquid chromatographic determination of the novel antitumour drug topotecan and topotecan as the total of the lactone plus carboxylate forms, in human plasma.

H. Rosing, J. Beijnen, B. Davies, 1995, Journal of chromatography. B, Biomedical applications.

Pharmacokinetic study of docetaxel in intraoperative hyperthermic i.p. chemotherapy for ovarian cancer

H. Rosing, J. Beijnen, D. Tsiftsis, 2003, Anti-cancer drugs.

Deoxyuridine analog nucleotides in deoxycytidine analog treatment: secondary active metabolites?

J. Schellens, H. Rosing, J. Beijnen, 2011, Fundamental & clinical pharmacology.

The bioanalysis of vinorelbine and 4-O-deacetylvinorelbine in human and mouse plasma using high-performance liquid chromatography coupled with heated electrospray ionization tandem mass-spectrometry.

C. Damen, J. Schellens, H. Rosing, 2009, Biomedical chromatography : BMC.

A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry.

C. Damen, J. Schellens, H. Rosing, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

HPLC determination of doxorubicin, doxorubicinol and four aglycone metabolites in plasma of AIDS patients.

H. Rosing, J. Beijnen, R. Gijn, 1991, Journal of pharmaceutical and biomedical analysis.

Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine.

J. Schellens, H. Rosing, J. Beijnen, 2019, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Gene polymorphisms, pharmacokinetics, and hematological toxicity in advanced non-small-cell lung cancer patients receiving cisplatin/gemcitabine

J. Schellens, H. Rosing, J. Beijnen, 2011, Cancer Chemotherapy and Pharmacology.

Novel paclitaxel formulations for oral application: a phase I pharmacokinetic study in patients with solid tumours

J. Schellens, H. Rosing, J. Beijnen, 2007, Cancer Chemotherapy and Pharmacology.

Effects of the Moderate CYP3A4 Inhibitor Erythromycin on the Pharmacokinetics of Palbociclib: A Randomized Crossover Trial in Patients With Breast Cancer

H. Rosing, J. Beijnen, R. Mathijssen, 2021, Clinical pharmacology and therapeutics.

Development and validation of a bioanalytical method for the quantification of the CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib in human and mouse matrices using liquid chromatography-tandem mass spectrometry

H. Rosing, J. Beijnen, M. Hillebrand, 2019, Analytical and Bioanalytical Chemistry.

Liquid chromatography-mass spectrometry for the quantitative bioanalysis of anticancer drugs.

H. Rosing, J. Beijnen, E. Stokvis, 2005, Mass spectrometry reviews.

Upfront Genotyping of DPYD*2A to Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis.

J. Schellens, H. Rosing, J. Beijnen, 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis

J. Schellens, H. Rosing, J. Beijnen, 2019, CPT: pharmacometrics & systems pharmacology.

Lysophospholipids secreted by splenic macrophages induce chemotherapy resistance via interference with the DNA damage response

Marijn T. M. van Jaarsveld, H. Rosing, J. Beijnen, 2014, Nature Communications.

Phase I and pharmacologic study of weekly doxorubicin and 1 h infusional paclitaxel in patients with advanced breast cancer.

J. Schellens, H. Rosing, J. Beijnen, 1998, Anti-cancer drugs.

Transtympanic Sodium Thiosulfate for Prevention of Cisplatin-Induced Ototoxicity: A Randomized Clinical Trial

W. Dreschler, M. Hauptmann, J. Schellens, 2021, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

Quantitative analysis of docetaxel in human plasma using liquid chromatography coupled with tandem mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2005, Biomedical chromatography : BMC.

PERFORMANCE OF THE ANALYTICAL ASSAYS OF PACLITAXEL, DOCETAXEL, AND CYCLOSPORIN A IN A ROUTINE HOSPITAL LABORATORY SETTING

J. Schellens, H. Rosing, J. Beijnen, 2001 .

Pharmacokinetics and metabolism of docetaxel administered as a 1-h intravenous infusion

S. Rodenhuis, J. Schellens, H. Rosing, 2000, Cancer Chemotherapy and Pharmacology.

Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism

I. Huijbers, H. Rosing, J. Beijnen, 2022, Acta pharmaceutica Sinica. B.

Limited Sampling Models for the Pharmacokinetics of Docetaxel

A. C. Dubbelman, H. Rosing, J. Beijnen, 1997 .

Combined quantification of paclitaxel, docetaxel and ritonavir in human feces and urine using LC-MS/MS.

J. Schellens, H. Rosing, J. Beijnen, 2014, Biomedical chromatography : BMC.

A sensitive combined assay for the quantification of paclitaxel, docetaxel and ritonavir in human plasma using liquid chromatography coupled with tandem mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A simple and sensitive assay for the quantitative analysis of paclitaxel and metabolites in human plasma using liquid chromatography/tandem mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2006, Biomedical chromatography : BMC.

A simple and sensitive assay for the quantitative analysis of paclitaxel in human and mouse plasma and brain tumor tissue using coupled liquid chromatography and tandem mass spectrometry.

H. Rosing, J. Beijnen, O. van Tellingen, 2004, Journal of mass spectrometry : JMS.

Pharmacokinetics of paclitaxel and three major metabolites in patients with advanced breast carcinoma refractory to anthracycline therapy treated with a 3-hour paclitaxel infusion: a European Cancer Centre (ECC) trial.

H. Rosing, J. Beijnen, W. W. ten Bokkel Huinink, 1995, Annals of oncology : official journal of the European Society for Medical Oncology.

Comparison of docetaxel pharmacokinetics between castration-resistant and hormone-sensitive metastatic prostate cancer patients

H. Rosing, J. Beijnen, A. Bergman, 2022, Cancer Chemotherapy and Pharmacology.

Volumetric absorptive microsampling (VAMS) as an alternative to conventional dried blood spots in the quantification of miltefosine in dried blood samples

J. Schellens, H. Rosing, J. Beijnen, 2017, Journal of pharmaceutical and biomedical analysis.

Pronounced between-subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers.

J. Schellens, H. Rosing, J. Beijnen, 2016, British journal of clinical pharmacology.

Sensitive Determination of the Carboxylate and Lactone Forms of the Novel Antitumor Drug Irinotecan and Its Active Metabolite in Plasma by HPLC

J. Schellens, H. Rosing, J. Beijnen, 1998 .

Simultaneous quantification of emtricitabine and tenofovir nucleotides in peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Mass balance and metabolite profiling of 14C-guadecitabine in patients with advanced cancer

H. Rosing, J. Beijnen, A. Huitema, 2019, Investigational New Drugs.

Pharmacokinetics and excretion of 14C–Plitidepsin in patients with advanced cancer

J. Schellens, H. Rosing, J. Beijnen, 2017, Investigational New Drugs.

Bioanalytical aspects of clinical mass balance studies in oncology.

A. C. Dubbelman, J. Schellens, H. Rosing, 2011, Bioanalysis.

A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma.

J. Schellens, H. Rosing, J. Beijnen, 2009, Biomedical chromatography : BMC.

Enhanced resolution triple-quadrupole mass spectrometry for ultra-sensitive and quantitative analysis of the investigational anticancer agent EO9 (apaziquone) and its metabolite EO5a in human and dog plasma to support (pre)-clinical studies of EOquin given intravesically.

J. Schellens, H. Rosing, J. Beijnen, 2008, Rapid communications in mass spectrometry : RCM.

Validated assay for the simultaneous determination of the anti-cancer agent gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma by high-performance liquid chromatography with tandem mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2007, Rapid communications in mass spectrometry : RCM.

Isolation and structural confirmation of N-desmethyl topotecan, a metabolite of topotecan

H. Rosing, J. Beijnen, V. Herben, 1997, Cancer Chemotherapy and Pharmacology.

The impact of column temperature in the high performance liquid chromatographic analysis of topotecan in rat and dog plasma.

H. Rosing, J. Beijnen, E. Doyle, 1996, Journal of pharmaceutical and biomedical analysis.

Tamoxifen dose and serum concentrations of tamoxifen and six of its metabolites in routine clinical outpatient care

S. Linn, J. Schellens, H. Rosing, 2014, Breast Cancer Research and Treatment.

Pharmacokinetics and pharmacodynamics of topotecan given on a daily-times-five schedule in phase II clinical trials using a limited-sampling procedure

S. Rodenhuis, J. Verweij, J. Schellens, 1996, Cancer Chemotherapy and Pharmacology.

Absolute quantification of farnesylated Ras levels in complex samples using liquid chromatography fractionation combined with tryptic digestion and electrospray tandem mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2006, Analytical biochemistry.

High-performance liquid chromatographic determination of m-iodobenzylguanidine in urine of cancer patients.

A. Wafelman, H. Rosing, R. Maes, 1993, Journal of chromatography.

Therapeutic drug monitoring of small molecule kinase inhibitors in oncology in a real‐world cohort study: does age matter?

J. Schellens, H. Rosing, J. Beijnen, 2018, British journal of clinical pharmacology.

Degradation of mitomycin C in acid phosphate and acetate buffer solutions

H. Rosing, J. Beijnen, R. Fokkens, 1986 .

Protein versus DNA as a marker for peripheral blood mononuclear cell counting

J. Schellens, H. Rosing, J. Beijnen, 2009, Analytical and bioanalytical chemistry.

Facile Small Scale Synthesis of Nucleoside 5′-Phosphate Mixtures

J. Schellens, H. Rosing, J. Beijnen, 2010, Nucleosides, nucleotides & nucleic acids.

The application of inductively coupled plasma mass spectrometry in clinical pharmacological oncology research.

J. Schellens, H. Rosing, J. Beijnen, 2008, Mass spectrometry reviews.

Pharmacokinetics and excretion of 14C-omacetaxine in patients with advanced solid tumors

J. Schellens, H. Rosing, J. Beijnen, 2016, Investigational New Drugs.

Development and validation of an UPLC-MS/MS method for the therapeutic drug monitoring of oral anti-hormonal drugs in oncology.

H. Rosing, J. Beijnen, N. Venekamp, 2019, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Highly sensitive UPLC-MS/MS method for the quantification of paromomycin in human plasma.

H. Rosing, J. Beijnen, J. Mbui, 2020, Journal of pharmaceutical and biomedical analysis.

High-performance liquid chromatographic determination of the antifungal drug fluconazole in plasma and saliva of human immunodeficiency virus-infected patients.

H. Rosing, J. Beijnen, A. Bult, 1995, Journal of chromatography. B, Biomedical applications.

BIOANALYTICAL LIQUID CHROMATOGRAPHIC METHOD VALIDATION. A REVIEW OF CURRENT PRACTICES AND PROCEDURES

Jos H. Beijnen, A. Bult, H. Rosing, 2000 .

The bioanalysis of the major Echinacea purpurea constituents dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides in human plasma using LC-MS/MS.

J. Schellens, H. Rosing, J. Beijnen, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A sensitive LC-MS/MS method for the quantitative analysis of the Echinacea purpurea constituent undeca-2-ene-8,10-diynoic acid isobutylamide in human plasma.

J. Schellens, H. Rosing, J. Beijnen, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Rapid quantification of HIV protease inhibitors in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

H. Rosing, L. Nan-Offeringa, M. Hillebrand, 2003, Journal of mass spectrometry : JMS.

Phenytoin alters the disposition of topotecan and N-desmethyl topotecan in a patient with medulloblastoma.

H. Rosing, J. Beijnen, P. Houghton, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Determination of 3'-amino-3'-deoxythymidine, a cytotoxic metabolite of 3'-azido-3'-deoxythymidine, in human plasma by ion-pair high-performance liquid chromatography.

H. Rosing, J. Beijnen, A. Bult, 1993, Journal of chromatography.

Determination of ruthenium originating from the investigational anti-cancer drug NAMI-A in human plasma ultrafiltrate, plasma, and urine by inductively coupled plasma mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2007, Rapid communications in mass spectrometry : RCM.

Determination of oxaliplatin in human plasma and plasma ultrafiltrate by graphite-furnace atomic-absorption spectrometry

J. Schellens, H. Rosing, J. Beijnen, 2005, Analytical and bioanalytical chemistry.

Determination of sunitinib and its active metabolite N-desethylsunitinib in sweat of a patient.

J. Schellens, H. Rosing, J. Beijnen, 2011, Journal of analytical toxicology.

Application of a radioimmunoassay for determination of levels of zalcitabine (ddC) in human plasma, urine, and cerebrospinal fluid

H. Rosing, J. Beijnen, J. Mulder, 1994, Antimicrobial Agents and Chemotherapy.

Determination of stavudine, a new antiretroviral agent, in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection.

H. Rosing, J. Beijnen, O. van Tellingen, 1992, Journal of chromatography.

Cytosine arabinoside and daunorubicin induction therapy in a patient with acute myeloid leukemia on chronic hemodialysis.

H. Rosing, M. Ellis, A. Huitema, 2016, Anti-cancer drugs.

Fast and simultaneous determination of darunavir and eleven other antiretroviral drugs for therapeutic drug monitoring: method development and validation for the determination of all currently approved HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in human plasma by liq

H. Rosing, J. Beijnen, A. Huitema, 2007, Rapid communications in mass spectrometry : RCM.

Development and validation of an assay for the simultaneous determination of zidovudine, abacavir, emtricitabine, lamivudine, tenofovir and ribavirin in human plasma using liquid chromatography-tandem mass spectrometry.

H. Rosing, J. Beijnen, J H Beijnen, 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Simple and rapid method for the simultaneous determination of the non-nucleoside reverse transcriptase inhibitors efavirenz and nevirapine in human plasma using liquid chromatography.

H. Rosing, J. Beijnen, A. Huitema, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.

J. Schellens, H. Rosing, J. Beijnen, 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Quantitative determination of oseltamivir and oseltamivir carboxylate in human fluoride EDTA plasma including the ex vivo stability using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

H. Rosing, J. Beijnen, A. Huitema, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses

J. Schellens, H. Rosing, J. Beijnen, 2015, Pharmacology research & perspectives.

Identification and Profiling of Circulating Metabolites of Atazanavir, a HIV Protease Inhibitor

H. Rosing, R. Heine, M. Hillebrand, 2009, Drug Metabolism and Disposition.

Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients.

A. C. Dubbelman, H. Rosing, J. Beijnen, 1993, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer

R. Bernards, J. Schellens, H. Rosing, 2020, British Journal of Cancer.

The quantitative analysis of heroin, methadone and their metabolites and the simultaneous detection of cocaine, acetylcodeine and their metabolites in human plasma by high-performance liquid chromatography coupled with tandem mass spectrometry.

Jos H Beijnen, E. J. Rook, H. Rosing, 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours.

J. Schellens, H. Rosing, J. Beijnen, 2002, European journal of cancer.

High-performance liquid chromatography coupled with mass spectrometry for the quantitative analysis of vinca-alkaloids in biological matrices: a concise survey from the literature.

C. Damen, J. Schellens, H. Rosing, 2010, Biomedical chromatography : BMC.

P-Glycoprotein (ABCB1/MDR1) Controls Brain Penetration and Intestinal Disposition of the PARP1/2 Inhibitor Niraparib.

H. Rosing, J. Beijnen, D. de Jong, 2021, Molecular pharmaceutics.

The role of drug efflux and uptake transporters ABCB1 (P-gp), ABCG2 (BCRP) and OATP1A/1B and of CYP3A4 in the pharmacokinetics of the CDK inhibitor milciclib.

H. Rosing, J. Beijnen, A. Schinkel, 2021, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Review of Chromatographic Bioanalytical Assays for the Quantitative Determination of Marine-Derived Drugs for Cancer Treatment

J. Schellens, H. Rosing, J. Beijnen, 2018, Marine drugs.

P-glycoprotein limits ribociclib brain exposure and CYP3A4 restricts its oral bioavailability.

H. Rosing, J. Beijnen, A. Schinkel, 2019, Molecular pharmaceutics.

Trabectedin (YondelisTM, formerly ET-743), a mass balance study in patients with advanced cancer

J. Schellens, H. Rosing, J. Beijnen, 2005, Investigational New Drugs.

Trabectedin (Yondelis, formerly ET-743), a mass balance study in patients with advanced cancer.

J. Schellens, H. Rosing, J. Beijnen, 2005, Investigational new drugs.

Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase I dose-finding study.

J. Schellens, H. Rosing, J. Beijnen, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Determination of the absolute bioavailability of oral imatinib using a stable isotopically labeled intravenous imatinib-d8 microdose

H. Rosing, J. Beijnen, A. Huitema, 2020, European Journal of Clinical Pharmacology.

Application of dried blood spots combined with high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry for simultaneous quantification of vincristine and actinomycin-D

C. Damen, J. Schellens, H. Rosing, 2009, Analytical and bioanalytical chemistry.

Interpretation of MS–MS spectra of small-molecule signal transduction inhibitors using accurate-m/z data and m/z-shifts with stable-isotope-labeled analogues and metabolites

H. Rosing, J. Beijnen, W. Niessen, 2021 .

Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity

J. Schellens, H. Rosing, J. Beijnen, 2017, British Journal of Cancer.

Human mass balance study and metabolite profiling of 14C-niraparib, a novel poly(ADP-Ribose) polymerase (PARP)-1 and PARP-2 inhibitor, in patients with advanced cancer

J. Schellens, H. Rosing, J. Beijnen, 2017, Investigational New Drugs.

Phase I study of lonafarnib (SCH66336) in combination with trastuzumab plus paclitaxel in Her2/neu overexpressing breast cancer: EORTC study 16023

J. Schellens, H. Rosing, J. Beijnen, 2013, Cancer Chemotherapy and Pharmacology.

Quantitative analysis of the farnesyl transferase inhibitor lonafarnib (Sarasartrade mark, SCH66336) in human plasma using high-performance liquid chromatography coupled with tandem mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2005, Rapid communications in mass spectrometry : RCM.

Validated assay for the simultaneous quantification of total vincristine and actinomycin-D concentrations in human EDTA plasma and of vincristine concentrations in human plasma ultrafiltrate by high-performance liquid chromatography coupled with tandem mass spectrometry.

C. Damen, J. Schellens, H. Rosing, 2009, Rapid communications in mass spectrometry : RCM.

Development and validation of an LC-MS/MS method for the quantitative analysis of milciclib in human and mouse plasma, mouse tissue homogenates and tissue culture medium.

H. Rosing, J. Beijnen, M. Tibben, 2020, Journal of pharmaceutical and biomedical analysis.

Optimized sample pre-treatment procedure for the simultaneous UPLC-MS/MS quantification of ipilimumab, nivolumab, and pembrolizumab in human serum.

H. Rosing, J. Beijnen, A. Huitema, 2022, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Development and validation of an enzyme-linked immunosorbent assay for the quantification of trastuzumab in human serum and plasma.

Jos H Beijnen, David S Boss, C. Damen, 2009, Analytical biochemistry.

Inductively coupled plasma mass spectrometric analysis of the total amount of platinum in DNA extracts from peripheral blood mononuclear cells and tissue from patients treated with cisplatin

J. Schellens, H. Rosing, J. Beijnen, 2008, Analytical and bioanalytical chemistry.

Brain Accumulation of Dasatinib Is Restricted by P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) and Can Be Enhanced by Elacridar Treatment

Jos H. Beijnen, Alfred H. Schinkel, H. Rosing, 2009, Clinical Cancer Research.

Metabolic Disposition of Lurbinectedin, a Potent Selective Inhibitor of Active Transcription of Protein-Coding Genes, in Nonclinical Species and Patients

J. Schellens, H. Rosing, J. Beijnen, 2022, Drug Metabolism and Disposition.

A sensitive liquid chromatographic-mass spectrometry method for the quantification of vincristine in whole blood collected with volumetric absorptive microsampling.

H. Rosing, J. Beijnen, A. Huitema, 2023, Journal of pharmaceutical and biomedical analysis.

A highly sensitive bioanalytical method for the quantification of vinblastine, vincristine, vinorelbine and 4-O-deacetylvinorelbine in human plasma using LC-MS/MS

H. Rosing, J. Beijnen, L. van Andel, 2022, Journal of Pharmaceutical and Biomedical Analysis.

Brain accumulation of sunitinib is restricted by P‐glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration

Jos H Beijnen, H. Rosing, J. Beijnen, 2012, International journal of cancer.

Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients

J. Schellens, H. Rosing, J. Beijnen, 2001, British Journal of Cancer.

Coadministration of oral cyclosporin A enables oral therapy with paclitaxel.

J. Schellens, H. Rosing, J. Beijnen, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

The effect of complementary and alternative medicines on CYP3A4‐mediated metabolism of three different substrates: 7‐benzyloxy‐4‐trifluoromethyl‐coumarin, midazolam and docetaxel

J. Schellens, H. Rosing, J. Beijnen, 2014, The Journal of pharmacy and pharmacology.

Exposure–response analyses of abiraterone and its metabolites in real-world patients with metastatic castration-resistant prostate cancer

H. Rosing, J. Beijnen, A. Huitema, 2019, Prostate Cancer and Prostatic Diseases.

Quantitative determination of erlotinib and O-desmethyl erlotinib in human EDTA plasma and lung tumor tissue.

J. Schellens, H. Rosing, J. Beijnen, 2012, Bioanalysis.

Phase II and pharmacologic study of weekly oral paclitaxel plus cyclosporine in patients with advanced non-small-cell lung cancer.

J. Schellens, H. Rosing, J. Beijnen, 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine.

J. Schellens, H. Rosing, J. Beijnen, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Quantification of Sunitinib and N-Desethyl Sunitinib in Human EDTA Plasma by Liquid Chromatography Coupled With Electrospray Ionization Tandem Mass Spectrometry: Validation and Application in Routine Therapeutic Drug Monitoring

J. Schellens, H. Rosing, J. Beijnen, 2013, Therapeutic drug monitoring.

Phase I and pharmacologic study of the combination paclitaxel and carboplatin as first-line chemotherapy in stage III and IV ovarian cancer.

S. Rodenhuis, H. Rosing, J. Beijnen, 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

A Phase 1 Dose‐Escalation Study of Low‐Dose Metronomic Treatment With Novel Oral Paclitaxel Formulations in Combination With Ritonavir in Patients With Advanced Solid Tumors

H. Rosing, J. Beijnen, A. Huitema, 2020, Clinical pharmacology in drug development.

Phase I pharmacological study of continuous chronomodulated capecitabine treatment

J. Schellens, H. Rosing, J. Beijnen, 2020, Pharmaceutical Research.

Vorinostat in patients with resistant BRAFV600E mutated advanced melanoma: a proof of concept study.

R. Bernards, J. Schellens, H. Rosing, 2020, Future oncology.

Simultaneous quantification of cyclophosphamide and its active metabolite 4-hydroxycyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-MS/MS).

S. Rodenhuis, H. Rosing, J. Beijnen, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Simultaneous quantification of cyclophosphamide, 4-hydroxycyclophosphamide, N,N',N"-triethylenethiophosphoramide (thiotepa) and N,N',N"-triethylenephosphoramide (tepa) in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

S. Rodenhuis, H. Rosing, J. Beijnen, 2004, Journal of mass spectrometry : JMS.

Liquid chromatography-tandem mass spectrometric assay for therapeutic drug monitoring of the B-Raf inhibitor encorafenib, the EGFR inhibitors afatinib, erlotinib and gefitinib and the O-desmethyl metabolites of erlotinib and gefitinib in human plasma.

J. Schellens, H. Rosing, J. Beijnen, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A simple extemporaneous oral suspension of aprepitant yields sufficient pharmacokinetic exposure in children.

W. Tissing, H. Rosing, C. Zwaan, 2022, Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.

Phase I study of lapatinib plus trametinib in patients with KRAS-mutant colorectal, non-small cell lung, and pancreatic cancer

R. Bernards, J. Schellens, H. Rosing, 2020, Cancer Chemotherapy and Pharmacology.

Development and validation of a combined liquid chromatography tandem-mass spectrometry assay for the quantification of aprepitant and dexamethasone in human plasma to support pharmacokinetic studies in pediatric patients.

H. Rosing, J. Beijnen, C. Zwaan, 2021, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Overestimation of the effect of (fos)aprepitant on intravenous dexamethasone pharmacokinetics requires adaptation of the guidelines for children with chemotherapy-induced nausea and vomiting

W. Tissing, H. Rosing, A. Huitema, 2022, Supportive Care in Cancer.

Efficacy, Tolerance, and Plasma Levels of Abiraterone and Its Main Metabolites in a Patient With Metastatic Castration-resistant Prostate Cancer With a Hepatic Transplant.

H. Rosing, J. Beijnen, B. van Hoek, 2019, Clinical genitourinary cancer.

Impact of age on exposure to oral antiandrogen therapies in clinical practice

J. Schellens, H. Rosing, J. Beijnen, 2018, Prostate Cancer and Prostatic Diseases.

ABCB1 and ABCG2 limit brain penetration and, together with CYP3A4, total plasma exposure of abemaciclib and its active metabolites.

H. Rosing, J. Beijnen, M. Tibben, 2021, Pharmacological research.

Carcinogen and Anticancer Drug Transport by Mrp2 in Vivo: Studies Using Mrp2 (Abcc2) Knockout Mice

J. Schellens, H. Rosing, J. Beijnen, 2006, Journal of Pharmacology and Experimental Therapeutics.

Simultaneous quantification of dabrafenib and trametinib in human plasma using high-performance liquid chromatography-tandem mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2016, Journal of pharmaceutical and biomedical analysis.

Determination of 9-nitrocamptothecin and its metabolite 9-aminocamptothecin in human plasma using high-performance liquid chromatography with ultraviolet and fluorescence detection.

J. Schellens, H. Rosing, J. Beijnen, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Bioanalytical method for the simultaneous quantification of irinotecan and its active metabolite SN-38 in mouse plasma and tissue homogenates using HPLC-fluorescence.

H. Rosing, J. Beijnen, A. Schinkel, 2020, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Pharmacokinetics and excretion of 14C-lenvatinib in patients with advanced solid tumors or lymphomas

A. C. Dubbelman, J. Schellens, H. Rosing, 2015, Investigational New Drugs.

Bayesian Pharmacokinetically Guided Dosing of Paclitaxel in Patients with Non-Small Cell Lung Cancer

J. Schellens, H. Rosing, J. Beijnen, 2004, Clinical Cancer Research.

High Performance Liquid Chromatographic Analysis of The Cardioprotective Agent Dexrazoxane in Human Plasma and Urine

H. Rosing, J. Beijnen, R. Gijn, 1997 .

Decitabine triphosphate levels in peripheral blood mononuclear cells from patients receiving prolonged low-dose decitabine administration: a pilot study

J. Schellens, H. Rosing, J. Beijnen, 2012, Cancer Chemotherapy and Pharmacology.

Intraductal cisplatin treatment in a BRCA-associated breast cancer mouse model attenuates tumor development but leads to systemic tumors in aged female mice

P. V. van Diest, H. Rosing, J. Beijnen, 2017, Oncotarget.

Development and validation of LC-MS/MS assays for the quantification of bendamustine and its metabolites in human plasma and urine.

A. C. Dubbelman, J. Schellens, H. Rosing, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Multidrug Resistance Protein 2 Is an Important Determinant of Paclitaxel Pharmacokinetics

H. Rosing, J. Beijnen, O. van Tellingen, 2006, Clinical Cancer Research.

Cytoreductive Surgery and Intraoperative Hyperthermic Intraperitoneal Chemotherapy with Paclitaxel: A Clinical and Pharmacokinetic Study

H. Rosing, J. Beijnen, E. Sanidas, 2008, Annals of Surgical Oncology.

Treatment of ovarian cancer using intraperitoneal chemotherapy with taxanes: from laboratory bench to bedside.

H. Rosing, J. Beijnen, D. Tsiftsis, 2006, Cancer treatment reviews.

Development of an optimal pharmacokinetic sampling schedule for rubitecan administered orally in a daily times five schedule

J. Schellens, H. Rosing, J. Beijnen, 2002, Cancer Chemotherapy and Pharmacology.

Stability of anthracycline antitumour agents in infusion fluids.

H. Rosing, J. Beijnen, P. de Vries, 1985, Journal of parenteral science and technology : a publication of the Parenteral Drug Association.

Phase I Pharmacokinetic and Pharmacodynamic Study of Carboplatin and Topotecan Administered Intravenously Every 28 Days to Patients with Malignant Solid Tumors

J. Schellens, H. Rosing, J. Beijnen, 2009, Clinical Cancer Research.

Oral topotecan: bioavailability and effect of food co-administration

J. Schellens, H. Rosing, J. Beijnen, 1999, British Journal of Cancer.

Bioavailability andpharmacokinetics oforal topotecan: a new topoisomerase Iinhibitor

H. Rosing, J. Beijnen, M. Boer-Dennert, 1996 .

Predictive Value of Microdose Pharmacokinetics

Jos H. Beijnen, Alwin D. R. Huitema, H. Rosing, 2019, Clinical Pharmacokinetics.

Multidrug Transporter ABCG2/Breast Cancer Resistance Protein Secretes Riboﬂavin (Vitamin B 2 ) into Milk (cid:1)

H. Rosing, J. Beijnen, A. Schinkel, 2007 .

Validation and Clinical Evaluation of a Novel Method To Measure Miltefosine in Leishmaniasis Patients Using Dried Blood Spot Sample Collection

J. Schellens, H. Rosing, J. Beijnen, 2016, Antimicrobial Agents and Chemotherapy.

Development and validation of a quantitative assay for the measurement of miltefosine in human plasma by liquid chromatography-tandem mass spectrometry.

H. Rosing, J. Beijnen, P. D. de Vries, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Development and validation of an ultra-high performance liquid chromatography coupled to tandem mass spectrometry method for the quantification of the antileishmanial drug paromomycin in human skin tissue.

H. Rosing, J. Beijnen, T. Dorlo, 2022, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Urinary excretion of paclitaxel and metabolites in a large series study

H. Rosing, J. Beijnen, L. V. van Warmerdam, 1998 .

Pharmacokinetics of paclitaxel administered in combination with cisplatin, etoposide and bleomycin in patients with advanced solid tumours

J. Schellens, H. Rosing, J. Beijnen, 1999, Cancer Chemotherapy and Pharmacology.

Limited Sampling Strategies for Investigating Paclitaxel Pharmacokinetics in Patients Receiving 175 mg/m2 as a 3-Hour Infusion

H. Rosing, J. Beijnen, H. Pinedo, 1995 .

Pharmacokinetics and Excretion of 14C-Bendamustine in Patients with Relapsed or Refractory Malignancy

A. C. Dubbelman, J. Schellens, H. Rosing, 2013, Drugs in R&D.

Phase I clinical and pharmacokinetic study of topotecan administered by a 24-hour continuous infusion.

S. Rodenhuis, H. Rosing, J. Beijnen, 1995, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel

J. Schellens, H. Rosing, J. Beijnen, 2001, Anti-cancer drugs.

Metabolism and excretion of paclitaxel after oral administration in combination with cyclosporin A and after i.v. administration

J. Schellens, H. Rosing, J. Beijnen, 2000, Anti-cancer drugs.

A pharmacokinetic and safety study of a novel polymeric paclitaxel formulation for oral application

J. Schellens, H. Rosing, J. Beijnen, 2006, Cancer Chemotherapy and Pharmacology.

The effect of different doses of cyclosporin A on the systemic exposure of orally administered paclitaxel

J. Schellens, H. Rosing, J. Beijnen, 2001, Anti-cancer drugs.

Development and validation of an HPLC-MS/MS method for the quantification of the anti-leishmanial drug miltefosine in human skin tissue.

H. Rosing, J. Beijnen, T. Dorlo, 2021, Journal of pharmaceutical and biomedical analysis.

Metabolite Profiling of Bendamustine in Urine of Cancer Patients after Administration of [14C]Bendamustine

A. C. Dubbelman, J. Schellens, H. Rosing, 2012, Drug Metabolism and Disposition.

Phase I and pharmacological trial of lapatinib in combination with gemcitabine in patients with advanced breast cancer

W. M. Smit, J. Schellens, H. Rosing, 2015, Investigational New Drugs.

The Use of Dried Blood Spots for Pharmacokinetic Monitoring of Vemurafenib Treatment in Melanoma Patients

J. Schellens, H. Rosing, J. Beijnen, 2016, Journal of clinical pharmacology.

Sensitive inductively coupled plasma mass spectrometry assay for the determination of platinum originating from cisplatin, carboplatin, and oxaliplatin in human plasma ultrafiltrate.

J. Schellens, H. Rosing, J. Beijnen, 2006, Journal of mass spectrometry : JMS.

Importance of highly selective LC–MS/MS analysis for the accurate quantification of tamoxifen and its metabolites: focus on endoxifen and 4-hydroxytamoxifen

S. Linn, J. Schellens, H. Rosing, 2012, Breast Cancer Research and Treatment.

Development and validation of a high‐performance liquid chromatography‐tandem mass spectrometry assay for the quantification of Dexamphetamine in human plasma

J. Schellens, H. Rosing, J. Beijnen, 2018, Journal of pharmaceutical and biomedical analysis.

LC–MS/MS assay for the quantification of testosterone, dihydrotestosterone, androstenedione, cortisol and prednisone in plasma from castrated prostate cancer patients treated with abiraterone acetate or enzalutamide

H. Rosing, J. Beijnen, H. V. van Rossum, 2019, Journal of pharmaceutical and biomedical analysis.

Intraperitoneal chemotherapy with taxanes for ovarian cancer with peritoneal dissemination.

H. Rosing, J. Beijnen, D. Tsiftsis, 2006, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

Systemic exposure of oxaliplatin and docetaxel in gastric cancer patients with peritonitis carcinomatosis treated with intraperitoneal hyperthermic chemotherapy.

H. Rosing, J. V. van Sandick, J. Schellens, 2020, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

A systematic study on the chemical stability of mitomycin A and mitomycin B.

H. Rosing, J. Beijnen, W. Underberg, 1986, Chemical and pharmaceutical bulletin.

Plasma Levels of Enzalutamide and Its Main Metabolites in a Patient With Metastatic Castration‐resistant Prostate Cancer Undergoing Hemodialysis

H. Rosing, J. Beijnen, A. Huitema, 2019, Clinical genitourinary cancer.

Impact of age on exposure to oral antiandrogen therapies in clinical practice

J. Schellens, H. Rosing, J. Beijnen, 2018, Prostate Cancer and Prostatic Diseases.

The effect of Echinacea purpurea on the pharmacokinetics of docetaxel.

J. Schellens, H. Rosing, J. Beijnen, 2013, British journal of clinical pharmacology.

Pharmaceutical development of a parenteral lyophilized formulation of the investigational antitumor neuropeptide antagonist [ Arg 6 , D-Trp 7 , 9 , MePhe 8 ]-Substance P { 6-11 }

H. Rosing, J. Beijnen, H. Talsma, 1998 .

Development and validation of an integrated LC-MS/MS assay for therapeutic drug monitoring of five PARP-inhibitors.

H. Rosing, J. Beijnen, L. Lucas, 2019, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

evelopment and validation of a high-performance liquid hromatography – tandem mass spectrometry assay quantifying laparib in human plasma

J. Schellens, H. Rosing, J. Beijnen, 2013 .

Exposure–Response Analyses of Anaplastic Lymphoma Kinase Inhibitors Crizotinib and Alectinib in Non‐Small Cell Lung Cancer Patients

E. Smit, H. Rosing, J. Beijnen, 2020, Clinical pharmacology and therapeutics.

DEVELOPMENT OF AN HPLC METHOD WITH UV DETECTION FOR THE PHARMACEUTICAL QUALITY CONTROL OF THE NOVEL MARINE ANTICANCER AGENT KAHALALIDE F

H. Rosing, J. Beijnen, E. Stokvis, 2001 .

Analysis of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and Its Phase I and Phase II Metabolites in Mouse Urine Using LC–UV–MS–MS

J. Schellens, H. Rosing, J. Beijnen, 2011 .

Germline TYMS genotype is highly predictive in patients with metastatic gastrointestinal malignancies receiving capecitabine-based chemotherapy

H. Rosing, J. Schellens, M. Joerger, 2015, Cancer Chemotherapy and Pharmacology.

Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison

A. C. Dubbelman, J. Schellens, H. Rosing, 2016, Investigational New Drugs.

Determination of tamoxifen and endoxifen in dried blood spots using LC-MS/MS and the effect of coated DBS cards on recovery and matrix effects.

J. Schellens, H. Rosing, J. Beijnen, 2014, Bioanalysis.

Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques.

J. Schellens, H. Rosing, J. Beijnen, 2011, Journal of pharmaceutical and biomedical analysis.

Phase I Study of Afatinib and Selumetinib in Patients with KRAS-Mutated Colorectal, Non-Small Cell Lung, and Pancreatic Cancer.

R. Bernards, J. Schellens, H. Rosing, 2020, The oncologist.

Simple and sensitive liquid chromatographic quantitative analysis of the novel marine anticancer drug Yondelis (ET-743, trabectedin) in human plasma using column switching and tandem mass spectrometric detection.

H. Rosing, J. Beijnen, E. Stokvis, 2004, Journal of mass spectrometry : JMS.

Pharmacokinetics and Pharmacodynamics of the Novel Marine-derived Anticancer Agent Ecteinascidin 743 in a Phase I Dose-finding Study 1

J. Schellens, H. Rosing, J. Beijnen, 2000 .

Validation of high-performance liquid chromatography-tandem mass spectrometry assays quantifying omacetaxine mepesuccinate and its 4'‑des-methyl and cephalotaxine metabolites in human plasma and urine.

J. Schellens, H. Rosing, J. Beijnen, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Therapeutic drug monitoring of imatinib in patients with gastrointestinal stromal tumours - Results from daily clinical practice.

H. Rosing, J. Beijnen, A. Huitema, 2020, European journal of cancer.

Development and validation of a liquid chromatography-tandem mass spectrometry analytical method for the therapeutic drug monitoring of eight novel anticancer drugs.

J. Schellens, H. Rosing, J. Beijnen, 2018, Biomedical chromatography : BMC.

Development and Validation of an LC-MS/MS Method for the Simultaneous Quantification of Abiraterone, Enzalutamide, and Their Major Metabolites in Human Plasma

J. Schellens, H. Rosing, J. Beijnen, 2017, Therapeutic drug monitoring.

Fast and Adequate Liquid Chromatography–Tandem Mass Spectrometric Determination of Z-endoxifen Serum Levels for Therapeutic Drug Monitoring

J. Schellens, H. Rosing, J. Beijnen, 2017, Therapeutic drug monitoring.

Quantification of 11 Therapeutic Kinase Inhibitors in Human Plasma for Therapeutic Drug Monitoring Using Liquid Chromatography Coupled With Tandem Mass Spectrometry

J. Schellens, H. Rosing, J. Beijnen, 2016, Therapeutic drug monitoring.

Simultaneous Quantitative Analysis of EO9 (Apaziquone) and its Conversion Products EO5a and EO9-Cl in Human and Dog Urine by High-Performance Liquid Chromatography Coupled with Electrospray Tandem Mass Spectrometry

J. Schellens, H. Rosing, J. Beijnen, 2009 .

Stability experiments in human urine with EO9 (apaziquone): a novel anticancer agent for the intravesical treatment of bladder cancer.

J. Schellens, H. Rosing, J. Beijnen, 2007, Journal of pharmaceutical and biomedical analysis.

Quantitative analysis of EO9 (apaziquone) and its metabolite EO5a in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray tandem mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2006, Journal of mass spectrometry : JMS.

Phase I Study of Afatinib and Selumetinib in Patients with KRASâ•’Mutated Colorectal, Nonâ•’Small Cell Lung, and Pancreatic Cancer

R. Bernards, H. Rosing, J. Beijnen, 2021 .

Metabolite profiling of the novel anti-cancer agent, plitidepsin, in urine and faeces in cancer patients after administration of 14C-plitidepsin

J. Schellens, H. Rosing, J. Beijnen, 2018, Cancer Chemotherapy and Pharmacology.

Liquid chromatography‐tandem mass spectrometry assay to quantify plitidepsin in human plasma, whole blood and urine

J. Schellens, H. Rosing, J. Beijnen, 2017, Journal of pharmaceutical and biomedical analysis.

Development and validation of a rapid and sensitive UPLC-MS/MS method for determination of uracil and dihydrouracil in human plasma.

J. Schellens, H. Rosing, J. Beijnen, 2016, Journal of pharmaceutical and biomedical analysis.

Assay performance and stability of uracil and dihydrouracil in clinical practice

H. Rosing, J. Beijnen, A. Cats, 2023, Cancer Chemotherapy and Pharmacology.

The impact of liver resection on the dihydrouracil:uracil plasma ratio in patients with colorectal liver metastases

J. Schellens, H. Rosing, J. Beijnen, 2018, European Journal of Clinical Pharmacology.

Weekly oral paclitaxel as first-line treatment in patients with advanced gastric cancer.

H. Rosing, J. Beijnen, J. Schellens, 2003, Annals of oncology : official journal of the European Society for Medical Oncology.

Phase I and pharmacokinetic study of oral paclitaxel.

J. Schellens, H. Rosing, J. Beijnen, 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Quantification of paclitaxel metabolites in human plasma by high-performance liquid chromatography.

H. Rosing, J. Beijnen, A. Sparreboom, 1995, Journal of chromatography. B, Biomedical applications.

Development and validation of an LC-MS/MS method with a broad linear dynamic range for the quantification of tivozanib in human and mouse plasma, mouse tissue homogenates, and culture medium.

H. Rosing, J. Beijnen, A. Schinkel, 2019, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Brain accumulation of tivozanib is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein) in mice.

H. Rosing, J. Beijnen, A. Schinkel, 2020, International journal of pharmaceutics.

Validation and clinical application of an LC-MS/MS method for the quantification of everolimus using volumetric absorptive microsampling.

J. Schellens, H. Rosing, J. Beijnen, 2019, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Use of dried blood spots for the determination of plasma concentrations of nevirapine and efavirenz.

H. Rosing, J. Beijnen, A. Huitema, 2012, The Journal of antimicrobial chemotherapy.

Pilot Study to Predict Pharmacokinetics of a Therapeutic Gemcitabine Dose From a Microdose

J. Schellens, H. Rosing, S. Marchetti, 2020, Clinical pharmacology in drug development.

Ultra‐sensitive LC–MS/MS method for the quantification of gemcitabine and its metabolite 2′,2′‐difluorodeoxyuridine in human plasma for a microdose clinical trial

J. H. Beijnen, J. Schellens, H. Rosing, 2018, Journal of pharmaceutical and biomedical analysis.

A phase 0 clinical trial of novel candidate extended-release formulations of capecitabine

Jos H. Beijnen, J. Schellens, H. Rosing, 2016, Cancer Chemotherapy and Pharmacology.

Phase I study of afatinib plus selumetinib in patients with KRAS mutation-positive colorectal, non-small cell lung and pancreatic cancer.

R. Bernards, J. Schellens, H. Rosing, 2020 .

High-performance liquid chromatographic procedures for the quantitative determination of paclitaxel (Taxol) in human urine.

H. Rosing, J. Beijnen, H. Pinedo, 1995, Journal of chromatography. B, Biomedical applications.

Simultaneous quantification of the new HIV protease inhibitors atazanavir and tipranavir in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

H. Rosing, J. Beijnen, A. Huitema, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Quantification of the HIV-integrase inhibitor raltegravir and detection of its main metabolite in human plasma, dried blood spots and peripheral blood mononuclear cell lysate by means of high-performance liquid chromatography tandem mass spectrometry.

H. Rosing, M. Hillebrand, R. ter Heine, 2009, Journal of pharmaceutical and biomedical analysis.

Cost-effectiveness of monitoring endoxifen levels in breast cancer patients adjuvantly treated with tamoxifen

J. Schellens, H. Rosing, J. Beijnen, 2018, Breast Cancer Research and Treatment.

Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug metabolism and metabolic syndrome development.

H. Rosing, J. Beijnen, M. Altelaar, 2023, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

A review of the bioanalytical methods for the quantitative determination of capecitabine and its metabolites in biological matrices.

H. Rosing, J. Beijnen, H. Guchelaar, 2020, Biomedical chromatography : BMC.

Tandem mass spectrometry of small-molecule signal transduction inhibitors: Accurate-m/z data to adapt structure proposals of product ions.

H. Rosing, J. Beijnen, W. Niessen, 2020, Journal of Pharmaceutical and Biomedical Analysis.

Use of dried blood spots for the determination of serum concentrations of tamoxifen and endoxifen

S. Linn, J. Schellens, H. Rosing, 2014, Breast Cancer Research and Treatment.

Intraductal cisplatin treatment in a BRCA-associated breast cancer mouse model attenuates tumor development but leads to systemic tumors in aged female mice

P. V. van Diest, H. Rosing, J. Beijnen, 2017, Oncotarget.

Liquid chromatography-tandem mass spectrometric assay for the quantification of galunisertib in human plasma and the application in a pre-clinical study.

H. Rosing, J. Beijnen, M. Tibben, 2019, Journal of pharmaceutical and biomedical analysis.

924 Pharmacology of paclitaxel (P) and metabolites in patients with altered liver function

A. Graeff, H. Rosing, J. Beijnen, 1995 .

A Phase 1 Comparative Pharmacokinetic and Cardiac Safety Study of Two Intravenous Formulations of CO‐101 in Patients With Advanced Solid Tumors

J. Schellens, H. Rosing, J. Beijnen, 2013, Journal of clinical pharmacology.

A less sensitive detector does not necessarily result in a less sensitive method: fast quantification of 13 antiretroviral analytes in plasma with liquid chromatography coupled with tandem mass spectrometry

H. Rosing, J. Beijnen, A. Huitema, 2010, Clinical chemistry and laboratory medicine.

Quantification of etravirine (TMC125) in plasma, dried blood spots and peripheral blood mononuclear cell lysate by liquid chromatography tandem mass spectrometry.

H. Rosing, R. ter Heine, J. Beijnen, 2009, Journal of pharmaceutical and biomedical analysis.

Bcrp1;Mdr1a/b;Mrp2 Combination Knockout Mice: Altered Disposition of the Dietary Carcinogen PhIP (2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine) and Its Genotoxic Metabolites

Tom F. A. de Greef, Jos H. Beijnen, Luc Brunsveld, 2014, Molecular Pharmacology.

Quantitative analysis of D-24851, a novel anticancer agent, in human plasma and urine by liquid chromatography coupled with tandem mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2004, Rapid Communications in Mass Spectrometry.

Phase I pharmacological study of continuous chronomodulated capecitabine treatment

J. Schellens, H. Rosing, J. Beijnen, 2018, Pharmaceutical Research.

Stability of intravenous admixtures of doxorubicin and vincristine.

H. Rosing, J. Beijnen, O. Meuwissen, 1986, American journal of hospital pharmacy.

Quantitative aspects of the analysis of the monoclonal antibody trastuzumab using high-performance liquid chromatography coupled with electrospray mass spectrometry.

C. Damen, J. Schellens, H. Rosing, 2008, Journal of pharmaceutical and biomedical analysis.

Exposure–response analyses of BRAF- and MEK-inhibitors dabrafenib plus trametinib in melanoma patients

H. Rosing, C. Blank, J. Haanen, 2023, Cancer Chemotherapy and Pharmacology.

Phase 1 study of combination treatment with PTK 787/ZK 222584 and cetuximab for patients with advanced solid tumors: safety, pharmacokinetics, pharmacodynamics analysis.

H. Rosing, J. Beijnen, E. Voest, 2010, Neoplasia.

Simultaneous quantification of abemaciclib and its active metabolites in human and mouse plasma by UHPLC-MS/MS.

H. Rosing, J. Beijnen, M. Tibben, 2021, Journal of Pharmaceutical and Biomedical Analysis.

Ultrasensitive Bioanalytical Assays for Cytotoxic Drugs: Focus on Locally Administered Anti-Cancer Agents

J. Schellens, H. Rosing, J. Beijnen, 2008 .

Quantification of docetaxel and its metabolites in human plasma by liquid chromatography/tandem mass spectrometry.

A. C. Dubbelman, J. Schellens, H. Rosing, 2013, Rapid communications in mass spectrometry : RCM.

Quantification of cabazitaxel, its metabolite docetaxel and the determination of the demethylated metabolites RPR112698 and RPR123142 as docetaxel equivalents in human plasma by liquid chromatography-tandem mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Simultaneous quantification of fludarabine and cyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

H. Rosing, J. Beijnen, M. Hillebrand, 2005, Rapid communications in mass spectrometry : RCM.

Characterization of Absorption, Metabolism, and Elimination of Niraparib, an Investigational Poly (ADP-Ribose) Polymerase Inhibitor, in Cancer Patients

J. Schellens, H. Rosing, J. Beijnen, 2017 .

IHC-based Ki67 as response biomarker to tamoxifen in breast cancer window trials enrolling premenopausal women

P. V. van Diest, H. Horlings, W. Zwart, 2021, NPJ breast cancer.

Quantitative LC-MS/MS analysis of 5-hydroxymethyl-2'-deoxyuridine to monitor the biological activity of J-binding protein.

H. Rosing, J. Beijnen, A. Perrakis, 2020, Analytical biochemistry.

Development, validation, and clinical application of a high‐performance liquid chromatography‐tandem mass spectrometry assay for the quantification of total intracellular &bgr;‐decitabine nucleotides and genomic DNA incorporated &bgr;‐decitabine and 5‐methyl‐2′‐deoxycytidine

J. Schellens, H. Rosing, J. Beijnen, 2019, Journal of pharmaceutical and biomedical analysis.

Quantitative determination of azacitidine triphosphate in peripheral blood mononuclear cells using liquid chromatography coupled with high-resolution mass spectrometry.

J. Schellens, H. Rosing, J. Beijnen, 2014, Journal of pharmaceutical and biomedical analysis.

Population pharmacokinetics of the novel anticancer agent KRN7000

G. Giaccone, C. Punt, J. Schellens, 2002, Cancer Chemotherapy and Pharmacology.

H. Rosing, H. Hawle, A. Huitema, 2016, Haematologica.

The impact of liver resection on the dihydrouracil:uracil plasma ratio in patients with colorectal liver metastases

J. Schellens, H. Rosing, J. Beijnen, 2018, European Journal of Clinical Pharmacology.

Upfront Genotyping of DPYD*2A to Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis.

J. Schellens, H. Rosing, J. Beijnen, 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Development of an LC-MS/MS assay for the quantitative determination of the intracellular 5-fluorouracil nucleotides responsible for the anticancer effect of 5-fluorouracil.

J. Schellens, H. Rosing, J. Beijnen, 2015, Journal of pharmaceutical and biomedical analysis.

R. Bernards, C. Caldas, Mariette Schrier, 2019, Clinical Cancer Research.

H. Rosing, J. Beijnen, H. Guchelaar, 2013, Clinical therapeutics.

Analytical Validation of a Volumetric Absorptive Microsampling Method for Therapeutic Drug Monitoring of the Oral Targeted Anticancer Agents, Abiraterone, Alectinib, Cabozantinib, Imatinib, Olaparib, and Sunitinib, and Metabolites.

H. Rosing, N. Steeghs, N. de Vries, 2024, Therapeutic drug monitoring.

P‐glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel

J. Schellens, H. Rosing, J. Beijnen, 2013, International journal of cancer.

Determination of sunitinib and its active metabolite N-desethylsunitinib in sweat of a patient.

J. Schellens, H. Rosing, J. Beijnen, 2011, Journal of Analytical Toxicology.

Brain Accumulation of Dasatinib Is Restricted by P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) and Can Be Enhanced by Elacridar Treatment

H. Rosing, J. Beijnen, M. Hillebrand, 2009, Clinical Cancer Research.

A phase I and pharmacokinetic study of bi-daily dosing of oral paclitaxel in combination with cyclosporin A

J. Schellens, H. Rosing, J. Beijnen, 2001, Cancer Chemotherapy and Pharmacology.