K. Steele

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Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group

Andrew H. Beck, Jacqueline A. Hall, Sarah N. Dudgeon, 2020, npj Breast Cancer.

Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothe

Carsten Denkert, Fred Hirsch, Benjamin Solomon, 2017, Advances in anatomic pathology.

Development of a programmed cell death ligand-1 immunohistochemical assay validated for analysis of non-small cell lung cancer and head and neck squamous cell carcinoma

Nicole Schechter, Xiaoping Jin, K. Steele, 2016, Diagnostic Pathology.

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

Jacqueline A. Hall, Sarah N. Dudgeon, A. Gown, 2020, npj Breast Cancer.

Safety and efficacy of MEDI4736, an anti-PD-L1 antibody, in patients from a squamous cell carcinoma of the head and neck (SCCHN) expansion cohort.

S. Ou, K. Steele, M. Rebelatto, 2015 .

Phase Ib study of MEDI4736, a programmed cell death ligand-1 (PD-L1) antibody, in combination with tremelimumab, a cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) antibody, in patients (pts) with advanced NSCLC.

K. Steele, N. Rizvi, A. Balmanoukian, 2015 .

The Society for Immunotherapy in Cancer statement on best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) staining and validation

J. Taube, I. Wistuba, Emanuel Schenck, 2020, Journal for immunotherapy of cancer.

PATHOLOGY INFORMATICS SUMMIT 2018

David E. Breen, William B. Lober, Hamid R. Tizhoosh, 2018, Journal of Pathology Informatics.

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

Andrew H. Beck, Jacqueline A. Hall, Sarah N. Dudgeon, 2020, npj Breast Cancer.

Automated image analysis of NSCLC biopsies to predict response to anti-PD-L1 therapy

K. Steele, M. Rebelatto, T. Wiestler, 2019, Journal of Immunotherapy for Cancer.

Safety and antitumour activity in a phase 1b study of combined checkpoint blockade with anti-PD-L1 (durvalumab) and anti-CTLA4 (tremelimumab) in non-small cell lung cancer

K. Steele, J. Chaft, A. Gupta, 2018 .

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts

Amanda R. Campbell, F. Lund-Johansen, Yair Benita, 2016 .

Image Analysis for Tissue Phenomics

R. Korn, M. Baatz, K. Steele, 2018 .

CTLA-4 Immunohistochemistry and Quantitative Image Analysis for Profiling of Human Cancers

K. Steele, J. Rodriguez-Canales, R. Cárdenes, 2019, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Characterization of the immune microenvironment of NSCLC by multispectral analysis of multiplex immunofluorescence images.

K. Steele, J. Rodriguez-Canales, L. Rognoni, 2020, Methods in enzymology.

Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study.

K. Steele, N. Rizvi, J. Chaft, 2016, The Lancet. Oncology.

Tertiary Lymphoid Structure-B Cells Narrow Regulatory T Cells Impact in Lung Cancer Patients

N. Girard, D. Gossot, P. Validire, 2021, Frontiers in Immunology.

Expression of PD-L1 and other immunotherapeutic targets in thymic epithelial tumors

Gregory Riely, N. Rekhtman, A. Moreira, 2017, PloS one.

Comparison of continuous measures across diagnostic PD-L1 assays in non-small cell lung cancer using automated image analysis

Tobias Wiestler, Alexei Budco, Keith Steele, 2019, Modern Pathology.

Deep Semi Supervised Generative Learning for Automated Tumor Proportion Scoring on NSCLC Tissue Needle Biopsies

K. Steele, M. Rebelatto, G. Schmidt, 2018, Scientific Reports.

Development of a PD-L1 companion diagnostic assay for treatment with MEDI4736 in NSCLC and SCCHN patients.

K. Steele, M. Rebelatto, Jill Walker, 2015 .

Safety and clinical activity of MEDI4736, an anti-programmed cell death-ligand 1 (PD-L1) antibody, in patients with non-small cell lung cancer (NSCLC).

Patrick Schöffski, Keith Steele, J. Nemunaitis, 2015 .

Defining the immunologic phenotype of thymic epithelial tumors.

C. Sima, J. Wolchok, Gregory Riely, 2015 .

103PComparison of continuous measures across diagnostic PD-L1 assays using image analysis

K. Steele, M. Rebelatto, Jill Walker, 2017 .

Measuring multiple parameters of CD8+ tumor-infiltrating lymphocytes in human cancers by image analysis

Johannes Zimmermann, Tobias Wiestler, René Korn, 2018, Journal of Immunotherapy for Cancer.

Safety and efficacy of durvalumab in patients with head and neck squamous cell carcinoma: results from a phase I/II expansion cohort.

S. Ou, K. Steele, M. Rebelatto, 2019, European journal of cancer.

Automated Multiplex Immunofluorescence Panel for Immuno-oncology Studies on Formalin-fixed Carcinoma Tissue Specimens.

Jaime Rodriguez-Canales, Chichung Wang, Kristin Roman, 2019, Journal of visualized experiments : JoVE.

The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

Andrew H. Beck, Clare C. Yu, M. N. Vidya, 2021, npj Breast Cancer.

Abstracts from the 4th ImmunoTherapy of Cancer Conference

R. Rees, F. Regnier, A. Trautmann, 2017, Journal of Immunotherapy for Cancer.

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

Jacqueline A. Hall, Sarah N. Dudgeon, A. Gown, 2020, npj Breast Cancer.

Mutually exclusive expression of CD73 and PDL1 in tumors from patients (pt) with NSCLC, gastroesophageal (GE) and urothelial bladder carcinoma (UBC).

R. Korn, Song Wu, J. Zha, 2017 .

Domain Adaptation-Based Deep Learning for Automated Tumor Cell (TC) Scoring and Survival Analysis on PD-L1 Stained Tissue Images

Nicolas Brieu, Günter Schmidt, Armin Meier, 2021, IEEE Transactions on Medical Imaging.

DASGAN - Joint Domain Adaptation and Segmentation for the Analysis of Epithelial Regions in Histopathology PD-L1 Images pdf

Nicolas Brieu, Ansh Kapil, Keith Steele, 2019, ArXiv.

Phase Ib/II study to evaluate the safety and antitumor activity of durvalumab (MEDI4736) and tremelimumab as monotherapy or in combination, in patients with recurrent or metastatic gastric/gastroesophageal junction adenocarcinoma

K. Steele, M. Rebelatto, K. Almhanna, 2015, Journal of Immunotherapy for Cancer.

Tumor response from durvalumab (MEDI4736) + tremelimumab treatment in patients with advanced non-small cell lung cancer (NSCLC) is observed regardless of PD-L1 status

K. Steele, M. Rebelatto, N. Rizvi, 2015, Journal of Immunotherapy for Cancer.

Updated safety and efficacy of durvalumab (MEDI4736), an anti-PD-L 1 antibody, in patients from a squamous cell carcinoma of the head and neck (SCCHN) expansion cohort

S. Ou, K. Steele, M. Rebelatto, 2016 .

Multiplex Immunohistochemistry for Image Analysis of Tertiary Lymphoid Structures in Cancer.

Keith E Steele, Charles Brown, K. Steele, 2018, Methods in molecular biology.

Relationship of baseline tumoral IFNγ mRNA and PD-L1 protein expression to overall survival in durvalumab-treated NSCLC patients.

K. Steele, M. Rebelatto, A. Gupta, 2016 .

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts

Amanda R. Campbell, F. Lund-Johansen, Yair Benita, 2016 .