C. Parent

发表

A cell's sense of direction.

C. Parent, P. Devreotes, C. Parent, 1999, Science.

Localization of the G protein betagamma complex in living cells during chemotaxis.

C. Parent, P. Devreotes, T. Jin, 2000, Science.

Localization of the G Protein βγ Complex in Living Cells During Chemotaxis

C. Parent, P. Devreotes, T. Jin, 2000 .

Real-Time Motion Analysis Reveals Cell Directionality as an Indicator of Breast Cancer Progression

W. Losert, C. Parent, Michael Weiger, 2013, PloS one.

Cell speed, persistence and information transmission during signal relay and collective migration

Colin McCann, W. Losert, C. Parent, 2010, Journal of Cell Science.

Chemotaxis: moving forward and holding on to the past

C. Parent, A. Bagorda, V. Mihaylov, 2005, Thrombosis and Haemostasis.

Eukaryotic chemotaxis at a glance

C. Parent, A. Bagorda, 2008, Journal of Cell Science.

G Protein Signaling Events Are Activated at the Leading Edge of Chemotactic Cells

D. Murphy, C. Parent, P. Devreotes, 1998, Cell.

A G alpha-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement.

C. Parent, A. Kimmel, J. Brzostowski, 2004, Genes & development.

LTB4 is a signal-relay molecule during neutrophil chemotaxis.

Colin McCann, W. Losert, C. Parent, 2012, Developmental cell.

Cell motility in cancer invasion and metastasis: insights from simple model organisms

Christina H. Stuelten, Carole A. Parent, C. Parent, 2018, Nature Reviews Cancer.

Collective cell migration requires vesicular trafficking for chemoattractant delivery at the trailing edge

Guofeng Zhang, Carole A. Parent, Valarie A. Barr, 2008, The Journal of cell biology.

Adenylyl Cyclase Expression and Regulation During the Differentiation of Dictyostelium Discoideum

C. Parent, P. Kriebel, 2004, IUBMB life.

Phosphoinositides in chemotaxis.

C. Parent, Michael Weiger, 2012, Sub-cellular biochemistry.

PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils

C. Parent, Lunhua Liu, Derek Gritz, 2014, Molecular biology of the cell.

Getting TANned: How the tumor microenvironment drives neutrophil recruitment

C. Parent, Bhagawat C. Subramanian, Shuvasree SenGupta, 2018, Journal of leukocyte biology.

Signal relay during chemotaxis

C. Parent, G. L. Garcia, 2008, Journal of microscopy.

Emerging roles for the nucleus during neutrophil signal relay and NETosis.

C. Parent, C. Saunders, 2019, Current opinion in cell biology.

Non-canonical processes that shape the cell migration landscape.

C. Parent, P. Coulombe, R. Majumdar, 2019, Current opinion in cell biology.

Gliadin Induces Neutrophil Migration via Engagement of the Formyl Peptide Receptor, FPR1

C. Parent, V. Casolaro, Lunhua Liu, 2015, PloS one.

Glia maturation factor‐γ mediates neutrophil chemotaxis

C. Parent, Lunhua Liu, K. Chin, 2011, Journal of leukocyte biology.

Faculty Opinions recommendation of PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects.

C. Parent, 2004 .

Enrichment of platelet phospholipids with eicosapentaenoic acid and docosahexaenoic acid inhibits thromboxane A2/prostaglandin H2 receptor binding and function.

P. Fonlupt, C. Parent, M. Lagarde, 1990, The Journal of biological chemistry.

A role for keratins in supporting mitochondrial organization and function in skin keratinocytes

C. Parent, R. Weigert, P. Coulombe, 2019, bioRxiv.

Fibrotic lung disease inhibits immune responses to staphylococcal pneumonia via impaired neutrophil and macrophage function

C. Parent, D. O’Dwyer, B. Moore, 2022, JCI insight.

The LTB4–BLT1 axis regulates actomyosin and β2-integrin dynamics during neutrophil extravasation

C. Parent, N. Melis, Bhagawat C. Subramanian, 2019, The Journal of cell biology.

The LTB4-BLT1 signaling axis coordinates actomyosin dynamics and β-2 Integrin trafficking to drive intravascular neutrophil response to infection

C. Parent, N. Melis, Bhagawat C. Subramanian, 2019, bioRxiv.

Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production.

C. Parent, W. Dubois, L. Tessarollo, 2011, Blood.

development, and antibody production Constitutive reductions in mTOR alter cell size, immune cell

C. Parent, W. Dubois, P. Schwartzberg, 2011 .

Ceramide-Rich Microdomains Facilitate Nuclear Envelope Budding during the Biogenesis of LTB4-containing Exosomes

C. Parent, Subhash B Arya, Song Chen, 2022, bioRxiv.

A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium.

R. Firtel, C. Parent, R. Insall, 1999, Molecular biology of the cell.

Assessing the role of the ASP56/CAP homologue of Dictyostelium discoideum and the requirements for subcellular localization.

C. Parent, A. Noegel, M. Schleicher, 1999, Journal of cell science.

A Gβγ effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis.

T. Veenstra, C. Parent, T. Jin, 2012, Developmental cell.

Group migration and signal relay in Dictyostelium.

C. Parent, P. Kriebel, 2009, Methods in molecular biology.

TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium.

J. Yates, R. Firtel, C. Parent, 2005, Molecular biology of the cell.

Dictyostelium discoideum cAMP Chemotaxis Pathway

C. Parent, A. Kimmel, 2003, Science's STKE.

The group migration of Dictyostelium cells is regulated by extracellular chemoattractant degradation.

C. Parent, E. Rericha, P. Goldsmith, 2009, Molecular biology of the cell.

S-adenosylhomocysteine hydrolase is localized at the front of chemotaxing cells, suggesting a role for transmethylation during migration

C. Parent, Wenli Liu, E. Korn, 2006, Proceedings of the National Academy of Sciences.

Adenylyl cyclase A mRNA localized at the back of cells is actively translated in live chemotaxing Dictyostelium

W. Losert, C. Parent, Weiye Wang, 2018, Journal of Cell Science.

Extracellular vesicles: Critical players during cell migration.

Alissa M. Weaver, C. Parent, B. Sung, 2021, Developmental cell.

Expression of Y53A-Actin in Dictyostelium Disrupts the Cytoskeleton and Inhibits Intracellular and Intercellular Chemotactic Signaling*

C. Parent, P. Kriebel, E. Korn, 2010, The Journal of Biological Chemistry.

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

Bastian R. Angermann, Ronald N. Germain, Carole A. Parent, 2013, Nature.

The role of the LTB4-BLT1 axis in chemotactic gradient sensing and directed leukocyte migration.

C. Parent, Bhagawat C. Subramanian, R. Majumdar, 2017, Seminars in immunology.

Actin Cytoskeleton and Focal Adhesions Regulate the Biased Migration of Breast Cancer Cells on Nanoscale Asymmetric Sawteeth.

W. Losert, C. Parent, J. Fourkas, 2019, ACS nano.

Ceramide-rich microdomains facilitate nuclear envelope budding for non-conventional exosome formation

C. Parent, Subhash B Arya, Song Chen, 2022, Nature Cell Biology.

TOR kinase complexes and cell migration

C. Parent, Lunhua Liu, 2011, The Journal of cell biology.

The Recruitment of Neutrophils to the Tumor Microenvironment Is Regulated by Multiple Mediators

C. Parent, Shuvasree SenGupta, L. Hein, 2021, Frontiers in Immunology.

Identification of darlin, a Dictyostelium protein with Armadillo-like repeats that binds to small GTPases and is important for the proper aggregation of developing cells.

C. Parent, P. Devreotes, D. Larochelle, 1998, Molecular biology of the cell.

Selective modulation of the human platelet thromboxane A2/prostaglandin H2 receptor by eicosapentaenoic and docosahexaenoic acids in intact platelets and solubilized platelet membranes.

C. Parent, M. Lagarde, G. L. Le Breton, 1992, The Journal of biological chemistry.

Extracellular cAMP inhibits proximal reabsorption: are plasma membrane cAMP receptors involved?

C. Parent, P. Devreotes, L. Bankir, 2002, American journal of physiology. Renal physiology.

Collective cell migration over long time scales reveals distinct phenotypes.

W. Losert, C. Parent, C. Stuelten, 2016, Convergent science physical oncology.

Dictyostelium Cells Migrate Similarly on Surfaces of Varying Chemical Composition

Colin McCann, W. Losert, C. Parent, 2014, PloS one.

ACAP-A/B Are ArfGAP Homologs in Dictyostelium Involved in Sporulation but Not in Chemotaxis

C. Parent, P. Randazzo, Pei-Wen Chen, 2010, PloS one.

Signal relay during the life cycle of Dictyostelium.

C. Parent, D. Mahadeo, 2006, Current topics in developmental biology.

A secondary disruption of the dmpA gene encoding a large membrane protein allows aggregation defective Dictyostelium rasC- cells to form multicellular structures.

C. Parent, M. Khosla, G. Spiegelman, 2006, Developmental biology.

Radil controls neutrophil adhesion and motility through β2-integrin activation

C. Parent, S. Angers, Lunhua Liu, 2012, Molecular biology of the cell.

Triple-Negative Breast Cancer Cells Recruit Neutrophils by Secreting TGF-β and CXCR2 Ligands

C. Parent, Dawen Cai, Jason Zhang, 2021, bioRxiv.

Bacterial Siderophores Hijack Neutrophil Functions

C. Parent, Bhagawat C. Subramanian, M. Dikshit, 2017, The Journal of Immunology.

mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion.

W. Losert, C. Parent, Lunhua Liu, 2010, Developmental cell.

A chemoattractant-mediated Gi-coupled pathway activates adenylyl cyclase in human neutrophils.

C. Parent, Mirkka Janka-Junttila, R. Smoot, 2006, Molecular biology of the cell.

The principles of directed cell migration

C. Parent, J. Bear, Shuvasree SenGupta, 2021, Nature Reviews Molecular Cell Biology.

Keratin 6 regulates collective keratinocyte migration by altering cell–cell and cell–matrix adhesion

C. Parent, P. Coulombe, Hans B. Liu, 2018, The Journal of cell biology.

Faculty Opinions recommendation of Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains. Studies on the PH domains of phospholipase C delta 1 and p130.

C. Parent, 2002 .

New paradigms in the establishment and maintenance of gradients during directed cell migration.

C. Parent, M. Sixt, R. Majumdar, 2014, Current opinion in cell biology.

Adenylyl cyclase mRNA localizes to the posterior of polarized DICTYOSTELIUM cells during chemotaxis

D. Larson, W. Losert, C. Parent, 2017, BMC Cell Biology.

An adaptive and versatile method to quantitate and characterize collective cell migration behaviors on complex surfaces

Brendon M. Baker, C. Parent, B. Baker, 2023, Frontiers in cell and developmental biology.

Molecular genetics of signal transduction in Dictyostelium.

C. Parent, P. Devreotes, P N Devreotes, 1996, Annual review of biochemistry.

Identification of G Protein αi Signaling Partners by Proximity Labeling Reveals a Network of Interactions that Includes PDZ-RhoGEF

C. Parent, Saji Abraham, A. Smrcka, 2021, bioRxiv.

Genetic manipulation of PLB-985 cells and quantification of chemotaxis using the underagarose assay.

C. Parent, Bhagawat C. Subramanian, C. Saunders, 2019, Methods in cell biology.

The LTB4–BLT1 axis regulates the polarized trafficking of chemoattractant GPCRs during neutrophil chemotaxis

C. Parent, Bhagawat C. Subramanian, K. Moissoglu, 2018, Journal of Cell Science.

Phosphoinositides Specify Polarity during Epithelial Organ Development

C. Parent, F. Comer, 2007, Cell.

Making all the right moves: chemotaxis in neutrophils and Dictyostelium.

C. Parent, Carole A Parent, 2004, Current opinion in cell biology.

The Signal to Move: D. discoideum Go Orienteering

Alan R. Kimmel, Carole A. Parent, C. Parent, 2003, Science.

PI 3-Kinases and PTEN How Opposites Chemoattract

Carole A. Parent, C. Parent, F. Comer, 2002, Cell.

Exosomes Mediate LTB4 Release during Neutrophil Chemotaxis

C. Parent, R. Majumdar, Aidin Tavakoli Tameh, 2016, PLoS biology.

Adenylyl Cyclase Localization Regulates Streaming during Chemotaxis

Carole A. Parent, Valarie A. Barr, C. Parent, 2003, Cell.

Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells.

R. Firtel, C. Parent, P. Devreotes, 2003, Molecular biology of the cell.

Visualizing PI3 Kinase-Mediated Cell-Cell Signaling during Dictyostelium Development

D. Dormann, Gerti Weijer, C. Weijer, 2002, Current Biology.

Cell Migration: Sinking in a Gradient

C. Parent, K. Moissoglu, R. Majumdar, 2014, Current Biology.

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS Discoidin domain receptor 2 regulates neutrophil chemotaxis in 3D collagen matrices

Colin McCann, C. Parent, Senta M Kapnick, 2017 .

Extracellular vesicles direct migration by synthesizing and releasing chemotactic signals

C. Parent, P. Kriebel, L. Jenkins, 2018, The Journal of cell biology.

Phosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relay

C. Parent, A. Kimmel, S. Sawai, 2013, Journal of Cell Science.

Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium.

R. Firtel, C. Parent, P. Devreotes, 1997, Developmental biology.

Ras-mediated activation of the TORC2–PKB pathway is critical for chemotaxis

C. Parent, P. Devreotes, Y. Long, 2010, The Journal of cell biology.

TGF-β1 activates neutrophil signaling and gene expression but not migration

C. Parent, Shuvasree SenGupta, Craig Johnson, 2023, bioRxiv.

The PI3K-Mediated Activation of CRAC Independently Regulates Adenylyl Cyclase Activation and Chemotaxis

C. Parent, F. Comer, Joseph J. Masbad, 2005, Current Biology.

The interplay of cell–cell and cell–substrate adhesion in collective cell migration

Sagar Chowdhury, Chenlu Wang, Wolfgang Losert, 2014, Journal of The Royal Society Interface.

Asymmetric nanotopography biases cytoskeletal dynamics and promotes unidirectional cell guidance

W. Losert, C. Parent, J. Fourkas, 2015, Proceedings of the National Academy of Sciences.

Cell Shape Dynamics: From Waves to Migration

Wolfgang Losert, John T. Fourkas, Meghan K. Driscoll, 2011, PLoS Comput. Biol..

Regulation of Adenylyl Cyclases by a Region Outside the Minimally Functional Cytoplasmic Domains*

C. Parent, P. Devreotes, J. Borleis, 2002, The Journal of Biological Chemistry.

A High-Throughput, Multi-Cell Phenotype Assay for the Identification of Novel Inhibitors of Chemotaxis/Migration

Noel Southall, Wei Zheng, C. Parent, 2016, Scientific Reports.

PI3K and Chemotaxis: A Priming Issue?

C. Parent, P. Afonso, Philippe V. Afonso, 2011, Science Signaling.

Steering in Quadruplet: The Complex Signaling Pathways Directing Chemotaxis

Carole A. Parent, C. Parent, E. Rericha, 2008, Science Signaling.

Phosphoinositide 3-kinase activity controls the chemoattractant-mediated activation and adaptation of adenylyl cyclase.

C. Parent, F. Comer, 2005, Molecular biology of the cell.

Lysophosphatidic acid regulates the motility of MCF10CA1a breast cancer cell sheets via two opposing signaling pathways.

W. Losert, C. Parent, C. Stuelten, 2018, Cellular signalling.

Modeling neutrophil migration in dynamic chemoattractant gradients: assessing the role of exosomes during signal relay

R. Nossal, C. Parent, R. Majumdar, 2017, Molecular biology of the cell.

A network of Gαi signaling partners is revealed by proximity labeling proteomics analysis and includes PDZ-RhoGEF

C. Parent, Saji Abraham, A. Smrcka, 2022, Science Signaling.

Selenocysteine tRNA identification in the model organisms Dictyostelium discoideum and Tetrahymena thermophila.

V. Gladyshev, C. Parent, B. Carlson, 2005, Biochemical and biophysical research communications.

Direct Biochemical Measurements of Signal Relay during Dictyostelium Development*

C. Parent, E. Rericha, A. Bagorda, 2011, The Journal of Biological Chemistry.

The ins-and-outs of exosome biogenesis, secretion, and internalization.

C. Parent, Subhash B Arya, Samuel P. Collie, 2023, Trends in cell biology.

Exosomes mediate LTB4 release during neutrophil chemotaxis

C. Parent, R. Majumdar, Subhash B Arya, 2021, PLoS biology.

Collective cell migration requires vesicular trafficking for chemoattractant delivery at the trailing edge

C. Parent, V. Barr, P. Kriebel, 2008, The Journal of cell biology.

Real-time measurements of cAMP production in live Dictyostelium cells

C. Parent, E. Rericha, A. Bagorda, 2009, Journal of Cell Science.

Tail chimeras of Dictyostelium myosin II support cytokinesis and other myosin II activities but not full development

C. Parent, T. Uyeda, E. Korn, 2002, Journal of Cell Science.