P. V. van Haastert

发表

Biased random walk by stochastic fluctuations of chemoattractant-receptor interactions at the lower limit of detection.

P. V. van Haastert, M. Postma, 2007, Biophysical journal.

Uniform cAMP stimulation of Dictyostelium cells induces localized patches of signal transduction and pseudopodia.

P. V. van Haastert, M. Postma, J. Roelofs, 2003, Molecular biology of the cell.

Evidence that the rate of association of adenosine 3',5'-monophosphate to its chemotactic receptor induces phosphodiesterase activity in Dictyostelium discoideum

P. V. van Haastert, R. van der Meer, T. M. Konijn, 1981, Journal of bacteriology.

Reduced protein diffusion rate by cytoskeleton in vegetative and polarized dictyostelium cells.

D. Wiersma, P. V. van Haastert, P. V. Haastert, 2001, Biophysical journal.

A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover

P. V. van Haastert, R. Gallardo, W. Versées, 2017, Nature Communications.

Intramolecular Activation Mechanism of the Dictyostelium LRRK2 Homolog Roco Protein GbpC*

P. V. van Haastert, A. Kortholt, Wouter N. van Egmond, 2008, Journal of Biological Chemistry.

Dual regulation of a Dictyostelium STAT by cGMP and Ca2+ signalling

P. V. van Haastert, Jeffrey G. Williams, Wouter N. van Egmond, 2010, Journal of Cell Science.

University of Groningen Localization of Chemoattractant Receptors on Dictyostelium discoideum Cells during Aggregation and Down-regulation Wang,

P. Devreotes, P. V. van Haastert, P. Schaap, 2003 .

Phospholipase C in Dictyostelium discoideum. Cyclic AMP surface receptor and G-protein-regulated activity in vitro.

P. V. van Haastert, P. V. Haastert, A. Bominaar, 1994, The Biochemical journal.

A diffusion-translocation model for gradient sensing by chemotactic cells.

P. V. van Haastert, M. Postma, 2001, Biophysical journal.

Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis

P. V. van Haastert, A. Kortholt, I. Keizer-Gunnink, 2007, The Journal of cell biology.

Sensitization of Dictyostelium chemotaxis by phosphoinositide-3-kinase-mediated self-organizing signalling patches

Joachim Goedhart, Marten Postma, P. V. van Haastert, 2004, Journal of Cell Science.

PI3-kinase signaling contributes to orientation in shallow gradients and enhances speed in steep chemoattractant gradients

P. V. van Haastert, Leonard Bosgraaf, I. Keizer-Gunnink, 2008, Journal of Cell Science.

Characterization of Two Unusual Guanylyl Cyclases fromDictyostelium *

P. V. van Haastert, J. Roelofs, Peter J M Van Haastert, 2002, The Journal of Biological Chemistry.

GTPγS Regulation of a 12-Transmembrane Guanylyl Cyclase Is Retained after Mutation to an Adenylyl Cyclase*

P. V. van Haastert, J. Roelofs, H. Loovers, 2001, The Journal of Biological Chemistry.

Chemotaxis: insights from the extending pseudopod

P. V. van Haastert, Peter J M Van Haastert, 2010, Journal of Cell Science.

The local cell curvature guides pseudopodia towards chemoattractants

P. V. van Haastert, Leonard Bosgraaf, Peter J. M. Van Haastert, 2009, HFSP journal.

Cultivation of immobilized Dictyostelium discoideum for the production of soluble human Fas ligand

P. V. van Haastert, Yinghua Lu, K. Friehs, 2004, Applied Microbiology and Biotechnology.

Protection Against Osmotic Stress by cGMP-Mediated Myosin Phosphorylation

P. V. van Haastert, M. Ecke, Günther Gerisch, 1996, Science.

Unified control of amoeboid pseudopod extension in multiple organisms by branched F-actin in the front and parallel F-actin/myosin in the cortex

P. V. van Haastert, 2020, PloS one.

Food Searching Strategy of Amoeboid Cells by Starvation Induced Run Length Extension

P. V. van Haastert, Leonard Bosgraaf, Peter J. M. Van Haastert, 2009, PloS one.

Ras activation and symmetry breaking during Dictyostelium chemotaxis

P. V. van Haastert, A. Kortholt, I. Keizer-Gunnink, 2013, Journal of Cell Science.

G-proteins in the signal-transduction pathways of Dictyostelium discoideum.

P. V. van Haastert, B. Snaar-Jagalska, P. V. Haastert, 1988, Developmental genetics.

Differential effects of temperature on cAMP-induced excitation, adaptation, and deadaptation of adenylate and guanylate cyclase in Dictyostelium discoideum

P. V. van Haastert, P. V. Haastert, Van Haastert, 1987, The Journal of cell biology.

The regulation of adenylate cyclase by guanine nucleotides in Dictyostelium discoideum membranes.

P. V. van Haastert, B. Snaar-Jagalska, P. V. Haastert, 1987, European journal of biochemistry.

The regulation of myosin II in Dictyostelium.

P. V. van Haastert, Leonard Bosgraaf, L. Bosgraaf, 2006, European journal of cell biology.

Evidence for a messenger function of cyclic GMP during phosphodiesterase induction in Dictyostelium discoideum

P. V. van Haastert, R. van der Meer, T. M. Konijn, 1982, Journal of bacteriology.

Myosin light chain kinase A is activated by cGMP‐dependent and cGMP‐independent pathways

P. V. van Haastert, J. Goldberg, Janet L. Smith, 2006, FEBS letters.

Rap1-dependent pathways coordinate cytokinesis in Dictyostelium

P. V. van Haastert, A. Kortholt, Katarzyna Plak, 2014, Molecular biology of the cell.

Agonist‐stimulated high‐affinity GTPase in Dictyostelium membranes

K. Jakobs, P. V. van Haastert, B. Snaar-Jagalska, 1988, FEBS letters.

Cyclic GMP binding activity in Dictyostelium discoideum

P. V. van Haastert, T. M. Konijn, J. Mato, 1978, FEBS letters.

Expression of a mutated ras gene in Dictyostelium discoideum alters the binding of cyclic AMP to its chemotactic receptor.

P. V. van Haastert, R. van Driel, P. V. Haastert, 1988, Journal of cell science.

A Model for a Correlated Random Walk Based on the Ordered Extension of Pseudopodia

P. V. van Haastert, 2010, PLoS computational biology.

Characterization of the Roco Protein Family in Dictyostelium discoideum

P. V. van Haastert, Wouter N. van Egmond, Peter J. M. van Haastert, 2010, Eukaryotic Cell.

Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells

P. V. van Haastert, Henderikus Pots, A. Kortholt, 2016, BMC Cell Biology.

A Gα-Stimulated RapGEF Is a Receptor-Proximal Regulator of Dictyostelium Chemotaxis.

R. Firtel, P. V. van Haastert, J. Lacal, 2016, Developmental cell.

Inhibitory action of certain cyclophosphate derivatives of cAMP on cAMP-dependent protein kinases.

W. Stec, P. V. van Haastert, D. Hekstra, 1984, European journal of biochemistry.

Transduction of the chemotactic cAMP signal across the plasma membrane ofDictyostelium cells

P. V. van Haastert, Van Haastert, 1995, Experientia.

Selective induction of gene expression and second-messenger accumulation in Dictyostelium discoideum by the partial chemotactic antagonist 8-p-chlorophenylthioadenosine 3',5'-cyclic monophosphate.

J. Williams, P. V. van Haastert, B. Snaar-Jagalska, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Measurement of chemotaxis in Dictyostelium.

P. V. van Haastert, T. M. Konijn, 1987, Methods in cell biology.

Intramolecular Activation Mechanism of the Dictyostelium LRRK2 Homolog Roco Protein GbpC*

P. V. van Haastert, A. Kortholt, Wouter N. van Egmond, 2008, Journal of Biological Chemistry.

A sensitive cyclic nucleotide phosphodiesterase assay for transient enzyme kinetics.

P. V. van Haastert, M. M. van Lookeren Campagne, 1983, Analytical biochemistry.

Production of the soluble human Fas ligand by Dictyostelium discoideum cultivated on a synthetic medium.

P. V. van Haastert, Yinghua Lu, K. Friehs, 2004, Journal of biotechnology.

Cyclic AMP signalling in Dictyostelium: G‐proteins activate separate Ras pathways using specific RasGEFs

P. V. van Haastert, G. Spiegelman, R. Insall, 2007, EMBO reports.

DdPDE4, a Novel cAMP-specific Phosphodiesterase at the Surface of Dictyostelium Cells*

P. V. van Haastert, A. Kortholt, S. Bader, 2006, Journal of Biological Chemistry.

Identification and characterization of DdPDE3, a cGMP-selective phosphodiesterase from Dictyostelium.

P. V. van Haastert, J. Roelofs, H. Kuwayama, 2001, The Biochemical journal.

Dictyostelium discoideum mutant synag 7 with altered G-protein-adenylate cyclase interaction.

P. V. van Haastert, B. Snaar-Jagalska, P. V. Haastert, 1988, Journal of cell science.

Pertussis toxin inhibits cAMP surface receptor‐stimulated binding of [35S]GTPγS to Dictyostelium discoideum membranes

P. V. van Haastert, B. Snaar-Jagalska, R. de Wit, 1988 .

Aberrant transmembrane signal transduction in Dictyostelium cells expressing a mutated ras gene.

R. Firtel, P. V. van Haastert, R. van Driel, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Stereospecificity of inositol hexakisphosphate dephosphorylation by Paramecium phytase.

P. V. van Haastert, J. van der Kaay, 1995, The Biochemical journal.

Identification and characterization of two unusual cGMP-stimulated phoshodiesterases in dictyostelium.

P. V. van Haastert, Leonard Bosgraaf, Joyce Wind, 2002, Molecular biology of the cell.

Navigation of Chemotactic Cells by Parallel Signaling to Pseudopod Persistence and Orientation

P. V. van Haastert, Leonard Bosgraaf, Peter J. M. Van Haastert, 2009, PloS one.

The Ordered Extension of Pseudopodia by Amoeboid Cells in the Absence of External Cues

P. V. van Haastert, Leonard Bosgraaf, Peter J. M. Van Haastert, 2009, PloS one.

Normal chemotaxis in Dictyostelium discoideum cells with a depolarized plasma membrane potential.

D. Ypey, P. V. van Haastert, B. van Duijn, 1990, Journal of cell science.

The binding of cyclic nucleotide analogs to a purified cyclic GMP-stimulated phosphodiesterase from bovine adrenal tissue.

P. V. van Haastert, F. Miot, C. Erneux, 1985, Journal of cyclic nucleotide and protein phosphorylation research.

Postaggregative differentiation induction by cyclic AMP in Dictyostelium: intracellular transduction pathway and requirement for additional stimuli.

P. V. van Haastert, R. van Driel, P. Schaap, 1986, Developmental biology.

Cyclic AMP and folic acid mediated cyclic GMP accumulation in Dictyostelium discoideum

P. V. van Haastert, T. M. Konijn, F. Krens, 1977, FEBS letters.

Cyclic nucleotide specificity of the activator and catalytic sites of a cGMP-stimulated cGMP phosphodiesterase from Dictyostelium discoideum.

W. Stec, P. V. van Haastert, F. Seela, 1985, European journal of biochemistry.

Transient kinetics of a cGMP-dependent cGMP-specific phosphodiesterase from Dictyostelium discoideum

P. V. van Haastert, M. M. van Lookeren Campagne, 1984, The Journal of cell biology.

Specificity of cGMP binding to a purified cGMP-stimulated phosphodiesterase from bovine adrenal tissue.

P. V. van Haastert, F. Miot, C. Erneux, 1985, European journal of biochemistry.

Competitive cAMP antagonists for cAMP-receptor proteins.

W. Stec, P. V. van Haastert, R. van Driel, 1984, The Journal of biological chemistry.

Substrate specificity of cyclic nucleotide phosphodiesterase from beef heart and from Dictyostelium discoideum.

P. V. van Haastert, T. M. Konijn, P. V. Haastert, 1983, European journal of biochemistry.

Kinetics and nucleotide specificity of a surface cAMP binding site in Dictyostelium discoideum, which is not down-regulated by cAMP.

P. V. van Haastert, P. Schaap, B. Jastorff, 1991, FEMS microbiology letters.

Phosphodiesterase induction in Dictyostelium discoideum by inhibition of extracellular phosphodiesterase activity.

P. V. van Haastert, T. M. Konijn, P. V. Haastert, 1982, Developmental biology.

Analogs of cyclic AMP as chemoattractants and inhibitors of Dictyostelium chemotaxis

P. V. van Haastert, T. M. Konijn, P. V. Haastert, 1982, Journal of bacteriology.

cGMP as second messenger during Dictyostelium chemotaxis

P. V. van Haastert, H. Kuwayama, 1997, FEBS letters.

Regulation of Guanylyl Cyclase by a cGMP-binding Protein during Chemotaxis in Dictyostelium discoideum *

P. V. van Haastert, H. Kuwayama, 1996, The Journal of Biological Chemistry.

Phospholipase Cδ regulates germination of Dictyostelium spores

P. V. van Haastert, P. van Dijken, 2001, BMC Cell Biology.

Deducing the origin of soluble adenylyl cyclase, a gene lost in multiple lineages.

P. V. van Haastert, J. Roelofs, 2002, Molecular biology and evolution.

Unusual Guanylyl Cyclases and cGMP Signaling in Dictyostelium discoideum.

P. V. van Haastert, Douwe M Veltman, Leonard Bosgraaf, 2004, Vitamins and hormones.

cGMP signalling: different ways to create a pathway.

P. V. van Haastert, Janet L. Smith, J. Roelofs, 2003, Trends in genetics : TIG.

Guanylate cyclase in Dictyostelium discoideum with the topology of mammalian adenylate cyclase.

P. V. van Haastert, P. V. Haastert, J. Roelofs, 2001, The Biochemical journal.

Chemoattractant-stimulated calcium influx in Dictyostelium discoideum does not depend on cGMP.

J. de Boer, P. V. van Haastert, Douwe M Veltman, 2003, Biochimica et biophysica acta.

A novel cGMP signalling pathway mediating myosin phosphorylation and chemotaxis in Dictyostelium

D. Soll, P. V. van Haastert, D. Wessels, 2002, EMBO Journal.

Identification of four candidate cGMP targets in Dictyostelium

P. V. van Haastert, J. Goldberg, Janet L. Smith, 2002, Proceedings of the National Academy of Sciences of the United States of America.

The Dictyostelium homologue of mammalian soluble adenylyl cyclase encodes a guanylyl cyclase

P. V. van Haastert, J. Roelofs, M. Meima, 2001, The EMBO journal.

Chemotactic and osmotic signals share a cGMP transduction pathway in Dictyostelium discoideum

P. V. van Haastert, H. Kuwayama, 1998, FEBS letters.

cGMP potentiates receptor-stimulated Ca2+ influx in Dictyostelium discoideum.

P. V. van Haastert, H. Kuwayama, 1998, Biochimica et biophysica acta.

University of Groningen Phosphorylation of chemoattractant receptors is not essential for chemotaxis or termination of G-protein-mediated responses

P. Devreotes, P. V. van Haastert, Ji-Yun Kim, 2017 .

The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium

P. Devreotes, P. V. van Haastert, P. V. Haastert, 1995, The Journal of cell biology.

Inhibition of receptor-stimulated guanylyl cyclase by intracellular calcium ions in Dictyostelium cells.

P. V. van Haastert, P. V. Haastert, R. Valkema, 1992, Biochemical and biophysical research communications.

G-protein-mediated interconversions of cell-surface cAMP receptors and their involvement in excitation and desensitization of guanylate cyclase in Dictyostelium discoideum.

J. Degoede, P. V. van Haastert, P. V. Haastert, 1986, The Journal of biological chemistry.

3':5'-cyclic AMP-dependent 3':5'-cyclic GMP accumulation in Dictyostelium discoideum.

P. V. van Haastert, T. M. Konijn, F. Krens, 1977, Proceedings of the National Academy of Sciences of the United States of America.

RasGEF-containing proteins GbpC and GbpD have differential effects on cell polarity and chemotaxis in Dictyostelium

D. Soll, P. V. van Haastert, D. Wessels, 2005, Journal of Cell Science.

Independent control of locomotion and orientation during Dictyostelium discoideum chemotaxis.

P. V. van Haastert, B. van Duijn, 1992, Journal of cell science.

The role of cGMP and the rear of the cell in Dictyostelium chemotaxis and cell streaming

P. V. van Haastert, Douwe M Veltman, 2008, Journal of Cell Science.

A density-sensing factor regulates signal transduction in Dictyostelium

R. Gomer, P. V. van Haastert, Van Haastert, 1995, The Journal of cell biology.

A new set of small, extrachromosomal expression vectors for Dictyostelium discoideum.

P. V. van Haastert, Douwe M Veltman, Leonard Bosgraaf, 2009, Plasmid.

Highlighting the role of Ras and Rap during Dictyostelium chemotaxis.

P. V. van Haastert, A. Kortholt, 2008, Cellular signalling.

University of Groningen Molecular Basis of Transmembrane Signal Transduction in Dictyostelium discoideum

P. V. van Haastert, P. V. Haastert, P. Janssens, 2022 .

Chemotaxis: signalling modules join hands at front and tail

Marten Postma, P. V. van Haastert, M. Postma, 2004, EMBO reports.

A Receptor-associated Protein/Phosphatidylinositol 3-Kinase Pathway Controls Pseudopod Formation

A. Wittinghofer, P. V. van Haastert, H. Rehmann, 2010, Molecular Biology of the Cell.

A Rap/phosphatidylinositol 3-kinase pathway controls pseudopod formation [corrected].

A. Wittinghofer, P. V. van Haastert, H. Rehmann, 2010, Molecular biology of the cell.

Seven Dictyostelium discoideum phosphodiesterases degrade three pools of cAMP and cGMP.

Arjan Kortholt, P. V. van Haastert, A. Kortholt, 2007, The Biochemical journal.

Characterization of the GbpD-activated Rap1 Pathway Regulating Adhesion and Cell Polarity in Dictyostelium discoideum*

A. Wittinghofer, P. V. van Haastert, H. Rehmann, 2006, Journal of Biological Chemistry.

Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations

I. Vetter, A. Wittinghofer, P. V. van Haastert, 2012, Proceedings of the National Academy of Sciences.

Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase

A. Wittinghofer, P. V. van Haastert, M. Weyand, 2008, The EMBO journal.

Paxillin is required for cell-substrate adhesion, cell sorting and slug migration during Dictyostelium development

Cornelis J. Weijer, Dirk Dormann, D. Dormann, 2005, Journal of Cell Science.

Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium.

R. Firtel, P. V. van Haastert, P. Schaap, 1993, The Journal of biological chemistry.

Regulation of Phagocytosis in Dictyostelium by the Inositol 5‐Phosphatase OCRL Homolog Dd5P4

R. Nussbaum, P. V. van Haastert, A. Kortholt, 2007, Traffic.

A Diverse Family of Inositol 5-Phosphatases Playing a Role in Growth and Development in Dictyostelium discoideum * 210

P. V. van Haastert, X. Pesesse, C. Erneux, 2003, The Journal of Biological Chemistry.

How Cells Use Pseudopods for Persistent Movement and Navigation

P. V. van Haastert, Peter J. M. van Haastert, 2011, Science Signaling.

Phospholipase C activity in Dictyostelium discoideum using endogenous nonradioactive phosphatidylinositol 4,5-bisphosphate as substrate.

P. V. van Haastert, A. Bominaar, 1994, Methods in enzymology.

Abberant chemotaxis and differentiation in Dictyostelium mutant fgdC with a defective regulation of receptor-stimulated phosphoinositidase C.

P. V. van Haastert, B. Snaar-Jagalska, D. Peters, 1991, Journal of cell science.

A competition binding assay for determination of the inositol (1,4,5)-trisphosphate content of human leucocytes.

P. V. van Haastert, P. Nibbering, R. van Furth, 1990, Biochemical and biophysical research communications.

Transmethylation inhibitors decrease chemotactic sensitivity and delay cell aggregation in Dictyostelium discoideum

P. V. van Haastert, A. van Waarde, 1984, Journal of bacteriology.

Dictyostelium discoideum contains three inositol monophosphatase activities with different substrate specificities and sensitivities to lithium.

P. V. van Haastert, J. van der Kaay, J. Bergsma, 1996, The Biochemical journal.

Short- and long-term memory of moving amoeboid cells.

P. V. van Haastert, 2021, PloS one.

A stochastic model for chemotaxis based on the ordered extension of pseudopods.

P. V. van Haastert, Peter J M Van Haastert, 2010, Biophysical journal.

Guanylyl cyclase protein and cGMP product independently control front and back of chemotaxing Dictyostelium cells.

P. V. van Haastert, Douwe M Veltman, 2006, Molecular biology of the cell.

The Phosducin-Like Protein PhLP1 Is Essential for Gβγ Dimer Formation in Dictyostelium discoideum

P. V. van Haastert, A. Visser, J. Knol, 2005, Molecular and Cellular Biology.

Regulatory properties of magnesium-dependent guanylate cyclase in Dictyostelium discoideum membranes.

P. V. van Haastert, P. V. Haastert, P. Janssens, 1989, The Journal of biological chemistry.

Altered cGMP‐phosphodiesterase activity in chemotactic mutants of Dictyostelium discoideum

P. V. van Haastert, M. M. van Lookeren Campagne, F. M. Ross, 1982, FEBS letters.

Chemoattractant and guanosine 5'-[gamma-thio]triphosphate induce the accumulation of inositol 1,4,5-trisphosphate in Dictyostelium cells that are labelled with [3H]inositol by electroporation.

P. V. van Haastert, J. van der Kaay, L. Penning, 1989, The Biochemical journal.

The cyclic nucleotide specificity of three cAMP receptors in Dictyostelium.

B Jastorff, P. Devreotes, P. V. van Haastert, 1992, The Journal of biological chemistry.

Binding of cAMP derivatives to Dictyostelium discoideum cells. Activation mechanism of the cell surface cAMP receptor.

P. V. van Haastert, Van Haastert, P J Van Haastert, 1983, The Journal of biological chemistry.

Phosducin‐like proteins in Dictyostelium discoideum: implications for the phosducin family of proteins

Marten Postma, P. V. van Haastert, J. Roelofs, 2003, The EMBO journal.

Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis

P. V. van Haastert, T. Jin, F. Fusetti, 2013, Proceedings of the National Academy of Sciences.

Activation of a pertussis-toxin-sensitive guanine-nucleotide-binding regulatory protein during desensitization of Dictyostelium discoideum cells to chemotactic signals.

P. V. van Haastert, B. Snaar-Jagalska, P. V. Haastert, 1991, European journal of biochemistry.

Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling

P. V. van Haastert, A. Kortholt, I. Keizer-Gunnink, 2007, The Journal of cell biology.

Four key signaling pathways mediating chemotaxis in Dictyostelium discoideum

P. V. van Haastert, Douwe M Veltman, Ineke Keizer-Gunnik, 2008, The Journal of cell biology.

Lithium ions induce prestalk-associated gene expression and inhibit prespore gene expression in Dictyostelium discoideum.

P. V. van Haastert, D. Peters, P. Schaap, 1989, Journal of cell science.

Lithium, an inhibitor of cAMP-induced inositol 1,4,5-trisphosphate accumulation in Dictyostelium discoideum, inhibits activation of guanine-nucleotide-binding regulatory proteins, reduces activation of adenylylcyclase, but potentiates activation of guanylyl cyclase by cAMP.

P. V. van Haastert, B. Snaar-Jagalska, D. Peters, 1992, European journal of biochemistry.

Nucleus-associated phosphorylation of Ins(1,4,5)P3 to InsP6 in Dictyostelium.

P. V. van Haastert, J. van der Kaay, J. Wesseling, 1995, The Biochemical journal.

Chemotaxis: A Feedback-Based Computational Model Robustly Predicts Multiple Aspects of Real Cell Behaviour

John A. Mackenzie, Steven D. Webb, Robert H. Insall, 2011, PLoS biology.

Switching direction in electric-signal-induced cell migration by cyclic guanosine monophosphate and phosphatidylinositol signaling

Masayuki J. Sato, T. Yanagida, M. Ueda, 2009, Proceedings of the National Academy of Sciences.

Roc, a Ras/GTPase domain in complex proteins.

P. V. van Haastert, Leonard Bosgraaf, L. Bosgraaf, 2003, Biochimica et biophysica acta.

Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase.

P. Devreotes, P. V. van Haastert, M. Postma, 2006, Molecular biology of the cell.

The small GTPases Ras and Rap1 bind to and control TORC2 activity

Pascale G. Charest, S. Briggs, P. V. van Haastert, 2016, Scientific Reports.

GxcC connects Rap and Rac signaling during Dictyostelium development

P. V. van Haastert, Douwe M Veltman, F. Rivero, 2013, BMC Cell Biology.

Amoeboid Cells Use Protrusions for Walking, Gliding and Swimming

P. V. van Haastert, 2011, PloS one.

Analysis of cell movement by simultaneous quantification of local membrane displacement and fluorescent intensities using Quimp2.

Till Bretschneider, P. V. van Haastert, T. Bretschneider, 2009, Cell motility and the cytoskeleton.

Phospholipase C regulation of phosphatidylinositol 3,4,5-trisphosphate-mediated chemotaxis.

P. V. van Haastert, A. Harwood, A. Kortholt, 2007, Molecular biology of the cell.

Coupled excitable Ras and F-actin activation mediates spontaneous pseudopod formation and directed cell movement

P. V. van Haastert, A. Kortholt, I. Keizer-Gunnink, 2017, Molecular biology of the cell.

Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification

P. V. van Haastert, A. Kortholt, Wouter N. van Egmond, 2011, EMBO reports.

Symmetry Breaking during Cell Movement in the Context of Excitability, Kinetic Fine-Tuning and Memory of Pseudopod Formation

P. V. van Haastert, 2020, Cells.

Spectral characterization of Dictyostelium autofluorescence

P. V. van Haastert, A. Visser, R. Engel, 2006, Microscopy research and technique.

University of Groningen PI 3-kinase signaling contributes to orientation in shallow gradients and enhances speed in steep chemoattractant gradients

P. V. van Haastert, Bosgraaf, 2017 .

cAMP-induced desensitization of surface cAMP receptors in Dictyostelium: different second messengers mediate receptor phosphorylation, loss of ligand binding, degradation of receptor, and reduction of receptor mRNA levels.

P. Devreotes, P. V. van Haastert, P. Schaap, 1992, Molecular biology of the cell.

Overexpression of the cAMP receptor 1 in growing Dictyostelium cells.

M. Caterina, P. Devreotes, P. V. van Haastert, 1991, Biochemistry.

Antagonists of chemoattractants reveal separate receptors for cAMP, folic acid and pterin in Dictyostelium.

P. V. van Haastert, T. M. Konijn, P. V. Haastert, 1982, Experimental cell research.

Phospholipase-C-independent inositol 1,4,5-trisphosphate formation in Dictyostelium cells. Activation of a plasma-membrane-bound phosphatase by receptor-stimulated Ca2+ influx.

P. V. van Haastert, P. V. Haastert, J. Bergsma, 1997, European journal of biochemistry.

Chemotaxis: Navigating by Multiple Signaling Pathways

P. V. van Haastert, Douwe M Veltman, 2007, Science's STKE.

Desalting inositolpolyphosphates by dialysis.

P. V. van Haastert, J. van der Kaay, 1995, Analytical Biochemistry.

A novel Myb homolog initiates Dictyostelium development by induction of adenylyl cyclase expression.

P. V. van Haastert, H. Otsuka, 1998, Genes & development.

A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells

Elisabeth Wong, Guillaume Charras, Bashar Hamza, 2016, PloS one.

University of Groningen Signal Transduction in Dictyostelium fgd A Mutants with a Defective Interaction between Surface cAMP Receptors and a GTP-binding Regulatory Protein

P. V. van Haastert, F. Kesbeke, Van Haastert, 2018 .

Phospholipase C in Dictyostelium discoideum. Identification of stimulatory and inhibitory surface receptors and G-proteins.

P. V. van Haastert, A. Bominaar, 1994, The Biochemical journal.

Developmental regulation of the inositol 1,4,5-trisphosphate phosphatases in Dictyostelium discoideum.

P. V. van Haastert, R. Draijer, A. Bominaar, 1991, Differentiation; research in biological diversity.

cAMP pulses coordinate morphogenetic movement during fruiting body formation of Dictyostelium minutum.

P. V. van Haastert, T. M. Konijn, P. Schaap, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Real-time visualization of intracellular hydrodynamics in single living cells.

D. Wiersma, P. V. van Haastert, P. V. Haastert, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Surface cAMP receptors mediate multiple responses during development in Dictyostelium: evidenced by antisense mutagenesis

P. Devreotes, P. V. van Haastert, T. Sun, 1990, The Journal of cell biology.

Chemotactic antagonists of cAMP inhibit Dictyostelium phospholipase C.

P. V. van Haastert, A. Bominaar, 1993, Journal of cell science.

Binding of cAMP and adenosine derivatives to Dictyostelium discoideum cells. Relationships of binding, chemotactic, and antagonistic activities.

P. V. van Haastert, 1983, The Journal of biological chemistry.

Demonstration of receptor heterogeneity and affinity modulation by nonequilibrium binding experiments. The cell surface cAMP receptor of Dictyostelium discoideum.

P. V. van Haastert, R. de Wit, 1984, The Journal of biological chemistry.

Reduced cAMP secretion in Dictyostelium discoideum mutant HB3.

P. V. van Haastert, P. V. Haastert, F. Kesbeke, 1988, Developmental biology.

Transmembrane signal transduction pathways in Dictyostelium.

P. V. van Haastert, 1991, Advances in second messenger and phosphoprotein research.

Combined FCS and PCH Analysis to Quantify Protein Dimerization in Living Cells

P. V. van Haastert, J. Borst, A. Westphal, 2021, International journal of molecular sciences.

Phosphorylation of inositol 1,4,5-trisphosphate analogues by 3-kinase and dephosphorylation of inositol 1,3,4,5-tetrakisphosphate analogues by 5-phosphatase.

P. V. van Haastert, B. Potter, C. Erneux, 1994, European journal of biochemistry.

Mathematics of experimentally generated chemoattractant gradients.

Marten Postma, P. V. van Haastert, 2009, Methods in molecular biology.

The cytoskeleton regulates symmetry transitions in moving amoeboid cells

P. V. van Haastert, A. Kortholt, I. Keizer-Gunnink, 2018, Journal of Cell Science.

Biochemistry and genetics of inositol phosphate metabolism in Dictyostelium

P. V. van Haastert, P. van Dijken, Peter van Dijken, 1997, FEBS letters.

Analysis of signal transduction: formation of cAMP, cGMP, and Ins(1,4,5)P3 in vivo and in vitro.

P. V. van Haastert, 2006, Methods in molecular biology.

Mutation of an EF-hand Ca(2+)-binding motif in phospholipase C of Dictyostelium discoideum: inhibition of activity but no effect on Ca(2+)-dependence.

P. V. van Haastert, M. Meima, A. Drayer, 1995, The Biochemical journal.

Molecular cloning and expression of a phosphoinositide-specific phospholipase C of Dictyostelium discoideum.

P. V. van Haastert, A. Drayer, 1992, The Journal of biological chemistry.

Multiple Regulatory Mechanisms for the Dictyostelium Roco Protein GbpC

P. V. van Haastert, A. Kortholt, Wouter N. van Egmond, 2011, The Journal of Biological Chemistry.

Mathematics of Experimentally Generated Chemoattractant Gradients.

Marten Postma, P. V. van Haastert, 2016, Methods in molecular biology.

Regulation of Dictyostelium guanylyl cyclases.

P. V. van Haastert, Douwe M Veltman, 2003, Protist.

The cell density factor CMF regulates the chemoattractant receptor cAR1 in Dictyostelium

R. Gomer, P. V. van Haastert, J. D. Bishop, 1996, The Journal of cell biology.

Pleckstrin Homology Domain Diffusion in Dictyostelium Cytoplasm Studied Using Fluorescence Correlation Spectroscopy*

P. V. van Haastert, A. Visser, M. Hink, 2004, Journal of Biological Chemistry.

Chemotaxis in Dictyostelium discoideum: effect of concanavalin A on chemoattractant mediated cyclic gmp accumulation anlight scattering decrease.

P. V. van Haastert, T. M. Konijn, F. Krens, 1978, Cell Biology International Reports.

Unified control of chemotaxis and cAMP mediated cGMP accumulation by cAMP in Dictyostelium discoideum.

P. V. van Haastert, T. M. Konijn, F. Krens, 1977, Biochemical and biophysical research communications.

The modulation of cell surface cAMP receptors from Dictyostelium discoideum by ammonium sulfate.

P. V. van Haastert, 1985, Biochimica et Biophysica Acta.

Immunological detection of G-protein α-subunits in Dictyostelium discoideum

P. V. van Haastert, B. Snaar-Jagalska, P. V. Haastert, 1988 .

Signal transduction, chemotaxis, and cell aggregation in Dictyostelium discoideum cells without myosin heavy chain.

W. Loomis, J. Spudich, P. V. van Haastert, 1988, Developmental biology.

A Novel, Phospholipase C-independent Pathway of Inositol 1,4,5-Trisphosphate Formation in Dictyostelium and Rat Liver (*)

P. V. van Haastert, C. Erneux, A. Craxton, 1995, The Journal of Biological Chemistry.

Activation of soluble guanylyl cyclase at the leading edge during Dictyostelium chemotaxis.

P. V. van Haastert, J. Roelofs, A. Visser, 2004, Molecular biology of the cell.

Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase.

P. Devreotes, P. V. van Haastert, M. Postma, 2006, Molecular biology of the cell.

Intramolecular Activation Mechanism of the Dictyostelium LRRK2 Homolog Roco Protein GbpC*

P. V. van Haastert, A. Kortholt, Wouter N. van Egmond, 2008, Journal of Biological Chemistry.

Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase

A. Wittinghofer, P. V. van Haastert, M. Weyand, 2008, The EMBO journal.

A new set of small, extrachromosomal expression vectors for Dictyostelium discoideum.

P. V. van Haastert, Douwe M Veltman, Leonard Bosgraaf, 2009, Plasmid.

A model for cGMP signal transduction in Dictyostelium in perspective of 25 years of cGMP research

P. V. van Haastert, Leonard Bosgraaf, L. Bosgraaf, 2004, Journal of Muscle Research & Cell Motility.

Signal transduction in Dictyostelium fgd A mutants with a defective interaction between surface cAMP receptors and a GTP-binding regulatory protein [published erratum appears in J Cell Biol 1988 Dec;107(6 Pt 1):following 2463]

P. V. van Haastert, F. Kesbeke, B. Ewa Snaar-Jagalska, 1988, The Journal of cell biology.

Cyclic GMP binding activity in Dictyostelium discoideum

P. V. van Haastert, T. M. Konijn, J. Mato, 1978, FEBS letters.

The local cell curvature guides pseudopodia towards chemoattractants

P. V. van Haastert, L. Bosgraaf, 2009, HFSP Journal.

Aberrant cGMP-binding activity in non-chemotactic Dictyostelium discoideum mutants.

P. V. van Haastert, H. Kuwayama, G. T. Viel, 1995, Biochimica et biophysica acta.

Chemotaxis: A Feedback-Based Computational Model Robustly Predicts Multiple Aspects of Real Cell Behaviour

Matthew P. Neilson, J. Mackenzie, P. V. van Haastert, 2011, PLoS biology.

Forty-five years of cGMP research in Dictyostelium: understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis

P. V. van Haastert, Douwe M Veltman, Henderikus Pots, 2021, Molecular biology of the cell.

Immunological detection of G-protein α-subunits in Dictyostelium discoideum

P. V. van Haastert, F. Kesbeke, M. Pupillo, 1988 .

Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling

P. V. van Haastert, A. Kortholt, I. Keizer-Gunnink, 2007, The Journal of cell biology.

Multiple Regulatory Mechanisms for the Dictyostelium Roco Protein GbpC

P. V. van Haastert, A. Kortholt, Wouter N. van Egmond, 2011, The Journal of Biological Chemistry.