C. Kissinger

发表

Rapid automated molecular replacement by evolutionary search.

C R Kissinger, D K Gehlhaar, D B Fogel, 1999, Acta crystallographica. Section D, Biological crystallography.

Christopher J. Oldfield, K. W. Hipps, C. Brown, 2001, Journal of molecular graphics & modelling.

Electronic Reprint Biological Crystallography Structure of Hepatitis C Virus Ires Subdomain Iia Biological Crystallography Structure of Hepatitis C Virus Ires Subdomain Iia

P. A. Thompson, T. Hermann, C. Kissinger, 2022 .

Thousands of proteins likely to have long disordered regions.

A K Dunker, P. Romero, Z. Obradovic, 1998, Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing.

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine.

T. Hermann, C. Kissinger, Qiang Zhao, 2008, Bioorganic & medicinal chemistry letters.

Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex

Anna Tempczyk, Hans E. Parge, D. Knighton, 1995, Nature.

Structural analysis of a set of proteins resulting from a bacterial genomics project

B. Laubert, J. M. Sauder, K. Gajiwala, 2005, Proteins.

Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors.

Masaki Tomimoto, Charles Kissinger, Anthony M Giannetti, 2008, Bioorganic & medicinal chemistry letters.

Protein serine/threonine phosphatases.

C. Kissinger, J. E. Villafranca, H. Parge, 1996, Current opinion in biotechnology.

5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.

Matthew A. Lardy, C. Kissinger, Qiang Zhao, 2009, Bioorganic & medicinal chemistry letters.

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase.

P. A. Thompson, J. Khandurina, C. Kissinger, 2009, Bioorganic & medicinal chemistry letters.

Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.

Jingjing Zhao, Matthew A. Lardy, Frank Ruebsam, 2008, Bioorganic & medicinal chemistry letters.

Structure-based design of novel, urea-containing FKBP12 inhibitors.

D. Knighton, C. Kissinger, J. E. Villafranca, 1996, Journal of medicinal chemistry.

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents.

C. Kissinger, Qing Han, Michael Noble, 2008, Bioorganic & medicinal chemistry letters.

Refined crystal structure of ferredoxin II from Desulfovibrio gigas at 1.7 A.

C. Kissinger, L. Sieker, L. H. Jensen, 1991, Journal of molecular biology.

Structure of the 3 iron-4 sulfur cluster in Desulfovibrio gigas ferredoxin II

C. Kissinger, L. Sieker, L. H. Jensen, 1988 .

Structure-based design of novel calcineurin (PP2B) inhibitors

C. Kissinger, A. Tempczyk, J. E. Villafranca, 1997 .

Protein disorder and the evolution of molecular recognition: theory, predictions and observations.

A K Dunker, P. Romero, Z. Obradovic, 1998, Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing.

Identifying disordered regions in proteins from amino acid sequence

A.K. Dunker, Z. Obradovic, P. Romero, 1997, Proceedings of International Conference on Neural Networks (ICNN'97).

Structural studies of the engrailed homeodomain

G L Gilliland, N D Clarke, C. Pabo, 1994, Protein science : a publication of the Protein Society.

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

Carl O. Pabo, C. Pabo, T. Kornberg, 1990, Cell.

Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics.

P. Rejto, C. Kissinger, J. Meng, 2004, Journal of molecular biology.

J147 Reduces tPA-Induced Brain Hemorrhage in Acute Experimental Stroke in Rats

Guohong Li, C. Kissinger, J. E. Villafranca, 2022, Frontiers in Neurology.

Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.

C. Kissinger, Qiang Zhao, Yuefen Zhou, 2008, Bioorganic & medicinal chemistry letters.

4-(1,1-Dioxo-1,4-dihydro-1lambda6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase.

Matthew A. Lardy, C. Kissinger, Qing Han, 2008, Bioorganic & medicinal chemistry letters.

Interaction of a novel GDP exchange inhibitor with the Ras protein.

J. Brown, M. Snow, C. Kissinger, 1998, Biochemistry.

Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase.

Qiang Zhao, Helen McGuire, Alberto Gobbi, 2008, Bioorganic & medicinal chemistry letters.

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments.

C. Kissinger, Qiang Zhao, Yuefen Zhou, 2008, Bioorganic & medicinal chemistry letters.

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents.

T. Hermann, C. Kissinger, Qiang Zhao, 2008, Bioorganic & medicinal chemistry letters.

Building a Three-Dimensional Model of CYP2C9 Inhibition Using the Autocorrelator: An Autonomous Model Generator

Alberto Gobbi, Drew Bullard, Matthew A. Lardy, 2012, J. Chem. Inf. Model..

Ras oncoprotein inhibitors: the discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex.

L. Perkins, S. Liberles, J. Brown, 1997, Bioorganic & medicinal chemistry.

Crystallization and preliminary X-ray diffraction studies of the engrailed homeodomain and of an engrailed homeodomain/DNA complex.

C. Pabo, C. Kissinger, C O Pabo, 1990, Biochemical and biophysical research communications.

Design, synthesis and X-ray crystallographic studies of novel FKBP-12 ligands

C. Kissinger, R. Babine, J. E. Villafranca, 1995 .

Molecular replacement by evolutionary search.

Barry F. Smith, B A Smith, C R Kissinger, 2001, Acta crystallographica. Section D, Biological crystallography.

The crystal structure of the three‐iron ferredoxin II from Desulfovibrio gigas

C. Kissinger, L. Sieker, J. Legall, 1989, FEBS letters.

5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.

Matthew A. Lardy, C. Kissinger, Qiang Zhao, 2009, Bioorganic & medicinal chemistry letters.