K. Midha

发表

Molecular properties of WHO essential drugs and provisional biopharmaceutical classification.

G. Amidon, N. A. Kasim, M. Whitehouse, 2004, Molecular pharmaceutics.

Comparison of diltiazem bioavailability from 3 marketed extended-release products for once-daily administration: implications of chronopharmacokinetics and dynamics.

K. Midha, O. Eradiri, 1997, International journal of clinical pharmacology and therapeutics.

Analytical methods validation: Bioavailability, bioequivalence and pharmacokinetic studies

Thomas Layloff, Vinod P. Shah, Kamal K. Midha, 1992 .

Defining treatment refractoriness in schizophrenia.

R. Liberman, U. Malm, K. Midha, 1990, Schizophrenia bulletin.

The role of the lymphatic system in the presystemic absorption of fluphenazine after intramuscular administration of fluphenazine decanoate in rats

K. Midha, J. Hubbard, Y. Huang, 1995 .

The Roles of Depot Injection Sites and Proximal Lymph Nodes in the Presystemic Absorption of Fluphenazine Decanoate and Fluphenazine: Ex Vivo Experiments in Rats

K. Midha, J. Hubbard, Jiang-ping Luo, 1998, Pharmaceutical Research.

Clinical modulation of doxorubicin resistance by the calmodulin-inhibitor, trifluoperazine: a phase I/II trial.

G. T. Budd, K. Midha, R. Bukowski, 1988, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Simple and sensitive high-performance liquid chromatographic procedure with electrochemical detection for the determination of plasma concentrations of trimeprazine following single oral doses.

K. Midha, G. Mckay, J. Cooper, 1982, Journal of chromatography.

The metabolites of chlorpromazine N-oxide in rat bile.

K. Midha, J. Hubbard, G. Mckay, 1991, Xenobiotica; the fate of foreign compounds in biological systems.

Biowaiver monographs for immediate release solid oral dosage forms: furosemide.

D M Barends, H E Junginger, D. Barends, 2010, Journal of pharmaceutical sciences.

Biowaiver monographs for immediate release solid oral dosage forms: prednisolone.

D. Barends, H. Junginger, S. Stavchansky, 2007, Journal of pharmaceutical sciences.

Rediguieri CF, Porta V, Nunes DSG, Nunes TM, Junginger HE, Kopp S, Midha KK, Shah VP, Stavchansky S, Dressman JB, Barends DM. 2011. Biowaiver monographs for immediate‐release solid oral dosage forms: Metronidazole. J Pharm Sci 100:1618–1627.

D. Barends, H. Junginger, S. Stavchansky, 2011 .

The relative bioavailability of a commercial propranolol hydrochloride tablet in man.

K. Midha, T. Wilson, J. Cooper, 1982, Biopharmaceutics & drug disposition.

Metabolism and Disposition of Trimethadione in Pregnant Rats

H. Buttar, K. Midha, M. Rowe, 1979, Epilepsia.

N-oxygenation of clozapine by flavin-containing monooxygenase.

K. Midha, A. Rettie, G. Mckay, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Characterization of metabolites of clozapine N-oxide in the rat by micro-column high performance liquid chromatography/mass spectrometry with electrospray interface.

K. Midha, G. Lin, G. Mckay, 1996, Journal of pharmaceutical and biomedical analysis.

Sensitive method for the simultaneous measurement of fluphenazine decanoate and fluphenazine in plasma by high-performance liquid chromatography with coulometric detection.

K. Midha, J. Hubbard, J. P. Luo, 1997, Journal of chromatography. B, Biomedical sciences and applications.

Bioequivalence: Issues and Options

K. Midha, J. Hubbard, M. Rawson, 1997, Journal of Pharmacokinetics and Biopharmaceutics.

Individual and average bioequivalence of highly variable drugs and drug products.

K. Midha, J. Hubbard, M. Rawson, 1997, Journal of pharmaceutical sciences.

Correlation of fluphenazine plasma levels versus clinical response in patients: A pilot study

K. Midha, D. Keegan, G. Rauw, 1983, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

A gas chromatographic mass spectrometric assay for plasma trifluoperazine concentrations following single doses.

K. Midha, G. Mckay, H. U. Shetty, 1982, Biomedical mass spectrometry.

Chapter 13 Radioimmunoassays for Phenalkylamines

K. Midha, J. Hubbard, 1982 .

Extensive and enantioselective presystemic metabolism of dl-threo-methylphenidate in humans

K. Midha, J. Hubbard, N. Srinivas, 1991, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Enantioselective pharmacokinetics and pharmacodynamics of dl‐thero‐mcthylphenidate in children with attention deficit hyperactivity disorder

K. Midha, J. Hubbard, N. Srinivas, 1992, Clinical pharmacology and therapeutics.

Application of electrospray mass spectrometry in the identification of intact glucuronide and suplate conjugates of clozapine in rat.

K. Midha, J. Hubbard, G. Mckay, 1996, Xenobiotica; the fate of foreign compounds in biological systems.

The application of partial areas in assessment of rate and extent of absorption in bioequivalence studies of conventional release products: experimental evidence

K. Midha, J. Hubbard, M. Rawson, 1994 .

Enantiomeric drug development: issues, considerations, and regulatory requirements.

K. Midha, N. Srinivas, R. Barbhaiya, 2001, Journal of pharmaceutical sciences.

Binding of phenothiazine neuroleptics to plasma proteins.

K. Midha, R. Verbeeck, J. Cardinal, 1983, Biochemical pharmacology.

In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine

K. Midha, G. Mckay, Jiang-ping Luo, 2011, Biopharmaceutics & drug disposition.

Identification of clozapine N(+)-glucuronide in the urine of patients treated with clozapine using electrospray mass spectrometry.

K. Midha, G. Mckay, H. Luo, 1994, Biological mass spectrometry.

The impact of stereoisomerism in a bioequivalence study on two formulations of doxepin

K. Midha, J. Hubbard, M. Rawson, 1995 .

Logarithmic transformation in bioequivalence: application with two formulations of perphenazine.

K. Midha, J. Hubbard, G. Mckay, 1993, Journal of pharmaceutical sciences.

An improved synthesis of dideuterated thioridazine with the label in the piperidine ring

K. Midha, T. Mohammad, G. Mckay, 1990 .

METHOXYPHENAMINE AND DEXTROMETHORPHAN AS SAFE PROBES FOR DEBRISOQUINE HYDROXYLATION POLYMORPHISM

K. Midha, J. Hubbard, G. Mckay, 1984, The Lancet.

The impact of stereoisomerism in bioequivalence studies.

K. Midha, J. Hubbard, G. Mckay, 1998, Journal of pharmaceutical sciences.

Prolonged pharmacologic activity of neuroleptic drugs.

K. Midha, J. Hubbard, D. Ganes, 1987, Archives of general psychiatry.

Enantioselective aspects of the disposition of dl-threo-methylphenidate after the administration of a sustained-release formulation to children with attention deficit-hyperactivity disorder.

K. Midha, J. Hubbard, N. Srinivas, 1989, Journal of pharmaceutical sciences.

Identification of lactams as in vitro metabolites of piperidine-type phenothiazine antipsychotic drugs.

K. Midha, G. Lin, E. Hawes, 1996, Journal of pharmaceutical and biomedical analysis.

Phase I and II metabolites of benztropine in rat urine and bile.

K. Midha, G. Mckay, H. He, 1995, Xenobiotica; the fate of foreign compounds in biological systems.

Biosynthesis and characterization of glucuronide metabolites of fluphenazine: 7-hydroxyfluphenazine glucuronide and fluphenazine glucuronide.

K. Midha, J. Hubbard, C. Jackson, 1991, Xenobiotica; the fate of foreign compounds in biological systems.

Methylphenidate blood levels and therapeutic response in children with attention-deficit hyperactivity disorder: I. Effects of different dosing regimens.

Martin H. Teicher, K. Midha, A. Polcari, 2006, Journal of child and adolescent psychopharmacology.

Radioimmunoassay for fluphenazine in human plasma.

K. Midha, J. Hubbard, J. Cooper, 1980, Communications in psychopharmacology.

Effects of Food on the Pharmacokinetics of Methylphenidate

K. Midha, J. Hubbard, G. Mckay, 2001, Pharmaceutical Research.

Use of Parent Drug and Metabolite Data in Bioavailability Assessment of a Novel Diltiazem HC1 Once-Daily Product

K. Midha, O. Eradiri, 1995, Pharmaceutical Research.

The roles of stereochemistry and partial areas in a parallel design study to assess the bioequivalence of two formulations of hydroxychloroquine: A drug with a very long half life

K. Midha, J. Hubbard, G. Mckay, 1996 .

In vitro characterization of the metabolism of haloperidol using recombinant cytochrome p450 enzymes and human liver microsomes.

K. Midha, G. Mckay, J. Song, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Metabolism of piperidine-type phenothiazine antipsychotic agents. IV. Thioridazine in dog, man and rat.

K. Midha, G. Lin, G. Mckay, 1993, Xenobiotica; the fate of foreign compounds in biological systems.

N(+)-glucuronidation of aliphatic tertiary amines, a general phenomenon in the metabolism of H1-antihistamines in humans.

K. Midha, G. Mckay, E. Hawes, 1991, Xenobiotica; the fate of foreign compounds in biological systems.

Stereoselective disposition of methylphenidate in children with attention-deficit disorder.

K. Midha, J. Hubbard, N. Srinivas, 1987, The Journal of pharmacology and experimental therapeutics.

Bioequivalence; Its History, Practice, and Future

K. Midha, G. Mckay, 2009, The AAPS Journal.

Bio-International ’94 Conference on Bioavailability, Bioequivalence and Pharmacokinetic Studiesand Pre-Conference Satellite on ‘in vivo/in vitro correlation’

K. Midha, I. McGilveray, H. Blume, 1995, European Journal of Drug Metabolism and Pharmacokinetics.

Gas chromatographic and mass spectrometric analysis of the products of methylation of sulfonylurea drugs.

K. Midha, I. McGilveray, D. Awang, 1976, Biomedical mass spectrometry.

Evaluation of Orally Administered Highly Variable Drugs and Drug Formulations

Mario A. González, W. H. Barr, L. Benet, 1996, Pharmaceutical Research.

Bioequivalence of two thorazine tablet formulations using radioimmunoassay and gas chromatographic-mass spectrometric methods.

K. Midha, J. Hubbard, G. Mckay, 1990, Journal of pharmaceutical sciences.

Comparative bioavailability of two tablet formulations of fluphenazine dihydrochloride in drug-free psychiatric patients.

K. Midha, J. Hubbard, G. Mckay, 1990, Journal of pharmaceutical sciences.

Single dose kinetics of thioridazine and its two psychoactive metabolites in healthy humans: a dose proportionality study.

K. Midha, J. Hubbard, G. Mckay, 1989, Journal of pharmaceutical sciences.

Comparative bioavailability of a new commercial tablet formulation and two lots of a reference formulation of haloperidol.

K. Midha, J. Hubbard, G. Mckay, 1989, Journal of pharmaceutical sciences.

Radioimmunoassay for fluphenazine sulfoxide in human plasma.

K. Midha, J. Hubbard, G. Mckay, 1988, Journal of pharmacological methods.

Radioimmunoassay for trimeprazine in human plasma.

K. Midha, G. Mckay, G. Rauw, 1984, Journal of pharmacological methods.

Subnanogram quantitation of chlorpheniramine in plasma by a new radioimmunoassay and comparison with a liquid chromatographic method.

K. Midha, G. Mckay, G. Rauw, 1984, Journal of pharmaceutical sciences.

Development of radioimmunoassays for trifluoperazine and their application to metabolic studies of the drug.

K. Midha, G. Mckay, G. Rauw, 1983, Journal of pharmacological methods.

N(+)-glucuronidation of aliphatic tertiary amines in human: antidepressant versus antipsychotic drugs.

K. Midha, G. Mckay, E. Hawes, 1995, Xenobiotica; the fate of foreign compounds in biological systems.

Analytical methods validation: Bioavailability, bioequivalence and pharmacokinetic studies

A Yacobi, C. T. Viswanathan, C T Viswanathan, 1991, European Journal of Drug Metabolism and Pharmacokinetics.

High-performance liquid chromatographic assay for nanogram determination of chlorpromazine and its comparison with a radioimmunoassay.

K. Midha, J. Hubbard, I. McGilveray, 1981, Journal of pharmaceutical sciences.

Biowaiver monographs for immediate release solid oral dosage forms based on biopharmaceutics classification system (BCS) literature data: chloroquine phosphate, chloroquine sulfate, and chloroquine hydrochloride.

D. Barends, H. Junginger, K. Midha, 2005, Journal of pharmaceutical sciences.

Fluphenazine, trifluoperazine and perphenazine in Vacutainers.

K. Midha, J. Hubbard, Y. Lapierre, 1981, Canadian Medical Association journal.

Kinetics of oral fluphenazine disposition in humans by GC-MS

K. Midha, G. Mckay, R. Edom, 2004, European Journal of Clinical Pharmacology.

Piperazine ring cleavage in the electron impact induced fragmentation of piperazine type phenothiazine antipsychotic agents

K. Midha, H. U. Shetty, E. Hawes, 1983 .

Bioanalytical Method Validation—A Revisit with a Decade of Progress

Vinod P. Shah, Kamal K. Midha, John W. A. Findlay, 2000, Pharmaceutical Research.

Detection of Nanogram Levels of Various Ring-Substituted Phenylisopropylamines in Urine and Plasma by GLC-ECD

K. Midha, J. Cooper, D. Gagné, 1979 .

Synthesis of the piperidinone metabolites of piperidine type phenothiazine antipsychotic drugs via ruthenium tetroxide oxidation

K. Midha, G. Lin, E. Hawes, 1991 .

Biowaiver monographs for immediate release solid oral dosage forms: ibuprofen.

D. Barends, H. Junginger, K. Midha, 2005, Journal of pharmaceutical sciences.

Synthesis of the N-oxides of phenothiazine antipsychotic agents.

K. Midha, J. Hubbard, G. Lin, 1993, Journal of pharmaceutical sciences.

Isothermal capillary gas chromatography with electron-capture detection of heptafluorobutyryl-L-prolyl derivatives of chiral amphetamines.

K. Midha, J. Hubbard, N. Srinivas, 1989, Journal of chromatography.

Analytical Methods Validation: Bioavailability, Bioequivalence and Pharmacokinetic Studies

Thomas Layloff, Vinod P. Shah, Kamal K. Midha, 1992, Pharmaceutical Research.

Dehalogenation reactions in the fast atom bombardment mass spectrometry of phenothiazine‐related drugs

K. Midha, J. Hubbard, G. Mckay, 1991 .

Biowaiver monographs for immediate release solid oral dosage forms: levofloxacin.

D. Barends, H. Junginger, S. Stavchansky, 2011, Journal of pharmaceutical sciences.

Synthesis of deuterium labelled thioridazine via ruthenium tetroxide oxidation of the piperidine ring

K. Midha, T. Mohammad, E. Hawes, 1988 .

Synthesis and Properties of Haptens for the Development of Radioimmunoassays for Thioridazine, Mesoridazine, and Sulforidazine

K. Midha, B. Chakraborty, E. Hawes, 1987, Pharmaceutical Research.

Synthesis of deuterium labelled analogues of S‐oxidative metabolites of thioridazine

K. Midha, T. Mohammad, E. Hawes, 1989 .

The sulfoxidation of fluphenazine in schizophrenic patients maintained on fluphenazine decanoate

S. Marder, K. Midha, T. Putten, 2004, Psychopharmacology.

Pharmacokinetics of Fenfluramine and Neuroleptics in the Treatment of Refractory Schizophrenia

R. Liberman, K. Midha, J. Hubbard, 1992 .

The metabolism of chlorpromazine N-oxide in the rat.

K. Midha, G. Mckay, E. Hawes, 1988, Xenobiotica; the fate of foreign compounds in biological systems.

Stereoselective pharmacokinetics of doxepin isomers

K. Midha, J. Hubbard, G. Mckay, 2004, European Journal of Clinical Pharmacology.

Development of a sensitive and specific radioimmunoassay for benztropine.

K. Midha, G. Mckay, H. He, 1993, Journal of pharmaceutical sciences.

Determination of Phenothiazines: The Present-Day Scene

K. Midha, G. Mckay, S. Cooper, 1986 .

Decomposition of sulphoxide metabolites of phenothiazine antipsychotics during gas chromatographic analysis

K. Midha, K. Hall, P. Yeung, 1982 .

GLC-mass spectrometric procedure with selected-ion monitoring for determination of plasma concentrations of unlabeled and labeled barbital following simultaneous oral and intravenous administration.

K. Midha, F. Varin, P. Larochelle, 1980, Journal of pharmaceutical sciences.

Application of GLC-AFID and GLC-MS procedures to analysis of plasma in suspected cases of psychotropic drug overdose.

K. Midha, I. McGilveray, D. Webb, 1981, Clinical toxicology.

Determination of risperidone in plasma by high-performance liquid chromatography with electrochemical detection: application to therapeutic drug monitoring in schizophrenic patients.

S. Marder, K. Midha, M. Aravagiri, 1993, Journal of pharmaceutical sciences.

Determination of therapeutic levels of metronidazole in plasma by gas-liquid chromatography.

K. Midha, I. McGilveray, J. Cooper, 1973, Journal of chromatography.

Consensus report from "Bio International '89": issues in the evaluation of bioavailability data.

K. Midha, I. McGilveray, S. Dighe, 1990, Journal of pharmaceutical sciences.

Conference report: Bio-International 2005.

K. Midha, V. Shah, R. Patnaik, 2007, Journal of pharmaceutical sciences.

Biowaiver monographs for immediate release solid oral dosage forms: acetazolamide.

D. Barends, H. Junginger, S. Stavchansky, 2008, Journal of pharmaceutical sciences.

Biowaiver monographs for immediate release solid oral dosage forms: isoniazid.

D. Barends, G. Amidon, H. Junginger, 2007, Journal of pharmaceutical sciences.

Biowaiver monographs for immediate release solid oral dosage forms: diclofenac sodium and diclofenac potassium.

D. Barends, J. Polli, G. Amidon, 2009, Journal of pharmaceutical sciences.

Biowaiver monographs for immediate release solid oral dosage forms: aciclovir.

D. Barends, G. Amidon, M. Bermejo, 2008, Journal of pharmaceutical sciences.

Biowaiver monographs for immediate release solid oral dosage forms: ciprofloxacin hydrochloride.

D. Barends, H. Junginger, S. Stavchansky, 2011, Journal of pharmaceutical sciences.

The metabolism of 3-methoxyamphetamine in dog, monkey and man.

K. Midha, J. Hubbard, J. Cooper, 1981, Xenobiotica; the fate of foreign compounds in biological systems.

High performance liquid chromatographic and mass spectrometric identification of dimethylxanthine metabolites of caffeine in human plasma.

K. Midha, S. Sved, R. D. Hossie, 1977, Biomedical mass spectrometry.

Biowaiver monographs for immediate release solid oral dosage forms based on biopharmaceutics classification system (BCS) literature data: verapamil hydrochloride, propranolol hydrochloride, and atenolol.

G L Amidon, D M Barends, M Olling, 2004, Journal of pharmaceutical sciences.

Biowaiver monographs for immediate release solid oral dosage forms: quinidine sulfate.

D. Barends, H. Junginger, S. Stavchansky, 2009, Journal of pharmaceutical sciences.

Pharmaceutical sciences in 2020

Daan Crommelin, K. Midha, H. Leufkens, 2010, Nature Reviews Drug Discovery.

Biowaiver monographs for immediate release solid oral dosage forms: acetaminophen (paracetamol).

D. Barends, G. Amidon, H. Junginger, 2006, Journal of pharmaceutical sciences.

Decomposition of clozapine N-oxide in the qualitative and quantitative analysis of clozapine and its metabolites.

K. Midha, J. Hubbard, G. Lin, 1994, Journal of pharmaceutical sciences.

Identification of a quaternary ammonium-linked glucuronide of chlorpromazine in the urine of a schizophrenic patient treated with chlorpromazine.

K. Midha, A. Chaudhary, J. Hubbard, 1988, Drug metabolism and disposition: the biological fate of chemicals.

Biowaiver monographs for immediate release solid oral dosage forms: metronidazole.

D. Barends, H. Junginger, S. Stavchansky, 2011, Journal of pharmaceutical sciences.

The bioavailability of commercial metronidazole formulations.

K. Midha, J. Loo, I. McGilveray, 1978, International journal of clinical pharmacology and biopharmacy.

A placebo-controlled trial of fluoxetine added to neuroleptic in patients with schizophrenia

D. Goff, K. Midha, J. Hubbard, 1995, Psychopharmacology.

In vivo metabolism of N-oxides

K. Midha, J. Hubbard, G. Mckay, 1991 .

Biowaiver monographs for immediate release solid oral dosage forms: lamivudine.

D. Barends, H. Junginger, S. Stavchansky, 2011, Journal of pharmaceutical sciences.

Stereospecific radioimmunoassays for l-ephedrine and d-ephedrine in human plasma.

K. Midha, J. Hubbard, J. Cooper, 1983, Journal of pharmaceutical sciences.

Simple and specific electron-capture GLC assay for plasma and urine ephedrine concentrations following single doses.

K. Midha, I. McGilveray, J. Cooper, 1979, Journal of pharmaceutical sciences.

The metabolism of chlorpromazine N-oxide in man and dog.

K. Midha, G. Mckay, E. Hawes, 1990, Xenobiotica; the fate of foreign compounds in biological systems.

Therapeutic monitoring of chlorpromazine. III: Minimal interconversion between chlorpromazine and metabolites in human blood.

K. Midha, J. Hubbard, G. Mckay, 1986, Therapeutic drug monitoring.

Therapeutic monitoring of chlorpromazine I: Pitfalls in plasma analysis.

D. Jenden, K. Midha, J. Hubbard, 1985, Therapeutic drug monitoring.

Therapeutic monitoring of chlorpromazine II: Pitfalls in whole blood analysis.

K. Midha, J. Hubbard, G. Mckay, 1985, Therapeutic drug monitoring.

Synthesis and properties of some hypotensive N-alkylaminopropionic esters and N,N-dialkylaminopropionic esters and their hydroxamic acids.

K. Midha, J. Hubbard, R. T. Coutts, 1971, Journal of pharmaceutical sciences.

2-methyl-3-(4-phenylpiperidino)propionohydroxamic acid hydrochloride--a new hypotensive agent.

K. Midha, J. Hubbard, R. T. Coutts, 1970, European journal of pharmacology.

Biowaiver monographs for immediate release solid oral dosage forms: pyrazinamide.

D. Barends, G. Amidon, H. Junginger, 2008, Journal of pharmaceutical sciences.

Biowaiver monographs for immediate release solid oral dosage forms: rifampicin.

D. Barends, H. Junginger, S. Stavchansky, 2009, Journal of pharmaceutical sciences.

A pharmacokinetic study of trifluoperazine in two ethnic populations

K. Midha, J. Hubbard, G. Mckay, 2004, Psychopharmacology.

Relative bioavailability of a commercial trifluoperazine tablet formulation using a radioimmunoassay technique.

K. Midha, G. Mckay, J. Cooper, 1984, Journal of pharmaceutical sciences.

Monitoring of Therapeutic Concentrations of Psychotropic Drugs in Plasma by Radioimmunoassays

K. Midha, J. Hubbard, J. Loo, 1978 .

Fluphenazine plasma levels in patients receiving low and conventional doses of fluphenazine decanoate

S. Marder, J. Mintz, K. Midha, 1986, Psychopharmacology.

Pharmacokinetics of long-acting injectable neuroleptic drugs: clinical implications

S. Marder, K. Midha, T. Putten, 2004, Psychopharmacology.

Simultaneous measurement of fluphenazine and [2H4]fluphenazine in plasma using solids probe tandem mass spectrometry

K. Midha, G. Mckay, R. Edom, 1995 .

Subnanogram determination of fluphenazine in human plasma by gas chromatography mass spectrometry.

K. Midha, G. Mckay, R. Edom, 1983, Biomedical mass spectrometry.

In vitro hydrolysis of RR,SS-threo-methylphenidate by blood esterases--differential and enantioselective interspecies variability.

K. Midha, J. Hubbard, G. Mckay, 1991, Chirality.

Development of enantioselective gas chromatographic quantitation assay for dl-threo-methylphenidate in biological fluids.

K. Midha, J. Hubbard, H. Lim, 1986, Journal of chromatography.

Transesterification using hydrogen bromide in diethyl ether--a means of identifying components of mixtures of fatty esters.

K. Midha, R. T. Coutts, 1969, Journal of pharmaceutical sciences.

Radioimmunoassay for psychotropic drugs II: synthesis and properties of haptens for tricyclic antidepressants.

K. Midha, J. Hubbard, J. Cooper, 1978, Journal of pharmaceutical sciences.

Simultaneous determination of procainamide and N-acetylprocainamide in plasma by high-performance liquid chromatography.

K. Midha, J. Cooper, A. G. Butterfield, 1978, Journal of pharmaceutical sciences.

GLC determination of quinidine from plasma and whole blood.

K. Midha, C. Charette, 1974, Journal of pharmaceutical sciences.

Bio-International ’92, Conference on Bioavailability, Bioequivalence and Pharmacokinetic Studies

K. Midha, H. Blume, 1993 .

Biowaiver monographs for immediate release solid oral dosage forms: ranitidine hydrochloride.

D M Barends, H E Junginger, D. Barends, 2005, Journal of pharmaceutical sciences.

Bio-International 92, Conference on Bioavailability, Bioequivalence, and Pharmacokinetic Studies

K. Midha, H. Blume, 1993 .

Biowaiver monographs for immediate release solid oral dosage forms: ethambutol dihydrochloride.

D. Barends, G. Amidon, H. Junginger, 2008, Journal of pharmaceutical sciences.

Bioavailability of 11 quinidine formulations adn pharmacokinetic variation in humans.

K. Midha, I. McGilveray, M. Rowe, 1981, Journal of pharmaceutical sciences.

The Role of Metabolites in Bioequivalence

K. Midha, J. Hubbard, M. Rawson, 2004, Pharmaceutical Research.

Effect of cesium on the properties of cardiac muscle.

K. Midha, K. Prasad, 1973, Japanese Heart Journal.

Identification of urinary catechol and methylated catechol metabolites of phenytoin in humans, monkeys, and dogs by GLC and GLC-mass spectrometry.

K. Midha, I. McGilveray, K. Hindmarsh, 1977, Journal of pharmaceutical sciences.

Quinidine inhibits the 7-hydroxylation of chlorpromazine in extensive metabolisers of debrisoquine

K. Midha, J. Cooper, E. Hawes, 1996, European Journal of Clinical Pharmacology.

The metabolism of piperidine-type phenothiazine antipsychotic agents. II. Sulforidazine in dog and human.

K. Midha, G. Lin, G. Mckay, 1993, Xenobiotica; the fate of foreign compounds in biological systems.

The identification of two new urinary metabolites of fenfluramine in man.

K. Midha, J. Hubbard, I. McGilveray, 1983, Xenobiotica; the fate of foreign compounds in biological systems.

GLC Determination of Plasma Concentrations of γ-OxO Metabolite of Phenylbutazone

K. Midha, I. McGilveray, J. Cooper, 1978 .

GLC determination of plasma concentration of phenylbutazone and its metabolite oxyphenbutazone.

K. Midha, I. McGilveray, C. Charette, 1974, Journal of pharmaceutical sciences.

The assay of phenylbutazone in human plasma by a specific and sensitive gas-liquid chromatographic procedure.

K. Midha, I. McGilveray, R. Brien, 1974, Journal of chromatography.

Identification and estimation of phenytoin and its major metabolite in rat brain following its administration by gas-liquid chromatography and gas-liquid chromatography-mass spectrometry.

H. Buttar, K. Midha, C. Charette, 1978, Journal of chromatography.

Sensitive GLC procedure simultaneous determination of phenytoin and its major metabolite from plasma following single doses of phenytoin.

D. L. Wilson, K. Midha, I. McGilveray, 1976, Journal of pharmaceutical sciences.

GLC determination of plasma levels of warfarin.

K. Midha, I. McGilveray, J. Cooper, 1974, Journal of Pharmacy and Science.

GLC determination of plasma acenocoumarol levels.

K. Midha, J. Cooper, 1977, Journal of pharmaceutical sciences.

GLC determination of plasma concentrations of phenprocoumon.

K. Midha, J. Hubbard, I. McGilveray, 1976, Journal of pharmaceutical sciences.

High-performance liquid chromatographic assay of indomethacin and its application in pharmacokinetics in healthy volunteers.

K. Midha, G. Mckay, J. Cooper, 1982, Journal of chromatography.

An open trial of buspirone added to neuroleptics in schizophrenic patients.

D. Goff, K. Midha, A. Brotman, 1991, Journal of clinical psychopharmacology.

Selective in vivo inhibition by quinidine of methoxyphenamine oxidation in rat models of human debrisoquine polymorphism.

K. Midha, G. Mckay, T. Inaba, 1989, Xenobiotica; the fate of foreign compounds in biological systems.

Metabolism of methoxyphenamine in extensive and poor metabolizers of debrisoquin

G McKay, K. Midha, G. Mckay, 1985, Clinical pharmacology and therapeutics.

Quinine is a more potent inhibitor than quinidine in rat of the oxidative metabolic routes of methoxyphenamine which involve debrisoquine 4-hydroxylase.

K. Midha, G. Mckay, E. Hawes, 1991, Xenobiotica; the fate of foreign compounds in biological systems.

Influence of urinary pH on the disposition of methoxyphenamine and three metabolites in humans.

K. Midha, E. Hawes, S. D. Roy, 1987, Journal of pharmaceutical sciences.

Methoxyphenamine O-demethylase and 5-hydroxylase: a GLC-ECD assay to study their activities and their inhibition by debrisoquine and sparteine.

K. Midha, G. Mckay, E. Hawes, 1987, Pharmacology & therapeutics.

Methoxyphenamine metabolism in rat models of human debrisoquine phenotypes.

K. Midha, J. Hubbard, G. Mckay, 1985, Canadian journal of physiology and pharmacology.

Identification of new secondary metabolites of methoxyphenamine in man.

K. Midha, G. Mckay, J. Cooper, 1983, Xenobiotica; the fate of foreign compounds in biological systems.

Metabolism of methoxyphenamine in man and in monkey.

K. Midha, I. McGilveray, R. Dawe, 1976, Drug metabolism and disposition: the biological fate of chemicals.

Effect of quinidine on the interconversion kinetics between haloperidol and reduced haloperidol in humans: implications for the involvement of cytochrome P450IID6

K. Midha, J. Hubbard, D. Young, 2004, European Journal of Clinical Pharmacology.

Gas chromatographic quantitation of methoxyphenamine and three of its metabolites in plasma.

K. Midha, G. Mckay, E. Hawes, 1984, Journal of chromatography.

Enantioselective gas chromatographic assays with electron-capture detection for methoxyphenamine and its three primary metabolites in human urine.

K. Midha, J. Hubbard, G. Mckay, 1989, Journal of Chromatography A.

Identification of phenolic acids in human urine by ion monitoring.

K. Midha, J. Hubbard, J. Cooper, 1982, Xenobiotica; the fate of foreign compounds in biological systems.

Analysis of perfluoroacyl derivatives of ephedrine, pseudoephedrine and analogues by gas chromatography and mass spectrometry

K. Midha, R. T. Coutts, G. Jones, 1980 .

Human metabolism of methoxyphenamine.

K. Midha, R. T. Coutts, B. Chundela, 1977, Journal of chromatography.

alpha-Methyldopamine, a key intermediate in the metabolic disposition of 3,4-methylenedioxyamphetamine in vivo in dog and monkey.

K. Midha, J. Hubbard, J. Cooper, 1978, Drug metabolism and disposition: the biological fate of chemicals.

Absolute bioavailability and stereoselective pharmacokinetics of doxepin

K. Midha, J. Hubbard, G. Mckay, 2002, Xenobiotica; the fate of foreign compounds in biological systems.

Stereoselective in vivo and in vitro studies on the metabolism of doxepin and N-desmethyldoxepin.

K. Midha, J. Hubbard, G. Mckay, 1997, Xenobiotica; the fate of foreign compounds in biological systems.

Chiral pharmacology and its consequences for therapeutic monitoring.

K. Midha, J. Hubbard, H. Lim, 1986, Clinical biochemistry.

An ultrasensitive method for the measurement of haloperidol and reduced haloperidol in plasma by high-performance liquid chromatography with coulometric detection.

K. Midha, J. Hubbard, G. Mckay, 1988, Therapeutic drug monitoring.

Interconversion between haloperidol and reduced haloperidol in humans.

K. Midha, J. Hubbard, G. Mckay, 1987, Journal of clinical psychopharmacology.

Identification of 3-O-methyl-alpha-methyldopamine as a urinary metabolite of 3,4-methylenedioxyamphetamine in dog and monkey.

K. Midha, J. Cooper, A. By, 1977, Drug metabolism and disposition: the biological fate of chemicals.

Metabolic O-demethylation of 3,4-dimethoxyamphetamine in vivo in dog and monkey.

K. Midha, J. Hubbard, J. Cooper, 1979, Xenobiotica; the fate of foreign compounds in biological systems.

The metabolism of p-methoxyamphetamine in dog and monkey. O-demethylation as a major route.

K. Midha, J. Hubbard, J. Cooper, 1977, Drug metabolism and disposition: the biological fate of chemicals.

The elucidation of the mass spectral fragmentation pathway of α‐methyldopamine derivatives by chlorine labeling

K. Midha, J. Hubbard, J. Cooper, 1979 .

GLC determination of plasma levels of intact chlorpropamide or tolbutamide.

K. Midha, I. McGilveray, C. Charette, 1976, Journal of pharmaceutical sciences.

Synthesis and characterization of quaternary ammonium-linked glucuronide metabolites of drugs with an aliphatic tertiary amine group.

K. Midha, G. Mckay, E. Hawes, 1992, Journal of pharmaceutical sciences.

The quaternary ammonium-linked glucuronide of doxepin: a major metabolite in depressed patients treated with doxepin.

K. Midha, G. Mckay, E. Hawes, 1991, Drug metabolism and disposition: the biological fate of chemicals.

Clinical Perspectives of Some Neuroleptics Through Development and Application of Their Assays

S. Marder, K. Midha, T. Putten, 1993, Therapeutic Drug Monitoring.

Plasma Levels of Fluphenazine in Patients Receiving Fluphenazine Decanoate Relationship to Clinical Response

S. Marder, J. Mintz, K. Midha, 1991, British Journal of Psychiatry.

Fluphenazine plasma levels and clinical response.

S. Marder, J. Mintz, K. Midha, 1990, Psychopharmacology bulletin.

Radioimmunoassay and other methods for trace analysis of N-oxide compounds

S. Marder, K. Midha, J. Hubbard, 1991 .

At Issue: Defining Treatment Refractoriness in Schizophrenia

R. Liberman, U. Malm, K. Midha, 1990 .

Impact of clinical pharmacokinetics on neuroleptic therapy in patients with schizophrenia.

S. Marder, K. Midha, J. Hubbard, 1994, Journal of psychiatry & neuroscience : JPN.

Pharmacokinetics of fluphenazine, a highly lipophilic drug, estimated from a pulse dose of a stable isotopomer in dogs at steady state.

K. Midha, J. Hubbard, G. Mckay, 1999, Journal of pharmaceutical sciences.

Metabolism of Phenothiazine and Butyrophenone Antipsychotic Drugs

S. Marder, K. Midha, J. Hubbard, 1993, British Journal of Psychiatry.

The metabolism of piperidine-type phenothiazine antipsychotic agents. I. Sulforidazine in the rat.

G McKay, K. Midha, G. Lin, 1992, Xenobiotica; the fate of foreign compounds in biological systems.

Therapeutic Monitoring of Steady‐State Plasma Levels of the N4'‐Oxide Metabolite of Fluphenazine in Chronically Treated Schizophrenic Patients Determined by a Specific and Sensitive Radioimmunoassay

S. Marder, K. Midha, J. Hubbard, 1990, Therapeutic drug monitoring.

Development and application of a radioimmunoassay for fluphenazine based on monoclonal antibodies and its comparison with alternate assay methods.

K. Midha, T. Steeves, G. Mckay, 1990, Journal of pharmaceutical sciences.

Therapeutic Monitoring of Chlorpromazine IV: Comparison of a New High‐Performance Liquid Chromatographic Method with Radioimmunoassays for Parent Drug and Some of Its Major Metabolites

K. Midha, J. Hubbard, G. Mckay, 1987, Therapeutic drug monitoring.

Development and application of a specific radioimmunoassay for trifluoperazine N4'-oxide to a kinetic study in humans.

K. Midha, M. Aravagiri, E. Hawes, 1986, The Journal of pharmacology and experimental therapeutics.

Radioimmunoassay for the sulfoxide metabolite of trifluoperazine and its application to a kinetic study in humans.

K. Midha, M. Aravagiri, E. Hawes, 1984, Journal of pharmaceutical sciences.

The metabolism of piperidine-type phenothiazine antipsychotic agents. III. Mesoridazine in dog, human and rat.

K. Midha, G. Lin, G. Mckay, 1993, Xenobiotica; the fate of foreign compounds in biological systems.

Stepwise determination of multicompartment disposition and absorption parameters from extravascular concentration-time data. Application to mesoridazine, flurbiprofen, flunarizine, labetalol, and diazepam

Kamal K. Midha, J. Chris Sackellares, John G. Wagner, 1991, Journal of Pharmacokinetics and Biopharmaceutics.

Evaluation of the Bioequivalence of Highly-Variable Drugs and Drug Products

Laszlo Endrenyi, Kamal K. Midha, Laszlo Tothfalusi, 2001, Pharmaceutical Research.

Scaling or wider bioequivalence limits for highly variable drugs and for the special case of C(max).

K. Midha, L. Endrenyi, L. Tothfalusi, 2003, International journal of clinical pharmacology and therapeutics.

Radioimmunoassay for psychotropic drugs I: synthesis and properties of haptens for chlorpromazine.

K. Midha, J. Hubbard, I. McGilveray, 1978, Journal of pharmaceutical sciences.

Radioimmunoassay for chlorpromazine in plasma.

K. Midha, J. Hubbard, J. Loo, 1979, Clinical chemistry.

Subnanogram quantitation of chlorpromazine in plasma by high-performance liquid chromatography with electrochemical detection.

K. Midha, G. Mckay, J. Cooper, 1983, Journal of pharmaceutical sciences.

An Ultrasensitive Method for the Measurement of Fluphenazine in Plasma by High‐Performance Liquid Chromatography with Coulometric Detection

K. Midha, J. Hubbard, G. Mckay, 1989, Therapeutic Drug Monitoring.

Radioimmunoassay for psychotropic drugs. III: Synthesis and properties of haptens for trifluoperazine and fluphenazine.

K. Midha, G. Mckay, G. Rauw, 1984, Journal of Pharmacy and Science.

Biowaiver monographs for immediate release solid oral dosage forms: metoclopramide hydrochloride.

D. Barends, H. Junginger, S. Stavchansky, 2008, Journal of pharmaceutical sciences.

Radioimmunoassay for trifluoperazine in human plasma.

K. Midha, J. Hubbard, J. Cooper, 1981, British journal of clinical pharmacology.

Radioimmunoassay for perphenazine in human plasma.

K. Midha, J. Hubbard, J. Cooper, 1981, British journal of clinical pharmacology.

Separation of enantiomers of derivatised or underivatised propranolol by means of high-performance liquid chromatography.

K. Midha, J. Hubbard, M. B. Gupta, 1988, Journal of chromatography.

RADIOIMMUNOASSAY FOR PSYCHOTROPIC DRUGS. I. SYNTHESIS AND PROPERTIES OF HAPTENS FOR CHLORPROMAZINE

K. Midha, J. Hubbard, I. McGilveray, 1979 .

Cis-flupentixol metabolites in rat plasma and bile. The first proof of glutathione conjugation at the exocyclic double bond.

K. Midha, J. Hubbard, G. Mckay, 1991, Drug metabolism and disposition: the biological fate of chemicals.

Radioimmunoassay for the 7-hydroxy metabolite of trifluoperazine and its application to a kinetic study in human volunteers.

K. Midha, M. Aravagiri, E. Hawes, 1985, Journal of pharmaceutical sciences.

A GLC-nitrogen phosphorous detector assay for trifluoperazine in plasma.

K. Midha, J. Cooper, E. Hawes, 1982, Journal of pharmaceutical sciences.

Synthesis of deuterium labelled trifluoperazine

K. Midha, E. Hawes, H. Shetty, 1981 .

Studies on the Mechanism of Absorption of Depot Neuroleptics: Fluphenazine Decanoate in Sesame oil

K. Midha, J. Hubbard, Jiang-ping Luo, 1997, Pharmaceutical Research.

The role of metabolites in a bioequivalence study II: amoxapine, 7-hydroxyamoxapine, and 8-hydroxyamoxapine.

K. Midha, J. Hubbard, G. Mckay, 1999, International journal of clinical pharmacology and therapeutics.

Biowaiver monographs for immediate release solid oral dosage forms: prednisone.

D. Barends, H. Junginger, S. Stavchansky, 2007, Journal of pharmaceutical sciences.

Evidence that dogs do not model enantioselective pharmacokinetics of dl-methylphenidate in humans.

K. Midha, J. Hubbard, N. Srinivas, 1991, Journal of pharmaceutical sciences.

Characterization of the human hepatic cytochromes P450 involved in the in vitro oxidation of clozapine.

K. Midha, M. Eichelbaum, G. Mckay, 1999, Chemico-biological interactions.

Development and application of a specific and sensitive radioimmunoassay for trihexyphenidyl to a pharmacokinetic study in humans.

K. Midha, G. Mckay, H. He, 1995, Journal of pharmaceutical sciences.

An Approach for Widening the Bioequivalence Acceptance Limits in the Case of Highly Variable Drugs

K. Midha, R. Kringle, F. Snikeris, 1995, Pharmaceutical Research.

Enantioselective Pharmacokinetics of dl-threo-Methylphenidate in Humans

K. Midha, J. Hubbard, N. Srinivas, 2004, Pharmaceutical Research.

Biowaiver monographs for immediate release solid oral dosage forms: mefloquine hydrochloride.

D. Barends, H. Junginger, S. Stavchansky, 2011, Journal of pharmaceutical sciences.

Biowaiver monographs for immediate release solid oral dosage forms: cimetidine.

D. Barends, G. Amidon, H. Junginger, 2006, Journal of pharmaceutical sciences.

Challenges and opportunities in establishing scientific and regulatory standards for assuring therapeutic equivalence of modified-release products: workshop summary report.

Lawrence X. Yu, H. Winkle, S. Preskorn, 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Biowaiver monographs for immediate release solid oral dosage forms: Doxycycline hyclate.

D. Barends, G. Amidon, H. Junginger, 2010, Journal of pharmaceutical sciences.

Challenges and opportunities in establishing scientific and regulatory standards for determining therapeutic equivalence of modified-release products: Workshop summary report.

Lawrence X. Yu, H. Winkle, S. Preskorn, 2010, Clinical therapeutics.

Elevation of plasma concentrations of haloperidol after the addition of fluoxetine.

D. Goff, R. Baldessarini, K. Midha, 1991, The American journal of psychiatry.

Investigation of pharmacokinetic and pharmacodynamic interactions after coadministration of nefazodone and haloperidol.

K. Midha, R. Barbhaiya, U. Shukla, 1996, Journal of clinical psychopharmacology.

Identification of phase-I and phase-II metabolites of fluphenazine in rat bile. Intact glucuronide and sulfate conjugates.

K. Midha, J. Hubbard, C. Jackson, 1991, Drug metabolism and disposition: the biological fate of chemicals.

Individual bioequivalence--has its time come?

K. Midha, L. Endrenyi, 1998, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Persistence of fluphenazine in plasma after decanoate withdrawal.

K. Nuechterlein, K. Midha, M. Gitlin, 1988, Journal of Clinical Psychopharmacology.

The bioequivalence of highly variable drugs and drug products.

K. Midha, J. Hubbard, M. Rawson, 2005, International journal of clinical pharmacology and therapeutics.

Exposure measures applied to the bioequivalence of two sustained release formulations of bupropion.

K. Midha, J. Hubbard, G. Mckay, 2005, International journal of clinical pharmacology and therapeutics.

Challenges and Opportunities in Establishing Scientific and Regulatory Standards for Assuring Therapeutic Equivalence of Modified Release Products: Workshop Summary Report

Lawrence X. Yu, H. Winkle, S. Preskorn, 2010, The AAPS Journal.

Evidence for the Lack of a Human Metabolic Isotope Effect of a Deuterium Analog of Fluphenazine

K. Midha, J. Hubbard, G. Mckay, 1995, Pharmaceutical Research.

Kinetics of oral trifluoperazine disposition in man.

K. Midha, G. Mckay, R. Verbeeck, 1983, British journal of clinical pharmacology.

3-O-methyl-alpha-methyldopamine, a urinary metabolite of p-methoxyamphetamine in dog and monkey.

K. Midha, J. Hubbard, J. Cooper, 1981, Drug metabolism and disposition: the biological fate of chemicals.

The role of metabolites in a bioequivalence study 1: loxapine, 7-hydroxyloxapine and 8-hydroxyloxapine.

K. Midha, J. Hubbard, G. Mckay, 1993, International journal of clinical pharmacology, therapy, and toxicology.

S-OXIDATION OF THIORIDAZINE TO PSYCHOACTIVE METABOLITES: AN ORAL DOSE-PROPORTIONALITY STUDY IN HEALTHY VOLUNTEERS

K. Midha, J. Hubbard, G. Mckay, 1988, Drug metabolism and drug interactions.

Plasma concentrations of trifluoperazine following single low doses.

K. Midha, J. Hubbard, D. Keegan, 1983, Canadian Medical Association journal.

Intersubject Variation in the Pharmacokinetics of Haloperidol and Reduced Haloperidol

G McKay, K. Midha, J. Hubbard, 1989, Journal of clinical psychopharmacology.

Biowaiver monographs for immediate release solid oral dosage forms: quinidine sulfate.

D. Barends, J. Polli, H. Junginger, 2009, Journal of pharmaceutical sciences.

Adverse Effects of Fenfluramine in Treatment Refractory Schizophrenia

R. Liberman, J. Mintz, K. Midha, 1989, Journal of clinical psychopharmacology.

Generic products of antiepileptic drugs: A perspective on bioequivalence and interchangeability

K. Midha, M. Bialer, Kamal K. Midha, 2009, Epilepsia.

Stereoselective urinary pharmacokinetics of dl-threo-methylphenidate and its major metabolite in humans.

K. Midha, J. Hubbard, N. Srinivas, 1992, Journal of Pharmacy and Science.

Enantioselective gas chromatographic assay with electron-capture detection for dl-ritalinic acid in plasma.

K. Midha, J. Hubbard, N. Srinivas, 1990, Journal of chromatography.

Pharmacokinetics of chlorpromazine and key metabolites

K. Midha, J. Hubbard, E. Korchinski, 2004, European Journal of Clinical Pharmacology.

Biowaiver monographs for immediate release solid oral dosage forms: ciprofloxacin hydrochloride.

D. Barends, H. Junginger, S. Stavchansky, 2011, Journal of pharmaceutical sciences.

Biowaiver monographs for immediate release solid oral dosage forms: acetaminophen (paracetamol).

D. Barends, G. Amidon, H. Junginger, 2006, Journal of pharmaceutical sciences.

D. Barends, G. Amidon, H. Junginger, 2004, Journal of pharmaceutical sciences.

Biowaiver monographs for immediate release solid oral dosage forms: mefloquine hydrochloride.

D. Barends, J. Polli, H. Junginger, 2011, Journal of pharmaceutical sciences.

Biowaiver monographs for immediate release solid oral dosage forms: isoniazid.

D. Barends, G. Amidon, H. Junginger, 2007, Journal of Pharmacy and Science.

Biowaiver monographs for immediate release solid oral dosage forms: furosemide.

D. Barends, H. Junginger, S. Stavchansky, 2010, Journal of pharmaceutical sciences.

Biowaiver monographs for immediate release solid oral dosage forms: metronidazole.

D. Barends, H. Junginger, S. Stavchansky, 2011, Journal of pharmaceutical sciences.