R. Kühne

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PREDICTING AQUEOUS SOLUBILITY FROM STRUCTURE

J. Wichard, R. Kühne, 2009 .

Molecular Evolution of a Peptide GPCR Ligand Driven by Artificial Neural Networks

Ronald Kühne, Sebastian Bandholtz, Carsten Grötzinger, 2012, PloS one.

Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope.

H Oschkinat, J. Schneider-Mergener, R. Kühne, 2001, Journal of molecular biology.

Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules

Ronald Kühne, Gerhard Wagner, Christian Freund, 2002, The EMBO journal.

Design of chemical libraries with potentially bioactive molecules applying a maximum common substructure concept

Jörg Rademann, Bernd Rupp, Ronald Kühne, 2009, Molecular Diversity.

Chemogenomic Analysis of G-Protein Coupled Receptors and Their Ligands Deciphers Locks and Keys Governing Diverse Aspects of Signalling

Jörg D. Wichard, Ronald Kühne, Gerd Krause, 2011, PloS one.

A Single Glycine-Alanine Exchange Directs Ligand Specificity of the Elephant Progestin Receptor

Anna K. Schrey, R. Kühne, M. Wierer, 2012, PloS one.

Residues within transmembrane helices 2 and 5 of the human gonadotropin-releasing hormone receptor contribute to agonist and antagonist binding.

R. Kühne, H. Reiländer, S. Hoffmann, 2000, Molecular endocrinology.

Pd‐Catalyzed Asymmetric N‐Allylation of Amino Acid Esters with Exceptional Levels of Catalyst Control: Stereo‐Divergent Synthesis of ProM‐15 and Related Bicyclic Dipeptide Mimetics

R. Kühne, J. Neudörfl, H. Schmalz, 2020, Chemistry.

Building a MCHR1 homology model provides insight into the receptor-antagonist contacts that are important for the development of new anti-obesity agents.

Anna K. Schrey, R. Kühne, A. Monge, 2010, Bioorganic & medicinal chemistry.

Impact of aromatic residues within transmembrane helix 6 of the human gonadotropin-releasing hormone receptor upon agonist and antagonist binding.

R. Kühne, S. Hövelmann, H. Reiländer, 2002, Biochemistry.

Metal-free, regioselective triazole ligations that deliver locked cis peptide mimetics.

P. Schmieder, R. Kühne, J. Rademann, 2009, Angewandte Chemie.

Ena/VASP proteins at the crossroads of actin nucleation pathways in dendritic cell migration

R. Kühne, T. Maritzen, Fan Liu, 2022, bioRxiv.

Drug Design. Dependence of hydrophobicity on solvent and structure

R. Kühne, R. Franke, S. Dove, 1983 .

Structure-function studies of linear and cyclized peptide antagonists of the GnRH receptor.

R. Kühne, S. Hoffmann, M. Bernd, 2001, Biochemical and biophysical research communications.

Mutation Ala(171)Thr stabilizes the gonadotropin-releasing hormone receptor in its inactive conformation, causing familial hypogonadotropic hypogonadism.

R. Kühne, E. Milgrom, N. de Roux, 2003, The Journal of clinical endocrinology and metabolism.

Mutational Analysis of the Antagonist-binding Site of the Histamine H1 Receptor*

R. Leurs, R. Kühne, M. Smit, 1999, The Journal of Biological Chemistry.

Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment

R. Kühne, K. Schulze-Osthoff, C. Freund, 2008, Cell Death and Differentiation.

Hydrophobicity and Hydrophobic Interactions I. On the Physical Nature of Aromatic Hydrophobic Substituent Constants

R. Kühne, R. Franke, S. Dove, 1979 .

Exercises in pyrrolidine chemistry: gram scale synthesis of a Pro-Pro dipeptide mimetic with a polyproline type II helix conformation.

R. Kühne, J. Neudörfl, H. Schmalz, 2011, Chemistry.

Triple‐Helix‐Stabilizing Effects in Collagen Model Peptides Containing PPII‐Helix‐Preorganized Diproline Modules

U. Baumann, R. Kühne, J. Neudörfl, 2020, Angewandte Chemie.

Design and Synthesis of Building Blocks for PPII‐Helix Secondary‐Structure Mimetics: A Stereoselective Entry to 4‐Substituted 5‐Vinylprolines

R. Kühne, R. Opitz, Matthias M. Müller, 2018 .

Design and Stereoselective Synthesis of ProM-2: A Spirocyclic Diproline Mimetic with Polyproline Type II (PPII) Helix Conformation.

R. Kühne, R. Opitz, J. Neudörfl, 2015, Chemistry.

Addressing protein-protein interactions with small molecules: a Pro-Pro dipeptide mimic with a PPII helix conformation as a module for the synthesis of PRD-binding ligands.

R. Kühne, H. Oschkinat, R. Opitz, 2010, Angewandte Chemie.

Solution‐State 15N NMR Spectroscopic Study of α‐C‐Phycocyanin: Implications for the Structure of the Chromophore‐Binding Pocket of the Cyanobacterial Phytochrome Cph1

P. Schmieder, R. Kühne, Janina Hahn, 2007, Chembiochem : a European journal of chemical biology.

Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers

Ronald Kühne, Benjamin Bardiaux, Victoria A. Higman, 2010, Nature Structural &Molecular Biology.

Anchor Side Chains of Short Peptide Fragments Trigger Ligand-Exchange of Class II MHC Molecules

Bernd Rupp, Ronald Kühne, Karl-Heinz Wiesmüller, 2008, PloS one.

Small Organic Compounds Enhance Antigen Loading of Class II Major Histocompatibility Complex Proteins by Targeting the Polymorphic P1 Pocket*♦

Christian Freund, Shashank Gupta, R. Kühne, 2006, Journal of Biological Chemistry.

Characterization of Structural Features Controlling the Receptiveness of Empty Class II MHC Molecules

Andreas Schlundt, Bernd Rupp, Ronald Kühne, 2011, PloS one.

The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA.

H Oschkinat, P. Schmieder, A. Rich, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Proline-rich sequence recognition domains (PRD): ligands, function and inhibition.

R. Kühne, J. Sticht, C. Freund, 2008, Handbook of experimental pharmacology.

Chimaeric gonadotropin-releasing hormone (GnRH) peptides with improved affinity for the catfish (Clarias gariepinus) GnRH receptor.

R. Leurs, R. Kühne, M. Blomenröhr, 2002, The Biochemical journal.

A modular toolkit to inhibit proline-rich motif–mediated protein–protein interactions

P. Schmieder, R. Kühne, B. Wiesner, 2015, Proceedings of the National Academy of Sciences.

Recognition of proline-rich motifs by protein-protein-interaction domains.

Ronald Kühne, Jens Schneider-Mergener, Hartmut Oschkinat, 2005, Angewandte Chemie.

Structural investigations of a GYF domain covalently linked to a proline-rich peptide

E. Reinherz, G. Wagner, R. Kühne, 2003, Journal of biomolecular NMR.

The oxidized subunit B8 from human complex I adopts a thioredoxin fold.

P. Schmieder, B. Korn, R. Kühne, 2004, Structure.

Design of a General‐Purpose European Compound Screening Library for EU‐OPENSCREEN

Dragos Horvath, Gilles Marcou, Jordi Mestres, 2014, ChemMedChem.

Dual epitope recognition by the VASP EVH1 domain modulates polyproline ligand specificity and binding affinity

P. Schmieder, J. Schneider-Mergener, R. Kühne, 2000, The EMBO journal.

Stereoselective Synthesis of Tricyclic Diproline Analogues that Mimic a PPII Helix: Structural Consequences of Ring-Size Variation

R. Kühne, N. Schlörer, J. Neudörfl, 2014 .

Stereoselective Synthesis of Proline‐Derived Dipeptide Scaffolds (ProM‐3 and ProM‐7) Rigidified in a PPII Helix Conformation

R. Kühne, J. Neudörfl, H. Schmalz, 2014 .

The NMR structure of the 47-kDa dimeric enzyme 3,4-dihydroxy-2-butanone-4-phosphate synthase and ligand binding studies reveal the location of the active site

P. Schmieder, A. Bacher, R. Kühne, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Design of N-substituted Peptomer Ligands for EVH1 Domains*

Hartmut Oschkinat, J. Zimmermann, R. Kühne, 2003, Journal of Biological Chemistry.

Relationship between Polarographic Adsorption Data and Hydrophobicity

R. Kühne, R. Franke, J. Dittrich, 1983 .

Synthetic α‐Helical Peptides as Potential Inhibitors of the ACE2 SARS‐CoV‐2 Interaction

R. Kühne, C. Hackenberger, J. Neudörfl, 2022, Chembiochem : a European journal of chemical biology.

Efficient α-helix induction in a linear peptide chain by N-capping with a bridged-tricyclic diproline analogue.

P. Schmieder, R. Kühne, R. Opitz, 2013, Angewandte Chemie.

Antagonist and agonist binding models of the human gonadotropin-releasing hormone receptor.

R. Kühne, K. Paulini, E. Günther, 2005, Biochemical and biophysical research communications.

Solution Structure of Human Cofilin

R. Kühne, A. Weeds, Linda J. Ball, 2004, Journal of Biological Chemistry.

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

P. Schmieder, P. Lindemann, R. Kühne, 2020, Proceedings of the National Academy of Sciences.

Solution structure, backbone dynamics, and association behavior of the C-terminal BRCT domain from the breast cancer-associated protein BRCA1.

P. Schmieder, R. Kühne, U. Heinemann, 2004, Biochemistry.

The solution structure of the SODD BAG domain reveals additional electrostatic interactions in the HSP70 complexes of SODD subfamily BAG domains

K. Büssow, D. Labudde, R. Kühne, 2004, FEBS letters.

Intramolecular bridges formed by photoswitchable click amino acids

R. Kühne, C. Hoppmann, M. Beyermann, 2012, Beilstein journal of organic chemistry.

Direct identification of the agonist binding site in the human brain cholecystokininB receptor.

E. Kojro, F. Fahrenholz, R. Kühne, 1999, Biochemistry.

11th German Conference on Chemoinformatics (GCC 2015)

Timothy Clark, Jonathan W. Essex, Peter Kolb, 2016, Journal of Cheminformatics.

Interaction of the antimicrobial peptide cyclo(RRWWRF) with membranes by molecular dynamics simulations.

P. Schmieder, R. Kühne, F. Eisenmenger, 2005, Biophysical journal.

The structures of the active center in dark-adapted bacteriorhodopsin by solution-state NMR spectroscopy

P. Schmieder, D. Oesterhelt, R. Kühne, 2002, Proceedings of the National Academy of Sciences of the United States of America.

The contributions of specific amino acid side chains to signal intensities of peptides in matrix-assisted laser desorption/ionization mass spectrometry.

Ronald Kühne, Holger Wenschuh, H. Wenschuh, 2004, Rapid communications in mass spectrometry : RCM.

Crystal structure of a ProM2 containing triple-helical collagen peptide.

U. Baumann, R. Kühne, J. Neudörfl, 2020 .

Binding site detection via mutual information

Jörg D. Wichard, Ronald Kühne, Antonius ter Laak, 2008, 2008 IEEE International Conference on Fuzzy Systems (IEEE World Congress on Computational Intelligence).

Redox-regulated conformational changes in an SH3 domain.

J. Zimmermann, R. Kühne, M. Sylvester, 2007, Biochemistry.

Topology Preserving Neural Networks for Peptide Design in Drug Discovery

Jörg D. Wichard, Ronald Kühne, Sebastian Bandholtz, 2009, CIBB.

Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists.

R. Kühne, H. Pertz, W. Schunack, 2000, Journal of medicinal chemistry.

Exercises in pyrrolidine chemistry: gram scale synthesis of a Pro-Pro dipeptide mimetic with a polyproline type II helix conformation.

R. Kühne, J. Neudörfl, H. Schmalz, 2011, Chemistry.