E. Coto

F. Setién, E. Coto, C. López-Larrea, 1996, European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics.

Genetic detection of the silent allele (*Q0) in hereditary deficiencies of the human complement C6, C7, and C9 components.

F. Setién, V. Álvarez, E. Coto, 1995, American journal of medical genetics.

Genetic and clinical peculiarities in a new family with hereditary hypophosphatemic rickets with hypercalciuria: a case report

Fernando Santos, E. Coto, F. Santos, 2010, Orphanet journal of rare diseases.

Variation at the Angiotensin-Converting Enzyme and Endothelial Nitric Oxide Synthase Genes Is Associated With the Risk of Esophageal Varices Among Patients With Alcoholic Cirrhosis

V. Álvarez, E. Coto, L. Rodrigo, 2001, Journal of Cardiovascular Pharmacology.

Association between the NOS3 (-786 T/C) and the ACE (I/D) DNA genotypes and early coronary artery disease.

V. Álvarez, E. Coto, A. Batalla, 2001, Nitric oxide : biology and chemistry.

Synergistic effect between apolipoprotein E and angiotensinogen gene polymorphisms in the risk for early myocardial infarction.

V. Álvarez, E. Coto, A. Batalla, 2000, Clinical chemistry.

Angiotensin converting enzyme and endothelial nitric oxide synthase DNA polymorphisms and late onset Alzheimer's disease

V. Álvarez, E. Coto, J. Salas-Puig, 1999, Journal of neurology, neurosurgery, and psychiatry.

Meta-analysis of genetic association with diagnosed Alzheimer’s disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing

J. Gallacher, M. Fornage, I. Giegling, 2018, bioRxiv.

DNA genotyping of the ABO gene showed a significant association of the A-group (A1/A2 variants) with severe COVID-19.

E. Coto, G. M. Albaiceta, Juan Gómez, 2021, European Journal of Internal Medicine.

Effect of the FTO rs9930506 polymorphism on obesity and the main clinical outcomes in patients with psoriasis

E. Coto, P. Coto-Segura, J. Santos-Juanes, 2014, The British journal of dermatology.

ACE gene I/D polymorphism and severity of SARS-CoV-2 infection in hospitalized patients: a meta-analysis

E. Coto, R. Romero-Ortuño, X. Vidal, 2021, Arterial Hypertension.

A Semiconductor Chip-Based Next Generation Sequencing Procedure for the Main Pulmonary Hypertension Genes

E. Coto, C. Morís, C. Alvarez, 2015, Lung.

Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease

P. Bosco, Y. Kamatani, G. Spalletta, 2012, Molecular Psychiatry.

Erratum: Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease (Molecular Psychiatry (2013) 18 (521) DOI: 10.1038/mp.2012.75))

P. Bosco, Y. Kamatani, G. Spalletta, 2013 .

Renin-angiotensin system polymorphisms and renal scarring

V. Álvarez, E. Coto, C. Loris, 2003, Pediatric Nephrology.

Association of matrix Gla protein gene functional polymorphisms with loss of bone mineral density and progression of aortic calcification

E. Coto, J. Cannata-Andía, J. B. Díaz-lópez, 2014, Osteoporosis International.

Familial Hypercholesterolemia in Premature Acute Coronary Syndrome. Insights from CholeSTEMI Registry

E. Coto, P. Avanzas, S. Hevia, 2020, Journal of clinical medicine.

The screening of the 3′UTR sequence of LRRK2 identified an association between the rs66737902 polymorphism and Parkinson’s disease

V. Álvarez, E. Coto, I. Mata, 2014, Journal of Human Genetics.

A 3’-UTR Polymorphism in Soluble Epoxide Hydrolase Gene Is Associated with Acute Rejection in Renal Transplant Recipients

E. Coto, G. Gervasini, B. Suarez-Alvarez, 2015, PloS one.

A complete mutation screen of PKHD1 in autosomal-recessive polycystic kidney disease (ARPKD) pedigrees.

Roser Torra, E. Coto, V. Torres, 2003, Kidney international.

A physical map of the human complement component C6, C7, and C9 genes

F. Setién, V. Álvarez, E. Coto, 2004, Immunogenetics.

Soluble Co-Signaling Molecules Predict Long-Term Graft Outcome in Kidney-Transplanted Patients

E. Coto, B. Suarez-Alvarez, C. López-Larrea, 2014, PloS one.

Genetic variants in the NF-κB signaling pathway (NFKB1, NFKBIA, NFKBIZ) and risk of critical outcome among COVID-19 patients

E. Coto, G. M. Albaiceta, E. Cuesta-Llavona, 2022, Human Immunology.

Mitochondrial transcription factor A (TFAM) gene variation and risk of late-onset Alzheimer's disease.

V. Álvarez, E. Coto, M. García-Castro, 2008, Journal of Alzheimer's disease : JAD.

Genetic diagnosis of autosomal dominant polycystic kidney disease: linkage analysis versus direct mutation analysis

E. Coto, R. Torra, N. Bogdanova, 2016 .

Association between an alpha(2) macroglobulin DNA polymorphism and late-onset Alzheimer's disease.

V. Álvarez, E. Coto, J. Salas-Puig, 1999, Biochemical and biophysical research communications.

Use of a Second Device for the Closure of Patent Foramen Ovale

E. Coto, I. Rodriguez, M. Palacín, 2017 .

Metalloproteinase polymorphisms and bicuspid aortic valves.

E. Coto, María Martín, I. Rodríguez, 2010, Revista espanola de cardiologia.

Pharmacogenetics of Calcineurin Inhibitors in Renal Transplantation

E. Coto, B. Tavira, 2009, Transplantation.

Genetic variation in APOE, GRN, and TP53 are phenotype modifiers in frontotemporal dementia

C. Broeckhoven, S. Sorbi, V. Álvarez, 2020, Neurobiology of Aging.

Early-onset Parkinson’s disease associated with a new parkin mutation in a Spanish family

V. Álvarez, E. Coto, C. Lahoz, 2001, Neuroscience Letters.

Association between the Stin2 VNTR polymorphism of the serotonin transporter gene and treatment outcome in alcohol-dependent patients.

J. Bobes, P. Sáiz, V. Álvarez, 2008, Alcohol and alcoholism.

Alpha-synuclein transcript isoforms in three different brain regions from Parkinson's disease and healthy subjects in relation to the SNCA rs356165/rs11931074 polymorphisms

V. Álvarez, E. Coto, I. Mata, 2014, Neuroscience Letters.

The Pro279Leu variant in the transcription factor MEF2A is associated with myocardial infarction

V. Álvarez, E. Coto, A. Batalla, 2005, Journal of Medical Genetics.

SPG7 mutational screening in spastic paraplegia patients supports a dominant effect for some mutations and a pathogenic role for p.A510V

V. Álvarez, E. Coto, J. Infante, 2013, Clinical genetics.

Interleukin‐1 Gene Complex in Schizophrenia: An Association Study *

J. Bobes, P. Sáiz, C. Arango, 2006, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Genetic alterations in squamous cell carcinomas of the hypopharynx with correlations to clinicopathological features.

E. Coto, J. Rodrigo, C. Suárez, 2002, Oral oncology.

Genetic polymorphism of N-acetyltransferase-2, glutathione S-transferase-M1, and cytochromes P450IIE1 and P450IID6 in the susceptibility to head and neck cancer.

V. Álvarez, E. Coto, María Verónica González, 1998, Journal of clinical pathology.

Gitelman syndrome: a review of clinical features, genetic diagnosis and therapeutic management

E. Coto, F. Santos, H. Gil-Peña, 2016 .

Psoriasis and type 2 diabetes risk among psoriatic patients in a Spanish population

E. Coto, P. Coto-Segura, P. Martínez-Camblor, 2012, The Australasian journal of dermatology.

Mutational screening of the mortalin gene (HSPA9) in Parkinson’s disease

V. Álvarez, E. Coto, M. Blázquez, 2009, Journal of Neural Transmission.

Mutational screening of the mitochondrial transcription factors B1 and B2 (TFB1M and TFB2M) in Parkinson's disease.

V. Álvarez, E. Coto, M. Blázquez, 2009, Parkinsonism & related disorders.

Mitochondrial transcription factor A (TFAM) gene variation in Parkinson's disease

V. Álvarez, E. Coto, M. Blázquez, 2008, Neuroscience Letters.

Chemokines (RANTES and MCP-1) and chemokine-receptors (CCR2 and CCR5) gene polymorphisms in Alzheimer's and Parkinson's disease

V. Álvarez, E. Coto, I. Mata, 2004, Neuroscience Letters.

FURIN gene variants (rs6224/rs4702) as potential markers of death and cardiovascular traits in severe COVID‐19

V. Álvarez, E. Coto, G. M. Albaiceta, 2022, Journal of medical virology.

Lack of association between polymorphisms of the coagulation factor VII and myocardial infarction in middle-aged Spanish men.

V. Álvarez, E. Coto, A. Batalla, 2001, International journal of cardiology.

Pharmacogenetics of tacrolimus: ready for clinical translation?

V. Álvarez, E. Coto, B. Suarez-Alvarez, 2011, Kidney international supplements.

Novel Polymorphisms of Nuclear Receptor SHP Associated with Functional and Structural Changes

E. Coto, Zhihong Yang, R. Pellicciari, 2010, The Journal of Biological Chemistry.

Association between the interferon-induced transmembrane protein 3 gene (IFITM3) rs34481144 / rs12252 haplotypes and COVID-19

E. Coto, E. Cuesta-Llavona, Daniel Vázquez-Coto, 2021, Current Research in Virological Science.

The Interferon-induced transmembrane protein 3 gene (IFITM3) rs12252 C variant is associated with COVID-19.

V. Álvarez, E. Coto, H. Gil-Peña, 2020, Cytokine.

A first update on mapping the human genetic architecture of COVID-19

Eurie L. Hong, E. F. Perez, Rachel G Liao, 2022, Nature.

, from Apoptosis in Osteomyelitis In Vivo Interleukin-6 Protects Neutrophils

J. M. Arribas, Á. Meana, E. Coto, 2004 .

Genetic Variants of the NF-κB Pathway: Unraveling the Genetic Architecture of Psoriatic Disease

E. Coto, R. Queiró, L. González-Lara, 2021, International journal of molecular sciences.

Association between single nucleotide polymorphisms IL17RA rs4819554 and IL17E rs79877597 and Psoriasis in a Spanish cohort.

E. Coto, P. Coto-Segura, C. López-Larrea, 2015, Journal of dermatological science.

The Renin–Angiotensin–Aldosterone System and Coronavirus Disease 2019

E. Coto, P. Avanzas, Juan Gómez, 2021, European cardiology.

The CCR5-delta32 variant might explain part of the association between COVID-19 and the chemokine-receptor gene cluster

V. Álvarez, E. Coto, J. Gómez, 2020, medRxiv.

Genetic variation at the CCR5/CCR2 gene cluster and risk of psoriasis and psoriatic arthritis.

V. Álvarez, E. Coto, P. Coto-Segura, 2010, Cytokine.

Genetic and clinical studies in autosomal dominant polycystic kidney disease type 1 (ADPKD1).

E. Coto, C. López-Larrea, S. Aguado, 1992, Journal of medical genetics.

Smoking is associated with age at disease onset in Parkinson's disease.

J. Hoenicka, E. Tolosa, J. Kulisevsky, 2022, Parkinsonism & related disorders.

The spectrum of SCN5A gene mutations in Spanish Brugada syndrome patients.

V. Álvarez, E. Coto, J. Rubín, 2010, Revista espanola de cardiologia.

Espectro mutacional del gen SCN5A en pacientes españoles con síndrome de Brugada

V. Álvarez, E. Coto, J. Rubín, 2010 .

Profile of microRNAs differentially produced in hearts from patients with hypertrophic cardiomyopathy and sarcomeric mutations.

V. Álvarez, E. Coto, María Martín, 2011, Clinical chemistry.

Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Nick C Fox, Michelle K. Lupton, Charles C. White, 2019, Nature Genetics.

Cancer in Parkinson’s Disease: An Approximation to the Main Risk Factors

V. Álvarez, E. Coto, M. Menéndez-González, 2021, Neurodegenerative Diseases.

Molecular typing of HLA-B27 alleles

E. Coto, C. López-Larrea, S. Choo, 2004, Immunogenetics.

DNA analysis of HLA-DR4B1 subtypes in multiple sclerosis by specific oligonucleotide probes

E. Coto, C. López-Larrea, E. Martínez-Naves, 1991, Journal of Neuroimmunology.

Hypertrophic cardiomyopathy and left ventricular non-compaction: Different manifestations of the same cardiomyopathy spectrum?

E. Coto, María Martín, C. Morís, 2015, International journal of cardiology.

Genetic Screening of a Large Panel of Genes Associated with Cardiac Disease in a Spanish Heart Transplanted Cohort

E. Coto, B. Díaz-Molina, J. Reguero, 2022, Cardiogenetics.

IL‐15 preferentially enhances functional properties and antigen‐specific responses of CD4+CD28null compared to CD4+CD28+ T cells

E. Coto, C. López-Larrea, F. Suárez-García, 2011, Aging cell.

Gene Variant in the NF-κB Pathway Inhibitor NFKBIA Distinguishes Patients with Psoriatic Arthritis within the Spectrum of Psoriatic Disease

E. Coto, P. Coto-Segura, R. Queiró, 2019, BioMed research international.

Different Phenotypes in Monozygotic Twins, Carriers of the Same Pathogenic Variant for Hypertrophic Cardiomyopathy

E. Coto, P. Avanzas, C. Morís, 2022, Life.

Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome

V. Álvarez, E. Coto, C. López-Larrea, 2020, Gene.

Mutational spectrum of the SPG4 (SPAST) and SPG3A (ATL1) genes in Spanish patients with hereditary spastic paraplegia

V. Álvarez, E. Coto, J. Rosell, 2010, BMC neurology.

Mutational spectrum of the SPG 4 ( SPAST ) and SPG 3 A ( ATL 1 ) genes in Spanish patients with hereditary spastic paraplegia

V. Álvarez, E. Coto, J. Rosell, 2010 .

IL‐1α (− 889) promoter polymorphism is a risk factor for osteomyelitis

J. M. Arribas, V. Álvarez, S. Llames, 2003 .

Chromosome 3p loss of heterozygosity and mutation analysis of the FHIT and beta-cat genes in squamous cell carcinoma of the head and neck.

V. Álvarez, E. Coto, María Verónica González, 1998, Journal of clinical pathology.

Chromosome 3 p loss of heterozygosity and mutation analysis of the FHIT and â-cat genes in squamous cell carcinoma of the head and neck

V. Álvarez, E. Coto, C. Suárez, 1998 .

SNP rs11652075 in the CARD14 gene as a risk factor for psoriasis (PSORS2) in a Spanish cohort.

E. Coto, P. Coto-Segura, J. Santos-Juanes, 2013, DNA and cell biology.

Characterization of Left Ventricular Non-Compaction Cardiomyopathy

E. Coto, A. Astudillo, P. Avanzas, 2020, Journal of clinical medicine.

New polymorphisms in human MEF2C gene as potential modifier of hypertrophic cardiomyopathy

E. Coto, J. Cannata-Andía, M. Naves-Díaz, 2012, Molecular Biology Reports.

NFKBIZ in Psoriasis: Assessing the association with gene polymorphisms and report of a new transcript variant.

E. Coto, P. Coto-Segura, R. Queiró, 2017, Human immunology.

Ventilation disorders diagnosed preoperatively in patients scheduled for isolated on-pump CABG: Do they increase inflammatory response in the early postoperative period?

Aleks, E. Coto, M. Brykczyński, 2016 .

Mitochondrial DNA polymorphisms/haplogroups in hereditary spastic paraplegia

V. Álvarez, E. Coto, J. Infante, 2012, Journal of Neurology.

The NOS3 (27-bp repeat, intron 4) polymorphism is associated with susceptibility to osteomyelitis.

V. Álvarez, Á. Meana, E. Coto, 2007, Nitric oxide : biology and chemistry.

Left ventricular non-compaction associated with a MYH7 splicing variant (c.818+1G>A)

E. Coto, C. Corros, J. Reguero, 2022, Journal of Clinical Images and Medical Case Reports.

Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project

Yurii S. Aulchenko, M. Arfan Ikram, Mario Cortina-Borja, 2012, Neurobiology of Aging.

DNA polymorphisms and linkage relationship of the human complement componentC6,C7, andC9 genes

E. Coto, C. López-Larrea, R. Discipio, 2005, Immunogenetics.

Bilineal inheritance of type 1 autosomal dominant polycystic kidney disease (ADPKD) and recurrent fetal loss

E. Coto, R. Peces, C. Peces, 2008, NDT plus.

Surveillance after cardiac arrest in patients with Brugada syndrome without an implantable defibrillator: An alarm effect of the previous syncope.

E. Coto, D. Calvo, J. Rubín, 2016, International journal of cardiology.

Role of syncope in predicting adverse outcomes in patients with suspected Brugada syndrome undergoing standardized flecainide testing.

E. Coto, D. Calvo, J. Rubín, 2018, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

IL17RA gene variants and anti-TNF response among psoriasis patients

E. Coto, M. Llamas-Velasco, J. Gómez, 2016, The Pharmacogenomics Journal.

An elderly Jervell and Lange‐Nielsen patient heterozygous compound for two new KCNQ1 mutations

E. Coto, D. Calvo, B. Alonso, 2017, American journal of medical genetics. Part A.

Characterization of B27 haplotypes by oligotyping and genomic sequencing in the Mexican Mestizo population with ankylosing spondylitis: juvenile and adult onset.

V. Álvarez, E. Coto, R. Burgos-Vargas, 1995, Human immunology.

HLA CLASS II AND SUSCEPTIBILITY AND RESISTANCE TO INSULIN‐DEPENDENT DIABETES MELLITUS IN A POPULATION FROM THE NORTHWEST OF SPAIN

E. Coto, C. López-Larrea, E. Martínez-Naves, 1994, European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics.

1.P.229 Polymorphisms of the platelet receptor IIIa and lipid levels in early coronary disease

E. Coto, A. Batalla, S. Hevia, 1997 .

Molecular analysis of HLA-B27 haplotypes in Caucasoids. Frequencies of B27-Cw in Jewish and Spanish populations.

V. Álvarez, E. Coto, C. López-Larrea, 1994, Human immunology.

The Cw6 and late-cornified envelope genotype plays a significant role in anti-tumor necrosis factor response among psoriatic patients.

E. Coto, P. Coto-Segura, J. Santos-Juanes, 2015, Pharmacogenetics and genomics.

Apolipoprotein E genotype and coronary heart disease.

E. Coto, A. Batalla, S. Hevia, 2001, Journal of the American College of Cardiology.

Vesicoureteric reflux and tumor necrosis factor-alpha gene polymorphism.

V. Álvarez, E. Coto, S. Málaga, 2007, Journal of pediatric urology.

The T-786C endothelial nitric oxide synthase genotype and coronary artery disease.

E. Coto, A. Batalla, J. Reguero, 2003, Journal of the American College of Cardiology.

NKG2D and its ligands: active factors in the outcome of solid organ transplantation?

E. Coto, B. Suarez-Alvarez, C. López-Larrea, 2011, Kidney international supplements.

FK506 affects mitochondrial protein synthesis and oxygen consumption in human cells

E. Coto, E. Ruiz-Pesini, J. Montoya, 2013, Cell Biology and Toxicology.

NFKBIZ and CW6 in Adalimumab Response Among Psoriasis Patients: Genetic Association and Alternative Transcript Analysis

E. Coto, P. Coto-Segura, R. Queiró, 2019, Molecular Diagnosis & Therapy.

Insights Into Hypertrophic Cardiomyopathy Evaluation Through Follow-up of a Founder Pathogenic Variant.

E. Coto, V. León, I. Pascual, 2019, Revista espanola de cardiologia.

Functional polymorphisms in the CYP3A4, CYP3A5, and CYP21A2 genes in the risk for hypertension in pregnancy.

V. Álvarez, E. Coto, A. Ortiz, 2010, Biochemical and biophysical research communications.

Functional polymorphisms in the CYP 3 A 4 , CYP 3 A 5 , and CYP 21 A 2 genes in the risk for hypertension in pregnancy

V. Álvarez, E. Coto, A. Ortiz, 2010 .

A functional Sp1/Egr1‐tandem repeat polymorphism in the 5‐lipoxygenase gene is not associated with myocardial infarction

E. Coto, I. Lozano, C. Morís, 2007, International journal of immunogenetics.

[Direct detection of malignant mutations in patients with hypertrophic cardiomyopathy].

E. Coto, A. Batalla, M. García-Castro, 2003, Revista espanola de cardiologia.

[Pharmacogenetics of tacrolimus: from bench to bedside?].

E. Coto, C. Díaz-Corte, F. Ortega, 2014, Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.

Defining a Methylation Signature Associated With Operational Tolerance in Kidney Transplant Recipients

E. Coto, A. Aransay, J. Lozano, 2021, Frontiers in Immunology.

Mutation analysis of the myocyte enhancer factor 2A gene (MEF2A) in patients with left ventricular hypertrophy/hypertrophic cardiomyopathy

V. Álvarez, E. Coto, C. Morís, 2009, American journal of medical genetics. Part A.

Late-onset Alzheimer's disease is associated with mitochondrial DNA 7028C/haplogroup H and D310 poly-C tract heteroplasmy

V. Álvarez, E. Coto, C. Martínez, 2011, neurogenetics.

A search for cyclophilin‐A gene (PPIA) variation and its contribution to the risk of atherosclerosis and myocardial infarction

V. Álvarez, E. Coto, C. López-Larrea, 2008, International journal of immunogenetics.

Short communication Negative evidences in association between apolipoprotein E polymorphism and panic disorder

J. Bobes, V. Álvarez, E. Coto, 2006 .

Influence of endothelial nitric oxide synthase polymorphisms in psoriasis risk

V. Álvarez, E. Coto, P. Coto-Segura, 2011, Archives of Dermatological Research.

Association of the Genetic Variation in the Long Non-Coding RNA FENDRR with the Risk of Developing Hypertrophic Cardiomyopathy

E. Coto, R. Lorca, J. Rodríguez-Reguero, 2022, Life.

Next generation sequencing of the NOTCH3 gene in a cohort of pulmonary hypertension patients.

E. Coto, C. Morís, C. Alvarez, 2016, International journal of cardiology.

TGFBR2 gene mutational spectrum in aortic pathology.

E. Coto, María Martín, I. Rodríguez, 2011, Journal of the American College of Cardiology.

Prevalence and spectrum of mutations in the sarcomeric troponin T and I genes in a cohort of Spanish cardiac hypertrophy patients.

V. Álvarez, E. Coto, M. García-Castro, 2007, International journal of cardiology.

The Pro 279 Leu variant in the transcription factor MEF 2 A is associated with myocardial infarction

V. Álvarez, E. Coto, A. Batalla, 2005 .

A search for cyclophilin‐A gene variants in cyclosporine A‐treated renal transplanted patients

V. Álvarez, E. Coto, A. Ortiz, 2008, Clinical Transplantation.

Lack of association between angiotensin I‐converting enzyme insertion/deletion polymorphism and psoriasis or psoriatic arthritis in Spain

V. Álvarez, E. Coto, P. Coto-Segura, 2009, International journal of dermatology.

Common European mitochondrial haplogroups in the risk for psoriasis and psoriatic arthritis.

V. Álvarez, E. Coto, P. Coto-Segura, 2012, Genetic testing and molecular biomarkers.

Mitochondrial haplogroup T is negatively associated with the status of elite endurance athlete.

V. Álvarez, E. Coto, N. Terrados, 2007, Mitochondrion.

Mutation analysis of the main hypertrophic cardiomyopathy genes using multiplex amplification and semiconductor next-generation sequencing.

V. Álvarez, E. Coto, María Martín, 2014, Circulation journal : official journal of the Japanese Circulation Society.

Non Optical Semi-Conductor Next Generation Sequencing of the Main Cardiac QT-Interval Duration Genes in Pooled DNA Samples

V. Álvarez, E. Coto, C. Morís, 2014, Journal of Cardiovascular Translational Research.

Tissue-specific effect of VDR gene polymorphisms on the response to calcitriol.

E. Coto, J. Cannata-Andía, C. Gómez-Alonso, 2008, JN. Journal of Nephrology (Milano. 1992).

PCR-based study of the presence of Y-chromosome sequences in patients with Ullrich-Turner syndrome.

E. Coto, C. López-Larrea, A. Plasencia, 1995, American journal of medical genetics.

GENETICS AND CELL BIOLOGY Association Between the STin2 VNTR Polymorphism of the Serotonin Transporter Gene and Treatment Outcome in Alcohol-Dependent Patients

J. Bobes, P. Sáiz, V. Álvarez, 2008 .

Convergent genetic and expression data implicate immunity in Alzheimer's disease

J. Gallacher, K. Lunetta, M. Nalls, 2014, Alzheimer's & Dementia.

Analysis of ras oncogene mutations in human squamous cell carcinoma of the head and neck.

E. Coto, C. López-Larrea, O. Dominguez, 1992, Surgical oncology.

Association between a MYH9 polymorphism (rs3752462) and renal function in the Spanish RENASTUR cohort.

V. Álvarez, E. Coto, F. Ortega, 2013, Gene.

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Nick C Fox, Michelle K. Lupton, Charles C. White, 2019, Nature Genetics.

Germalin repertoire of T-cell receptor β-chain genes in patients with insulin-dependent diabetes mellitus

L. Hood, F. Setién, E. Coto, 1991 .

Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease

M Mancuso, R Ferri, P. Bosco, 2012, Molecular Psychiatry.

Deletion and methylation of the tumour suppressor gene p16/CDKN2 in primary head and neck squamous cell carcinoma.

E. Coto, María Verónica González, C. López-Larrea, 1997, Journal of clinical pathology.

Loss of heterozygosity and mutation analysis of the p16 (9p21) and p53 (17p13) genes in squamous cell carcinoma of the head and neck.

E. Coto, María Verónica González, C. López-Larrea, 1995, Clinical cancer research : an official journal of the American Association for Cancer Research.

Profile of microRNAs in the plasma of Parkinson’s disease patients and healthy controls

V. Álvarez, E. Coto, L. Cardo, 2013, Journal of Neurology.

Mutational Screening of PARKIN Identified a 3′ UTR Variant (rs62637702) Associated with Parkinson’s Disease

V. Álvarez, E. Coto, P. Pástor, 2013, Journal of Molecular Neuroscience.

Analysis of the Micro‐RNA‐133 and PITX3 genes in Parkinson's disease

Marta Blázquez, Pau Pastor, V. Álvarez, 2010, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Variants in cardiac GATA genes associated with bicuspid aortic valve

E. Coto, J. Cannata-Andía, María Martín, 2018, European journal of clinical investigation.

Mutation analysis of the LCE3B/LCE3C genes in Psoriasis

V. Álvarez, E. Coto, P. Coto-Segura, 2010, BMC Medical Genetics.

Clinical Evaluation of Patients with Genetically Confirmed Familial Hypercholesterolemia

E. Coto, C. Martínez-Faedo, Lorena Suárez-Gutiérrez, 2023, Journal of clinical medicine.

Opportunistic Genetic Screening for Familial Hypercholesterolemia in Heart Transplant Patients

E. Coto, P. Avanzas, I. Pascual, 2023, Journal of clinical medicine.

A Next-Generation Sequencing of the NOTCH3 and HTRA1 Genes in CADASIL Patients

E. Coto, B. Alonso, S. Iglesias, 2015, Journal of Molecular Neuroscience.

Characterization of interleukin-8 receptors in non-human primates

F. Setién, V. Álvarez, E. Coto, 1996, Immunogenetics.

MiRNA Profile in the Substantia Nigra of Parkinson’s Disease and Healthy Subjects

V. Álvarez, E. Coto, L. Cardo, 2014, Journal of Molecular Neuroscience.

No differential DNA methylation of PARK2 in brain of Parkinson's disease patients and healthy controls

V. Álvarez, E. Coto, L. Cardo, 2013, Movement disorders : official journal of the Movement Disorder Society.

Differential methylation of lncRNA KCNQ1OT1 promoter polymorphism was associated with symptomatic cardiac long QT.

E. Coto, H. Gil-Peña, D. Calvo, 2017, Epigenomics.

Unified criteria for ultrasonographic diagnosis of ADPKD.

A. Paterson, E. Coto, P. Parfrey, 2009, Journal of the American Society of Nephrology : JASN.

Genotype-renal function correlation in type 2 autosomal dominant polycystic kidney disease.

Ann M. Johnson, P. S. St George-Hyslop, E. Coto, 2003, Journal of the American Society of Nephrology : JASN.

IGHG3 hinge length variation was associated with the risk of critical disease and death in a Spanish COVID-19 cohort

V. Álvarez, E. Coto, H. Gil-Peña, 2022, Genes & Immunity.

Transcriptomic clustering of critically ill COVID-19 patients

A. Dávalos, E. Coto, H. Gil-Peña, 2022, European Respiratory Journal.

Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease

Mario Cortina-Borja, Naomi Hammond, Panos Deloukas, 2013, Neurobiology of Aging.

Effect of mitochondrial, APOE. ACE and NOS3 gene polymorphisms on cardiovascular risk factors among the Vaqueiros de Alzada, a Northern Spain human isolate

E. Coto, Juan Gómez, A. Corao, 2014, Annals of human biology.

Open Access Journal of Neuroinflammation Replication by the Epistasis Project of the Interaction between the Genes for Il-6 and Il-10 in the Risk of Alzheimer's Disease

Mario Cortina-Borja, Rhian Gwilliam, Naomi Hammond, 2022 .

Comparison of phenotypes of polycystic kidney disease types 1 and 2

E. Coto, M. Breuning, D. Ravine, 1999, The Lancet.

Gene variants in the NF-KB pathway (NFKB1, NFKBIA, NFKBIZ) and their association with type 2 diabetes and impaired renal function.

E. Coto, P. Coto-Segura, C. López-Larrea, 2018, Human immunology.

Variability of Genetic Alterations in Different Sites of Head and Neck Cancer

E. Coto, J. Rodrigo, M. V. González, 2001, The Laryngoscope.

Effects of IFIH1 rs1990760 variants on systemic inflammation and outcome in critically ill COVID-19 patients in an observational translational study

E. Coto, Irene Crespo, H. Gil-Peña, 2022, eLife.

IFIH1 rs1990760 variants, systemic inflammation and outcome in critically-ill COVID-19 patients

E. Coto, H. Gil-Peña, C. López-Larrea, 2021, medRxiv.

Evidence of a third ADPKD locus is not supported by reanalysis of designated PKD3 families

E. Coto, M. Clementi, V. Torres, 2013, Kidney international.

KCNQ1 gene variants in the risk for type 2 diabetes and impaired renal function in the Spanish Renastur cohort

V. Álvarez, E. Coto, E. Delgado, 2016, Molecular and Cellular Endocrinology.

KCNQ1 gene variants and risk of new‐onset diabetes in tacrolimus‐treated renal‐transplanted patients

V. Álvarez, E. Coto, R. Selgas, 2011, Clinical transplantation.

Genetic variation at the chemokine receptors CCR5/CCR2 in myocardial infarction

V. Álvarez, E. Coto, A. Batalla, 2001, Genes and Immunity.

Apolipoprotein A1 Gene Polymorphisms and Risk of Early Coronary Disease

V. Álvarez, E. Coto, A. Batalla, 1998, Cardiology.

Hereditary angioedema caused by a novel intronic variant of SERPING1

E. Coto, J. Martínez-Borra, Rocío López-Martínez, 2021, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Genetic variation of DKK3 may modify renal disease severity in ADPKD.

A. Paterson, M. Laakso, E. Coto, 2010, Journal of the American Society of Nephrology : JASN.

Analysis of the CHCHD10 gene in patients with frontotemporal dementia and amyotrophic lateral sclerosis from Spain.

O. Combarros, V. Álvarez, A. Ruiz, 2015, Brain : a journal of neurology.

Screening of the Filamin C Gene in a Large Cohort of Hypertrophic Cardiomyopathy Patients

V. Álvarez, E. Coto, P. Avanzas, 2017, Circulation. Cardiovascular genetics.

Multiple endocrine neoplasia type 1 (MEN1): clinical heterogeneity in a large family with a nonsense mutation in the MEN1 gene (Trp471Stop)

V. Álvarez, E. Coto, L. Castaño, 1999, Clinical endocrinology.

N-acetyltransferase-2 polymorphisms and schizophrenia

J. Bobes, P. Sáiz, C. Arango, 2006, European Psychiatry.

Mutations in filamin C cause a new form of familial hypertrophic cardiomyopathy

X. Puente, R. Valdés-Mas, Diana A. Puente, 2014, Nature Communications.

Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease

P. Bosco, Y. Kamatani, G. Spalletta, 2012, Molecular Psychiatry.

A Single Nucleotide Polymorphism in the Il17ra Promoter Is Associated with Functional Severity of Ankylosing Spondylitis

E. Coto, P. Coto-Segura, C. López-Larrea, 2016, PloS one.

Genetic variation at the long noncoding RNA H19 gene is associated with the risk of hypertrophic cardiomyopathy.

E. Coto, P. Avanzas, María Martín, 2018, Epigenomics.

Next generation sequencing search for uromodulin gene variants related with impaired renal function

E. Coto, S. Tranche, B. Alonso, 2015, Molecular Biology Reports.

HLA-B27 polymorphism and worldwide susceptibility to ankylosing spondylitis.

E. Coto, C. López-Larrea, D. Woodfield, 1997, Tissue antigens.

HLA-B27 subtypes in Asian patients with ankylosing spondylitis. Evidence for new associations.

P Chiewsilp, K Sujirachato, F. Setién, 1995, Tissue antigens.

FK506 affects mitochondrial protein synthesis and oxygen consumption in human cells

E. Coto, E. Ruiz-Pesini, J. Montoya, 2013, Cell Biology and Toxicology.

A Search for SNCA 3′ UTR Variants Identified SNP rs356165 as a Determinant of Disease Risk and Onset Age in Parkinson’s Disease

V. Álvarez, E. Coto, P. Pástor, 2011, Journal of Molecular Neuroscience.

The donor ABCB1 (MDR-1) C3435T polymorphism is a determinant of the graft glomerular filtration rate among tacrolimus treated kidney transplanted patients

E. Coto, C. López-Larrea, B. Tavira, 2015, Journal of Human Genetics.

Effect of CYP3A5, CYP3A4, and ABCB1 genotypes as determinants of tacrolimus dose and clinical outcomes after heart transplantation.

V. Álvarez, E. Coto, B. Tavira, 2012, Transplantation proceedings.

Identification of Epitopes and Immunodominant Regions on the MICA Protein Defined by Alloantibodies From Kidney Transplant Patients

E. Coto, B. Suarez-Alvarez, C. López-Larrea, 2009, Transplantation.

Genotype of an individual single nucleotide polymorphism regulates DNA methylation at the TRPC3 alternative promoter

E. Coto, V. Volpini, D. Monk, 2011, Epigenetics.

Endoplasmic Reticulum Stress Signals in Defined Human Embryonic Stem Cell Lines and Culture Conditions

E. Coto, P. Menéndez, H. Moore, 2010, Stem Cell Reviews and Reports.

[Mutations in sarcomeric genes MYH7, MYBPC3, TNNT2, TNNI3, and TPM1 in patients with hypertrophic cardiomyopathy].

V. Álvarez, E. Coto, M. García-Castro, 2009, Revista espanola de cardiologia.

Myocyte enhancing factor-2A in Alzheimer's disease: Genetic analysis and association with MEF2A-polymorphisms

V. Álvarez, E. Coto, M. García-Castro, 2007, Neuroscience Letters.

Association study of serotonin 2A receptor (5-HT2A) and serotonin transporter (5-HTT) gene polymorphisms with schizophrenia

J. Bobes, P. Sáiz, C. Arango, 2007, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity

V. Álvarez, E. Coto, H. Gil-Peña, 2021, International Immunopharmacology.

Distal renal tubular acidosis. Clinical manifestations in patients with different underlying gene mutations

E. Coto, F. Santos, H. Gil-Peña, 2018, Pediatric Nephrology.

Primary distal renal tubular acidosis: novel findings in patients studied by next-generation sequencing

E. Coto, F. Santos, H. Gil-Peña, 2016, Pediatric Research.

Genetic polymorphisms in the dopamine-2 receptor (DRD2), dopamine-3 receptor (DRD3), and dopamine transporter (SLC6A3) genes in schizophrenia: Data from an association study

L. Fañanás, J. Bobes, P. Corcoran, 2010, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Interactions between functional serotonergic polymorphisms and demographic factors influence personality traits in healthy Spanish Caucasians

J. Bobes, P. Corcoran, P. Sáiz, 2010, Psychiatric genetics.

Association between the A-1438G polymorphism of the serotonin 2A receptor gene and nonimpulsive suicide attempts

J. Bobes, P. Sáiz, C. Arango, 2008, Psychiatric genetics.

Association study between obsessive–compulsive disorder and serotonergic candidate genes

J. Bobes, P. Sáiz, C. Arango, 2008, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations

Hilkka Soininen, Sandro Sorbi, Philippe Amouyel, 2011, Neurobiology of Aging.

Differential role of serotonergic polymorphisms in alcohol and heroin dependence

J. Bobes, P. Corcoran, P. Sáiz, 2009, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Mutational analysis of the CCR5 and CXCR4 genes (HIV-1 co-receptors) in resistance to HIV-1 infection and AIDS development among intravenous drug users

V. Álvarez, E. Coto, C. López-Larrea, 1998, Human Genetics.

Angiotensin-converting enzyme (ACE1, ACE2) gene variants are associated with COVID19 severity depending on the hypertension status.

E. Coto, J. Gómez, C. López-Larrea, 2020, medRxiv.

DNA variation in myoMIRs of the 1, 133, and 208 families in hypertrophic cardiomyopathy

V. Álvarez, E. Coto, María Martín, 2011 .

A spectrum of mutations in the second gene for autosomal dominant polycystic kidney disease (PKD2).

R. Fossdal, E. Coto, S. Somlo, 1997, American journal of human genetics.

Shared genetic contribution to ischemic stroke and Alzheimer's disease

Nick C Fox, C. Sudlow, J. Gallacher, 2016, Annals of neurology.

The FCGR2A rs1801274 polymorphism was associated with the risk of death among COVID-19 patients

V. Álvarez, E. Coto, E. Cuesta-Llavona, 2022, Clinical Immunology.

Distal RTA with nerve deafness: clinical spectrum and mutational analysis in five children

E. Coto, F. Santos, F. A. Ordóñez, 2007, Pediatric Nephrology.

Polymorphisms of the IL-1 gene complex are associated with alcohol dependence in Spanish Caucasians: data from an association study.

J. Leza, J. Bobes, P. Corcoran, 2009, Alcoholism, clinical and experimental research.

A labor and cost effective next generation sequencing of PKHD1 in autosomal recessive polycystic kidney disease patients.

V. Álvarez, E. Coto, A. Plasencia, 2015, Gene.

Haplotype analysis improves molecular diagnostics of autosomal recessive polycystic kidney disease.

V. Pankratz, E. Avner, J. Cunningham, 2005, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Residue 826 in the Calcium-Sensing Receptor Is Implicated in the Response to Calcium and to R-568 Calcimimetic Compound

E. Coto, I. Gonzalez-Suarez, J. Cannata-Andía, 2010, Calcified Tissue International.

Common mitochondrial haplogroups as modifiers of the onset-age for critical COVID-19

E. Coto, E. Cuesta-Llavona, Daniel Vázquez-Coto, 2022, Mitochondrion.

Interactions between PPAR-α and inflammation-related cytokine genes on the development of Alzheimer's disease, observed by the Epistasis Project.

P. Deloukas, K. Morgan, K. Brown, 2012, International journal of molecular epidemiology and genetics.

Original Article Interactions between PPAR-α and inflammation-related cytokine genes on the development of Alzheimer's dis- ease, observed by the Epistasis Project

Erasmus Mc, K. Morgan, K. Brown, 2012 .

Amyloid Precursor Protein Gene (APP) Variation in Late-Onset Alzheimer’s Disease

V. Álvarez, E. Coto, C. Martínez, 2011, Journal of Molecular Neuroscience.

Open Access RESEARCH

V. Álvarez, E. Coto, R. Tarnawski, 2010 .

Angiotensin-converting enzyme and angiotensin II receptor 1 polymorphisms: association with early coronary disease.

V. Álvarez, E. Coto, A. Batalla, 1998, Cardiovascular research.

Lack of association between endothelin-1 gene variants and myocardial infarction.

V. Álvarez, E. Coto, F. Rodríguez-Pascual, 2009, Journal of atherosclerosis and thrombosis.

A Common APOE Polymorphism Is an Independent Risk Factor for Reduced Glomerular Filtration Rate in the Spanish RENASTUR Cohort

V. Álvarez, E. Coto, F. Ortega, 2013, Cardiorenal Medicine.

Role of serotonergic-related systems in suicidal behavior: Data from a case–control association study

J. Bobes, P. Corcoran, P. Sáiz, 2011, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Apolipoprotein E genotype and schizophrenia: further negative evidence

J. Bobes, V. Álvarez, E. Coto, 2002, Acta psychiatrica Scandinavica.

[Pharmacogenetics of angiotensin system in non diabetic nephropathy].

V. Álvarez, E. Coto, J. Campistol, 2005, Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.

Genetic variation in the renin-angiotensin system and athletic performance

Nicolás Terrados, V. Álvarez, E. Coto, 2000, European Journal of Applied Physiology.

Genetic Variation in the H19-IGF2 Cluster Might Confer Risk of Developing Impaired Renal Function.

E. Coto, H. Gil-Peña, P. Coto-Segura, 2018, DNA and cell biology.

Effect of the FTO rs9930506 Polymorphism on the Main Comorbidities of the Cardiorenal Metabolic Syndrome in an Elderly Spanish Cohort

E. Coto, B. Tavira, S. Tranche, 2014, Cardiorenal Medicine.

Emergence of New SARS-CoV2 Omicron Variants after the Change of Surveillance and Control Strategy

E. Coto, Z. Pérez-Martínez, M. Álvarez-Argüelles, 2022, Microorganisms.

Factor V Leiden (R506Q) and risk of venous thromboembolism: a case‐control study based on the Spanish population

V. Álvarez, E. Coto, C. López-Larrea, 1997, Clinical genetics.

Clinical Implications and Gender Differences of KCNQ1 p.Gly168Arg Pathogenic Variant in Long QT Syndrome

E. Coto, P. Avanzas, I. Pascual, 2020, Journal of clinical medicine.

Spectral Analysis of the QT Interval Increases the Prediction Accuracy of Clinical Variables in Brugada Syndrome

E. Coto, D. Calvo, J. Rubín, 2019, Journal of clinical medicine.

Time-dependent responses to provocative testing with flecainide in the diagnosis of Brugada syndrome.

E. Coto, J. M. García-Ruíz, D. Calvo, 2015, Heart rhythm.

MAPT H1 Haplotype is Associated with Late-Onset Alzheimer's Disease Risk in APOEɛ4 Noncarriers: Results from the Dementia Genetics Spanish Consortium.

J. Kulisevsky, O. Combarros, M. Bullido, 2015, Journal of Alzheimer's disease : JAD.

The sex-specific associations of the aromatase gene with Alzheimer’s disease and its interaction with IL10 in the Epistasis Project

P. Deloukas, K. Morgan, K. Brown, 2013, European Journal of Human Genetics.

ABCA1 polymorphisms and prognosis after myocardial infarction in young patients.

E. Coto, A. Batalla, C. Morís, 2006, International Journal of Cardiology.

Psoriasis, psoriatic arthritis and type 2 diabetes mellitus: a systematic review and meta‐analysis

E. Coto, R. Queiro-Silva, P. Coto-Segura, 2013, The British journal of dermatology.

Age-dependent effect of the IFIH1/MDA5 gene variants on the risk of critical COVID-19

V. Álvarez, E. Coto, E. Cuesta-Llavona, 2022, Immunogenetics.

The Ups and Downs of Genetic Diagnosis of Hypertrophic Cardiomyopathy.

E. Coto, J. Reguero, Juan Gómez, 2016, Revista espanola de cardiologia.

Gitelman syndrome in Gypsy paediatric patients carrying the same intron 9 + 1 G>T mutation. Clinical features and impact on quality of life.

V. Álvarez, E. Coto, H. Gil-Peña, 2011, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Mutation study of Spanish patients with hereditary hemorrhagic telangiectasia and expression analysis of Endoglin and ALK1

E. Coto, Africa Fernández-L, C. Restrepo, 2006, Human mutation.

Association between the TNFalpha-308 A/G polymorphism and the onset-age of Alzheimer disease.

V. Álvarez, E. Coto, I. Mata, 2002, American journal of medical genetics.

The Epistasis Project: A Multi-Cohort Study of the Effects of BDNF, DBH, and SORT1 Epistasis on Alzheimer's Disease Risk.

K. Morgan, A. Smith, P. Kehoe, 2019, Journal of Alzheimer's disease : JAD.

A physical map of two clusters containing the genes for six proinflammatory receptors

F. Setién, V. Álvarez, E. Coto, 1994, Immunogenetics.

Hypertrophic cardiomyopathy linked to homozygosity for a new mutation in the myosin-binding protein C gene (A627V) suggests a dosage effect.

V. Álvarez, E. Coto, A. Batalla, 2005, International journal of cardiology.

Association between Heroin Dependence and 5-HT2A Receptor Gene Polymorphisms

J. Bobes, P. Sáiz, C. Arango, 2008, European Addiction Research.

Mitochondrial DNA haplogroups in Spanish patients with hypertrophic cardiomyopathy.

V. Álvarez, E. Coto, V. Nunes, 2006, International journal of cardiology.

The G263X MYBPC3 mutation is a common and low-penetrant mutation for hypertrophic cardiomyopathy in the region of Asturias (Northern Spain).

V. Álvarez, E. Coto, María Martín, 2013, International journal of cardiology.

[Magnesium homeostasis. Etiopathogeny, clinical diagnosis and treatment of hypomagnesaemia. A case study].

E. Coto, F. Santos, E. P. González, 2009, Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.

Assessing the role of TUBA4A gene in frontotemporal degeneration

O. Combarros, V. Álvarez, J. Clarimón, 2016, Neurobiology of Aging.

Recessive hyperekplexia due to a new mutation (R100H) in the GLRA1 gene

V. Álvarez, E. Coto, Raúl Espinosa, 2005, Movement disorders : official journal of the Movement Disorder Society.

Identification of two new missense mutations (K58N and R121Q) in the Norrie disease (ND) gene in two Spanish families.

X. Estivill, E. Coto, V. Volpini, 1993, Human molecular genetics.

Mitochondrial DNA polymorphisms and risk of Parkinson's disease in Spanish population

V. Álvarez, E. Coto, M. Blázquez, 2005, Journal of the Neurological Sciences.

The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project

P. Deloukas, R. Gwilliam, C. Duijn, 2010, BMC Medical Genetics.

Variation in the lipoprotein receptor-related protein, α2-macroglobulin and lipoprotein receptor-associatedprotein genes in relation to plasma lipid levels and riskof early myocardial infarction

V. Álvarez, E. Coto, A. Batalla, 2002, Coronary artery disease.

Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer’s disease

P. Bosco, S. Kochen, F. Jessen, 2019, Translational Psychiatry.

No association between Parkinson's disease and three polymorphisms in the eNOS, nNOS, and iNOS genes

V. Álvarez, E. Coto, M. Blázquez, 2007, Neuroscience Letters.

P53 allelic loss and outcome in patients with squamous cell carcinoma of the head and neck

E. Coto, J. Rodrigo, C. Suárez, 2001, European Archives of Oto-Rhino-Laryngology.

Lack of association between protocadherin 11-X/Y (PCDH11X and PCDH11Y) polymorphisms and late onset Alzheimer's disease

V. Álvarez, E. Coto, C. Martínez, 2011, Brain Research.

5-Hydroxytryptamine 5-HT2A receptor and 5-hydroxytryptamine transporter polymorphisms in acute myocardial infarction.

V. Álvarez, E. Coto, A. Batalla, 2003, Clinical science.

FGF20 rs12720208 SNP and microRNA-433 variation: No association with Parkinson's disease in Spanish patients

V. Álvarez, E. Coto, B. Alonso, 2010, Neuroscience Letters.

A family with a milder form of adult dominant polycystic kidney disease not linked to the PKD1 (16p) or PKD2 (4q) genes.

V. Álvarez, E. Coto, M. Ariza, 1997, Journal of medical genetics.

Location of mutations within the PKD2 gene influences clinical outcome.

D Ravine, M Krawczak, M. Krawczak, 2000, Kidney international.

Aberrant splicing in the PKD2 gene as a cause of polycystic kidney disease.

R. Fossdal, E. Coto, G. Germino, 1999, Journal of the American Society of Nephrology : JASN.

Mitochondrial DNA haplogroups and risk of new-onset diabetes among tacrolimus-treated renal transplanted patients.

E. Coto, E. Ruiz-Pesini, L. Llobet, 2014, Gene.

Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus.

V. Álvarez, E. Coto, A. Ortiz, 2012, Molecular genetics and metabolism.

Association between the IL17RA rs4819554 polymorphism and reduced renal filtration rate in the Spanish RENASTUR cohort.

E. Coto, A. Ortiz, P. Coto-Segura, 2015, Human immunology.

Lack of association between protocadherin 11-X/Y (PCDH11X and PCDH11Y) polymorphisms and late onset Alzheimer's disease

V. Álvarez, E. Coto, C. Martínez, 2011, Brain Research.

Replication of MAPT and SNCA, but not PARK16‐18, as susceptibility genes for Parkinson's disease

O. Combarros, V. Álvarez, E. Coto, 2011, Movement disorders : official journal of the Movement Disorder Society.

A Search for SNCA 3′ UTR Variants Identified SNP rs356165 as a Determinant of Disease Risk and Onset Age in Parkinson’s Disease

V. Álvarez, E. Coto, P. Pástor, 2012, Journal of Molecular Neuroscience.

Lack of association between SNPsrs8176719 (O blood group) and COVID‐19: Data from Spanish age matched patients and controls

E. Coto, Juan Gómez, G. Albaiceta, 2020, Transfusion.

Common and rare CARD14 gene variants affect the antitumour necrosis factor response among patients with psoriasis

E. Coto, J. Gómez, P. Coto-Segura, 2016, The British journal of dermatology.

CDKAL1 gene variants affect the anti-TNF response among Psoriasis patients.

E. Coto, P. Coto-Segura, J. Santos-Juanes, 2015, International immunopharmacology.

Association study of the interleukin-1 gene complex and tumor necrosis factor alpha gene with suicide attempts

J. Bobes, P. Sáiz, C. Arango, 2008, Psychiatric genetics.

Mitochondrial DNA and TFAM gene variation in early-onset myocardial infarction: evidence for an association to haplogroup H.

V. Álvarez, E. Coto, A. Batalla, 2011, Mitochondrion.

DNA microsatellite analysis of families with autosomal dominant polycystic kidney disease types 1 and 2: evaluation of clinical heterogeneity between both forms of the disease.

E. Coto, C. López-Larrea, S. Sanz de Castro, 1995, Journal of medical genetics.

Cardiovascular risk factors influence response to biological therapies in psoriasis.

E. Coto, R. Queiro-Silva, P. Coto-Segura, 2015, Journal of the American Academy of Dermatology.

Profile of microRNAs in the plasma of hypertrophic cardiomyopathy patients compared to healthy controls.

V. Álvarez, E. Coto, C. Morís, 2013, International journal of cardiology.

New polymorphisms in human MEF2C gene as potential modifier of hypertrophic cardiomyopathy

E. Coto, J. Cannata-Andía, J. Fernández-Martín, 2012, Molecular Biology Reports.

Mitochondrial Heteroplasmy as a Marker for Premature Coronary Artery Disease: Analysis of the Poly-C Tract of the Control Region Sequence

E. Coto, P. Avanzas, I. Pascual, 2023, Journal of clinical medicine.

Interaction of insulin and PPAR-α genes in Alzheimer’s disease: the Epistasis Project

P. Deloukas, W. Maier, K. Morgan, 2012, Journal of Neural Transmission.

Pharmacogenetics of tacrolimus after renal transplantation: analysis of polymorphisms in genes encoding 16 drug metabolizing enzymes

V. Álvarez, E. Coto, R. Selgas, 2011 .

A new SLC12A3 founder mutation (p.Val647Met) in Gitelman's syndrome patients of Roma ancestry.

E. Coto, H. Gil-Peña, R. Vargas-Poussou, 2017, Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.

A labor- and cost-effective non-optical semiconductor (Ion Torrent) next-generation sequencing of the SLC12A3 and CLCNKA/B genes in Gitelman’s syndrome patients

V. Álvarez, E. Coto, F. Santos, 2014, Journal of Human Genetics.

Clinical and Analytical Findings in Gitelman’s Syndrome Associated with Homozygosity for the c.1925 G>A SLC12A3 Mutation

V. Álvarez, E. Coto, M. García-Castro, 2009, American Journal of Nephrology.

Molecular evolution of the N-formyl peptide and C5a receptors in non-human primates

F. Setién, V. Álvarez, E. Coto, 2007, Immunogenetics.

ABCB1 (MDR-1) pharmacogenetics of tacrolimus in renal transplanted patients: a Next Generation Sequencing approach

E. Coto, M. Arias, C. López-Larrea, 2015, Clinical chemistry and laboratory medicine.

Gly111Ser mutation in CD8A gene causing CD8 immunodeficiency is found in Spanish Gypsies.

J. Bertranpetit, E. Coto, L. Kalaydjieva, 2008, Molecular immunology.

Apolipoprotein ε4 allele is associated with Psoriasis severity: reply

V. Álvarez, E. Coto, P. Coto-Segura, 2010, Archives of Dermatological Research.

Rare genetic variants in GATA transcription factors in patients with hypertrophic cardiomyopathy

E. Coto, J. Cannata-Andía, María Martín, 2017, Journal of Investigative Medicine.

A search for new CYP3A4 variants as determinants of tacrolimus dose requirements in renal-transplanted patients.

V. Álvarez, E. Coto, C. López-Larrea, 2013, Pharmacogenetics & Genomics.

HLA antigens in psoriatic arthritis subtypes of a Spanish population.

E. Coto, C. López-Larrea, J. C. Torre Alonso, 1990, Annals of the rheumatic diseases.

HLA antigens inpsoriatic arthritis subtypes ofa Spanish population

E. Coto, C. López-Larrea, J. C. Torre-Alonso, 1990 .

Chromosome Y Haplogroup R Was Associated with the Risk of Premature Myocardial Infarction with ST-Elevation: Data from the CholeSTEMI Registry

E. Coto, P. Avanzas, I. Pascual, 2023, Journal of clinical medicine.

Gitelman syndrome: a review of clinical features, genetic diagnosis and therapeutic management

E. Coto, F. Santos, H. Gil-Peña, 2016 .

Compound heterozygosity for PTPN11 variants in a subject with Noonan syndrome provides insights into the mechanism of SHP2‐related disorders

E. Coto, M. Tartaglia, G. Bocchinfuso, 2020, Clinical genetics.

The Gitelman syndrome mutation, IVS9+1G>T, is common across Europe.

E. Coto, L. Kalaydjieva, D. Chandler, 2007, Kidney International.

KCNH2 p.Gly262AlafsTer98: A New Threatening Variant Associated with Long QT Syndrome in a Spanish Cohort

E. Coto, J. Rubín, I. Pascual, 2022, Life.

Negative evidences in association between apolipoprotein E polymorphism and panic disorder

J. Bobes, P. Sáiz, V. Álvarez, 2006, European Psychiatry.

Mitochondrial DNA Poly-C length heteroplasmy as a marker for risk of critical COVID-19

E. Coto, Daniel Vázquez-Coto, L. Amado-Rodríguez, 2023 .

Diagnostic impact of genetic testing in hypertrophic cardiomyopathy: The story of two families.

E. Coto, María Martín, C. Morís, 2016, International journal of cardiology.

Mapping the human genetic architecture of COVID-19

Eurie L. Hong, E. F. Perez, Rachel G Liao, 2021 .

HLA antigens in multiple sclerosis of northern Spanish population.

E. Coto, C. López-Larrea, D. Uría, 1990, Journal of neurology, neurosurgery, and psychiatry.

Spectrum of Mutations in Hypertrophic Cardiomyopathy Genes Among Tunisian Patients.

E. Coto, S. Kachboura, I. Kammoun, 2016, Genetic testing and molecular biomarkers.

Prothrombotic genetic risk factors and myocardial infarction at young age.

E. Coto, A. Batalla, J. Reguero, 1999, Blood.

N-acetyltransferase-2, glutathione S-transferase M1, alcohol dehydrogenase, and cytochrome P450IIE1 genotypes in alcoholic liver cirrhosis: a case-control study.

V. Álvarez, E. Coto, L. Rodrigo, 1999, Scandinavian journal of gastroenterology.

[Frequency of the APOE-4 allele in Alzheimer's disease and its variation with age in Asturias (Spain)].

V. Álvarez, E. Coto, J. Salas-Puig, 1999, Medicina clínica (Ed. impresa).

The Sp1/Egr1-tandem Repeat Polymorphism in the 5-Lipoxygenase Gene Promoter is not Associated With Late Onset Alzheimer Disease

V. Álvarez, E. Coto, C. Lahoz, 2008, Alzheimer disease and associated disorders.

Next generation sequencing search for uromodulin gene variants related with impaired renal function

E. Coto, S. Tranche, B. Alonso, 2015, Molecular Biology Reports.

Capillary Electrophoresis of PCR fragments with 5’-labelled primers for testing the SARS-Cov-2

V. Álvarez, E. Coto, E. Cuesta-Llavona, 2020, bioRxiv.

Capillary electrophoresis of PCR fragments with 5´-labelled primers for testing the SARS-Cov-2

V. Álvarez, E. Coto, E. Cuesta-Llavona, 2020, Journal of Virological Methods.

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Genetic, Nick C Fox, Michelle K. Lupton, 2019, Nature Genetics.

Role of serotonergic-related systems in suicidal behavior: Data from a case–control association study

J. Bobes, P. Corcoran, P. Sáiz, 2011, Progress in Neuro-psychopharmacology and Biological Psychiatry.

Mitochondrial DNA and TFAM gene variation in early-onset myocardial infarction: evidence for an association to haplogroup H.

V. Álvarez, E. Coto, A. Batalla, 2011, Mitochondrion.

KCNQ1 gene variants in the risk for type 2 diabetes and impaired renal function in the Spanish Renastur cohort

V. Álvarez, E. Coto, E. Delgado, 2016, Molecular and Cellular Endocrinology.

Pharmacogenetics of Calcineurin Inhibitors in Renal Transplantation

E. Coto, B. Tavira, 2009, Transplantation.

Hypertrophic cardiomyopathy and athlete's heart: a tale of two entities.

E. Coto, A. Carro, D. Calvo, 2009, European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology.

Diagnostic impact of genetic testing in hypertrophic cardiomyopathy: The story of two families.

E. Coto, María Martín, C. Morís, 2016, International journal of cardiology.

Differential role of serotonergic polymorphisms in alcohol and heroin dependence

J. Bobes, P. Corcoran, P. Sáiz, 2009, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Primary distal renal tubular acidosis: novel findings in patients studied by next-generation sequencing

E. Coto, F. Santos, H. Gil-Peña, 2018, Pediatric Research.

Association between a MYH9 polymorphism (rs3752462) and renal function in the Spanish RENASTUR cohort.

V. Álvarez, E. Coto, F. Ortega, 2013, Gene.

A CLCNKA polymorphism (rs10927887; p.Arg83Gly) previously linked to heart failure is associated with the estimated glomerular filtration rate in the RENASTUR cohort.

M. Sánchez-Niño, E. Coto, A. Ortiz, 2013, Gene.

Role of serotonergic polymorphisms in the clinical severity of the panic disorder

J. Bobes, P. Corcoran, P. Sáiz, 2009 .

Mutations in filamin C cause a new form of familial hypertrophic cardiomyopathy

X. Puente, R. Valdés-Mas, Diana A. Puente, 2014, Nature Communications.

Synergistic effect between apolipoprotein E and angiotensinogen gene polymorphisms in the risk for early myocardial infarction.

V. Álvarez, E. Coto, A. Batalla, 2000, Clinical chemistry.

The prothrombin 20210A allele and the factor V Leiden are associated with venous thrombosis but not with early coronary artery disease.

V. Álvarez, E. Coto, A. Batalla, 1999, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

MiRNA Profile in the Substantia Nigra of Parkinson’s Disease and Healthy Subjects

V. Álvarez, E. Coto, L. Cardo, 2014, Journal of Molecular Neuroscience.

The Sp1/Egr1-tandem Repeat Polymorphism in the 5-Lipoxygenase Gene Promoter is not Associated With Late Onset Alzheimer Disease

V. Álvarez, E. Coto, C. Lahoz, 2008, Alzheimer disease and associated disorders.

Profile of microRNAs in the plasma of hypertrophic cardiomyopathy patients compared to healthy controls.

V. Álvarez, E. Coto, C. Morís, 2013, International journal of cardiology.

Polymorphisms of the IL-1 gene complex are associated with alcohol dependence in Spanish Caucasians: data from an association study.

J. Leza, J. Bobes, P. Corcoran, 2009, Alcoholism, clinical and experimental research.

Genetic polymorphisms in the dopamine-2 receptor (DRD2), dopamine-3 receptor (DRD3), and dopamine transporter (SLC6A3) genes in schizophrenia: Data from an association study

L. Fañanás, J. Bobes, P. Corcoran, 2010, Progress in Neuro-Psychopharmacology and Biological Psychiatry.