Xin Chen

发表

Gene expression patterns in human liver cancers.

D. Botstein, P. Brown, S. Dudoit, 2002, Molecular biology of the cell.

Apigenin Enhanced Antitumor Effect of Cisplatin in Lung Cancer via Inhibition of Cancer Stem Cells

Xin Chen, Yunxia Li, Wei He, 2020, Nutrition and cancer.

Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations.

J. Zucman‐Rossi, D. Calvisi, Xin Chen, 2019, Cell metabolism.

Decoding global gene expression programs in liver cancer by noninvasive imaging

Howard Y. Chang, E. Segal, M. Kuo, 2007, Nature Biotechnology.

A genetic isolate of congenital lipoid adrenal hyperplasia with atypical clinical findings.

Xin Chen, W. Miller, B. Baker, 2005, The Journal of clinical endocrinology and metabolism.

Novel endothelial cell markers in hepatocellular carcinoma

M. Rijn, Xin Chen, S. Cheung, 2004, Modern Pathology.

Comparison of array-based comparative genomic hybridization with gene expression-based regional expression biases to identify genetic abnormalities in hepatocellular carcinoma

Karl J. Dykema, K. Dykema, K. Furge, 2005, BMC Genomics.

Radiogenomic analysis to identify imaging phenotypes associated with drug response gene expression programs in hepatocellular carcinoma.

M. Kuo, C. Sirlin, Xin Chen, 2007, Journal of vascular and interventional radiology : JVIR.

The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.

T. Fan, R. Higashi, Youngho Seo, 2012, Cell metabolism.

Potential role of O‐GlcNAcylation and involvement of PI3K/Akt1 pathway in the expression of oncogenic phenotypes of gastric cancer cells in vitro

Xin Chen, Nuobei Zhang, 2016, Biotechnology and applied biochemistry.

Reduced expression of EphB2 that parallels invasion and metastasis in colorectal tumours.

Jiafu Ji, Suet Yi Leung, Xin Chen, 2006, Carcinogenesis.

Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma.

Frank Bergmann, Matthias Evert, Kai Breuhahn, 2013, Gastroenterology.

An integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinoma

Rui Li, Chih-Jian Lih, Samuel So, 2005, Oncogene.

Cholangiocarcinomas can originate from hepatocytes in mice.

G. Gores, D. Calvisi, Xin Chen, 2012, The Journal of clinical investigation.

A microarray analysis of the emergence of embryonic definitive hematopoiesis.

J. Thomson, C. Kendziorski, Xin Chen, 2007, Experimental hematology.

SCD1 Expression Is Dispensable for Hepatocarcinogenesis Induced by AKT and Ras Oncogenes in Mice

D. Calvisi, Xin Chen, M. Evert, 2013, PloS one.

Role of the Notch signaling in cholangiocarcinoma

D. Calvisi, Xin Chen, A. Cigliano, 2017, Expert opinion on therapeutic targets.

Molecular profiling of intrahepatic cholangiocarcinoma: the search for new therapeutic targets

D. Calvisi, Xin Chen, J. Andersen, 2017, Expert review of gastroenterology & hepatology.

Harnessing big ‘omics’ data and AI for drug discovery in hepatocellular carcinoma

D. Calvisi, Xin Chen, R. Kelley, 2020, Nature Reviews Gastroenterology & Hepatology.

Targeting β‐catenin in hepatocellular cancers induced by coexpression of mutant β‐catenin and K‐Ras in mice

Xin Chen, J. Tao, Sucha Singh, 2017, Hepatology.

Efficacy of MEK inhibition in a K-Ras-driven cholangiocarcinoma preclinical model

D. Calvisi, Xin Chen, A. Cossu, 2018, Cell Death & Disease.

Crenigacestat, a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis

D. Calvisi, G. Giannelli, Xin Chen, 2020, Cell Death & Differentiation.

Monocytes promote liver carcinogenesis in an oncogene-specific manner.

K. Evason, Xin Chen, J. Bishop, 2016, Journal of hepatology.

Serum miRNAs as predictive and preventive biomarker for pre-clinical hepatocellular carcinoma.

G. Cao, Tangchun Wu, Hongyang Wang, 2016, Cancer letters.

Cabozantinib-based combination therapy for the treatment of hepatocellular carcinoma

D. Calvisi, Xin Chen, Meng Xu, 2020, Gut.

Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma

D. Calvisi, Xin Chen, S. Ribback, 2017, Cell cycle.

Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade

D. Calvisi, Xin Chen, A. Cigliano, 2017, PloS one.

Correlation of Exon 3 β-catenin Mutations with Glutamine Synthetase Staining Patterns in Hepatocellular Adenoma and Hepatocellular Carcinoma

S. Kakar, Xin Chen, R. Gill, 2016, Modern Pathology.

On the role of notch1 and adult hepatocytes in murine intrahepatic cholangiocarcinoma development

D. Calvisi, Xin Chen, S. Ribback, 2013, Hepatology.

IL‐33 facilitates oncogene‐induced cholangiocarcinoma in mice by an interleukin‐6‐sensitive mechanism

G. Gores, M. Borad, Xin Chen, 2015, Hepatology.

Inverse expression of Jun activation domain binding protein 1 and cell cycle inhibitor p27Kip1: influence on proliferation in hepatocellular carcinoma.

P. Schirmacher, T. Höller, Xin Chen, 2007, Human pathology.

Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

D. Calvisi, Xin Chen, S. Dupont, 2020, Communications Biology.

The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease

D. Calvisi, G. Giannelli, Xin Chen, 2022, Journal of Experimental & Clinical Cancer Research.

The Hippo effector TAZ cooperates with oncogenic β-catenin to induce hepatoblastoma development in mice and humans.

D. Calvisi, Xin Chen, J. Tao, 2020, The American journal of pathology.

The Hippo effector TAZ cooperates with oncogenic β-catenin in experimental and human hepatoblastoma development

J Zhang, D. Calvisi, Xin Chen, 2019 .

TEA Domain Transcription Factor 4 Is the Major Mediator of Yes-Associated Protein Oncogenic Activity in Mouse and Human Hepatoblastoma.

Pavel Sumazin, D. Calvisi, Xin Chen, 2019, The American journal of pathology.

Distinct role of nuclear receptor corepressor 1 regulated de novo fatty acids synthesis in liver regeneration and hepatocarcinogenesis in mice

Xin Chen, Hong-Yang Wang, F. Gonzalez, 2018, Hepatology.

Organoids for the Study of Liver Cancer diverse genetic landscape of alterations, including high degree of aneuploidy, DNA

D. Calvisi, Xin Chen, Haichuan Wang, 2021 .

Pivotal Role of Fatty Acid Synthase in c-MYC Driven Hepatocarcinogenesis

D. Calvisi, Xin Chen, S. Zhong, 2020, International journal of molecular sciences.

Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans.

D. Calvisi, Xin Chen, S. Ribback, 2016, Journal of hepatology.

mTORC2 Signaling is Required for Liver Regeneration in a Cholestatic Liver Injury Murine Model.

D. Calvisi, Xin Chen, Shumei Lin, 2020, The American journal of pathology.

mTORC2 signaling is necessary for timely liver regeneration after partial hepatectomy.

D. Calvisi, Xin Chen, Rong Li, 2020, The American journal of pathology.

Mammalian Target of Rapamycin Complex 2 Signaling Is Required for Liver Regeneration in a Cholestatic Liver Injury Murine Model

D. Calvisi, Xin Chen, Shumei Lin, 2020 .

[18F]-(2S,4R)4-Fluoroglutamine PET Imaging of Glutamine Metabolism in Murine Models of Hepatocellular Carcinoma (HCC)

Youngho Seo, Xin Chen, M. Yuneva, 2022, Molecular imaging.

A functional mTORC1 signaling is indispensable for c-Myc driven hepatocarcinogenesis

Ligong Chen, Xin Chen, A. Cossu, 2017 .

Both de novo synthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells

D. Calvisi, Xin Chen, S. Ribback, 2017, Liver international : official journal of the International Association for the Study of the Liver.

Therapeutic efficacy of FASN inhibition in preclinical models of HCC

D. Calvisi, Xin Chen, C. Sticht, 2022, Hepatology.

Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis

S. Kakar, Xin Chen, Chuanli Ren, 2018, Histopathology.

Podocalyxin-like protein 1 expression is useful to differentiate pancreatic ductal adenocarcinomas from adenocarcinomas of the biliary and gastrointestinal tracts.

Xin Chen, B. Sipos, R. Büttner, 2007, Human pathology.

Deregulated c-Myc requires a functional HSF1 for experimental and human hepatocarcinogenesis

D. Calvisi, Xin Chen, A. Cossu, 2017, Oncotarget.

Combined CDK4/6 and Pan-mTOR Inhibition Is Synergistic Against Intrahepatic Cholangiocarcinoma

D. Calvisi, Xin Chen, Hongbo Hu, 2018, Clinical Cancer Research.

CDK9 is dispensable for YAP‐driven hepatoblastoma development

D. Calvisi, Xin Chen, S. Zhong, 2020, Pediatric blood & cancer.

Central role of mTORC1 downstream of YAP/TAZ in hepatoblastoma development

D. Calvisi, Xin Chen, Pin Liu, 2017, Oncotarget.

The dark side of the moon: AKT as a tumor suppressor in the liver?

D. Calvisi, Xin Chen, 2016, Hepatology.

Crenigacestat blocking notch pathway reduces liver fibrosis in the surrounding ecosystem of intrahepatic CCA viaTGF-β inhibition

D. Calvisi, G. Giannelli, Xin Chen, 2022, Journal of Experimental & Clinical Cancer Research.

Harnessing big ‘omics’ data and AI for drug discovery in hepatocellular carcinoma

D. Calvisi, Xin Chen, R. Kelley, 2020, Nature Reviews Gastroenterology & Hepatology.

Hippo Cascade Controls Lineage Commitment of Liver Tumors in Mice and Humans.

D. Calvisi, Xin Chen, W. Cong, 2018, The American journal of pathology.

Organic cation transporters are determinants of oxaliplatin cytotoxicity.

Shuzhong Zhang, Takafumi Komori, Anna Lapuk, 2006, Cancer research.

Integration of DNA Copy Number Alterations and Transcriptional Expression Analysis in Human Gastric Cancer

Xin Chen, J. Ji, S. Leung, 2012, PloS one.

A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis

Li Ma, D. Xie, Jenny C. Chang, 2021, Nature Communications.

Hepatocellular carcinoma (HCC): the most promising therapeutic targets in the preclinical arena based on tumor biology characteristics

D. Calvisi, Xin Chen, Haichuan Wang, 2021, Expert opinion on therapeutic targets.

RASSF1A independence and early galectin‐1 upregulation in PIK3CA‐induced hepatocarcinogenesis: new therapeutic venues

D. Calvisi, Xin Chen, A. Teufel, 2021, bioRxiv.

Roles of microRNA in liver cancer

Xin Chen, J. Tao, Lili Jiang, 2018, Liver Research.

SKP2 cooperates with N-Ras or AKT to induce liver tumor development in mice

D. Calvisi, Xin Chen, S. Ribback, 2014, Oncotarget.

Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer

Jane Fridlyand, Xin Chen, J. Fridlyand, 2007, Hepatology.

Hedgehog signaling in human hepatocellular carcinoma

Xin Chen, S. Cheung, S. Fan, 2006, Cancer biology & therapy.

Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma.

Rui Li, Reinhard Büttner, Samuel So, 2005, Carcinogenesis.

Increased expression of glycosyl‐phosphatidylinositol anchor attachment protein 1 (GPAA1) is associated with gene amplification in hepatocellular carcinoma

Xin Chen, S. Cheung, S. Fan, 2006, International journal of cancer.

MicroRNA-494 Within an Oncogenic MicroRNA Megacluster Regulates G1/S Transition in Liver Tumorigenesis Through Suppression of Mutated in Colorectal Cancer

Aaron N. Chang, A. Balakrishnan, D. Brown, 2013, Hepatology.

MicroRNA‐21 and Dicer are dispensable for hepatic stellate cell activation and the development of liver fibrosis

R. Schwabe, P. Olinga, Xin Chen, 2018, Hepatology.

RNA interference as therapeutics for hepatocellular carcinoma.

Xin Chen, Susie A. Lee, Chuanrui Xu, 2011, Recent patents on anti-cancer drug discovery.

Mesenchymal cells of the intestinal lamina propria.

Xin Chen, D. Powell, R. Mifflin, 2011, Annual review of physiology.

New tools for functional genomic analysis.

Xin Chen, Eric Jorgenson, Xin Chen, 2009, Drug discovery today.

Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice

D. Calvisi, Xin Chen, J. Gordan, 2018, Oncogene.

Differential effects of targeting Notch receptors in a mouse model of liver cancer

Grégoire Pau, Xin Chen, D. French, 2015, Hepatology.

A positive feedback loop involving the LINC00346/β-catenin/MYC axis promotes hepatocellular carcinoma development

Xin Chen, Nuobei Zhang, 2020, Cellular Oncology.

Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans

M. Relling, P. Watkins, Xin Chen, 2006, Pharmacogenetics & Genomics.

Focal Adhesion Kinase (FAK) promotes cholangiocarcinoma development and progression via YAP activation.

R. Schwabe, D. Calvisi, Xin Chen, 2021, Journal of hepatology.

Chromosomal changes in fibrolamellar hepatocellular carcinoma detected by array comparative genomic hybridization

S. Kakar, D. Jain, Xin Chen, 2009, Modern Pathology.

A functional mammalian target of rapamycin complex 1 signaling is indispensable for c‐Myc‐driven hepatocarcinogenesis

D. Calvisi, Ligong Chen, Xin Chen, 2017, Hepatology.

Downregulation of lncRNA NEAT1_2 radiosensitizes hepatocellular carcinoma cells through regulation of miR‐101‐3p/WEE1 axis

Xin Chen, Nuobei Zhang, 2018, Cell biology international.

Inhibition of microRNA‐24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia

Xin Chen, C. Steer, H. Willenbring, 2014, Hepatology.

EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR‐dependent stabilization of MDM4 in hepatocellular carcinoma

P. Schirmacher, L. Zender, D. Calvisi, 2014, Hepatology.

Interferon–microRNA signalling drives liver precancerous lesion formation and hepatocarcinogenesis

Tao Zeng, Luonan Chen, Hongyang Wang, 2016, Gut.

Role of the Mammalian Target of Rapamycin Pathway in Liver Cancer: From Molecular Genetics to Targeted Therapies

D. Calvisi, Xin Chen, P. Paliogiannis, 2020, Hepatology.

Comprehensive analysis of 19q12 amplicon in human gastric cancers

Rui Li, I-Ping Tu, Kent-Man Chu, 2006, Modern Pathology.

Current challenges to underpinning the genetic basis for cholangiocarcinoma

D. Calvisi, Xin Chen, A. Cigliano, 2021, Expert review of gastroenterology & hepatology.

Oncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice.

Xin Chen, J. Ji, B. Fan, 2016, World journal of gastroenterology.

Distinct pathways of genomic progression to benign and malignant tumors of the liver

M. Kay, A. Tward, Xin Chen, 2007, Proceedings of the National Academy of Sciences.

Aldehyde dehydrogenase‐2 (ALDH2) opposes hepatocellular carcinoma progression by regulating AMP‐activated protein kinase signaling in mice

Lei Liu, Lei Chen, Yixue Li, 2017, Hepatology.

4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N‐Ras proto‐oncogenes in mice

Jeffrey W. Smith, D. Calvisi, Xin Chen, 2015, Hepatology.

Transcript AA454543 is a novel prognostic marker for hepatocellular carcinoma after curative partial hepatectomy.

Xin Chen, S. Cheung, S. So, 2005, Neoplasia.

Claudin-10 expression level is associated with recurrence of primary hepatocellular carcinoma.

Xin Chen, S. Cheung, S. So, 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities.

Darjus F. Tschaharganeh, D. Calvisi, Xin Chen, 2017, Cancer research.

Axis inhibition protein 1 (Axin1) Deletion–Induced Hepatocarcinogenesis Requires Intact β‐Catenin but Not Notch Cascade in Mice

D. Calvisi, Xin Chen, J. Tao, 2019, Hepatology.

Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer.

Xin Chen, S. So, S. Leung, 2004, Gastroenterology.

MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway

Xin Chen, C. Steer, Guisheng Song, 2015, Gut.

Granulin–Epithelin Precursor Overexpression Promotes Growth and Invasion of Hepatocellular Carcinoma

Xin Chen, S. Cheung, S. So, 2004, Clinical Cancer Research.

Bmi1 Is Required for Hepatic Progenitor Cell Expansion and Liver Tumor Development

D. Calvisi, Xin Chen, J. Tao, 2012, PloS one.

Bmi1 Functions as an Oncogene Independent of Ink4A/Arf Repression in Hepatic Carcinogenesis

Xin Chen, S. Cheung, Goberdhan P Dimri, 2009, Molecular Cancer Research.

Organoids for the Study of Liver Cancer

D. Calvisi, Xin Chen, Haichuan Wang, 2021, Seminars in Liver Disease.

Hydrodynamic transfection for generation of novel mouse models for liver cancer research.

D. Calvisi, Xin Chen, 2014, The American journal of pathology.

Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma

D. Calvisi, Xin Chen, A. Cigliano, 2019, Front. Oncol..

Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans

G. Gores, D. Calvisi, Xin Chen, 2016, Hepatology.

Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice

D. Calvisi, Xin Chen, S. Ribback, 2016, Scientific Reports.

Loss of Fbxw7 synergizes with activated AKT signaling to promote c-Myc dependent cholangiocarcinogenesis.

D. Calvisi, Xin Chen, A. Cossu, 2019, Journal of hepatology.

MicroRNA-206 prevents hepatosteatosis and hyperglycemia by facilitating insulin signaling and impairing lipogenesis

Xin Chen, C. Steer, Tianpeng Zhang, 2016, Journal of hepatology.

Loss of Apc cooperates with activated oncogenes to induce liver tumor formation in mice.

D. Calvisi, Xin Chen, M. Evert, 2021, The American journal of pathology.

Role of cyclin D1 as a mediator of c-Met- and beta-catenin-induced hepatocarcinogenesis.

Xin Chen, K. Jones, Susie A. Lee, 2009, Cancer research.

Aldehyde Dehydrogenase-2 (ALDH2) Opposes HCC Progression By Regulating AMPK Signaling.

Hongyang Wang, Lieping Chen, Xin Chen, 2016 .

Identify metastasis-associated genes in hepatocellular carcinoma through clonality delineation for multinodular tumor.

Xin Chen, S. Cheung, S. So, 2002, Cancer research.

Molecular Mechanisms of Hepatoblastoma

S. Cairo, D. Calvisi, Xin Chen, 2021, Seminars in Liver Disease.

Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse Hepatocarcinogenesis

D. Calvisi, Xin Chen, S. Ribback, 2020, Cellular and molecular gastroenterology and hepatology.

Focal adhesion kinase activation limits efficacy of Dasatinib in c‐Myc driven hepatocellular carcinoma

Jie Zhang, D. Calvisi, Xin Chen, 2018, Cancer medicine.

Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance

G. Gores, D. Calvisi, S. Vicent, 2023, Nature Reviews Gastroenterology & Hepatology.

TBX3 functions as a tumor suppressor downstream of activated CTNNB1 mutants during hepatocarcinogenesis.

D. Calvisi, Xin Chen, Shumei Lin, 2021, Journal of hepatology.

Nuclear factor erythroid 2–related factor 2 and β‐Catenin Coactivation in Hepatocellular Cancer: Biological and Therapeutic Implications

A. Bell, Xin Chen, J. Tao, 2021, Hepatology.

Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.

D. Calvisi, Xin Chen, Susie A. Lee, 2011, Gastroenterology.

MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment

D. Calvisi, Xiaosong Hu, Xin Chen, 2019, Cell Death & Disease.

A Noncoding Regulatory RNAs Network Driven by Circ‐CDYL Acts Specifically in the Early Stages Hepatocellular Carcinoma

Hongyang Wang, Xin Chen, P. Yang, 2020, Hepatology.

mTOR inhibition affects Yap1-β-catenin-induced hepatoblastoma growth and development

A. Bell, Xin Chen, Adeola O Adebayo Michael, 2019, Oncotarget.

The mTORC2‐Akt1 Cascade Is Crucial for c‐Myc to Promote Hepatocarcinogenesis in Mice and Humans

D. Calvisi, Xin Chen, Meng Xu, 2019, Hepatology.

Potential dual functional roles of the Y‐linked RBMY in hepatocarcinogenesis

Yun-Fai Chris Lau, Xin Chen, Z. Tabatabai, 2020, Cancer science.

MiR-429 increases the metastatic capability of HCC via regulating classic Wnt pathway rather than epithelial-mesenchymal transition.

Dan Cao, Shao Li, Lei Chen, 2015, Cancer letters.

Activation of β-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice.

D. Calvisi, Xin Chen, L. Terracciano, 2014, Gastroenterology.

Distinct functions of transforming growth factor-β signaling in c-MYC driven hepatocellular carcinoma initiation and progression

D. Calvisi, Xin Chen, Meng Xu, 2021, Cell Death & Disease.

Resveratrol reduces obesity in high-fat diet-fed mice via modulating the structure and metabolic function of the gut microbiota.

Xiaosong Hu, Xin Chen, Fang Chen, 2020, Free radical biology & medicine.

LncRNA FGD5-AS1 functions as an oncogene to upregulate GTPBP4 expression by sponging miR-873-5p in hepatocellular carcinoma

Xin Chen, Nuobei Zhang, Huifang Liu, 2021, European journal of histochemistry : EJH.

Crenigacestat, a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis

D. Calvisi, G. Giannelli, Xin Chen, 2020, Cell Death & Differentiation.

SNAI1 promotes the cholangiocellular phenotype, but not epithelial-mesenchymal transition, in a murine hepatocellular carcinoma model.

D. Calvisi, Xin Chen, Meng Xu, 2019, Cancer research.

Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver

D. Calvisi, J. Calderaro, Xin Chen, 2015, Oncotarget.

PI3K/AKT/mTOR‐dependent stabilization of oncogenic far‐upstream element binding proteins in hepatocellular carcinoma cells

S. Dooley, P. Schirmacher, D. Calvisi, 2016, Hepatology.

Circular RNAs regulate cancer stem cells by FMRP against CCAR1 complex in hepatocellular carcinoma

Xin Chen, R. Wu, Hong-Yang Wang, 2018, bioRxiv.

Oncogene-dependent function of BRG1 in hepatocarcinogenesis

Kairong Cui, K. Zhao, D. Calvisi, 2020, Cell Death & Disease.

Genetic and Epigenetic Regulation of the Organic Cation Transporter 3, SLC22A3

T. Ferrin, K. Giacomini, S. Yee, 2011, The Pharmacogenomics Journal.

β-Catenin signaling in hepatocellular carcinoma

D. Calvisi, Xin Chen, M. Evert, 2022, The Journal of clinical investigation.

Oncogenic potential of N-terminal deletion and S45Y mutant β-catenin in promoting hepatocellular carcinoma development in mice

D. Calvisi, Xin Chen, J. Tao, 2018, BMC Cancer.

Functional crosstalk between AKT/mTOR and Ras/MAPK pathways in hepatocarcinogenesis

D. Calvisi, Xin Chen, M. Evert, 2013, Cell cycle.

Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways.

D. Calvisi, Xin Chen, Susie A. Lee, 2012, Journal of hepatology.

AKT (v‐akt murine thymoma viral oncogene homolog 1) and N‐Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c‐Myc pathways

D. Calvisi, Xin Chen, Susie A. Lee, 2012, Hepatology.

Synergistic role of sprouty2 inactivation and c‐Met up‐regulation in mouse and human hepatocarcinogenesis

D. Calvisi, Xin Chen, Susie A. Lee, 2010, Hepatology.

Efficacy of MEK inhibition in a K-Ras-driven cholangiocarcinoma preclinical model

D. Calvisi, Xin Chen, A. Cossu, 2018, Cell Death & Disease.

Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans

D. Calvisi, Ligong Chen, Xin Chen, 2019, Gut.

Combined Treatment with MEK and mTOR Inhibitors is Effective in In Vitro and In Vivo Models of Hepatocellular Carcinoma

D. Calvisi, Xin Chen, Meng Xu, 2019, Cancers.

Role of Lipogenesis Rewiring in Hepatocellular Carcinoma

D. Calvisi, Xin Chen, J. Tao, 2021, Seminars in Liver Disease.

Chromosomal abnormalities determined by comparative genomic hybridization are helpful in the diagnosis of atypical hepatocellular neoplasms

S. Kakar, D. Jain, Xin Chen, 2009, Histopathology.

Overexpression of Mothers Against Decapentaplegic Homolog 7 Activates the Yes‐Associated Protein/NOTCH Cascade and Promotes Liver Carcinogenesis in Mice and Humans

D. Calvisi, Xin Chen, S. Ribback, 2021, Hepatology.

Functional role of SGK3 in PI3K/Pten driven liver tumor development

D. Calvisi, Xin Chen, S. Ribback, 2019, BMC Cancer.

Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway

D. Calvisi, Xin Chen, Meng Xu, 2018, Experimental & Molecular Medicine.

Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocar- cinoma induced in mice by AKT and Yap co-expression

D. Calvisi, G. Giannelli, Xin Chen, 2017 .

Activated mutant forms of PIK3CA cooperate with RasV12 or c‐Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade

D. Calvisi, Xin Chen, J. Tao, 2016, Liver international : official journal of the International Association for the Study of the Liver.

Hydrodynamic Injection for Developing NASH Model.

Xin Chen, Haichuan Wang, 2022, Methods in molecular biology.

Identifying strategies to target the metabolic flexibility of tumours

Xin Chen, N. Hay, P. Driscoll, 2020, Nature Metabolism.

Oncogene-dependent addiction to carbohydrate-responsive element binding protein in hepatocellular carcinoma

D. Calvisi, Xin Chen, S. Ribback, 2018, Cell cycle.

D. Calvisi, Xin Chen, S. Monga, 2019 .

Selective targeting of MYC mRNA by stabilized antisense oligonucleotides

Linda T. Nieman, Christopher J. Ott, Daniel G. Anderson, 2021, Oncogene.

Dual regulation of HMGB1 by combined JNK1/2–ATF2 axis with miR‐200 family in nonalcoholic steatohepatitis in mice

Hongyang Wang, Xin Chen, Jing Tang, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Crenigacestat blocking notch pathway reduces liver fibrosis in the surrounding ecosystem of intrahepatic CCA viaTGF-β inhibition

D. Calvisi, G. Giannelli, Xin Chen, 2022, Journal of Experimental & Clinical Cancer Research.

Differential requirement of Hippo cascade during CTNNB1 or AXIN1 mutation‐driven hepatocarcinogenesis

D. Calvisi, Xin Chen, S. Monga, 2022, Hepatology.

Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point‐mutant β‐catenin

J. Zucman‐Rossi, Xin Chen, G. Couchy, 2016, Hepatology.

Distinct anti-oncogenic effect of various microRNAs in different mouse models of liver cancer

D. Calvisi, Xin Chen, Junfang Ji, 2015, Oncotarget.

Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development.

H. Clevers, Xin Chen, S. Leung, 2010, Gastroenterology.

TAZ is indispensable for c-MYC-induced hepatocarcinogenesis.

D. Calvisi, Xin Chen, Hong Wu, 2021, Journal of hepatology.

MicroRNA‐206 prevents the pathogenesis of hepatocellular carcinoma by modulating expression of met proto‐oncogene and cyclin‐dependent kinase 6 in mice

Xin Chen, C. Steer, J. Niu, 2017, Hepatology.

Oncogene-dependent function of BRG1 in hepatocarcinogenesis

Kairong Cui, K. Zhao, D. Calvisi, 2020, Cell Death and Disease.

Oncogenic potential of N-terminal deletion and S45Y mutant β-catenin in promoting hepatocellular carcinoma development in mice

D. Calvisi, Xin Chen, J. Tao, 2018, BMC Cancer.

Overexpression of Mothers Against Decapentaplegic Homolog 7 Activates the Yes‐Associated Protein/NOTCH Cascade and Promotes Liver Carcinogenesis in Mice and Humans

D. Calvisi, Xin Chen, S. Ribback, 2020, Hepatology.

4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N‐Ras proto‐oncogenes in mice

Jeffrey W. Smith, D. Calvisi, Xin Chen, 2015, Hepatology.

[11C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice

D. Calvisi, Youngho Seo, Xin Chen, 2016, Molecular Imaging and Biology.

Alpelisib combination treatment as novel targeted therapy against hepatocellular carcinoma

D. Calvisi, Xin Chen, Hongwei Xu, 2021, Cell Death & Disease.

MicroRNA-206 Prevents the Pathogenesis of Hepatocellular Carcinoma Via Modulating Expression of cMet and Cdk 6

Xin Chen, Xiaomei Wang, C. Steer, 2017 .

Inhibition of HSF1 suppresses the growth of hepatocarcinoma cell lines in vitro and AKT-driven hepatocarcinogenesis in mice.

D. Calvisi, Xin Chen, S. Ribback, 2017, Oncotarget.

Combined Treatment with MEK and mTOR Inhibitors is Effective in In Vitro and In Vivo Models of Hepatocellular Carcinoma

D. Calvisi, Xin Chen, Meng Xu, 2019, Cancers.

Jagged 1 is a major Notch ligand along cholangiocarcinoma development in mice and humans

D. Calvisi, Xin Chen, A. Cossu, 2016, Oncogenesis.

[11C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice

D. Calvisi, Youngho Seo, Xin Chen, 2016, Molecular Imaging and Biology.

Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans

G. Gores, D. Calvisi, Xin Chen, 2016, Hepatology.

The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.

T. Fan, R. Higashi, Youngho Seo, 2012, Cell metabolism.

D. Calvisi, Xin Chen, Coral Ho, 2012, Hepatology.

Aberrant fucosylation sustains the NOTCH and EGFR/NF-κB pathways and has a prognostic value in human intrahepatic cholangiocarcinoma

D. Calvisi, G. Giannelli, Xin Chen, 2023, Hepatology.

Chromosomal abnormalities determined by comparative genomic hybridization are helpful in the diagnosis of atypical hepatocellular neoplasms

S. Kakar, D. Jain, Xin Chen, 2009, Histopathology.

Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice.

D. Calvisi, G. Giannelli, Xin Chen, 2017, Journal of hepatology.

YAP Accelerates NOTCH Driven Cholangiocarcinogenesis via mTORC1 in Mice.

D. Calvisi, Xin Chen, Hongwei Xu, 2021, The American journal of pathology.

On the role of notch1 and adult hepatocytes in murine intrahepatic cholangiocarcinoma development

D. Calvisi, Xin Chen, S. Ribback, 2013, Hepatology.

MiR-429 increases the metastatic capability of HCC via regulating classic Wnt pathway rather than epithelial-mesenchymal transition.

Hongyang Wang, Shao Li, Xin Chen, 2015, Cancer letters.

SKP2 cooperates with N-Ras or AKT to induce liver tumor development in mice

D. Calvisi, Xin Chen, S. Ribback, 2014, Oncotarget.