G. Loots

G. Loots, Bryce T. McLelland, N. Collette, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Sostdc1 regulates natural killer cell maturation and cytotoxicity

G. Loots, D. Murugesh, Alberto J. Millan, 2018, bioRxiv.

Improving Bone Health by Optimizing the Anabolic Action of Wnt Inhibitor Multitargeting

G. Loots, A. Robling, D. C. Genetos, 2021, JBMR plus.

Preexisting Type 1 Diabetes Mellitus Blunts the Development of Posttraumatic Osteoarthritis

G. Loots, B. Christiansen, D. Murugesh, 2022, JBMR plus.

Parathyroid Hormone (PTH)–Induced Bone Gain Is Blunted in SOST Overexpressing and Deficient Mice

G. Loots, M. Kneissel, Hansjoerg Keller, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Interactions Between Diabetes Mellitus and Osteoarthritis: From Animal Studies to Clinical Data

G. Loots, N. Hum, Naiomy D. Rios-Arce, 2022, JBMR plus.

Vhl deficiency in osteocytes produces high bone mass and hematopoietic defects.

G. Loots, A. Robling, D. Murugesh, 2018, Bone.

Hypoxia decreases sclerostin expression and increases Wnt signaling in osteoblasts

G. Loots, D. Fyhrie, D. C. Genetos, 2010, Journal of cellular biochemistry.

Maternal exposure to an environmentally relevant dose of triclocarban results in perinatal exposure and potential alterations in offspring development in the mouse model

G. Loots, K. Turteltaub, B. Buchholz, 2017, PloS one.

Genetic evidence that SOST inhibits WNT signaling in the limb.

G. Loots, R. Harland, D. Murugesh, 2010, Developmental biology.

Control of the SOST Bone Enhancer by PTH Using MEF2 Transcription Factors

F. Natt, G. Loots, O. Leupin, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Human Variation in Short Regions Predisposed to Deep Evolutionary Conservation

I. Ovcharenko, G. Loots, 2010, Molecular biology and evolution.

IL-17A Increases Doxorubicin Efficacy in Triple Negative Breast Cancer

G. Loots, E. Wheeler, M. Coleman, 2022, Frontiers in oncology.

Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer’s Patches

G. Loots, B. Malissen, S. Halle, 2018, Front. Immunol..

Tissue-Specific Enhancers in the Human Genome

M. Nóbrega, L. Pennacchio, I. Ovcharenko, 2006 .

Synthetic antibacterial minerals: harnessing a natural geochemical reaction to combat antibiotic resistance

Keith D. Morrison, G. Loots, J. Wimpenny, 2022, Scientific Reports.

Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice

G. Loots, P. Ghosh, Wei He, 2019, International journal of molecular sciences.

Sostdc1 deficiency accelerates fracture healing by promoting the expansion of periosteal mesenchymal stem cells.

G. Loots, A. Robling, B. Christiansen, 2016, Bone.

Dose-dependent consequences of sub-chronic fentanyl exposure on neuron and glial co-cultures

G. Loots, C. A. Valdez, N. Fischer, 2022, Frontiers in Toxicology.

LPS‐Induced Inflammation Prior to Injury Exacerbates the Development of Post‐Traumatic Osteoarthritis in Mice

G. Loots, B. Christiansen, D. Murugesh, 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis

G. Loots, B. Christiansen, D. Murugesh, 2022, Frontiers in Immunology.

1α,25-dihydroxyvitamin D3 stimulates human SOST gene expression and sclerostin secretion

G. Loots, Dongqing Yang, L. B. Solomon, 2015, Molecular and Cellular Endocrinology.

Preaxial Polydactyly in Sost/Sostdc1 Double Knockouts

G. Loots, N. Collette, C. M. Yee, 2011 .

Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice.

M. Atkins, S. Byers, S. Dakshanamurthy, 2020, Gastroenterology.

Conditional Deletion of Sost in MSC‐Derived Lineages Identifies Specific Cell‐Type Contributions to Bone Mass and B‐Cell Development

G. Loots, A. Robling, D. Murugesh, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Differential bone adaptation to mechanical unloading and reloading in young, old, and osteocyte deficient mice.

G. Loots, G. Kazakia, B. Christiansen, 2022, Bone.

Bridging the gap: Compressing non-unions for proper cellular signaling

G. Loots, T. Smit, P. Kloen, 2022, Medical Hypotheses.

Comparative genomic tools for exploring the human genome.

G. Loots, I. Ovcharenko, 2003, Cold Spring Harbor symposia on quantitative biology.

The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells

E. Petricoin, S. Byers, G. Loots, 2019, Molecular Cancer Research.

Effect of Age and Cytoskeletal Elements on the Indentation-Dependent Mechanical Properties of Chondrocytes

G. Loots, N. Chahine, C. Blanchette, 2013, PloS one.

Extracellular matrix modulates T cell clearance of malignant cells in vitro.

G. Loots, W. Hynes, Wei He, 2022, Biomaterials.

Post-Traumatic Osteoarthritis Progression is Diminished by Early Mechanical Unloading and Anti-Inflammatory Treatment in Mice.

H. Bang, G. Loots, B. Christiansen, 2021, Osteoarthritis and cartilage.

Prostate cancer invasion and metastasis: insights from mining genomic data.

G. Loots, K. Kulp, Bryan D. Hudson, 2013, Briefings in functional genomics.

rVISTA 2.0: evolutionary analysis of transcription factor binding sites

Ivan Ovcharenko, Gabriela G. Loots, I. Ovcharenko, 2004, Nucleic Acids Res..

Global Gene Expression Analysis of Murine Limb Development

I. Ovcharenko, G. Loots, L. Taher, 2011, PloS one.

Targeted deletion of Sost distal enhancer increases bone formation and bone mass

G. Loots, R. Harland, N. Lane, 2012, Proceedings of the National Academy of Sciences.

Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease.

D. Ovcharenko, E. Rubin, G. Loots, 2005, Genome research.

ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes

Ivan Ovcharenko, Gabriela G. Loots, Marcelo A. Nobrega, 2004, Nucleic Acids Res..

Evolution and functional classification of vertebrate gene deserts.

Webb Miller, Ivan Ovcharenko, Ross C Hardison, 2005, Genome research.

Cancer–Osteoblast Interaction Reduces Sost Expression in Osteoblasts and Up-Regulates lncRNA MALAT1 in Prostate Cancer

G. Loots, A. Sebastian, N. Hum, 2015, Microarrays.

Interpreting mammalian evolution using Fugu genome comparisons.

Ivan Ovcharenko, I. Ovcharenko, L. Stubbs, 2004, Genomics.

Global molecular changes in a tibial compression induced ACL rupture model of post‐traumatic osteoarthritis

G. Loots, B. Christiansen, A. Economides, 2016, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Antibiotic Treatment Prior to Injury Improves Post-Traumatic Osteoarthritis Outcomes in Mice

G. Loots, B. Christiansen, D. Murugesh, 2020, International journal of molecular sciences.

Regional Control of Hairless versus Hair-Bearing Skin by Dkk2.

G. Loots, Dianqing Wu, S. Millar, 2018, Cell reports.

MAVS mediates a protective immune response in the brain to Rift Valley fever virus

G. Loots, Doris Lam, A. Sebastian, 2021, bioRxiv.

Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer

S. Byers, G. Loots, E. Wheeler, 2020, Cancers.

Comparative Molecular Analysis of Cancer Behavior Cultured In Vitro, In Vivo, and Ex Vivo

G. Loots, E. Wheeler, Wei He, 2020, Cancers.

Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science

G. Loots, K. Turteltaub, B. Buchholz, 2019, Toxics.

Manipulation of the Gut Microbiome Alters Acetaminophen Biodisposition in Mice

James B Thissen, G. Loots, D. Murugesh, 2020, Scientific Reports.

Characterization of putative Wnt3a-Inducible Enhancers

G. Loots, A. Sebastian, N. Hum, 2015 .

Optimization of a genomic editing system using CRISPR/Cas9-induced site-specific gene integration

G. Loots, N. Hum, Jillian L McCool Ms., 2016 .

Strategies for characterising cis-regulatory elements in Xenopus.

G. Loots, M. Khokha, 2005, Briefings in functional genomics & proteomics.

Osteogenic preconditioning in perfusion bioreactors improves vascularization and bone formation by human bone marrow aspirates

G. Loots, T. Gonzalez-Fernandez, J. K. Leach, 2020, Science Advances.

Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II–Induced Aortic Aneurysm and Atherosclerosis

G. Loots, J. Golledge, E. Biros, 2017, Arteriosclerosis, Thrombosis and Vascular Biology.

ECRbase: database of evolutionary conserved regions, promoters, and transcription factor binding sites in vertebrate genomes

Ivan Ovcharenko, Gabriela G. Loots, I. Ovcharenko, 2007, Bioinform..

Sclerostin Deficiency Alters Peripheral B Lymphocyte Responses in Mice

G. Loots, A. Economides, J. Manilay, 2018, bioRxiv.

Dcode.org anthology of comparative genomic tools

Ivan Ovcharenko, Gabriela G. Loots, I. Ovcharenko, 2005, Nucleic Acids Res..

UCRL-TR-228361 04-ERD-052-Final Report

I. Ovcharenko, L. Stubbs, G. Loots, 2007 .

Array2BIO: from microarray expression data to functional annotation of co-regulated genes

Ivan Ovcharenko, Gabriela G. Loots, Patrick S. G. Chain, 2006, BMC Bioinformatics.

Array2BIO: A Comprehensive Suite of Utilities for the Analysis of Microarray Data

I. Ovcharenko, G. Loots, S. Mabery, 2006 .

Expression of a Degradation‐Resistant β‐Catenin Mutant in Osteocytes Protects the Skeleton From Mechanodeprivation‐Induced Bone Wasting

G. Loots, A. Robling, M. Warman, 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Prostaglandin E2 Signals Through PTGER2 to Regulate Sclerostin Expression

Gabriela G. Loots, G. Loots, C. Yellowley, 2011, PloS one.

The use of nanolipoprotein particles to enhance the immunostimulatory properties of innate immune agonists against lethal influenza challenge

G. Loots, N. Fischer, A. Sant, 2013, Biomaterials.

TGF-β regulates sclerostin expression via the ECR5 enhancer.

G. Loots, D. Murugesh, O. Leupin, 2012, Bone.

Impact of the Xenopus system on the missions of the NHGRI

G. Loots, 2009 .

Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner☆

G. Loots, L. Taher, R. Harland, 2013, Developmental biology.

comparative sequence-based discovery of functional transcription factor binding sites

Lior Pachter, Inna Dubchak, Ivan Ovcharenko, 2002 .

Strategies for characterising cis-regulatory elements in

G. Loots, M. Khokha, S. Francisco, 2005 .

Modifying yeast artificial chromosomes to generate Cre/LoxP and FLP/FRT site-specific deletions and inversions.

G. Loots, 2006, Methods in molecular biology.

Transcriptional control of Sost in bone.

G. Loots, A. Sebastian, 2017, Bone.

Global Gene Expression Analysis Identifies Age-Related Differences in Knee Joint Transcriptome during the Development of Post-Traumatic Osteoarthritis in Mice

G. Loots, B. Christiansen, D. Murugesh, 2020, International journal of molecular sciences.

SOST Inhibits Prostate Cancer Invasion

G. Loots, B. Christiansen, M. Coleman, 2015, PloS one.

Gene Regulation in Van Buchem Disease

G. Loots, 2012 .

Sost, independent of the non-coding enhancer ECR5, is required for bone mechanoadaptation.

G. Loots, A. Robling, D. Murugesh, 2016, Bone.

SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury

G. Loots, B. Christiansen, A. Economides, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts

G. Loots, A. Economides, D. Murugesh, 2017, PloS one.

Lrp4 Mediates Bone Homeostasis and Mechanotransduction through Interaction with Sclerostin In Vivo

G. Loots, A. Robling, T. Bellido, 2019, iScience.

Interrogating Transcriptional Regulatory Sequences in Tol2-Mediated Xenopus Transgenics

I. Ovcharenko, G. Loots, R. Harland, 2013, PloS one.

SNPs in putative regulatory regions identified by human mouse comparative sequencing and transcription factor binding site data

T. Speed, I. Dubchak, E. Rubin, 2002, Mammalian Genome.

Single-Cell RNA-Seq Reveals Transcriptomic Heterogeneity and Post-Traumatic Osteoarthritis-Associated Early Molecular Changes in Mouse Articular Chondrocytes

G. Loots, B. Christiansen, D. Murugesh, 2021, Cells.

Electric Fields at Breast Cancer and Cancer Cell Collective Galvanotaxis

G. Loots, B. Reid, Min Zhao, 2020, Scientific Reports.

Global gene expression analysis identifies Mef2c as a potential player in Wnt16-mediated transcriptional regulation.

G. Loots, D. Murugesh, A. Sebastian, 2018, Gene.

Tracking Tumor Colonization in Xenograft Mouse Models Using Accelerator Mass Spectrometry

G. Loots, B. Buchholz, M. Malfatti, 2018, Scientific Reports.

Manipulation of the Gut Microbiome Alters Acetaminophen Biodisposition in Mice

James B Thissen, G. Loots, D. Murugesh, 2020, Scientific Reports.

Degradation‐Resistant Hypoxia Inducible Factor‐2α in Murine Osteocytes Promotes a High Bone Mass Phenotype

G. Loots, B. Christiansen, D. Murugesh, 2023, JBMR plus.

Transcriptional Profiling for Genetic Assessment

G. Loots, A. Sebastian, 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism.

Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and Progression

G. Loots, B. Christiansen, A. Economides, 2018, International journal of molecular sciences.

1 Comparative Transcriptomics Identifies Novel Genes 2 and Pathways Involved in Post-Traumatic Osteoarthritis 3 Development and Progression 4

G. Loots, B. Christiansen, A. Economides, 2018 .

Functional and transcriptional characterization of complex neuronal co-cultures

G. Loots, K. Kulp, E. Wheeler, 2020, Scientific Reports.

Sostdc1 Suppression in the Absence of Sclerostin Potentiates Anabolic Action of Cortical Bone in Mice

G. Loots, A. Robling, A. Hoggatt, 2023, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Nanocomposite scaffold for chondrocyte growth and cartilage tissue engineering: effects of carbon nanotube surface functionalization.

G. Loots, N. Chahine, Cynthia B. Thomas, 2014, Tissue engineering. Part A.

Antibiotic Treatment Prior to Injury Abrogates the Detrimental Effects of LPS in STR/ort Mice Susceptible to Osteoarthritis Development

G. Loots, B. Christiansen, Melanie E. Mendez, 2023, JBMR Plus.

Engineered bone marrow as a clinically relevant ex vivo model for primary bone cancer research and drug screening

G. Loots, S. Thorpe, A. Sebastian, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Synthetic antibacterial minerals: harnessing a natural geochemical reaction to combat antibiotic resistance

Keith D. Morrison, G. Loots, J. Wimpenny, 2022, Scientific Reports.

Sclerostin Depletion Induces Inflammation in the Bone Marrow of Mice

G. Loots, A. Robling, D. Murugesh, 2021, International journal of molecular sciences.

Sclerostin neutralization unleashes the osteoanabolic effects of Dkk1 inhibition.

G. Loots, A. Robling, K. Lim, 2018, JCI insight.

Transcriptional control of Sost in bone.

G. Loots, A. Sebastian, 2017, Bone.

rVISTA 2.0: evolutionary analysis of transcription factor binding sites

I. Ovcharenko, G. Loots, 2004, Nucleic Acids Res..

Coccidioidomycosis Osteoarticular Dissemination

G. Loots, D. Weilhammer, Benedicte M. Moni, 2023, Journal of fungi.

Altered canalicular remodeling associated with femur fracture in mice

G. Loots, B. Christiansen, T. Alliston, 2021, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

ECRbase: database of evolutionary conserved regions, promoters, and transcription factor binding sites in vertebrate genomes

I. Ovcharenko, G. Loots, 2007, Bioinform..

Loss of Cadherin-11 in pancreatic ductal adenocarcinoma alters tumor-immune microenvironment

G. Loots, A. Sebastian, Kelly A. Martin, 2023, Frontiers in oncology.

Host tracheal and intestinal microbiomes inhibit Coccidioides growth in vitro

G. Loots, D. Weilhammer, K. Hoyer, 2024, Microbiology spectrum.

Host tracheal and intestinal microbiomes inhibit Coccidioides growth in vitro

Suzanne S. Sindi, G. Loots, D. Weilhammer, 2023, bioRxiv.

How genomics is changing our view of cancer.

G. Loots, 2013, Briefings in functional genomics.

Mef2c regulates bone mass through Sost-dependent and -independent mechanisms.

G. Loots, B. Christiansen, D. Murugesh, 2023, Bone.

Conditional Deletion of Sost in MSC‐Derived Lineages Identifies Specific Cell‐Type Contributions to Bone Mass and B‐Cell Development

G. Loots, A. Robling, D. Murugesh, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.