I. Tinhofer

发表

Enhanced MTT-reducing activity under growth inhibition by resveratrol in CEM-C7H2 lymphocytic leukemia cells.

D. Bernhard, W. Schwaiger, R. Crazzolara, 2003, Cancer letters.

2D and 3D convolutional neural networks for outcome modelling of locally advanced head and neck squamous cell carcinoma

Sebastian Starke, Steffen Löck, Mechthild Krause, 2020, Scientific Reports.

Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition

I. Tinhofer, O. von Ahsen, T. Krahn, 2012, BMC Cancer.

Comprehensive Analysis of Tumour Sub-Volumes for Radiomic Risk Modelling in Locally Advanced HNSCC

I. Tinhofer, S. Leger, S. Löck, 2020, Cancers.

HPV in

V. Budach, J. Debus, A. Abdollahi, 2014 .

Pilot investigation on the dose-dependent impact of irradiation on primary human alveolar osteoblasts in vitro

I. Tinhofer, M. Heiland, R. Lauster, 2021, Scientific Reports.

Expression of functional interleukin-15 receptor and autocrine production of interleukin-15 as mechanisms of tumor propagation in multiple myeloma.

R. Greil, I. Tinhofer, T. Henn, 2000, Blood.

Support of a molecular tumour board by an evidence-based decision management system for precision oncology.

M. Yaspo, F. Klauschen, D. Lenze, 2020, European journal of cancer.

Fever range whole body hyperthermia for re-irradiation of head and neck squamous cell carcinomas: Final results of a prospective study.

P. Wust, V. Budach, I. Tinhofer, 2021, Oral oncology.

Development of CLL in the TCL1 transgenic mouse model is associated with severe skewing of the T-cell compartment homologous to human CLL

R. Greil, I. Tinhofer, T. Kocher, 2011, Leukemia.

Functional granulocyte/macrophage colony stimulating factor receptor is constitutively expressed on neoplastic plasma cells and mediates tumour cell longevity

R. Greil, I. Tinhofer, A. Villunger, 1998, British journal of haematology.

Primary Extracellular Matrix Enables Long-Term Cultivation of Human Tumor Oral Mucosa Models

I. Tinhofer, U. Keilholz, M. Schäfer-Korting, 2020, Frontiers in Bioengineering and Biotechnology.

Preclinical models of head and neck squamous cell carcinoma for a basic understanding of cancer biology and its translation into efficient therapies

I. Tinhofer, D. Braunholz, K. Klinghammer, 2020, Cancers of the Head & Neck.

The rationale for including immune checkpoint inhibition into multimodal primary treatment concepts of head and neck cancer

V. Budach, I. Tinhofer, U. Keilholz, 2016, Cancers of the Head & Neck.

Association of Epidermal Growth Factor Receptor Polymorphism, Skin Toxicity, and Outcome in Patients with Squamous Cell Carcinoma of the Head and Neck Receiving Cetuximab-Docetaxel Treatment

V. Budach, I. Tinhofer, U. Keilholz, 2009, Clinical Cancer Research.

Expression of Amphiregulin and EGFRvIII Affect Outcome of Patients with Squamous Cell Carcinoma of the Head and Neck Receiving Cetuximab–Docetaxel Treatment

W. Weichert, A. Stenzinger, V. Budach, 2011, Clinical Cancer Research.

68Ga-PSMA-PET/CT-based radiosurgery and stereotactic body radiotherapy for oligometastatic prostate cancer

I. Tinhofer, G. Kalinauskaite, C. Furth, 2020, PloS one.

Organ Preservation and Late Functional Outcome in Oropharyngeal Carcinoma: Rationale of EORTC 1420, the “Best of” Trial

V. Grégoire, I. Tinhofer, S. Quaglini, 2019, Front. Oncol..

Epithelial-mesenchymal-transition induced by EGFR activation interferes with cell migration and response to irradiation and cetuximab in head and neck cancer cells.

V. Budach, I. Tinhofer, L. Distel, 2011, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

A Novel 2-Metagene Signature to Identify High-Risk HNSCC Patients amongst Those Who Are Clinically at Intermediate Risk and Are Treated with PORT

V. Budach, A. Abdollahi, I. Tinhofer, 2022, Cancers.

Novel prognostic clinical factors and biomarkers for outcome prediction in head and neck cancer: a systematic review.

V. Budach, I. Tinhofer, 2019, The Lancet. Oncology.

Heat shock protein 70 and tumor‐infiltrating NK cells as prognostic indicators for patients with squamous cell carcinoma of the head and neck after radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK‐ROG)

V. Budach, J. Debus, A. Abdollahi, 2017, International journal of cancer.

Contribution of human papilloma virus to the incidence of squamous cell carcinoma of the head and neck in a European population with high smoking prevalence.

W. Weichert, A. Stenzinger, V. Budach, 2015, European journal of cancer.

Fludarabine modulates composition and function of the T cell pool in patients with chronic lymphocytic leukaemia

R. Greil, I. Tinhofer, R. Geisberger, 2010, Cancer Immunology, Immunotherapy.

A FDG-PET radiomics signature detects esophageal squamous cell carcinoma patients who do not benefit from chemoradiation

H. Amthauer, F. Hofheinz, V. Budach, 2020, Scientific Reports.

Combination of copanlisib with cetuximab improves tumor response in cetuximab-resistant patient-derived xenografts of head and neck cancer

I. Tinhofer, J. Hoffmann, J. Raguse, 2020, Oncotarget.

Tetrocarcin-A--induced ER stress mediates apoptosis in B-CLL cells via a Bcl-2--independent pathway.

R. Greil, I. Tinhofer, G. Anether, 2003, Blood.

Stressful death of T‐ALL tumor cells following treatment with the antitumor agent Tetrocarcin‐A

R. Greil, D. Bernhard, I. Tinhofer, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Biomarker signatures for primary radiochemotherapy of locally advanced HNSCC - hypothesis generation on a multicentre cohort of the DKTK-ROG.

I. Tinhofer, S. Löck, M. Krause, 2022, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Comparison of GeneChip, nCounter and real-time polymerase chain reaction based gene expressions predicting loco-regional tumour control after primary and postoperative radiochemotherapy in head and neck squamous cell carcinoma.

V. Budach, F. Buchholz, J. Debus, 2020, The Journal of molecular diagnostics : JMD.

SDF-1/CXCR4 expression is an independent negative prognostic biomarker in patients with head and neck cancer after primary radiochemotherapy.

V. Budach, J. Debus, A. Abdollahi, 2017, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Pifithrin-&agr; as a Potential Cytoprotective Agent in Radiotherapy: Protection of Normal Tissue without Decreasing Therapeutic Efficacy in Glioma Cells

V. Budach, I. Tinhofer, D. Freyer, 2010, Radiation research.

The presence of circulating tumor cells (CTCs) correlates with lymph node metastasis in nonresectable squamous cell carcinoma of the head and neck region (SCCHN).

W. Weichert, A. Stenzinger, V. Budach, 2011, Annals of oncology : official journal of the European Society for Medical Oncology.

Detection of circulating tumor cells for prediction of recurrence after adjuvant chemoradiation in locally advanced squamous cell carcinoma of the head and neck.

V. Budach, I. Tinhofer, J. Raguse, 2014, Annals of oncology : official journal of the European Society for Medical Oncology.

Multiparametric Phenotyping of Circulating Tumor Cells for Analysis of Therapeutic Targets, Oncogenic Signaling Pathways and DNA Repair Markers

P. Jank, I. Tinhofer, A. Hauser, 2022, Cancers.

Tracking death dealing by Fas and TRAIL in lymphatic neoplastic disorders: pathways, targets, and therapeutic tools

R. Greil, I. Tinhofer, Gabriele Anether, 2003, Journal of leukocyte biology.

Standard or split TPF induction chemotherapy followed by bioradiation: ICRAT randomized phase II study.

V. Budach, I. Tinhofer, S. Tribius, 2016 .

Tumor DNA‐methylome derived epigenetic fingerprint identifies HPV‐negative head and neck patients at risk for locoregional recurrence after postoperative radiochemotherapy

W. Weichert, V. Budach, A. Abdollahi, 2021, International journal of cancer.

Integration of p16/HPV DNA Status with a 24-miRNA-Defined Molecular Phenotype Improves Clinically Relevant Stratification of Head and Neck Cancer Patients

A. Walch, I. Tinhofer, M. Krause, 2022, Cancers.

Differential sensitivity of CD4+ and CD8+ T lymphocytes to the killing efficacy of Fas (Apo-1/CD95) ligand+ tumor cells in B chronic lymphocytic leukemia.

R. Greil, I. Tinhofer, A. Villunger, 1998, Blood.

Differential Sensitivity of CD 4 1 and CD 8 1 T Lymphocytes to the Killing Efficacy of Fas ( Apo-1 / CD 95 ) Ligand 1 Tumor Cells in B Chronic Lymphocytic Leukemia

R. Greil, I. Tinhofer, A. Villunger, 1998 .

The DKTK EXLIQUID consortium – exploiting liquid biopsies to advance cancer precision medicine for molecular tumor board patients

H. Sültmann, I. Tinhofer, C. Schroeder, 2022, LaboratoriumsMedizin.

PET measured hypoxia and MRI parameters in re-irradiated head and neck squamous cell carcinomas: findings of a prospective pilot study

H. Amthauer, F. Hofheinz, P. Wust, 2021, F1000Research.

PET measured hypoxia and MRI parameters in re-irradiated head and neck squamous cell carcinomas: findings of a prospective pilot study.

H. Amthauer, F. Hofheinz, P. Wust, 2020, F1000Research.

Synergistic action of protein kinase C θ and calcineurin is sufficient for Fas ligand expression and induction of a crmA‐sensitive apoptosis pathway in Jurkat T cells

R. Greil, D. Green, I. Tinhofer, 1999, European journal of immunology.

MDM2 SNP309 is associated with poor outcome in B-cell chronic lymphocytic leukemia.

R. Greil, I. Tinhofer, M. Steurer, 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Integrated radiogenomics analyses allow for subtype classification and improved outcome prognosis of patients with locally advanced HNSCC

I. Tinhofer, S. Löck, M. Krause, 2022, Scientific Reports.

Modifying akt signaling in B-cell chronic lymphocytic leukemia cells.

R. Greil, I. Tinhofer, Wei Wang, 2010, Cancer research.

ifying Akt Signaling in B-Cell Chronic R phocytic Leukemia Cells

R. Greil, I. Tinhofer, Wei Wang, 2010 .

Bcl-2-independent pathway Tetrocarcin-A-induced ER stress mediates apoptosis in B-CLL cells via a

R. Greil, I. Tinhofer, Gabriele Anether, 2013 .

Regulatory T cells predict the time to initial treatment in early stage chronic lymphocytic leukemia

R. Greil, I. Tinhofer, T. Melchardt, 2011, Cancer.

The effect of IgVH mutational status on the induction of apoptosis by rituximab in patients with heavily pretreated B-cell chronic lymphocytic leukemia: evidence from a clinical phase I/II trial.

R. Greil, I. Tinhofer, M. Steurer, 2006, Haematologica.

SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy

V. Budach, J. Debus, A. Abdollahi, 2017, Clinical and translational radiation oncology.

Interleukin-15 as a potential costimulatory cytokine in CD154 gene therapy of chronic lymphocytic leukemia.

R. Greil, I. Tinhofer, I. Marschitz, 2002, Blood.

SNP309 as predictor for sensitivity of CLL cells to the MDM2 inhibitor nutlin-3a.

R. Greil, I. Tinhofer, S. Hofbauer, 2008, Blood.

Analysis of Bcl-2 protein expression in chronic lymphocytic leukemia. A comparison of three semiquantitation techniques.

R. Greil, I. Tinhofer, A. Egle, 2000, American journal of clinical pathology.

PKCdelta is involved in signal attenuation in CD3+ T cells.

I. Tinhofer, G. Baier, M. Leitges, 2005, Immunology letters.

Establishment and Validation of CyberKnife Irradiation in a Syngeneic Glioblastoma Mouse Model

I. Tinhofer, P. Vajkoczy, A. Conti, 2021, Cancers.

Evaluation of prognostic factors after primary chemoradiotherapy of anal cancer: A multicenter study of the German Cancer Consortium - Radiation Oncology Group (DKTK-ROG).

V. Budach, I. Tinhofer, C. Belka, 2022, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

CD8+ tumour‐infiltrating lymphocytes in relation to HPV status and clinical outcome in patients with head and neck cancer after postoperative chemoradiotherapy: A multicentre study of the German cancer consortium radiation oncology group (DKTK‐ROG)

Mechthild Krause, Michael Baumann, Christine Bayer, 2016, International journal of cancer.

A role of TRAIL in killing osteoblasts by myeloma cells

R. Greil, R. Crazzolara, I. Tinhofer, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia.

R. Greil, I. Tinhofer, O. Merkel, 2010, Blood.

Spheroid Culture of Head and Neck Cancer Cells Reveals an Important Role of EGFR Signalling in Anchorage Independent Survival

V. Budach, I. Tinhofer, D. Braunholz, 2016, PloS one.

Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(−) HNSCC after Postoperative Radiochemotherapy: A Multicenter Study of the DKTK-ROG

D. Aust, V. Budach, F. Buchholz, 2016, Clinical Cancer Research.

The role of Next-Generation Sequencing in tumoral radiosensitivity prediction

J. Bibault, I. Tinhofer, 2017, Clinical and translational radiation oncology.

Next-generation sequencing: hype and hope for development of personalized radiation therapy?

W. Weichert, A. Stenzinger, V. Budach, 2015, Radiation Oncology.

Resveratrol causes arrest in the S-phase prior to Fas-independent apoptosis in CEM-C7H2 acute leukemia cells

R. Greil, D. Bernhard, I. Tinhofer, 2000, Cell Death and Differentiation.

Methylation of RAD51B, XRCC3 and other homologous recombination genes is associated with expression of immune checkpoints and an inflammatory signature in squamous cell carcinoma of the head and neck, lung and cervix

F. Klauschen, I. Tinhofer, T. Seiwert, 2016, Oncotarget.

Interference of tumour mutational burden with outcome of patients with head and neck cancer treated with definitive chemoradiation: a multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group.

V. Budach, J. Debus, A. Abdollahi, 2019, European journal of cancer.

Epithelial-to-mesenchymal transition and cancer stem(-like) cells in head and neck squamous cell carcinoma.

I. Tinhofer, A. Kaufmann, A. Albers, 2013, Cancer letters.

Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition

I. Tinhofer, T. Krahn, T. Zollner, 2012, BMC Cancer.

Multilayered Omics-Based Analysis of a Head and Neck Cancer Model of Cisplatin Resistance Reveals Intratumoral Heterogeneity and Treatment-Induced Clonal Selection

F. Klauschen, V. Budach, I. Tinhofer, 2017, Clinical Cancer Research.

Distinct immune evasion in APOBEC‐enriched, HPV‐negative HNSCC

S. Fröhling, B. Obermayer, W. Weichert, 2020, International journal of cancer.

Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCC

S. Fröhling, B. Obermayer, W. Weichert, 2019, bioRxiv.

A phase II study of monalizumab in patients with recurrent/metastatic squamous cell carcinoma of the head and neck: The I1 cohort of the EORTC-HNCG-1559 UPSTREAM trial.

J. Machiels, I. Tinhofer, J. Canon, 2021, European journal of cancer.

Prognostic Factors Predict Oncological Outcome in Older Patients With Head and Neck Cancer Undergoing Chemoradiation Treatment

I. Tinhofer, M. Heiland, G. Kalinauskaite, 2021, Frontiers in Oncology.

Resveratrol, a tumor‐suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl‐2

R. Greil, G. Kroemer, D. Bernhard, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells

R. Greil, I. Tinhofer, B. Alinger, 2010, Oncogene.

Applicability of liquid biopsies to represent the mutational profile of tumor tissue from different cancer entities

M. Yaspo, F. Klauschen, I. Tinhofer, 2021, Oncogene.

Caffeine Confers Radiosensitization of PTEN-Deficient Malignant Glioma Cells by Enhancing Ionizing Radiation–Induced G1 Arrest and Negatively Regulating Akt Phosphorylation

V. Budach, I. Tinhofer, G. Tallen, 2010, Molecular Cancer Therapeutics.

Araxi O. Urrutia, I. Tinhofer, A. Ciarrocchi, 2023, PloS one.

Basal subtype is predictive for response to cetuximab treatment in patient‐derived xenografts of squamous cell head and neck cancer

U. Leser, I. Tinhofer, I. Fichtner, 2017, International journal of cancer.

Arsenic trioxide induces apoptosis preferentially in B-CLL cells of patients with unfavourable prognostic factors including del17p13

R. Greil, Z. Trajanoski, I. Tinhofer, 2008, Journal of Molecular Medicine.

Cancer stem cell characteristics of circulating tumor cells

V. Budach, I. Tinhofer, U. Keilholz, 2014, International journal of radiation biology.

Personalized biomarker-based treatment strategy for patients with squamous cell carcinoma of the head and neck: EORTC position and approach.

J. Machiels, J. Bogaerts, I. Tinhofer, 2018, Annals of oncology : official journal of the European Society for Medical Oncology.

Circulating tumor cells as biomarkers in head and neck cancer: recent advances and future outlook

I. Tinhofer, Stephanie Staudte, 2018, Expert review of molecular diagnostics.

Targeted next-generation sequencing identifies molecular subgroups in squamous cell carcinoma of the head and neck with distinct outcome after concurrent chemoradiation.

W. Weichert, A. Stenzinger, V. Budach, 2016, Annals of oncology : official journal of the European Society for Medical Oncology.

Activation of Ca2+ influx by transforming Ha-ras.

I. Tinhofer, H. Grunicke, K. Maly, 1995, Cell calcium.

patients with B-chronic lymphocytic leukemia Expression levels of CD38 in T-cells predict for course of disease in male

R. Greil, I. Tinhofer, M. Steurer, 2013 .

Expression levels of CD38 in T cells predict course of disease in male patients with B-chronic lymphocytic leukemia.

R. Greil, I. Tinhofer, M. Steurer, 2006, Blood.

Regulation of calcium signalling by the small GTP-binding proteins Ras and Rac1.

I. Tinhofer, H. Grunicke, I. Wede, 2007, Advances in enzyme regulation.

Prestaining of PCR products with SYBR Green for agarose gel electrophoresis: advantages and limitations

I. Tinhofer, R. Konschak, 2011, Clinical chemistry and laboratory medicine.

Regulation of the Receptor Tyrosine Kinase AXL in Response to Therapy and Its Role in Therapy Resistance in Glioblastoma

I. Tinhofer, P. Vajkoczy, I. Kremenetskaia, 2022, International journal of molecular sciences.

Targeted Next-Generation Sequencing in Head and Neck Cancer

I. Tinhofer, 2018 .

Development and validation of a 6-gene signature for the prognosis of loco-regional control in patients with HPV-negative locally advanced HNSCC treated by postoperative radio(chemo)therapy.

V. Budach, A. Abdollahi, I. Tinhofer, 2022, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Inhibition of histone deacetylase activity enhances Fas receptor-mediated apoptosis in leukemic lymphoblasts

R. Greil, D. Bernhard, I. Tinhofer, 2001, Cell Death and Differentiation.

Clinical outcome of pretreated B-cell chronic lymphocytic leukemia following alemtuzumab therapy: a retrospective study on various cytogenetic risk categories.

R. Greil, I. Tinhofer, M. Fiegl, 2010, Annals of oncology : official journal of the European Society for Medical Oncology.

Difference in the Relative Distribution of CD4+ T-cell Subsets in B-CLL With Mutated and Unmutated Immunoglobulin (Ig) VH Genes: Implication for the Course of Disease

R. Greil, I. Tinhofer, C. Holler, 2009, Journal of immunotherapy.

Enumeration and targeted analysis of KRAS, BRAF and PIK3CA mutations in CTCs captured by a label-free platform: Comparison to ctDNA and tissue in metastatic colorectal cancer

S. Jeffrey, J. Norton, I. Tinhofer, 2016, Oncotarget.

The PD‐1/PD‐L1 axis and human papilloma virus in patients with head and neck cancer after adjuvant chemoradiotherapy: A multicentre study of the German Cancer Consortium Radiation Oncology Group (DKTK‐ROG)

V. Budach, J. Debus, A. Abdollahi, 2017, International journal of cancer.

Characterization of the tumor immune micromilieu and its interference with outcome after concurrent chemoradiation in patients with oropharyngeal carcinomas

W. Weichert, V. Budach, I. Tinhofer, 2019, Oncoimmunology.

MiR-200b and miR-155 as predictive biomarkers for the efficacy of chemoradiation in locally advanced head and neck squamous cell carcinoma.

W. Weichert, A. Stenzinger, V. Budach, 2017, European journal of cancer.

Mutational load and mutational patterns in relation to age in head and neck cancer

Ulrich Keilholz, I. Tinhofer, U. Keilholz, 2016, Oncotarget.

Comparison of detection methods for HPV status as a prognostic marker for loco-regional control after radiochemotherapy in patients with HNSCC.

V. Budach, F. Buchholz, J. Debus, 2017, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

A systematic review of the HPV‐attributable fraction of oropharyngeal squamous cell carcinomas in Germany

I. Tinhofer, C. Wittekindt, J. Klussmann, 2019, Cancer medicine.

Negative enrichment by immunomagnetic nanobeads for unbiased characterization of circulating tumor cells from peripheral blood of cancer patients

Ulrich Keilholz, Zhian Liu, I. Tinhofer, 2010, Journal of Translational Medicine.

A comparative study of machine learning methods for time-to-event survival data for radiomics risk modelling

Steffen Löck, Mechthild Krause, Michael Baumann, 2017, Scientific Reports.

Eradication of EGFR-positive circulating tumor cells and objective tumor response with lapatinib and capecitabine

Ulrich Keilholz, Zhian Liu, Achim Schneider, 2010, Cancer biology & therapy.

Next-generation sequencing: hype and hope for development of personalized radiation therapy?

W. Weichert, A. Stenzinger, V. Budach, 2015, Radiation oncology.

Monitoring of circulating tumor cells and their expression of EGFR/phospho-EGFR during combined radiotherapy regimens in locally advanced squamous cell carcinoma of the head and neck.

V. Budach, I. Tinhofer, C. Stromberger, 2012, International journal of radiation oncology, biology, physics.

A simple multicolor flow cytometry protocol for detection and molecular characterization of circulating tumor cells in epithelial cancers

Volker Budach, V. Budach, I. Tinhofer, 2012, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Predictors for Adherence to Treatment Strategies in Elderly HNSCC Patients

I. Tinhofer, H. Olze, M. Beck, 2022, Cancers.

HPV status, cancer stem cell marker expression, hypoxia gene signatures and tumour volume identify good prognosis subgroups in patients with HNSCC after primary radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).

D. Aust, V. Budach, F. Buchholz, 2016, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Adjuvant simultaneous integrated boost IMRT for patients with intermediate- and high-risk head and neck cancer: outcome, toxicities and patterns of failure.

S. Marnitz, V. Budach, I. Tinhofer, 2014, Oral oncology.

Increased Growth-Inhibitory and Cytotoxic Activity of Arsenic Trioxide in Head and Neck Carcinoma Cells with Functional p53 Deficiency and Resistance to EGFR Blockade

V. Budach, I. Tinhofer, L. Distel, 2014, PloS one.

Transforming potentials of epidermal growth factor and nerve growth factor receptors inversely correlate with their phospholipase C gamma affinity and signal activation.

A. Ullrich, I. Tinhofer, H. Grunicke, 1996, The EMBO journal.

A comparative study of machine learning methods for time-to-event survival data for radiomics risk modelling

V. Budach, I. Tinhofer, S. Leger, 2017, Scientific Reports.

CCI-779 (Temsirolimus) exhibits increased anti-tumor activity in low EGFR expressing HNSCC cell lines and is effective in cells with acquired resistance to cisplatin or cetuximab

W. Weichert, A. Stenzinger, V. Budach, 2015, Journal of Translational Medicine.

Targeted next-generation sequencing of locally advanced squamous cell carcinomas of the head and neck reveals druggable targets for improving adjuvant chemoradiation.

W. Weichert, V. Budach, J. Debus, 2016, European journal of cancer.

Development and Validation of a Gene Signature for Patients with Head and Neck Carcinomas Treated by Postoperative Radio(chemo)therapy

V. Budach, F. Buchholz, J. Debus, 2018, Clinical Cancer Research.

The Role of Liquid Biopsies for Monitoring Disease Evolution

I. Tinhofer, 2021, Critical Issues in Head and Neck Oncology.

A multilayered epithelial mucosa model of head neck squamous cell carcinoma for analysis of tumor-microenvironment interactions and drug development.

I. Tinhofer, U. Keilholz, M. Schäfer-Korting, 2020, Biomaterials.

Mutational patterns of HPV+ and HPV- squamous cell carcinomas of the head and neck (SCCHN) and their interference with outcome after adjuvant chemoradiation: A multicenter biomarker study of the German Cancer Consortium Radiation Oncology Group.

J. Debus, V. Budach, A. Abdollahi, 2015 .

Systemic Application of Granulocyte-Colony Stimulating Factor and Stem Cell Factor Exacerbates Excitotoxic Brain Injury in Newborn Mice

P. Gressens, I. Tinhofer, G. Simbruner, 2006, Pediatric Research.

Definition and validation of a radiomics signature for loco-regional tumour control in patients with locally advanced head and neck squamous cell carcinoma

I. Tinhofer, S. Leger, S. Löck, 2021 .

Tuning the rheostat of the myelopoietic system via Fas and TRAIL.

R. Greil, I. Tinhofer, Gabriele Anether, 2003, Critical reviews in immunology.

Targeted next-generation sequencing of locally advanced squamous cell carcinomas of the head and neck reveals druggable targets for improving adjuvant chemoradiation Tinhofer

J. Debus, A. Abdollahi, I. Tinhofer, 2016 .

Regulation of apoptosis

L. Pleyer, R. Greil, I. Tinhofer, 2007 .

Patient and treatment-related risk factors for osteoradionecrosis of the jaw in patients with head and neck cancer.

V. Budach, I. Tinhofer, J. Raguse, 2016, Oral surgery, oral medicine, oral pathology and oral radiology.

Morphomolecular analysis of the immune tumor microenvironment in human head and neck cancer

W. Weichert, P. Schirmacher, A. Stenzinger, 2019, Cancer Immunology, Immunotherapy.

Gastric cancer cell lines lack Fas ligand (FasL) expression but kill T cells via a FasL independent pathway

R. Greil, I. Tinhofer, H. Wykypiel, 2000, Gut.

Minimal Residual Disease (MRD) and T/NK Cell Dynamics during Fludarabine, Cyclophosphamide Plus Rituximab (FCR) Followed by Fludarabine Plus Rituximab (FR) and Remission Maintenance Therapy with Rituximab in Previously Untreated B-Chronic Lymphocytic Leukemia (B-CLL): Riskfactor Stratification in th

L. Pleyer, R. Greil, I. Tinhofer, 2008 .

Liquid biopsy in head neck cancer: ready for clinical routine diagnostics?

I. Tinhofer, Stephanie Staudte, Stephen George, 2023, Current opinion in oncology.

Tumour mutational burden and survival with molecularly matched therapy.

S. Fröhling, F. Klauschen, I. Tinhofer, 2023, European journal of cancer.

Tetrocarcin-A--induced ER stress mediates apoptosis in B-CLL cells via a Bcl-2--independent pathway.

R. Greil, I. Tinhofer, Gabriele Anether, 2003, Blood.

Tetrocarcin-A--induced ER stress mediates apoptosis in B-CLL cells via a Bcl-2--independent pathway.

R. Greil, I. Tinhofer, Gabriele Anether, 2003, Blood.

V. Budach, J. Debus, A. Abdollahi, 2016, International journal of cancer.

MDM2 SNP309 is associated with poor outcome in B-cell chronic lymphocytic leukemia.

R. Greil, I. Tinhofer, M. Steurer, 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Personalized biomarker-based treatment strategy for patients with squamous cell carcinoma of the head and neck: EORTC position and approach.

J. Machiels, J. Bogaerts, I. Tinhofer, 2018, Annals of oncology : official journal of the European Society for Medical Oncology.

PET measured hypoxia and MRI parameters in re-irradiated head and neck squamous cell carcinomas: findings of a prospective pilot study [version 1; peer review: 1 approved, 1 approved with reservations]

H. Amthauer, F. Hofheinz, P. Wust, 2021 .

HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma: results from a multicentre explorative study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).

A. Abdollahi, I. Tinhofer, S. Pigorsch, 2014, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Analyses of molecular subtypes and their association to mechanisms ofradioresistance in patients with HPV-negative HNSCC treated bypostoperative radiochemotherapy.

V. Budach, A. Abdollahi, I. Tinhofer, 2022, Radiotherapy and Oncology.

The value of subcutaneous xenografts for individualised radiotherapy in HNSCC: robust gene signature correlates with radiotherapy outcome in patients and xenografts.

I. Tinhofer, S. Pigorsch, F. Lohaus, 2023, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Molecular subtyping of head and neck cancer - Clinical applicability and correlations with morphological characteristics.

I. Tinhofer, K. Klinghammer, M. Boxberg, 2024, Oral oncology.

Negative enrichment by immunomagnetic nanobeads for unbiased characterization of circulating tumor cells from peripheral blood of cancer patients

I. Tinhofer, E. Klopocki, U. Keilholz, 2011, Journal of Translational Medicine.

Caffeine Confers Radiosensitization of PTEN-Deficient Malignant Glioma Cells by Enhancing Ionizing Radiation–Induced G1 Arrest and Negatively Regulating Akt Phosphorylation

V. Budach, I. Tinhofer, G. Tallen, 2010, Molecular Cancer Therapeutics.

Multitask Learning with Convolutional Neural Networks and Vision Transformers Can Improve Outcome Prediction for Head and Neck Cancer Patients

I. Tinhofer, A. Zwanenburg, Karoline Leger, 2023, Cancers.

Retreatment with Alemtuzumab after a First, Successful Alemtuzumab Treatment in B-CLL.

R. Greil, I. Tinhofer, M. Fiegl, 2007 .

Planned First Safety and Efficacy Analysis of Oral Fludarabine Combined with Subcutaneous Alemtuzumab in 2 nd Line Therapy of B-Chronic Lymphocytic Leukaemia (B-CLL): The FLUSALEM Study.

R. Greil, I. Tinhofer, A. Egle, 2006 .