M. Hutton

J. Trojanowski, J. Hardy, D. Neary, 2004, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Differences in tau and apolipoprotein E polymorphism frequencies in sporadic frontotemporal lobar degeneration syndromes.

M. Hutton, N. Graff-Radford, M. Baker, 2002, Archives of neurology.

Saturday, March 17, 2007

R. Petersen, B. Boeve, D. Knopman, 2007, Neurodegenerative Diseases.

Presenilin mutations associated with fronto‐temporal dementia

M. Hutton, 2004, Annals of neurology.

Alzheimer’s Disease: A Matter of Dominance

J. Hardy, M. Hutton, J. Hardy, 1998 .

Identiﬁcation of a Novel Risk Locus for Progressive Supranuclear Palsy by a Pooled Genomewide Scan of 500,288 Single-Nucleotide Polymorphisms

Jason J. Corneveaux, D. Stephan, S. Melquist, 2007 .

Neurofibrillary tangle-related synaptic alterations of spinal motor neurons of P301L tau transgenic mice

D. Dickson, M. Hutton, Jada Lewis, 2006, Neuroscience Letters.

Tau Protein Is Cross-Linked by Transglutaminase in P301L Tau Transgenic Mice

M. Hutton, Jada Lewis, S. Frausto, 2005, The Journal of Neuroscience.

Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau

J. Hardy, M. Hutton, K. Duff, 1998, Nature Neuroscience.

Alzheimer disease PS-1 exon 9 deletion defined

A. Paetau, S. Lincoln, J. Hardy, 1999, Nature Medicine.

Clinical Features and Disease Haplotypes of Individuals With the N279K tau Gene Mutation

O. Rascol, B. Ghetti, R. Uitti, 2016 .

Molecular genetics of chromosome 17 tauopathies

M. Hutton, 2000, Neurobiology of Aging.

Altered conformation of recombinant frontotemporal dementia-17 mutant tau proteins

G. Jicha, P. Davies, M. Hutton, 1999, Neuroscience Letters.

Early Onset Alzheimer ’ s Disease with Spastic Paraparesis , Dysarthria and Seizures and N 135 S Mutation in PSEN 1

D. Dickson, M. Hutton, N. Graff-Radford, 2009 .

Progressive Supranuclear Palsy: Pathology and Genetics

Dennis W Dickson, D. Dickson, M. Hutton, 2007, Brain pathology.

Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms.

Richard J Caselli, John V Pearson, Irene Litvan, 2007, American journal of human genetics.

Voxel-based morphometry in frontotemporal lobar degeneration with ubiquitin-positive inclusions with and without progranulin mutations.

Clifford R Jack, Ronald C Petersen, David S Knopman, 2007, Archives of neurology.

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.

Cam Patterson, Michael Hutton, Leonard Petrucelli, 2007, The Journal of clinical investigation.

Anti-Aβ antibody target engagement: commentary regarding Watt et al. Acta Neuropathol 127:803–810 (2014)

K. Blennow, D. Holtzman, E. Siemers, 2014, Acta Neuropathologica.

Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets.

J. Trojanowski, V. Lee, M. Hutton, 2011, Cold Spring Harbor perspectives in medicine.

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

S. Melquist, D. Neary, B. Boeve, 2006, Nature.

Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study.

C. Jack, R. Petersen, B. Boeve, 2006, Brain : a journal of neurology.

Familial Frontotemporal Dementia Associated with a Novel Presenilin-1 Mutation

R. Petersen, R. Ivnik, J. Hardy, 2002, Dementia and Geriatric Cognitive Disorders.

Induction of Tau Pathology by Intracerebral Infusion of Amyloid-β-Containing Brain Extract and by Amyloid-β Deposition in APP × Tau Transgenic Mice

M. Staufenbiel, M. Hutton, M. Meyer-Luehmann, 2007 .

Heredofamilial brain calcinosis syndrome.

R. Uitti, M. Hutton, Z. Wszolek, 2005, Mayo Clinic proceedings.

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

Wen-Lang Lin, John Hardy, Peter Davies, 2000, Nature Genetics.

Alzheimer's Disease–Related Dementias Summit 2016: National research priorities

D. Holtzman, D. Bennett, C. Torborg, 2017, Neurology.

The presenilins and Alzheimer's disease.

J. Hardy, M. Hutton, J Hardy, 1997, Human molecular genetics.

Linkage disequilibrium and association of MAPT H1 in Parkinson disease.

M. Farrer, M. Hulihan, S. Lincoln, 2004, American journal of human genetics.

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

G. Schellenberg, J. Hardy, M. Viitanen, 1996, Nature Medicine.

5′ Splice Site Mutations in tau Associated with the Inherited Dementia FTDP-17 Affect a Stem-Loop Structure That Regulates Alternative Splicing of Exon 10*

A. Grover, M. Hutton, H. Houlden, 1999, The Journal of Biological Chemistry.

A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene

M. Adams, J. Hardy, M. Rossor, 1995, Neuroreport.

Journal of Neuroinflammation BioMed Central Review

D. Dickson, M. Hutton, I. Mackenzie, 2006 .

SLC20A2 and THAP1 deletion in familial basal ganglia calcification with dystonia

D. Dickson, J. Allanson, M. Hutton, 2014, neurogenetics.

SLC20A2 and THAP1 deletion in familial basal ganglia calcification with dystonia

Owen A. Ross, Dennis W. Dickson, A. Jon Stoessl, 2013, neurogenetics.

Genetic heterogeneity in familial idiopathic basal ganglia calcification (Fahr disease)

D H Geschwind, D B Calne, D. Geschwind, 2004, Neurology.

Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration.

D. Dickson, M. Hutton, Wen‐lang Lin, 2009, The American journal of pathology.

Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia

R. Petersen, S. Lincoln, B. Boeve, 2008, Human molecular genetics.

Novel Mutations in TARDBP (TDP-43) in Patients with Familial Amyotrophic Lateral Sclerosis

D. Geschwind, L. Petrucelli, R. Petersen, 2008, PLoS genetics.

P3-228 Chip and HSP70 regulate tau ubiquitination, degradation and aggregation

L. Petrucelli, M. Hutton, T. Dawson, 2004, Neurobiology of Aging.

Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.

S. Younkin, L. Younkin, M. de Andrade, 2003, Human molecular genetics.

Genetics of Alzheimer's disease.

J. Hardy, M. Hutton, J. Pérez-Tur, 1998, Essays in biochemistry.

Chromosome 14 familial Alzheimer’s disease: the clinical and neuropathological characteristics of a family with a leucine→serine (L250S) substitution at codon 250 of the presenilin 1 gene

Nick C Fox, J. Hardy, M. Rossor, 1998, Journal of neurology, neurosurgery, and psychiatry.

Early‐onset Alzheimer's disease with a presenilin‐1 mutation at the site corresponding to the volga German presenilin‐2 mutation

L. Thal, J. Hardy, Douglas Galasko, 1997, Annals of neurology.

Regional and Cellular Localization of Presenilin-2 RNA in Rat and Human Brain

N. Rothwell, M. Hutton, E. McGowan, 1997, Experimental Neurology.

Clinicopathological features of familial Alzheimer's disease associated with the M139V mutation in the presenilin 1 gene. Pedigree but not mutation specific age at onset provides evidence for a further genetic factor.

Nick C Fox, J. Hardy, P. Lantos, 1997, Brain : a journal of neurology.

Amyloid β protein (Aβ) deposition in chromosome 14–linked Alzheimer's disease: Predominance of Aβ42(43)

S. M. Sumi, P. Lantos, M. Rossor, 1996 .

Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease

A. Goate, M. Hutton, C. Talbot, 1996, The Lancet.

The Genes Involved in Alzheimer’s Disease

J. Hardy, M. Hutton, 1996 .

Progressive supranuclear palsy as a disease phenotype caused by the S305S tau gene mutation.

D W Dickson, D. Dickson, R. Uitti, 2001, Brain : a journal of neurology.

Recommendations of the Alzheimer's Disease–Related Dementias Conference

C. Torborg, T. Montine, C. Phelps, 2014, Neurology.

Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging.

L. Petrucelli, D. Dickson, M. Hutton, 2010, The American journal of pathology.

Progranulin expression correlates with dense‐core amyloid plaque burden in Alzheimer disease mouse models

S. Pereson, C. van Broeckhoven, M. Hutton, 2009, The Journal of pathology.

Review Article Tau: From research to clinical development

David S. Miller, M. Carrillo, D. Holtzman, 2016 .

Deletion of the Ubiquitin Ligase CHIP Leads to the Accumulation, But Not the Aggregation, of Both Endogenous Phospho- and Caspase-3-Cleaved Tau Species

Wen-Lang Lin, Guy A. Caldwell, Dennis W. Dickson, 2006, The Journal of Neuroscience.

A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17.

S. Melquist, H. Feldman, A. Sadovnick, 2006, Brain : a journal of neurology.

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.

J. Hardy, M. Viitanen, D. Selkoe, 1996, Nature medicine.

TDP‐43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease

D. Dickson, P. Davies, M. Hutton, 2007, Annals of neurology.

Conformation Determines the Seeding Potencies of Native and Recombinant Tau Aggregates

P. Szekeres, M. Hutton, M. Goedert, 2014, The Journal of Biological Chemistry.

A full genome scan for late onset Alzheimer's disease

M. Owen, P. Holmans, J. Hardy, 1999 .

Clinicopathologic correlation in PGRN mutations

M. Mesulam, E. Bigio, S. Weintraub, 2007, Neurology.

The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene.

H. Feldman, M. Hutton, G. Hsiung, 2006, Brain : a journal of neurology.

Characteristics of frontotemporal dementia patients with a Progranulin mutation

P. Pietrini, J. Grafman, J. Hardy, 2006, Annals of neurology.

Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau

P. Szekeres, M. Hutton, M. Goedert, 2016, The Journal of Neuroscience.

High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation

C. Beaudry, D. Stephan, E. Reiman, 2010, BMC Genomics.

Imbalance in the response of pre- and post-synaptic components to amyloidopathy

M. Hutton, AndrewD . Randall, M. O'Neill, 2019, Scientific Reports.

Specific Calpain Inhibition by Calpastatin Prevents Tauopathy and Neurodegeneration and Restores Normal Lifespan in Tau P301L Mice

M. Ohno, H. Sershen, A. Hashim, 2014, The Journal of Neuroscience.

Filling the Gaps in the Aβ Cascade Hypothesis of Alzheimers Disease

D. Dickson, M. Hutton, T. Golde, 2006 .

Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease.

D. Dickson, M. Hutton, T. Golde, 2006, Current Alzheimer research.

Research goals in progressive supranuclear palsy

M. Hallett, G. Schellenberg, B. Dubois, 2000, Movement disorders : official journal of the Movement Disorder Society.

Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation

S. Lovestone, R. Dayanandan, S. Lovestone, 1999, FEBS letters.

Increase in tau tyrosine phosphorylation correlates with the formation of tau aggregates.

Irving E. Vega, M. Hutton, S. Yen, 2005, Brain research. Molecular brain research.

Late-onset frontotemporal dementia associated with progressive supranuclear palsy/argyrophilic grain disease/Alzheimer’s disease pathology

R. Petersen, B. Boeve, D. Knopman, 2005, Neurocase.

Differential aberrant structural synaptic plasticity in axons and dendrites ahead of their degeneration in tauopathy

J. Isaac, M. Hutton, M. O'Neill, 2020, bioRxiv.

Altered Synapse Stability in the Early Stages of Tauopathy

J. Isaac, M. Hutton, AndrewD . Randall, 2017, Cell reports.

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

Zeshan Ahmed, Tracey K. Murray, Markus Tolnay, 2014, Acta Neuropathologica.

Beyond amyloid: the next generation of Alzheimer's disease therapeutics.

William J Ray, Michael Hutton, M. Hutton, 2007, Molecular interventions.

Two new genes for Alzheimer's disease

J. Hardy, M. Hutton, 1995, Trends in Neurosciences.

ApoE genotype is a risk factor in nonpresenilin early-onset Alzheimer's disease families.

J. Hardy, M. Rossor, C. van Broeckhoven, 1998, American journal of medical genetics.

Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS‐1 mutations that lead to exceptionally high amyloid‐β concentrations

A. Paetau, J. Hardy, M. Swash, 2000, Annals of neurology.

A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1

A. Paetau, M. Farrer, S. Lincoln, 1998, Nature Medicine.

Clinical-pathologic study of biomarkers in FTDP-17 (PPND family with N279K tau mutation).

B. Boeve, D. Dickson, J. Liss, 2007, Parkinsonism & related disorders.

Case‐control study of the extended tau gene haplotype in Parkinson's disease

D. Hernandez, M. Farrer, D. Maraganore, 2001, Annals of neurology.

An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice.

N. Plesnila, D. Dickson, M. Hutton, 2006, Proceedings of the National Academy of Sciences of the United States of America.

A Plaque-Specific Antibody Clears Existing β-amyloid Plaques in Alzheimer's Disease Mice

W. H. Jordan, M. Hutton, P. Mcdonnell, 2012, Neuron.

The genetics of frontotemporal dementia.

M. Hutton, Z. Wszolek, K. Haugarvoll, 2007, Neurologic clinics.

Clearing Tau Pathology with Aβ Immunotherapy—Reversible and Irreversible Stages Revealed

M. Hutton, E. McGowan, 2004, Neuron.

A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43).

J. Hardy, S. Younkin, M. Hutton, 1997, Human molecular genetics.

Plasma amyloid β protein is elevated in late-onset Alzheimer disease families

S. Younkin, L. Younkin, M. Hutton, 2008, Neurology.

Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene.

L. Feuk, R. Petersen, L. Hersh, 2005, Human molecular genetics.

Identification of a novel family of presenilin homologues.

C. Ponting, M. Hutton, T. Golde, 2002, Human molecular genetics.

Heritability of plasma amyloid β in typical late‐onset Alzheimer’s disease pedigrees

D. Schaid, S. Younkin, L. Younkin, 2001 .

Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.

J. Blangero, S. Younkin, L. Younkin, 2000, Science.

Prominent phenotypic variability associated with mutations in Progranulin

C. Jack, R. Petersen, R. Ivnik, 2009, Neurobiology of Aging.

Genetic studies on chromosome 12 in late-onset Alzheimer disease.

M. Owen, P. Holmans, J. Hardy, 1998, JAMA.

Suppression of MMP-9 by doxycycline in brain arteriovenous malformations

A. Singleton, D. Holtzman, J. Grafman, 2004, BMC neurology.

Astrocytes and neuroinflammation in Alzheimer's disease.

M. Hutton, W. Noble, D. Hanger, 2014, Biochemical Society transactions.

Alzheimer disease-like phenotype associated with the c.154delA mutation in progranulin.

R. Petersen, B. Boeve, Glenn E. Smith, 2010, Archives of neurology.

The microtubule associated protein Tau gene and Alzheimer's disease – an association study and meta-analysis

S. Lovestone, J. Powell, M. Cruts, 2001, Neuroscience Letters.

Risk‐reducing effect of education in Alzheimer's disease

S. Melquist, S. Lydersen, I. Saltvedt, 2008, International journal of geriatric psychiatry.

Accelerated filament formation from tau protein with specific FTDP‐17 missense mutations

M. Hutton, J. Hackett, Jada Lewis, 1999, FEBS letters.

Phosphorylated p38MAPK specific antibodies cross‐react with sarkosyl‐insoluble hyperphosphorylated tau proteins

Naruhiko Sahara, Irving E. Vega, Michael Hutton, 2004, Journal of neurochemistry.

Analysis of tauopathies with transgenic mice.

D. Dickson, M. Hutton, Jada Lewis, 2001, Trends in molecular medicine.

Apolipoprotein E alleles but neither apolipoprotein B nor apolipoprotein AI/CIII alleles are associated with late onset, familial Alzheimer's disease

J. Hardy, M. Rossor, J. Collinge, 1995, Neuroscience Letters.

Atypical Progressive Supranuclear Palsy With Corticospinal Tract Degeneration

Wen-Lang Lin, Keith A Josephs, Yasuhiro Fujino, 2006, Journal of neuropathology and experimental neurology.

Cortical Synapse Loss in Progressive Supranuclear Palsy

E. Bigio, M. Hutton, M. Baker, 2001, Journal of neuropathology and experimental neurology.

Frontal Lobe Dementia With Novel Tauopathy: Sporadic Multiple System Tauopathy With Dementia

D. Dickson, E. Bigio, P. Davies, 2001, Journal of neuropathology and experimental neurology.

Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression

L. Petrucelli, M. Hutton, C. Eckman, 2006, Molecular Neurodegeneration.

Filamentous tau in oligodendrocytes and astrocytes of transgenic mice expressing the human tau isoform with the P301L mutation.

D. Dickson, M. Hutton, Jada Lewis, 2003, The American journal of pathology.

The L266V tau mutation is associated with frontotemporal dementia and Pick-like 3R and 4R tauopathy

M. Mesulam, D. Dickson, E. Bigio, 2003, Acta Neuropathologica.

Hippocampal Sclerosis Dementia with Tauopathy

Douglas Walker, Michael Hutton, Thomas G Beach, 2003, Brain pathology.

Missense and splice site mutations in tau associated with FTDP-17: Multiple pathogenic mechanisms

M. Hutton, 2001, Neurology.

Frequency of tau mutations in three series of non‐Alzheimer's degenerative dementia

R. Petersen, D. Neary, B. Boeve, 1999, Annals of neurology.

Inherited frontotemporal dementia in nine British families associated with intronic mutations in the tau gene.

J. Hardy, D. Neary, D. Mann, 2002, Brain : a journal of neurology.

Autosomal dominant dystonia-plus with cerebral calcifications

S. Melquist, R. Uitti, J. Allanson, 2006, Neurology.

An Unbiased Approach to Identifying Tau Kinases That Phosphorylate Tau at Sites Associated with Alzheimer Disease

S. Brewerton, P. Davies, P. Szekeres, 2013, The Journal of Biological Chemistry.

Parkinson's disease, but not Alzheimer's disease, Lewy body variant associated with mutant alleles at cytochrome P450 gene

J. Hardy, M. Hutton, H. Houlden, 1994, The Lancet.

A family with a tau P301L mutation presenting with parkinsonism.

M. Farrer, J. Hardy, K. Gwinn‐Hardy, 2002, Parkinsonism & related disorders.

Development of a high throughput drug screening assay for the detection of changes in tau levels -- proof of concept with HSP90 inhibitors.

L. Petrucelli, S. Kasibhatla, M. Hutton, 2005, Current Alzheimer research.

Progranulin mutations in primary progressive aphasia: the PPA1 and PPA3 families.

Nancy Johnson, Sandra Weintraub, Marsel Mesulam, 2007, Archives of neurology.

Gene expression study on peripheral blood identifies progranulin mutations

D. Geschwind, G. Coppola, A. Karydas, 2008, Annals of neurology.

Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures

Michele Zagnoni, Antigoni Katsikoudi, Gary Sharman, 2020, The Journal of Biological Chemistry.

Mutant torsinA interacts with tyrosine hydroxylase in cultured cells

P. Lockhart, M. Cookson, M. Hutton, 2009, Neuroscience.

A novel calcium‐binding protein is associated with tau proteins in tauopathy

Irving E. Vega, D. Dickson, M. Hutton, 2008, Journal of neurochemistry.

Mutations in progranulin explain atypical phenotypes with variants in MAPT.

B. Boeve, R. Martins, P. Schofield, 2006, Brain : a journal of neurology.

Neurodegenerative diseases of Guam: Analysis of TAU

J. Hardy, A. Delacourte, L. Buée, 1999, Neurology.

Epidemiology and genetics of frontotemporal dementia/Pick's disease

D. Geschwind, D. Knopman, H. Feldman, 2003, Annals of neurology.

Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau

D. Dickson, M. Hutton, Jada Lewis, 2003, Journal of neurocytology.

Corticobasal Degeneration and Frontotemporal Dementia Presentations in a Kindred with Nonspecific Histopathology

R. Petersen, R. Ivnik, D. Maraganore, 2002, Dementia and Geriatric Cognitive Disorders.

HSP induction mediates selective clearance of tau phosphorylated at proline‐directed Ser/Thr sites but not KXGS (MARK) sites

L. Petrucelli, M. Hutton, C. Eckman, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The genetics of frontotemporal dementia.

M. Hutton, S. Pickering-Brown, 2008, Handbook of clinical neurology.

Tau proteins with frontotemporal dementia-17 mutations have both altered expression levels and phosphorylation profiles in differentiated neuroblastoma cells

S. Lovestone, M. Hutton, A. Whone, 2001, Neuroscience.

Apoptosis in oligodendrocytes is associated with axonal degeneration in P301L tau mice

D. Dickson, M. Hutton, Jada Lewis, 2004, Neurobiology of Disease.

The genetics of disorders with synuclein pathology and parkinsonism.

M. Farrer, J. Hardy, K. Gwinn‐Hardy, 1999, Human molecular genetics.

APOE is a potential modifier gene in an autosomal dominant form of frontotemporal dementia (IBMPFD)

Charles D. Smith, S. Mehta, M. Hutton, 2007, Genetics in Medicine.

H1/H1 genotype influences symptom severity in corticobasal syndrome

I. Litvan, M. Hutton, A. Cambon, 2010, Movement disorders : official journal of the Movement Disorder Society.

No association between TAU haplotype and Alzheimer's disease in population or clinic based series or in familial disease

R. Petersen, J. Hardy, B. Boeve, 2000, Neuroscience Letters.

Clinical features of pathologic subtypes of behavioral--variant frontotemporal dementia.

William T. Hu, R. Petersen, B. Boeve, 2007, Archives of neurology.

APOE ε4 lowers age at onset and is a high risk factor for Alzheimer's disease; A case control study from central Norway

Stian Lydersen, Ingvild Saltvedt, Olav Sletvold, 2008, BMC neurology.

Clinical and Genetic Aspects of Progressive Supranuclear Palsy

I. Litvan, M. Hutton, Irene Litvan, 1998, Journal of geriatric psychiatry and neurology.

Presenilin-1 is processed into two major cleavage products in neuronal cell lines.

J. Hardy, M. Hutton, M. Caivano, 1996, Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration.

Determination of the gene structure of human GFAP and absence of coding region mutations associated with frontotemporal dementia with parkinsonism linked to chromosome 17.

M. Hutton, F. Wavrant‐De Vrièze, M. Baker, 1998, Genomics.

Oral Treatment with a γ-Secretase Inhibitor Improves Long-Term Potentiation in a Mouse Model of Alzheimer's Disease

M. Hutton, Zhenhua Wu, A. Gray, 2010, Journal of Pharmacology and Experimental Therapeutics.

CHMP2B mutations are not a common cause of frontotemporal lobar degeneration

D. Neary, B. Boeve, D. Knopman, 2006, Neuroscience Letters.

Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations

J. Morris, J. Hardy, C. Duijn, 1999, Neuroscience Letters.

Apolipoprotein epsilon4 allele frequency in young Africans of Ugandan descent versus African Americans.

M. Hutton, N. Graff-Radford, J. Adamson, 2003, Journal of the National Medical Association.

Apolipoprotein ∈4 allele frequency in young Africans of Ugandan descent versus African Americans

M. Hutton, N. Graff-Radford, J. Adamson, 2003 .

[Genetics of Parkinson's disease].

M. Farrer, J. Hardy, M. Hutton, 2001 .

Evidence for independent mechanisms and a multiple-hit model of tau assembly.

A. Grover, M. Hutton, S. Yen, 2006, Biochemical and biophysical research communications.

A novel candidate presenilin-1 interacting protein containing tetratricopeptide repeats.

J. Hardy, M. Hutton, M. Baker, 1999, NeuroReport.

Progranulin in frontotemporal lobar degeneration and neuroinflammation

D. Dickson, M. Hutton, I. Mackenzie, 2007, Journal of Neuroinflammation.

Genetics of Alzheimer's disease.

J. Hardy, R. Guerreiro, M. Hutton, 1998, Essays in biochemistry.

Analysis of IFT 74 as a candidate gene for chromosome 9 p-linked ALS-FTD

D. Holtzman, J. Grafman, N. Cairns, 2015 .

Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau

John Hardy, M. Hutton, K. Duff, 1998, Nature Neuroscience.

Recommendations of the Alzheimer's disease-related dementias conference.

C. Torborg, T. Montine, C. Phelps, 2014, Neurology.

Progressive white matter pathology in the spinal cord of transgenic mice expressing mutant (P301L) human tau

D. Dickson, M. Hutton, Jada Lewis, 2005, Journal of neurocytology.

The role of presenilin 1 in the genetics of Alzheimer's disease.

M. Adams, J. Hardy, A. Goate, 1996, Cold Spring Harbor symposia on quantitative biology.

Construction of a detailed physical and transcript map of the FTDP-17 candidate region on chromosome 17q21.

M. V. van Baren, J. Hardy, P. Nowotny, 1999, Genomics.

Tackling gaps in developing life-changing treatments for dementia

S. Lovestone, J. Rohrer, L. Jones, 2019 .

Tackling gaps in developing life-changing treatments for dementia

S. Lovestone, J. Rohrer, L. Jones, 2019 .

Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau

Scott T. Grafton, G. E. Alexander, D. Pélisson, 1998, Nature Neuroscience.

Molecular Genetics and Transgenic Modeling of the Tauopathies

M. Hutton, M. Baker, Jada Lewis, 2002 .

Evidence for an association between KIBRA and late-onset Alzheimer's disease

Jason J. Corneveaux, Winnie S. Liang, G. Alexander, 2010, Neurobiology of Aging.

Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP

D. Dickson, M. Hutton, C. Eckman, 2001, Science.

Closing the tau loop: the missing tau mutation.

S. Fahn, E. Huey, M. Hutton, 2015, Brain : a journal of neurology.

Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau

P. Szekeres, M. Hutton, M. Goedert, 2016, The Journal of Neuroscience.

Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging.

L. Petrucelli, D. Dickson, M. Hutton, 2010, The American journal of pathology.