S. Edelstein

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The Sickled Cell: From Myths to Molecules

S. Edelstein, 1986 .

An allosteric model of calmodulin explains differential activation of PP2B and CaMKII

Melanie I. Stefan, N. L. Le Novère, S. Edelstein, 2008, Proceedings of the National Academy of Sciences.

Biophysical Perspective Biased Allostery

J. Changeux, S. Edelstein, 2016 .

Biased Allostery.

J. Changeux, S. Edelstein, 2016, Biophysical journal.

Conformational selection or induced fit? 50 years of debate resolved

J. Changeux, S. Edelstein, 2011, F1000 biology reports.

Allosteric Mechanisms of Signal Transduction

J. Changeux, S. Edelstein, 2005, Science.

Paradoxical allosteric effects of competitive inhibitors on neuronal α7 nicotinic receptor mutants

J. Changeux, D. Bertrand, S. Edelstein, 1997, Neuroreport.

Pairings and polarities of the 14 strands in sickle cell hemoglobin fibers.

S. Edelstein, D. Rodgers, R. H. Crepeau, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Brain nicotinic receptors: structure and regulation, role in learning and reinforcement 1 Published on the World Wide Web on 24 October 1997. 1

J. Changeux, S. Dehaene, N. Novère, 1998, Brain Research Reviews.

Functional aspects of the subunit association-dissociation equilibria of hemoglobin.

S. Edelstein, Q. Gibson, J. Olson, 1970, The Journal of biological chemistry.

Identification of a pre-active conformation of a pentameric channel receptor

Marc Delarue, Pierre-Jean Corringer, M. Delarue, 2017, eLife.

Ligand Depletion in vivo Modulates the Dynamic Range and Cooperativity of Signal Transduction

Melanie I. Stefan, Nicolas Le Novère, Stuart J. Edelstein, 2010, PloS one.

Allosteric receptors after 30 years

J. Changeux, S. Edelstein, 2006 .

Extensions of the Allosteric Model for Haemoglobin

S. Edelstein, 1971, Nature.

Allosteric receptors after 30 years

J. Changeux, S. Edelstein, Jean-Pierre Changeux, 1998, Neuron.

Cooperativity of allosteric receptors.

N. L. Le Novère, S. Edelstein, 2013, Journal of molecular biology.

Allosteric proteins after thirty years: The binding and state functions of the neuronalα7 nicotinic acetylcholine receptors

J. Changeux, S. Edelstein, Stuart J. Edelstein, 1996, Experientia.

Steric and hydrophobic determinants of the solubilities of recombinant sickle cell hemoglobins

M. Bihoreau, S. Edelstein, O. Schaad, 1992, Protein science : a publication of the Protein Society.

Breeding novel solutions in the brain: a model of Darwinian neurodynamics

Eörs Szathmáry, Karl J. Friston, Karl Friston, 2016, F1000Research.

Microtubules, sickle cell hemoglobin fibers, and various crystal structures

T. Ceska, S. Edelstein, C. Akey, 1983 .

Allosteric transitions of the acetylcholine receptor.

J. Changeux, S. Edelstein, Jean-Pierre Changeux, 1998, Advances in protein chemistry.

Enhanced quaternary stability of beta hemoglobin in 2 M-sodium chloride.

S. Edelstein, M. Tainsky, 1973, Journal of molecular biology.

Sedimentation equilibrium of paucidisperse systems. Subunit structure of complemented beta-galactosidase.

S. Edelstein, M. Goldberg, 1969, Journal of molecular biology.

The simultaneous determination of partial specific volumes and molecular weights with microgram quantities.

S. Edelstein, H. K. Schachman, Stuart J. Edelstein, 1967, The Journal of biological chemistry.

Three-dimensional reconstruction of tubulin in zinc-induced sheets. II. Consequences of removal of microtubule associated proteins.

T. Ceska, S. Edelstein, 1984, Journal of molecular biology.

Using Chemical Kinetics to Model Neuronal Signalling Pathways

Melanie I. Stefan, N. Novère, L. Endler, 2012 .

The multiple phenotypes of allosteric receptor mutants.

J. Changeux, S. Edelstein, J. Galzi, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Neurogranin Stimulates Ca2+/calmodulin-dependent Kinase II by Inhibiting Calcineurin at Specific Calcium Spike Frequencies

Lu Li, N. L. Le Novère, S. Edelstein, 2019, bioRxiv.

to the activation mechanism

J. Changeux, S. Edelstein, P. Corringer, 2022 .

Conformation and spin state in methemoglobin.

S. Edelstein, P. Hensley, D. Wharton, 1975, The Journal of biological chemistry.

Oxygen binding and subunit interaction of hemoglobin in relation to the two-state model.

S. Edelstein, Q. Gibson, 1987, The Journal of biological chemistry.

Functional consequences of mutations at the allosteric interface in hetero‐ and homo‐hemoglobin tetramers

M. Bihoreau, S. Edelstein, O. Schaad, 1993, Protein science : a publication of the Protein Society.

Overexpression of tubulin in yeast: differences in subunit association.

S. Edelstein, D. Bollag, R. Stalder, 1990, European journal of cell biology.

An expanded two-state allosteric model for interactions of human hemoglobin A with nonsaturating concentrations of 2,3-diphosphoglycerate.

S. Edelstein, J. Kister, C. Poyart, 1987, The Journal of biological chemistry.

Functional Properties of β-Tubulin In Vivo

S. Edelstein, D. Bollag, M. Rozycki, 1989 .

Diameter of haemoglobin S fibres in sickled cells

S. Edelstein, R. Garrell, R. H. Crepeau, 1978, Nature.

Differences in α and β polypeptide chains of tubulin resolved by electron microscopy with image reconstruction

B. McEwen, S. Edelstein, R. H. Crepeau, 1978 .

Oblique alignment of hemoglobin S fibers in sickled cells.

S. Edelstein, R. H. Crepeau, 1979, Journal of molecular biology.

The innermost chorionic layer of Drosophila. I. The role of chorin octamers in the formation of a family of interdigitating crystalline plates.

S. Edelstein, C. Akey, 1987, Journal of molecular biology.

The innermost chorionic layer of Drosophila. II. Three-dimensional structure determination of the 90 degrees crystal form by electron microscopy.

S. Edelstein, C. Akey, R. H. Crepeau, 1987, Journal of molecular biology.

On the subunit structure of the cold labile adenosine triphosphatase of mitochondria.

S. Edelstein, G. Forrest, 1970, The Journal of biological chemistry.

Ultracentrifuge studies with absorption optics. IV. Molecular weight determinations at the microgram level.

S. Edelstein, H. K. Schachman, 1966, Biochemistry.

The effect of functional differences in the alpha and beta chains on the cooperativity of the osidation reduction reaction of hemoglobin.

S. Edelstein, W. H. Gibson, 1975, Journal of Biological Chemistry.

Acetylcholine receptor oligomers from electroplax of Torpedo species.

S. Edelstein, R. O'brien, R. Gibson, 1976, Biochemistry.

Conservation of tubulin α-β differences in zinc-induced sheets with variations in pH and microtubule-associated protein content

S. Edelstein, F. Stetzkowski-Marden, M. Rozycki, 1988 .

Double strand packing in hemoglobin S fibers.

S. Edelstein, I. Cretegny, Isabelle Cretegny, 1993, Journal of molecular biology.

Identifying the conformational state of bi-liganded haemoglobin

S. Edelstein, L. Kiger, M. Marden, 1998, Cellular and Molecular Life Sciences CMLS.

Observation of the dissociation of unliganded hemoglobin.

S. Edelstein, J. O. Thomas, 1972, The Journal of biological chemistry.

Cat Hemoglobin: pH-Dependent Cooperativity of Oxygen Binding

S. Edelstein, M. N. Hamilton, M. N. Hamilton, 1972, Science.

A kinetic mechanism for nicotinic acetylcholine receptors based on multiple allosteric transitions

Stuart J. Edelstein, Olivier Schaad, Eric Henry, 1996, Biological Cybernetics.

Cooperative interactions of hemoglobin.

S. Edelstein, S J Edelstein, 1975, Annual review of biochemistry.

Human ribosomal RNA gene arrays display a broad range of palindromic structures.

S. Edelstein, R. Lebofsky, S. Caburet, 2005, Genome research.

Oxygen-organophosphate linkage in hemoglobin A. The double hump effect.

S. Edelstein, J. Kister, C. Poyart, 1987, Biophysical journal.

Self-association of haemoglobin Olympia (alpha 2 beta 2 20 (B2) Val----Met). A human haemoglobin bearing a substitution at the surface of the molecule.

S. Edelstein, J. Kister, Y. Blouquit, 1986, Journal of molecular biology.

MANGANESE‐SUBSTITUTED HEMOGLOBIN AND MYOGLOBIN *

S. Edelstein, Q. Gibson, B. Hoffman, 1975, Annals of the New York Academy of Sciences.

Manganese hemoglobin: allosteric effects in stopped flow flash photolysis and sedimentation measurements.

S. Edelstein, Q. Gibson, B. Hoffman, 1974, Biochemical and biophysical research communications.

Analysis of hemoglobin oxygen equilibrium curves. Are unique solutions possible?

S. Edelstein, M. Marden, J. Kister, 1989, Journal of molecular biology.

Subunit dissociation in fish hemoglobins.

S. Edelstein, Q. Gibson, B. McEwen, 1976, The Journal of biological chemistry.

Linkage between ligand binding and the dimer-tetramer equilibrium in the Monod-Wyman-Changeux model of hemoglobin.

S. Edelstein, J. Edsall, 1986, Proceedings of the National Academy of Sciences of the United States of America.

A Novel Equation for Cooperativity of the Allosteric State Function

S. Edelstein, 2014, Journal of molecular biology.

Derivation of the Crick-Wyman equation for allosteric proteins defining the difference between the number of binding sites and the Hill coefficient.

S. Edelstein, F. Poitevin, 2013, Journal of molecular biology.

[4] Measurement of partial specific volume by sedimentation equilibrium in H2OD2O solutions

S. Edelstein, H. K. Schachman, 1973 .

Chapter 25. Sickle Cell Anemia

S. Edelstein, 1985 .

Electron microscopic studies of the intracellular polymerization of sickle hemoglobin.

A. Schechter, S. Edelstein, C. Reindorf, 1988, Blood cells.

Three-dimensional reconstruction of the fibres of sickle cell haemoglobin

S. Edelstein, R. H. Crepeau, G. Dykes, 1978, Nature.

SICKLE CELL ANAEMIA AND REINCARNATION BELIEFS IN NIGERIA

S. Edelstein, I. Stevenson, 1983, The Lancet.

Structure of fibers of sickle cell hemoglobin.

S. Edelstein, R. H. Crepeau, J. Telford, 1973, Proceedings of the National Academy of Sciences of the United States of America.

Molecular topology in crystals and fibers of hemoglobin S.

S. Edelstein, 1981, Journal of molecular biology.

Three-dimensional reconstruction of the 14-filament fibers of hemoglobin S.

S. Edelstein, R. H. Crepeau, G. Dykes, 1979, Journal of molecular biology.

Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors

J. Changeux, S. Edelstein, 2001, Current Opinion in Neurobiology.

Ultracentrifugal studies with absorption optics and a split-beam photoelectric scanner.

S. Edelstein, H. K. Schachman, 1973, Methods in enzymology.

An allosteric mechanism for the acetylcholine receptor.

S. Edelstein, S J Edelstein, 1972, Biochemical and biophysical research communications.

Polarity of the 14-strand fibers of sickle cell hemoglobin determined by cross-correlation methods.

S. Edelstein, R. H. Crepeau, 1984, Ultramicroscopy.

Allosteric Receptors after 30 Years Review the presence of several identical subunits assembled

J. Changeux, S. Edelstein, 1998 .

Cat hemoglobin. pH dependence of cooperativity and ligand binding.

S. Edelstein, M. N. Hamilton, 1974, The Journal of biological chemistry.

Characterization of crystals of a cytochrome oxidase (nitrite reductase) from Pseudomonas aeruginosa by x-ray diffraction and electron microscopy.

S. Edelstein, C. Akey, D. Wharton, 1980, Journal of molecular biology.

Sickle cell hemoglobin fiber formation strongly inhibited by the stanleyville II mutation (α78 Asn → Lys)

S. Edelstein, Y. Blouquit, J. Rosa, 1983 .

Sickle cell hemoglobin fiber formation strongly inhibited by the Stanleyville II mutation (alpha 78 Asn leads to Lys).

S. Edelstein, Y. Blouquit, J. Rosa, 1983, Biochemical and biophysical research communications.

Hemoglobin Saint Mandé [β102 (G4) Asn→Tyr]

S. Edelstein, O. Schaad, J. Kister, 1990 .

Hemoglobin Saint Mandé [beta 102 (G4) Asn----Tyr]. Functional studies and structural modeling reveal an altered T state.

S. Edelstein, O. Schaad, J. Kister, 1990, European journal of biochemistry.

Molecular weight of the acetylcholine receptors of electric organs and the effect of Triton X-100.

S. Edelstein, M. E. Elderfrawi, W. B. Beyer, 1975, The Journal of biological chemistry.

Trigonal catalase crystals: a new molecular packing assignment obtained from sections preserved with tannic acid.

S. Edelstein, C. Akey, M. Szalay, 1984, Ultramicroscopy.

Structural preservation and absolute contrast of catalase crystal sections prepared with tannic acid

S. Edelstein, C. Akey, M. Szalay, 1983 .

Equivalence of the projected structure of thin catalase crystals preserved for electron microscopy by negative stain, glucose or embedding in the presence of tannic acid.

S. Edelstein, C. Akey, 1983, Journal of molecular biology.

Ligand-Dependent Opening of the Multiple AMPA Receptor Conductance States: A Concerted Model

Christian Rosenmund, N. L. Le Novère, S. Edelstein, 2014, PloS one.

Modulation of Calmodulin Lobes by Different Targets: An Allosteric Model with Hemiconcerted Conformational Transitions

Nicolas Le Novère, Stuart J. Edelstein, Massimo Lai, 2014, PLoS Comput. Biol..

Computing phenomenologic Adair-Klotz constants from microscopic MWC parameters

Melanie I. Stefan, Nicolas Le Novère, Stuart J. Edelstein, 2009, BMC Systems Biology.

Allosteric Receptors after 30 Years Review

J. Changeux, S. Edelstein, 1998 .

Structural differences in the two agonist binding sites of the Torpedo nicotinic acetylcholine receptor revealed by time-resolved fluorescence spectroscopy.

J P Changeux, J. Changeux, S. Edelstein, 2000, Biochemistry.

Desensitization of neuronal nicotinic acetylcholine receptors conferred by N-terminal segments of the beta 2 subunit.

J. Changeux, D. Bertrand, S. Edelstein, 2001, Biochemistry.

Three-dimensional Reconstruction of the 14-Filament Fibers of Hemoglobin

S. Edelstein, S. Gem, 2003 .

Structural studies on porcine brain tubulin in extended sheets.

S. Edelstein, B. McEwen, R. H. Crepeau, 1977, Journal of molecular biology.

Evidence for a mixed lattice in microtubules reassembled in vitro.

S. Edelstein, B. McEwen, 1980, Journal of molecular biology.

Differences in alpha and beta polypeptide chains of tubulin resolved by electron microscopy with image reconstruction.

S. Edelstein, B. McEwen, R. H. Crepeau, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Three-dimensional reconstruction of tubulin in zinc-induced sheets.

S. Edelstein, L. Tamm, R. H. Crepeau, 1984, Journal of molecular biology.

Structural changes in tubulin sheets upon removal of microtubule-associated proteins.

T. Ceska, S. Edelstein, B. McEwen, 1983, Journal of molecular biology.

Patterns in the quinary structures of proteins. Plasticity and inequivalence of individual molecules in helical arrays of sickle cell hemoglobin and tubulin.

S. Edelstein, S J Edelstein, 1980, Biophysical journal.

Electron microscopy and single molecule averaging of subunit‐deficient F1‐ATPases from Escherichia coli and spinach chloroplasts.

S. Dunn, S. Edelstein, C. Akey, 1983, The EMBO journal.

Electron microscopy andsingle molecule averaging ofsubunit- deficient F1-ATPases fromEscherichia coli andspinach chloroplasts

S. Dunn, S. Edelstein, C. Akey, 1983 .

An H‐bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors

J. Changeux, N. L. Le Novère, S. Edelstein, 2003, The EMBO journal.

The Neurokinin A Receptor Activates Calcium and cAMP Responses through Distinct Conformational States*

S. Edelstein, J. Galzi, B. Bucher, 2001, The Journal of Biological Chemistry.

Studies on the structure of the acetylcholine receptor from Torpedo marmorata.

S. Edelstein, M. Eldefrawi, R. C. Carroll, 1973, Biochemical and biophysical research communications.

Molecular tuning of fast gating in pentameric ligand-gated ion channels.

J. Changeux, S. Edelstein, A. Taly, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Relationships between Structural Dynamics and Functional Kinetics in Oligomeric Membrane Receptors

J. Changeux, S. Edelstein, 2010, Biophysical journal.

Neurogranin stimulates Ca2+/calmodulin-dependent kinase II by suppressing calcineurin activity at specific calcium spike frequencies

Nicolas Le Novère, Stuart J. Edelstein, Massimo Lai, 2020, PLoS Comput. Biol..

Critical Elements Determining Diversity in Agonist Binding and Desensitization of Neuronal Nicotinic Acetylcholine Receptors

J. Changeux, D. Bertrand, S. Edelstein, 1998, The Journal of Neuroscience.

Polymorphism of sickle cell hemoglobin fibers.

R. Josephs, S. Edelstein, H. Jarosch, 1976, Journal of molecular biology.

Enhanced polymerization of recombinant human deoxyhemoglobin beta 6 Glu----Ile.

S. Edelstein, O. Schaad, M. Marden, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Intermediate closed state for glycine receptor function revealed by cysteine cross-linking

J. Changeux, S. Edelstein, P. Corringer, 2013, Proceedings of the National Academy of Sciences.

Single binding versus single channel recordings: a new approach to study ionotropic receptors.

J. Changeux, S. Edelstein, O. Schaad, 1997, Biochemistry.

Myasthenic nicotinic receptor mutant interpreted in terms of the allosteric model.

J. Changeux, S. Edelstein, O. Schaad, 1997, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie.

Electron microscopy of single molecules and crystals of F1-ATPases.

S. Dunn, S. Edelstein, C. Akey, 1986, Methods in enzymology.

Influence of inositol hexaphosphate binding on subunit dissociation in methemoglobin.

S. Edelstein, P. Hensley, K. Moffat, 1975, The Journal of biological chemistry.

The polymerization of nickel (II) hemoglobin S under aerobic conditions.

S. Edelstein, D. Rodgers, R. Nagel, 1984, Blood.

A Plausible Molecular Model for the 14-Filament Fibers of Sickle Cell Hemoglobin

S. Edelstein, 1981 .

Contributions of individual molecular species to the Hill coefficient for ligand binding by an oligomeric protein.

S. Edelstein, W. Bardsley, 1997, Journal of molecular biology.

Allosteric interactions after 50 years.

S. Edelstein, 2013, Journal of molecular biology.

Sickle cell hemoglobin fiber structure altered by alpha-chain mutation.

S. Edelstein, R. H. Crepeau, R. Edalji, 1981, Proceedings of the National Academy of Sciences of the United States of America.

An allosteric theory for hemoglobin incorporating asymmetric states to test the putative molecular code for cooperativity.

S. Edelstein, 1996, Journal of molecular biology.

Cooperative interactions of hemoglobin.

S. Edelstein, 1975, Annual review of biochemistry.

Observation of the dissociation of unliganded hemoglobin. II. Effect of pH, salt, and dioxane.

S. Edelstein, J. O. Thomas, 1973, The Journal of biological chemistry.

Molecular weights and volumes from density perturbation ultracentrifugation. Application to aldolase and deoxyribonucleic acid polymerase in solutions of guanidine hydrochloride.

S. Edelstein, J. O. Thomas, 1971, Biochemistry.

A modified purification method and properties of pure porcine d-amino acid oxidase

S. Edelstein, S. Tu, D. B. Mccormick, 1973 .

On allosteric mechanisms and acetylcholine receptors.

J P Changeux, J. Changeux, S. Edelstein, 1994, Trends in biochemical sciences.

Analytical ultracentrifugation with absorption optics and a scanner-computer system. Applications to molecular weight measurements on interacting systems.

S. Edelstein, R. H. Crepeau, C. Hensley, 1974, Biochemistry.

Extensions of the allosteric model for hemoglobin. II. Consequences of functional nonequivalence of the alpha and beta chains.

S. Edelstein, S J Edelstein, 1974, Biochemistry.

An alternative paradigm for hominoid evolution

S. Edelstein, 1987 .

Chemistry, an introduction to general, organic and biological chemistry

Stuart J. Edelstein, J. Widom, S. Edelstein, 1981 .