S. Sieburth

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Distributed Heuristic Synthesis Search

Herbert L. Gelernter, Daren Krebsbach, Scott McN. Sieburth, 1998, J. Chem. Inf. Comput. Sci..

3-4'-Bipiperidines via sequential [4 + 4]-[3,3]-retro-Mannich reactions.

S. Sieburth, P. Carroll, Peiling Chen, 2009, Organic letters.

Photochemical Reactivity of Pyridones

S. Sieburth, 2004 .

Silanol reactivity : evaluation of silanolate as a metalation-directing group

S. Sieburth, L. Fensterbank, 1993 .

Stereoselective Late-Stage Transformations of Indolo[2,3-a]quinolizines Skeleta to Nature-Inspired Scaffolds.

S. Sieburth, T. Al‐Tel, V. Srinivasulu, 2021, The Journal of organic chemistry.

Efficient asymmetric synthesis of silanediol precursors from 1,5-dihydrosiloles.

S. Sieburth, Yingmei Qi, Sushmita Sen, 2007, Organic letters.

β-Peptide coatings by surface-initiated polymerization.

S. Sieburth, G. Baran, Yong Lei, 2012, Chemical communications.

Carbocyclic Amino Ketones by Bredt's Rule-Arrested Kulinkovich-de Meijere Reaction.

S. Sieburth, Paul B. Finn, Brenden P. Derstine, 2016, Angewandte Chemie.

Intramolecular Reactions of Temporarily Silicon-Tethered Molecules

S. Sieburth, L. Fensterbank, M. Malacria, 1997 .

Diastereoselectivity during 2-pyridone photo-[4+4] cycloaddition. The tribenzylsilyl protecting group

S. Sieburth, Fang Zhang, Christina B. Madsen-Duggan, 2001 .

Divergent Strategy for Diastereocontrolled Synthesis of Small- and Medium-Ring Architectures.

Ihsan A. Shehadi, S. Sieburth, T. Al‐Tel, 2020, The Journal of organic chemistry.

The [4 + 4] cycloaddition and its strategic application in natural product synthesis

S. Sieburth, N. T. Cunard, 1996 .

Fusicoccin ring system by [4+4] cycloaddition. 2. A model study

S. Sieburth, T. Al‐Tel, K. Mcgee, 1999 .

MACROEXPANSION METHODOLOGY: AN EFFICIENT EIGHT UNIT RING EXPANSION

S. Sieburth, P. Wender, 1981 .

Macroexpansion methodology : Medium ring synthesis based on an eight unit ring expansion process

S. Sieburth, Sunil Singh, J. Petraitis, 1981 .

Chemistry of Silicon‐Containing Amino Acids

S. Sieburth, Yingmei Qi, 2010 .

Silanediol Protease Inhibitors: From Conception to Validation

S. Sieburth, Chien-an Chen, 2006 .

Tether-enforced reversal of regioselectivity: head-to-head [4 + 4] photocycloaddition of 2-pyridones

S. Sieburth, B. Siegel, 1996 .

Selective Intermolecular Photo-[4 + 4]-cycloaddition with 2-Pyridone Mixtures. 2. Preparation of (1α,2β,5β,6α)-3-Butyl- 9-methoxy-3,7-diazatricyclo[4.2.2.22,5]dodeca-9,11-diene-4,8-dione

S. Sieburth, Chao Lin, D. Rucando, 1999 .

Structural analysis of silanediols as transition-state-analogue inhibitors of the benchmark metalloprotease thermolysin.

B. Matthews, S. Sieburth, D. Juers, 2005, Biochemistry.

Bioactive Amino Acids, Peptides and Peptidomimetics Containing Silicon

S. Sieburth, 2014 .

α-Trialkylsilyl Amino Acid Stability

S. Sieburth, Guodong Liu, 2005 .

Enantioselective α-Silyl Amino Acid Synthesis by Reverse-Aza-Brook Rearrangement

S. Sieburth, Guodong Liu, 2003 .

Asymmetric synthesis of alpha-amino allyl, benzyl, and propargyl silanes by metalation and rearrangement.

S. Sieburth, Jiayi Xu, H. O'hare, 2003, Organic letters.

Photo-[4+4]-cycloaddition ( para ) of meta -substituted benzenes with 2-pyridones

S. Sieburth, D. Vrubliauskas, Buddha B. Khatri, 2015 .

Polyquinanes by [4 + 4] cycloaddition-transannular cyclization.

S. Sieburth, Y. Lim, L. Kuznetsova, 2001, Organic letters.

?-Alkyl-?-aminosilanes: Synthesis via Alkylation and Hydrosilylation

S. Sieburth, H. O'hare, J. J. Somers, 1997 .

α-Alkyl-α-aminosilanes. 1. Metalation and alkylation between silicon and nitrogen

S. Sieburth, H. O'hare, J. J. Somers, 1996 .

Asymmetry by electrophilic rearrangement of symmetric 2-pyridone photodimers.

S. Sieburth, P. Carroll, J. Lauher, 2005, Organic letters.

Stereocontrol of 2-Pyridone [4 + 4] Photocycloaddition: A Thermal-Photochemical Cycle To Produce Exclusively Trans Cycloadducts

S. Sieburth, Chao Lin, 1994 .

Post-Ugi Cascade Transformations for Accessing Diverse Chromenopyrrole Collections.

S. Sieburth, R. El-Awady, T. Al‐Tel, 2018, Organic letters.

Silicon-based metalloprotease inhibitors: synthesis and evaluation of silanol and silanediol peptide analogues as inhibitors of angiotensin-converting enzyme.

S. Sieburth, M. W. Mutahi, Luxuan Guo, 2002, Journal of the American Chemical Society.

Silanediols: A New Class of Potent Protease Inhibitors.

S. Sieburth, Luxuan Guo, T. Nittoli, 1998, Angewandte Chemie.

Studies in bicyclo[3.1.0]hexane methanolysis. Ring opening of activated cyclopropanes under acidic and basic conditions.

S. Sieburth, Y. Lim, K. Mcgee, 2002, The Journal of organic chemistry.

A Quantitative NMR Method for Silyllithium Analysis

S. Sieburth, Yingjian Bo, 2017, Synlett.

An intramolecular Diels-Alder reaction of vinylsilanes

S. Sieburth, L. Fensterbank, 1992 .

Serine protease inhibition by a silanediol peptidomimetic.

S. Sieburth, Swapnil Singh, 2012, Organic letters.

Silanediol inhibitors of angiotensin-converting enzyme. Synthesis and evaluation of four diastereomers of Phe[Si]Ala dipeptide analogues.

S. Sieburth, P. Carroll, Jaeseung Kim, 2005, The Journal of organic chemistry.

Drug design with a new transition state analog of the hydrated carbonyl: silicon-based inhibitors of the HIV protease.

S. Sieburth, G. Trainor, R. Klabe, 2001, Chemistry & biology.

Efficient, enantioselective assembly of silanediol protease inhibitors.

S. Sieburth, Swapnil Singh, Cui Cao, 2011, Organic letters.

Silanediols: A New Class of Potent Protease Inhibitors.

S. Sieburth, Luxuan Guo, T. Nittoli, 1998, Angewandte Chemie.

Asymmetric Synthesis of α-Amino Allyl, Benzyl, and Propargyl Silanes by Metalation and Rearrangement.

S. Sieburth, Jiayi Xu, H. O'hare, 2003 .

Synthesis of α-alkyl-α-aminosilanes by rhodium-catalyzed hydrosilylation of Boc-protected vinyl amines

S. Sieburth, J. J. Somers, G. Hewitt, 2000 .

Silicon Mimics of Unstable Carbon

S. Sieburth, 2014 .

Fusicoccin Ring System by [4 + 4] Cycloaddition. Control of Diastereoselectivity through Hydrogen Bonding

S. Sieburth, T. Al‐Tel, K. Mcgee, 1998 .

Studies in silanol synthesis: internal nucleophiles and steric hindrance

S. Sieburth, A. Glekas, 2001 .

Tetraquinanes via [4 + 4] photocycloaddition/transannular ring closure.

S. Sieburth, P. Carroll, Peiling Chen, 2010, Organic letters.

A short synthesis of the tricyclo[3.3.21,4.0]decane ring system

Scott McN. Sieburth, S. Sieburth, Santos Elena Doval, 1994 .

Stabilization, isomerization and rearrangement of enyne [4 + 4]-cycloadducts.

S. Sieburth, Buddha B. Khatri, S. Kulyk, 2014, Organic letters.

2‐Alkenyl Carbinols from 2‐Halo Ketones: 2‐E‐Propenylcyclohexanol

D. Holt, S. Sieburth, P. Wender, 2003 .

Sequencing [4+1]-Cycloaddition and Aza-Michael Addition Reactions: A Diastereoselective Cascade for the Rapid Access of Pyrido[2',1':2,3]/Thiazolo[2',3':2,3]imidazo[1,5-a]quinolone Scaffolds as Potential Antibacterial and Anticancer Motifs.

S. Sieburth, T. Al‐Tel, V. Srinivasulu, 2019, The Journal of organic chemistry.

An enolate-accelerated Cope rearrangement

S. Sieburth, P. Wender, R. Ternansky, 1985 .

A [4 + 4] 2-pyridone approach to taxol. 3. Stereocontrol during elaboration of the cyclooctane.

S. Sieburth, J. Chen, K. Mcgee, 2000, The Journal of organic chemistry.

Beyond the medium ring: A [4 + 4] cycloaddition/fragmentation synthesis of eleven-membered rings

S. Sieburth, T. Al‐Tel, D. Rucando, 1997 .

A 2-PYRIDONE PHOTO-4 + 4 APPROACH TO THE TAXANES

S. Sieburth, Jianhao Chen, and Krishnamoorthy Ravindran, 1996 .

Enyne-2-pyrone [4 + 4]-Photocycloaddition: Sesquiterpene Synthesis and a Low-Temperature Cope Rearrangement.

S. Sieburth, Buddha B. Khatri, 2015, Organic letters.

Enyne [4 + 4] photocycloaddition with polycyclic aromatics

S. Sieburth, Buddha B. Khatri, S. Kulyk, 2014 .

Photoreactivity of 2-pyridones with furan, benzene, and naphthalene. Inter- and intramolecular photocycloadditions.

S. Sieburth, F. Zhang, K. Mcgee, 2000, The Journal of organic chemistry.

Novel reaction pathways for 2-pyridone [4+4] photoadducts.

S. Sieburth, P. Carroll, Peiling Chen, 2006, Organic letters.

TANDEM ASYMMETRIC ALKYLATION-DIECKMANN CONDENSATION

S. Sieburth, Chien-an Chen, 1995 .

Formation and isomerization of polycyclic 1,5-enynes ☆

S. Sieburth, S. Kulyk, Paul B. Finn, 2015 .

Organosilane insecticides. Part II: Chemistry and structure—activity relationships

S. Sieburth, Charles N. Langevine, D. M. Dardaris, 1990 .

2,2,2‐Trichloro‐t‐butoxycarbonyl Chloride

S. Sieburth, E. D. Santos, 2001 .

Intermolecularly selective [4+4] photocycloaddition of 2-pyridone mixtures

S. Sieburth, Chao Lin, 1996 .

α-Alkyl-α-aminosilanes. 2. A2H NMR study of organolithium stabilization by silicon and by phenyl in solution

S. Sieburth, J. J. Somers, 1996 .

New insecticides by replacement of carbon by other Group IV elements

S. Sieburth, Sarah Y. Lin, T. Cullen, 1990 .

Organosilane insecticides. Part I: Biological and physical effects of isosteric replacement of silicon for carbon in etofenprox and MTI‐800

S. Sieburth, D. Gammon, C. Manly, 1990 .

A silanediol inhibitor of the metalloprotease thermolysin: synthesis and comparison with a phosphinic acid inhibitor.

S. Sieburth, Jaeseung Kim, 2004, The Journal of organic chemistry.

Silanediol peptidomimetics. Evaluation of four diastereomeric ACE inhibitors.

S. Sieburth, Jaeseung Kim, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and properties of a sterically unencumbered δ-silanediol amino acid.

S. Sieburth, Jin Kyung Kim, 2012, The Journal of organic chemistry.

Silanol synthesis: reaction of hexaphenylcyclotrisiloxane with organometallic reagents

S. Sieburth, Weilin Mu, 1993 .

Boat versus half-chair cyclohexyl rings: determinants of conformational preference

S. Sieburth, 1994 .

A Practical Synthesis of Difunctional Organosilane Reagents and Their Application to the Diels-Alder Reaction.

S. Sieburth, J. Lang, 1999, The Journal of organic chemistry.

Practical method for .alpha.-alkenyl ketone synthesis based on a facile reductive rearrangement of alkynyl halohydrins

D. Holt, S. Sieburth, P. Wender, 1983 .

The Inter- and Intramolecular [4 + 4] Photocycloaddition of 2-Pyridones and Its Application to Natural Product Synthesis

S. Sieburth, 1999 .

PRACTICAL METHOD FOR α‐ALKENYL KETONE SYNTHESIS BASED ON A FACILE REDUCTIVE REARRANGEMENT OF ALKYNYL HALOHYDRINS

D. Holt, S. Sieburth, P. Wender, 1983 .

Drug development post COVID-19 pandemic: toward a better system to meet current and future global health challenges

S. Sieburth, T. Al‐Tel, D. Zaher, 2020, Expert opinion on drug discovery.

Enyne [4+4] Cycloaddition/Oxidation: Ring Contraction via Cyclopropanones and Their Anionic Ring-Opening Reactions.

S. Sieburth, Buddha B. Khatri, S. Kulyk, 2017, Angewandte Chemie.

Intramolecular pyridone/enyne photocycloaddition: partitioning of the [4 + 4] and [2 + 2] pathways.

Michael J. Zdilla, S. Sieburth, W. Dougherty, 2011, Organic Letters.

Enyne [4 + 4] photocycloaddition: bridged 1,2,5-cyclooctatrienes.

S. Sieburth, W. Dougherty, S. Fleming, 2010, Organic letters.

Intramolecular photocycloaddition of 1,3-dienes with 2-pyridones

S. Sieburth, Fang Zhang, 1999 .

Evidence for helicity in insect diuretic peptide hormones: computational analysis, spectroscopic studies, and biological assays.

S. Sieburth, G. Coast, T. Nittoli, 1999, The journal of peptide research : official journal of the American Peptide Society.

Divergent Protocol for the Synthesis of Isoquinolino[1,2-b]quinazolinone and Isoquinolino[2,1-a]quinazolinone Derivatives.

S. Sieburth, T. Al‐Tel, M. El-Gamal, 2023, The Journal of organic chemistry.

Multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds

S. Sieburth, T. Al‐Tel, V. Srinivasulu, 2018, Nature Communications.

A photochemical [4 + 4] method for the construction of annulated eight-membered rings

S. Sieburth, Jian Long Chen, 1991 .