Michael Müller

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MenD as a versatile catalyst for asymmetric synthesis

Anja Kurutsch, M. Richter, V. Brecht, 2009 .

Mathematical model of the MenD-catalyzed 1,4-addition (Stetter reaction) of α-ketoglutaric acid to acrylonitrile.

Michael Müller, M. Sudar, Đ. Vasić-Rački, 2018, Journal of biotechnology.

Chorismatase Mechanisms Reveal Fundamentally Different Types of Reaction in a Single Conserved Protein Fold.

K. Diederichs, Michael Müller, W. Welte, 2015, Journal of the American Chemical Society.

Monomeric Dihydroanthraquinones: A Chemoenzymatic Approach and its (Bio)synthetic Implications for Bisanthraquinones.

S. Singh, Michael Müller, A. Mondal, 2018, Chemistry.

Reversible biological Birch reduction at an extremely low redox potential.

Michael Müller, W. Hagen, S. Baumann, 2010, Journal of the American Chemical Society.

Tuning and Switching Enantioselectivity of Asymmetric Carboligation in an Enzyme through Mutational Analysis of a Single Hot Spot

Michael Müller, P. Neumann, R. Ficner, 2015, Chembiochem : a European journal of chemical biology.

Initial Steps in the Anoxic Metabolism of Cholesterol by the Denitrifying Sterolibacterium denitrificans*♦

Michael Müller, Yin-Ru Chiang, G. Fuchs, 2007, Journal of Biological Chemistry.

Mechanism of enzymatic Birch reduction: stereochemical course and exchange reactions of benzoyl-CoA reductase.

Michael Müller, B. Golding, M. Boll, 2008, Journal of the American Chemical Society.

Aromatizing Cyclohexa-1,5-diene-1-carbonyl-Coenzyme A Oxidase

Michael Müller, N. Jehmlich, M. von Bergen, 2008, Journal of Biological Chemistry.

Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: The ethylmalonyl-CoA pathway

V. Brecht, Michael Müller, G. Fuchs, 2007, Proceedings of the National Academy of Sciences.

Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus

Michael Müller, Georg Fuchs, V. Brecht, 2009, Proceedings of the National Academy of Sciences.

Extended substrate range of thiamine diphosphate-dependent MenD enzyme by coupling of two C–C-bonding reactions

G. Sprenger, Michael Müller, Matthias Schapfl, 2018, Applied Microbiology and Biotechnology.

A New Screen for Combinatorial Catalysis; On-Bead Testing in Agarose Gel.

Michael Müller, A. P. Davis, Trevor W. Mathers, 2001, Angewandte Chemie.

Tautomers of anthrahydroquinones: enzymatic reduction and implications for chrysophanol, monodictyphenone, and related xanthone biosyntheses.

Michael Müller, S. M. Husain, Michael A. Schaetzle, 2012, Journal of the American Chemical Society.

Extended Catalytic Scope of a Well‐Known Enzyme: Asymmetric Reduction of Iminium Substrates by Glucose Dehydrogenase

Michael Müller, S. Lüdeke, D. Wetzl, 2017, Chembiochem : a European journal of chemical biology.

ATP-dependent hydroxylation of an unactivated primary carbon with water

Michael Müller, C. Jacoby, M. Boll, 2020, Nature Communications.

Asymmetric Synthesis and Biological Evaluation of Glycosidic Prodrugs for a Selective Cancer Therapy

Michael Müller, L. Tietze, F. Alves, 2008, ChemMedChem.

Concave Reagents. 2 Macrobicyclic 1,10‐Phenanthrolines

Michael Müller, U. Lüning, 1989 .

Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase

V. Brecht, Michael Müller, G. Fuchs, 2009, Proceedings of the National Academy of Sciences.

Enantioselective Enzymatic Naphthoyl Ring Reduction.

Michael Müller, S. Lüdeke, Sebastian Estelmann, 2018, Chemistry.

Ibotenic Acid Biosynthesis in the Fly Agaric Is Initiated by Glutamate Hydroxylation†

Michael Müller, Sebastian Obermaier, 2019, bioRxiv.

Enantioselective Phenol Coupling by Laccases in the Biosynthesis of Fungal Dimeric Naphthopyrones.

Michael Müller, Sebastian Obermaier, Wiebke Thiele, 2019, Angewandte Chemie.

Exploiting the Catalytic Diversity of Short‐Chain Dehydrogenases/Reductases: Versatile Enzymes from Plants with Extended Imine Substrate Scope

Michael Müller, T. Kutchan, Sebastian Roth, 2018, Chembiochem : a European journal of chemical biology.

Identification and characterization of 2‐naphthoyl‐coenzyme A reductase, the prototype of a novel class of dearomatizing reductases

C. Eberlein, Michael Müller, M. von Bergen, 2013, Molecular microbiology.

25-Hydroxyvitamin D3 Synthesis by Enzymatic Steroid Side-Chain Hydroxylation with Water.

Michael Müller, N. Jehmlich, Tobias Jung, 2016, Angewandte Chemie.

Biocatalytic One-Carbon Transfer – A Review

Michael Müller, J. Andexer, Philipp Germer, 2022, Synthesis.

Thiamine-Dependent Enzymes as Catalysts of C–C Bond-Forming Reactions: The Role of ‘‘ Orphan’’ ’’ Enzymes

G. Sprenger, Michael Müller, 2003 .

ATP-Dependent C–F Bond Cleavage Allows the Complete Degradation of 4-Fluoroaromatics without Oxygen

Michael Müller, N. Jehmlich, M. von Bergen, 2016, mBio.

A new perspective on thiamine catalysis.

G. Sprenger, Michael Müller, M. Pohl, 2004, Current opinion in biotechnology.

(S,S)-2,3-Dihydroxy-2,3-dihydrobenzoic acid: microbial access with engineered cells of Escherichia coli and application as starting material in natural-product synthesis.

R. Takors, G. Sprenger, Michael Müller, 2003, Chemistry.

Regio- and stereoselective oxidative phenol coupling in Aspergillus niger.

Michael Müller, S. Günther, A. Brakhage, 2012, Angewandte Chemie.

Synthesis of Functionalized Cyclohexadiene-trans-Diols with Recombinant Cells of Escherichia coli.

G. Sprenger, Michael Müller, D. Franke, 2001, Angewandte Chemie.

Biocatalytic production of enantiopure cyclohexane-trans-1,2-diol using extracellular lipases from Bacillus subtilis

Michael Müller, S. Lütz, T. Eggert, 2006, Applied Microbiology and Biotechnology.

The second step of the halogen/metal exchange reaction.

R. W. Hoffmann, Michael Müller, M. Brönstrup, 2003, Organic letters.

Development of a donor-acceptor concept for enzymatic cross-coupling reactions of aldehydes: the first asymmetric cross-benzoin condensation.

Martina Pohl, Michael Müller, Martin Baumann, 2002, Journal of the American Chemical Society.

Determination of the Nucleophilicities of Silyl and Alkyl Enol Ethers

Michael Müller, H. Mayr, M. Patz, 1998 .

Side chain thiol-functionalized poly(ethylene glycol) by post-polymerization modification of hydroxyl groups: synthesis, crosslinking and inkjet printing

Michael Müller, G. Tovar, E. Hoch, 2014 .

Asymmetric total synthesis of (-)-callystatin A employing the SAMP/RAMP hydrazone alkylation methodology.

Michael Müller, D. Enders, J. Vicario, 2002, Organic letters.

Biocatalytic Properties and Structural Analysis of Phloroglucinol Reductases.

Michael Müller, S. Gerhardt, O. Einsle, 2016, Angewandte Chemie.

Concave Reagents, 5 Bimacrocyclic 1,10‐Phenanthroline Cyclophanes

Michael Müller, U. Lüning, 1990 .

Regio‐ and Stereoselective Intermolecular Oxidative Phenol Coupling in Kotanin Biosynthesis by Aspergillus Niger

Michael Müller, Wolfgang Hüttel, 2007, Chembiochem : a European journal of chemical biology.

Tetrahydroxynaphthalene reductase: catalytic properties of an enzyme involved in reductive asymmetric naphthol dearomatization.

M. Richter, Michael Müller, S. Günther, 2012, Angewandte Chemie.

Enzymatic Formation of Rufoschweinitzin, a Binaphthalene from the Basidiomycete Cortinarius rufoolivaceus

Michael Müller, W. Steglich, Wiebke Thiele, 2020, Chembiochem : a European journal of chemical biology.

Chorismate- and isochorismate converting enzymes: versatile catalysts acting on an important metabolic node.

Michael Müller, Florian Hubrich, J. Andexer, 2021, Chemical communications.

Expanding the Imine Reductase Toolbox by Exploring the Bacterial Protein‐Sequence Space

Michael Müller, M. Ebeling, D. Wetzl, 2015, Chembiochem : a European journal of chemical biology.

Efficient Asymmetric Syntheses of (+)-Strictifolione

Michael Müller, D. Enders, A. Lenzen, 2004 .

Enantioselective intermolecular aldehyde-ketone cross-coupling through an enzymatic carboligation reaction.

M. Richter, Michael Müller, Hung‐wen Liu, 2010, Angewandte Chemie.

Evidence for an iodine ate complex as an observable intermediate in the iodine/magnesium exchange on a 1,1-diiodoalkane

R. W. Hoffmann, Michael Müller, M. Brönstrup, 2003 .

Thiamin diphosphate in biological chemistry: exploitation of diverse thiamin diphosphate‐dependent enzymes for asymmetric chemoenzymatic synthesis

Michael Müller, M. Pohl, D. Gocke, 2009, The FEBS journal.

Chiral organometallic reagents. Part XXIV.1 Iodine ate-complexes as intermediates in the iodine–lithium exchange reaction on 1,1-diiodoalkanes

R. W. Hoffmann, Michael Müller, M. Brönstrup, 1999 .

BIOTECHNOLOGICALLY RELEVANT ENZYMES AND PROTEINS Asymmetric Stetter reactions catalyzed by thiamine diphosphate-dependent enzymes

M. Richter, Michael Müller, S. Andrade, 2014 .

A Short Olefin Metathesis-Based Route to Enantiomerically Pure Arylated Dihydropyrans and α,β-Unsaturated δ-Valero Lactones

Michael Müller, B. Schmidt, P. Dünkelmann, 2003 .

Enzymatic spiroketal formation via oxidative rearrangement of pentangular polyketides

Michael Müller, J. Piel, S. Lüdeke, 2021, Nature Communications.

Enzymatic Chemoselective Aldehyde-Ketone Cross-Couplings through the Polarity Reversal of Methylacetoin.

Michael Müller, L. Lerin, O. Bortolini, 2015, Angewandte Chemie.

CC bond formation using ThDP-dependent lyases.

G. Sprenger, Michael Müller, M. Pohl, 2013, Current opinion in chemical biology.

Substrate‐Determined Diastereoselectivity in an Enzymatic Carboligation

Michael Müller, L. Nafie, S. Lüdeke, 2016, Chembiochem : a European journal of chemical biology.

Concave Reagents, 4 Protonation of Nitronate Anions via concave Pyridines. Stereoselective C‐Protonation versus Nef Reaction

Michael Müller, R. Baumstark, Ulrich Lünig, 1990 .

Concave Reagents, 15[1]. New Concave 1,10‐Phenanthrolines: Catalysts for the Alcohol Addition to Ketenes and Ligands in Transition Metal Complexes

Michael Müller, K. Peters, U. Lüning, 1994 .

Concave reagents, 8. Concave pyridines and 1,10‐phenanthrolines with sulfonamide bridgeheads. Increased basicity by 4‐diethylamino substitution of the pyridine unit

Michael Müller, U. Lüning, R. Baumstark, 1991 .

On the Mechanism and Stereoselectivity of the Copper(I)‐Catalyzed Cyclopropanation of Olefins − A Combined Experimental and Density Functional Study

Michael Müller, F. Löffler, Frank Terstegen, 2001 .

The Molecular and Electronic Structure of Symmetrically and Asymmetrically Coordinated, Non‐Heme Iron Complexes Containing [FeIII(μ‐N)FeIV]4+ (S=3/2) and [FeIV(μ‐N)FeIV]5+ (S=0) Cores

K. Wieghardt, Michael Müller, P. Hildebrandt, 1999 .

Molecular and electronic structure of a mixed-valent class II,dinuclear complex containing a linear[FeII–O–FeIII]3+core

K. Wieghardt, Michael Müller, E. Bill, 1997 .

An anthrone, an anthraquinone and two oxanthrones from Kniphofia foliosa

Michael Müller, W. Steglich, A. Yenesew, 1994 .

Catalytic Alkylation Using a Cyclic S-Adenosylmethionine Regeneration System.

Michael Richter, Michael Müller, M. Richter, 2017, Angewandte Chemie.

Asymmetric synthesis of aliphatic 2-hydroxy ketones by enzymatic carboligation of aldehydes

Michael Müller, P. D. D. María, H. Gröger, 2007 .

Benzaldehyde lyase-catalyzed enantioselective carboligation of aromatic aldehydes with mono- and dimethoxy acetaldehyde.

Michael Müller, A. Demir, Ozge Seşenoğlu, 2003, Organic letters.

Biomimetic asymmetric synthesis of (R)-GTRI-02 and (3S,4R)-3,4-dihydroxy-3,4-dihydronaphthalen-1(2H)-ones.

Michael Müller, S. Lüdeke, S. M. Husain, 2012, Organic letters.

Terpenes from the Soft Corals Litophyton arboreum and Sarcophyton ehrenbergi

Michael Müller, K. Seifert, K. Shaker, 2010, Chemistry & biodiversity.

Diastereomer-differentiating hydrolysis of 1,3-diol-acetonides: a simplified procedure for the separation of syn- and anti-1,3-diols.

Michael Müller, M. Wolberg, S. Bode, 2002, Organic letters.

Diversity in Reduction with Short‐Chain Dehydrogenases: Tetrahydroxynaphthalene Reductase, Trihydroxynaphthalene Reductase, and Glucose Dehydrogenase

Michael Müller, S. M. Husain, David Conradt, 2015 .

Crossing the Border: From Keto‐ to Imine Reduction in Short‐Chain Dehydrogenases/Reductases

Michael Müller, J. Pleiss, K. Tittmann, 2020, Chembiochem : a European journal of chemical biology.

Structural and Mutagenesis Studies of the Thiamine‐Dependent, Ketone‐Accepting YerE from Pseudomonas protegens

G. Schneider, M. Richter, Michael Müller, 2018, Chembiochem : a European journal of chemical biology.

Conversion of pyruvate decarboxylase into an enantioselective carboligase with biosynthetic potential.

Michael Müller, K. Tittmann, M. Pohl, 2011, Journal of the American Chemical Society.

Regio- and Stereoselective Aliphatic-Aromatic Cross-Benzoin Reaction: Enzymatic Divergent Catalysis.

Dörte Rother, Martina Pohl, Michael Müller, 2016, Chemistry.

S‐Selective Mixed Carboligation by Structure‐Based Design of the Pyruvate Decarboxylase from Acetobacter pasteurianus

G. Schneider, Michael Müller, J. Pleiss, 2011 .

Rational Protein Design of ThDP‐Dependent Enzymes—Engineering Stereoselectivity

G. Schneider, Michael Müller, J. Pleiss, 2008, Chembiochem : a European journal of chemical biology.

TCA cycle involved enzymes SucA and Kgd, as well as MenD: efficient biocatalysts for asymmetric C-C bond formation.

L. Eggeling, G. Sprenger, Michael Müller, 2013, Organic letters.

Enzymatic synthesis of - and sedoheptulose 7-phosphate and ido-heptulose 7-phosphate

Michael Müller, A. Kirschning, H. Floss, 1999 .

Nitroreductase‐Mediated Release of Inhibitors of Lysine‐Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells†

Michael Müller, M. Lübbert, R. Schüle, 2019, Chembiochem : a European journal of chemical biology.

Regio- and stereoselective intermolecular phenol coupling enzymes in secondary metabolite biosynthesis.

Michael Müller, Wolfgang Hüttel, 2020, Natural product reports.

Towards semisynthetic natural compounds with a biaryl axis: Oxidative phenol coupling in Aspergillus niger.

Michael Müller, K. Hugentobler, 2017, Bioorganic & medicinal chemistry.

Mutational Analysis and Reconstituted Expression of the Biosynthetic Genes Involved in the Formation of 3-Amino-5-hydroxybenzoic Acid, the Starter Unit of Rifamycin Biosynthesis in Amycolatopsis mediterraneiS699*

Michael Müller, R. Müller, E. Leistner, 2001, The Journal of Biological Chemistry.

Regio- and stereoselective intermolecular oxidative phenol coupling in Streptomyces.

Stefan Günther, Michael Richter, Michael Müller, 2014, Journal of the American Chemical Society.

Diversity in Fungal Intermolecular Phenol Coupling of Polyketides: Regioselective Laccase‐Based Systems

Michael Müller, Sebastian Obermaier, Wiebke Thiele, 2019, Chembiochem : a European journal of chemical biology.

Alteration of the Route to Menaquinone towards Isochorismate‐Derived Metabolites

Patrick C. F. Buchholz, G. Sprenger, Michael Müller, 2019, Chembiochem : a European journal of chemical biology.

Unifying Scheme for the Biosynthesis of Acyl‐Branched Sugars: Extended Substrate Scope of Thiamine‐Dependent Enzymes

Michael Müller, P. Clapés, K. Hernández, 2022, Angewandte Chemie.

New Stetter reactions catalyzed by thiamine diphosphate dependent MenD from E. coli.

Michael Müller, Mostafa Zarei, Michael Müller, 2014, Journal of biotechnology.

Monodictyochromes A and B, dimeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis.

Michael Müller, C. Gerhäuser, S. Kehraus, 2008, Journal of natural products.

Insights into the Role of Ketoreductases in the Biosynthesis of Partially Reduced Bacterial Aromatic Polyketides*

Michael Müller, A. Bechthold, A. Präg, 2019, Chembiochem : a European journal of chemical biology.

Asymmetric C-Alkylation by the S-Adenosylmethionine-Dependent Methyltransferase SgvM.

Michael Müller, J. Andexer, Silja Mordhorst, 2017, Angewandte Chemie.

A Fasciclin Protein Is Essential for Laccase-Mediated Selective Phenol Coupling in Sporandol Biosynthesis.

Michael Müller, Sebastian Obermaier, Wiebke Thiele, 2020, ACS chemical biology.

Biaryl-Forming Enzymes from Aspergilli Exhibit Substrate-Dependent Stereoselectivity.

Michael Müller, Sebastian Obermaier, 2019, Biochemistry.

Asymmetric Synthesis of Natural cis-Dihydroarenediols Using Tetrahydroxynaphthalene Reductase and Its Biosynthetic Implications.

Michael Müller, N. Saha, S. Husain, 2019, Organic letters.

Phylogenetic Studies, Gene Cluster Analysis, and Enzymatic Reaction Support Anthrahydroquinone Reduction as the Physiological Function of Fungal 17β‐Hydroxysteroid Dehydrogenase

S. Singh, Michael Müller, T. Rižner, 2017, Chembiochem : a European journal of chemical biology.

Diversity-oriented production of metabolites derived from chorismate and their use in organic synthesis.

R. Takors, M. Wubbolts, Anja Kurutsch, 2011, Angewandte Chemie.

Unprecedented Mushroom Polyketide Synthases Produce the Universal Anthraquinone Precursor

Michael Müller, D. Hoffmeister, Markus Gressler, 2022, Angewandte Chemie.

Misincorporation of dNTPs opposite 1,N2-ethenoguanine and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1,2-a]purine in oligonucleotides by Escherichia coli polymerases I exo- and II exo-, T7 polymerase exo-, human immunodeficiency virus-1 reverse transcriptase, and rat polymerase beta.

Michael Müller, F. Guengerich, S. Langouët, 1997, Biochemistry.

Misincorporation of nucleotides opposite five-membered exocyclic ring guanine derivatives by escherichia coli polymerases in vitro and in vivo: 1,N2-ethenoguanine, 5,6,7,9-tetrahydro-9-oxoimidazo[1, 2-a]purine, and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1, 2-a]purine.

L. Marnett, Michael Müller, F. Guengerich, 1998, Biochemistry.

Extended substrate range of thiamine diphosphate-dependent MenD enzyme by coupling of two C–C-bonding reactions

G. Sprenger, Michael Müller, Matthias Schapfl, 2018, Applied Microbiology and Biotechnology.

Regioselective synthesis of isotopically labeled Δ9-tetrahydrocannabinolic acid A (THCA-A-D3) by reaction of Δ9-tetrahydrocannabinol-D3 with magnesium methyl carbonate.

Michael Müller, V. Auwärter, A. Wohlfarth, 2012, Forensic science international.

Catalytic Alkylation Using a Cyclic S-Adenosylmethionine Regeneration System.

M. Richter, Michael Müller, J. Andexer, 2017, Angewandte Chemie.

Conversion of pyruvate decarboxylase into an enantioselective carboligase with biosynthetic potential.

Michael Müller, K. Tittmann, M. Pohl, 2011, Journal of the American Chemical Society.