B. Nare

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The Roles of Pteridine Reductase 1 and Dihydrofolate Reductase-Thymidylate Synthase in Pteridine Metabolism in the Protozoan Parasite Leishmania major*

L. Hardy, B. Nare, S. Beverley, 1997, The Journal of Biological Chemistry.

Evaluation of a Cyclic GMP-Dependent Protein Kinase Inhibitor in Treatment of Murine Toxoplasmosis: Gamma Interferon Is Required for Efficacy

B. Nare, P. Liberator, R. Donald, 2002, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis

B. Nare, N. Yarlett, C. Bacchi, 2013, Parasitology.

2,4-Diaminopyrimidines as Potent Inhibitors of Trypanosoma brucei and Identification of Molecular Targets by a Chemical Proteomics Approach

B. Nare, N. Yarlett, C. Bacchi, 2011, PLoS neglected tropical diseases.

Inhibitors of casein kinase 1 block the growth of Leishmania major promastigotes in vitro.

B. Nare, R. Hendrickson, P. Liberator, 2006, International journal for parasitology.

Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond Citation

Alessandro, Serge, Tyler B. Hughes, 2016 .

Use of Rodent Models in the Discovery of Novel Anthelmintics

K. Powell, B. Nare, A. Sluder, 2012 .

Purification and Molecular Characterization of cGMP-dependent Protein Kinase from Apicomplexan Parasites

Jeffrey Yuan, D. Schmatz, B. Nare, 2002, The Journal of Biological Chemistry.

Novel pyrrolobenzoxaboroles: design, synthesis, and biological evaluation against Trypanosoma brucei.

B. Nare, Huchen Zhou, Qingqing Meng, 2014, European journal of medicinal chemistry.

Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis

K. Jarnagin, B. Nare, R. Brun, 2010, Antimicrobial Agents and Chemotherapy.

Discovery of novel benzoxaborole-based potent antitrypanosomal agents.

Yaxue Zhao, B. Nare, J. McKerrow, 2010, ACS medicinal chemistry letters.

State of the art in African trypanosome drug discovery.

M. Phillips, B. Nare, R. Jacobs, 2011, Current topics in medicinal chemistry.

Application of a resazurin-based high-throughput screening assay for the identification and progression of new treatments for human African trypanosomiasis.

B. Nare, Luke Mercer, R. Don, 2012, International journal for parasitology. Drugs and drug resistance.

SAR of 2-amino and 2,4-diamino pyrimidines with in vivo efficacy against Trypanosoma brucei.

B. Nare, N. Yarlett, C. Bacchi, 2011, Bioorganic & medicinal chemistry letters.

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Manuel Llinás, George Papadatos, Sundari Suresh, 2016, PLoS pathogens.

Highly substituted terphenyls as inhibitors of parasite cGMP-dependent protein kinase activity.

Ziqiang Guan, Javier Collado, B. Nare, 2006, Journal of natural products.

Biochemical and Genetic Tests for Inhibitors ofLeishmaniaPteridine Pathways

L. Hardy, B. Nare, S. Beverley, 1997 .

Chalcone-benzoxaborole hybrid molecules as potent antitrypanosomal agents.

B. Nare, Huchen Zhou, Dazhong Ding, 2012, Journal of medicinal chemistry.

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis

B. Nare, Jennifer L Owens, R. Brun, 2011, PLoS neglected tropical diseases.

Elucidation of DnaE as the Antibacterial Target of the Natural Product, Nargenicin.

B. Nare, F. Vicente, D. Wisniewski, 2015, Chemistry & biology.

Targeting Lysine Deacetylases (KDACs) in Parasites

Garland R. Marshall, Bruce A. Rosa, Makedonka Mitreva, 2015, PLoS neglected tropical diseases.

Biosynthesis and catabolism of mannitol is developmentally regulated in the protozoan parasite Eimeria tenella.

D. Schmatz, B. Nare, R. Myers, 1999, The Journal of parasitology.

p-Azidosalicyl-5-amino-6-phenoxybenzimidazole Photolabels the N-terminal 63103 Amino Acids of Haemonchus contortus -Tubulin 1 (*)

B. Nare, E. Georges, R. Prichard, 1996, The Journal of Biological Chemistry.

Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)

B. Nare, M. Witty, R. Brun, 2018, Bioorganic & medicinal chemistry letters.

Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT).

R. Barker, M. Phillips, B. Nare, 2009, Bioorganic & medicinal chemistry letters.

MK-4815, a Potential New Oral Agent for Treatment of Malaria

D. Schmatz, B. Nare, P. Liberator, 2012, Antimicrobial Agents and Chemotherapy.

Anticoccidial kinase inhibitors: identification of protein kinase targets secondary to cGMP-dependent protein kinase.

B. Nare, P. Liberator, R. Donald, 2006, Molecular and biochemical parasitology.

Toxoplasma gondii Cyclic GMP-Dependent Kinase: Chemotherapeutic Targeting of an Essential Parasite Protein Kinase

B. Nare, Suresh B. Singh, P. Liberator, 2002, Eukaryotic Cell.

Development of a scintillation proximity assay for histone deacetylase using a biotinylated peptide derived from histone-H4.

M. Bednarek, D. Schmatz, B. Nare, 1999, Analytical biochemistry.

New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity

L. Hardy, B. Nare, S. Beverley, 1997, Parasitology.

PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major

L. Garraway, T. Vickers, B. Nare, 2009, Current Genetics.

Synergy between dinotefuran and fipronil against the cat flea (Ctenocephalides felis): improved onset of action and residual speed of kill in adult cats

B. Nare, H. Karembé, M. Varloud, 2017, Parasites & Vectors.

NITROPHENIDE (MEGASUL™) BLOCKS EIMERIA TENELLA DEVELOPMENT BY INHIBITING THE MANNITOL CYCLE ENZYME MANNITOL-1-PHOSPHATE DEHYDROGENASE

D. Schmatz, B. Nare, R. Myers, 2001, Journal of Parasitology.

Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents.

Yaxue Zhao, B. Nare, Dawei Li, 2011, Journal of medicinal chemistry.

Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis.

B. Nare, N. Yarlett, M. Orr, 2011, Future medicinal chemistry.

Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways.

L. Hardy, B. Nare, S. Beverley, 1997, Experimental parasitology.

Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity.

B. Nare, Z. Guan, P. Liberator, 2005, Journal of natural products.

DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis

I. Gilbert, V. Yardley, B. Nare, 2021, Journal of medicinal chemistry.

PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major.

L. Hardy, B. Nare, S. Beverley, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: stereochemical and kinetic evidence.

L. Hardy, K. Anderson, B. Nare, 1998, Biochemistry.

Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT).

B. Nare, B. Hirth, C. Celatka, 2009, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Structure−Activity Relationship of Trypanosoma brucei Leucyl-tRNA Synthetase Inhibitors as Antitrypanosomal Agents

Yaxue Zhao, B. Nare, Dawei Li, 2011 .