L. Spyracopoulos

发表

Structural basis of prion inhibition by phenothiazine compounds.

A. Aguzzi, M. James, P. K. Baral, 2014, Structure.

Interaction of cardiac troponin C with Ca(2+) sensitizer EMD 57033 and cardiac troponin I inhibitory peptide.

B. Sykes, L. Spyracopoulos, J. Putkey, 2000, Biochemistry.

Increased precision for analysis of protein–ligand dissociation constants determined from chemical shift titrations

L. Spyracopoulos, C. J. Markin, Craig J Markin, 2012, Journal of biomolecular NMR.

Structure of the C-domain of Human Cardiac Troponin C in Complex with Ca2+ Sensitizer EMD 57033

B. Sykes, L. Spyracopoulos, R. Solaro, 2001 .

Molecular Basis for K63-Linked Ubiquitination Processes in Double-Strand DNA Break Repair: A Focus on Kinetics and Dynamics.

L. Spyracopoulos, M. Hendzel, Michael J Hendzel, 2017, Journal of molecular biology.

A mutation in the catalytic loop of Hsp90 specifically impairs ATPase stimulation by Aha1p, but not Hch1p.

L. Spyracopoulos, P. LaPointe, J. Knowles, 2014, Journal of molecular biology.

Two Mms2 residues cooperatively interact with ubiquitin and are critical for Lys63 polyubiquitination in vitro and in vivo

W. Xiao, L. Spyracopoulos, Landon Pastushok, 2007, FEBS letters.

Calcium-induced structural transition in the regulatory domain of human cardiac troponin C.

B D Sykes, B. Sykes, S. Sia, 1997, Biochemistry.

NMR studies of Ca2+ binding to the regulatory domains of cardiac and E41A skeletal muscle troponin C reveal the importance of site I to energetics of the induced structural changes.

L. Spyracopoulos, S. Gagné, L. Smillie, 1997, Biochemistry.

Thermodynamic interpretation of protein dynamics from NMR relaxation measurements.

L. Spyracopoulos, 2005, Protein and peptide letters.

Structure of an allosteric inhibitor of LFA-1 bound to the I-domain studied by crystallography, NMR, and calorimetry.

T. Ceska, L. Spyracopoulos, M. Robinson, 2004, Biochemistry.

Energetics and specificity of interactions within Ub.Uev.Ubc13 human ubiquitin conjugation complexes.

W. Xiao, L. Spyracopoulos, S. McKenna, 2003, Biochemistry.

Active Site Gate Dynamics Modulate the Catalytic Activity of the Ubiquitination Enzyme E2-25K

W. Xiao, M. Rout, L. Spyracopoulos, 2018, Scientific Reports.

Backbone dynamics of receptor binding and antigenic regions of a Pseudomonas aeruginosa pilin monomer.

B. Sykes, L. Spyracopoulos, R. Irvin, 2001, Biochemistry.

NMR Studies of Protein Sidechain Dynamics

W. Gronwald, L. Kay, B. Sykes, 1998 .

Dynamics-Derived Insights into Complex Formation between the CXCL8 Monomer and CXCR1 N-Terminal Domain: An NMR Study

L. Spyracopoulos, K. Rajarathnam, P. R. B. Joseph, 2018, Molecules.

Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C.

B. Sykes, L. Spyracopoulos, M. X. Li, 1999, Biochemistry.

Solution Structure of the Human Ubiquitin-conjugating Enzyme Variant Uev1a

W. Xiao, D. Hau, L. Spyracopoulos, 2006 .

Structure and interactions of the ubiquitin-conjugating enzyme variant human Uev1a: implications for enzymatic synthesis of polyubiquitin chains.

W. Xiao, D. Hau, L. Spyracopoulos, 2006, Biochemistry.

Backbone dynamics of the human cc chemokine eotaxin: Fast motions, slow motions, and implications for receptor binding

B. Sykes, L. Spyracopoulos, Key‐Sun Kim, 1999, Protein science : a publication of the Protein Society.

NMR Analysis of Type III Antifreeze Protein Intramolecular Dimer

L. Spyracopoulos, H. Kondo, S. Tsuda, 2001, The Journal of Biological Chemistry.

Backbone dynamics of an alamethicin in methanol and aqueous detergent solution determined by heteronuclear 1H−15N NMR spectroscopy

L. Spyracopoulos, A. Yee, J. O'Neil, 1996, Journal of biomolecular NMR.

RYBP Is a K63-Ubiquitin-Chain-Binding Protein that Inhibits Homologous Recombination Repair.

L. Spyracopoulos, M. Hendzel, H. Strickfaden, 2018, Cell reports.

Structure of Cardiac Muscle Troponin C Unexpectedly Reveals a Closed Regulatory Domain*

B. Sykes, S. Sia, L. Spyracopoulos, 1997, The Journal of Biological Chemistry.

Role of Polyubiquitin Chain Flexibility in the Catalytic Mechanism of Cullin-RING Ubiquitin Ligases.

P. Mercier, L. Spyracopoulos, C. Markin, 2019, The journal of physical chemistry. B.

Dynamics of the RING domain from human TRAF6 by 15N NMR spectroscopy: implications for biological function.

L. Spyracopoulos, C. Markin, L. F. Saltibus, 2008, Biochemistry.

Structure, interactions, and dynamics of the RING domain from human TRAF6

W. Xiao, P. Mercier, D. Hau, 2007, Protein science : a publication of the Protein Society.

UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53

S. Pomeroy, K. Nakayama, L. Spyracopoulos, 2011, Nature Medicine.

Ubc13: the Lys63 ubiquitin chain building machine

J. Glover, L. Spyracopoulos, C. D. Hodge, 2016, Oncotarget.

Noncovalent Interaction between Ubiquitin and the Human DNA Repair Protein Mms2 Is Required for Ubc13-mediated Polyubiquitination*

W. Xiao, L. Spyracopoulos, C. Ptak, 2001, The Journal of Biological Chemistry.

Spruce budworm antifreeze protein: changes in structure and dynamics at low temperature.

B. Sykes, L. Spyracopoulos, Z. Jia, 2003, Journal of molecular biology.

Structure and dynamics of a beta-helical antifreeze protein.

B. Sykes, L. Spyracopoulos, Z. Jia, 2002, Biochemistry.

Structure and Dynamics of a -Helical Antifreeze Protein ,

B. Sykes, L. Spyracopoulos, Z. Jia, 2002 .

Molecular Basis for Phosphorylation-dependent SUMO Recognition by the DNA Repair Protein RAP80*

Anamika, L. Spyracopoulos, 2015, The Journal of Biological Chemistry.

Catalytic proficiency of ubiquitin conjugation enzymes: balancing pK(a) suppression, entropy, and electrostatics.

W. Xiao, L. Spyracopoulos, C. Markin, 2010, Journal of the American Chemical Society.

Nucleotide Binding and Active Site Gate Dynamics for the Hsp90 Chaperone ATPase Domain from Benchtop and High Field 19F NMR Spectroscopy.

L. Spyracopoulos, Brian L. Lee, Benjamin G. Wajda, 2020, The journal of physical chemistry. B.

Side-Chain Dynamics of the Trifluoroacetone Cysteine Derivative Characterized by 19F NMR Relaxation and Molecular Dynamics Simulations.

L. Spyracopoulos, Brian L. Lee, Benjamin G. Wajda, 2019, The journal of physical chemistry. B.

Probing nascent structures in peptides using natural abundance 13C NMR relaxation and reduced spectral density mapping

B. Sykes, L. Spyracopoulos, C. Slupsky, 2007, Proteins.

A suite of Mathematica notebooks for the analysis of protein main chain 15N NMR relaxation data

L. Spyracopoulos, 2006, Journal of biomolecular NMR.

Backbone dynamics of a bacterially expressed peptide from the receptor binding domain of Pseudomonas aeruginosa pilin strain PAK from heteronuclear 1H-15N NMR spectroscopy

B. Sykes, L. Spyracopoulos, R. Irvin, 2000, Journal of biomolecular NMR.

Backbone and methyl dynamics of the regulatory domain of troponin C: anisotropic rotational diffusion and contribution of conformational entropy to calcium affinity.

L. Kay, B. Sykes, L. Spyracopoulos, 1998, Journal of molecular biology.

Temperature dependence of dynamics and thermodynamics of the regulatory domain of human cardiac troponin C.

B D Sykes, B. Sykes, L. Spyracopoulos, 2001, Biochemistry.

Structure, dynamics, and thermodynamics of the structural domain of troponin C in complex with the regulatory peptide 1-40 of troponin I.

B. Sykes, P. Mercier, L. Spyracopoulos, 2001, Biochemistry.

An NMR-based Model of the Ubiquitin-bound Human Ubiquitin Conjugation Complex Mms2·Ubc13

Michael J. Ellison, Wei Xiao, W. Xiao, 2003, The Journal of Biological Chemistry.

Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting.

J. Glover, L. Spyracopoulos, C. D. Hodge, 2015, ACS chemical biology.

The Mechanism of Hsp90 ATPase Stimulation by Aha1

L. Spyracopoulos, P. LaPointe, Brian L. Lee, 2016, Scientific Reports.

Accuracy and precision of protein–ligand interaction kinetics determined from chemical shift titrations

L. Spyracopoulos, C. Markin, Craig J. Markin, 2012, Journal of Biomolecular NMR.

Accuracy and precision of protein–ligand interaction kinetics determined from chemical shift titrations

L. Spyracopoulos, Craig J Markin, Leo Spyracopoulos, 2012, Journal of biomolecular NMR.

The Hsp90 Chaperone: 1H and 19F Dynamic Nuclear Magnetic Resonance Spectroscopy Reveals a Perfect Enzyme.

L. Spyracopoulos, P. LaPointe, Brian L. Lee, 2019, Biochemistry.

Thermodynamic insights into proteins from NMR spin relaxation studies.

B. Sykes, L. Spyracopoulos, 2001, Current opinion in structural biology.

Active Site Gate Dynamics Modulate the Catalytic Activity of the Ubiquitination Enzyme E2-25K

W. Xiao, M. Rout, L. Spyracopoulos, 2018, Scientific Reports.

Structural Basis for Non-Covalent Interaction Between Ubiquitin and the Ubiquitin Conjugating Enzyme Variant Human MMS2

W. Xiao, D. Hau, L. Spyracopoulos, 2006, Journal of biomolecular NMR.

Context-dependent remodeling of structure in two large protein fragments.

L. Spyracopoulos, A. MacMillan, M. Schellenberg, 2010, Journal of molecular biology.

Structure of the C-domain of Human Cardiac Troponin C in Complex with the Ca2+ Sensitizing Drug EMD 57033*

B. Sykes, L. Spyracopoulos, R. Solaro, 2001, The Journal of Biological Chemistry.

The Proteasome: More Than a Means to an End.

L. Spyracopoulos, 2016, Structure.

Effect of a Hydrophobic Environment on the Hydrogen Exchange Kinetics of Model Amides Determined by 1H-NMR Spectroscopy

L. Spyracopoulos, J. O'Neil, 1994 .

Mechanism for recognition of polyubiquitin chains: balancing affinity through interplay between multivalent binding and dynamics.

W. Xiao, L. Spyracopoulos, C. Markin, 2010, Journal of the American Chemical Society.

Low-temperature-induced structural changes in the Apo regulatory domain of skeletal muscle troponin C.

B. Sykes, L. Spyracopoulos, S. Tsuda, 1999, Biochemistry.

Molecular Basis for Impaired DNA Damage Response Function Associated with the RAP80 ΔE81 Defect*

Anamika, M. Rout, L. Spyracopoulos, 2014, The Journal of Biological Chemistry.

Stochastic gate dynamics regulate the catalytic activity of ubiquitination enzymes.

W. Xiao, J. Glover, M. Rout, 2014, Journal of the American Chemical Society.

Increased precision for analysis of protein–ligand dissociation constants determined from chemical shift titrations

L. Spyracopoulos, C. Markin, 2012, Journal of biomolecular NMR.

Main chain and side chain dynamics of the ubiquitin conjugating enzyme variant human Mms2 in the free and ubiquitin-bound States.

L. Spyracopoulos, M. Lewis, L. F. Saltibus, 2005, Biochemistry.

RYBP Is a K63-Ubiquitin-Chain-Binding Protein that Inhibits Homologous Recombination Repair.

L. Spyracopoulos, M. Hendzel, H. Strickfaden, 2018, Cell reports.

Context-dependent remodeling of structure in two large protein fragments.

L. Spyracopoulos, A. MacMillan, M. Schellenberg, 2010, Journal of molecular biology.

THE EVALUATION OF ISOTOPE EDITING AND FILTERING FOR PROTEIN-LIGAND INTERACTION ELUCIDATION BY NMR

I. M. Robertson, B. Sykes, L. Spyracopoulos, 2009 .

Letter to the Editor: Complete 1H, 13C and 15N backbone assignments for the hepatitis A virus 3C protease

D. Wishart, B. Sykes, L. Spyracopoulos, 2001, Journal of biomolecular NMR.

A mutation in the catalytic loop of Hsp90 specifically impairs ATPase stimulation by Aha1p, but not Hch1p.

L. Spyracopoulos, P. LaPointe, J. Knowles, 2014, Journal of molecular biology.

Structural basis of prion inhibition by phenothiazine compounds.

A. Aguzzi, M. James, P. K. Baral, 2014, Structure.

Dynamics and thermodynamics of the regulatory domain of human cardiac troponin C in the apo- and calcium-saturated states.

B D Sykes, B. Sykes, L. Spyracopoulos, 1998, Biochemistry.