J. Wilsbacher

发表

Vav GEFs are required for β2 integrin-dependent functions of neutrophils

T. Mayadas, K. Ley, M. A. M. Gakidis, 2004, The Journal of cell biology.

Phosphorylation of MAP Kinases by MAP/ERK Involves Multiple Regions of MAP Kinases*

E. Goldsmith, J. Wilsbacher, M. Cobb, 1999, The Journal of Biological Chemistry.

WNK1, a Novel Mammalian Serine/Threonine Protein Kinase Lacking the Catalytic Lysine in Subdomain II*

E. Goldsmith, J. Wilsbacher, M. Cobb, 2000, The Journal of Biological Chemistry.

ERK Nuclear Translocation Is Dimerization-independent but Controlled by the Rate of Phosphorylation*♦

J. Post, J. Wilsbacher, B. Rieger, 2009, The Journal of Biological Chemistry.

ERK2 enters the nucleus by a carrier-independent mechanism

K. Luby-Phelps, J. Wilsbacher, M. Cobb, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of mitogen-activated protein kinase (MAPK) dimers.

E. Goldsmith, J. Wilsbacher, M. Cobb, 2006, Biochemistry.

Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors

Yan Shi, S. C. Panchal, Eric F. Johnson, 2015, Molecular Cancer Research.

Bacterial expression of activated mitogen-activated protein kinases.

J. Wilsbacher, M. Cobb, 2001, Methods in enzymology.

New insights into the control of MAP kinase pathways.

J. Swantek, J. Wilsbacher, M. Cobb, 1999, Experimental Cell Research.

PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow

S. C. Panchal, Mikkel A. Algire, P. Ellis, 2018, Molecular Cancer Research.

Activation of Syk protein tyrosine kinase through interaction with integrin β cytoplasmic domains

J. Wilsbacher, J. Brugge, M. Ginsberg, 2001, Current Biology.

Extracellular Signal-Regulated Kinase Activates Topoisomerase IIα through a Mechanism Independent of Phosphorylation

N. Osheroff, N. Ahn, J. Wilsbacher, 1999, Molecular and Cellular Biology.

Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors

C. Tse, K. Longenecker, P. Richardson, 2017, Molecular Cancer Therapeutics.

SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).

Ana L. Aguirre, Mikkel A. Algire, C. Tse, 2017, Bioorganic & medicinal chemistry letters.

Utilization of 18F-Fluorodeoxyglucose–Positron Emission Tomography To Understand the Mechanism of Nicotinamide Phosphoribosyltransferase Inhibitors In Vivo

C. Tse, J. Wilsbacher, Dong Cheng, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Utilization of 18 F-Fluorodeoxyglucose – Positron Emission Tomography To Understand the Mechanism of Nicotinamide Phosphoribosyltransferase Inhibitors In Vivo s

C. Tse, J. Wilsbacher, Dong Cheng, 2019 .

Accumulation of labeled cyanide in neuronal tissue.

J. Wilsbacher, J. Borowitz, A. Kanthasamy, 1994, Toxicology and applied pharmacology.

Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases.

S. Davidsen, Eric F. Johnson, J. Wilsbacher, 2010, Bioorganic & medicinal chemistry letters.

Pyrazolo[3,4-d]pyrimidines as potent inhibitors of the insulin-like growth factor receptor (IGF-IR).

S. Davidsen, Eric F. Johnson, J. Wilsbacher, 2007, Bioorganic & medicinal chemistry letters.

Advances towards the Development of ATP‐Competitive Small‐Molecule Inhibitors of the Insulin‐Like Growth Factor Receptor (IGF‐IR)

J. Wilsbacher, R. Hubbard, 2007, ChemMedChem.

Phosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear Translocation

E. Goldsmith, J. Wilsbacher, B. Canagarajah, 1998, Cell.

Calcium-sensing receptor and renal cation handling

E. Goldsmith, J. Wilsbacher, S. Stippec, 2003 .

Akt inhibitor a-443654 interferes with mitotic progression by regulating aurora a kinase expression.

X. Liu, J. Wilsbacher, V. Giranda, 2008, Neoplasia.

Substrate Recognition Domains within Extracellular Signal-regulated Kinase Mediate Binding and Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase-3*

A. Brunet, J. Wilsbacher, M. Camps, 2000, The Journal of Biological Chemistry.

Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis.

M. Glogauer, M. A. M. Gakidis, J. Wilsbacher, 2006, Immunity.

An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand

J. Wilsbacher, S. Moores, J. Brugge, 2006, Cell Communication and Signaling.

Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.

Scott A. Erickson, S. Davidsen, K. Swinger, 2010, Bioorganic & medicinal chemistry letters.

Phosphorylation of the MAP Kinase ERK 2 Promotes Its Homodimerization and Nuclear Translocation complex factors and helix-loop-helix proteins

E. Goldsmith, J. Wilsbacher, B. Canagarajah, 1998 .

Controlling cellular distribution of drugs with permeability modifying moieties.

P. Richardson, A. Vasudevan, J. Wilsbacher, 2019, MedChemComm.

Mechanistic Dissection of PARP 1 Trapping and the Impacton InVivo TolerabilityandEf fi cacyofPARP Inhibitors

Eric F. Johnson, J. Wilsbacher, E. DiGiammarino, 2015 .

Identification of novel resistance mechanisms to NAMPT inhibition via the de novo NAD+ biosynthesis pathway and NAMPT mutation.

K. Glaser, L. Lam, C. Tse, 2017, Biochemical and biophysical research communications.

Transcriptomics reveals in vivo efficacy of PARP inhibitor combinatorial synergy with platinum-based chemotherapy in human non-small cell lung carcinoma models

P. Ellis, J. Wilsbacher, T. Pakozdi, 2021, Oncotarget.

Insulin-like Growth Factor-1 Receptor and ErbB Kinase Inhibitor Combinations Block Proliferation and Induce Apoptosis through Cyclin D1 Reduction and Bax Activation*

S. Davidsen, J. Wilsbacher, Gary T. Wang, 2008, Journal of Biological Chemistry.

The N-terminal ERK-binding Site of MEK1 Is Required for Efficient Feedback Phosphorylation by ERK2 in Vitro and ERK Activation in Vivo *

J. Wilsbacher, M. Cobb, Bing-e Xu, 1999, The Journal of Biological Chemistry.

Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases.

Scott A. Erickson, S. Davidsen, Eric F. Johnson, 2009, Bioorganic & medicinal chemistry letters.

Extracellular Signal-Regulated Kinase Activates Topoisomerase IIα through a Mechanism Independent of Phosphorylation

N. Osheroff, N. Ahn, J. Wilsbacher, 1999, Molecular and Cellular Biology.

Phosphorylation Mechanism Independent of through a Α Activates Topoisomerase Ii Extracellular Signal-regulated Kinase

N. Osheroff, N. Ahn, J. Wilsbacher, 1999 .