R. Hughes

发表

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR.

M. Bowman, J. Noel, J. Hogenesch, 2003, Molecular cell.

New Selenium-Based Safety-Catch Linkers: Solid-Phase Semisynthesis of Vancomycin

R. Hughes, K. Nicolaou, N. Winssinger, 2000 .

Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy

Amy L. Lane, James L. Miller, D. Radisky, 2017, Oncotarget.

Discovery and Optimization of Non‐steroidal FXR Agonists from Natural Product‐Like Libraries.

R. Evans, M. Downes, R. Hughes, 2003 .

Modifications of the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide.

V. Hruby, R. Hughes, B. Lou, 1998, Bioorganic & Medicinal Chemistry Letters.

Combinatorial synthesis through disulfide exchange: discovery of potent psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA).

A. Roecker, R. Hughes, K. Nicolaou, 2001, Chemistry.

Solid- and solution-phase synthesis of vancomycin and vancomycin analogues with activity against vancomycin-resistant bacteria.

R. Hughes, K. Nicolaou, N. Winssinger, 2001, Chemistry.

Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidase.

C. Bewley, R. Hughes, K. Nicolaou, 2002, Bioorganic & medicinal chemistry letters.

Novel strategies for the solid phase synthesis of substituted indolines and indoles.

R. Hughes, K. Nicolaou, J. Pfefferkorn, 2003, Bioorganic & medicinal chemistry.

Total Synthesis of Vancomycin—Part 2: Retrosynthetic Analysis, Synthesis of Amino Acid Building Blocks and Strategy Evaluations

Stefan Bräse, Robert Hughes, Hui Li, 1999 .

Synthesis and biological evaluation of vancomycin dimers with potent activity against vancomycin-resistant bacteria: target-accelerated combinatorial synthesis.

R. Hughes, K. Nicolaou, N. Winssinger, 2001, Chemistry.

Target-Accelerated Combinatorial Synthesis and Discovery of Highly Potent Antibiotics Effective Against Vancomycin-Resistant Bacteria.

Robert Hughes, Nicolas Winssinger, K C Nicolaou, 2000, Angewandte Chemie.

Generation of C-Glycoside Peptide Ligands for Cell Surface Carbohydrate Receptors Using a Four-Component Condensation on Solid Support.

R. Hughes, D. Sutherlin, R. W. Armstrong, 1996, The Journal of organic chemistry.

Total Synthesis of Vancomycin—Part 4: Attachment of the Sugar Moieties and Completion of the Synthesis

R. Hughes, K. Nicolaou, N. Winssinger, 1999 .

Total Synthesis of Vancomycin Aglycon-Part 2: Synthesis of Amino Acids 1-3 and Construction of the AB-COD-DOE Ring Skeleton.

R. Hughes, K. Nicolaou, T. Bando, 1998, Angewandte Chemie.

TOTAL SYNTHESIS OF VANCOMYCIN. PART 3 : SYNTHESIS OF THE AGLYCON

R. Hughes, K. Nicolaou, T. Bando, 1999 .

Total Synthesis of Vancomycin

R. Hughes, K. Nicolaou, N. Winssinger, 1999 .

Combinatorial synthesis through disulfide exchange: discovery of potent psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA).

K C Nicolaou, A. Roecker, R. Hughes, 2001, Chemistry.

Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries.

R. Evans, M. Downes, R. Hughes, 2003, Organic & biomolecular chemistry.

Optimization and mechanistic studies of psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA).

R. Hughes, K. Nicolaou, J. Pfefferkorn, 2001, Chemistry.

Total Synthesis of Vancomycin

R. Hughes, K. Nicolaou, N. Winssinger, 1999 .

Total Synthesis of Vancomycin Aglycon-Part 2: Synthesis of Amino Acids 1-3 and Construction of the AB-COD-DOE Ring Skeleton.

R. Hughes, K. Nicolaou, T. Bando, 1998, Angewandte Chemie.