P. Edwards

发表

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR.

M. Bowman, J. Noel, J. Hogenesch, 2003, Molecular cell.

Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics.

P. Edwards, A. Lusis, L. Demer, 1995, Circulation.

Localization of 3-hydroxy-3-methylglutaryl CoA reductase and 3-hydroxy-3-methylglutaryl CoA synthase in the rat liver and intestine is affected by cholestyramine and mevinolin.

P. Edwards, A. Fogelman, A. Li, 1988, Journal of lipid research.

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice.

Timothy M Willson, Yanqiao Zhang, T. Willson, 2006, Proceedings of the National Academy of Sciences of the United States of America.

The effect of cholestyramine and Mevinolin on the diurnal cycle of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase.

P. Edwards, A. Fogelman, R. Tanaka, 1982, Journal of lipid research.

Rabbit beta-migrating very low density lipoprotein increases endothelial macromolecular transport without altering electrical resistance.

P. Edwards, J. Berliner, M. Navab, 1986, The Journal of clinical investigation.

ATP-binding cassette transporter G1 and lipid homeostasis

Paul T. Tarr, Richard G. Lee, P. Edwards, 2006, Current opinion in lipidology.

Human White/Murine ABC8 mRNA Levels Are Highly Induced in Lipid-loaded Macrophages

D. Mangelsdorf, P. Edwards, J. Repa, 2000, The Journal of Biological Chemistry.

Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway.

P. Edwards, J. Ericsson, 1999, Annual review of biochemistry.

Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages.

P. Edwards, J. Child, I. Shechter, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Regulated Expression of the Apolipoprotein E/C-I/C-IV/C-II Gene Cluster in Murine and Human Macrophages

D. Mangelsdorf, P. Edwards, S. Joseph, 2002, The Journal of Biological Chemistry.

CBP Is Required for Sterol-regulated and Sterol Regulatory Element-binding Protein-regulated Transcription*

P. Edwards, J. Ericsson, Johan Ericsson, 1998, The Journal of Biological Chemistry.

Pathogenesis of Atherosclerosis

A. J. Lusis, P. Edwards, A. Lusis, 1964, The American journal of cardiology.

Molecular cloning and promoter analysis of the rat liver farnesyl diphosphate synthase gene.

P. Edwards, C. C. Correll, D. Spear, 1992, The Journal of biological chemistry.

Molecular Cloning and Sequence of a Cholesterol-Repressible Enzyme Related to Prenyltransferase in the Isoprene Biosynthetic Pathway

K. Svenson, P. Edwards, C. Clarke, 1987, Molecular and cellular biology.

Molecular cloning and sequence of a cholesterol-repressible enzyme related to prenyltransferase in the isoprene biosynthetic pathway

P. Edwards, C. Clarke, A. Fogelman, 1987 .

Impaired Development of Atherosclerosis in Hyperlipidemic Ldlr−/− and ApoE−/− Mice Transplanted With Abcg1−/− Bone Marrow

Andrew C. Li, Paul T. Tarr, Richard G. Lee, 2006, Arteriosclerosis, thrombosis, and vascular biology.

MicroRNA-144 Regulates Hepatic ATP Binding Cassette Transporter A1 and Plasma High-Density Lipoprotein After Activation of the Nuclear Receptor Farnesoid X Receptor

P. Edwards, M. Civelek, Á. Baldán, 2013, Circulation research.

A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids Published, JLR Papers in Press, November 3, 2005.

Heidi R. Kast-Woelbern, P. Edwards, D. Shih, 2006, Journal of Lipid Research.

Hepatic Hepatocyte Nuclear Factor 4&agr; Is Essential for Maintaining Triglyceride and Cholesterol Homeostasis

P. Edwards, Yanqiao Zhang, Huiyan Ma, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Signaling molecules derived from the cholesterol biosynthetic pathway.

P. Edwards, S. Jackson, J. Ericsson, 1997, Sub-cellular biochemistry.

A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis.

R. Evans, P. Edwards, A. Chawla, 2001, Molecular cell.

α-Crystallin Is a Target Gene of the Farnesoid X-activated Receptor in Human Livers*

M. Fishbein, Heidi R. Kast-Woelbern, P. Edwards, 2005, Journal of Biological Chemistry.

LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition.

P. Edwards, D. Ford, P. Tontonoz, 2013, Cell metabolism.

FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption.

Julia J. Mack, P. Meikle, P. Edwards, 2021, Cell metabolism.

Specificity of receptor-mediated recognition of malondialdehyde-modified low density lipoproteins.

P. Edwards, A. Fogelman, M. Haberland, 1982, Proceedings of the National Academy of Sciences of the United States of America.

A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

R. Evans, P. Edwards, A. Chawla, 2001 .

Regulation of ABCG1 expression in human keratinocytes and murine epidermis[S]

P. Edwards, P. Elias, K. Feingold, 2006, Journal of Lipid Research.

Assignment of human 3-hydroxy-3-methylglutaryl coenzyme A reductase gene to q13 → q23 region of chromosome 5

T. Mohandas, P. Edwards, A. Lusis, 1986, Somatic cell and molecular genetics.

Mechanisms controlling competence gene expression in murine fibroblasts stimulated with minimally modified LDL.

K. Svenson, P. Edwards, A. Lusis, 1992, Arteriosclerosis and thrombosis : a journal of vascular biology.

Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR

P. Edwards, L. Castellani, F. Gonzalez, 2004 .

The effect of glucagon, norepinephrine, and dibutyryl cyclic AMP on cholesterol efflux and on the activity of 3-hydroxy-3-methylglutaryl CoA reductase in rat hepatocytes.

P. Edwards, A. Fogelman, D. Lemongello, 1979, Journal of lipid research.

Inhibition of lysosomal protein degradation inhibits the basal degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

P. Edwards, A. Fogelman, A. Li, 1986, Journal of lipid research.

Identification of Glycerol-3-phosphate Acyltransferase as an Adipocyte Determination and Differentiation Factor 1- and Sterol Regulatory Element-binding Protein-responsive Gene*

B. Spiegelman, P. Edwards, S. Jackson, 1997, The Journal of Biological Chemistry.

The metabolism of native and malondialdehyde-altered low density lipoproteins by human monocyte-macrophages.

P. Edwards, I. Shechter, A. Fogelman, 1981, Journal of lipid research.

Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors Published, JLR Papers in Press, October 16, 2002. DOI 10.1194/jlr.C200014-JLR200

Heidi R. Kast-Woelbern, A. Anisfeld, P. Edwards, 2002, Journal of Lipid Research.

NF-Y Has a Novel Role in Sterol-dependent Transcription of Two Cholesterogenic Genes (*)

P. Edwards, T. Osborne, S. Jackson, 1995, The Journal of Biological Chemistry.

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha.

P. Edwards, S. Joseph, P. Tontonoz, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Activation of the Farnesoid X-Activated Receptor Provides Protection against Acetaminophen-Induced Hepatic Toxicity

P. Edwards, T. Osborne, Yanqiao Zhang, 2010 .

Role for sterol regulatory element binding protein in the regulation of farnesyl diphosphate synthase and in the control of cellular levels of cholesterol and triglyceride: evidence from sterol regulation-defective cells.

P. Edwards, S. Jackson, J. Ericsson, 1996, Journal of lipid research.

Bile acids have the gall to function as hormones.

P. Edwards, T. Vallim, 2009, Cell metabolism.

Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells.

P. Edwards, M. Rogers, J. Crockett, 2014, Biochimica et biophysica acta.

Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester.

P. Edwards, D. Wilkin, S. Y. Kutsunai, 1990, The Journal of biological chemistry.

ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2 Published, JLR Papers in Press, October 4, 2007.

Paul T. Tarr, P. Edwards, P. Tarr, 2008, Journal of Lipid Research.

Chapter 8 Cellular regulation of cholesterol metabolism

P. Edwards, C. Clarke, A. Fogelman, 1987 .

Macrophage lipoprotein receptors

P. Edwards, A. Fogelman, M. Haberland, 1988, Journal of Cell Science.

LDL, scavenger, and beta-VLDL receptors on aortic endothelial cells.

P. Edwards, D. Baker, J. Berliner, 1984, Arteriosclerosis.

Factors regulating the activities of the low density lipoprotein receptor and the scavenger receptor on human monocyte-macrophages.

P. Edwards, A. Fogelman, M. Haberland, 1981, Journal of lipid research.

Some New Aspects of the Regulation of Cholesterol Biosynthesis and Metabolism of Mevalonate

P. Edwards, A. Fogelman, J. Edmond, 1976 .

Chapter 13 Regulation of sterol biosynthesis and isoprenylation of proteins

P. Edwards, 1991 .

Molecular cloning and sequence of a cholesterol-repressible enzyme related to prenyltransferase in the isoprene biosynthetic pathway

P. Edwards, C. Clarke, A. Fogelman, 1987 .

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in avian myeloblasts. Mode of action of 25-hydroxycholesterol.

P. Edwards, A. Fogelman, R. Tanaka, 1983, Journal of Biological Chemistry.

Mevalonolactone inhibits the rate of synthesis and enhances the rate of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat hepatocytes.

P. Edwards, A. Fogelman, R. Tanaka, 1983, The Journal of biological chemistry.

Chapter 13 – Isoprenoids, sterols and bile acids

Roger A. Davis, P. Edwards, R. A. Davis, 1996 .

Fatty livers and reduced adipose tissue, who wants it?

P. Edwards, 1996, The Journal of clinical investigation.

Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

P. Edwards, C. C. Correll, L. Ng, 1994, The Journal of biological chemistry.

Macrophage lipoprotein metabolism in atherosclerosis

P. Edwards, M. Navab, A. Fogelman, 1985 .

Diurnal rhythm of rat liver mRNAs encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase. Correlation of functional and total mRNA levels with enzyme activity and protein.

P. Edwards, C. Clarke, A. Fogelman, 1984, The Journal of biological chemistry.

Alterations in the rates of synthesis and degradation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase produced by cholestyramine and mevinolin.

P. Edwards, A. Fogelman, S. Lan, 1983, The Journal of biological chemistry.

The influence of catecholamines and cyclic AMP on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and lipid biosynthesis in isolated rat hepatocytes.

P. Edwards, 1975, Archives of biochemistry and biophysics.

The role of lipoproteins and receptor-mediated endocytosis in the transport of bacterial lipopolysaccharide.

P. Edwards, A. Fogelman, M. Haberland, 1986, Proceedings of the National Academy of Sciences of the United States of America.

The ABCs of sterol transport 1

P. Edwards, Á. Baldán, D. Bojanic, 2009 .

Receptor-mediated uptake of remnant lipoproteins by cholesterol-loaded human monocyte-macrophages.

P. Edwards, A. Fogelman, M. Haberland, 1985, The Journal of biological chemistry.

Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR.

P. Edwards, L. Castellani, F. Gonzalez, 2004, Genes & development.

Transcriptional regulation of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in rat liver.

P. Edwards, C. Clarke, A. Fogelman, 1985, The Journal of biological chemistry.

Properties of purified rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and regulation of enzyme activity.

P. Edwards, I. Shechter, A. Fogelman, 1980, The Journal of biological chemistry.

Improved methods for the solubilization and assay of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase.

P. Edwards, A. Fogelman, D. Lemongello, 1979, Journal of lipid research.

Deletion of the Transmembrane Transporter ABCG1 Results in Progressive Pulmonary Lipidosis*

Paul T. Tarr, P. Edwards, Á. Baldán, 2006, Journal of Biological Chemistry.

Notes on the breeding of the WHHL rabbit: an animal model of familial hypercholesterolemia.

P. Edwards, A. Fogelman, C. Kean, 1985, Journal of lipid research.

Control of 3-hydroxy-3-methylglutaryl coenzyme A reductase by endogenously synthesized sterols in vitro and in vivo.

P. Edwards, A. Fogelman, J. Edmond, 1977, The Journal of biological chemistry.

The effect of glucagon on the synthesis and degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

P. Edwards, A. Fogelman, S. Lan, 1988, Journal of lipid research.

Effect of plasma lipoproteins and lecithin-cholesterol dispersions on the activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase of isolated rat hepatocytes.

P. Edwards, 1975, Biochimica et biophysica acta.

4 – Studies on Purified Mammalian HMG-CoA Reductase and Regulation of Enzyme Activity

P. Edwards, 1985 .

Testis-specific transcription initiation sites of rat farnesyl pyrophosphate synthetase mRNA

P. Edwards, C. Clarke, D. Spear, 1990, Molecular and cellular biology.

A direct relationship between the amount of sterol lost from rat hepatocytes and the increase in activity of HMG-CoA reductase.

P. Edwards, A. Fogelman, G. Popják, 1976, Biochemical and biophysical research communications.

Loss of ABCG1 Results in Chronic Pulmonary Inflammation1

P. Ping, P. Edwards, A. Gomes, 2008, The Journal of Immunology.

Separation of and cholesterol synthesis by human lymphocytes and monocytes.

P. Edwards, A. Fogelman, J. Seager, 1979, Journal of lipid research.

In vivo demonstration of the circadian thythm of cholesterol biosynthesis in the liver and intestine of the rat.

P. Edwards, R. Gould, H. Muroya, 1972, Journal of lipid research.

Radioimmune precipitation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from Chinese hamster fibroblasts. Effect of 25-hydroxycholesterol.

P. Edwards, R. Torget, M. Sinensky, 1981, The Journal of biological chemistry.

Identification of a 6-base pair element involved in the sterol-mediated transcriptional regulation of farnesyl diphosphate synthase.

P. Edwards, J. Ericsson, S. M. Jackson, 1994, The Journal of biological chemistry.

Effect of site-directed mutagenesis of conserved aspartate and arginine residues upon farnesyl diphosphate synthase activity.

P. Edwards, A. Joly, 1993, The Journal of biological chemistry.

In vitro identification of a soluble protein:geranylgeranyl transferase from rat tissues.

P. Edwards, A. Joly, G. Popják, 1991, The Journal of biological chemistry.

Lymphocyte-conditioned medium protects human monocyte-macrophages from cholesteryl ester accumulation.

P. Edwards, A. Fogelman, R. Tanaka, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Developmental changes in the expression of genes involved in cholesterol biosynthesis and lipid transport in human and rat fetal and neonatal livers.

J. Gordon, P. Edwards, A. Schwartz, 1989, Biochimica et biophysica acta.

Purification and properties of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase.

P. Edwards, A. Fogelman, D. Lemongello, 1979, Biochimica et biophysica acta.

The regulation of acetoacetyl-CoA synthetase activity by modulators of cholesterol synthesis in vivo and the utilization of acetoacetate for cholesterogenesis.

P. Edwards, J. Edmond, J. Bergstrom, 1984, The Journal of biological chemistry.

Differential expression and function of ABCG1 and ABCG4 during development and aging.

Greg D. Gale, Paul T. Tarr, Desmond J. Smith, 2010, Journal of lipid research.

Cholesterol biosynthesis in human lymphocytes, monocytes, and granulocytes.

P. Edwards, A. Fogelman, G. Popják, 1977, Biochemical and biophysical research communications.

Impaired Development of Atherosclerosis in Abcg1−/− Apoe−/− Mice: Identification of Specific Oxysterols That Both Accumulate in Abcg1−/− Apoe−/− Tissues and Induce Apoptosis

P. Edwards, A. Lusis, D. Bojanic, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Purification of 3-hydroxy-3-methylglutaryl coenzyme A reductase from human liver.

P. Edwards, A. Fogelman, R. Tanaka, 1982, Journal of lipid research.

Pleiotropic roles of bile acids in metabolism.

P. Edwards, E. Tarling, T. Q. de Aguiar Vallim, 2013, Cell metabolism.

Platelet Production of Pathological LDL

P. Edwards, J. Child, I. Shechter, 1980 .

Mechanism of induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human leukocytes.

P. Edwards, A. Fogelman, G. Popják, 1977, The Journal of biological chemistry.

Preferential uptake and utilization of mevalonolactone over mevalonate for sterol biosynthesis in isolated rat hepatocytes.

P. Edwards, A. Fogelman, J. Edmond, 1977, Biochimica et biophysica acta.

Dependence of the circadian rhythm of hepatic beta-hydroxy-beta-methylglutaryl coenzyme A on ribonucleic acid synthesis. A possible second site of inhibition by dietary cholesterol.

P. Edwards, R. Gould, 1974, The Journal of biological chemistry.

Effect of adrenalectomy and hypophysectomy on the circadian rhythm of -hydroxy- -methylglutaryl coenzyme A reductase activity in rat liver.

P. Edwards, 1973, The Journal of biological chemistry.

Turnover rate of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase as determined by use of cycloheximide.

P. Edwards, R. Gould, 1972, The Journal of biological chemistry.

Identification of Conserved cis-Elements and Transcription Factors Required for Sterol-regulated Transcription of Stearoyl-CoA Desaturase 1 and 2*

B. Spiegelman, D. Tabor, P. Edwards, 1999, The Journal of Biological Chemistry.

BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis.

A. Anisfeld, P. Edwards, H. R. Kast, 2002, Journal of lipid research.

Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling Published, JLR Papers in Press, December 16, 2004. DOI 10.1194/jlr.M400292-JLR200

Heidi R. Kast-Woelbern, A. Anisfeld, P. Edwards, 2005, Journal of Lipid Research.

Effects of site-directed mutagenesis of the highly conserved aspartate residues in domain II of farnesyl diphosphate synthase activity.

P. Edwards, C. Poulter, P. Marrero, 1992, The Journal of biological chemistry.

Determination of mevalonate in blood plasma in man and rat. Mevalonate "tolerance" tests in man.

P. Edwards, A. Fogelman, J. Edmond, 1979, Journal of lipid research.

Analysis of regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in a somatic cell mutant auxotrophic for mevalonate.

P. Edwards, R. Torget, M. Sinensky, 1982, The Journal of biological chemistry.

Testis-specific transcripts of rat farnesyl pyrophosphate synthetase are developmentally regulated and localized to haploid germ cells.

E. Salido, P. Edwards, C. Clarke, 1991, Biology of reproduction.

Developmentally Regulated and Localized to Haploid Germ Cells1

E. Salido, P. Edwards, C. Clarke, 1991 .

LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response

Peter Tontonoz, Peter A. Edwards, P. Edwards, 2008, Cell.

Functional size of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase as determined by radiation inactivation.

P. Edwards, E. Kempner, S. Lan, 1985, The Journal of biological chemistry.

Role of ABC transporters in lipid transport and human disease

Peter A. Edwards, P. Edwards, E. Tarling, 2013, Trends in Endocrinology & Metabolism.

ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation.

Paul T. Tarr, M. Fishbein, P. Edwards, 2005, Cell metabolism.

Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene.

P. Edwards, S. Jackson, J. Ericsson, 1996, Proceedings of the National Academy of Sciences of the United States of America.

COQ2 is a candidate for the structural gene encoding para-hydroxybenzoate:polyprenyltransferase.

P. Edwards, S. Ackerman, A. Tzagoloff, 1992, The Journal of biological chemistry.

Regulation of gene expression by SREBP and SCAP.

D Tabor, D. Tabor, P. Edwards, 2000, Biochimica et biophysica acta.

Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression.

D. Duan, P. Edwards, J. Ericsson, 1998, Journal of lipid research.

Identification and regulation of a rat liver cDNA encoding farnesyl pyrophosphate synthetase.

P. Edwards, M. Ashby, 1989, The Journal of biological chemistry.

Elucidation of the deficiency in two yeast coenzyme Q mutants. Characterization of the structural gene encoding hexaprenyl pyrophosphate synthetase.

P. Edwards, M. Ashby, M N Ashby, 1990, The Journal of biological chemistry.

A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism

Richard G. Lee, C. Dieterich, I. Ulitsky, 2020, Nature Communications.

FXR signaling in metabolic disease

P. Edwards, Yanqiao Zhang, 2008, FEBS letters.

Characterization of the Human ABCG1 Gene

Paul T. Tarr, I. Xenarios, N. Shimizu, 2001, The Journal of Biological Chemistry.

Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration.

I. Chowers, P. Edwards, J. Harbour, 2013, Cell metabolism.

CTP:phosphocholine cytidylyltransferase, a new sterol- and SREBP-responsive gene.

A. Anisfeld, P. Edwards, J. Ericsson, 2001, Journal of lipid research.

Synergistic Binding of Sterol Regulatory Element-binding Protein and NF-Y to the Farnesyl Diphosphate Synthase Promoter Is Critical for Sterol-regulated Expression of the Gene*

P. Edwards, S. Jackson, J. Ericsson, 1996, The Journal of Biological Chemistry.

MAFG is a transcriptional repressor of bile acid synthesis and metabolism.

Richard G. Lee, P. Edwards, Masayuki Yamamoto, 2015, Cell metabolism.

Emerging new paradigms for ABCG transporters.

Paul T Tarr, Paul T. Tarr, P. Edwards, 2009, Biochimica et biophysica acta.

FXR, a multipurpose nuclear receptor.

Yanqiao Zhang, P. Edwards, Hans Lee, 2006, Trends in biochemical sciences.

Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.

Brian J. Bennett, Richard G. Lee, S. Hazen, 2013, Cell metabolism.

Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity.

Yanqiao Zhang, P. Edwards, T. Osborne, 2010, Molecular endocrinology.

Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor*

Paul T Tarr, Peter Tontonoz, Timothy M Willson, 2002, The Journal of Biological Chemistry.

YY1 Is a Negative Regulator of Transcription of Three Sterol Regulatory Element-binding Protein-responsive Genes*

P. Edwards, A. Usheva, J. Ericsson, 1999, The Journal of Biological Chemistry.

Transcriptional Activation of the Stearoyl-CoA Desaturase 2 Gene by Sterol Regulatory Element-binding Protein/Adipocyte Determination and Differentiation Factor 1*

B. Spiegelman, D. Tabor, P. Edwards, 1998, The Journal of Biological Chemistry.

Synergistic activation of transcription by nuclear factor Y and sterol regulatory element binding protein.

P. Edwards, R. Mantovani, S. Jackson, 1998, Journal of lipid research.

Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1

Xiaohui Xie, P. Edwards, T. Osborne, 2010, Nucleic acids research.

Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice.

Yanqiao Zhang, P. Edwards, C. Novak, 2012, Molecular endocrinology.

Identification of Novel Pathways That Control Farnesoid X Receptor-mediated Hypocholesterolemia*

T. Willson, P. Edwards, F. Gonzalez, 2009, The Journal of Biological Chemistry.

Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism

M. Mann, J. Björkegren, H. Schunkert, 2021, Circulation.

FXR regulates organic solute transporters α and β in the adrenal gland, kidney, and intestine Published, JLR Papers in Press, October 26, 2005.

S. Nelson, P. Edwards, F. Gonzalez, 2006, Journal of Lipid Research.

A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development.

A. Bookout, D. Mangelsdorf, P. Edwards, 2005, Cell metabolism.

The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture.

P. Edwards, D. Shih, A. Lusis, 1996, Arteriosclerosis, thrombosis, and vascular biology.

Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression.

B. Taylor, P. Edwards, A. Lusis, 1992, Journal of lipid research.

Farnesyl-diphosphate synthase is localized in peroxisomes.

P. Edwards, J. Ericsson, S. Krisans, 1994, The Journal of biological chemistry.

Dispersed family of human genes with sequence similarity to farnesyl pyrophosphate synthetase.

T. Mohandas, P. Edwards, C. Clarke, 1989, Genomics.

Dancing with the sterols: critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis.

P. Edwards, E. Tarling, 2012, Biochimica et biophysica acta.

Differential expression and function of ABCG1 and ABCG4 during development and aging[S]

Greg D. Gale, Paul T. Tarr, Desmond J. Smith, 2010, Journal of Lipid Research.

Expression and Regulation of Multiple Murine ATP-binding Cassette Transporter G1 mRNAs/Isoforms That Stimulate Cellular Cholesterol Efflux to High Density Lipoprotein*

P. Edwards, K. Lyons, Á. Baldán, 2004, Journal of Biological Chemistry.

Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550—Brief Report

P. Edwards, E. Tarling, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Abstract 76: MicroRNA-144 Regulates Hepatic ABCA1 and Plasma HDL Following Activation of the Nuclear Receptor FXR

P. Edwards, M. Civelek, Á. Baldán, 2013 .

ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter

P. Edwards, E. Tarling, 2011, Proceedings of the National Academy of Sciences.

Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA levels in rat liver.

P. Edwards, C. Clarke, A. Fogelman, 1983, Proceedings of the National Academy of Sciences of the United States of America.

LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis.

P. Edwards, P. A. Mak, M. Kennedy, 2002, Vascular pharmacology.

Natural Structural Variants of the Nuclear Receptor Farnesoid X Receptor Affect Transcriptional Activation*

Heidi R. Kast-Woelbern, P. Edwards, Yanqiao Zhang, 2003, The Journal of Biological Chemistry.

Identification of the DNA Binding Specificity and Potential Target Genes for the Farnesoid X-activated Receptor*

P. Edwards, D. Moore, B. Laffitte, 2000, The Journal of Biological Chemistry.

FXR Deficiency Causes Reduced Atherosclerosis in Ldlr−/− Mice

P. Edwards, A. Lusis, Hans Lee, 2006, Arteriosclerosis, thrombosis, and vascular biology.

Regulation of hepatic Insig-2 by the farnesoid X receptor.

P. Edwards, Yanqiao Zhang, F. Lee, 2007, Molecular endocrinology.

Mevalonic acid-dependent degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo and in vitro.

P. Edwards, C. C. Correll, 1994, The Journal of biological chemistry.

Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism

M. Mann, J. Björkegren, H. Schunkert, 2021, Circulation.

Signaling molecules derived from the cholesterol biosynthetic pathway: mechanisms of action and possible roles in human disease.

P. Edwards, J. Ericsson, P A Edwards, 1998, Current opinion in lipidology.

FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine.

S. Nelson, P. Edwards, F. Gonzalez, 2006, Journal of lipid research.

Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids.

T. Willson, P. Edwards, F. Gonzalez, 2001, Molecular endocrinology.

CHAPTER 170 – Cholesterol Signaling

Heidi R. Kast-Woelbern, P. Edwards, M. Kennedy, 2003 .

Lipoprotein regulation of cholesterol metabolism in macrophages derived from human monocytes.

P. Edwards, A. Fogelman, R. Tanaka, 1982, The Journal of biological chemistry.

Lymphokines secreted by an established lymphocyte line modulate receptor-mediated endocytosis in macrophages derived from human monocytes.

P. Edwards, J. Groopman, J. Berliner, 1983, Journal of immunology.

Syndecan-1 Expression Is Regulated in an Isoform-specific Manner by the Farnesoid-X Receptor*

T. Willson, Heidi R. Kast-Woelbern, A. Anisfeld, 2003, Journal of Biological Chemistry.

Regulation of the Sodium/Sulfate Co-transporter by Farnesoid X Receptor α*

P. Edwards, T. Osborne, Hans Lee, 2007, Journal of Biological Chemistry.

Regulation of the uptake and degradation of beta-very low density lipoprotein in human monocyte macrophages.

L. Benson, P. Edwards, A. Fogelman, 1983, The Journal of biological chemistry.

Calcium ionophore treatment impairs the sterol-mediated suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, and farnesyl diphosphate synthetase.

P. Edwards, D. Wilkin, 1992, The Journal of biological chemistry.

Bacterial endotoxin selectively prevents the expression of scavenger-receptor activity on human monocyte-macrophages.

P. Edwards, A. Fogelman, E. Ribi, 1985, Journal of immunology.

Coordinate regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and prenyltransferase synthesis but not degradation in HepG2 cells.

P. Edwards, D. Rosser, M. Ashby, 1989, The Journal of biological chemistry.

ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter

P. Edwards, E. Tarling, 2011, Proceedings of the National Academy of Sciences.

In Memoriam: Roger A. Davis (1945–2008)

P. Edwards, A. Attie, A. Lusis, 2008, Journal of Lipid Research.

Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids.

T. Willson, P. Edwards, F. Gonzalez, 2001, Molecular endocrinology.

Impaired Development of Atherosclerosis in Hyperlipidemic Ldlr−/− and ApoE−/− Mice Transplanted With Abcg1−/− Bone Marrow

Andrew C. Li, Paul T. Tarr, Richard G. Lee, 2006, Arteriosclerosis, thrombosis, and vascular biology.

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice.

T. Willson, P. Edwards, F. Gonzalez, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of the Sodium/Sulfate Co-transporter by Farnesoid X Receptor α*

P. Edwards, T. Osborne, Hans Lee, 2007, Journal of Biological Chemistry.