Roland Martin

M. Mayes, B. Sandmaier, Roland Martin, 2005, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Hsp70 Regulates Immune Response in Experimental Autoimmune Encephalomyelitis

X. Montalban, Roland Martin, H. Eixarch, 2014, PloS one.

Disease Progression After Bone Marrow Transplantation in a Model of Multiple Sclerosis Is Associated With Chronic Microglial and Glial Progenitor Response

M. Mattson, F. Eusebi, Roland Martin, 2007, Journal of neuropathology and experimental neurology.

Identification and optimization of antigens for T cell clones of clinical relevance using positional scanning combinatorial libraries

R. Houghten, C. Pinilla, Roland Martin, 2002 .

Understanding risk of PML through multiple sclerosis

Roland Martin, 2018, The Lancet Neurology.

JC virus granule cell neuronopathy and GCN–IRIS under natalizumab treatment

M. Weller, H. Budka, I. Jelcic, 2013, Annals of neurology.

T Cell Epitope Mapping of JC Polyoma Virus-Encoded Proteome Reveals Reduced T Cell Responses in HLA-DRB1*04:01+ Donors

I. Jelcic, R. Planas, I. Jelcic, 2013, Journal of Virology.

Inhibitors of dipeptidyl peptidase IV/CD26 suppress activation of human MBP-specific CD4+ T cell clones

Roland Martin, B. Hemmer, H. McFarland, 1998, Journal of Neuroimmunology.

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

U. Utz, A. Waisman, D. Mitchell, 1996, Nature.

Epstein-Barr Virus: Environmental Trigger of Multiple Sclerosis?

J. Lünemann, Roland Martin, T. Kamradt, 2007, Journal of Virology.

Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis

M. Sormani, Roland Martin, R. Nicholas, 2017, Nature Reviews Neurology.

Autologous Hematopoietic Stem Cell Transplantation as a Treatment Option for Aggressive Multiple Sclerosis

Roland Martin, R. Saccardi, N. Pfender, 2013, Current Treatment Options in Neurology.

In search of cerebrospinal fluid biomarkers of fatigue in multiple sclerosis: A proteomics study

Christian Panse, M. Weller, B. Roschitzki, 2018, Journal of sleep research.

The Orally Available, Synthetic Ether Lipid Edelfosine Inhibits T Cell Proliferation and Induces a Type I Interferon Response

Roland Martin, Pierre Abramowski, B. Otto, 2014, PloS one.

Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis

X. Montalban, Roland Martin, M. Comabella, 2006, Journal of Neuroimmunology.

The NIMH Multisite HIV Prevention Trial: reducing HIV sexual risk behavior. The National Institute of Mental Health (NIMH) Multisite HIV Prevention Trial Group.

Nancy F. Hansen, A. O'Leary, N. Hansen, 1998, Science.

Peptidic complex mixtures as therapeutic agents in CNS autoimmunity.

Clemencia Pinilla, Claus-Steffen Stuerzebecher, Roland Martin, 2004, Molecular immunology.

Antigen-Specific Therapies in Multiple Sclerosis

M. Sospedra, Roland Martin, 2005, International reviews of immunology.

Copolymer-1-induced inhibition of antigen-specific T cell activation: interference with antigen presentation

Roland Martin, H. McFarland, M. Racke, 1992, Journal of Neuroimmunology.

Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk

H. Ullum, T. Werge, H. Hakonarson, 2020, Cell.

Low frequency and rare coding variation contributes to multiple sclerosis risk

H. Ullum, T. Werge, H. Hakonarson, 2018, bioRxiv.

Gender-Associated Differences of Perforin Polymorphisms in the Susceptibility to Multiple Sclerosis

X. Montalban, A. Navarro, Roland Martin, 2010, The Journal of Immunology.

Identification of a Novel Risk Locus for Multiple Sclerosis at 13q31.3 by a Pooled Genome-Wide Scan of 500,000 Single Nucleotide Polymorphisms

D. Craig, X. Montalban, A. Navarro, 2008, PloS one.

Preferential expansion of autoreactive T lymphocytes from the memory T-cell pool by IL-7

Roland Martin, H. McFarland, B. Bielekova, 1999, Journal of Neuroimmunology.

Detailed Characterization of T Cell Receptor Repertoires in Multiple Sclerosis Brain Lesions

R. Planas, M. Sospedra, Roland Martin, 2018, Front. Immunol..

Signaling networks in MS: A systems-based approach to developing new pharmacological therapies

Ioannis N. Melas, Dimitris E. Messinis, G. Silberberg, 2015, Multiple sclerosis.

Restoring immune tolerance in neuromyelitis optica

J. M. Behne, Terry J. Smith, Jeffrey A. Cohen, 2016, Neurology: Neuroimmunology & Neuroinflammation.

Restoring immune tolerance in neuromyelitis optica

J. M. Behne, Terry J. Smith, Jeffrey A. Cohen, 2016, Neurology: Neuroimmunology & Neuroinflammation.

Nogo receptor is involved in the adhesion of dendritic cells to myelin

Roland Martin, C. Bandtlow, F. Kern, 2011, Journal of Neuroinflammation.

Neutrophils in multiple sclerosis are characterized by a primed phenotype

M. Sospedra, Roland Martin, S. Schippling, 2012, Journal of Neuroimmunology.

Effects of natalizumab therapy on intrathecal antiviral antibody responses in MS

I. Jelcic, I. Jelcic, M. Sospedra, 2019, Neurology: Neuroimmunology & Neuroinflammation.

Gender differences in circulating levels of neutrophil extracellular traps in serum of multiple sclerosis patients

M. Sospedra, Roland Martin, S. Schippling, 2013, Journal of Neuroimmunology.

Sustained Efficacy of Natalizumab in the Treatment of Relapsing-Remitting Multiple Sclerosis Independent of Disease Activity and Disability at Baseline: Real-Life Data From a Swiss Cohort

B. Zörner, M. Weller, I. Jelcic, 2012, Clinical neuropharmacology.

Altered CSF Albumin Quotient Links Peripheral Inflammation and Brain Damage in MS

T. Hornemann, I. Jelcic, W. Faigle, 2021, Neurology: Neuroimmunology & Neuroinflammation.

EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-γ and IL-2

J. Lünemann, I. Jelcic, A. Lutterotti, 2008, The Journal of experimental medicine.

Multiple Sclerosis Support the Etiologic Role of DRB5*01:01 in TCR/HLA-DRB5*01:01 Transgenic Mice Myelin Basic Protein-Specific

C. Pinilla, Roland Martin, H. McFarland, 2012 .

Individual TCR Signaling Events Ligands : Relationship to the Quality of Down-Modulation by Peptide : MHC Molecule Serial TCR Engagement and

R. Germain, Roland Martin, B. Hemmer, 1999 .

Different requirements of ICAM‐1/LFA‐1 adhesion in allorecognition and self‐restricted antigen recognition by class II‐specific T cell clones

Roland Martin, D. Jaraquemada, M. Martı́, 1994, European journal of immunology.

Spotlight on anti-CD25: daclizumab in MS.

Roland Martin, Dr Sven Schippling, 2008, International MS journal.

Skewed T-cell receptor repertoire in genetically identical twins correlates with multiple sclerosis

U. Utz, Roland Martin, D. McFarlin, 1993, Nature.

Virus-specific and autoreactive T cell lines isolated from cerebrospinal fluid of a patient with chronic rubella panencephalitis☆

Roland Martin, S. O'shea, M. Borkenstein, 1989, Journal of Neuroimmunology.

T-cell response to myelin basic protein and lipid-bound myelin basic protein in patients with multiple sclerosis and healthy donors

L. Amaducci, Roland Martin, H. McFarland, 1998, Journal of Neuroimmunology.

The TCR/peptide/MHC complex with a superagonist peptide shows similar interface and reduced flexibility compared to the complex with a self-peptide

A. Caflisch, Roland Martin, Ilaria Salutari, 2019, bioRxiv.

The 3A6‐TCR/superagonist/HLA‐DR2a complex shows similar interface and reduced flexibility compared to the complex with self‐peptide

A. Caflisch, Roland Martin, Ilaria Salutari, 2019, Proteins.

Cerebrospinal fluid chitinase 3-like 1 levels are associated with conversion to multiple sclerosis.

À. Rovira, X. Montalban, M. Tintoré, 2010, Brain : a journal of neurology.

Serum CD95 of relapsing remitting multiple sclerosis patients protects from CD95-mediated apoptosis

J. Dichgans, M. Weller, F. Zipp, 1998, Journal of Neuroimmunology.

Chemokines in chronic progressive neurological associated myelopathy and diseases: mu1 t ip le HTLV-1 sclerosis

P. Calabresi, Roland Martin, S. Jacobson, 1999 .

Chemokines in chronic progressive neurological multiple sclerosis

P. Calabresi, Roland Martin, S. Jacobson, 1999 .

Restoring immune tolerance in neuromyelitis optica

J. M. Behne, Terry J. Smith, Jeffrey A. Cohen, 2016, Neurology: Neuroimmunology & Neuroinflammation.

Myelin-Associated Oligodendrocytic Basic Protein: Identification of an Encephalitogenic Epitope and Association with Multiple Sclerosis1

Roland Martin, M. Oldstone, B. Bielekova, 2000, The Journal of Immunology.

Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87–99)

U. Utz, L. Steinman, Roland Martin, 1996, European journal of immunology.

Multiple sclerosis: doubling down on MHC.

T. Olsson, M. Sospedra, Roland Martin, 2021, Trends in genetics : TIG.

Recognition of Conserved Amino Acid Motifs of Common Viruses and Its Role in Autoimmunity

E. de Villiers, C. Pinilla, M. Sospedra, 2005, PLoS pathogens.

Sclerosis Epitope and Association with Multiple EncephalitogenicProtein : Identification of an Myelin-Associated Oligodendrocytic

Roland Martin, B. Bielekova, A. Holz, 1999 .

Neutralisation of IL12 p40 or IL23 p40 does not block inflammation in multiple sclerosis

Roland Martin, 2008, The Lancet Neurology.

Clonotypic analysis of cerebrospinal fluid T cells during disease exacerbation and remission in a patient with multiple sclerosis

M. Sospedra, Roland Martin, P. Muraro, 2006, Journal of Neuroimmunology.

Unfavorable Structural and Functional Outcomes in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Optic Neuritis

James V. M. Hanson, M. Weller, M. Pless, 2019, Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society.

Central role of JC virus-specific CD4+ lymphocytes in progressive multi-focal leucoencephalopathy-immune reconstitution inflammatory syndrome.

L. Jones, G. Ogg, I. Jelcic, 2011, Brain : a journal of neurology.

Borrelia burgdorferi Induces TLR1 and TLR2 in Human Microglia and Peripheral Blood Monocytes but Differentially Regulates HLA-Class II Expression

P. Munson, J. Lünemann, Roland Martin, 2006, Journal of neuropathology and experimental neurology.

Dynamics of Inflammatory and Neurodegenerative Biomarkers after Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis

I. Jelcic, Roland Martin, J. Kuhle, 2022, International journal of molecular sciences.

Receptor CD 26 Autoimmunity through the Inhibitory Nervous System Inflammation and 1-Mediated Control of Central β TGF-and

D. Marguet, Roland Martin, B. Schraven, 2007 .

Targeting Dipeptidyl Peptidase IV (CD26) Suppresses Autoimmune Encephalomyelitis and Up-Regulates TGF-β1 Secretion In Vivo1

Roland Martin, L. Izikson, N. Tresser, 2001, The Journal of Immunology.

Secretion In Vivo β and UpRegulates TGF-Suppresses Autoimmune Encephalomyelitis Targeting Dipeptidyl Peptidase IV ( CD 26 )

Roland Martin, L. Izikson, N. Tresser, 2001 .

the Quality of Early Signaling Events in Human T Thresholds for Effector Function Elicitation, and Relationships Among TCR Ligand Potency,

Roland Martin, B. Hemmer, M. Vergelli, 2017 .

I-Associated Neurological Disease Human T Lymphotropic Virus Type Antigen-Specific T Cells of Patients with An Altered Peptide Ligand Antagonizes

Roland Martin, S. Jacobson, S. Soldan, 2000 .

The antibody repertoire in experimental allergic neuritis: evidence for PMP-22 as a novel neuritogen

Roland Martin, H. Wiethölter, Niklas K. U. Koehler, 1996, Journal of Neuroimmunology.

HLA-DRB5*0101 and -DRB1*1501 expression in the multiple sclerosis-associated HLA-DR15 haplotype

Deric M. Park, Roland Martin, N. Kruse, 2005, Journal of Neuroimmunology.

Genome-wide Scan of 500000 Single-Nucleotide Polymorphisms Among Responders and Nonresponders to Interferon Beta Therapy in Multiple Sclerosis

D. Craig, X. Montalban, A. Navarro, 2009 .

Prevention and therapy of JC polyomavirus-mediated progressive multifocal leukoencephalopathy - a realistic possibility?

I. Jelcic, I. Jelcic, M. Sospedra, 2017, Swiss medical weekly.

Anti-CD25 (daclizumab) monoclonal antibody therapy in relapsing-remitting multiple sclerosis.

Roland Martin, Roland Martin, Roland Martin, 2012, Clinical immunology.

Broadly neutralizing human monoclonal JC polyomavirus VP1–specific antibodies as candidate therapeutics for progressive multifocal leukoencephalopathy

B. Reinhart, R. Nitsch, I. Jelcic, 2015, Science Translational Medicine.

Mechanisms of immune escape in central nervous system infection with neurotropic JC virus variant

H. Budka, I. Jelcic, R. Planas, 2016, Annals of neurology.

Borrelia burgdorferi lipoprotein-mediated TLR2 stimulation causes the down-regulation of TLR5 in human monocytes.

P. Munson, Roland Martin, H. Gelderblom, 2006, The Journal of infectious diseases.

Glatiramer acetate-reactive peripheral blood mononuclear cells respond to multiple myelin antigens with a Th2-biased phenotype

M. Zhan, Roland Martin, Kenneth P. Johnson, 2003, Journal of Neuroimmunology.

Selected cytotoxic T lymphocytes with high specificity for HTLV-I in cerebrospinal fluid from a HAM/TSP patient

Roland Martin, S. Jacobson, S. Soldan, 2011, Journal of NeuroVirology.

Multiple sclerosis: Closing in on an oral treatment

Roland Martin, 2010, Nature.

Autoantigens act as tissue‐specific chemoattractants

Roland Martin, P. Plotz, S. Pierce, 2005, Journal of leukocyte biology.

A functional basis for the association of HLA class II genes adn susceptibility to multiple sclerosis: cellular immune responses to myelin basic protein in a multiplex family

Roland Martin, H. McFarland, R. Voskuhl, 1993, Journal of Neuroimmunology.

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand

J. Frank, Roland Martin, H. McFarland, 2000, Nature Medicine.

Antibody responses following induction of antigen-specific tolerance with antigen-coupled cells

A. Lutterotti, M. Sospedra, Roland Martin, 2015, Multiple sclerosis.

Dynamics of T cell repertoire renewal following autologous hematopoietic stem cell transplantation in multiple sclerosis

I. Jelcic, Roland Martin, A. Müller, 2022, Science Translational Medicine.

Therapeutic Potential of Phosphodiesterase-4 and -3 Inhibitors in Th1-Mediated Autoimmune Diseases

Roland Martin, B. Bielekova, Anne Lincoln, 2000, The Journal of Immunology.

New drugs may improve, complicate treatment for multiple sclerosis

Roland Martin, H. Link, 2010, Nature Medicine.

Myelin basic protein‐specific T‐cell responses in identical twins discordant or concordant for multiple sclerosis

Roland Martin, D. McFarlin, H. McFarland, 1993, Annals of neurology.

Differential effects of phosphodiesterase type 4-specific inhibition on human autoreactive myelin-specific T cell clones

Roland Martin, H. McFarland, P. Muraro, 1999, Journal of Neuroimmunology.

Clearance of JC polyomavirus from cerebrospinal fluid following treatment with interleukin‐2 and pembrolizumab in an individual with progressive multifocal leukoencephalopathy and no underlying immune deficiency syndrome

G. Fink, A. Wellstein, Roland Martin, 2020, European Journal of Neurology.

Natalizumab treatment perturbs memory‐ and marginal zone‐like B‐cell homing in secondary lymphoid organs in multiple sclerosis

R. Planas, I. Jelcic, M. Sospedra, 2012, European journal of immunology.

A plea for “Omics” research in complex diseases such as multiple sclerosis—a change of mind is needed

Roland Martin, D. Leppert, 2004, Journal of the Neurological Sciences.

Clinical and neuroimmunological findings in chronic Borrelia burgdorferi radiculomyelitis (Lyme disease)

Roland Martin, H. Mertens, W. Kohlhepp, 1988, Journal of Neuroimmunology.

Role of interleukin 10 during persistent infection with the relapsing fever Spirochete Borrelia turicatae.

Roland Martin, H. Gelderblom, D. Cadavid, 2007, The American journal of pathology.

Research opportunities on human neuroborreliosis.

Roland Martin, H. Gelderblom, A. Marques, 2004, Vector borne and zoonotic diseases.

Lack of over-expression of T cell receptor Vβ5.2 in myelin basic protein-specific T cell lines derived from HLA-DR2 positive multiple sclerosis patients and controls

Roland Martin, H. McFarland, P. Muraro, 1998, Journal of Neuroimmunology.

In vitro modulation of human, autoreactive MBP-specific CD4+ T-cell clones by cyclosporin A

Roland Martin, H. McFarland, P. Muraro, 1997, Journal of Neuroimmunology.

Combinatorial peptide libraries and molecular recognition in T-cell mediated immune response

Roland Martin, K. Wiesmüller, B. Fleckenstein, 1999 .

Immunology of Multiple Sclerosis

M. Sospedra, Roland Martin, 2016, Seminars in Neurology.

2′,3′-cyclic nucleotide 3′-phosphodiesterase: a novel candidate autoantigen in demyelinating diseases

Roland Martin, H. McFarland, R. Lichtenfels, 1997, Journal of Neuroimmunology.

Interferon-γ secretion by in vivo activated cytotoxic T lymphocytes from the blood and cerebrospinal fluid during mumps meningitis

Roland Martin, A. Vallbracht, H. Kreth, 1991, Journal of Neuroimmunology.

Training-dependent plasticity in patients with multiple sclerosis.

Alessandro Tessitore, Katrin Morgen, Lumy Sawaki, 2004, Brain : a journal of neurology.

Use of combinatorial peptide libraries for T-cell epitope mapping.

C. Pinilla, M. Sospedra, Roland Martin, 2003, Methods.

Erratum: Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon β (Proceedings of the National Academy of Sciences of the United States of America (June 8, 2004) 101:23 (8705-8708))

T. Waldmann, J. Frank, Roland Martin, 2004 .

CD46 on glial cells can function as a receptor for viral glycoprotein‐mediated cell–cell fusion

Roland Martin, E. Martinelli, S. Jacobson, 2005, Glia.

Clinically Isolated Neurosarcoidosis: A Recommended Diagnostic Path

M. Weller, A. Valavanis, Roland Martin, 2014, European Neurology.

Stem cell transplantation in multiple sclerosis

A. Zander, Roland Martin, S. Schippling, 2008, Journal of Neurology.

Dendritic cells signal T cells in the absence of exogenous antigen

Roland Martin, I. Cortese, T. Kondo, 2001, Nature Immunology.

Characterization of Antigen-Induced CD4+ T-Cell Senescence in Multiple Sclerosis

M. Sospedra, Roland Martin, M. Docampo, 2022, Frontiers in Neurology.

T-Cell Specificity Influences Disease Heterogeneity in Multiple Sclerosis

R. Opfer, I. Jelcic, R. Planas, 2021, Neurology: Neuroimmunology & Neuroinflammation.

Central role of Th2/Tc2 lymphocytes in pattern II multiple sclerosis lesions

W. Brück, R. Planas, I. Jelcic, 2015, Annals of clinical and translational neurology.

Chapter 53 – Multiple Sclerosis

Roland Martin, R. Hohlfeld, H. McFarland, 2003 .

The initiation of the autoimmune response in multiple sclerosis

C. Pinilla, Roland Martin, S. Markovic‐Plese, 2004, Clinical Neurology and Neurosurgery.

Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy.

L. Steinman, Roland Martin, J. Oksenberg, 2002, Annual review of neuroscience.

Treating progressive multifocal leukoencephalopathy with interleukin 7 and vaccination with JC virus capsid protein VP1.

R. Planas, I. Jelcic, M. Sospedra, 2014, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

The good and the bad of neuroinflammation in multiple sclerosis.

Roland Martin, M. Naegele, 2014, Handbook of clinical neurology.

Non-myeloablative autologous haematopoietic stem cell transplantation expands regulatory cells and depletes IL-17 producing mucosal-associated invariant T cells in multiple sclerosis.

P. Calabresi, R. Reynolds, Roland Martin, 2013, Brain : a journal of neurology.

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

Bernhard Hemmer, Ronald N. Germain, Roland Martin, 2003, Nature Immunology.

T Lymphocyte Priming by Neutrophil Extracellular Traps Links Innate and Adaptive Immune Responses

M. Sospedra, Roland Martin, P. Breiden, 2012, The Journal of Immunology.

Boswellic acids reduce Th17 differentiation via blockade of IL‐1β‐mediated IRAK1 signaling

M. Sospedra, Roland Martin, K. Stürner, 2014, European journal of immunology.

Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis.

Arcadi Navarro, Xavier Montalban, Manuel Comabella, 2009, Archives of neurology.

Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis

B. Engelhardt, M. Sospedra, Roland Martin, 2016, European journal of immunology.

Human CD4+ T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro

B. Engelhardt, M. Sospedra, Roland Martin, 2020, Fluids and Barriers of the CNS.

Up-regulation of inducible heat shock protein-70 expression in multiple sclerosis patients

X. Montalban, Roland Martin, J. Río, 2014, Autoimmunity.

Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system.

B. Becher, A. Mildner, K. Knobeloch, 2008, Immunity.

A standardised frankincense extract reduces disease activity in relapsing-remitting multiple sclerosis (the SABA phase IIa trial)

T. Friede, F. Paul, J. Dörr, 2017, Journal of Neurology, Neurosurgery, and Psychiatry.

HLA Ligand Atlas: a benign reference of HLA-presented peptides to improve T-cell-based cancer immunotherapy

H. Rammensee, S. Stevanović, M. Weller, 2021, Journal for ImmunoTherapy of Cancer.

Identification of High Potency Microbial and Self Ligands for a Human Autoreactive Class II–restricted T Cell Clone

Bernhard Hemmer, Günther Jung, Karl-Heinz Wiesmüller, 1997, The Journal of experimental medicine.

Antigen-Specific Tolerance by Autologous Myelin Peptide–Coupled Cells: A Phase 1 Trial in Multiple Sclerosis

A. Lutterotti, M. Sospedra, Roland Martin, 2013, Science Translational Medicine.

Structure of a human autoimmune TCR bound to a myelin basic protein self‐peptide and a multiple sclerosis‐associated MHC class II molecule

Roland Martin, Roland Martin, R. Mariuzza, 2005, The EMBO journal.

Myelin Basic Protein-Specific TCR/HLA-DRB5*01:01 Transgenic Mice Support the Etiologic Role of DRB5*01:01 in Multiple Sclerosis

C. Pinilla, Roland Martin, H. McFarland, 2012, The Journal of Immunology.

Chapter 4 Immunology of Multiple Sclerosis

Roland Martin, 2003 .

Molecular mimicry and multiple sclerosis: Degenerate T‐cell recognition and the induction of autoimmunity

Roland Martin, B. Hemmer, H. McFarland, 1999, Annals of neurology.

CD95 expression and CD95-mediated apoptosis of T cells in multiple sclerosis No differences from normal individuals and no relation to HLA-DR2

J. Dichgans, M. Weller, F. Zipp, 1998, Journal of Neuroimmunology.

Differential Expression of Serum Extracellular Vesicle miRNAs in Multiple Sclerosis: Disease-Stage Specificity and Relevance to Pathophysiology

G. Russo, Roland Martin, I. Knuesel, 2022, International journal of molecular sciences.

GDP-l-fucose synthase is a CD4+ T cell–specific autoantigen in DRB3*02:02 patients with multiple sclerosis

Radleigh G. Santos, R. Planas, W. Faigle, 2018, Science Translational Medicine.

Daclizumab (anti-CD25) in multiple sclerosis

Roland Martin, N. Pfender, Nikolai Pfender, 2014, Experimental Neurology.

A molecular view of multiple sclerosis and experimental autoimmune encephalitis: What can we learn from the epitope data?

Bjoern Peters, A. Sette, Roland Martin, 2014, Journal of Neuroimmunology.

Retinal Damage in Multiple Sclerosis Disease Subtypes Measured by High-Resolution Optical Coherence Tomography

F. Paul, H. Hartung, Roland Martin, 2012, Multiple sclerosis international.

Nogo-Receptors NgR1 and NgR2 Do Not Mediate Regulation of CD4 T Helper Responses and CNS Repair in Experimental Autoimmune Encephalomyelitis

Roland Martin, C. Bandtlow, Rüdiger Schweigreiter, 2011, PloS one.

Humanized Anti-CD25 Antibody Treatment with Daclizumab in Multiple Sclerosis

Roland Martin, 2007, Neurodegenerative Diseases.

Epstein-Barr Virus: Environmental Trigger of Multiple Sclerosis?

J. Lünemann, Roland Martin, T. Kamradt, 2007, Journal of Virology.

TGF-β1-Mediated Control of Central Nervous System Inflammation and Autoimmunity through the Inhibitory Receptor CD261

D. Marguet, Roland Martin, B. Schraven, 2007, The Journal of Immunology.

Roland Martin and of Multiple Sclerosis ? Epstein-Barr Virus : Environmental Trigger

J. Lünemann, Roland Martin, T. Kamradt, 2007 .

The value of animal models for drug development in multiple sclerosis.

X. Montalban, L. Fugger, J. Bell, 2006, Brain : a journal of neurology.

Increased frequency and broadened specificity of latent EBV nuclear antigen-1-specific T cells in multiple sclerosis.

J. Lünemann, Roland Martin, N. Edwards, 2006, Brain : a journal of neurology.

Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients

D. Douek, J. Nagle, Roland Martin, 2005, The Journal of experimental medicine.

Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis

Lawrence Steinman, Tomas Olsson, Paul J Utz, 2003, Nature Biotechnology.

Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease.

Javed Khan, Markus Ringnér, Michael L Bittner, 2003, Human molecular genetics.

Is multiple sclerosis progression associated with the HLA-DR15 haplotype?

Roland Martin, B. Fehse, C. Heesen, 2019, Multiple sclerosis journal - experimental, translational and clinical.

HLA-DR15-derived self-peptides are involved in increased autologous T cell proliferation in multiple sclerosis.

M. Okoniewski, H. Rammensee, S. Stevanović, 2013, Brain : a journal of neurology.

Redundancy in Antigen-Presenting Function of the HLA-DR and -DQ Molecules in the Multiple Sclerosis-Associated HLA-DR2 Haplotype1

R. Simon, M. Giulianotti, C. Pinilla, 2006, The Journal of Immunology.

Haplotype Multiple Sclerosis-Associated HLA-DR 2 of the HLA-DR and-DQ Molecules in the Redundancy in Antigen-Presenting Function

R. Simon, M. Giulianotti, C. Pinilla, 2006 .

HLA class I: friend and foe of multiple sclerosis

Roland Martin, 2008, Nature Medicine.

T cell receptor usage in neurological disease: the case in multiple sclerosis

Roland Martin, H. McFarland, 1992 .

Exploring the origins of grey matter damage in multiple sclerosis

O. Ciccarelli, R. Reynolds, Roland Martin, 2015, Nature Reviews Neuroscience.

Unique Clinical and Pathological Features in HLA-DRB1*0401–restricted MBP 111–129–specific Humanized TCR Transgenic Mice

S. Ludwin, Roland Martin, H. McFarland, 2004, The Journal of experimental medicine.

Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease

Yingdong Zhao, Clemencia Pinilla, Bernhard Hemmer, 1999, Nature Medicine.

Infectious causes of multiple sclerosis

G. Cutter, Roland Martin, G. Giovannoni, 2006, The Lancet Neurology.

A Truncation Variant of the Cation Channel P2RX5 Is Upregulated during T Cell Activation

O. Pongs, Roland Martin, Pierre Abramowski, 2014, PloS one.

Genomics in multiple sclerosis—Current state and future directions

Roland Martin, M. Comabella, 2007, Journal of Neuroimmunology.

Application of support vector machines for T-cell epitopes prediction

Yingdong Zhao, Clemencia Pinilla, Danila Valmori, 2003, Bioinform..

High Production of CXCL13 in Blood and Brain During Persistent Infection With the Relapsing Fever Spirochete Borrelia turicatae

Roland Martin, H. Gelderblom, D. Cadavid, 2007, Journal of neuropathology and experimental neurology.

Chapter 6 - Biomarkers in Multiple Sclerosis

I. Jelcic, Roland Martin, 2010 .

Biomarkers in Multiple Sclerosis

U. Utz, Roland Martin, R. Hohlfeld, 2006, Disease markers.

Molecular tracking of antigen-specific T cell clones in neurological immune-mediated disorders.

U. Utz, Roland Martin, H. McFarland, 2003, Brain : a journal of neurology.

Pharmacology of Inflammation

Roland Martin, C. Espejo, 2007 .

Molecular mimicry in multiple sclerosis

M. Sospedra, Roland Martin, 2006, Autoimmunity.

Peptides as Targets of T Cell-Mediated Immune Responses

Roland Martin, 2006 .

Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis.

T. Waldmann, M. Cerná, Roland Martin, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Mechanistic and Biomarker Studies to Demonstrate Immune Tolerance in Multiple Sclerosis

A. Lutterotti, M. Sospedra, Roland Martin, 2022, Frontiers in Immunology.

HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis

Nora C. Toussaint, H. Rammensee, S. Stevanović, 2020, Cell.

Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls.

Sandra D'Alfonso, Hanne F. Harbo, Bernhard Hemmer, 2013, American journal of human genetics.

JC polyomavirus mutants escape antibody-mediated neutralization

A. Lazzarin, Roland Martin, P. Cinque, 2015, Science Translational Medicine.

A Multiple Sclerosis–Associated Variant of CBLB Links Genetic Risk with Type I IFN Function

Roland Martin, C. Schulze, O. Pless, 2014, The Journal of Immunology.

Cerebrospinal Fluid-Infiltrating CD4+ T Cells Recognize Borrelia burgdorferi Lysine-Enriched Protein Domains and Central Nervous System Autoantigens in Early Lyme Encephalitis

J. Lünemann, C. Pinilla, M. Sospedra, 2006, Infection and Immunity.

1 CSF-Infiltrating CD 4 + T Cells Recognize Borrelia burgdorferi Lysine-Enriched Protein Domains And CNS Auto-Antigens In Early Lyme Encephalitis

J. Lünemann, C. Pinilla, M. Sospedra, 2006 .

High level of cross-reactivity in influenza virus hemagglutinin-specific CD4+ T-cell response: Implications for the initiation of autoimmune response in multiple sclerosis

R. Simon, C. Pinilla, Roland Martin, 2005, Journal of Neuroimmunology.

A powerful combination: the use of positional scanning libraries and biometrical analysis to identify cross-reactive T cell epitopes.

Clemencia Pinilla, Danila Valmori, Richard Simon, 2004, Molecular immunology.

Killer immunoglobulin-like receptor locus polymorphisms in multiple sclerosis

J. Lünemann, I. Jelcic, Roland Martin, 2012, Multiple sclerosis.

Central role of Th 2 / Tc 2 lymphocytes in pattern II multiple sclerosis lesions

R. Planas, Yaneth M. Ortiz, M. Sospedra, 2015 .

Attenuated immune control of Epstein–Barr virus in humanized mice is associated with the multiple sclerosis risk factor HLA‐DR15

J. Lünemann, Roland Martin, C. Münz, 2020, European journal of immunology.

Expansion and Functional Relevance of High-Avidity Myelin-Specific CD4+ T Cells in Multiple Sclerosis

R. Simon, Roland Martin, H. McFarland, 2004, The Journal of Immunology.

Immunization with a cannabinoid receptor type 1 peptide results in experimental allergic meningocerebellitis in the Lewis rat: A model for cell‐mediated autoimmune neuropathology

M. Herkenham, Roland Martin, M. Proescholdt, 2002, Journal of neuroscience research.

Complex immunomodulatory effects of interferon‐β in multiple sclerosis include the upregulation of T helper 1‐associated marker genes

L. Staudt, A. Rosenwald, Roland Martin, 2001, Annals of neurology.

Functional HLA‐DM on the surface of B cells and immature dendritic cells

Dirk Schadendorf, Gerhard Moldenhauer, Yuansheng Sun, 2000, The EMBO journal.

Neurological manifestations of coronavirus infections – a systematic review

F. Piehl, Roland Martin, T. Granberg, 2020, medRxiv.

Magnetic resonance imaging of labeled T‐cells in a mouse model of multiple sclerosis

Roland Martin, Joseph Frank, H. McFarland, 2004, Annals of neurology.

CD 4 + CD 28 – costimulation-independent T cells in multiple sclerosis

Roland Martin, H. McFarland, I. Cortese, 2001 .

Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk

H. Ullum, T. Werge, H. Hakonarson, 2018, Cell.

Longitudinal study of myelin basic protein-specific T-cell receptors during the course of multiple sclerosis

U. Utz, Roland Martin, H. McFarland, 1997, Journal of Neuroimmunology.

Experimental immunotherapies for multiple sclerosis

Roland Martin, H. McFarland, 2004, Springer Seminars in Immunopathology.

Different Development of Myelin Basic Protein Agonist- and Antagonist-Specific Human TCR Transgenic T Cells in the Thymus and Periphery1

Roland Martin, H. McFarland, A. Necker, 2008, The Journal of Immunology.

Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: Implications for the initiation of the autoimmune response in multiple sclerosis

C. Pinilla, M. Sospedra, Roland Martin, 2008, European journal of immunology.

Cystatin F is a biomarker of prion pathogenesis in mice

A. Aguzzi, H. Budka, Roland Martin, 2017, PloS one.

Contribution of Individual Amino Acids Within MHC Molecule or Antigenic Peptide to TCR Ligand Potency1

Clemencia Pinilla, Bernhard Hemmer, Henry F. McFarland, 2000, The Journal of Immunology.

T-Cell Epitope Prediction with Combinatorial Peptide Libraries

Yingdong Zhao, Richard Simon, Myong-Hee Sung, 2003, J. Comput. Biol..

Antigen-specific immunomodulation via altered peptide ligands

Roland Martin, Bibiana Bielekova, Roland Martin, 2001, Journal of Molecular Medicine.

Immunology of progressive multifocal leukoencephalopathy

I. Jelcic, I. Jelcic, W. Faigle, 2015, Journal of NeuroVirology.

TCR Bias and HLA Cross-Restriction Are Strategies of Human Brain-Infiltrating JC Virus-Specific CD4+ T Cells during Viral Infection

R. Planas, M. Sospedra, Roland Martin, 2012, The Journal of Immunology.

Infection T Cells during Viral + Virus-Specific CD 4 Strategies of Human Brain-Infiltrating JC TCR Bias and HLA Cross-Restriction Are Eiermann

R. Planas, M. Sospedra, Roland Martin, 2012 .

Findings on T cell specificity revealed by synthetic combinatorial libraries.

Yingdong Zhao, Clemencia Pinilla, Danila Valmori, 2002, Journal of immunological methods.

PWE-066 Clinical features of demyelination during anti-tnf therapy: preliminary outcomes of the pred4 study

J. Hobart, Roland Martin, A. Coles, 2017, Gut.

Combining positional scanning peptide libraries, HLA-DR transfectants and bioinformatics to dissect the epitope spectrum of HLA class II cross-restricted CD4+ T cell clones.

R. Simon, M. Giulianotti, C. Pinilla, 2010, Journal of immunological methods.

Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon beta.

T. Waldmann, J. Frank, Roland Martin, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Mesenchymal Stromal/Stem Cells Do Not Ameliorate Experimental Autoimmune Encephalomyelitis and Are Not Detectable in the Central Nervous System of Transplanted Mice.

A. Zander, Roland Martin, M. Schweizer, 2016, Stem cells and development.

Hematopoietic stem cell transplantation for multiple sclerosis: collaboration of the CIBMTR and EBMT to facilitate international clinical studies.

D. Arnold, H. Atkins, G. Kraft, 2010, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Is haematopoietic stem cell transplantation a treatment option for severe MS or not?

Roland Martin, 2007, Brain : a journal of neurology.

Increased HLA-DR expression and cortical demyelination in MS links with HLA-DR15

U. Certa, Guido Steiner, Roland Martin, 2019, Neurology: Neuroimmunology & Neuroinflammation.

Whole Genome Sequencing Reveals a Chromosome 9p Deletion Causing DOCK8 Deficiency in an Adult Diagnosed with Hyper IgE Syndrome Who Developed Progressive Multifocal Leukoencephalopathy

J. Carulli, I. Jelcic, Roland Martin, 2014, Journal of Clinical Immunology.

Peptide Ligands T Cells and Induce T Cell Responses to Native + Identify Epitopes That Activate Clonotypic CD4 Immunogenicity. I. Use of Peptide Libraries to

C. Pinilla, Roland Martin, B. Hemmer, 2011 .

Multiple Sclerosis T Cells + High-Avidity Myelin-Specific CD 4 Expansion and Functional Relevance of

R. Simon, Roland Martin, H. McFarland, 2004 .

Dynamics and heterogeneity of brain damage in multiple sclerosis

Roland Martin, Pablo Villoslada, Jesper Tegnér, 2017, PLoS Comput. Biol..

Treatment with the phosphodiesterase type-4 inhibitor rolipram fails to inhibit blood—brain barrier disruption in multiple sclerosis

Roland Martin, H. McFarland, N. Richert, 2009, Multiple sclerosis.

Future immunotherapies in multiple sclerosis.

Roland Martin, G. Blevins, 2003, Seminars in neurology.

Antigen-specific tolerization approaches in multiple sclerosis

A. Lutterotti, Roland Martin, 2014, Expert opinion on investigational drugs.

Sphingosine-1 phosphate and central nervous system.

M. Sospedra, Roland Martin, 2014, Current topics in microbiology and immunology.

Antigen-Specific Immune Tolerance in Multiple Sclerosis—Promising Approaches and How to Bring Them to Patients

A. Lutterotti, M. Sospedra, Roland Martin, 2021, Frontiers in Immunology.

NK Cells and Innate-Like T Cells After Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis

I. Jelcic, Roland Martin, A. Müller, 2021, Frontiers in Immunology.

Phenotypic and functional complexity of brain-infiltrating T cells in Rasmussen encephalitis

H. Budka, I. Jelcic, F. Al Nimer, 2017, Neurology: Neuroimmunology & Neuroinflammation.

Anti-myelin antibody responses following induction of antigen-specific tolerance with antigen-coupled cells

A. Lutterotti, M. Sospedra, Roland Martin, 2014, Journal of Neuroimmunology.

Long-term safety and efficacy of natalizumab in relapsing-remitting multiple sclerosis: impact on quality of life

R. Planas, M. Sospedra, Roland Martin, 2014, Patient related outcome measures.

Effect of anti-CD25 antibody daclizumab in the inhibition of inflammation and stabilization of disease progression in multiple sclerosis.

T. Waldmann, Roland Martin, H. McFarland, 2009, Archives of neurology.

Increased serum levels of soluble CD95 (APO‐1/Fas) in relapsing‐remitting multiple sclerosis

J. Dichgans, P. Calabresi, F. Zipp, 1998, Annals of neurology.

Getting specific: monoclonal antibodies in multiple sclerosis

A. Lutterotti, Roland Martin, 2008, The Lancet Neurology.

Interleukin 4 treatment of psoriasis: are pleiotropic cytokines suitable therapies for autoimmune diseases?

Roland Martin, Roland Martin, 2003, Trends in pharmacological sciences.

Nogo-A Antibodies for Progressive Multiple Sclerosis

M. Schwab, Roland Martin, B. Ineichen, 2017, CNS Drugs.

Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis

B. Roschitzki, I. Jelcic, W. Faigle, 2019, Front. Immunol..

Using gadolinium‐enhanced magnetic resonance imaging lesions to monitor disease activity in multiple sclerosis

Roland Martin, J. Frank, Roland Martin, 1992, Annals of neurology.

Hematopoietic stem cell transplantation for multiple sclerosis: current status and future challenges.

Roland Martin, P. Muraro, Riccardo Cassiani Ingoni, 2003, Current opinion in neurology.

Nogo-A antibodies enhance axonal repair and remyelination in neuro-inflammatory and demyelinating pathology

B. Zörner, M. Schwab, Roland Martin, 2017, Acta Neuropathologica.

Short-term MRI measurements as predictors of EDSS progression in relapsing-remitting multiple sclerosis: grey matter atrophy but not lesions are predictive in a real-life setting

Roland Martin, S. Schippling, C. Heesen, 2016, PeerJ.

Placebo Cohorts in Phase-3 MS Treatment Trials – Predictors for On-Trial Disease Activity 1990-2010 Based on a Meta-Analysis and Individual Case Data

Roland Martin, M. Daumer, S. Schippling, 2012, PloS one.

Effects of natalizumab treatment on the cerebrospinal fluid proteome of multiple sclerosis patients.

T. Olsson, M. Khademi, Roland Martin, 2013, Journal of proteome research.

Immunotherapy of multiple sclerosis: Where are we? Where should we go?

Roland Martin, H. McFarland, C. Stürzebecher, 2001, Nature Immunology.

Limited repertoire of HLA-DRB1*0401-restricted MBP111–129-specific T cells in HLA-DRB1*0401 Tg mice and their pathogenic potential

S. Ludwin, Roland Martin, H. McFarland, 2004, Journal of Neuroimmunology.

Reactivation of herpesvirus under fingolimod: A case of severe herpes simplex encephalitis

I. Jelcic, Roland Martin, M. Linnebank, 2015, Neurology.

Multiple sclerosis: Immunotherapy

Roland Martin, B. Bielekova, 1999, Current treatment options in neurology.

Human Autoreactive CD4+ T Cells from Naive CD45RA+ and Memory CD45RO+ Subsets Differ with Respect to Epitope Specificity and Functional Antigen Avidity

Roland Martin, H. McFarland, B. Bielekova, 2000, The Journal of Immunology.

Specificity and Functional Antigen Avidity Subsets Differ with Respect to Epitope + and Memory CD 45 RO + Naive CD 45 RA T Cells from + Human Autoreactive CD 4

Roland Martin, H. McFarland, B. Bielekova, 2000 .

Antigen-specific therapies in MS — Current concepts and novel approaches

A. Lutterotti, M. Sospedra, Roland Martin, 2008, Journal of the Neurological Sciences.

Effect of Anti-CD 25 Antibody Daclizumab in the Inhibition of Inflammation and Stabilization of Disease Progression in Multiple Sclerosis

T. Waldmann, Roland Martin, H. McFarland, 2009 .

A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis

Till F. M. Andlauer, J. Haines, M. Pericak-Vance, 2019, Nature Communications.

Structure of a TCR with high affinity for self‐antigen reveals basis for escape from negative selection

Roland Martin, Roland Martin, R. Mariuzza, 2011, The EMBO journal.

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

M. Pirinen, P. Donnelly, C. Spencer, 2013, Nature Genetics.

Tocilizumab treatment in severe recurrent anti-MOG-associated optic neuritis

Roland Martin, S. Schippling, M. Reindl, 2019, Neurology.

Biomarkers in multiple sclerosis: an update for 2014.

À. Rovira, X. Montalban, Roland Martin, 2014, Revista de neurología (Ed. impresa).

Intrathecal effects of daclizumab treatment of multiple sclerosis

T. Waldmann, Roland Martin, H. McFarland, 2011, Neurology.

Restoring immune tolerance in neuromyelitis optica

J. M. Behne, Terry J. Smith, Jacqueline Palace, 2016, Neurology: Neuroimmunology & Neuroinflammation.

Targeting fibrin in neurodegeneration

Roland Martin, 2018, Nature Immunology.

Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk

Till F. M. Andlauer, H. Ullum, T. Werge, 2018, Cell.

Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: Implications for the initiation of the autoimmune response in multiple sclerosis

C. Pinilla, M. Sospedra, Roland Martin, 2008, European journal of immunology.

Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls.

H. Hakonarson, M. Pericak-Vance, M. Ban, 2013, American journal of human genetics.

Non-myeloablative autologous haematopoietic stem cell transplantation expands regulatory cells and depletes IL-17 producing mucosal-associated invariant T cells in multiple sclerosis.

P. Calabresi, R. Reynolds, Roland Martin, 2013, Brain : a journal of neurology.

The affinity spedrum of myelin basic protein-reactive T cells

Roland Martin, B. Hemmer, M. Vergelli, 1999 .

The affinity spectrum of myelin basic protein-reactive T cells

Roland Martin, B. Hemmer, M. Vergelli, 1999 .

2′,3′-cyclic nucleotide 3′-phosphodiesterase: a novel candidate autoantigen in demyelinating diseases

Roland Martin, H. McFarland, R. Lichtenfels, 1997, Journal of Neuroimmunology.

Immunological Aspects of Multiple Sclerosis with Emphasis on the Potential Use of Autologous Hemopoietic Stem Cell Transplantation

Roland Martin, H. McFarland, P. Muraro, 2019, Stem Cell Therapy for Autoimmune Disease.

R. Planas, M. Sospedra, Roland Martin, 2022 .

EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-γ and IL-2

J. Lünemann, I. Jelcic, A. Lutterotti, 2008, The Journal of experimental medicine.