H. Wiendl

H. Wiendl, K. Lorenz, S. Meuth, 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Blocking of α 4 Integrin Does Not Protect From Acute Ischemic Stroke in Mice

H. Wiendl, S. Meuth, M. Gelderblom, 2014 .

Volume regulation of murine T lymphocytes relies on voltage-dependent and two-pore domain potassium channels.

H. Wiendl, S. Meuth, S. Hartmann, 2011, Biochimica et biophysica acta.

ORAL PRESENTATIONS

Danica, D. Bayliss, R. Mutani, 2003, British Journal of Cancer.

Protective potential of dimethyl fumarate in a mouse model of thalamocortical demyelination

H. Pape, E. Speckmann, H. Wiendl, 2018, Brain Structure and Function.

Recent clinical trials and future therapies

H. Wiendl, S. Meuth, C. Kleinschnitz, 2008, Journal of Neurology.

Dual action by fumaric acid esters synergistically reduces adhesion to human endothelium

H. Wiendl, C. Gross, A. Zarbock, 2018, Multiple sclerosis.

Kinetics of IL-6 Production Defines T Effector Cell Responsiveness to Regulatory T Cells in Multiple Sclerosis

F. Zipp, H. Wiendl, J. Haas, 2013, PloS one.

Specific loss of cellular L-selectin on CD4+ T cells is associated with progressive multifocal leukoencephalopathy development during HIV infection

H. Wiendl, I. Husstedt, Konstanze Philipp, 2014, AIDS.

Response to letter regarding article, "blocking of α4 integrin does not protect from acute ischemic stroke in mice".

H. Wiendl, C. Kleinschnitz, F. Langhauser, 2014, Stroke.

Con: Regulatory T cells are protective in ischemic stroke.

H. Wiendl, C. Kleinschnitz, 2013, Stroke.

The level of B7 homologue 1 expression on brain DC is decisive for CD8 Treg cell recruitment into the CNS during EAE

H. Wiendl, Z. Fabry, A. Zozulya, 2009, European journal of immunology.

An Enigmatic Case of Acute Mercury Poisoning: Clinical, Immunological Findings and Platelet Function

H. Wiendl, S. Meuth, C. Gross, 2017, Front. Neurol..

Long-Term Sonographical Follow-Up of Arterial Stenosis Due to Spontaneous Cervical Artery Dissection

W. Schwindt, H. Wiendl, J. Minnerup, 2022, Frontiers in Neurology.

Association of obesity with disease outcome in multiple sclerosis

J. Lünemann, F. Zipp, B. Hemmer, 2022, Journal of Neurology, Neurosurgery, and Psychiatry.

Dysphagia in neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody disease as a surrogate of brain involvement?

H. Wiendl, S. Meuth, T. Warnecke, 2021 .

NMO Spectrum Disorders

H. Wiendl, S. Pfeuffer, C. Strippel, 2017, Neurology International Open.

NMO-Spektrum-Erkrankungen

H. Wiendl, S. Pfeuffer, 2016, Aktuelle Neurologie.

Early Reduction of MRI Activity During 6 Months of Treatment With Cladribine Tablets for Highly Active Relapsing Multiple Sclerosis

F. Barkhof, L. Leocani, X. Montalban, 2022, Neurology: Neuroimmunology & Neuroinflammation.

Benefit–Risk Profile of Sphingosine-1-Phosphate Receptor Modulators in Relapsing and Secondary Progressive Multiple Sclerosis

H. Hartung, G. Comi, H. Wiendl, 2017, Drugs.

Transforming multiple sclerosis trials into practical reality

H. Wiendl, B. Kieseier, 2011, The Lancet Neurology.

Expert opinion on COVID-19 vaccination and the use of cladribine tablets in clinical practice

D. Centonze, P. Vermersch, P. Sørensen, 2021, medRxiv.

mice by inducing dysfunction of the cerebral microvasculature Regulatory T cells are strong promoters of acute ischemic stroke in

P. Jakob, H. Wiendl, A. Zernecke, 2013 .

The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans.

Lieping Chen, H. Wiendl, H. Salih, 2006, Experimental hematology.

Vitiligo after alemtuzumab treatment

W. Sondermann, H. Wiendl, A. Schulte-Mecklenbeck, 2018, Neurology.

Long-term efficacy of alemtuzumab in polymyositis

H. Wiendl, S. Meuth, T. Kuhlmann, 2014, Rheumatology.

Multiple sclerosis: Reprogramming the immune repertoire with alemtuzumab in MS

H. Wiendl, B. Kieseier, 2013, Nature Reviews Neurology.

Multiple sclerosis: reprogramming the immune repertoire with alemtuzumab in MS.

H. Wiendl, B. Kieseier, 2013, Nature reviews. Neurology.

Reply to “Investigating the Immunopathogenic Mechanisms Underlying MOGAD”

J. Lünemann, H. Wiendl, C. Gross, 2021, Annals of neurology.

Deterministic programming of human pluripotent stem cells into microglia facilitates studying their role in health and disease

H. Schöler, H. Wiendl, D. Schafflick, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Guidance for the management of myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS) during the COVID-19 pandemic

H. Wiendl, J. Vissing, R. Mantegazza, 2020, Journal of the Neurological Sciences.

α4-integrin receptor desaturation and disease activity return after natalizumab cessation

L. Kappos, T. Derfuss, H. Wiendl, 2017, Neurology: Neuroimmunology & Neuroinflammation.

Primary Angiitis of the CNS A Systematic Review and Meta-analysis

H. Wiendl, R. Rawal, S. Meuth, 2022 .

Intracerebral Dendritic Cells Critically Modulate Encephalitogenic versus Regulatory Immune Responses in the CNS

H. Wiendl, JangEun Lee, Z. Fabry, 2009, The Journal of Neuroscience.

Clinically relevant interaction of rivaroxaban and valproic acid – A case report

H. Wiendl, S. Meuth, R. Mesters, 2020, Seizure.

Ocrelizumab initiation in patients with MS

F. Zipp, H. Wiendl, S. Meuth, 2020, Neurology: Neuroimmunology & Neuroinflammation.

Intratumor heterogeneity and T cell exhaustion in primary CNS lymphoma

G. Lenz, W. Stummer, Marlon Stoeckius, 2022, Genome Medicine.

Targeting Different Monocyte/Macrophage Subsets Has No Impact on Outcome in Experimental Stroke

H. Wiendl, M. Mack, W. Schäbitz, 2017, Stroke.

Longitudinal analyses of serum neurofilament light and associations with obesity indices and bioelectrical impedance parameters

J. Wellmann, H. Wiendl, P. Benkert, 2022, Scientific Reports.

Fast track to becoming a regulatory T cell: “trogocytosis” of immune-tolerogenic HLA-G

H. Wiendl, 2007 .

Analysis of Lymphocyte Extravasation Using an In Vitro Model of the Human Blood-brain Barrier.

H. Wiendl, A. Schulte-Mecklenbeck, C. Gross, 2017, Journal of visualized experiments : JoVE.

Cerebrospinal fluid parameters of B cell-related activity in patients with active disease during natalizumab therapy

H. Wiendl, F. Weber, C. Geis, 2013, Multiple sclerosis.

Infectious risk stratification in multiple sclerosis patients receiving immunotherapy

H. Hartung, H. Wiendl, S. Meuth, 2017, Annals of clinical and translational neurology.

Efficacy and safety of alemtuzumab versus fingolimod in RRMS after natalizumab cessation

H. Wiendl, B. Tackenberg, S. Meuth, 2018, Journal of Neurology.

Immunotherapeutic approaches in MS: update on pathophysiology and emerging agents or strategies 2006.

H. Wiendl, S. Meuth, B. Kieseier, 2007, Endocrine, metabolic & immune disorders drug targets.

CNS Pericytes Modulate Local T Cell Infiltration in EAE

H. Wiendl, T. Kuhlmann, A. Zarbock, 2022, International journal of molecular sciences.

Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration.

H. Wiendl, A. Zarbock, D. Vestweber, 2017, Cell reports.

Immune cell profiling in the cerebrospinal fluid of patients with primary angiitis of the central nervous system reflects the heterogeneity of the disease

H. Wiendl, A. Schulte-Mecklenbeck, S. Meuth, 2018, Journal of Neuroimmunology.

Neurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration

L. Schöls, H. Wiendl, A. Schulte-Mecklenbeck, 2016, Neurology: Neuroimmunology & Neuroinflammation.

Analysis of the C/T(-1) single nucleotide polymorphism in the CD40 gene in multiple sclerosis.

H. Wiendl, P. Rieckmann, D. Buck, 2006, Tissue antigens.

Clinical outcomes in patients who discontinue natalizumab therapy after 2 years in the Tysabri® Observational Program (TOP)

L. Kappos, M. Trojano, H. Wiendl, 2020, Multiple sclerosis.

Therapy with natalizumab is associated with high JCV seroconversion and rising JCV index values

H. Wiendl, C. Gross, D. Brassat, 2016, Neurology: Neuroimmunology & Neuroinflammation.

NK Cell Patterns in Idiopathic Inflammatory Myopathies with Pulmonary Affection

H. Wiendl, S. Meuth, W. Stenzel, 2021, Cells.

Computed tomography–based quantification of lesion water uptake identifies patients within 4.5 hours of stroke onset: A multicenter observational study

W. Heindel, H. Wiendl, M. Knauth, 2016, Annals of neurology.

The trials and errors in MS therapy.

H. Wiendl, S. Meuth, C. Kleinschnitz, 2008, International MS journal.

Evidence of a pathogenic role for CD8+ T cells in anti-GABAB receptor limbic encephalitis

C. Elger, G. Widman, A. Becker, 2016, Neurology: Neuroimmunology & Neuroinflammation.

Neuron-directed autoimmunity in the central nervous system: entities, mechanisms, diagnostic clues, and therapeutic options.

H. Wiendl, S. Meuth, N. Melzer, 2012, Current opinion in neurology.

CD8+ T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing

G. Widman, A. Becker, H. Wiendl, 2016, Nature Communications.

Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation

R. Hohlfeld, H. Wiendl, T. Ziemssen, 2016, Proceedings of the National Academy of Sciences.

Alemtuzumab treatment alters circulating innate immune cells in multiple sclerosis

V. Arolt, J. Alferink, H. Wiendl, 2016, Neurology: Neuroimmunology & Neuroinflammation.

Natalizumab treatment in a patient with chronic inflammatory demyelinating polyneuropathy.

H. Hartung, Max-Philipp Stenner, H. Wiendl, 2010, Archives of neurology.

Impact of FcγR variants on the response to alemtuzumab in multiple sclerosis

J. Lünemann, H. Wiendl, S. Meuth, 2019, Annals of clinical and translational neurology.

Comparison of switching to 6-week dosing of natalizumab versus continuing with 4-week dosing in patients with relapsing-remitting multiple sclerosis (NOVA): a randomised, controlled, open-label, phase 3b trial

Jeffrey A. Cohen, Islam M. Zaydan, Gregory F. Wu, 2022, The Lancet Neurology.

Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis

H. Wiendl, S. Meuth, T. Budde, 2022, Journal of Neuroinflammation.

The genetic influence of the nonclassical MHC molecule HLA-G on multiple sclerosis.

H. Wiendl, A. Kroner, M. Mäurer, 2007, Human immunology.

Ineffective treatment of PML with pembrolizumab

H. Wiendl, S. Meuth, M. Pawlitzki, 2019, Neurology: Neuroimmunology & Neuroinflammation.

No evidence for loss of natalizumab effectiveness with every-6-week dosing: a propensity score–matched comparison with every-4-week dosing in patients enrolled in the Tysabri Observational Program (TOP)

L. Kappos, M. Trojano, H. Wiendl, 2021, Therapeutic advances in neurological disorders.

Skeletal muscle provides the immunological micro-milieu for specific plasma cells in anti-synthetase syndrome-associated myositis

J. Lünemann, H. Wiendl, S. Meuth, 2022, Acta Neuropathologica.

Human herpesvirus 6 in serum and spinal fluid of patients with multiple sclerosis?

H. Wiendl, F. Neipel, G. Jahn, 2003, Archives of neurology.

Rivaroxaban ameliorates disease course in an animal model of multiple sclerosis

H. Wiendl, S. Meuth, C. Kleinschnitz, 2017, Journal of Neuroimmunology.

Destruction of neurons by cytotoxic T cells: A new pathogenic mechanism in rasmussen's encephalitis

C. Elger, J. Schramm, H. Lassmann, 2002, Annals of neurology.

Autoimmunity and long-term safety and efficacy of alemtuzumab for multiple sclerosis: Benefit/risk following review of trial and post-marketing data

X. Montalban, P. Vermersch, A. Traboulsee, 2021, Multiple sclerosis.

Nucleotide metabolizing ectoenzymes are upregulated in A431 cells periodically treated with cytostatic ATP leading to partial resistance without preventing apoptosis.

H. Wiendl, C. Schneider, A. Ogilvie, 1998, Biochimica et biophysica acta.

Chances and Challenges of Registry-Based Pharmacovigilance in Multiple Sclerosis: Lessons Learnt from the Implementation of the Multicenter REGIMS Registry

F. Paul, P. Schwenkreis, F. Zipp, 2020, Drug Safety.

Onconeural antigen spreading in paraneoplastic neurological disease due to small cell lung cancer

H. Wiendl, A. Schulte-Mecklenbeck, S. Meuth, 2018, Oxford medical case reports.

Treating refractory post-herpetic anti-N-methyl-d-aspartate receptor encephalitis with rituximab

H. Wiendl, A. Schulte-Mecklenbeck, S. Meuth, 2017, Oxford medical case reports.

Neurocognitive decline in HIV patients is associated with ongoing T-cell activation in the cerebrospinal fluid

H. Wiendl, A. Schulte-Mecklenbeck, S. Meuth, 2015, Annals of clinical and translational neurology.

Safety experience with continued exposure to ofatumumab in patients with relapsing forms of multiple sclerosis for up to 3.5 years

L. Kappos, A. Cross, H. Wiendl, 2022, Multiple sclerosis.

Integrated single-cell transcriptomics of cerebrospinal fluid cells in treatment-naïve multiple sclerosis

Kejie Li, H. Wiendl, M. Heming, 2022, Journal of neuroinflammation.

Progressive multifocal leukoencephalopathy genetic risk variants for pharmacovigilance of immunosuppressant therapies

E. Hatchwell, E. Major, H. Wiendl, 2022, Frontiers in Neurology.

Impaired B Cell Expression of the Inhibitory Fcγ Receptor IIB in Myasthenia Gravis

J. Lünemann, H. Wiendl, C. Gross, 2022, Annals of neurology.

From the Background to the Spotlight: TASK Channels in Pathological Conditions

H. Wiendl, S. Meuth, T. Budde, 2010, Brain pathology.

Review and meta-analysis of neuropsychological findings in autoimmune limbic encephalitis with autoantibodies against LGI1, CASPR2, and GAD65 and their response to immunotherapy

D. Perani, T. Bartsch, H. Wiendl, 2022, Clinical Neurology and Neurosurgery.

MMF induces antioxidative and anaplerotic pathways and is neuroprotective in hyperexcitability in vitro.

H. Wiendl, S. Meuth, T. Budde, 2022, Free radical biology & medicine.

Pegyliertes Interferon-beta 1a

H. Wiendl, B. Tackenberg, B. Kieseier, 2015, Der Nervenarzt.

Acute and chronic structural effects of pilocarpine on monkey outflow tissues.

P. Kaufman, H. Wiendl, E. Lütjen-Drecoll, 1998, Transactions of the American Ophthalmological Society.

MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD

H. Schöler, H. Wiendl, S. Meuth, 2022, Redox biology.

The Coagulation Factors Fibrinogen, Thrombin, and Factor XII in Inflammatory Disorders—A Systematic Review

H. Wiendl, S. Meuth, C. Kleinschnitz, 2018, Front. Immunol..

Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects

A. Bar-Or, H. Wiendl, A. Schulte-Mecklenbeck, 2019, Science Translational Medicine.

An Imbalance of Two Functionally and Phenotypically Different Subsets of Plasmacytoid Dendritic Cells Characterizes the Dysfunctional Immune Regulation in Multiple Sclerosis

H. Wiendl, K. Toyka, B. Kieseier, 2010, The Journal of Immunology.

The Agony of Choice? Preserved Affective Decision Making in Early Multiple Sclerosis

H. Wiendl, S. Meuth, A. Johnen, 2020, Frontiers in Neurology.

Resolving the cognitive clinico-radiological paradox – Microstructural degeneration of fronto-striatal-thalamic loops in early active multiple sclerosis

H. Wiendl, S. Meuth, A. Johnen, 2019, Cortex.

Pharmacological Treatment of Early Multiple Sclerosis

A. Bar-Or, H. Hartung, R. Zivadinov, 2008, Drugs.

Can cognitive assessment really discriminate early stages of Alzheimer’s and behavioural variant frontotemporal dementia at initial clinical presentation?

H. Wiendl, H. Lohmann, A. Johnen, 2017, Alzheimer's Research & Therapy.

Dichoptic Metacontrast Masking Functions to Infer Transmission Delay in Optic Neuritis

Maximilian Bruchmann, Sven G. Meuth, Catharina Korsukewitz, 2016, PloS one.

Dementia Apraxia Test (DATE): A Brief Tool to Differentiate Behavioral Variant Frontotemporal Dementia from Alzheimer's Dementia Based on Apraxia Profiles.

H. Wiendl, H. Lohmann, A. Johnen, 2015, Journal of Alzheimer's disease : JAD.

Apraxia profile differentiates behavioural variant frontotemporal from Alzheimer's dementia in mild disease stages

H. Wiendl, H. Lohmann, A. Johnen, 2014, Journal of Neurology, Neurosurgery & Psychiatry.

An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction.

H. Wiendl, S. Meuth, H. Galla, 2016, Journal of visualized experiments : JoVE.

Paraneoplastic and non-paraneoplastic autoimmunity to neurons in the central nervous system

H. Wiendl, S. Meuth, N. Melzer, 2012, Journal of Neurology.

Factors associated with treatment escalation among MS specialists and general neurologists: Results from an International cojoint study.

X. Montalban, H. Wiendl, E. Havrdová, 2021, Multiple sclerosis and related disorders.

Dose-dependent melanonychia by mitoxantrone

H. Wiendl, S. Meuth, C. Reinsberger, 2009, Multiple sclerosis.

The risk of infections for multiple sclerosis and neuromyelitis optica spectrum disorder disease-modifying treatments: Eighth European Committee for Treatment and Research in Multiple Sclerosis Focused Workshop Review. April 2021

J. Casanova, M. Filippi, M. Sormani, 2022, Multiple sclerosis.

Myelin Oligodendrocyte Glycoprotein (MOG35-55) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice

H. Wiendl, S. Meuth, S. Bittner, 2014, Journal of visualized experiments : JoVE.

A novel NMDA receptor test model based on hiPSC-derived neural cells

H. Wiendl, S. Meuth, T. Budde, 2023, Biological chemistry.

Symptomatic therapy in multiple sclerosis: a review for a multimodal approach in clinical practice

H. Wiendl, L. Airas, H. Mattle, 2011, Therapeutic advances in neurological disorders.

Myalgia with the presence of pathologic EMG correlates with perimysial inflammatory infiltrates

C. Wessig, H. Wiendl, C. Sommer, 2019, Neurology: Neuroimmunology & Neuroinflammation.

Interferon-β enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis

M. Weller, H. Hartung, Lieping Chen, 2004, Journal of Neuroimmunology.

Case Report: A Spinal Ischemic Lesion in a 24-Year-Old Patient With Fabry Disease

H. Wiendl, S. Meuth, T. Duning, 2020, Frontiers in Immunology.

TRPM2 Cation Channels Modulate T Cell Effector Functions and Contribute to Autoimmune CNS Inflammation

Kerstin Göbel, Heinz Wiendl, H. Wiendl, 2012, PloS one.

FTY720 (fingolimod) treatment tips the balance towards less immunogenic antigen-presenting cells in patients with multiple sclerosis

F. Zipp, H. Wiendl, E. Witsch, 2015, Multiple sclerosis.

Glatiramer acetate attenuates pro-inflammatory T cell responses but does not directly protect neurons from inflammatory cell death.

Max-Philipp Stenner, H. Wiendl, S. Meuth, 2010, The American journal of pathology.

Multiple sclerosis therapeutics

Reinhard Hohlfeld, Heinz Wiendl, R. Hohlfeld, 2009, Neurology.

The role of regulatory T cells in multiple sclerosis

Heinz Wiendl, H. Wiendl, Alla L Zozulya, 2008, Nature Clinical Practice Neurology.

Multiple sclerosis: comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells.

C. Farina, R. Hohlfeld, H. Wiendl, 2000, Proceedings of the National Academy of Sciences of the United States of America.

WHO grade associated downregulation of MHC class I antigen-processing machinery components in human astrocytomas: does it reflect a potential immune escape mechanism?

M. Weller, H. Wiendl, M. Mehling, 2007, Acta Neuropathologica.

Generating microglia from human pluripotent stem cells: novel in vitro models for the study of neurodegeneration

H. Wiendl, S. Meuth, Anna M Speicher, 2019, Molecular Neurodegeneration.

Defective synaptic transmission causes disease signs in a mouse model of juvenile neuronal ceroid lipofuscinosis

H. Pape, H. Wiendl, C. Geis, 2017, eLife.

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Sonja W. Scholz, W. M. van der Flier, Till F. M. Andlauer, 2019, Acta Neuropathologica.

Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation

Christian Gieger, Bernhard Hemmer, Mark Mühlau, 2016, Science Advances.

Complete Epstein-Barr virus seropositivity in a large cohort of patients with early multiple sclerosis

F. Paul, B. Hemmer, H. Wiendl, 2020, Journal of Neurology, Neurosurgery, and Psychiatry.

Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis

N. Yosef, Michael Cole, H. Wiendl, 2018, Nature Communications.

Tolerogenic dendritic cell-based treatment for multiple sclerosis (MS): a harmonised study protocol for two phase I clinical trials comparing intradermal and intranodal cell administration

P. Parizel, F. Prósper, W. van Hecke, 2019, BMJ Open.

Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges

H. Wiendl, D. Schafflick, Maike Hartlehnert, 2021, Nature Neuroscience.

Redefining the heterogeneity of peripheral nerve cells in health and autoimmunity

H. Wiendl, Jolien Wolbert, M. Heming, 2020, Proceedings of the National Academy of Sciences.

Specific Patterns of Immune Cell Dynamics May Explain the Early Onset and Prolonged Efficacy of Cladribine Tablets

F. Barkhof, X. Montalban, P. Vermersch, 2022, Neurology: Neuroimmunology & Neuroinflammation.

Combined Neurofilament Light and Optical Coherence Tomography Better Predicts Multiple Sclerosis Disease Activity Than Either Measure Alone

H. Wiendl, S. Meuth, P. Albrecht, 2021, Neurology: Neuroimmunology & Neuroinflammation.

Multiple Sclerosis Therapy Consensus Group (MSTCG): position statement on disease-modifying therapies for multiple sclerosis (white paper)

J. Lünemann, A. Gass, C. Enzinger, 2021, Therapeutic advances in neurological disorders.

Immune reconstitution therapies: concepts for durable remission in multiple sclerosis

J. Lünemann, A. Bar-Or, H. Wiendl, 2019, Nature Reviews Neurology.

Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus

H. Wiendl, T. Kuhlmann, T. Korn, 2018, Journal of neuroinflammation.

ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis

David H. Miller, A. Thompson, M. Sormani, 2018, Multiple sclerosis.

The quality of cortical network function recovery depends on localization and degree of axonal demyelination

H. Pape, H. Wiendl, S. Meuth, 2017, Brain, Behavior, and Immunity.

ALAIN01—Alemtuzumab in autoimmune inflammatory neurodegeneration: mechanisms of action and neuroprotective potential

H. Wiendl, S. Meuth, C. Gross, 2016, BMC Neurology.

A novel automated segmentation method for retinal layers in OCT images proves retinal degeneration after optic neuritis

A. Droby, F. Zipp, H. Wiendl, 2015, British Journal of Ophthalmology.

Safety and Clinical Outcomes of Rituximab Treatment in Patients with Multiple Sclerosis and Neuromyelitis Optica: Experience from a National Online Registry (GRAID)

F. Paul, U. Ziemann, H. Wiendl, 2015, Journal of Neuroimmune Pharmacology.

Teriflunomide and Its Mechanism of Action in Multiple Sclerosis

A. Bar-Or, H. Wiendl, J. Kaplan, 2014, Drugs.

CD4+NKG2D+ T Cells Exhibit Enhanced Migratory and Encephalitogenic Properties in Neuroinflammation

H. Wiendl, S. Meuth, T. Kuhlmann, 2013, PloS one.

Modulation of IL-2Rα with daclizumab for treatment of multiple sclerosis

H. Wiendl, C. Gross, 2013, Nature Reviews Neurology.

Anti-JC virus antibodies in a large German natalizumab-treated multiple sclerosis cohort

H. Wiendl, R. Gold, C. Hemmelmann, 2012, Neurology.

Janus head: the dual role of HLA-G in CNS immunity

H. Wiendl, L. Airas, N. Schwab, 2011, Cellular and Molecular Life Sciences.

Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis

A. Mildner, U. Bogdahn, M. Neurath, 2010, Brain : a journal of neurology.

Specific central nervous system recruitment of HLA‐G+ regulatory T cells in multiple sclerosis

W. Brück, H. Wiendl, K. Toyka, 2009, Annals of neurology.

Immunotherapy of multiple sclerosis

H. Wiendl, S. Meuth, S. Bittner, 2009, Acta Neuropsychiatrica.

Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity.

M. Weller, A. Bar-Or, H. Wiendl, 2005, Brain : a journal of neurology.

A PD‐1 polymorphism is associated with disease progression in multiple sclerosis

B. Hemmer, H. Wiendl, M. Mehling, 2005, Annals of neurology.

Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study

D. Conen, K. Blennow, C. Granziera, 2022, The Lancet Neurology.

Humoral signatures of MOG-antibody-associated disease track with age and disease activity

D. Lauffenburger, J. Lünemann, E. Meinl, 2023, Cell reports. Medicine.

Successful Replication of GWAS Hits for Multiple Sclerosis in 10,000 Germans Using the Exome Array

M. Waldenberger, K. Strauch, A. Ziegler, 2015, Genetic epidemiology.

Reduced cortisol levels in cerebrospinal fluid and differential distribution of 11β-hydroxysteroid dehydrogenases in multiple sclerosis: Implications for lesion pathogenesis

H. Wiendl, M. Buttmann, M. Mehling, 2010, Brain, Behavior, and Immunity.

Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis.

M. Weller, Lieping Chen, H. Wiendl, 2003, Cancer research.

Dietary salt promotes ischemic brain injury and is associated with parenchymal migrasome formation

C. Sommer, H. Wiendl, J. Minnerup, 2018, PloS one.

Cerebrospinal fluid flow cytometry distinguishes psychosis spectrum disorders from differential diagnoses

V. Arolt, U. Dannlowski, B. Baune, 2021, Molecular Psychiatry.

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells

C. Ruppert, H. Wiendl, S. Meuth, 2016, Nature Communications.

Regulatory T cells exhibit enhanced migratory characteristics, a feature impaired in patients with multiple sclerosis

Max-Philipp Stenner, H. Wiendl, N. Schwab, 2010, European journal of immunology.

Gut–CNS-Axis as Possibility to Modulate Inflammatory Disease Activity—Implications for Multiple Sclerosis

D. Schuppan, H. Wiendl, L. Klotz, 2017, International journal of molecular sciences.

Intraocular dendritic cells characterize HLA-B27-associated acute anterior uveitis

A. Heiligenhaus, H. Wiendl, D. Schafflick, 2021, eLife.

Bcl6 controls meningeal Th17–B cell interaction in murine neuroinflammation

Gregory F. Wu, H. Wiendl, D. Schafflick, 2021, Proceedings of the National Academy of Sciences.

Serial position effects rapidly distinguish Alzheimer’s from frontotemporal dementia

Nadine Kloth, H. Wiendl, S. Meuth, 2019, Journal of Neurology.

Discriminative power of intra-retinal layers in early multiple sclerosis using 3D OCT imaging

V. Fleischer, A. Droby, F. Zipp, 2018, Journal of Neurology.

CD8+ T cells and neuronal damage: direct and collateral mechanisms of cytotoxicity and impaired electrical excitability

H. Wiendl, S. Meuth, N. Melzer, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Why Most Acute Stroke Studies Are Positive in Animals but Not in Patients: A Systematic Comparison of Preclinical, Early Phase, and Phase 3 Clinical Trials of Neuroprotective Agents

J. Wellmann, H. Wiendl, S. Meuth, 2019, Annals of neurology.

Neuroimmunotherapies Targeting T Cells: From Pathophysiology to Therapeutic Applications

H. Wiendl, S. Bittner, 2015, Neurotherapeutics.

Immunobiology of muscle: advances in understanding an immunological microenvironment.

Reinhard Hohlfeld, Heinz Wiendl, R. Hohlfeld, 2005, Trends in immunology.

Structured Delirium Management in the Hospital-a Randomized Controlled Trial.

Thomas A. Hooven, H. Wiendl, T. Duning, 2022, Deutsches Arzteblatt international.

Biphasic cytotoxic mechanism of extracellular ATP on U-937 human histiocytic leukemia cells: involvement of adenosine generation.

H. Wiendl, C. Schneider, A. Ogilvie, 2001, Biochimica et biophysica acta.

Effects of Blood Transportation on Human Peripheral Mononuclear Cell Yield, Phenotype and Function: Implications for Immune Cell Biobanking

A. Bar-Or, H. Wiendl, S. Meuth, 2014, PloS one.

Interferon-Beta Therapy of Multiple Sclerosis Patients Improves the Responsiveness of T Cells for Immune Suppression by Regulatory T Cells

H. Wiendl, C. Gross, F. Luessi, 2015, International journal of molecular sciences.

Immune Cell Activation in the Cerebrospinal Fluid of Patients With Parkinson's Disease

H. Wiendl, S. Meuth, C. Gross, 2018, Front. Neurol..

Acute Disseminated Encephalomyelitis An Update

H. Hartung, B. Hemmer, H. Wiendl, 2005 .

[Cerebral and spinal MRI examination in patients with clinically isolated syndrome and definite multiple sclerosis].

A. Gass, L. Kappos, F. Fazekas, 2008, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

Nrf2 and beyond: deciphering the mode of action of fumarates in the inflamed central nervous system

H. Wiendl, B. Kieseier, 2015, Acta Neuropathologica.

Immune Cell Profiling of the Cerebrospinal Fluid Provides Pathogenetic Insights Into Inflammatory Neuropathies

H. Wiendl, A. Schulte-Mecklenbeck, Jolien Wolbert, 2019, Front. Immunol..

COVID-19-associated risks and effects in myasthenia gravis (CARE-MG)

H. Wiendl, M. Maas, J. Vissing, 2020, The Lancet Neurology.

Lack of evidence for a pathogenic role of T-lymphocytes in an animal model for Charcot-Marie-Tooth disease 1A

C. Wessig, H. Wiendl, R. Martini, 2010, Neurobiology of Disease.

The co-inhibitory molecule PD-1 modulates disease severity in a model for an inherited, demyelinating neuropathy

C. Wessig, H. Wiendl, C. Sommer, 2009, Neurobiology of Disease.

MCAM/CD146 Signaling via PLCγ1 Leads to Activation of β1-Integrins in Memory T-Cells Resulting in Increased Brain Infiltration

H. Wiendl, A. Zarbock, N. Schwab, 2020, Frontiers in Immunology.

Modulation of T-effector function by imatinib at the level of cytokine secretion.

H. Einsele, H. Wiendl, C. Leder, 2007, Experimental hematology.

IL-17 Silencing Does Not Protect Nonobese Diabetic Mice from Autoimmune Diabetes

H. Wiendl, Fabian M. P. Kaiser, Julie Joseph, 2012, The Journal of Immunology.

Cerebrospinal fluid proteomics indicates immune dysregulation and neuronal dysfunction in antibody associated autoimmune encephalitis.

I. Amit, F. Rosenow, D. Esser, 2023, Journal of autoimmunity.

Immune-refractory cancers and their little helpers--an extended role for immunetolerogenic MHC molecules HLA-G and HLA-E?

H. Wiendl, J. Wischhusen, A. Waschbisch, 2007, Seminars in cancer biology.

Detrimental Contribution of the Immuno-Inhibitor B7-H1 to Rabies Virus Encephalitis1

Lieping Chen, H. Wiendl, R. Flavell, 2008, The Journal of Immunology.

Leukocyte profiles in blood and CSF distinguish neurosarcoidosis from multiple sclerosis

H. Wiendl, A. Schulte-Mecklenbeck, M. Heming, 2020, Journal of Neuroimmunology.

Dysphagia in NMOSD and MOGAD as a surrogate of brain involvement?

H. Wiendl, S. Meuth, T. Warnecke, 2020, European journal of neurology.

Ofatumumab versus Teriflunomide in Multiple Sclerosis.

Jeffrey A. Cohen, X. Montalban, L. Kappos, 2020, The New England journal of medicine.

Detecting myositis as a cause of unexplained dysphagia: Proposal for a diagnostic algorithm

C. Rudack, H. Wiendl, A. Beule, 2021, European journal of neurology.

CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery.

A. Becker, H. Wiendl, C. Bien, 2009, Brain : a journal of neurology.

An Assay to Determine Mechanisms of Rapid Autoantibody-Induced Neurotransmitter Receptor Endocytosis and Vesicular Trafficking in Autoimmune Encephalitis

H. Hartung, H. Wiendl, S. Meuth, 2019, Front. Neurol..

Immunophenotyping of cerebrospinal fluid cells in multiple sclerosis: in search of biomarkers.

H. Wiendl, O. Stüve, M. Stangel, 2014, JAMA neurology.

The neuroinflammation biobank in the Department of Neurology, University Hospital Muenster, Germany.

H. Wiendl, Anita Posevitz-Fejfár, 2014, Biopreservation and biobanking.

Stroke induces disease-specific myeloid cells in the brain parenchyma and pia

H. Wiendl, D. Schafflick, Jolien Wolbert, 2022, Nature Communications.

Stroke induces disease-specific myeloid cells in the brain parenchyma and pia

H. Wiendl, D. Schafflick, Jolien Wolbert, 2022, Nature communications.

Review and meta-analysis of neuropsychological findings in autoimmune limbic encephalitis with autoantibodies against LGI1, CASPR2, and GAD65 and their response to immunotherapy

D. Perani, T. Bartsch, H. Wiendl, 2022, Clinical Neurology and Neurosurgery.

A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies

C. Elger, W. Lieb, J. Wellmer, 2022, Brain : a journal of neurology.

An Autoreactive γδ TCR Derived from a Polymyositis Lesion1

R. Hohlfeld, H. Wiendl, H. Wekerle, 2002, The Journal of Immunology.

Ion channels in autoimmune neurodegeneration

H. Wiendl, S. Meuth, T. Budde, 2011, FEBS letters.

Smad 7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis

A. Mildner, U. Bogdahn, M. Neurath, 2010 .

Collateral neuronal apoptosis in CNS gray matter during an oligodendrocyte‐directed CD8+ T cell attack

H. Wiendl, S. Meuth, S. Bittner, 2009, Glia.

M. Weller, H. Hartung, H. Wiendl, 2003, Journal of Neuroimmunology.

Cytotoxic CD8+ T Cell–Neuron Interactions: Perforin-Dependent Electrical Silencing Precedes But Is Not Causally Linked to Neuronal Cell Death

S. Hallermann, F. Zipp, H. Wiendl, 2009, The Journal of Neuroscience.

Alemtuzumab in Multiple Sclerosis: Mechanism of Action and Beyond

H. Wiendl, S. Meuth, T. Ruck, 2015, International journal of molecular sciences.

Expiratory Muscle Strength Training for Therapy of Pharyngeal Dysphagia in Parkinson's Disease

H. Wiendl, T. Warnecke, B. Labeit, 2021, Movement disorders : official journal of the Movement Disorder Society.

Primary Angiitis of the CNS

H. Wiendl, R. Rawal, S. Meuth, 2021, Neurology: Neuroimmunology & Neuroinflammation.

Defining the architecture of cerebrospinal fluid cellular communities in neuroinflammatory diseases

D. Malhotra, V. Menon, P. D. De Jager, 2021 .

Nur77 serves as a molecular brake of the metabolic switch during T cell activation to restrict autoimmunity

H. Wiendl, T. Kuhlmann, M. Beyer, 2018, Proceedings of the National Academy of Sciences.

Review of Novel Immunotherapeutic Strategies for MS

R. Hohlfeld, H. Wiendl, 2007 .

Monocyte-derived HLA-G acts as a strong inhibitor of autologous CD4 T cell activation and is upregulated by interferon-β in vitro and in vivo: rationale for the therapy of multiple sclerosis

J. Dichgans, M. Weller, H. Hartung, 2005, Journal of Neuroimmunology.

Disease-modifying therapies in multiple sclerosis: an update on recent and ongoing trials and future strategies

H. Wiendl, B. Kieseier, 2003, Expert opinion on investigational drugs.

Expression of the B 7-Related Molecule B 7-H 1 by Glioma Cells : A Potential Mechanism of Immune Paralysis 1

M. Weller, Lieping Chen, H. Wiendl, 2003 .

Cells : A Potential Mechanism of Immune Paralysis Expression of the B 7-Related Molecule B 7-H 1 by Glioma Updated

M. Weller, Lieping Chen, H. Wiendl, 2003 .

High-Dimensional Cytometry Dissects Immunological Fingerprints of Idiopathic Inflammatory Myopathies

H. Wiendl, S. Meuth, W. Stenzel, 2022, Cells.

Treatment and treatment trials in multiple sclerosis

Bernhard Hemmer, Hans-Peter Hartung, Heinz Wiendl, 2007, Current opinion in neurology.

Does the environment influence multiple sclerosis pathogenesis via UVB light and/or induction of vitamin D?

H. Wiendl, K. Loser, N. Mykicki, 2019, Journal of Neuroimmunology.

Evaluation of Age-Dependent Immune Signatures in Patients With Multiple Sclerosis

H. Wiendl, A. Schulte-Mecklenbeck, S. Meuth, 2021, Neurology: Neuroimmunology & Neuroinflammation.

Cytosolic RIG-I–like helicases act as negative regulators of sterile inflammation in the CNS

S. Akira, K. Knobeloch, G. Hartmann, 2011, Nature Neuroscience.

Dimethyl fumarate treatment restrains the antioxidative capacity of T cells to control autoimmunity

F. Zipp, T. Derfuss, H. Wiendl, 2021, Brain : a journal of neurology.

Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk

H. Ullum, T. Werge, H. Hakonarson, 2018, Cell.

HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation.

H. Wiendl, T. Biedermann, A. Melms, 2007, Blood.

Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3

H. Lähdesmäki, G. Silberberg, J. Tegnér, 2018, BMC Biology.

Animal models in idiopathic inflammatory myopathies: How to overcome a translational roadblock?

H. Wiendl, S. Meuth, T. Ruck, 2017, Autoimmunity reviews.

A β-Lactam Antibiotic Dampens Excitotoxic Inflammatory CNS Damage in a Mouse Model of Multiple Sclerosis

Sven G. Meuth, Christoph Fahlke, Heinz Wiendl, 2008, PloS one.

A b-Lactam Antibiotic Dampens Excitotoxic Inflammatory CNS Damage in a Mouse Model of Multiple Sclerosis

H. Wiendl, S. Meuth, C. Fahlke, 2008 .

GluR3 antibodies: Prevalence in focal epilepsy but no specificity for Rasmussen’s encephalitis

J. Dichgans, C. Elger, H. Wiendl, 2001, Neurology.

An enigmatic case of cortical anopsia: Antemortem diagnosis of a 14-3-3 negative Heidenhain-variant MM1-sCJD

H. Wiendl, S. Meuth, O. Grauer, 2019, Prion.

Intravenous methadone causes acute toxic and delayed inflammatory encephalopathy with persistent neurocognitive impairments

H. Wiendl, A. Schulte-Mecklenbeck, A. Johnen, 2021, BMC Neurology.

Therapeutic Advances in Neurological Disorders

H. Wiendl, S. Meuth, T. Ruck, 2016 .

Monoclonal antibodies in neuroinflammatory diseases

H. Wiendl, L. Klotz, 2013, Expert opinion on biological therapy.

Patients with a relapsing course of SREAT exhibit persistent intrathecal CD4+ T cell activation.

H. Wiendl, S. Meuth, M. Pawlitzki, 2020, European journal of neurology.

The Innate Immune Response Characterizes Posterior Reversible Encephalopathy Syndrome

H. Wiendl, A. Schulte-Mecklenbeck, S. Meuth, 2021, Journal of Clinical Immunology.

Blockade of inhibitory killer cell immunoglobulin-like receptors and IL-2 triggering reverses the functional hypoactivity of tumor-derived NK-cells in glioblastomas

W. Stummer, H. Wiendl, A. Schulte-Mecklenbeck, 2022, Scientific Reports.

Liver X receptor activation promotes differentiation of regulatory T cells

H. Wiendl, P. Knolle, L. Klotz, 2017, PloS one.

Does an artistic representation of brand logos increase their effect on customers?

H. Wiendl, S. Meuth, A. Johnen, 2021, bioRxiv.

Amyotrophic lateral sclerosis patients show increased peripheral and intrathecal T-cell activation

M. Herty, H. Wiendl, A. Schulte-Mecklenbeck, 2021, Brain communications.

Advances in pathogenic concepts and therapeutic agents in Rasmussen’s encephalitis

C. Elger, H. Wiendl, C. Bien, 2002, Expert opinion on investigational drugs.

Sodium chloride promotes pro-inflammatory macrophage polarization thereby aggravating CNS autoimmunity.

H. Wiendl, S. Meuth, T. Kuhlmann, 2016, Journal of autoimmunity.

Fundamental mechanistic insights from rare but paradigmatic neuroimmunological diseases

H. Wiendl, C. Gross, R. Liblau, 2021, Nature Reviews Neurology.

March 2003: a 41 -year-old female with a solitary lesion in the liver.

J. Dichgans, M. Weller, H. Wiendl, 2003, Brain pathology.

Intercellular exchanges of membrane fragments (trogocytosis) between human muscle cells and immune cells: A potential mechanism for the modulation of muscular immune responses

H. Wiendl, S. Meuth, Hanns Lochmüller, 2009, Journal of Neuroimmunology.

Evidence of polygenic regulation of the physiological presence of neurofilament light chain in human serum

H. Wiendl, P. Benkert, E. Hofer, 2023, Frontiers in Neurology.

Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking.

H. Wiendl, S. Meuth, G. Stoll, 2011, Journal of autoimmunity.

Lessons from the Past and Future Approaches for Immunologic Therapies in Multiple Sclerosis

H. Wiendl, S. Meuth, C. Kleinschnitz, 2010 .

Eculizumab versus rituximab in generalised myasthenia gravis

H. Hartung, H. Wiendl, S. Meuth, 2022, Journal of Neurology, Neurosurgery, and Psychiatry.

What Have Failed, Interrupted, and Withdrawn Antibody Therapies in Multiple Sclerosis Taught Us?

H. Wiendl, J. Krämer, 2022, Neurotherapeutics.

An assay to quantify species-specific anti-JC virus antibody levels in MS patients

H. Hartung, H. Wiendl, M. Pawlita, 2013, Multiple sclerosis.

The two‐pore domain K2P channel TASK2 drives human NK‐cell proliferation and cytolytic function

H. Wiendl, A. Schulte-Mecklenbeck, S. Meuth, 2015, European journal of immunology.

Pathology of immune reconstitution inflammatory syndrome in multiple sclerosis with natalizumab-associated progressive multifocal leukoencephalopathy

M. Sahraian, E. Radue, W. Brück, 2011, Acta Neuropathologica.

Action of treosulfan in myelin-oligodendrocyte-glycoprotein-induced experimental autoimmune encephalomyelitis and human lymphocytes

M. Weller, H. Wiendl, Robert Weissert, 2003, Journal of Neuroimmunology.

Efficacy and Safety of Proposed Biosimilar Natalizumab (PB006) in Patients With Relapsing-Remitting Multiple Sclerosis

B. Hemmer, H. Wiendl, K. Selmaj, 2023, JAMA neurology.

Sex bias in MHC I-associated shaping of the adaptive immune system

Dennis Görlich, Satu Mustjoki, Heinz Wiendl, 2018, Proceedings of the National Academy of Sciences.

Hyponatremia upon presentation to the emergency department – the need for urgent neuroimaging studies

W. Schwindt, H. Wiendl, H. Pavenstädt, 2017, Scientific Reports.

Immunoregulatory factors in multiple sclerosis patients during and after pregnancy: relevance of natural killer cells

H. Wiendl, I. Elovaara, L. Airas, 2007, Clinical and experimental immunology.

Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS

H. Pape, H. Wiendl, S. Meuth, 2013, Nature Medicine.

Two pore domain potassium channels in cerebral ischemia: a focus on K2P9.1 (TASK3, KCNK9)

H. Wiendl, S. Meuth, T. Budde, 2010, Experimental & Translational Stroke Medicine.

Autoimmunity complicating SARS-CoV-2 infection in selective IgA-deficiency

H. Wiendl, S. Meuth, R. Dziewas, 2020, Neurology: Neuroimmunology & Neuroinflammation.

Acute bilateral optic/chiasm neuritis with longitudinal extensive transverse myelitis in longstanding stable multiple sclerosis following vector-based vaccination against the SARS-CoV-2

H. Wiendl, T. Boppel, C. Helmchen, 2021, Journal of Neurology.

The STING-IFN-β-Dependent Axis Is Markedly Low in Patients with Relapsing-Remitting Multiple Sclerosis

H. Wiendl, S. Meuth, T. Budde, 2020, International journal of molecular sciences.

Failed, Interrupted, or Inconclusive Trials on Immunomodulatory Treatment Strategies in Multiple Sclerosis: Update 2015–2020

H. Wiendl, S. Meuth, M. Pawlitzki, 2020, BioDrugs.

14‐3‐3 Proteins regulate K2P5.1 surface expression on T lymphocytes

H. Wiendl, S. Meuth, T. Budde, 2017, Traffic.

Efficacy and safety of natalizumab in multiple sclerosis: interim observational programme results

L. Kappos, M. Trojano, H. Wiendl, 2014, Journal of Neurology, Neurosurgery & Psychiatry.

TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system.

D. Bayliss, H. Wiendl, S. Meuth, 2009, Brain : a journal of neurology.

The impact of lesion location on dysphagia incidence, pattern and complications in acute stroke. Part 1: dysphagia incidence, severity and aspiration

W. Heindel, H. Wiendl, T. Warnecke, 2015, European journal of neurology.

Alemtuzumab Improves Cognitive Processing Speed in Active Multiple Sclerosis—A Longitudinal Observational Study

H. Wiendl, S. Meuth, H. Lohmann, 2018, Front. Neurol..

Identification of targets and new developments in the treatment of multiple sclerosis – focus on cladribine

H. Hartung, H. Wiendl, B. Kieseier, 2010, Drug design, development and therapy.

Regulatory Functions of Natural Killer Cells in Multiple Sclerosis

H. Wiendl, A. Schulte-Mecklenbeck, C. Gross, 2016, Front. Immunol..

Apraxia profiles—A single cognitive marker to discriminate all variants of frontotemporal lobar degeneration and Alzheimer's disease

H. Wiendl, S. Meuth, A. Johnen, 2018, Alzheimer's & dementia.

Expression and role of novel B7 family members in human muscle: implications for the pathogenesis of inflammatory myopathies

M. Weller, R. Hohlfeld, H. Wiendl, 2004 .

Dietary conjugated linoleic acid links reduced intestinal inflammation to amelioration of CNS autoimmunity

D. Schuppan, P. Rosenstiel, H. Wiendl, 2021, Brain : a journal of neurology.

Detecting myasthenia gravis as a cause of unclear dysphagia with an endoscopic tensilon test

H. Wiendl, S. Meuth, T. Warnecke, 2021, Therapeutic advances in neurological disorders.

Implications of dietary salt intake for multiple sclerosis pathogenesis

H. Wiendl, L. Klotz, Stephanie Hucke, 2016, Multiple sclerosis.

The future of multiple sclerosis therapy.

H. Hartung, H. Wiendl, B. Kieseier, 2009, Pharmacological research.

Oral Disease-Modifying Treatments for Multiple Sclerosis

H. Wiendl, B. Kieseier, 2007, CNS drugs.

CD4+ CD25+ FoxP3+ regulatory T cells suppress cytotoxicity of CD8+ effector T cells: implications for their capacity to limit inflammatory central nervous system damage at the parenchymal level

H. Wiendl, S. Meuth, S. Bittner, 2012, Journal of Neuroinflammation.

Basic and escalating immunomodulatory treatments in multiple sclerosis: Current therapeutic recommendations

P. Rieckmann, K. V. Toyka, H. Hartung, 2008, Journal of Neurology.

The impact of lesion location on dysphagia incidence, pattern and complications in acute stroke. Part 2: Oropharyngeal residue, swallow and cough response, and pneumonia

W. Heindel, H. Wiendl, T. Warnecke, 2017, European journal of neurology.

Temporal Pattern of ICAM-I Mediated Regulatory T Cell Recruitment to Sites of Inflammation in Adoptive Transfer Model of Multiple Sclerosis

H. Wiendl, S. Meuth, M. Reinhardt, 2010, PloS one.

Clinical relevance of specific T-cell activation in the blood and cerebrospinal fluid of patients with mild Alzheimer's disease

Michael Deppe, Sven G. Meuth, Hubertus Lohmann, 2015, Neurobiology of Aging.

Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis.

H. Rammensee, M. Missler, W. Stummer, 2019, Brain : a journal of neurology.

Distinct cognitive impairments in different disease courses of multiple sclerosis—A systematic review and meta-analysis

H. Wiendl, S. Meuth, A. Johnen, 2017, Neuroscience & Biobehavioral Reviews.

A Novel PKD1 Mutation Associated With Autosomal Dominant Kidney Disease and Cerebral Cavernous Malformation

H. Wiendl, S. Meuth, O. Grauer, 2018, Front. Neurol..

Molecular biomarkers and cognitive impairment in multiple sclerosis: State of the field, limitations, and future direction – A systematic review and meta-analysis

H. Wiendl, S. Meuth, A. Johnen, 2023, Neuroscience & Biobehavioral Reviews.

Is APOE ε4 associated with cognitive performance in early MS?

F. Paul, C. Graetz, F. Zipp, 2020, Neurology: Neuroimmunology & Neuroinflammation.

Optimizing therapy early in multiple sclerosis: An evidence-based view.

M. Sormani, H. Wiendl, T. Ziemssen, 2015, Multiple sclerosis and related disorders.

Lymphocyte pharmacodynamics are not associated with autoimmunity or efficacy after alemtuzumab

B. Sharrack, G. Comi, H. Wiendl, 2019, Neurology: Neuroimmunology & Neuroinflammation.

Increased cortical curvature reflects white matter atrophy in individual patients with early multiple sclerosis

Frauke Zipp, Michael Deppe, Tobias Ruck, 2014, NeuroImage: Clinical.

HLA-G 2012 conference: the 15-year milestone update.

H. Wiendl, S. Ferrone, E. Carosella, 2013, Tissue antigens.

Bruton tyrosine kinase inhibitors for multiple sclerosis

A. Bar-Or, H. Wiendl, J. Krämer, 2023, Nature Reviews Neurology.

A single-cell analysis framework allows for characterization of CSF leukocytes and their tissue of origin in multiple sclerosis

Gregory F. Wu, P. D. De Jager, H. Wiendl, 2022, Science Translational Medicine.

Classification of neurological diseases using multi-dimensional CSF analysis

H. Wiendl, S. Baranzini, A. Schulte-Mecklenbeck, 2021, Brain : a journal of neurology.

Evaluation of soluble HLA-G as a biomarker for multiple sclerosis

L. Kappos, H. Wiendl, C. Pohl, 2011, Neurology.

Clinical effects of natalizumab on multiple sclerosis appear early in treatment course

L. Kappos, C. Polman, P. Vermersch, 2013, Journal of Neurology.

[Multiple sclerosis. Current review of failed and discontinued clinical trials of drug treatment].

L. Kappos, R. Hohlfeld, H. Wiendl, 2000, Der Nervenarzt.

Generating microglia from human pluripotent stem cells: novel in vitro models for the study of neurodegeneration

H. Wiendl, S. Meuth, Anna M Speicher, 2019, Molecular Neurodegeneration.

Supporting the differential diagnosis of connective tissue diseases with neurological involvement by blood and cerebrospinal fluid flow cytometry

H. Wiendl, A. Schulte-Mecklenbeck, M. Heming, 2023, Journal of Neuroinflammation.

Complement Activation Is a Prominent Feature of MOGAD

J. Lünemann, H. Wiendl, C. Gross, 2021, Annals of neurology.

Greater sensitivity to multiple sclerosis disability worsening and progression events using a roving versus a fixed reference value in a prospective cohort study

L. Kappos, M. Trojano, H. Wiendl, 2017, Multiple sclerosis.

Alemtuzumab treatment exemplifies discordant immune effects of blood and cerebrospinal fluid in multiple sclerosis

H. Wiendl, Tobias Lautwein, M. Heming, 2023, Journal of Neuroimmunology.

High anti-JCPyV serum titers coincide with high CSF cell counts in RRMS patients

F. Zipp, H. Wiendl, A. Schulte-Mecklenbeck, 2020, Multiple sclerosis.

Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients

H. Wiendl, A. Melms, E. Tolosa, 2007, Clinical and experimental immunology.

Failed, Interrupted, or Inconclusive Trials on Neuroprotective and Neuroregenerative Treatment Strategies in Multiple Sclerosis: Update 2015–2020

H. Wiendl, S. Meuth, M. Pawlitzki, 2021, Drugs.

Intrathecal Immunoglobulin M Synthesis is an Independent Biomarker for Higher Disease Activity and Severity in Multiple Sclerosis

D. Conen, C. Granziera, L. Kappos, 2021, Annals of neurology.

Association of Intrathecal Immunoglobulin G Synthesis With Disability Worsening in Multiple Sclerosis.

F. Paul, U. Ziemann, F. Zipp, 2019, JAMA neurology.

Dimethyl fumarate treatment alters circulating T helper cell subsets in multiple sclerosis

H. Wiendl, A. Schulte-Mecklenbeck, C. Gross, 2015, Neurology: Neuroimmunology & Neuroinflammation.

Nuclear Receptor Control of Myeloid Cell Responses - Implications for CNS Autoimmunity

H. Wiendl, P. Knolle, L. Klotz, 2013 .

Cytoplasmic translocation of Olig2 in adult glial progenitors marks the generation of reactive astrocytes following autoimmune inflammation

H. Wiendl, M. Rao, T. Magnus, 2006, Experimental Neurology.

Pharmacological Approaches to Delaying Disability Progression in Patients with Multiple Sclerosis

H. Wiendl, S. Meuth, 2015, Drugs.

Real-world disability improvement in patients with relapsing–remitting multiple sclerosis treated with natalizumab in the Tysabri Observational Program

L. Kappos, M. Trojano, H. Wiendl, 2020, Multiple Sclerosis.

["Chronic cerebrospinal venous insufficiency" and multiple sclerosis: critical analysis and first observation in an unselected cohort of MS patients].

R. Hohlfeld, H. Wiendl, R. Gold, 2010, Der Nervenarzt.

[Risk stratification of progressive multifocal leukoencephalopathy under natalizumab: recommendations for JC virus serology].

H. Hartung, F. Zipp, R. Hohlfeld, 2011, Der Nervenarzt.

Defining mechanisms of neural plasticity after brainstem ischemia in rats

H. Wiendl, S. Meuth, W. Schäbitz, 2018, Annals of neurology.

CNS inflammation and neuronal degeneration is aggravated by impaired CD200–CD200R-mediated macrophage silencing

H. Wiendl, S. Meuth, P. Spitzer, 2008, Journal of Neuroimmunology.

K2P18.1 translates T cell receptor signals into thymic regulatory T cell development

U. Dannlowski, T. Marschall, N. Opel, 2021, Cell research.

Therapeutic Apheresis in Acute Relapsing Multiple Sclerosis: Current Evidence and Unmet Needs—A Systematic Review

H. Wiendl, M. Heming, S. Meuth, 2019, Journal of clinical medicine.

Outcome measure : Reporting at least one clinical outcome measure of apheresis

H. Wiendl, M. Heming, S. Meuth, 2019 .

Alemtuzumab therapy changes immunoglobulin levels in peripheral blood and CSF

H. Wiendl, S. Meuth, C. Gross, 2019, Neurology: Neuroimmunology & Neuroinflammation.

The next-generation sphingosine-1 receptor modulator BAF312 (siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis

E. Speckmann, H. Wiendl, S. Meuth, 2019, Neural regeneration research.

Plasma kallikrein modulates immune cell trafficking during neuroinflammation via PAR2 and bradykinin release

H. Wiendl, S. Meuth, C. Gross, 2018, Proceedings of the National Academy of Sciences.

Clinical implications of serum neurofilament in newly diagnosed MS patients: A longitudinal multicentre cohort study

F. Paul, M. Mühlau, H. Hartung, 2020, EBioMedicine.

Rapidly progressive B-cell dominated inflammatory neuropathy and littoral cell angioma of the spleen associated with plasmablastic B-cell lymphoma

K. Müller, H. Wiendl, M. Schilling, 2012, Leukemia & lymphoma.

Exploratory clinical efficacy and patient-reported outcomes from NOVA: A randomized controlled study of intravenous natalizumab 6-week dosing versus continued 4-week dosing for relapsing-remitting multiple sclerosis.

Jeffrey A. Cohen, D. Arnold, H. Wiendl, 2023, Multiple sclerosis and related disorders.

Ocrelizumab Extended Interval Dosing in Multiple Sclerosis in Times of COVID-19

F. Zipp, H. Wiendl, S. Meuth, 2021, Neurology: Neuroimmunology & Neuroinflammation.

Serum neurofilament light and tau as prognostic markers for all-cause mortality in the elderly general population—an analysis from the MEMO study

A. Peters, A. Karch, K. Berger, 2021, BMC Medicine.

CD8+ T-cell immunity in chronic inflammatory demyelinating polyradiculoneuropathy

H. Wiendl, C. Sommer, N. Üçeyler, 2012, Neurology.

CT versus MR Techniques in the Detection of Cervical Artery Dissection

Walter Heindel, Uta Hanning, Heinz Wiendl, 2017, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

B7‐H1 restricts neuroantigen‐specific T cell responses and confines inflammatory CNS damage: Implications for the lesion pathogenesis of multiple sclerosis

Lieping Chen, H. Wiendl, P. Knolle, 2008, European journal of immunology.

Upregulation of K2P5.1 potassium channels in multiple sclerosis

Max-Philipp Stenner, H. Wiendl, S. Meuth, 2010, Annals of neurology.

H. Wiendl, S. Meuth, T. Budde, 2008, Journal of Biological Chemistry.

Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients

H. Wiendl, S. Meuth, T. Budde, 2011, Arthritis Research & Therapy.

Comment on "Functional consequences of Kv1.3 ion channel rearrangement into the immunological synapse".

H. Wiendl, S. Meuth, S. Bittner, 2009, Immunology Letters.

The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice

D. Bayliss, H. Wiendl, S. Meuth, 2009, Neurobiology of Disease.

A novel homozygous missense mutation in the GNE gene of a patient with quadriceps-sparing hereditary inclusion body myopathy associated with muscle inflammation

Wolfgang Müller-Felber, Heinz Wiendl, Sabine Krause, 2003, Neuromuscular Disorders.

SAkuraBONSAI: Protocol design of a novel, prospective study to explore clinical, imaging, and biomarker outcomes in patients with AQP4-IgG-seropositive neuromyelitis optica spectrum disorder receiving open-label satralizumab

A. Traboulsee, R. Sergott, K. Fujihara, 2023, Frontiers in Neurology.

Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension

H. Wiendl, R. Mantegazza, J. Howard, 2020, Neurology.

Safety and efficacy of rozanolixizumab in patients with generalised myasthenia gravis (MycarinG): a randomised, double-blind, placebo-controlled, adaptive phase 3 study

Denny J. Padgett, Adam L. Comer, Yi-Chung Lee, 2023, The Lancet Neurology.

Correction: A β-Lactam Antibiotic Dampens Excitotoxic Inflammatory CNS Damage in a Mouse Model of Multiple Sclerosis

H. Wiendl, S. Meuth, C. Fahlke, 2008, PLoS ONE.

Prominent T-Cell Responses against the Acetylcholine Receptor ε Subunit in Myasthenia Gravis

H. Hartung, H. Wiendl, K. Wiesmüller, 2019, Neurology research international.

Amygdala enlargement and emotional responses in (autoimmune) temporal lobe epilepsy

W. Schwindt, H. Wiendl, S. Meuth, 2018, Scientific Reports.

Impaired Autonomic Responses to Emotional Stimuli in Autoimmune Limbic Encephalitis

W. Schwindt, H. Wiendl, H. Lohmann, 2015, Front. Neurol..

Determinants of cognition in autoimmune limbic encephalitis—A retrospective cohort study

H. Wiendl, S. Meuth, A. Johnen, 2021, Hippocampus.

Genetic variants associated with intrathecal synthesis of IgG, IgM and IgA in multiple sclerosis

F. Paul, U. Ziemann, F. Zipp, 2016 .

Protective potential of dimethyl fumarate in a mouse model of thalamocortical demyelination

H. Pape, E. Speckmann, H. Wiendl, 2018, Brain Structure and Function.

NOX4-derived ROS are neuroprotective by balancing intracellular calcium stores

H. Wiendl, S. Meuth, A. Dinkova-Kostova, 2023, Cellular and Molecular Life Sciences.

Impairment of frequency-specific responses associated with altered electrical activity patterns in auditory thalamus following focal and general demyelination

H. Pape, H. Wiendl, S. Meuth, 2018, Experimental Neurology.

Andexanet-Alfa-Associated Heparin Resistance in the Context of Hemorrhagic Stroke

W. Schwindt, W. Stummer, H. Wiendl, 2022, Neurocritical Care.

Disease control and safety in relapsing remitting multiple sclerosis (RRMS) patients switching from natalizumab to fingolimod: a 32-week, rater- and patient-blind, randomized, parallel-group study (TOFINGO)

X. Montalban, L. Kappos, N. Mueller-Lenke, 2013 .

Long-term effects of dalfampridine in patients with multiple sclerosis

H. Wiendl, S. Meuth, T. Ruck, 2014, Journal of the Neurological Sciences.

Subcortical Volumes as Early Predictors of Fatigue in Multiple Sclerosis

H. Hartung, V. Fleischer, F. Zipp, 2021, Annals of neurology.

Long-term safety and effectiveness of natalizumab treatment in clinical practice: 10 years of real-world data from the Tysabri Observational Program (TOP)

L. Kappos, M. Trojano, H. Wiendl, 2020, Journal of Neurology, Neurosurgery, and Psychiatry.

Comparative efficacy of first-line natalizumab vs IFN-&bgr; or glatiramer acetate in relapsing MS

L. Kappos, J. Lechner-Scott, M. Trojano, 2016, Neurology. Clinical practice.

Evidence for early, non-lesional cerebellar damage in patients with multiple sclerosis: DTI measures correlate with disability, atrophy, and disease duration

Frauke Zipp, Karsten Tabelow, Michael Deppe, 2016, Multiple sclerosis.

A double‐blind, randomized, placebo‐controlled phase 2 trial evaluating the selective dihydroorotate dehydrogenase inhibitor vidofludimus calcium in relapsing‐remitting multiple sclerosis

H. Wiendl, R. Fox, K. Rejdak, 2022, Annals of clinical and translational neurology.

Multiple sclerosis therapy: An update on recently finished trials

H. Wiendl, S. Meuth, B. Kieseier, 2007, Journal of Neurology.

Response to eculizumab in patients with myasthenia gravis recently treated with chronic IVIg: a subgroup analysis of REGAIN and its open-label extension study

H. Wiendl, J. Howard, F. O'Brien, 2020, Therapeutic advances in neurological disorders.

Immunomodulatory treatment strategies in multiple sclerosis

H. Wiendl, B. Kieseier, O. Stüve, 2008, Journal of Neurology.

DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis

Hannes P. Eggertsson, Till F. M. Andlauer, Bjarni V. Halldórsson, 2018, Nature Communications.

Review and Analysis of International Case-Control Studies on CCSVI and Multiple Sclerosis

W. Oertel, H. Hartung, H. Wiendl, 2013 .

Early effective treatment may protect from cognitive decline in paediatric multiple sclerosis.

H. Wiendl, S. Meuth, H. Lohmann, 2019, European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.

Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell–mediated limbic encephalitis

C. Elger, H. Wiendl, S. Meuth, 2023, Science advances.

A human post-mortem brain model for the standardization of multi-centre MRI studies

Till Acker, Frauke Zipp, Ralf Deichmann, 2015, NeuroImage.

Complement activation profiles in anti‐acetylcholine receptor positive myasthenia gravis

J. Lünemann, H. Wiendl, C. Gross, 2023, European journal of neurology.

Accelerated course of experimental autoimmune encephalomyelitis in PD-1-deficient central nervous system myelin mutants.

K. Nave, H. Wiendl, K. Göbel, 2009, The American journal of pathology.

The Contribution of TWIK-Related Acid-Sensitive K+-Containing Channels to the Function of Dorsal Lateral Geniculate Thalamocortical Relay Neurons

H. Pape, H. Wiendl, W. Wisden, 2006, Molecular Pharmacology.

PD-1 Regulates Neural Damage in Oligodendroglia-Induced Inflammation

K. Nave, H. Wiendl, R. Martini, 2009, PloS one.

Antigen recognition properties of a Vγ1.3Vδ2-T-cell receptor from a rare variant of polymyositis

Reinhard Hohlfeld, Heinz Wiendl, R. Hohlfeld, 2004, Journal of Neuroimmunology.

Immune Cell Profiling during Switching from Natalizumab to Fingolimod Reveals Differential Effects on Systemic Immune-Regulatory Networks and on Trafficking of non-T Cell Populations into the CSF – Results from the ToFingo Successor Study (S52.002)

H. Wiendl, A. Schulte-Mecklenbeck, S. Meuth, 2018 .

[Revision of McDonald's new diagnostic criteria for multiple sclerosis].

H. Hartung, R. Hohlfeld, H. Wiendl, 2006, Der Nervenarzt.

Visually Evoked Potential as Prognostic Biomarker for Neuroaxonal Damage in Multiple Sclerosis From a Multicenter Longitudinal Cohort

H. Wiendl, S. Meuth, J. Bellmann-Strobl, 2023, Neurology: Neuroimmunology & Neuroinflammation.

Multiple sclerosis therapy consensus group (MSTCG): answers to the discussion questions

J. Lünemann, A. Gass, C. Enzinger, 2021, Neurological Research and Practice.

Effectiveness and safety of cladribine in MS: Real-world experience from two tertiary centres

H. Wiendl, S. Meuth, T. Ruck, 2021, Multiple sclerosis.

Generation of a Model to Predict Differentiation and Migration of Lymphocyte Subsets under Homeostatic and CNS Autoinflammatory Conditions

M. Herty, H. Wiendl, A. Schulte-Mecklenbeck, 2020, International journal of molecular sciences.

Comparing Plasma Exchange to Escalated Methyl Prednisolone in Refractory Multiple Sclerosis Relapses

H. Wiendl, S. Meuth, T. Ruck, 2019, Journal of clinical medicine.

Characterisation of MS phenotypes across the age span using a novel data set integrating 34 clinical trials (NO.MS cohort): Age is a key contributor to presentation

Thomas E. Nichols, D. Arnold, H. Ganjgahi, 2021, Multiple sclerosis.

Multiple Sklerose Therapie Konsensus Gruppe (MSTKG): Positionspapier zur verlaufsmodifizierenden Therapie der Multiplen Sklerose 2021 (White Paper)

Zoë R. Hunter, J. Lünemann, A. Gass, 2021, Der Nervenarzt.

Skin Reactions in Patients With Multiple Sclerosis Receiving Cladribine Treatment

W. Sondermann, H. Wiendl, S. Meuth, 2021, Neurology: Neuroimmunology & Neuroinflammation.

Daclizumab HYP versus Interferon Beta-1a in Relapsing Multiple Sclerosis.

D. Arnold, L. Kappos, S. Greenberg, 2015, The New England journal of medicine.

Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study.

M. Mühlau, M. Ploner, H. Hartung, 2020, Pain.

Varicella zoster virus and influenza vaccine antibody titres in patients from MAGNIFY-MS who were treated with cladribine tablets for highly active relapsing multiple sclerosis

D. Centonze, K. Schmierer, H. Wiendl, 2022, Multiple sclerosis.

Early silent microstructural degeneration and atrophy of the thalamocortical network in multiple sclerosis

W. Schwindt, H. Wiendl, S. Meuth, 2016, Human brain mapping.

Efficacy of alemtuzumab in relapsing-remitting MS patients who received additional courses after the initial two courses: Pooled analysis of the CARE-MS, extension, and TOPAZ studies

P. Vermersch, A. Traboulsee, B. Sharrack, 2019, Multiple sclerosis.

Neuroimmunotherapies Targeting T Cells: From Pathophysiology to Therapeutic Applications

H. Wiendl, S. Bittner, 2015, Neurotherapeutics.

Confirmed 6-Month Disability Improvement and Worsening Correlate with Long-term Disability Outcomes in Alemtuzumab-Treated Patients with Multiple Sclerosis: Post Hoc Analysis of the CARE-MS Studies

C. Pozzilli, P. Vermersch, B. Sharrack, 2021, Neurology and Therapy.

Teriflunomide treatment is associated with optic nerve recovery in early multiple sclerosis

H. Wiendl, S. Meuth, M. Pawlitzki, 2021, Therapeutic advances in neurological disorders.

Expert opinion on the long-term use of cladribine tablets for multiple sclerosis: Systematic literature review of real-world evidence.

D. Centonze, P. Vermersch, E. Celius, 2022, Multiple sclerosis and related disorders.

Fingolimod treatment promotes regulatory B-cell phenotype and function in multiple sclerosis

H. Wiendl, B. Kieseier, B. Wildemann, 2014, Journal of Neuroimmunology.

Altered neuronal expression of TASK1 and TASK3 potassium channels in rodent and human autoimmune CNS inflammation

H. Wiendl, S. Meuth, T. Budde, 2008, Neuroscience Letters.

Mechanisms underlying lesion development and lesion distribution in CNS autoimmunity

H. Wiendl, L. Klotz, M. Lindner, 2018, Journal of neurochemistry.

Treatment choices and neuropsychological symptoms of a large cohort of early MS

A. Ziegler, F. Paul, U. Ziemann, 2018, Neurology: Neuroimmunology & Neuroinflammation.

Hyponatremia upon presentation to the emergency department – the need for urgent neuroimaging studies

W. Schwindt, H. Wiendl, H. Pavenstädt, 2017, Scientific Reports.

Reply to Liu et al.: Haplotype matters: CD226 polymorphism as a potential trigger for impaired immune regulation in multiple sclerosis

H. Wiendl, A. Schulte-Mecklenbeck, S. Meuth, 2017, Proceedings of the National Academy of Sciences.

Identification of inflammatory neuronal injury and prevention of neuronal damage in multiple sclerosis: hope for novel therapies?

Frauke Zipp, Ralf Gold, Heinz Wiendl, 2013, JAMA neurology.

Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus

H. Wiendl, T. Kuhlmann, T. Korn, 2018, Journal of Neuroinflammation.

Substance P Saliva Reduction Predicts Pharyngeal Dysphagia in Parkinson's Disease

H. Wiendl, S. Meuth, T. Warnecke, 2019, Front. Neurol..

Gaps Between Aims and Achievements in Therapeutic Modification of Neuronal Damage (“Neuroprotection”)

C. Elger, W. Oertel, H. Reichmann, 2015, Neurotherapeutics.

[Dementia as a primary symptom in late onset multiple sclerosis. Case series and review of the literature].

H. Wiendl, C. Laske, G. Buchkremer, 2005, Der Nervenarzt.

Treatment of active secondary progressive multiple sclerosis with treosulfan

M. Weller, H. Wiendl, U. Pichlmeier, 2007, Journal of Neurology.

Trafficking of lymphocytes into the CNS

H. Wiendl, N. Schwab, T. Schneider-Hohendorf, 2015, Oncotarget.

Disease-modifying treatments and cognition in relapsing-remitting multiple sclerosis

H. Hartung, H. Wiendl, S. Meuth, 2020, Neurology.

Natalizumab restores evoked potential abnormalities in patients with relapsing–remitting multiple sclerosis

H. Wiendl, S. Meuth, S. Bittner, 2011, Multiple sclerosis.

Vaccine Response in Patients With Multiple Sclerosis Receiving Teriflunomide

A. Bar-Or, S. S. Geertsen, H. Wiendl, 2022, Frontiers in Neurology.

Efficacy of alemtuzumab over 6 years in relapsing–remitting multiple sclerosis patients who relapsed between courses 1 and 2: Post hoc analysis of the CARE-MS studies

C. Pozzilli, P. Vermersch, S. Broadley, 2019, Multiple sclerosis.

Immune Cells Contribute to Myelin Degeneration and Axonopathic Changes in Mice Overexpressing Proteolipid Protein in Oligodendrocytes

K. Nave, H. Wiendl, M. Bendszus, 2006, The Journal of Neuroscience.

Seizures and epilepsy in multiple sclerosis: epidemiology and prognosis in a large tertiary referral center

C. Elger, H. Wiendl, S. Meuth, 2019, Journal of Neurology.

Assessment of immune functions and MRI disease activity in relapsing-remitting multiple sclerosis patients switching from natalizumab to fingolimod (ToFingo-Successor)

H. Wiendl, S. Meuth, C. Gross, 2015, BMC Neurology.

Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis

F. Paul, M. Hecker, M. Mühlau, 2019, Multiple sclerosis.

[Current aspects of therapy conversion for multiple sclerosis].

H. Hartung, V. Fleischer, W. Brück, 2015, Der Nervenarzt.

Apraxia screening predicts Alzheimer pathology in frontotemporal dementia

H. Wiendl, S. Meuth, A. Johnen, 2018, Journal of Neurology, Neurosurgery, and Psychiatry.

Circulating lymphocyte levels and relationship with infection status in patients with relapsing–remitting multiple sclerosis treated with daclizumab beta

H. Wiendl, G. Giovannoni, G. Giannattasio, 2018, Multiple sclerosis.

Serum Glial Fibrillary Acidic Protein Compared With Neurofilament Light Chain as a Biomarker for Disease Progression in Multiple Sclerosis.

M. Battaglini, C. Granziera, L. Kappos, 2023, JAMA neurology.

Relevance of raised cerebrospinal fluid monocyte levels in patients with frontotemporal dementia

H. Wiendl, S. Meuth, C. Gross, 2018, Neurobiology of Aging.

CD62L test at 2 years of natalizumab predicts progressive multifocal leukoencephalopathy

P. Vermersch, S. Vukusic, B. Brochet, 2016, Neurology.

Novel pathomechanisms in inflammatory neuropathies

H. Wiendl, D. Schafflick, Gerd Meyer zu Horste, 2017, Journal of Neuroinflammation.

4-Aminopyridine ameliorates mobility but not disease course in an animal model of multiple sclerosis

H. Wiendl, S. Meuth, T. Budde, 2013, Experimental Neurology.

New evidence for teriflunomide in multiple sclerosis

H. Wiendl, B. Kieseier, 2014, The Lancet Neurology.

Patients with a relapsing course of steroid‐responsive encephalopathy associated with autoimmune thyroiditis exhibit persistent intrathecal CD4+ T‐cell activation

H. Wiendl, S. Meuth, M. Pawlitzki, 2020, European Journal of Neurology.

EMR-integrated minimal core dataset for routine health care and multiple research settings: A case study for neuroinflammatory demyelinating diseases

Philipp Neuhaus, Martin Dugas, Klaus Berger, 2019, PloS one.

Highlights from the 31st ECTRIMS congress – Barcelona 2015

H. Wiendl, J. Sastre-Garriga, 2016, Multiple sclerosis.

[Multiple sclerosis -- a channelopathy? Targeting ion channels and transporters in inflammatory neurodegeneration].

H. Wiendl, T. Budde, C. Kleinschnitz, 2009, Der Nervenarzt.

Diffusion Abnormality in Balo’s Concentric Sclerosis: Clues for the Pathogenesis

H. Wiendl, U. Herrlinger, W. Küker, 2004, European Neurology.

Consistent efficacy of daclizumab beta across patient demographic and disease activity subgroups in patients with relapsing-remitting multiple sclerosis.

L. Kappos, H. Wiendl, R. Gold, 2017, Multiple Sclerosis and Related Disorders.

Escalating immunotherapy of multiple sclerosis--new aspects and practical application.

K. Hess, A. Gass, L. Kappos, 2004, Journal of neurology.

Postpartum disease activity and breastfeeding in multiple sclerosis revisited

H. Wiendl, B. Kieseier, 2010, Neurology.

A case of idiopathic multicentric Castleman disease in an alemtuzumab-treated patient with MS

H. Wiendl, S. Meuth, H. Pavenstädt, 2019, Neurology: Neuroimmunology & Neuroinflammation.

Pretreatment anti-thyroid autoantibodies indicate increased risk for thyroid autoimmunity secondary to alemtuzumab: A prospective cohort study

H. Wiendl, A. Schulte-Mecklenbeck, M. Heming, 2019, EBioMedicine.

Monomethylfumarate reduces in vitro migration of mononuclear cells

H. Hartung, H. Wiendl, B. Kieseier, 2014, Neurological Sciences.

Efficacy of daclizumab beta versus intramuscular interferon beta-1a on disability progression across patient demographic and disease activity subgroups in DECIDE

L. Kappos, S. Greenberg, H. Wiendl, 2017, Multiple sclerosis.

[Monitoring of blood parameters under course-modified MS therapy : Substance-specific relevance and current recommendations for action].

F. Paul, W. Brück, F. Zipp, 2016, Der Nervenarzt.

TERI-DYNAMIC: Exploring the Impact of Teriflunomide on Immune Cell Population Size, Receptor Repertoire, and Function in Patients With RRMS (P5.282)

A. Bar-Or, H. Wiendl, A. Schulte-Mecklenbeck, 2016 .

Daclizumab HYP Versus Interferon Beta-1a in Relapsing-Remitting Multiple Sclerosis: Primary Results of the DECIDE Study (S4.003)

D. Arnold, L. Kappos, S. Greenberg, 2015 .

[Acute disseminated encephalomyelitis. Pathogenesis, diagnosis, treatment, and prognosis].

H. Hartung, H. Wiendl, S. Nessler, 2005, Der Nervenarzt.

Acute transverse myelitis associated with coxiella burnetii infection

J. Dichgans, M. Weller, H. Wiendl, 2002, Journal of Neurology.

Daclizumab HYP versus Interferon β-1a across Patient Demographic and Disease Activity Subgroups in the DECIDE Phase 3 Study (P4.007)

S. Greenberg, H. Wiendl, E. Havrdová, 2015 .

OBSERVATION CD 4 T Cells Predominate in Cerebrospinal Fluid and Leptomeningeal and Parenchymal Infiltrates in Cerebral Amyloid – Related Angiitis

W. Stummer, H. Wiendl, S. Meuth, 2012 .

Optimized synthesis and pharmacological evaluation of HCN channel inhibitor EC18

H. Wiendl, S. Meuth, T. Budde, 2023, Archiv der Pharmazie.

Intra-ocular dendritic cells are increased in HLA-B27 associated acute anterior uveitis

A. Heiligenhaus, H. Wiendl, D. Schafflick, 2021, bioRxiv.

Cytotoxic CD8+ T cells and CD138+ plasma cells prevail in cerebrospinal fluid in non-paraneoplastic cerebellar ataxia with contactin-associated protein-2 antibodies

H. Wiendl, S. Meuth, C. Gross, 2012, Journal of Neuroinflammation.

Profiling Complement System Components in Primary CNS Vasculitis

C. Gerloff, J. Lünemann, H. Wiendl, 2021, Cells.

Iatrogenic immunosuppression with biologics in MS

H. Wiendl, O. Stüve, 2009, Neurology.

Anti-JC-virus antibody prevalence in a German MS cohort

H. Hartung, B. Hemmer, H. Wiendl, 2012, Multiple sclerosis.

Neuromyelitis optica

H. Wiendl, C. Ip, 2008 .

Enhanced pathogenicity of Th17 cells due to natalizumab treatment: Implications for MS disease rebound

H. Wiendl, D. Schafflick, A. Schulte-Mecklenbeck, 2022, Proceedings of the National Academy of Sciences of the United States of America.

No effect of immunomodulatory therapy in focal epilepsy with positive glutamate receptor type 3—antibodies

F. Fazekas, E. Körner, H. Wiendl, 2006, Seizure.

Prospective validation of the PML risk biomarker l-selectin and influence of natalizumab extended intervals

H. Wiendl, S. Meuth, C. Gross, 2019, Neurology.

Dietary Conjugated Linoleic Acid Supplementation Modulates CNS Autoimmunity (P2.413)

K. Berer, G. Krishnamoorthy, H. Wiendl, 2018 .

Delayed onset and reduced disease severity of spontaneous CNS autoimmunity by conjugated linoleic acid-rich diet (P2.217)

H. Wiendl, T. Kuhlmann, L. Klotz, 2015 .

[Frequency and risk factors associated with post-stroke dementia-an observational study on stroke patients without premorbid cognitive impairment].

H. Wiendl, S. Meuth, H. Lohmann, 2019, Der Nervenarzt.

Secretomics reveals gelatinase substrates at the blood-brain barrier that are implicated in astroglial barrier function

H. Wiendl, T. Kuhlmann, C. Gross, 2023, Science advances.

Phospholipase D1 mediates lymphocyte adhesion and migration in experimental autoimmune encephalomyelitis

H. Wiendl, S. Meuth, B. Nieswandt, 2014, European journal of immunology.

Learning multiple sclerosis immunopathogenesis from anti-CD20 therapy

H. Wiendl, M. Heming, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Stroke in Patients with Bacterial Meningitis: A Cohort Study and Meta‐Analysis

W. Schwindt, H. Wiendl, A. Schulte-Mecklenbeck, 2023, Annals of neurology.

Immunophenotyping of cerebrospinal fluid cells by Chipcytometry

H. Wiendl, C. Gross, M. Stangel, 2018, Journal of Neuroinflammation.

Why a positive genetic test for myotonic dystrophy type I does not always imply the right diagnosis

C. Wessig, H. Wiendl, S. Meuth, 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[Concepts of lesion development in multiple sclerosis. Current approaches and clinical-therapeutic implications ].

H. Wiendl, C. Trebst, M. Stangel, 2006, Der Nervenarzt.

Can cognitive assessment really discriminate early stages of Alzheimer’s and behavioural variant frontotemporal dementia at initial clinical presentation?

H. Wiendl, H. Lohmann, A. Johnen, 2017, Alzheimer's Research & Therapy.

Murine K2P5.1 Deficiency Has No Impact on Autoimmune Neuroinflammation due to Compensatory K2P3.1- and KV1.3-Dependent Mechanisms

W. Brück, H. Wiendl, S. Meuth, 2015, International journal of molecular sciences.

Prothrombin and factor X are elevated in multiple sclerosis patients

H. Wiendl, S. Meuth, C. Gross, 2016, Annals of neurology.

CD4+ CD25+ FoxP3+ regulatory T cells suppress cytotoxicity of CD8+ effector T cells: implications for their capacity to limit inflammatory central nervous system damage at the parenchymal level

H. Wiendl, S. Meuth, S. Bittner, 2012, Journal of Neuroinflammation.

Serum neurofilament light and white matter characteristics in the general population: a longitudinal analysis.

H. Wiendl, P. Benkert, J. Kuhle, 2023, GeroScience.

Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G

M. Fluegge, H. Wiendl, A. Jacobs, 2017, Oncoimmunology.

Human myoblasts modulate the function of antigen-presenting cells

H. Wiendl, Hanns Lochmüller, N. Schwab, 2008, Journal of Neuroimmunology.

Daclizumab HYP versus Interferon Beta-1a in Relapsing Multiple Sclerosis.

D. Arnold, L. Kappos, S. Greenberg, 2015, The New England journal of medicine.

Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk

Till F. M. Andlauer, H. Ullum, T. Werge, 2018, Cell.

Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation.

H. Wiendl, G. Stoll, Tobias J. Schwarz, 2010, Blood.

Analysis of Lymphocyte Extravasation Using an In Vitro Model of the Human Blood-brain Barrier.

H. Wiendl, A. Schulte-Mecklenbeck, C. Gross, 2017, Journal of visualized experiments : JoVE.

Dietary salt promotes ischemic brain injury and is associated with parenchymal migrasome formation

C. Sommer, H. Wiendl, J. Minnerup, 2018, PloS one.

An Imbalance of Two Functionally and Phenotypically Different Subsets of Plasmacytoid Dendritic Cells Characterizes the Dysfunctional Immune Regulation in Multiple Sclerosis

H. Wiendl, K. Toyka, B. Kieseier, 2010, The Journal of Immunology.

CNS inflammation and neuronal degeneration is aggravated by impaired CD200–CD200R-mediated macrophage silencing

H. Wiendl, S. Meuth, P. Spitzer, 2008, Journal of Neuroimmunology.

Does the environment influence multiple sclerosis pathogenesis via UVB light and/or induction of vitamin D?

H. Wiendl, K. Loser, N. Mykicki, 2019, Journal of Neuroimmunology.

Modulation of neuronal activity by the endogenous pentapeptide QYNAD

M. Weller, H. Wiendl, S. Meuth, 2003, The European journal of neuroscience.

Active immunization with proteolipid protein (190-209) induces ascending paralysing experimental autoimmune encephalomyelitis in C3H/HeJ mice.

H. Wiendl, S. Meuth, T. Budde, 2011, Journal of immunological methods.

Reduced cortisol levels in cerebrospinal fluid and differential distribution of 11β-hydroxysteroid dehydrogenases in multiple sclerosis: Implications for lesion pathogenesis

H. Wiendl, M. Buttmann, M. Mehling, 2010, Brain, Behavior, and Immunity.

Facing the challenges of chronic pruritus: a report from a multi-disciplinary medical itch centre in Germany.

W. Heindel, B. Pfleiderer, H. Wiendl, 2015, Acta Dermato-Venereologica.

CD4(+)HLA-G(+) regulatory T cells: Molecular signature and pathophysiological relevance.

H. Wiendl, S. Meuth, T. Ruck, 2016, Human immunology.

The role of regulatory T cells in multiple sclerosis

H. Wiendl, A. Zozulya, 2008, Nature Clinical Practice Neurology.

Dendritic cell vaccination in autoimmune disease

H. Wiendl, C. Gross, 2013, Current opinion in rheumatology.

Upregulation of K2P5.1 potassium channels in multiple sclerosis

Max-Philipp Stenner, H. Wiendl, S. Meuth, 2010, Annals of neurology.

Efficacy and safety of ocrelizumab in patients with relapsing-remitting multiple sclerosis with a suboptimal response to previous disease-modifying therapies (1‑year interim results)

P. Vermersch, G. Comi, H. Wiendl, 2019, Journal of the Neurological Sciences.

Efficacy and Safety of Ocrelizumab in Patients with Relapsing-Remitting Multiple Sclerosis with a Suboptimal Response to Previous Disease-Modifying Therapies (1-Year Interim Results)

P. Vermersch, H. Wiendl, R. Nicholas, 2020 .

CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery.

A. Becker, H. Wiendl, C. Bien, 2009, Brain : a journal of neurology.

Amygdala enlargement and emotional responses in (autoimmune) temporal lobe epilepsy

W. Schwindt, H. Wiendl, S. Meuth, 2018, Scientific Reports.

Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus

H. Wiendl, T. Kuhlmann, T. Korn, 2018, Journal of Neuroinflammation.

An autoreactive gamma delta TCR derived from a polymyositis lesion.

R. Hohlfeld, H. Wiendl, H. Wekerle, 2002, Journal of immunology.

Shared neural correlates of limb apraxia in early stages of Alzheimer's dementia and behavioural variant frontotemporal dementia

H. Wiendl, H. Lohmann, A. Johnen, 2016, Cortex.

Neuroinflammation: the world is not enough.

H. Wiendl, 2012, Current opinion in neurology.

NMO Spectrum Disorders

H. Wiendl, S. Pfeuffer, C. Strippel, 2017, Neurology International Open.

Prothrombin and factor X are elevated in multiple sclerosis patients

H. Wiendl, S. Meuth, C. Gross, 2016, Annals of neurology.

Correction: CD4+NKG2D+ T Cells Exhibit Enhanced Migratory and Encephalitogenic Properties in Neuroinflammation

H. Wiendl, S. Meuth, T. Kuhlmann, 2013, PLoS ONE.

Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice

H. Wiendl, K. Dornmair, R. Martini, 2007, Molecular and Cellular Neuroscience.

Ion channels in autoimmune neurodegeneration

H. Wiendl, S. Meuth, T. Budde, 2011, FEBS Letters.

Lack of evidence for a pathogenic role of T-lymphocytes in an animal model for Charcot-Marie-Tooth disease 1A

C. Wessig, H. Wiendl, R. Martini, 2010, Neurobiology of Disease.

The Development of Ofatumumab, a Fully Human Anti-CD20 Monoclonal Antibody for Practical Use in Relapsing Multiple Sclerosis Treatment

L. Kappos, P. Vermersch, A. Bar-Or, 2023, Neurology and Therapy.