S. Orrenius

发表

Mitochondria in cancer cells: what is so special about them?

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2008, Trends in cell biology.

DNA damage induces two distinct modes of cell death in ovarian carcinomas

B. Zhivotovsky, S. Orrenius, C. Tamm, 2008, Cell Death and Differentiation.

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

S. Lipton, B. Zhivotovsky, S. Orrenius, 1995, Neuron.

Calcium and mitochondria in the regulation of cell death.

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2015, Biochemical and biophysical research communications.

Susceptibility of different subsets of immature thymocytes to apoptosis

G. Cohen, S. Orrenius, S. Chow, 1997, FEBS letters.

Apoptosis in human disease: a new skin for the old ceremony?

B. Zhivotovsky, S. Orrenius, B. Fadeel, 1999, Biochemical and biophysical research communications.

Calcium: Regulation of cell death: the calcium–apoptosis link

Sten Orrenius, Boris Zhivotovsky, Pierluigi Nicotera, 2003, Nature Reviews Molecular Cell Biology.

Multiple proteases are involved in thymocyte apoptosis.

B. Zhivotovsky, S. Orrenius, P. Nicotera, 1995, Experimental cell research.

Two different proteases are involved in the proteolysis of lamin during apoptosis.

B. Zhivotovsky, S. Orrenius, A. Gahm, 1997, Biochemical and biophysical research communications.

Biotransformation of bromobenzene to reactive metabolites by isolated hepatocytes.

S. Orrenius, H. Thor, S. Svensson, 1981, Advances in experimental medicine and biology.

[4] Isolation and use of liver cells

Sten Orrenius, Johan Högberg, S. Orrenius, 1978 .

Metabolic activation and hepatotoxicity: Metabolism of bromobenzene in isolated hepatocytes☆

S. Orrenius, D. J. Reed, J. Högberg, 1978 .

Metabolic activation and hepatotoxicity. Toxicity of bromobenzene in hepatocytes isolated from phenobarbital-and diethylmaleate-treated rats.

S. Orrenius, D. J. Reed, J. Högberg, 1978, Archives of biochemistry and biophysics.

Critical role of sulfhydryl group(s) in ATP‐dependent Ca2+ sequestration by the plasma membrane fraction from rat liver

S. Orrenius, G. Bellomo, P. Richelmi, 1983, FEBS letters.

Menadione-induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis.

D. D. Di Monte, S. Orrenius, P. Nicotera, 1984, Archives of biochemistry and biophysics.

Caspase-2 function in response to DNA damage.

B. Zhivotovsky, S. Orrenius, 2005, Biochemical and biophysical research communications.

Mitochondria, oxidative stress and cell death

Sten Orrenius, Boris Zhivotovsky, Martin Ott, 2007, Apoptosis.

Ion Signalling in Apoptosis

B. Zhivotovsky, S. Orrenius, P. Nicotera, 1994 .

A Role for Oxidative Stress in Apoptosis: Oxidation and Externalization of Phosphatidylserine Is Required for Macrophage Clearance of Cells Undergoing Fas-Mediated Apoptosis1

Sten Orrenius, Bengt Fadeel, Valerian E. Kagan, 2002, The Journal of Immunology.

On the role of Ca2+ in the toxicity of alkylating and oxidizing quinone imines in isolated hepatocytes.

S. Orrenius, P. Nicotera, P. Moldéus, 1989, Chemical research in toxicology.

Further characterization of the events involved in mitochondrial Ca2+ release and pore formation by prooxidants.

S. Orrenius, G. Kass, M. Weis, 1994, Biochemical pharmacology.

m‐Iodobenzylguanidine increases the mitochondrial Ca2+ pool in isolated hepatocytes

S. Orrenius, G. Kass, M. J. Juedes, 1992, FEBS letters.

Evidence for two pathways of receptor-mediated Ca2+ entry in hepatocytes.

S. Orrenius, G. Kass, J. Llopis, 1992, The Biochemical journal.

Tributyltin stimulates apoptosis in rat thymocytes.

T. Aw, S. Orrenius, P. Nicotera, 1990, Archives of biochemistry and biophysics.

Ca2+-dependent mechanisms of cytotoxicity and programmed cell death

S. Orrenius, P. Nicotera, M. McCabe, 1992 .

Ca(2+)-dependent mechanisms of cytotoxicity and programmed cell death.

S. Orrenius, P. Nicotera, M. McCabe, 1992, Toxicology letters.

CPP32/Apopain Is a Key Interleukin 1 Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis (*)

S. Orrenius, N. Thornberry, Douglas K. Miller, 1996, The Journal of Biological Chemistry.

The role of methionine in glutathione biosynthesis by isolated hepatocytes.

S. Orrenius, D. J. Reed, S. Orrenius, 1977, Biochemical and biophysical research communications.

Electron microscopic observations on iron-labelled secondary lysosomes in renal tubules in mice

S. Orrenius, J. Ericsson, A. Engberg, 2004, Zeitschrift für Zellforschung und Mikroskopische Anatomie.

Calcium-Dependent Mechanisms in Drug Toxicity and Cell Killing

C. Heizmann, S. Orrenius, G. Bellomo, 1995 .

Toxicity of S-pentachlorobutadienyl-L-cysteine studied with isolated rat renal cortical mitochondria.

A. Vercesi, S. Orrenius, I. Cotgreave, 1987, Archives of biochemistry and biophysics.

Intracellular Ca2+ signals activate apoptosis in thymocytes: studies using the Ca(2+)-ATPase inhibitor thapsigargin.

S. Orrenius, P. Nicotera, S. Chow, 1994, Experimental cell research.

Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis

B. Zhivotovsky, S. Orrenius, T. Noma, 1999, FEBS letters.

Rapid and Specific Efflux of Reduced Glutathione during Apoptosis Induced by Anti-Fas/APO-1 Antibody*

S. Orrenius, I. Cotgreave, D. J. van den Dobbelsteen, 1996, The Journal of Biological Chemistry.

Mechanism of dithiocarbamate inhibition of apoptosis: thiol oxidation by dithiocarbamate disulfides directly inhibits processing of the caspase-3 proenzyme.

D. H. Burgess, B. Zhivotovsky, S. Orrenius, 1997, Chemical research in toxicology.

Dithiocarbamates Induce Apoptosis in Thymocytes by Raising the Intracellular Level of Redox-active Copper (*)

S. Orrenius, B. Lind, A. Slater, 1995, The Journal of Biological Chemistry.

Disulfiram is a potent inhibitor of proteases of the caspase family.

S. Orrenius, D. Nicholson, A. Slater, 1997, Chemical research in toxicology.

Dithiocarbamate toxicity toward thymocytes involves their copper-catalyzed conversion to thiuram disulfides, which oxidize glutathione in a redox cycle without the release of reactive oxygen species.

S. Orrenius, S. Tsang, M. Burkitt, 1998, Archives of biochemistry and biophysics.

Ca2(+)-mobilizing hormones stimulate Ca2+ efflux from hepatocytes.

S. Orrenius, G. Kass, S. Duddy, 1989, The Journal of biological chemistry.

Oxidative stress studied in intact mammalian cells.

S. Orrenius, 1985, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Biochemical mechanisms of oxidative liver cell injury.

S. Orrenius, P. Nicotera, 1987, Bulletin europeen de physiopathologie respiratoire.

Recent studies on cytochrome P-450-linked functions in isolated rat liver cells.

S. Orrenius, P. Moldéus, R. Grundin, 1975, Forensic science.

Heat shock proteins: regulators of stress response and apoptosis.

S. Orrenius, Afshin Samali, 1998, Cell stress & chaperones.

Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c.

S. Orrenius, C. Concannon, Afshin Samali, 2001, Gene expression.

Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes.

D. D. Di Monte, S. Orrenius, D. Ross, 1984, Archives of biochemistry and biophysics.

Formation and reduction of glutathione-protein mixed disulfides during oxidative stress. A study with isolated hepatocytes and menadione (2-methyl-1,4-naphthoquinone).

S. Orrenius, G. Bellomo, P. Richelmi, 1987, Biochemical pharmacology.

Demonstration of nuclear compartmentalization of glutathione in hepatocytes.

S. Orrenius, G. Bellomo, L. Stivala, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Redox regulation of apoptotic cell death

S. Orrenius, M. Hampton, 1998, BioFactors.

1,10-Phenanthroline stimulates internucleosomal DNA fragmentation in isolated rat-liver nuclei by promoting the redox activity of endogenous copper ions.

S. Orrenius, P. Nicotera, M. Burkitt, 1996, The Biochemical journal.

Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C.

S. Orrenius, D. McConkey, P. Hartzell, 1989, The Journal of biological chemistry.

The calcium ion and cell death.

S. Orrenius, P. Nicotera, 1994, Journal of neural transmission. Supplementum.

Accumulation of 99Tcm-gluconate in isolated rat cardiac myocytes and hepatocytes during anoxia.

S. Orrenius, N. Ahlberg, J. Rajs, 1979, Acta radiologica: oncology, radiation, physics, biology.

Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines.

S. Orrenius, P. Nicotera, M. Ankarcrona, 1994, The Journal of biological chemistry.

Cystamine induces toxicity in hepatocytes through the elevation of cytosolic Ca2+ and the stimulation of a nonlysosomal proteolytic system.

S. Orrenius, P. Nicotera, G. Bellomo, 1986, The Journal of biological chemistry.

Chromatin condensation during apoptosis requires ATP.

S. Orrenius, J. Eriksson, G. Kass, 1996, The Biochemical journal.

Opening of plasma membrane voltage-dependent anion channels (VDAC) precedes caspase activation in neuronal apoptosis induced by toxic stimuli

S. Orrenius, S. Ceccatelli, Y. Tsujimoto, 2005, Cell Death and Differentiation.

The effect of albumin on the metabolism of ethoxyresorufin through O-deethylation and sulphate-conjugation using isolated rat hepatocytes.

S. Orrenius, M. Burke, 1978, Biochemical pharmacology.

Molecular Mechanisms of Oxidative Cell Damage

S. Orrenius, 1990 .

Alterations in hepatocyte cytoskeleton caused by redox cycling and alkylating quinones.

G. Cohen, S. Orrenius, G. Bellomo, 1988, Archives of biochemistry and biophysics.

Menadione-induced bleb formation in hepatocytes is associated with the oxidation of thiol groups in actin.

S. Orrenius, G. Bellomo, A. Salis, 1988, Archives of biochemistry and biophysics.

Alterations of surface morphology caused by the metabolism of menadione in mammalian cells are associated with the oxidation of critical sulfhydryl groups in cytoskeletal proteins.

S. Orrenius, F. Taddei, G. Bellomo, 1988, Biochemical pharmacology.

The formation of plasma membrane blebs in hepatocytes exposed to agents that increase cytosolic Ca2+ is mediated by the activation of a non‐lysosomal proteolytic system

S. Orrenius, P. Nicotera, P. Hartzell, 1986, FEBS letters.

Mitochondrial regulation of apoptotic cell death.

S. Orrenius, 2003, Toxicology letters.

Cardiolipin oxidation sets cytochrome c free

B. Zhivotovsky, S. Orrenius, 2005, Nature chemical biology.

ON THE RELATIONSHIP OF LIVER GLUCOSE-6-PHOSPHATASE TO THE PROLIFERATION OF ENDOPLASMIC RETICULUM IN PHENOBARBITAL INDUCTION

S. Orrenius, J. Ericsson, 1966, The Journal of cell biology.

Calcium ions and oxidative cell injury

S. Orrenius, P. Nicotera, G. Kass, 1992, Annals of neurology.

Multimeric alpha-lactalbumin from human milk induces apoptosis through a direct effect on cell nuclei.

B. Zhivotovsky, S. Orrenius, A. Hakansson, 1999, Experimental cell research.

The multiple roles of glutathione in drug metabolism

S. Orrenius, P. Moldéus, 1984 .

Visualization of the compartmentalization of glutathione and protein‐glutathione mixed disulfides in cultured cells

S. Orrenius, O. Ottersen, A. Holmgren, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

ON THE MECHANISM OF DRUG HYDROXYLATION IN RAT LIVER MICROSOMES

S. Orrenius, 1965, The Journal of cell biology.

Multiple Roles of the Calcium Ion in Cell Killing

S. Orrenius, P. Nicotera, 1994 .

Modifications of cell signalling in the cytotoxicity of metals.

S. Orrenius, M. Vahter, L. Manzo, 1991, Pharmacology & toxicology.

Short exposures to tunicamycin induce apoptosis in SV40-transformed but not in normal human fibroblasts.

O. Larsson, S. Orrenius, A. Dricu, 1996, Carcinogenesis.

ISOLATION AND PROPERTIES OF ROUGH AND SMOOTH VESICLES FROM RAT LIVER

S. Orrenius, G. Dallner, A. Bergstrand, 1963, The Journal of cell biology.

Mitochondrial Involvement in the Execution of Cell Death

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2012 .

An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2008, Cell Death and Differentiation.

Studies on mammary gland involution. IV. Histochemical and biochemical observations on alterations in lysosomes and lysosomal enzymes.

S. Orrenius, H. Helminen, J. Ericsson, 1968, Journal of ultrastructure research.

Ca2+-activated mechanisms in toxicity and programmed cell death

Dean P. Jones, S. Orrenius, P. Nicotera, 1988 .

Cytosolic‐free Ca2+ and cell killing in hepatoma 1c1c7 cells exposed to chemical anoxia

S. Orrenius, P. Nicotera, H. Thor, 1989, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Biochemical mechanisms of cytotoxicity

S. Orrenius, 1985 .

Inhibitors of arachidonic acid metabolism reduce DNA and nuclear fragmentation induced by TNF plus cycloheximide in U937 cells

S. Orrenius, P. Jakobsson, S. Feltenmark, 1997, Cell Death and Differentiation.

Involvement of cellular proteolytic machinery in apoptosis.

D. H. Burgess, B. Zhivotovsky, S. Orrenius, 1997, Biochemical and biophysical research communications.

Signal Transduction Pathways in Apoptosis

S. Orrenius, D. McConkey, 1996, Trends in cell biology.

The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.

S. Orrenius, P. Moldéus, M. Moore, 1985, The Journal of biological chemistry.

Pituitary involvement in the sexual differentiation and 3-methylcholanthrene induction of rat liver microsomal monooxygenases.

J. Gustafsson, S. Orrenius, M. Burke, 1978, Biochemical pharmacology.

Host biochemical defense mechanisms against prooxidants.

S. Orrenius, P. Moldéus, I. Cotgreave, 1988, Annual review of pharmacology and toxicology.

The mechanism of pentachlorobutadienyl-glutathione nephrotoxicity studied with isolated rat renal epithelial cells.

S. Orrenius, R. Gerdes, T. W. Jones, 1986, Archives of biochemistry and biophysics.

Genistein induces apoptosis in immature human thymocytes by inhibiting topoisomerase-II.

S. Orrenius, M. McCabe, 1993, Biochemical and biophysical research communications.

Hemoprotein quantitation in isolated hepatocytes.

S. Orrenius, H. S. Mason, D. P. Jones, 1979, Biochimica et biophysica acta.

Cytochrome P450 product complexes and glutathione consumption produced in isolated hepatocytes by norbenzphetamine and its N-oxidized congeners.

S. Orrenius, M. Hirata, B. Lindeke, 1979, Biochemical pharmacology.

Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex.

S. Orrenius, D. McConkey, P. Hartzell, 1989, Journal of immunology.

Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis.

S. Orrenius, S. Chow, I. Peters, 1995, Experimental cell research.

Role of Mitochondria in Neuronal Apoptosis Mitochondria in Neuronal Apoptosis

S. Orrenius, S. Ceccatelli, A. Gorman, 2018 .

Metabolism of hydrogen peroxide in isolated hepatocytes: relative contributions of catalase and glutathione peroxidase in decomposition of endogenously generated H2O2.

S. Orrenius, D. P. Jones, H. Thor, 1981, Archives of biochemistry and biophysics.

The role of calcium in the regulation of apoptosis.

S. Orrenius, D. McConkey, 1997, Biochemical and biophysical research communications.

Characterization of a rat lung microsomal fraction obtained by sepharose 2B ultrafiltration.

S. Orrenius, J. Capdevila, B. Jernström, 1975, Cancer research.

The isolation of rat intestinal microsomes with stable cytochrome P-450 and their metabolism of benzo(alpha) pyrene.

S. Orrenius, R. Grafström, P. Moldéus, 1976, Archives of biochemistry and biophysics.

Xenobiotic metabolism and enzyme induction in isolated rat intestinal microsomes.

S. Orrenius, R. Grafström, S. Stohs, 1976, Drug metabolism and disposition: the biological fate of chemicals.

Quantitation of hemoproteins in rat small intestinal mucosa with identification of mitochondrial cytochrome P-450.

S. Orrenius, R. Grafström, D. P. Jones, 1980, The Journal of biological chemistry.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) kills glucocorticoid-sensitive thymocytes in vivo.

S. Orrenius, D. McConkey, 1989, Biochemical and biophysical research communications.

On the role of thiol groups in the inhibition of liver microsomal Ca2+ sequestration by toxic agents.

S. Orrenius, G. Bellomo, H. Thor, 1985, Biochemical pharmacology.

Quinone toxicity in hepatocytes without oxidative stress.

S. Orrenius, P. O'Brien, G. Moore, 1986, Archives of biochemistry and biophysics.

Toxic injury to isolated hepatocytes is not dependent on extracellular calcium.

S. Orrenius, H. Thor, M. Smith, 1981, Science.

Benzo(α)pyrene metabolism by isolated rat intestinal epithelial cells

S. Orrenius, R. Grafström, S. Stohs, 1977 .

Xenobiotic metabolism by isolated rat small intestinal cells.

S. Orrenius, R. Grafström, P. Moldéus, 1979, Medical biology.

Effects of oxidative stress caused by hyperoxia and diquat. A study in isolated hepatocytes.

S. Orrenius, H. Thor, L. Rossi, 1986, Free radical research communications.

Calcium‐Dependent Cell Death Role of the Endonuclease, Protein Kinase C, and Chromatin Conformation

S. Orrenius, P. Nicotera, M. McCabe, 1992, Annals of the New York Academy of Sciences.

Effects of glutathione and chelating agents on copper-mediated DNA oxidation: pro-oxidant and antioxidant properties of glutathione.

S. Orrenius, P. Nicotera, M. Burkitt, 1993, Archives of biochemistry and biophysics.

Correlation between cytosolic Ca2+ concentration and cytotoxicity in hepatocytes exposed to oxidative stress.

S. Orrenius, P. Nicotera, D. McConkey, 1988, Toxicology.

Regulation of intracellular calcium compartmentation: studies with isolated hepatocytes and t-butyl hydroperoxide.

S. Orrenius, G. Bellomo, H. Thor, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Turnover and functions of glutathione studied with isolated hepatic and renal cells.

S. Orrenius, H. Thor, S. Jewell, 1983, Federation proceedings.

Ca2+-activated mechanisms in cell killing.

S. Orrenius, P. Nicotera, D. McConkey, 1989, Drug metabolism reviews.

The measurement of lipid peroxidation in isolated hepatocytes.

S. Orrenius, H. Thor, M. Smith, 1982, Biochemical pharmacology.

Radical scavenging compound J 811 inhibits hydrogen peroxide‐induced death of cerebellar granule cells

P. Riederer, B. Zhivotovsky, S. Orrenius, 1999, Journal of neuroscience research.

Ca2+ and Cell Death a

S. Orrenius, P. Nicotera, 1992, Annals of the New York Academy of Sciences.

Involvement of multiple proteases during Fas‐mediated apoptosis in T lymphocytes

S. Orrenius, J. Eriksson, T. Holmström, 1995, FEBS letters.

Processed caspase‐2 can induce mitochondria‐mediated apoptosis independently of its enzymatic activity

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2004, EMBO Reports.

Signalling and Chromatin Fragmentation in Thymocyte Apoptosis

S. Orrenius, P. Nicotera, D. McConkey, 1994, Immunological reviews.

Oxidative modification sensitizes mitochondrial apoptosis-inducing factor to calpain-mediated processing.

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2010, Free radical biology & medicine.

Role of Cell Death in Toxicology: Does It Matter How Cells Die?

S. Orrenius, 2019, Annual review of pharmacology and toxicology.

Targeting mitochondria by α-tocopheryl succinate kills neuroblastoma cells irrespective of MycN oncogene expression

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2012, Cellular and Molecular Life Sciences.

Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release.

V. Gogvadze, S. Orrenius, S. Kaufmann, 2002, Blood.

Calcium-activated DNA fragmentation in rat liver nuclei.

S. Orrenius, P. Nicotera, D. McConkey, 1989, The Journal of biological chemistry.

Alterations in Bcl‐2/Bax protein levels in platelets form part of an ionomycin‐induced process that resembles apoptosis

S. Orrenius, M. Aguilar-Santelises, D. Vanags, 1997, British journal of haematology.

Potentiation of oxidative cell injury in hepatocytes which have accumulated Ca2+.

S. Orrenius, H. Thor, P. Hartzell, 1984, The Journal of biological chemistry.

Effects of N-acetyl-L-cysteine on T-cell apoptosis are not mediated by increased cellular glutathione.

Dean P. Jones, S. Orrenius, D. P. Jones, 1995, Immunology letters.

Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes.

P. Rorsman, A. Hallberg, S. Orrenius, 1993, Science.

Chapter 6 – Toxicological Implications of Perturbation of Ca2+ Homeostasis in Hepatocytes

S. Orrenius, 1986 .

ATP stimulates the uptake of S‐dinitrophenylglutathione by rat liver plasma membrane vesicles

S. Orrenius, P. Nicotera, K. Hayashi, 1988, FEBS letters.

Paracetamol metabolism in the isolated perfused rat liver with further metabolism of a biliary paracetamol conjugate by the small intestine.

S. Orrenius, R. Grafström, P. Moldéus, 1979, Biochemical pharmacology.

Formation and metabolism of a glutathione-S-conjugate in isolated rat liver and kidney cells.

S. Orrenius, D. P. Jones, P. Moldéus, 1978, Biochemical and biophysical research communications.

Demonstration and partial characterization of glutathione disulfide-stimulated ATPase activity in the plasma membrane fraction from rat hepatocytes.

S. Orrenius, P. Nicotera, G. Bellomo, 1985, The Journal of biological chemistry.

Metabolism of glutathione and a glutathione conjugate by isolated kidney cells.

H. Jörnvall, S. Orrenius, D. P. Jones, 1979, The Journal of biological chemistry.

The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: role of intracellular calcium.

S. Orrenius, P. Nicotera, G. Kass, 1988, Archives of biochemistry and biophysics.

The role of intracellular oxidants in apoptosis.

S. Orrenius, A. Slater, C. Nobel, 1995, Biochimica et biophysica acta.

Interleukin 1 inhibits T cell receptor-mediated apoptosis in immature thymocytes.

S. Orrenius, D. McConkey, S. Chow, 1990, The Journal of biological chemistry.

Inhibition of ATP-dependent microsomal Ca2+ sequestration during oxidative stress and its prevention by glutathione.

S. Orrenius, D. P. Jones, H. Thor, 1983, The Journal of biological chemistry.

Increase in cytosolic Ca2+ concentration during t‐butyl hydroperoxide metabolism by isolated hepatocytes involves NADPH oxidation and mobilization of intracellular Ca2+ stores

S. Orrenius, G. Bellomo, H. Thor, 1984, FEBS letters.

Inhibition of hepatocyte plasma membrane Ca2+‐ATPase activity by menadione metabolism and its restoration by thiols

S. Orrenius, G. Bellomo, P. Nicotera, 1985, FEBS letters.

The consequences of lipid peroxidation in isolated hepatocytes.

S. Orrenius, J. Högberg, P. Moldéus, 1975, European journal of biochemistry.

Cytochrome P-450 in human fetal liver microsomes.

S. Orrenius, A. Rane, F. Sjöqvist, 1971, Chemico-biological interactions.

Modulation of Cell Death by Oxidants and Antioxidants

S. Orrenius, M. Hampton, 1998 .

Redox regulation of apoptotic cell death in the immune system.

S. Orrenius, M. Hampton, 1998, Toxicology letters.

Activation of hepatocyte protein kinase C by redox-cycling quinones.

S. Orrenius, G. Kass, S. Duddy, 1989, The Biochemical journal.

PHENOBARBITAL-INDUCED SYNTHESIS OF THE MICROSOMAL DRUG-METABOLIZING ENZYME SYSTEM AND ITS RELATIONSHIP TO THE PROLIFERATION OF ENDOPLASMIC MEMBRANES

S. Orrenius, L. Ernster, J. Ericsson, 1965, The Journal of cell biology.

CHAPTER 6 – Calcium-Modulated Cellular Effects of Oxidants

S. Orrenius, P. Nicotera, G. Kass, 1992 .

Cyclosporin A protects hepatocytes against prooxidant-induced cell killing. A study on the role of mitochondrial Ca2+ cycling in cytotoxicity.

S. Orrenius, G. Kass, M. J. Juedes, 1992, Biochemical pharmacology.

Role of calcium in toxic and programmed cell death.

S. Orrenius, P. Nicotera, D. McConkey, 1991, Advances in experimental medicine and biology.

Cytoskeletal alterations in human platelets exposed to oxidative stress are mediated by oxidative and Ca2+-dependent mechanisms.

S. Orrenius, G. Bellomo, M. Vairetti, 1989, Archives of biochemistry and biophysics.

Role of Calcium in Oxidative Cell Injury

S. Orrenius, P. Nicotera, D. McConkey, 1989 .

Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress.

S. Orrenius, P. Nicotera, D. McConkey, 1988, Toxicology letters.

On the role of calcium in chemical toxicity.

S. Orrenius, P. Nicotera, 1987, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

The role of calcium in the regulation of apoptosis

S. Orrenius, D. McConkey, 1996, Scanning microscopy.

Defects in the apoptotic machinery of cancer cells: role in drug resistance.

B. Zhivotovsky, S. Orrenius, 2003, Seminars in cancer biology.

Quinone toxicity in hepatocytes: studies on mitochondrial Ca2+ release induced by benzoquinone derivatives.

S. Orrenius, P. Nicotera, P. O'Brien, 1987, Archives of biochemistry and biophysics.

The inhibition of the mitochondrial NADH oxidase by alprenolol and the protective effect of cytochrome P-450.

S. Orrenius, H. Thor, R. Grundin, 2009, Acta pharmacologica et toxicologica.

Cellular defense mechanisms against toxic substances.

S. Orrenius, H. Thor, T. W. Jones, 1986, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

Drug Biotransformation and Drug Toxicity Studied with Intact Mammalian Cells

S. Orrenius, 1985 .

Intracellular redox changes during apoptosis.

S. Orrenius, D. J. van den Dobbelsteen, A. Slater, 1996, Cell death and differentiation.

The metabolism of benzo(alpha)pyrene in isolated rat liver cells.

S. Orrenius, J. Capdevila, P. Moldéus, 1975, Cancer research.

A comparative study on the effects of phenobarbital and 3,4-benzpyrene on the hydroxylating enzyme system of rat-liver microsomes.

S. Orrenius, H. Thor, Y. Gnosspelius, 1969, Chemico-biological interactions.

Enhancement of glucuronylating enzymes and mitochondrial oxidative enzymes in livers of rats treated with phenobarbital.

S. Orrenius, L. Ernster, P. Zeidenberg, 1967, Transactions of the New York Academy of Sciences.

Tributyltin increases cytosolic free Ca2+ concentration in thymocytes by mobilizing intracellular Ca2+, activating a Ca2+ entry pathway, and inhibiting Ca2+ efflux.

S. Orrenius, G. Kass, M. McCabe, 1992, Archives of biochemistry and biophysics.

The Role of Cytochrome P-450 in Microsomal Mixed Function Oxidation Reactions

S. Orrenius, R. Estabrook, J. Schenkman, 1968 .

2,5-Di-(tert-butyl)-1,4-benzohydroquinone rapidly elevates cytosolic Ca2+ concentration by mobilizing the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool.

S. Orrenius, G. Kass, S. Duddy, 1989, The Journal of biological chemistry.

Induction of DNA fragmentation in chronic B-lymphocytic leukemia cells.

S. Orrenius, D. McConkey, I. Eriksson, 1991, Journal of immunology.

Purines and their roles in apoptosis

S. Orrenius, G. Kass, S. Chow, 1997, Neuropharmacology.

Metabolic activation and hepatotoxicity. Effect of cysteine, N-acetylcysteine, and methionine on glutathione biosynthesis and bromobenzene toxicity in isolated rat hepatocytes.

S. Orrenius, P. Moldéus, H. Thor, 1979, Archives of biochemistry and biophysics.

Hydroperoxide-supported cytochrome P-450-linked fatty acid hydroxylation in liver microsomes.

S. Orrenius, A. Ellin, Å. Ellin, 1975 .

Glutathione S‐conjugates stimulate ATP hydrolysis in the plasma membrane fraction of rat hepatocytes

S. Orrenius, P. Nicotera, G. Bellomo, 1985, FEBS letters.

Alterations in thiol and calcium-ion homoeostasis during hydroperoxide and drug metabolism in hepatocytes.

S. Orrenius, G. Bellomo, H. Thor, 1984, Biochemical Society transactions.

Induction of apoptosis and caspase activation in cells obtained from familial haemophagocytic lymphohistiocytosis patients

S. Orrenius, B. Fadeel, J. Henter, 1999, British journal of haematology.

Ca2+ channel blockers verapamil and nifedipine inhibit apoptosis induced by 25-hydroxycholesterol in human aortic smooth muscle cells.

J. Thyberg, S. Orrenius, P. Berggren, 1997, Journal of lipid research.

Proteases in apoptosis

D. H. Burgess, B. Zhivotovsky, S. Orrenius, 1996, Experientia.

The role of proteolysis in T cell apoptosis triggered by chelation of intracellular Zn2+

D. H. Burgess, B. Zhivotovsky, S. Orrenius, 1997, Cell Death and Differentiation.

Oxidation of glutathione during hydroperoxide metabolism. A study using isolated hepatocytes and the glutathione reductase inhibitor 1,3-bis(2-chloroethyl)-1-nitrosourea.

S. Orrenius, P. Moldéus, L. Eklöw, 1984, European journal of biochemistry.

The presence of a monooxygenase system in human fetal liver microsomes.

S. Orrenius, A. Rane, F. Sjöqvist, 1970, Life sciences. Pt. 2: Biochemistry, general and molecular biology.

The cytoskeleton as a target in quinone toxicity.

S. Orrenius, G. Bellomo, W. Malorni, 1990, Free radical research communications.

Mechanisms of Oxidative Cell Damage

S. Orrenius, 1993 .

METABOLIC REGULATION IN OXIDATIVE STRESS

S. Orrenius, G. Bellomo, 1990 .

Role of thiols in protection against biological reactive intermediates.

S. Orrenius, P. Nicotera, 1986, Advances in experimental medicine and biology.

tert-Butylhydroperoxide-induced toxicity in isolated hepatocytes: contribution of thiol oxidation and lipid peroxidation.

D. D. Di Monte, S. Orrenius, G. Bellomo, 1986, Journal of biochemical toxicology.

Ca2+ homeostasis and cytotoxicity in isolated hepatocytes: studies with extracellular adenosine 5'-triphosphate.

S. Orrenius, P. Nicotera, G. Bellomo, 1986, Journal of biochemical toxicology.

The metabolism of menadione impairs the ability of rat liver mitochondria to take up and retain calcium.

S. Orrenius, G. Bellomo, S. Jewell, 1982, The Journal of biological chemistry.

Apoptosis: Cell death defined by caspase activation

Dean P. Jones, B. Zhivotovsky, S. Orrenius, 1999, Cell Death and Differentiation.

Metabolism of extracellular glutathione in rat small-intestinal mucosa.

S. Orrenius, R. Grafström, A. Stead, 1980, European journal of biochemistry.

BENZO (α) PYRENE METABOLISM BY MICROSOMES AND ISOLATED EPITHELIAL CELLS FROM RAT SMALL INTESTINE

S. Orrenius, R. Grafström, P. Moldéus, 1977 .

Signal transduction pathways in apoptosis.

S. Orrenius, D. McConkey, 1994, Stem cells.

Formation and Inactivation of Dna-Binding Metabolites of Benzo(a)Pyrene Studied with Isolated Cells and Subcellular Fractions

S. Orrenius, B. Jernström, S. Hesse, 1980 .

Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis.

S. Orrenius, E. Maellaro, J. Bustamante, 1995, The Biochemical journal.

Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts.

D. H. Burgess, B. Zhivotovsky, S. Orrenius, 1998, The Biochemical journal.

Phosphatidylserine exposure in Fas type I cells is mitochondria‐dependent

S. Orrenius, L. Nutt, B. Fadeel, 2003, FEBS letters.

Fas‐triggered phosphatidylserine exposure is modulated by intracellular ATP

V. Gogvadze, S. Orrenius, B. Fadeel, 2002, FEBS letters.

THE ROLE OF LIVER NUCLEI IN THE FORMATION OF DNA BINDING PRODUCTS FROM BENZO(a) PYRENE

S. Orrenius, B. Jernström, H. Vadi, 1977 .

Formation in isolated rat liver microsomes and nuclei of benzo(a)pyrene metabolites that bind to DNA.

S. Orrenius, B. Jernström, H. Vadi, 1976, Cancer research.

Role of sulfhydryl groups in benzoquinone-induced Ca2+ release by rat liver mitochondria.

S. Orrenius, P. O'Brien, M. Weis, 1988, Archives of biochemistry and biophysics.

On the relationship between Ca2+ efflux and membrane damage during t‐butylhydroperoxide metabolism by liver mitochondria

S. Orrenius, G. Bellomo, S. Jewell, 1983, FEBS letters.

Spermine prevents endonuclease activation and apoptosis in thymocytes.

S. Orrenius, B. Brüne, P. Nicotera, 1991, Experimental cell research.

ATP stimulates Ca2+ uptake and increases the free Ca2+ concentration in isolated rat liver nuclei.

S. Orrenius, P. Nicotera, D. McConkey, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Caspase-2 promotes cytoskeleton protein degradation during apoptotic cell death

B. Zhivotovsky, S. Orrenius, F. Ciccosanti, 2013, Cell Death and Disease.

Serine proteases and calpains fulfill important supporting roles in the apoptotic tragedy of the cellular opera

P. Vandenabeele, B. Zhivotovsky, S. Orrenius, 2005, Cell Death and Differentiation.

Regulation and Mechanisms of Apoptosis in T Lymphocytes

S. Orrenius, A. Slater, C. Nobel, 1997 .

Further studies on lipid-peroxide formation in isolated hepatocytes.

S. Orrenius, J. Högberg, P. O'Brien, 1975, European journal of biochemistry.

Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage

B. Zhivotovsky, S. Orrenius, H. Vakifahmetoglu, 2006, Oncogene.

Cellular events in Fas/APO-1-mediated apoptosis in JURKAT T lymphocytes.

S. Orrenius, J. Eriksson, T. Holmström, 1995, Experimental cell research.

Ten years of publication in cell death

D. Green, R. Knight, G. Melino, 2004, Cell Death and Differentiation.

Lamin and beta-tubulin fragmentation precede chromatin degradation in glutamate-induced neuronal apoptosis.

B. Zhivotovsky, S. Orrenius, P. Nicotera, 1996, Neuroreport.

Tumor Necrosis Factor a Induces Apoptosis in Mammary Adenocarcinoma Cells by an Increase in Intranuclear Free Ca2+ Concentration and DNA Fragmentation1

S. Orrenius, P. Nicotera, F. Taddei, 2006 .

Mitochondria, oxygen metabolism and the regulation of cell death

S. Orrenius, J. Chandra, 2002 .

Role of apoptosis in pancreatic beta-cell death in diabetes.

B. Zhivotovsky, S. Orrenius, P. Berggren, 2001, Diabetes.

Section 2 :-Cell Apoptosis Role of Apoptosis in Pancreatic-Cell Death in Diabetes

B. Zhivotovsky, S. Orrenius, P. Berggren, 2001 .

BCL-2 delay apoptosis and PARP cleavage induced by NO donors in GT1-7 cells.

S. Lipton, B. Zhivotovsky, S. Orrenius, 1996, Neuroreport.

Tumor necrosis factor alpha induces apoptosis in mammary adenocarcinoma cells by an increase in intranuclear free Ca2+ concentration and DNA fragmentation.

S. Orrenius, F. Taddei, G. Bellomo, 1992, Cancer research.

Calcium‐dependent DNA fragmentation in human synovial cells exposed to cold shock

S. Orrenius, D. McConkey, M. Vairetti, 1990, FEBS letters.

Citrate kills tumor cells through activation of apical caspases

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2012, Cellular and Molecular Life Sciences.

Lethal amphetamine intoxication

S. Orrenius, A. Maehly, 1970, Zeitschrift für Rechtsmedizin.

Bridge over troubled water: milk fat globule epidermal growth factor 8 promotes human monocyte-derived macrophage clearance of non-blebbing phosphatidylserine-positive target cells

S. Orrenius, B. Fadeel, M. Tanaka, 2007, Cell Death and Differentiation.

Antioxidant inhibition of thymocyte apoptosis by dihydrolipoic acid.

S. Orrenius, J. Bustamante, A. Slater, 1995, Free radical biology & medicine.

Drug metabolism in isolated rat liver cells.

S. Orrenius, P. Moldéus, H. Vadi, 1975, Advances in experimental medicine and biology.

Tributyltin-induced apoptosis requires glycolytic adenosine trisphosphate production.

S. Orrenius, P. Nicotera, M. Leist, 1999, Chemical research in toxicology.

Rapid turnover of endogenous endonuclease activity in thymocytes: effects of inhibitors of macromolecular synthesis.

S. Orrenius, D. McConkey, P. Hartzell, 1990, Archives of biochemistry and biophysics.

Characteristics of renal glutathione oxidase activity

S. Orrenius, K. Ormstad, T. Låstbom, 1981, FEBS letters.

Preparation and characteristics of isolated kidney cells.

S. Orrenius, D. P. Jones, K. Ormstad, 1981, Methods in enzymology.

Early work on apoptosis, an interview with Sten Orrenius

S. Orrenius, Sten Orrenius, 2006, Cell Death and Differentiation.

Analysis of Mitochondrial Dysfunction During Cell Death

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2004, Current protocols in toxicology.

Analysis of Mitochondrial Dysfunction During Cell Death

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2003, Current protocols in cell biology.

Agents that elevate cAMP stimulate DNA fragmentation in thymocytes.

S. Orrenius, D. McConkey, M. Jondal, 1990, Journal of immunology.

Lack of Ca2+ involvement in thymocyte apoptosis induced by chelation of intracellular Zn2+.

S. Orrenius, M. McCabe, S. Chow, 1995, Laboratory investigation; a journal of technical methods and pathology.

Chelation of intracellular zinc triggers apoptosis in mature thymocytes.

S. Orrenius, M. McCabe, S. Jiang, 1993, Laboratory investigation; a journal of technical methods and pathology.

Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration.

B. Zhivotovsky, S. Orrenius, M. Köhler, 1998, The Journal of biological chemistry.

Involvement of Ca2+ in the formation of high molecular weight DNA fragments in thymocyte apoptosis.

B. Zhivotovsky, S. Orrenius, P. Nicotera, 1994, Biochemical and Biophysical Research Communications - BBRC.

Comparison between the effects of the microsomal Ca(2+)-translocase inhibitors thapsigargin and 2,5-di-(t-butyl)-1,4-benzohydroquinone on cellular calcium fluxes.

S. Orrenius, G. Kass, J. Llopis, 1991, The Biochemical journal.

Mitochondrial cytochrome c release may occur by volume-dependent mechanisms not involving permeability transition.

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2004, The Biochemical journal.

A folding variant of human alpha-lactalbumin induces mitochondrial permeability transition in isolated mitochondria.

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2001, European journal of biochemistry.

The semiconductor elements arsenic and indium induce apoptosis in rat thymocytes.

B. Fowler, S. Orrenius, M. Vahter, 1997, Toxicology.

Apoptosis in neuronal cells: role of caspases.

S. Orrenius, S. Ceccatelli, A. Gorman, 1998, Neuroreport.

Eicosanoids released following inhibition of the endoplasmic reticulum Ca2+ pump stimulate Ca2+ efflux in the perfused rat liver.

S. Orrenius, G. Kass, G. Farrell, 1993, Biochemical pharmacology.

Cytochrome P 450K of rat kidney cortex microsomes: its involvement in fatty acid - and ( -1)-hydroxylation.

S. Orrenius, J. Schenkman, A. Ellin, 1972, Archives of biochemistry and biophysics.

NADPH-dependent reductase solubilized from microsomes by peroxidation and its activity.

S. Orrenius, J. Högberg, A. Kristoferson, 1974, Biochemical and biophysical research communications.

Adenosine inhibits protein synthesis in isolated rat hepatocytes. Evidence for a lack of involvement of intracellular calcium in the mechanism of inhibition.

S. Orrenius, G. Kass, P. Buc-Calderon, 1995, European Journal of Biochemistry.

Mechanism of allyl alcohol toxicity and protective effects of low-molecular-weight thiols studied with isolated rat hepatocytes.

S. Orrenius, D. Ross, Y. Ohno, 1985, Toxicology and applied pharmacology.

Alterations in canine liver cells induced by protein deficiency. Ultrastructural and biochemical observations.

S. Orrenius, I. Holm, J. Ericsson, 1966, Experimental and molecular pathology.

Formation of 50 kbp chromatin fragments in isolated liver nuclei is mediated by protease and endonuclease activation

B. Zhivotovsky, S. Orrenius, P. Nicotera, 1994, FEBS letters.

Role of Mitochondria in Neuronal Apoptosis

S. Orrenius, S. Ceccatelli, A. Gorman, 2000, Developmental Neuroscience.

Mechanisms of calcium-related cell death.

S. Orrenius, P. Nicotera, M. Ankarcrona, 1996, Advances in neurology.

Detection of pro‐caspase‐3 in cytosol and mitochondria of various tissues

B. Zhivotovsky, S. Orrenius, D. P. Jones, 1998, FEBS letters.

Analysis of mitochondrial dysfunction during cell death.

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2015, Methods in molecular biology.

Clinical perspectives of cell death: where we are and where to go…

B. Zhivotovsky, S. Orrenius, 2009, Apoptosis.

Caspases: their intracellular localization and translocation during apoptosis

Sten Orrenius, Boris Zhivotovsky, B. Zhivotovsky, 1999, Cell Death and Differentiation.

Metabolism of benzo[a]pyrene‐3,6‐quinone by isolated hepatocytes

S. Orrenius, J. Capdevila, Sten Orrenius, 1980, FEBS letters.

Co-receptor (CD4/CD8) engagement enhances CD3-induced apoptosis in thymocytes. Implications for negative selection.

S. Orrenius, D. McConkey, L. Fosdick, 1994, Journal of immunology.

Drug Metabolizing Enzymes: Genetics, Regulation and Toxicology

M. Ingelman-Sundberg, J. Gustafsson, S. Orrenius, 1990 .

An inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in liver nuclei.

S. Orrenius, P. Nicotera, P. Berggren, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Corrections - The Nature of the Reverse Type I (Modified Type II) Spectral Change in Liver Microsomes

S. Orrenius, D. L. Cinti, J. Schenkman, 1973 .

Newer aspects of substrate binding to cytochrome P-450.

S. Orrenius, D. L. Cinti, J. Schenkman, 1973, Drug metabolism and disposition: the biological fate of chemicals.

Assessment of Apoptosis and Necrosis by DNA Fragmentation and Morphological Criteria

S. Orrenius, B. Zhivotosky, Sten Orrenius, 2001, Current protocols in cell biology.

Determination of Apoptosis and Necrosis

B. Zhivotovsky, S. Orrenius, Afshin Samali, 1999, Current protocols in toxicology.

Quantitation of DNA fragmentation using fiberglass filters.

S. Orrenius, D. McConkey, S. Chow, 1989, Analytical biochemistry.

Effects of different cell constituents on metabolic activation and binding of benzo(a)pyrene to purified and nuclear DNA.

S. Orrenius, B. Jernström, T. Guenthner, 1979, Biochemical and biophysical research communications.

Calcineurin and mitochondrial function in glutamate‐induced neuronal cell death

S. Orrenius, P. Nicotera, M. Ankarcrona, 1996, FEBS letters.

A comparative study of drug metabolism in the isolated perfused liver and in vivo in rats.

S. Orrenius, D. Azarnoff, B. Alexanderson, 1970, European journal of pharmacology.

The effect of ethanol on drug oxidations in vitro and the significance of ethanol-cytochrome P-450 interaction.

S. Orrenius, D. L. Cinti, R. Grundin, 1973, The Biochemical journal.

Uptake and metabolism of leukotriene C3 by isolated rat organs and cells.

S. Orrenius, L. Orning, K. Ormstad, 1982, Biochemical and Biophysical Research Communications - BBRC.

Receptor-operated calcium influx in rat hepatocytes. Identification and characterization using manganese.

S. Orrenius, G. Kass, J. Llopis, 1990, The Journal of biological chemistry.

Organotin-induced caspase activation and apoptosis in human peripheral blood lymphocytes.

S. Orrenius, I. Cotgreave, D. Gigliotti, 2001, Chemical research in toxicology.

FURTHER STUDIES ON THE INDUCTION OF THE DRUG-HYDROXYLATING ENZYME SYSTEM OF LIVER MICROSOMES

S. Orrenius, 1965, The Journal of cell biology.

A study of the interaction of a series of substituted barbituric acids with the hepatic microsomal monooxygenase.

S. Orrenius, J. Schenkman, L. Ernster, 1972, Archives of biochemistry and biophysics.

Deletion and depletion: the involvement of viruses and environmental factors in T-lymphocyte apoptosis.

S. Orrenius, M. McCabe, 1992, Laboratory investigation; a journal of technical methods and pathology.

Characteristics of glutathione biosynthesis by freshly isolated rat kidney cells.

S. Orrenius, D. P. Jones, K. Ormstad, 1980, The Journal of biological chemistry.

Phenobarbital-induced synthesis of the oxidative demethylating enzymes of rat liver microsomes.

S. Orrenius, L. Ernster, 1964, Biochemical and biophysical research communications.

Phosphatidylserine externalization in cardiolipin-deficient cells.

S. Orrenius, B. Fadeel, M. Enoksson, 2004, Blood.

The cytochrome P-450-containing mono-oxygenase system of rat kidney cortex microsomes.

S. Orrenius, R. Estabrook, D. L. Cinti, 1973, Drug metabolism and disposition: the biological fate of chemicals.

Detection and measurement of drug-induced oxygen radical formation.

S. Orrenius, H. Thor, M. Smith, 1984, Methods in enzymology.

Metabolism of benzo(a)pyrene with isolated hepatocytes and the formation and degradation of DNA-binding derivatives.

S. Orrenius, B. Jernström, M. Burke, 1977, The Journal of biological chemistry.

Pharmacokinetics and mechanism of action of detoxifying low-molecular-weight thiols

S. Orrenius, N. Brock, J. Pohl, 2004, Journal of Cancer Research and Clinical Oncology.

Interaction of menadione (2-methyl-1,4-naphthoquinone) with glutathione.

S. Orrenius, D. Ross, P. Moldéus, 1985, Chemico-biological interactions.

The mechanism of bromobenzene-induced cytotoxicity studied with isolated hepatocytes

S. Orrenius, H. Thor, 1980, Archives of Toxicology.

Role of nucleases in apoptosis.

B. Zhivotovsky, S. Orrenius, P. Nicotera, 1994, International archives of allergy and immunology.

Conversion of agroclavine by mammalian cytochrome P-450.

S. Orrenius, I. Jansson, B. J. Wilson, 1971, Biochimica et biophysica acta.

The Warburg effect and mitochondrial stability in cancer cells.

Sten Orrenius, Boris Zhivotovsky, B. Zhivotovsky, 2010, Molecular aspects of medicine.

Inhibition of binding of benzo(a)pyrene metabolites to nuclear DNA by glutathione and glutathione S-transferase B.

S. Orrenius, B. Ketterer, L. Christodoulides, 1980, Biochemical and biophysical research communications.

Triggering and modulation of apoptosis by oxidative stress.

S. Orrenius, Afshin Samali, J. Chandra, 2000, Free radical biology & medicine.

Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis

S. Orrenius, M. Hampton, 1997, FEBS letters.

THE METABOLISM OF POLYCYCLIC HYDROCARBONS AND ITS RELATIONSHIP TO CHEMICAL CARCINOGENESIS

S. Orrenius, J. Capdevila, J. Depierre, 1976 .

Isolation and use of liver cells.

S. Orrenius, J. Högberg, P. Moldéus, 1978, Methods in enzymology.

Calcium-mediated mechanisms in chemically induced cell death.

S. Orrenius, P. Nicotera, G. Bellomo, 1992, Annual review of pharmacology and toxicology.

On the mechanisms of glutathione depletion in hepatocytes exposed to morphine and ethylmorphine.

S. Orrenius, P. Moldéus, L. Eklöw-Låstbom, 1986, Toxicology.

PDFlib PLOP: PDF Linearization, Optimization, Protection Page inserted by evaluation version

S. Orrenius, A. Linnane, 2001 .

Two separate plasma membrane Ca2+ carriers participate in receptor-mediated Ca2+ influx in rat hepatocytes.

S. Orrenius, P. Berggren, G. Kass, 1994, Biochimica et biophysica acta.

Calcium ions in necrotic and apoptotic cell death

S. Orrenius, P. Nicotera, 1996 .

5 – Quinone-Induced Oxidative Injury to Cells and Tissues

S. Orrenius, Martyn T. Smith, H. Thor, 1985 .

Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins

S. Orrenius, C. Holmberg, L. Sistonen, 1999, FEBS letters.

Drug-stimulated H2O2 formation in hepatocytes. Possible toxicological implications.

S. Orrenius, P. Moldéus, H. Thor, 1981, Advances in experimental medicine and biology.

A comparative study of apoptosis and necrosis in HepG2 cells: oxidant-induced caspase inactivation leads to necrosis.

B. Zhivotovsky, S. Orrenius, Afshin Samali, 1999, Biochemical and biophysical research communications.

Apoptosis--molecular mechanisms and biomedical implications.

B. Zhivotovsky, S. Orrenius, D. McConkey, 1996, Molecular aspects of medicine.

Mitochondria as targets for chemotherapy

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2009, Apoptosis.

Cytochrome c release from mitochondria proceeds by a two-step process

Sten Orrenius, Boris Zhivotovsky, Martin Ott, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Molecular Mechanisms of Apoptosis Induced by Cytotoxic Chemicals

Sten Orrenius, S. Orrenius, John D. Robertson, 2000, Critical reviews in toxicology.

Effects ofrypsin on the electron transport systems of liver microsomes.

S. Orrenius, L. Ernster, A. Berg, 1969, European journal of biochemistry.

Fatty acid interaction with the hydroxylating enzyme system of rat liver microsomes.

S. Orrenius, H. Thor, 1969, European journal of biochemistry.

On the fatty acid and hydrocarbon hydroxylation in rat liver microsomes.

S. Orrenius, L. Ernster, M. Das, 1968, European journal of biochemistry.

Fatty acid hydroxylation in rat kidney cortex microsomes

S. Orrenius, A. Ellin, Å. Ellin, 1975, Molecular and Cellular Biochemistry.

Isolation and comparison of endoplasmic reticulum membranes and their mixed function oxidase activities from mammalian extrahepatic tissues.

S. Orrenius, M. Burke, 1979, Pharmacology & therapeutics.

Influence of inducers and inhibitors on the hydroxylation pattern of n‐hexane in rat liver microsomes

S. Orrenius, V. Ullrich, U. Frommer, 1974, FEBS letters.

6 – MICROSOMAL CYTOCHROME P-450-LINKED MONOOXYGENASE SYSTEMS IN MAMMALIAN TISSUES

S. Orrenius, L. Ernster, 1974 .

Cytochrome P-450K of rat kidney cortex microsomes: further studies on its interaction with fatty acids.

C. Swahn, S. Orrenius, A. Pilotti, 1973, Archives of biochemistry and biophysics.

The monooxygenation of N-heptane by rat liver microsomes.

S. Orrenius, V. Ullrich, U. Frommer, 1972, Biochimica et biophysica acta.

The role of calcium in the regulation of apoptosis.

S. Orrenius, D. McConkey, S Orrenius, 1996, Journal of leukocyte biology.

Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis.

S. Orrenius, G. Bellomo, H. Thor, 1982, Science.

Cellular signalling in programmed cell death (apoptosis).

S. Orrenius, D. McConkey, S Orrenius, 1990, Immunology today.

ENZYME-MEMBRANE RELATIONSHIP IN PHENOBARBITAL INDUCTION OF SYNTHESIS OF DRUG-METABOLIZING ENZYME SYSTEM AND PROLIFERATION OF ENDOPLASMIC MEMBRANES

S. Orrenius, J. Ericsson, 1966, The Journal of cell biology.

Inhibition of the TPNH-linked lipid peroxidation of liver microsomes by drugs undergoing oxidative demethylation.

S. Orrenius, G. Dallner, L. Ernster, 1964, Biochemical and biophysical research communications.

The role of lipid peroxidation in the toxicity of foreign compounds to liver cells.

S. Orrenius, M T Smith, S Orrenius, 1983, Biochemical pharmacology.

Role of Ca2+ in toxic cell killing.

S. Orrenius, P. Nicotera, D. McConkey, 1989, Trends in pharmacological sciences.

Lipid peroxidation in isolated hepatocytes.

S. Orrenius, J. Högberg, R. Larson, 1975, European journal of biochemistry.

Drugs and fetal metabolism

S. Orrenius, A. Rane, Folke Sίöqvist, 1973, Clinical pharmacology and therapeutics.

The nature of the reverse type I (modified type II) spectral change in liver microsomes.

S. Orrenius, D. L. Cinti, J. Schenkman, 1972, Biochemistry.

Characteristics of guinea pig liver and adrenal monooxygenase systems.

S. Orrenius, D. Kupfer, 1970, Molecular pharmacology.

Substrate binding to cytochrome P‐450 of liver and adrenal microsomes

S. Orrenius, L. Ernster, D. Kupfer, 1970, FEBS letters.

Substrate-induced synthesis of the hydroxylating enzyme system of liver microsomes.

S. Orrenius, L. Ernster, 1965, Federation proceedings.

The possible role of cytochrome P-450 in the liver "first pass elimination" of a beta-receptor blocking drug.

S. Orrenius, P. Moldéus, C. von Bahr, 2009, Acta Pharmacologica et Toxicologica.

A study of drug metabolism linked to cytochrome P-450 in isolated rat-liver cells.

S. Orrenius, P. Moldéus, R. Grundin, 1974, European journal of biochemistry.

Molecular aspects of drug metabolism.

S. Orrenius, 2009, Acta pharmacologica et toxicologica.

The significance of drug-induced spectral changes in liver microsomal fraction.

S. Orrenius, J. Schenkman, C. von Bahr, 1971, The Biochemical journal.

SUBSTRATE INTERACTION WITH MICROSOMAL CYTOCHROME P-450

S. Orrenius, L. Ernster, C. Bahr, 1972 .

Spectral studies on the interaction of imipramine and some of its oxidized metabolites with rat liver microsomes.

S. Orrenius, C. von Bahr, 1971, Xenobiotica; the fate of foreign compounds in biological systems.

Interaction of drugs, steroids and fatty acids with liver-microsomal cytochrome P-450.

S. Orrenius, D. Kupfer, 1970, European journal of biochemistry.

A study of the modified type II spectral change produced by the interaction of agroclavine with cytochrome P-450.

S. Orrenius, S Orrenius, B J Wilson, 1972, Biochimica et biophysica acta.

Mechanism of inhibition of microsomal mixed-function oxidation by the gut-contents inhibitor of the southern armyworm (Prodenia eridania).

S. Orrenius, P. Moldéus, R. Krieger, 1971, The Biochemical journal.

Effect of phenobarbital and 3,4-benzpyrene treatment of rats on the microsomal binding and hydroxylation of nortriptyline and desmethyl-imipramine: evidence for qualitative changes in cytochrome P-450-ligand interaction following phenobarbital pretreatment.

S. Orrenius, J. Schenkman, C. von Bahr, 1972, Xenobiotica; the fate of foreign compounds in biological systems.

2,3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation.

S. Orrenius, D. McConkey, H. Håkansson, 1988, Science.

Calcium signaling and cytotoxicity.

S. Orrenius, G. Kass, S Orrenius, 1999, Environmental health perspectives.

INCREASE IN LEVELS OF GLUCURONYLATING ENZYMES AND ASSOCIATED RISE IN ACTIVITIES OF MITOCHONDRIAL OXIDATIVE ENZYMES UPON PHENOBARBITAL ADMINISTRATION IN THE RAT

S. Orrenius, L. Ernster, P. Zeidenberg, 1967, The Journal of cell biology.

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.

S. Orrenius, Martyn T. Smith, G. Bellomo, 1982, The Journal of biological chemistry.

The TPNH-dependent oxidation of luminol catalyzed by rat liver microsomes☆

S. Orrenius, L. Ernster, R. Nilsson, 1964 .

Thiol modification and cell signalling in chemical toxicity.

S. Orrenius, P. Nicotera, L. Manzo, 1992, Toxicology letters.

The role of calcium in apoptosis.

S. Orrenius, P. Nicotera, P Nicotera, 1998, Cell calcium.

Partial characterization of a glutathione oxidase present in rat kidney plasma membrane fraction.

S. Orrenius, P. Moldéus, K. Ormstad, 1979, Biochemical and biophysical research communications.

Cytochrome P-450-product complexes produced by amphetamine derivatives: a comparative study with isolated liver microsomes and hepatocytes.

S. Orrenius, J. Högberg, H. Thor, 2009, Acta pharmacologica et toxicologica.

Fluorescence study of DNA-binding metabolites of benzo(a)pyrene formed in hepatocytes isolated from 3-methylcholanthrene-treated rats.

S. Orrenius, A. Gräslund, B. Jernström, 1978, Cancer research.

Fluorescence Study of DMA-binding Metabolites of Benzo(a)pyrene Formed in Hepatocytes Isolated from 3-Methylcholanthrene-treated Rats1

S. Orrenius, A. Ehrenberg, O. Undeman, 2006 .

Formation of DAN-binding products from isolated benzo[a]pyrene metabolites in rat liver nuclei

S. Orrenius, B. Jernström, H. Vadi, 1978 .

BIOTRANSFORMATION OF BENZO(a)PYRENE TO DNA-BINDING PRODUCTS BY ISOLATED HEPATOCYTES

S. Orrenius, B. Jernström, L. Dock, 1980 .

The renal thiol (glutathione) oxidase. Subcellular localization and properties.

S. Orrenius, L. Lash, D. Jones, 1984, Biochimica et biophysica acta.

The localization of renal glutathione oxidase activity studied in the isolated, perfused rat kidney.

S. Orrenius, K. Ormstad, 1980, Biochemical and biophysical research communications.

The role of oxidative processes in the cytotoxicity of substituted 1,4-naphthoquinones in isolated hepatocytes.

S. Orrenius, D. Ross, M. Sandy, 1986, Archives of biochemistry and biophysics.

Role of mitochondria in toxic oxidative stress.

Catherine B. Chan, S. Orrenius, B. Van Houten, 2005, Molecular interventions.

Microsomal lipid peroxidation.

S. Orrenius, L. Ernster, K. Nordenbrand, 1968, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

Cytotoxic and genotoxic effects of styrene-7,8-oxide in neuroadrenergic Pc 12 cells.

S. Orrenius, P. Nicotera, L. Costa, 1992, Carcinogenesis.

Proteases in Fas‐mediated apoptosis

D. H. Burgess, B. Zhivotovsky, S. Orrenius, 1997 .

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration.

S. Orrenius, P. Nicotera, D. McConkey, 1989, Archives of biochemistry and biophysics.

2,5‐Di(tert‐butyl)‐1,4‐benzohydroquinone — a novel inhibitor of liver microsomal Ca2+ sequestration

S. Orrenius, D. McConkey, G. Kass, 1987, FEBS letters.

Division of Biochemistry Department of Medical Biochemistry and Biophysics Karolinska Institutet, Stockholm, Sweden

S. Orrenius, Elias S. J. Arnér, S. Prast-Nielsen, 2009 .

Targeting hepatoma using nitric oxide donor strategies.

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2013, Antioxidants & redox signaling.

Mitochondria as targets for cancer chemotherapy.

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2009, Seminars in cancer biology.

The formation of both a mono- and a bis-substituted glutathione conjugate of hexachlorobutadiene by isolated hepatocytes and following in vivo administration to the rat.

S. Orrenius, R. Gerdes, K. Ormstad, 1985, Chemico-biological interactions.

Interaction between liver microsomes and compounds capable of undergoing enzymic hydroxylation.

S. Orrenius, L. Ernster, 1967, Life sciences.

Formation and efflux of glutathione disulfide studied in isolated rat hepatocytes

S. Orrenius, L. Eklöw, H. Thor, 1981, FEBS letters.

Accumulation of Ca2+ induced by cytotoxic levels of menadione in the isolated, perfused rat liver.

S. Orrenius, H. Mehendale, S. Svensson, 1985, European journal of biochemistry.

THE MECHANISM OF CYTOCHROME P-450-MEDIATED CYTOTOXICITY STUDIED WITH ISOLATED HEPATOCYTES EXPOSED TO BROMOBENZENE

S. Orrenius, H. Thor, S. Thorold, 1980 .

S04-4Mitochondrial involvement in cell death

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2012 .

Calcium and cell death mechanisms: a perspective from the cell death community.

Sten Orrenius, Boris Zhivotovsky, B. Zhivotovsky, 2011, Cell calcium.

Cell death mechanisms and their implications in toxicology.

B. Zhivotovsky, S. Orrenius, P. Nicotera, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Mitochondrial oxidative stress: implications for cell death.

Sten Orrenius, Boris Zhivotovsky, B. Zhivotovsky, 2007, Annual review of pharmacology and toxicology.

Reactive Oxygen Species in Mitochondria-Mediated Cell Death

S. Orrenius, 2007, Drug metabolism reviews.

Mitochondrial regulation of apoptotic cell death.

V. Gogvadze, S. Orrenius, 2006, Chemico-biological interactions.

Multiple pathways of cytochrome c release from mitochondria in apoptosis.

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2006, Biochimica et biophysica acta.

Autophagy in toxicology: cause or consequence?

B. Zhivotovsky, S. Orrenius, V. Kaminskyy, 2013, Annual review of pharmacology and toxicology.

Cell cycle and cell death in disease: past, present and future

B. Zhivotovsky, S. Orrenius, B Zhivotovsky, 2010, Journal of internal medicine.

Release of Ca2+ from the endoplasmic reticulum is not the mechanism for bile acid-induced cholestasis and hepatotoxicity in the intact rat liver.

S. Orrenius, G. Kass, G. Farrell, 1990, The Journal of clinical investigation.

Apoptosis: a basic biological phenomenon with wide‐ranging implications in human disease

S. Orrenius, B. Fadeel, 2005, Journal of internal medicine.

Human skeletal muscle cytosols are refractory to cytochrome c-dependent activation of type-II caspases and lack APAF-1

D. H. Burgess, S. Orrenius, I. Cotgreave, 1999, Cell Death and Differentiation.

Biological reactive intermediates and mechanisms of cell death.

V. Gogvadze, S. Orrenius, J. Chandra, 2001, Advances in experimental medicine and biology.

Cytochrome c release and caspase activation in hydrogen peroxide‐ and tributyltin‐induced apoptosis

Dean P. Jones, S. Orrenius, M. Hampton, 1998, FEBS letters.

Suppression of Fas/APO-1-mediated apoptosis by mitogen-activated kinase signaling.

S. Orrenius, J. Eriksson, L. Sistonen, 1998, Journal of immunology.

Protease Involvement in Fodrin Cleavage and Phosphatidylserine Exposure in Apoptosis*

D. H. Burgess, S. Orrenius, M. I. Pörn-Ares, 1996, The Journal of Biological Chemistry.

Rapid microfilament reorganization induced in isolated rat hepatocytes by microcystin-LR, a cyclic peptide toxin.

S. Orrenius, P. Nicotera, J. Eriksson, 1989, Experimental cell research.

HAMLET triggers apoptosis but tumor cell death is independent of caspases, Bcl-2 and p53

S. Orrenius, G. Selivanova, C. Svanborg, 2006, Apoptosis.

Caspase-2 Acts Upstream of Mitochondria to Promote Cytochromec Release during Etoposide-induced Apoptosis*

Sten Orrenius, Boris Zhivotovsky, B. Zhivotovsky, 2002, The Journal of Biological Chemistry.

Current Concepts in Cell Toxicity

B. Zhivotovsky, S. Orrenius, Afshin Samali, 1999, Current protocols in toxicology.

Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli

S. Orrenius, Afshin Samali, E. Peterson, 2001, Cell stress & chaperones.

Distinct Pathways for Stimulation of Cytochrome cRelease by Etoposide*

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2000, The Journal of Biological Chemistry.

The most unkindest cut of all: on the multiple roles of mammalian caspases*

B. Zhivotovsky, S. Orrenius, B. Fadeel, 2000, Leukemia.

Dexamethasone pre-treatment interferes with apoptotic death in glioma cells

S. Orrenius, S. Ceccatelli, A. Gorman, 2000, Neuroscience.

All along the watchtower: on the regulation of apoptosis regulators

B. Zhivotovsky, S. Orrenius, B. Fadeel, 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cleavage of Bcl-2 is an early event in chemotherapy-induced apoptosis of human myeloid leukemia cells

B. Zhivotovsky, S. Orrenius, B. Fadeel, 1999, Leukemia.

Presence of a pre‐apoptotic complex of pro‐caspase‐3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells

B. Zhivotovsky, S. Orrenius, D. P. Jones, 1999, The EMBO journal.

Cytochrome c release and caspase‐3 activation during colchicine‐induced apoptosis of cerebellar granule cells

B. Zhivotovsky, S. Orrenius, S. Ceccatelli, 1999, The European journal of neuroscience.

Redox Regulation of the Caspases during Apoptosis a

S. Orrenius, B. Fadeel, M. Hampton, 1998, Annals of the New York Academy of Sciences.

Calcium signalling and the regulation of apoptosis.

S. Orrenius, M. I. Pörn-Ares, M. Ares, 1998, Toxicology in vitro : an international journal published in association with BIBRA.

Apoptosis induced by microinjection of cytochrome c is caspase-dependent and is inhibited by Bcl-2

B. Zhivotovsky, S. Orrenius, S. Døskeland, 1998, Cell Death and Differentiation.

Back to the future: The role of cytochrome c in cell death

B. Zhivotovsky, S. Orrenius, K. P. Hanson, 1998, Cell Death and Differentiation.

Mitochondria as the focus of apoptosis research

D. H. Burgess, B. Zhivotovsky, S. Orrenius, 1997, Cell Death and Differentiation.

Induction of apoptosis and potentiation of TNF- and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609.

S. Orrenius, M. I. Pörn-Ares, J. Slotte, 1997, Experimental cell research.

Mitochondrial targeting of tBid/Bax: a role for the TOM complex?

B. Zhivotovsky, S. Orrenius, M. Ott, 2009, Cell Death and Differentiation.

Caspase involvement in the induction of apoptosis by the environmental toxicants tributyltin and triphenyltin.

S. Orrenius, M. Hampton, H. Stridh, 1999, Toxicology and applied pharmacology.

The Warburg Effect returns to the cancer stage.

B. Zhivotovsky, S. Orrenius, 2009, Seminars in cancer biology.

The cardiolipin-cytochrome c interaction and the mitochondrial regulation of apoptosis.

S. Orrenius, S. Iverson, 2004, Archives of biochemistry and biophysics.

Current Concepts in Cell Death

B. Zhivotovsky, S. Orrenius, 2001, Current protocols in cell biology.

Signalling mechanisms and oxidative stress in apoptosis.

S. Orrenius, D. J. van den Dobbelsteen, A. Slater, 1995, Toxicology letters.

Oxidative stress and apoptosis

S. Orrenius, A. Slater, 1995 .

Calcium‐activated DNA fragmentation kills immature thymocytes

S. Orrenius, P. Nicotera, D. McConkey, 1989, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cytochrome c Release Occurs via Ca2+-dependent and Ca2+-independent Mechanisms That Are Regulated by Bax*

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2001, The Journal of Biological Chemistry.

Evaluation of caspase activity in apoptotic cells.

B. Zhivotovsky, S. Orrenius, C. Köhler, 2002, Journal of immunological methods.

Comparative light and electron microscopic observations of the cytoplasmic matrix in renal carcinomas

S. Orrenius, J. Ericsson, R. Seljelid, 1966, Virchows Archiv für pathologische Anatomie und Physiologie und für klinische Medizin.

Overexpression of glutaredoxin 2 attenuates apoptosis by preventing cytochrome c release.

S. Orrenius, A. Holmgren, C. Lillig, 2005, Biochemical and biophysical research communications.

Arsenic stimulates release of cytochrome c from isolated mitochondria via induction of mitochondrial permeability transition.

V. Gogvadze, S. Orrenius, L. Nutt, 2005, Toxicology and applied pharmacology.

Injected cytochrome c induces apoptosis

Sten Orrenius, Boris Zhivotovsky, B. Zhivotovsky, 1998, Nature.

Apoptosis induced by a human milk protein.

B. Zhivotovsky, S. Orrenius, A. Hakansson, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Cytoskeletal Breakdown and Apoptosis Elicited by NO Donors in Cerebellar Granule Cells Require NMDA Receptor Activation

S. Lipton, B. Zhivotovsky, S. Orrenius, 1996, Journal of neurochemistry.

Carcinogenesis and apoptosis: paradigms and paradoxes.

B. Zhivotovsky, S. Orrenius, 2006, Carcinogenesis.

Outer mitochondrial membrane permeabilization: an open-and-shut case?

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2003, Cell Death and Differentiation.

The Potential Role of Apoptosis in Human Disease

B. Zhivotovsky, S. Orrenius, B. Fadeel, 2000, Medical Principles and Practice.

Tumor radiosensitivity and apoptosis.

B. Joseph, B. Zhivotovsky, S. Orrenius, 1999, Experimental cell research.

Cell death mechanisms: cross-talk and role in disease.

B. Zhivotovsky, S. Orrenius, 2010, Experimental cell research.

Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression.

S. Orrenius, B. Fadeel, Afshin Samali, 1999, Biochemical and biophysical research communications.

Apoptosis: molecular mechanisms and implications for human disease

S. Orrenius, S Orrenius, 1995, Journal of internal medicine.

Cyclic AMP potentiates glucocorticoid‐induced endogenous endonuclease activation in thymocytes 1

S. Orrenius, D. McConkey, S. Okret, 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[Apoptosis required for maintenance of homeostasis: familial hemophagocytic lymphohistiocytosis caused by too little cell death].

S. Orrenius, B. Fadeel, J. Henter, 2000, Lakartidningen.

Plasma membrane sequestration of apoptotic protease-activating factor-1 in human B-lymphoma cells: a novel mechanism of chemoresistance.

S. Orrenius, B. Fadeel, S. Pervaiz, 2005, Blood.

Neural stem cells and cell death.

S. Orrenius, C. Tamm, S. Ceccatelli, 2003, Toxicology letters.

Cell death in adult neural stem cells

B. Zhivotovsky, S. Orrenius, J. Frisén, 2002, Cell Death and Differentiation.

Neuronal necrosis and apoptosis: two distinct events induced by exposure to glutamate or oxidative stress.

S. Lipton, S. Orrenius, P. Nicotera, 1997, Advances in neurology.

In vitro studies of mechanisms of cytotoxicity.

S. Orrenius, H. Thor, T. Jones, 1986, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

FACTORS ALTERING THE RATE OF ALCOHOL METABOLISM IN HEPATOCYTES

S. Orrenius, M. Schulman, B. Andersson, 1977 .

Use of isolated kidney cells for study of drug metabolism.

Dean P. Jones, S. Orrenius, D. P. Jones, 1979, Biochemical pharmacology.

THE PHYSIOLOGICAL IMPLICATIONS OF DRUG OXIDATIONS TO THE CELL

S. Orrenius, J. Högberg, P. Moldéus, 1977 .

Dithiocarbamates and the redox regulation of cell death.

S. Orrenius, M. Burkitt, D. J. van den Dobbelsteen, 1996, Biochemical Society transactions.

Rapid cytoskeleton modification in thymocytes induced by the immunotoxicant tributyltin.

S. Orrenius, S. Chow, 1994, Toxicology and applied pharmacology.

Involvement of caspases in neutrophil apoptosis: regulation by reactive oxygen species.

S. Orrenius, B. Fadeel, M. Hampton, 1998, Blood.

Mitochondrial regulation of cell death: processing of apoptosis-inducing factor (AIF).

B. Zhivotovsky, S. Orrenius, E. Norberg, 2010, Biochemical and biophysical research communications.

Nuclear calcium transport and the role of calcium in apoptosis.

B. Zhivotovsky, S. Orrenius, P. Nicotera, 1994, Cell calcium.

Review: nuclear events in apoptosis.

B. Zhivotovsky, S. Orrenius, B Zhivotovsky, 2000, Journal of structural biology.

Isolation of rat liver microsomes by gel filtration.

S. Orrenius, O. Tangen, J. Jonsson, 1973, Analytical biochemistry.

Targeting mitochondria by α-tocopheryl succinate kills neuroblastoma cells irrespective of MycN oncogene expression

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2012, Cellular and Molecular Life Sciences.

2 – Molecular Mechanisms of Toxic Cell Death: An Overview

S. Orrenius, P. Nicotera, 1994 .

Cytochrome P-450-linked activation of 3-hydroxybenzo(a)pyrene

S. Orrenius, J. Capdevila, B. Jernström, 1975 .

Reactive oxygen species generated in different compartments induce cell death, survival, or senescence.

Sten Orrenius, Boris Zhivotovsky, B. Zhivotovsky, 2013, Free radical biology & medicine.

Cardiolipin Is Not Required for Bax-mediated Cytochrome c Release from Yeast Mitochondria*

V. Gogvadze, S. Orrenius, S. Iverson, 2004, Journal of Biological Chemistry.

Induction of DNA damage by menadione (2-methyl-1,4-naphthoquinone) in primary cultures of rat hepatocytes.

S. Orrenius, M. Nordenskjöld, B. Jernström, 1984, Biochemical pharmacology.

Pharmacokinetics and metabolism of sodium 2-mercaptoethanesulfonate in the rat.

S. Orrenius, N. Brock, J. Pohl, 1983, Cancer research.

Menadione (2-methyl-1,4-naphthoquinone)-induced Ca2+ release from rat-liver mitochondria is caused by NAD(P)H oxidation.

S. Orrenius, P. O'Brien, G. Moore, 1986, Xenobiotica; the fate of foreign compounds in biological systems.

Mechanisms of cell toxicity the thiol calcium hypothesis

S. Orrenius, P. Nicotera, D. McConkey, 1988 .

Indirect effects of Bax and Bak initiate the mitochondrial alterations that lead to cytochrome c release during arsenic trioxide-induced apoptosis.

V. Gogvadze, S. Orrenius, L. Nutt, 2005, Cancer biology & therapy.

Differential regulation of the mitochondrial and death receptor pathways in neural stem cells

S. Orrenius, C. Tamm, S. Ceccatelli, 2004, The European journal of neuroscience.

Protease activation in apoptosis induced by MAL.

B. Zhivotovsky, S. Orrenius, A. Hakansson, 1999, Experimental cell research.

NK cell‐induced cytotoxicity is dependent on a Ca2+ increase in the target

S. Orrenius, D. McConkey, S. Chow, 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Translocation of amino acids and glutathione studied with the perfused kidney and isolated renal cells

S. Orrenius, K. Ormstad, K. Ormstad, 1980, FEBS letters.

Isolation and partial characterization of a protease involved in Fas‐induced apoptosis

S. Orrenius, J. Schlegel, I. Peters, 1995, FEBS letters.

The regulation of apoptosis in thymocytes.

S. Orrenius, D. McConkey, M. Jondal, 1994, Biochemical Society transactions.

The role of Ca2+ in cell killing.

S. Orrenius, P. Nicotera, G. Bellomo, 1990, Chemical research in toxicology.

Modifications of Ca2+ signaling by inorganic mercury in PC 12 cells

S. Orrenius, O. Larsson, P. Berggren, 1993, The FASEB Journal.

Glutathione and tissue toxicity

S. Orrenius, G. Bellomo, P. Moldéus, 1984 .

Neuronal apoptosis versus necrosis induced by glutamate or free radicals

S. Lipton, S. Orrenius, P. Nicotera, 1996, Apoptosis.

Role of cardiolipin in cytochrome c release from mitochondria

B. Zhivotovsky, S. Orrenius, M. Ott, 2007, Cell Death and Differentiation.

Effects of serum from patients with type 1 diabetes on primary cerebellar granule cells.

S. Yang, B. Zhivotovsky, S. Orrenius, 2001, Diabetes.

Critical role for hyperpolarization-activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis

G. Silberberg, B. Zhivotovsky, S. Orrenius, 2010, The EMBO journal.

Pyridine-nucleotide oxidation, Ca2+ cycling and membrane damage during tert-butyl hydroperoxide metabolism by rat-liver mitochondria.

S. Orrenius, G. Bellomo, P. Richelmi, 1984, European journal of biochemistry.

Spectral studies on the rapid uptake and subsequent binding of drugs to cytochrome P-450 in isolated rat liver cells.

S. Orrenius, P. Moldéus, C. von Bahr, 1974, Biochemical and biophysical research communications.

Spectral studies on drug-cytochrome P-450 interaction in isolated rat liver cells.

S. Orrenius, P. Moldéus, C. von Bahr, 1973, Biochemical and biophysical research communications.

Alterations in inositol phosphate production during oxidative stress in isolated hepatocytes.

S. Orrenius, G. Bellomo, H. Thor, 1987, The Journal of biological chemistry.

Cleavage of the calpain inhibitor, calpastatin, during apoptosis

Sten Orrenius, S. Orrenius, M. I. Pörn-Ares, 1998, Cell Death and Differentiation.

HAMLET, protein folding, and tumor cell death.

S. Orrenius, J. Pettersson, C. Svanborg, 2007, Biochemical and biophysical research communications.

Cellular signaling in thymocyte apoptosis.

S. Orrenius, D. McConkey, M. Jondal, 1992, Seminars in immunology.

Application of a fluorometric assay to detect caspase activity in thymus tissue undergoing apoptosis in vivo.

B. Zhivotovsky, S. Orrenius, S. Ceccatelli, 1999, Journal of immunological methods.

Glucose and Tolbutamide Induce Apoptosis in Pancreatic β-Cells

B. Zhivotovsky, S. Orrenius, M. Köhler, 1998, The Journal of Biological Chemistry.

The Mitochondrial TOM Complex Is Required for tBid/Bax-induced Cytochrome c Release*

B. Zhivotovsky, S. Orrenius, D. Rapaport, 2007, Journal of Biological Chemistry.

Calcium and cyclosporin A in the regulation of apoptosis.

S. Orrenius, D. McConkey, S. Orrenius, 1995, Current topics in microbiology and immunology.

OVERALL BIOCHEMICAL EFFECTS OF DRUG INDUCTION ON LIVER MICROSOMES

S. Orrenius, M. Das, Y. Gnosspelius, 1969 .

Involvement of extracellular calcium in phosphatidylserine exposure during apoptosis

S. Orrenius, M. Hampton, D. Vanags, 1996, FEBS letters.

Functions of Glutathione in Drug Metabolism

S. Orrenius, D. P. Jones, 1978 .

The future of toxicology--does it matter how cells die?

Sten Orrenius, Boris Zhivotovsky, B. Zhivotovsky, 2006, Chemical research in toxicology.

The role of calcium in pre- and postmitochondrial events in tributyltin-induced T-cell apoptosis.

S. Orrenius, I. Cotgreave, D. Gigliotti, 1999, Biochemical and biophysical research communications.

Caspase-2 Permeabilizes the Outer Mitochondrial Membrane and Disrupts the Binding of Cytochrome c to Anionic Phospholipids*

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2004, Journal of Biological Chemistry.

Solubilization and partial purification of cytochrome P-450 from rat lung microsomes.

S. Orrenius, J. Capdevila, S. Jakobsson, 1975, Biochemical and biophysical research communications.

Detoxification reactions in isolated hepatocytes. Role of glutathione peroxidase, catalase, and formaldehyde dehydrogenase in reactions relating to N-demethylation by the cytochrome P-450 system.

S. Orrenius, D. P. Jones, H. Thor, 1978, The Journal of biological chemistry.

P2x purinoceptor is not important in thymocyte apoptosis.

B. Fredholm, S. Orrenius, B. Kull, 1996, Immunology letters.

Isolated rat hepatocytes as an experimental tool in the study of cell injury. Effect of anoxia.

S. Orrenius, H. Thor, J. Rajs, 1976, Forensic science.

Protective Role of Mitochondrial Vitamin E in Toxic Oxidative Stress

Catherine B. Chan, S. Orrenius, B. V. Houten, 2005 .

2,5-Di(TERT-BUTYL)-1,4-BENZOHYDROQUINONE - TRISPHOSPHATE-SENSITIVE Ca2+ POOL A NOVEL MOBILIZER OF THE INOSITOL 1,4,5-

S. Orrenius, G. Farrell, J. Llopis, 1990 .

2,5-Di(tert-butyl)-1,4-benzohydroquinone--a novel mobilizer of the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool.

S. Orrenius, G. Kass, G. Farrell, 1990, Free radical research communications.

Oxidative Stress‐Induced Plasma Membrane Blebbing and Cytoskeletal Alterations in Normal and Cancer Cells

S. Orrenius, G. Bellomo, M. Vairetti, 1988, Annals of the New York Academy of Sciences.

31 – Toxic Effects of Calcium on Mitochondria

S. Orrenius, G. Bellomo, G. Kass, 1993 .

N-acetyl-p-benzoquinone imine induces Ca2+ release from mitochondria by stimulating pyridine nucleotide hydrolysis.

S. Orrenius, G. Kass, P. Moldéus, 1992, The Journal of biological chemistry.

Ca2+ and endonuclease activation in radiation-induced lymphoid cell death.

B. Zhivotovsky, S. Orrenius, P. Nicotera, 1993, Experimental cell research.

Cell death in human atherosclerotic plaques involves both oncosis and apoptosis.

J. Thyberg, B. Zhivotovsky, S. Orrenius, 1997, Atherosclerosis.

Involvement of Ca2+ and ROS in α‐tocopheryl succinate‐induced mitochondrial permeabilization

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2010, International journal of cancer.

Inorganic mercury modifies Ca2+ signals, triggers apoptosis and potentiates NMDA toxicity in cerebellar granule neurons

B. Zhivotovsky, S. Orrenius, P. Nicotera, 1997, Cell Death and Differentiation.

Inorganic mercury modi ® es Ca 2 + signals , triggers apoptosis and potentiates NMDA toxicity in cerebellar granule neurons

B. Zhivotovsky, S. Orrenius, P. Nicotera, 1997 .

On the effect of cellular nucleophiles on the binding of metabolites of 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene and 9-hydroxybenzo(a)pyrene to nuclear DNA.

S. Orrenius, B. Jernström, T. Guenthner, 1980, Carcinogenesis.

The influence of inducers on drug-metabolizing enzyme activity and on formation of reactive drug metabolites in the liver.

S. Orrenius, B. Jernström, H. Thor, 1980, Ciba Foundation symposium.

Alterations in intracellular calcium compartmentation following inhibition of calcium efflux from isolated hepatocytes.

S. Orrenius, P. Nicotera, G. Bellomo, 1984, European journal of biochemistry.

Fatty acid inducible cy tochrome P-454 of rat kidney cortex microsomes.

S. Orrenius, H. Thor, S. Jakobsson, 1970, Biochemical and biophysical research communications.

Proteases in Fas-mediated apoptosis.

D. H. Burgess, B. Zhivotovsky, S. Orrenius, 1997, Journal of cellular biochemistry.

Familial Hemophagocytic Lymphohistiocytosis: Too Little Cell Death Can Seriously Damage Your Health

S. Orrenius, B. Fadeel, J. Henter, 2001, Leukemia & lymphoma.

Evidence for different localization of glutathione oxidase and gamma-glutamyltransferase activities during extracellular glutathione metabolism in isolated perfused rat kidney.

S. Orrenius, K. Ormstad, T. Låstbom, 1982, Biochimica et Biophysica Acta.

Altered thiol and calcium homeostasis in oxidative hepatocellular injury

S. Orrenius, G. Bellomo, Sten Orrenius, 1985, Hepatology.

Two independently regulated Ca2+ entry mechanisms coexist in Jurkat T cells during T cell receptor antigen activation.

S. Orrenius, G. Kass, S. Chow, 1993, Biochemical Journal.

Role of mitochondria in toxic cell death.

S. Orrenius, J. Robertson, 2002, Toxicology.

Glutathione and Glutathione Conjugate Metabolism in Isolated Liver and Kidney Cells

Dean P. Jones, S. Orrenius, P. Moldéus, 1978 .

Comparison of Serum Bilirubin Levels in Humans and Two Monogastric Animal Species After a Single Administration of Sulfisoxazole

E. Block, N. Benowitz, S. Orrenius, 1982 .

Metabolism of desmethylimipramine in human foetal and adult liver microsomes.

S. Orrenius, A. Rane, F. Sjöqvist, 2009, Acta pharmacologica et toxicologica.

The inhibitory effect of hydrocortisone and testosterone on the plasma disappearance of nortriptyline in the dog and the perfused rat liver.

S. Orrenius, F. Sjöqvist, C. von Bahr, 1970, European journal of pharmacology.

Citrate kills tumor cells through activation of apical caspases

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2012, Cellular and Molecular Life Sciences.

Calcium and signal transduction in oxidative cell damage

S. Orrenius, P. Nicotera, C. J. Duncan, 1991 .

Buried alive: a novel approach to cancer treatment

Sten Orrenius, Shazib Pervaiz, Bengt Fadeel, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

‘Centennial’ Nobel Conference on apoptosis and human disease

B. Zhivotovsky, S. Orrenius, B. Fadeel, 2002, Cell Death and Differentiation.

ENZYME-MEMBRANE RELATIONSHIP IN PHENOBARBITAL INDUCTION OF SYNTHESIS OF DRUG-METABOLIZING ENZYME SYSTEM AND PROLIFERATION OF ENDOPLASMIC MEMBRANES

S. Orrenius, J. Ericsson, 1966, The Journal of cell biology.

Tributyltin causes cytochrome C release from isolated mitochondria by two discrete mechanisms.

V. Gogvadze, S. Orrenius, I. Cotgreave, 2002, Biochemical and biophysical research communications.

Corrigendum to "Reactive oxygen species generated in different compartments induce cell death, survival, or senescence". [Free Radic. Biol. Med. 2013 Apr; 57:176-187.].

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2017, Free radical biology & medicine.

Preparation of antisera against cytochrome b 5 and NADPH-cytochrome c reductase from rat liver microsomes.

S. Orrenius, M. Raftell, 1971, Biochimica et biophysica acta.

Regulation and mechanisms of apoptosis in T lymphocytes.

S. Orrenius, D. J. van den Dobbelsteen, A. Slater, 1996, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

Current Concepts in Cell Toxicity

B. Zhivotovsky, S. Orrenius, Afshin Samali, 1999, Current protocols in toxicology.

Publishing houn of the czechoslovak academy ol sciences. Prague, czechoslovakia. Prlnud in czechoslovakia electron microscopic and biochemical studies of the rat liver microsomes

S. Orrenius, G. Dallner, A. Bergstrand, 1965 .

Constitutive nuclear NF kappa B/rel DNA-binding activity of rat thymocytes is increased by stimuli that promote apoptosis, but not inhibited by pyrrolidine dithiocarbamate.

S. Orrenius, A. Slater, S. Jiang, 1995, The Biochemical journal.

Cell cycle and cell death in disease: past, present and future

B. Zhivotovsky, S. Orrenius, 2010, Journal of internal medicine.

Influence of phenobarbital pretreatment on thein vitro ring a reduction of Δ4-3-oxo-steroids in rat liver microsomes

S. Orrenius, C. Bahr, B. Lisboa, 2005, Naunyn-Schmiedebergs Archiv für Pharmakologie.

REACTION MECHANISMS OF CYTOCHROME P-450

S. Orrenius, 1976 .

Evidence for the presence of an iron sulphur protein in rat kidney cortex microsomes.

S. Orrenius, I. Hoffström, Å. Ellin, 1972, Biochemical and biophysical research communications.

Pharmacokinetics and Metabolism of Sodium 2-Mercaptoethanesulfonate in the Rat 1

S. Orrenius, N. Brock, K. Ormstad, 2006 .

Drug biotransformation and hepatotoxicity. Studies with bromobenzene in isolated hepatocytes.

S. Orrenius, D. J. Reed, J. Högberg, 1978, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

Oxidation of glutathione by free radical intermediates formed during peroxidase‐catalysed N‐demethylation reactions

S. Orrenius, P. Moldéus, P. O'Brien, 1983, FEBS letters.

Citrate kills tumor cells through activation of apical caspases

B. Zhivotovsky, V. Gogvadze, S. Orrenius, 2012, Cellular and Molecular Life Sciences.