N. Gay

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The Drosophila ankyrin repeat protein cactus has a predominantly α‐helical secondary structure

N. Gay, M. Ntwasa, 1993 .

J. Walker, M. Saraste, N. Gay, 1982, The EMBO journal.

A Quantitative Comparison of Single-Dye Tracking Analysis Tools Using Monte Carlo Simulations

D. Klenerman, N. Gay, L. Weimann, 2013, PloS one.

Structural Complementarity of Toll/Interleukin-1 Receptor Domains in Toll-like Receptors and the Adaptors Mal and MyD88*

N. Gay, A. Dunne, L. O’Neill, 2003, Journal of Biological Chemistry.

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

N. Gay, S. Tauszig-Delamasure, H. Gascan, 2003, Nature Immunology.

Adaptors in toll-like receptor signaling and their potential as therapeutic targets.

N. Gay, B. Kobe, A. Mansell, 2012, Current drug targets.

N. Gay, D. Golenbock, K. Fitzgerald, 2006 .

N. Gay, D. Golenbock, K. Fitzgerald, 2006, Proceedings of the National Academy of Sciences of the United States of America.

An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4*

C. Robinson, N. Gay, E. Latz, 2009, The Journal of Biological Chemistry.

Three-tier regulation of cell number plasticity by neurotrophins and Tolls in Drosophila

N. Gay, A. Hidalgo, Bangfu Zhu, 2017, Mechanisms of Development.

The molecular basis of the host response to lipopolysaccharide

D. Spring, N. Gay, C. Bryant, 2010, Nature Reviews Microbiology.

DNA sequence around the Escherichia coli unc operon. Completion of the sequence of a 17 kilobase segment containing asnA, oriC, unc, glmS and phoS.

J. Walker, M. Saraste, N. Gay, 1984, The Biochemical journal.

Toll-like receptor signalling through macromolecular protein complexes.

N. Gay, C. Bryant, M. Symmons, 2015, Molecular immunology.

The atp operon: nucleotide sequence of the genes for the gamma, beta, and epsilon subunits of Escherichia coli ATP synthase.

J. Walker, M. Saraste, N. Gay, 1981, Nucleic acids research.

An Alanine-to-Proline Mutation in the BB-Loop of TLR3 Toll/IL-1R Domain Switches Signalling Adaptor Specificity from TRIF to MyD88

N. Gay, B. Verstak, Christopher J. Arnot, 2013, The Journal of Immunology.

Advances in Toll-like receptor biology: Modes of activation by diverse stimuli

S. Heymans, N. Gay, C. Bryant, 2015, Critical reviews in biochemistry and molecular biology.

DNA sequences of a bovine gene and of two related pseudogenes for the proteolipid subunit of mitochondrial ATP synthase.

J. Walker, N. Gay, M. Dyer, 1989, The Biochemical journal.

Putative link between Polo-like kinases (PLKs) and Toll-like receptor (TLR) signaling in transformed and primary human immune cells

B. Maček, N. Gay, Boumediene Soufi, 2019, Scientific Reports.

ArtinM shares structure , carbohydrate recognition , nd biological effects with native ArtinM erry

N. Gay, M. Roque-Barreira, D. D. Luche, 2015 .

Molecular cloning of a bovine cathepsin.

J. Walker, N. Gay, 1985, Biochemical Journal.

A leucine-rich repeat peptide derived from the Drosophila Toll receptor forms extended filaments with a beta-sheet structure.

N. Gay, J. Barna, L. Packman, 1991, FEBS letters.

Structure of the Glycosyltransferase EryCIII in Complex with its Activating P450 Homologue EryCII

P. Leadlay, N. Gay, B. Luisi, 2012, Journal of molecular biology.

Sensing of Gram‐positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP‐SA

N. Gay, P. Ligoxygakis, M. Atilano, 2006, The EMBO journal.

Role of self-organising myddosome oligomers in inflammatory signalling by Toll-like receptors

N. Gay, 2019, BMC Biology.

The N-terminal loop of IRAK-4 death domain regulates ordered assembly of the Myddosome signalling scaffold

N. Gay, C. Bryant, M. Symmons, 2016, Scientific Reports.

Wild type and constitutively activated forms of the Drosophila Toll receptor have different patterns of N‐linked glycosylation

N. Gay, F. Keith, K. Kubota, 1995, FEBS letters.

Insertion of transposon Tn7 into the Escherichia coli glmS transcriptional terminator.

J. Walker, N. Gay, V. Tybulewicz, 1986, The Biochemical journal.

Identification of the glmU Gene Encoding N-Acetylglucosamine-1-Phosphate Uridyltransferase in Escherichia coli

M. Saraste, N. Gay, 2003 .

The TLR4 D299G and T399I SNPs Are Constitutively Active to Up-Regulate Expression of Trif-Dependent Genes

E. El-Omar, N. Gay, C. Mayer, 2014, PloS one.

Expression and subcellular distribution of rel/NFκB transcription factors in the preimplantation mouse embryo: novel κB binding activities in the blastocyst stage embryo

N. Gay, J. Parrott, Justine N. Parrott, 1998, Zygote.

ATP synthase from bovine mitochondria: sequences of imported precursors of oligomycin sensitivity conferral protein, factor 6, and adenosinetriphosphatase inhibitor protein.

J. Walker, N. Gay, S. Powell, 1987, Biochemistry.

The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming

A. Sher, N. Gay, M. Roque-Barreira, 2019, PLoS pathogens.

Saturation of acyl chains converts cardiolipin from an antagonist to an activator of Toll-like receptor-4

N. Gay, J. Ruysschaert, C. Bryant, 2019, Cellular and Molecular Life Sciences.

Molecular and Cellular Regulation of Toll-Like Receptor-4 Activity Induced by Lipopolysaccharide Ligands

N. Gay, Ardiyanto Liaunardy-Jopeace, 2014, Front. Immunol..

Alpha-adaptin, a marker for endocytosis, is expressed in complex patterns during Drosophila development.

N. Gay, A. Jackson, S. Dornan, 1997, Molecular biology of the cell.

a-Adaptin, a Marker for Endocytosis, Is Expressed in Complex Patterns during Drosophila Development

N. Gay, A. Jackson, S. Dornan, 2022 .

University of Birmingham Toll-6 and Toll-7 function as neurotrophin receptors in the Drosophila melanogaster CNS

N. Gay, A. Hidalgo, Istvan Foldi, 2013 .

X-ray diffraction and far-UV CD studies of filaments formed by a leucine-rich repeat peptide: structural similarity to the amyloid fibrils of prions and Alzheimer's disease beta-protein.

N. Gay, D. Clarke, G. Jones, 1997, FEBS letters.

Anterograde Trafficking of Toll-Like Receptors Requires the Cargo Sorting Adaptors TMED-2 and 7 and specific N-glycans

N. Gay, M. Symmons, M. Moncrieffe, 2022, bioRxiv.

Peptidoglycan recognition protein-SD provides versatility of receptor formation in Drosophila immunity

N. Gay, R. Gilbert, P. Ligoxygakis, 2008, Proceedings of the National Academy of Sciences.

A leucine‐rich repeat peptide derived from the Drosophila Toll receptor forms extended filaments with a β‐sheet structure

N. Gay, J. Barna, L. Packman, 1991 .

Kek-6: A truncated-Trk-like receptor for Drosophila neurotrophin 2 regulates structural synaptic plasticity

N. Gay, A. Hidalgo, S. Bishop, 2017, bioRxiv.

Elucidation of the MD-2/TLR4 Interface Required for Signaling by Lipid IVa1

D. Maskell, N. Gay, C. Bryant, 2008, The Journal of Immunology.

Toll-like receptors as molecular switches

N. Gay, A. Weber, M. Gangloff, 2006, Nature Reviews Immunology.

Therapeutic Administration of Recombinant Paracoccin Confers Protection against Paracoccidioides brasiliensis Infection: Involvement of TLRs

T. D. da Silva, N. Gay, M. Roque-Barreira, 2014, PLoS neglected tropical diseases.

The unc operon. Nucleotide sequence, regulation and structure of ATP-synthase.

J. Walker, M. Saraste, N. Gay, 1984, Biochimica et biophysica acta.

High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity.

Xue Yuan Pei, Adrian F Bristow, N. Gay, 2003, Biochemistry.

Activating immunity: lessons from the TLRs and NLRs.

N. Gay, C. Bryant, T. Monie, 2009, Trends in biochemical sciences.

Toll-6 and Toll-7 function as neurotrophin receptors in the Drosophila central nervous system

N. Gay, A. Hidalgo, Istvan Foldi, 2013, Nature Neuroscience.

A family of proteins related to Spätzle, the toll receptor ligand, are encoded in the Drosophila genome

K. Mizuguchi, N. Gay, J. Parker, 2001, Proteins.

The atp operon: nucleotide sequence of the promoter and the genes for the membrane proteins, and the delta subunit of Escherichia coli ATP-synthase.

J. Walker, N. Gay, 1981, Nucleic acids research.

Assembly and localization of Toll-like receptor signalling complexes

Martyn F. Symmons, N. Gay, C. Bryant, 2014, Nature Reviews Immunology.

Toll-like receptor 2 promiscuity is responsible for the immunostimulatory activity of nucleic acid nanocarriers

D. Scherman, N. Gay, J. Ruysschaert, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Assembly of Oligomeric Death Domain Complexes during Toll Receptor Signaling*

N. Gay, M. Moncrieffe, J. Grossmann, 2008, Journal of Biological Chemistry.

Structure and function of Toll receptors and their ligands.

N. Gay, M. Gangloff, Monique Gangloff, 2007, Annual review of biochemistry.

Characterisation of the gene for Drosophila amphiphysin.

K. Mizuguchi, N. Gay, A. Jackson, 2000, Gene.

Activation of Toll-like receptor 4 by Ebola virus-shed glycoprotein is direct and requires the internal fusion loop but not glycosylation

N. Gay, M. Scherm, M. Gangloff, 2022, Cell reports.

Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design

H. M. Nielsen, N. Gay, W. van Eden, 2018, Molecular therapy. Nucleic acids.

Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub

Nils A. Berglund, P. Cicuta, D. Klenerman, 2018, eLife.

Critical residues involved in Toll-like receptor 4 activation by cationic lipid nanocarriers are not located at the lipopolysaccharide-binding interface

N. Gay, J. Ruysschaert, Kate L. Irvine, 2015, Cellular and Molecular Life Sciences.

Identification of Key Residues That Confer Rhodobacter sphaeroides LPS Activity at Horse TLR4/MD-2

D. Spring, N. Gay, Kate L. Irvine, 2014, PloS one.

Cytokine Spätzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation

N. Gay, A. Ashcroft, M. Gangloff, 2013, Proceedings of the National Academy of Sciences.

Allergens as Immunomodulatory Proteins: The Cat Dander Protein Fel d 1 Enhances TLR Activation by Lipid Ligands

Heather Brooks, Clare Bryant, H. Grönlund, 2013, The Journal of Immunology.

Functional Insights from the Crystal Structure of the N-Terminal Domain of the Prototypical Toll Receptor

N. Gay, M. Gangloff, Christopher J. Arnot, 2013, Structure.

LPS ligand and culture additives improve production of monomeric MD-1 and 2 in Pichia pastoris by decreasing aggregation and intermolecular disulfide bonding

N. Gay, C. Bryant, Kristen E. Mengwasser, 2011, Protein expression and purification.

What the Myddosome structure tells us about the initiation of innate immunity.

N. Gay, L. O’Neill, M. Gangloff, 2011, Trends in immunology.

Ligand-Receptor and Receptor-Receptor Interactions Act in Concert to Activate Signaling in the Drosophila Toll Pathway*♦

N. Gay, J. Imler, A. Weber, 2005, Journal of Biological Chemistry.

Structural and functional diversity in the leucine-rich repeat family of proteins.

N. Gay, S. G. Buchanan, Sean G.St.C. Buchanan, 1996, Progress in biophysics and molecular biology.

Primary structure and subunit stoichiometry of F1-ATPase from bovine mitochondria.

J. Walker, M. Saraste, B. Gibson, 1985, Journal of molecular biology.

Four N-linked Glycosylation Sites in Human Toll-like Receptor 2 Cooperate to Direct Efficient Biosynthesis and Secretion*

N. Gay, A. Weber, M. Morse, 2004, Journal of Biological Chemistry.

Homology between human bladder carcinoma oncogene product and mitochondrial ATP-synthase

N. Gay, J. Walker, 1983, Nature.

Drosophila ribosomal protein L18a: cDNA sequence, expression and chromosomal localization of the gene.

N. Gay, M. Ntwasa, S. G. Buchanan, 1994, Biochimica et biophysica acta.

Impact of mutations in Toll-like receptor pathway genes on esophageal carcinogenesis

N. Gay, M. O’Donovan, R. Fitzgerald, 2017, PLoS genetics.

1 1 KEK-6 : A TRUNCATED-TRK-LIKE RECEPTOR FOR DROSOPHILA NEUROTROPHIN 2 2 REGULATES STRUCTURAL SYNAPTIC PLASTICITY 3 4 5

N. Gay, A. Hidalgo, S. Bishop, 2017 .

Two genes encoding the bovine mitochondrial ATP synthase proteolipid specify precursors with different import sequences and are expressed in a tissue‐specific manner.

J. Walker, N. Gay, 1985, The EMBO journal.

Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti

N. Gay, D. Chirgadze, S. Hardwick, 2021, Nature Communications.

Structure and dynamics of pathway activation by the Toll immunoreceptor from the viral mosquito vector Aedes aegypti

N. Gay, D. Chirgadze, S. Hardwick, 2021 .

Viral tolerance in Aedes aegypti relies on the negative cooperativity between Toll5A and the cytokine ligand Spz1C

N. Gay, D. Chirgadze, S. Hardwick, 2021 .

Structure and regulation of cytoplasmic adapter proteins involved in innate immune signaling

N. Gay, M. Moncrieffe, T. Monie, 2009, Immunological reviews.

Sequence and expression of Drosophila myristoyl-CoA: protein N-myristoyl transferase: evidence for proteolytic processing and membrane localisation.

N. Gay, M. Ntwasa, M. Egerton, 1997, Journal of cell science.

The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4

A. Bowie, N. Gay, E. Latz, 2014, Journal of leukocyte biology.

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.

S. Akira, N. Gay, Masahiro Yamamoto, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Structure of toll-like receptors.

N. Gay, M. Gangloff, 2008, Handbook of experimental pharmacology.

Regulation of translation and proteolysis during the development of embryonic dorso-ventral polarity in Drosophila. Homology of easter proteinase with Limulus proclotting enzyme and translational activation of Toll receptor synthesis.

N. Gay, F. Keith, N. J. Gay, 1992, Biochimica et biophysica acta.

Targeting and Recognition of Toll-Like Receptors by Plant and Pathogen Lectins

N. Gay, M. Roque-Barreira, R. Ricci-Azevedo, 2017, Front. Immunol..

Drosophila Toll and IL-1 receptor

N. Gay, F. Keith, 1991, Nature.

ATP synthase from bovine mitochondria: complementary DNA sequence of the mitochondrial import precursor of the gamma-subunit and the genomic sequence of the mature protein.

J. Walker, N. Gay, S. Powell, 1989, Biochemistry.

MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling

D. Klenerman, P. Penczek, N. Gay, 2020, Structure.

Two Human MYD88 Variants, S34Y and R98C, Interfere with MyD88-IRAK4-Myddosome Assembly

N. Gay, A. Rautanen, A. Hill, 2010, The Journal of Biological Chemistry.

Solution structure of the isolated Pelle death domain

N. Gay, K. Stott, M. Moncrieffe, 2005, FEBS letters.

Formation and biochemical characterization of tube/pelle death domain complexes: critical regulators of postreceptor signaling by the Drosophila toll receptor.

N. Gay, S. Harding, R. Solari, 1999, Biochemistry.

X‐ray diffraction and far‐UV CD studies of filaments formed by a leucine‐rich repeat peptide: structural similarity to the amyloid fibrils of prions and Alzheimer's disease β‐protein

N. Gay, D. Clarke, M. Symmons, 1997 .

The atp operon: nucleotide sequence of the region encoding the alpha-subunit of Escherichia coli ATP-synthase.

J. Walker, N. Gay, 1981, Nucleic acids research.

MD-2: the Toll 'gatekeeper' in endotoxin signalling.

N. Gay, M. Gangloff, 2004, Trends in biochemical sciences.

A Dimer of the Toll-Like Receptor 4 Cytoplasmic Domain Provides a Specific Scaffold for the Recruitment of Signalling Adaptor Proteins

N. Gay, C. Bryant, L. O’Neill, 2007, PloS one.

Liesegang-like patterns of Toll crystals grown in gel

N. Gay, A. Moreno, M. Gangloff, 2013, Journal of applied crystallography.

Construction and characterization of an Escherichia coli strain with a uncI mutation

N. Gay, 1984, Journal of bacteriology.

The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane

N. Gay, C. Bryant, Ardiyanto Liaunardy-Jopeace, 2014, Science Signaling.

Conserved mechanisms of signal transduction by Toll and Toll-like receptors.

N. Gay, A. Weber, M. Gangloff, 2005, Journal of endotoxin research.

Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila.

N. Gay, J. Skepper, A. Jackson, 2001, Genes & development.

Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons

N. Gay, C. Bryant, John A. Wright, 2018, Neuropharmacology.

Drosophila embryos lacking N-myristoyltransferase have multiple developmental defects.

N. Gay, M. Ntwasa, D. Schiffmann, 2001, Experimental cell research.

The signal transduction pathway leading from the toll receptor to nuclear localization of dorsal transcription factor.

N. Gay, K. Kubota, 1996, Biochemical Society transactions.

Structural Insight into the Mechanism of Activation of the Toll Receptor by the Dimeric Ligand Spätzle*

C. Robinson, N. Gay, A. Sandercock, 2008, Journal of Biological Chemistry.

Baseless assumptions: activation of TLR9 by DNA.

N. Gay, M. Gangloff, 2008, Immunity.

Negative Regulation of TLR Signaling by BCAP Requires Dimerization of Its DBB Domain

N. Gay, David I. Fisher, M. Scherm, 2020, The Journal of Immunology.

A TIR Domain Variant of MyD88 Adapter-like (Mal)/TIRAP Results in Loss of MyD88 Binding and Reduced TLR2/TLR4 Signaling*

Douglas T. Golenbock, Katherine A. Fitzgerald, Mihai G. Netea, 2009, The Journal of Biological Chemistry.

The Parkinson's disease–associated kinase LRRK2 regulates genes required for cell adhesion, polarization, and chemotaxis in activated murine macrophages

N. Gay, C. Bryant, M. Symmons, 2020, The Journal of Biological Chemistry.

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

F. DiMaio, M. Sweet, N. Gay, 2011, Proceedings of the National Academy of Sciences.

Getting knotted: a model for the structure and activation of Spätzle.

K. Mizuguchi, T. Blundell, N. Gay, 1998, Trends in biochemical sciences.

E. coli F1-ATPase interacts with a membrane protein component of a proton channel

M. Saraste, N. Gay, J. Walker, 1982, Nature.

The Drosophila membrane receptor Toll can function to promote cellular adhesion.

N. Gay, F. Keith, N. J. Gay, 1990, The EMBO journal.

Conserved Features in the Extracellular Domain of Human Toll-like Receptor 8 Are Essential for pH-dependent Signaling*

N. Gay, P. Morley, R. J. Gibbard, 2006, Journal of Biological Chemistry.

Molecular Mechanism That Induces Activation of Spätzle, the Ligand for the Drosophila Toll Receptor

N. Gay, M. Gangloff, Christopher J. Arnot, 2010, The Journal of Biological Chemistry.

Role of the Spätzle Pro-domain in the Generation of an Active Toll Receptor Ligand*

N. Gay, J. Imler, A. Weber, 2007, Journal of Biological Chemistry.

Activation of insect and vertebrate toll signaling: from endogenous cytokine ligand to direct recognition of pathogen patterns.

N. Gay, A. Weber, M. Gangloff, 2005, Advances in experimental medicine and biology.

The dorsal protein enhances the biosynthesis and stability of the Drosophila I kappa B homologue cactus.

N. Gay, K. Kubota, 1995, Nucleic acids research.

Phosphorylation of the multifunctional signal transducer B-cell adaptor protein (BCAP) promotes recruitment of multiple SH2/SH3 proteins including GRB2

N. Gay, Delphine De Sutter, S. Eyckerman, 2019, The Journal of Biological Chemistry.

The Drosophila engrailed protein is phosphorylated by a serine-specific protein kinase.

T. Kornberg, N. Gay, S. Poole, 1988, Nucleic acids research.

Evolutionary relationships, but functional differences, between the Drosophila and human Toll-like receptor families.

N. Gay, A. Weber, M. Gangloff, 2003, Biochemical Society transactions.

Conserved mechanisms of signal transduction by Toll and Toll-like receptors

N. Gay, A. Weber, M. Gangloff, 2005 .

The nonsense-mediated decay RNA surveillance pathway.

D. Cane, C. Robinson, N. Gay, 2007, Annual review of biochemistry.

Expression and subcellular distribution of rel/NFκB transcription factors in the preimplantation mouse embryo: novel κB binding activities in the blastocyst stage embryo

N. Gay, Justine N. Parrott, 1999 .

Anthrax toxin: receptor binding, internalization, pore formation, and translocation.

John A. Young, D. Cane, C. Robinson, 2007, Annual review of biochemistry.

Sequence and expression of LRR47, a novel embryonic leucine rich repeat protein of Drosophila.

N. Gay, M. Ntwasa, S. G. Buchanan, 1994, Biochimica et biophysica acta.

Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub

Nils A. Berglund, P. Cicuta, D. Klenerman, 2018, eLife.

Chemical evolution as a tool for molecular discovery.

D. Cane, C. Robinson, P. Harbury, 2007, Annual review of biochemistry.

Formation of a gradient of the Drosophila dorsal morphogen by differential nuclear localisation.

N. Gay, F. Keith, 1990, BioEssays : news and reviews in molecular, cellular and developmental biology.

Structure of the Toll/Interleukin-1 Receptor (TIR) Domain of the B-cell Adaptor That Links Phosphoinositide Metabolism with the Negative Regulation of the Toll-like Receptor (TLR) Signalosome*

N. Gay, Eiki Sekine, M. Moncrieffe, 2016, The Journal of Biological Chemistry.

Peptidoglycan recognition protein-SD provides versatility of receptor formation in Drosophila immunity

N. Gay, R. Gilbert, P. Ligoxygakis, 2008, Proceedings of the National Academy of Sciences.

Casein kinase II phosphorylates Ser468 in the PEST domain of the Drosophila IκB homologue cactus

N. Gay, J. Parker, L. Packman, 1997 .