H. Fraser

发表

Decontamination studies with the agents of bovine spongiform encephalopathy and scrapie

D. Taylor, H. Fraser, I. Mcconnell, 2005, Archives of Virology.

Transmissions to mice indicate that ‘new variant’ CJD is caused by the BSE agent

S. Cousens, H. Fraser, I. Mcconnell, 1997, Nature.

Follicular dendritic cells in scrapie pathogenesis.

H. Fraser, K. Brown, W. Morrison, 2000, Archives of virology. Supplementum.

Severely combined immunodeficient (SCID) mice resist infection with bovine spongiform encephalopathy.

H. Fraser, K. Brown, M. Bruce, 1997, The Journal of general virology.

Replication of scrapie in spleens of SCID mice follows reconstitution with wild-type mouse bone marrow.

H. Fraser, I. Mcconnell, K. Brown, 1996, The Journal of general virology.

Mouse Inoculation Studies Reveal No Transmissible Agent in Amyotrophic Lateral Sclerosis

H. Fraser, P. Behan, W. Behan, 1996, Brain pathology.

Scrapie: Pathogenesis in Inbred Mice: An Assessment of Host Control and Response Involving Many Strains of Agent

H. Fraser, A. Dickinson, 1977 .

Scrapie incubation time can exceed natural lifespan

H. Fraser, A. Dickinson, G. Outram, 1975, Nature.

Ultrastructural features of spongiform encephalopathy transmitted to mice from three species of bovidae

H. Fraser, A. Williams, M. Jeffrey, 2004, Acta Neuropathologica.

Possible origin of the scrapie genome in small endogenous RNAs; studies on eight candidate species in 263K scrapie-infected hamster brain

R. Lathe, H. Fraser, R. Duncan, 2019, bioRxiv.

Transmission of feline spongiform encephalopathy to mice

H. Fraser, I. Mcconnell, M. Bruce, 1994, Veterinary Record.

EVIDENCE THAT TRANSMISSIBLE MINK ENCEPHALOPATHY AGENT IS BIOLOGICALLY INACTIVE IN MICE

D. Taylor, H. Fraser, A. Dickinson, 1986, Neuropathology and applied neurobiology.

Genetical control of the concentration of ME7 scrapie agent in mouse spleen.

H. Fraser, A. Dickinson, 1969, Journal of comparative pathology.

Genetical control of the concentration of ME7 scrapie agent in the brain of mice.

H. Fraser, A. Dickinson, V. M. Meikle, 1969, Journal of comparative pathology.

Transmission of bovine spongiform encephalopathy to mice

H. Fraser, I. Mcconnell, M. Dawson, 1988, Veterinary Record.

Extraneural competition between different scrapie agents leading to loss of infectivity

D. Taylor, H. Fraser, I. Mcconnell, 1975, Nature.

Competition between different scrapie agents in mice.

H. Fraser, A. Dickinson, G. Outram, 1972, Nature: New biology.

Distribution of Experimentally Induced Scrapie Lesions in the Brain

H. Fraser, A. Dickinson, 1967, Nature.

Transmission of Bovine Spongiform Encephalopathy to Sheep, Goats, and Mice

H. Fraser, I. Mcconnell, J. Foster, 1994, Annals of the New York Academy of Sciences.

Transmission of bovine spongiform encephalopathy and scrapie to mice.

H. Fraser, I. Mcconnell, J. Foster, 1992, The Journal of general virology.

THE MOLECULAR PATHOLOGY OF SCRAPIE AND THE BIOLOGICAL BASIS OF LESION TARGETING

H. Fraser, J. Scott, P. McBride, 1989, Progress in clinical and biological research.

PREPARATION OF GROWTH HORMONE FREE FROM CONTAMINATION WITH UNCONVENTIONAL SLOW VIRUSES

H. Fraser, A. Dickinson, P. Robertson, 1985, The Lancet.

Ionising radiation has no influence on scrapie incubation period in mice.

H. Fraser, C. Farquhar, 1987, Veterinary microbiology.

Cerebral amyloid plaques in Alzheimer’s disease but not in scrapie-affected mice are closely associated with a local inflammatory process

H. Fraser, P. Eikelenboom, F. Stam, 1991, Virchows Archiv. B, Cell pathology including molecular pathology.

The use of monosodium glutamate in identifying neuronai populations in mice infected with scrapie

H. Fraser, J. Foster, J. Foster, 1990, Neuropathology and applied neurobiology.

EFFECT OF ROUTE OF INFECTION ON THE FREQUENCY AND DISTRIBUTION OF CEREBRAL AMYLOID PLAQUES IN SCRAPIE MICE

H. Fraser, M. Bruce, 1981, Neuropathology and applied neurobiology.

Infectious etiology of neuritic (senile) plaques in mice

H. Wiśniewski, H. Fraser, M. Bruce, 1975, Science.

AMYLOID PLAQUES IN THE BRAINS OF MICE INFECTED WITH SCRAPIE: MORPHOLOGICAL VARIATION AND STAINING PROPERTIES

H. Fraser, M. Bruce, 1975 .

Human T-lymphotropic virus type I DNA in spinal cord of tropical spastic paraparesis with concomitant human T-lymphotropic virus type I-negative Hodgkin's disease.

E. Jaffe, H. Fraser, G. Román, 1994, Human pathology.

No evidence for involvement of plasma proteins or blood-borne cells in amyloid plaque formation in scrapie-affected mice

H. Fraser, P. Eikelenboom, J. Scott, 1987, Virchows Archiv. B, Cell pathology including molecular pathology.

PrP protein is associated with follicular dendritic cells of spleens and lymph nodes in uninfected and scrapie‐infected mice

H. Fraser, P. Eikelenboom, G. Kraal, 1992, The Journal of pathology.

The Blood-Brain Barrier in Cerebral Amyloidogenesis in Alzheimer’s Disease and Scrapie

H. Fraser, P. Eikelenboom, F. Stam, 1988 .

REDUCED CHOLINE-ACETYLTRANSFERASE ACTIVITY IN SCRAPIE MOUSE BRAIN

H. Fraser, A. Dickinson, J. Mcdermott, 1978, The Lancet.

TRANSPORT AMD TARGETING OF SCRAPIE INFECTIVITY AND PATHOLOGY IN THE OPTIC NERVE PROJECTIONS FOLLOWING INTRAOCULAR INFECTION

H. Fraser, J. Scott, 1989, Progress in clinical and biological research.

Scrapie inoculation of mice: light and electron microscopy of the superior colliculi

H. Fraser, M. Jeffrey, J. Scott, 2004, Acta Neuropathologica.

THE SCRAPIE DISEASE PROCESS IS UNAFFECTED BY IONISING RADIATION

H. Fraser, I. Mcconnell, C. Farquhar, 1989, Progress in clinical and biological research.

Conjunctival instillation of scrapie in mice can produce disease.

H. Fraser, J. Foster, J. Scott, 1993, Veterinary microbiology.

Altered clinical and histological features of male MM mouse pyelonephritis associated with a change in its microbiology

D. Taylor, H. Fraser, M. Bruce, 1988, Laboratory animals.

Immunocytochemical appearance of cytokines, prostaglandin E2 and lipocortin-1 in the CNS during the incubation period of murine scrapie correlates with progressive PrP accumulations

H. Fraser, P. Eikelenboom, D. Ritchie, 1997, Brain Research.

Characterization of the microglial response in murine scrapie

V. Perry, H. Fraser, L. Lawson, 1994, Neuropathology and applied neurobiology.

Experimentally induced bovine spongiform encephalopathy did not transmit via goat embryos.

H. Fraser, N. Hunter, J. Foster, 1999, The Journal of general virology.

Embryos and uterine flush fluids from cattle with bovine spongiform encephalopathy are not infective for mice

H. Fraser, A. Chree, A. Wrathall, 1997 .

Studies on maternal transmission of scrapie in sheep by embryo transfer

H. Fraser, N. Hunter, J. Foster, 1992, Veterinary Record.

Argyrophilic plaques in mice inoculated with scrapie from particular sources.

H. Fraser, M. Bruce, 1973, Lancet.

The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis.

H. Fraser, I. Mcconnell, A. Dickinson, 1991, The Journal of general virology.

Identification of a gene which controls the incubation period of some strains of scrapie agent in mice.

H. Fraser, A. Dickinson, V. M. Meikle, 1968, Journal of comparative pathology.

Strain characterization of natural sheep scrapie and comparison with BSE.

S. Cousens, H. Fraser, I. Mcconnell, 2002, The Journal of general virology.

Scrapie strain variation and its implications.

H. Fraser, M. Bruce, 1991, Current topics in microbiology and immunology.

CEREBRAL AMYLOIDOSIS IN SCRAPIE IN THE MOUSE: EFFECT OF AGENT STRAIN AND MOUSE GENOTYPE

H. Fraser, A. Dickinson, M. Bruce, 1976 .

Scrapie in mice. Agent-strain differences in the distribution and intensity of grey matter vacuolation.

H. Fraser, A. Dickinson, 1973, Journal of comparative pathology.

Hydronephrosis in inbred strains of mice with particular reference to the BRVR strain

D. Taylor, H. Fraser, 1973, Laboratory animals.

Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells

H. Fraser, K. Brown, N. Mabbott, 1999, Nature Medicine.

Scrapie in immunodeficient mice.

H. Fraser, M. Bruce, K. Stewart, 1997, Biochemical Society transactions.

Cytokines, prostaglandins and lipocortin-1 are present in the brains of scrapie-infected mice

H. Fraser, P. Eikelenboom, A. Williams, 1994, Brain Research.

Scrapie infection can be established readily through skin scarification in immunocompetent but not immunodeficient mice.

D. Taylor, H. Fraser, I. Mcconnell, 1996, The Journal of general virology.

Targeting of scrapie lesions and spread of agent via the retino-tectal projection

H. Fraser, A. Dickinson, 1985, Brain Research.

Neuronal spread of scrapie agent and targeting of lesions within the retino-tectal pathway

H. Fraser, 1982, Nature.

Reduced susceptibility to scrapie in mice after steroid administration

H. Fraser, A. Dickinson, G. Outram, 1974, Nature.

Depression of polymorph counts by various scrapie agents

D. Taylor, H. Fraser, A. Dickinson, 1974, Nature.

researchers who have dominated the field since the mid-1980 s and some of whom are still active in the field

H. Wiśniewski, B. Caughey, H. Fraser, 2012 .

The genomic identity of different strains of mouse scrapie is expressed in hamsters and preserved on reisolation in mice.

H. Fraser, R. Kimberlin, C. Walker, 1989, The Journal of general virology.

The sequential development of the brain lesion of scrapie in three strains of mice.

H. Fraser, A. Dickinson, 1968, Journal of comparative pathology.

Parallels and Contrasts Between Scrapie and Dementia of the Alzheimer Type and Ageing: Strategies and Problems for Experiments Involving Life Span Studies

H. Fraser, P. McBride, 1985 .

Developmental Maturation of Susceptibility to Scrapie in Mice

H. Fraser, A. Dickinson, G. Outram, 1973, Nature.

Pathogenesis of Scrapie in the Mouse: the Role of the Spleen

H. Fraser, A. Dickinson, 1970, Nature.

THE CORRELATION OF ELECTRORETINOGRAPHIC AND HISTOPATHOLOGICAL FINDINGS IN THE EYES OF MICE INFECTED WITH THE 79A STRAIN OF SCRAPIE

H. Fraser, J. Foster, J. Scott, 1989, Neuropathology and applied neurobiology.

RETINOPATHY IN MICE WITH EXPERIMENTAL SCRAPIE

H. Fraser, J. Foster, M. Bruce, 1986, Neuropathology and applied neurobiology.

Studies of embryo transfer from cattle clinically affected by bovine spongiform encephalopathy (BSE)

H. Fraser, M. Simmons, A. Chree, 2002, Veterinary Record.

Transmission of bovine spongiform encephalopathy to sheep and goats

H. Fraser, J. Foster, J. Hope, 1993, Veterinary Record.

Scrapie in the central nervous system: neuroanatomical spread of infection and Sinc control of pathogenesis.

H Fraser, H. Fraser, J. Scott, 1992, The Journal of general virology.

Enucleation after intraocular scrapie injection delays the spread of infection

H. Fraser, J. Scott, J. R. Scott, 1989, Brain Research.

Scrapie in mice. Some effects on the brain lesion profile of ME7 agent due to genotype of donor, route of injection and genotype of recipient.

H. Fraser, D. Wilson, G. Outram, 1973, Journal of comparative pathology.

Transmission of bovine spongiform encephalopathy and scrapie to mice.

H. Fraser, I. Mcconnell, A. Chree, 1992, The Journal of general virology.

Experimental control of cerebral amyloid in scrapie in mice.

H. Fraser, M. Bruce, 1983, Progress in brain research.

Modification of the Pathogenesis of Scrapie in Mice by Treatment of the Agent

H. Fraser, A. Dickinson, 1969, Nature.

IMMUNOSTAINING OF SCRAPIE CEREBRAL AMYLOID PLAQUES WITH ANTISERA RAISED TO SCRAPIE–ASSOCIATED FIBRILS (SAF)

H. Fraser, P. McBride, M. E. Bruce, 1988, Neuropathology and applied neurobiology.

EFFECTS OF AGE ON CEREBRAL AMYLOID PLAQUES IN MURINE SCRAPIE

H. Fraser, M. Bruce, 1982, Neuropathology and applied neurobiology.

THE PATHOGENESIS AND PATHOLOGY OF SCRAPIE

H. Fraser, 1979 .

Studies of the lymphoreticular system in the pathogenesis of scrapie: the role of spleen and thymus.

H. Fraser, A. Dickinson, 1978, Journal of comparative pathology.

An investigation of the macrophage electrophoretic mobility test in the diagnosis of scrapie in sheep.

H. Fraser, P. Hancock, 1977, Journal of comparative pathology.

Detection of BSE infectivity in brain and spleen of experimentally infected sheep

H. Fraser, I. Mcconnell, J. Foster, 1996, Veterinary Record.

Detection of apoptosis in murine scrapie

H. Fraser, P. Lucassen, A. Williams, 1995, Neuroscience Letters.

Mitogenic stimulation of the host enhances susceptibility to scrapie

H. Fraser, I. Mcconnell, A. Dickinson, 1978, Nature.

Amyloid scrapie plaques in mice, and Alzheimer senile plaques, share common antigens with tau, a microtubule-associated protein

H. Fraser, A. Dickinson, J. Brion, 1987, Neuroscience Letters.

Degenerative hippocampal pathology in mice infected with scrapie

H. Fraser, J. Scott, 2004, Acta Neuropathologica.

Diversity in the neuropathology of scrapie-like diseases in animals.

H. Fraser, 1993, British medical bulletin.

SLOW ENCEPHALOPATHIES, INFLAMMATORY RESPONSES, AND ARACHIS OIL

H. Fraser, A. Dickinson, G. Outram, 1975, The Lancet.

Observations on the transmission of scrapie in experiments using embryo transfer

H. Fraser, N. Hunter, J. Foster, 1996, Veterinary Record.

Studies ofembryo transfer from cattle

H. Fraser, M. Simmons, A. Chree, 2013 .

Scrapie: Effect of Dh gene on incubation period of extraneurally injected agent

H. Fraser, A. Dickinson, 1972, Heredity.

Scrapie associated fibrils in the diagnosis of scrapie in sheep

H. Fraser, R. Somerville, J. Foster, 1987, Veterinary Record.

The basis of strain variation in scrapie.

H. Fraser, A. Dickinson, P. McBride, 1992 .

Cytokines, prostaglandins and lipocortin-1 are present in the brains of scrapie-infected mice

H. Fraser, Alun Williams, F. Berkenbosch, 1994, Journal of Neuroimmunology.

Focal and asymmetrical vacuolar lesions in the brains of mice infected with certain strains of scrapie

H. Fraser, M. Bruce, 2004, Acta Neuropathologica.