J. Otero

发表

Implementation of QbD for the development of a vaccine candidate.

Andrew Franklin, Jennifer Haas, Matthew Houser, 2014, Vaccine.

Industrial systems biology.

J. Nielsen, J. Otero, 2010, Biotechnology and bioengineering.

Chapter 2. Industrial Systems Biology

J. Nielsen, J. Otero, 2010 .

Industrial Systems Biology of Saccharomyces cerevisiae Enables Novel Succinic Acid Cell Factory

J. Nielsen, K. Patil, J. Otero, 2013, PloS one.

Design, Synthesis, and Structural Analysis of Turn Modified cyclo-(αβ3αβ2α)2 Peptide Derivatives toward Crystalline Hexagon-Shaped Cationic Nanochannel Assemblies

D. Filippov, H. Overkleeft, J. Otero, 2013 .

A prodrug approach for improving antituberculosis activity of potent Mycobacterium tuberculosis type II dehydroquinase inhibitors.

J. Otero, A. Hawkins, C. González‐Bello, 2011, Journal of medicinal chemistry.

Structure of the bacteriophage T4 long tail fiber receptor-binding tip

J. Otero, R. Kahn, G. Fox, 2010, Proceedings of the National Academy of Sciences.

Whole genome sequencing of Saccharomyces cerevisiae: from genotype to phenotype for improved metabolic engineering applications

J. Nielsen, L. Farinelli, J. Otero, 2010, BMC Genomics.

Electrocardiographic findings in mdx mice: A cardiac phenotype of Duchenne muscular dystrophy

J. Otero, I. Amende, T. Hampton, 2002, Muscle & nerve.

Title Yeast biological networks unfold the interplay of antioxidants , genome and phenotype , and reveal a novel regulator of the oxidative stress response

J. Nielsen, J. Otero, M. Papadakis, 2010 .

Yeast Biological Networks Unfold the Interplay of Antioxidants, Genome and Phenotype, and Reveal a Novel Regulator of the Oxidative Stress Response

J. Nielsen, J. Otero, M. Papadakis, 2010, PloS one.

Evaluation of Readily Accessible Azoles as Mimics of the Aromatic Ring of D‐Phenylalanine in the Turn Region of Gramicidin S

H. Overkleeft, H. Busscher, J. Otero, 2011, ChemMedChem.

Adsorption of Pharmaceutical Pollutants from Water Using Covalent Organic Frameworks.

B. Espiña, J. Otero, D. Medina, 2018, Chemistry.

Bisphosphine-functionalized cyclic decapeptides based on the natural product Gramicidin S: a potential scaffold for transition-metal coordination.

K. Lammertsma, J. Otero, M. V. van Raaij, 2009, Chemistry.

Non-invasive Physiology in Conscious Mice

J. Otero, I. Amende, T. Hampton, 2004, Alternatives to laboratory animals : ATLA.

Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct.

J. Otero, A. Hawkins, C. González‐Bello, 2015, Journal of the American Chemical Society.

6-Deoxyhexoses from l-Rhamnose in the Search for Inducers of the Rhamnose Operon: Synergy of Chemistry and Biotechnology.

Ciaran L. Kelly, J. Otero, M. Wormald, 2016, Chemistry.

'Inverted' analogs of the antibiotic gramicidin S with an improved biological profile.

H. Overkleeft, G. A. van der Marel, J. Otero, 2012, Bioorganic & medicinal chemistry.

Exploring the conformational and biological versatility of β-turn-modified gramicidin S by using sugar amino acid homologues that vary in ring size.

H. Overkleeft, G. A. van der Marel, A. W. Tuin, 2011, Chemistry.

Gramicidin S derivatives containing cis- and trans-morpholine amino acids (MAAs) as turn mimetics.

H. Overkleeft, G. A. van der Marel, J. Otero, 2010, Chemistry.

Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues.

H. Overkleeft, G. A. van der Marel, H. Busscher, 2009, Bioorganic & medicinal chemistry.

Mycobacterium tuberculosis shikimate kinase inhibitors: design and simulation studies of the catalytic turnover.

J. Otero, A. Hawkins, C. González‐Bello, 2013, Journal of the American Chemical Society.

A Nitro Sugar‐Mediated Stereocontrolled Synthesis of β2‐Amino Acids: Synthesis of a Polyhydroxylated trans‐2‐Aminocyclohexanecarboxylic Acid

J. Otero, R. Nash, J. Estévez, 2012 .

Studies on the Michael addition of naphthoquinones to sugar nitro olefins: first synthesis of polyhydroxylated hexahydro-11H-benzo[a]carbazole-5,6-diones and hexahydro-11bH-benzo[b]carbazole-6,11-diones

J. Otero, C. Salas, J. Estévez, 2012 .

Method for non-invasively recording electrocardiograms in conscious mice

Victor Chu, J. Otero, I. Amende, 2001, BMC Physiology.

Preliminary Studies on the Michael Addition of Quinones to Nitroolefins: (6bR,10aS)-7,8,9,10,10a,11-Hexahydro-6bH-benzo[a]carbazole-5,6-diones, (4aR,11bS)-1,2,3,4,4a,5-Hexahydro-11bH-benzo[b]carbazole-6,11-diones, and 1,2,3,4-Tetrahydro-5H-benzo[b]carbazole-6,11-diones

J. Otero, J. Estévez, R. J. Estévez, 2007 .

Preliminary studies on the synthesis of rancinamycins from nitrosugars: first total synthesis of (3S,4S,5S,6R)-5-benzyloxy-6-hydroxy-3,4-(isopropylidendioxy)-cyclohex-1-enecarbaldehyde

J. Otero, J. Estévez, R. J. Estévez, 2005 .

Preliminary studies on a novel synthesis of β-amino acids: stereocontrolled transformation of d- and l-glyceraldehyde into 3-amino-2-(2′,2′-dimethyl-1′,3′-dioxolan-4′-yl)propanoic acids

J. Otero, J. Estévez, R. J. Estévez, 2006 .

Preliminary studies on the incorporation of sugars into naphthoquinones: synthesis of (1R,2S,3S,4R,4aS,11bS)-2-(benzyloxy)-1,2,3,4,4a,5-hexahydro-1,3,4-trihydroxy-11bH-benzo[b]carbazole-6,11-dione

J. Otero, J. Estévez, R. J. Estévez, 2005 .

Preliminary studies on the transformation of nitrosugars into branched chain iminosugars: synthesis of 1,4-dideoxy-4-C-hydroxymethyl-1,4-imino-pentanols.

J. Otero, R. Soengas, D. Watkin, 2007, Organic letters.

Design, synthesis and structural analysis of mixed α/β-peptides that adopt stable cyclic hairpin-like conformations

H. Overkleeft, H. Busscher, J. Otero, 2012 .

Highly functionalized cyclic and bicyclic β−amino acids from sugar β−nitroesters

J. Otero, Amalia Estévez, G. Fleet, 2020, Tetrahedron.

On‐Line Purification of Monoclonal Antibodies Using an Integrated Stirred‐Tank Reactor/Expanded‐Bed Adsorption System

J. Otero, I. Yamato, R. Ohashi, 2002, Biotechnology progress.

Structure of the Receptor-Binding Carboxy-Terminal Domain of the Bacteriophage T5 L-Shaped Tail Fibre with and without Its Intra-Molecular Chaperone

J. Otero, J. Castón, D. Luque, 2015, Viruses.

Understanding the Key Factors that Control the Inhibition of Type II Dehydroquinase by (2R)‐2‐Benzyl‐3‐dehydroquinic Acids

J. Otero, F. Gago, A. Hawkins, 2010, ChemMedChem.

Studies on the transformation of nitrosugars into iminosugars III: synthesis of (2R,3R,4R,5R,6R)-2-(hydroxymethyl)azepane-3,4,5,6-tetraol and (2R,3R,4R,5R,6S)-2-(hydroxymethyl)azepane-3,4,5,6-tetraol

J. Otero, R. Soengas, Amalia Estévez, 2010 .

Studies on the transformation of nitrosugars into branched chain iminosugars. Part II: Synthesis of (3R,4R,5R,6S)-2,2-bis(hydroxymethyl)azepane-3,4,5,6-tetraol

J. Otero, R. Soengas, Amalia Estévez, 2008 .

On a possible neutral charge state for the catalytic dyad in β-secretase when bound to hydroxyethylene transition state analogue inhibitors.

Fredy Sussman, Marian Castro, Lucía González-Louro, 2011, Journal of medicinal chemistry.

Insights into substrate binding and catalysis in bacterial type I dehydroquinase.

J. Otero, A. Hawkins, C. González‐Bello, 2014, The Biochemical journal.

Quinate-based ligands for irreversible inactivation of the bacterial virulence factor DHQ1 enzyme—A molecular insight

J. Otero, A. Hawkins, C. González‐Bello, 2023, Frontiers in Molecular Biosciences.

Novel micro‐bioreactor high throughput technology for cell culture process development: Reproducibility and scalability assessment of fed‐batch CHO cultures

Ashraf Amanullah, M. Mikola, J. Otero, 2010, Biotechnology and bioengineering.

An adamantyl amino acid containing gramicidin S analogue with broad spectrum antibacterial activity and reduced hemolytic activity.

H. Overkleeft, G. A. van der Marel, J. Otero, 2010, Chemistry.

Hypoglycemic activity of several seaweed extracts.

J. Otero, J. Calleja, M. Lamela, 1989, Journal of ethnopharmacology.

Biochemical and Structural Characterization of a novel thermophilic esterase EstD11 provide catalytic insights for the HSL family

J. Otero, M. González-Siso, J. Hermoso, 2021, Computational and structural biotechnology journal.

Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction

Mark J van Raaij, Liang Tong, Torsten Schwede, 2011, Proteins.

Synthetic Chemical Inducers and Genetic Decoupling Enable Orthogonal Control of the rhaBAD Promoter.

Atsushi Kato, Ciaran L. Kelly, John T Heap, 2016, ACS synthetic biology.

Evolutionary engineering of Saccharomyces cerevisiae for efficient aerobic xylose consumption.

Jens Nielsen, Lisbeth Olsson, T. Jeffries, 2012, FEMS yeast research.

Genome-scale modeling enables metabolic engineering of Saccharomyces cerevisiae for succinic acid production

Rasmus Agren, J. Nielsen, Rasmus Agren, 2013, Journal of Industrial Microbiology & Biotechnology.

Synthesis and evaluation of strand and turn modified ring-extended gramicidin S derivatives.

H. Overkleeft, J. Otero, P. Nibbering, 2011, Bioorganic & medicinal chemistry.

Fueling industrial biotechnology growth with bioethanol.

Lisbeth Olsson, Gianni Panagiotou, J. Otero, 2007, Advances in biochemical engineering/biotechnology.

Inhibiting and reversing amyloid-β peptide (1-40) fibril formation with gramicidin S and engineered analogues.

J. Abrahams, J. Otero, A. Gräslund, 2013, Chemistry.

Linking Genotype and Phenotype of Saccharomyces cerevisiae Strains Reveals Metabolic Engineering Targets and Leads to Triterpene Hyper-Producers

Jens Nielsen, Gianni Panagiotou, J. Otero, 2011, PloS one.

Exploring the water-binding pocket of the type II dehydroquinase enzyme in the structure-based design of inhibitors.

J. Otero, A. Hawkins, C. González‐Bello, 2014, Journal of medicinal chemistry.

Mechanistic basis of the inhibition of type II dehydroquinase by (2S)- and (2R)-2-benzyl-3-dehydroquinic acids.

J. Otero, A. Hawkins, C. González‐Bello, 2013, ACS chemical biology.

Irreversible covalent modification of type I dehydroquinase with a stable Schiff base.

J. Otero, A. Hawkins, C. González‐Bello, 2015, Organic & biomolecular chemistry.

Effect of the protonation state of the titratable residues on the inhibitor affinity to BACE-1.

Erik Lindström, Fredy Sussman, Susanne Nyström, 2010, Biochemistry.

High-resolution structures of Thermus thermophilus enoyl-acyl carrier protein reductase in the apo form, in complex with NAD+ and in complex with NAD+ and triclosan.

J. Otero, A. Pingoud, M. V. van Raaij, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Inhibiting and reversing Aβ peptide (1-40) fibril formation by gramicidin S and engineered analogues

J. Abrahams, J. Otero, A. Gräslund, 2014 .

Adsorption of Pharmaceutical Pollutants from Water Using Covalent Organic Frameworks.

B. Espiña, J. Otero, D. Medina, 2018, Chemistry.

Determination of monoclonal antibody production in cell culture using novel microfluidic and traditional assays

J. Otero, Jean-François P Hamel, Ryo Ohashi, 2002, Electrophoresis.

Evaluation of Readily Accessible Azoles as Mimics of the Aromatic Ring of D‐Phenylalanine in the Turn Region of Gramicidin S

H. Overkleeft, H. Busscher, J. Otero, 2011, ChemMedChem.

An adamantyl amino acid containing gramicidin S analogue with broad spectrum antibacterial activity and reduced hemolytic activity.

H. Overkleeft, G. A. van der Marel, J. Otero, 2010, Chemistry.

Tetrahydrobenzothiophene Derivatives: Conformationally Restricted Inhibitors of Type II Dehydroquinase

J. Otero, A. Hawkins, C. González‐Bello, 2011, ChemMedChem.

Whole genome sequencing of Saccharomyces cerevisiae: from genotype to phenotype for improved metabolic engineering applications

J. Nielsen, L. Farinelli, J. Otero, 2010, BMC Genomics.

Hydroxylammonium derivatives for selective active-site lysine modification in the anti-virulence bacterial target DHQ1 enzyme

J. Otero, A. Hawkins, C. González‐Bello, 2019 .