K. Bleicher

发表

Parallel solution- and solid-phase synthesis of spiropyrrolo-pyrroles as novel neurokinin receptor ligands.

K. Bleicher, Yves Wuethrich, G. Adam, 2002, Bioorganic & medicinal chemistry letters.

Benzodioxoles: novel cannabinoid-1 receptor inverse agonists for the treatment of obesity.

Wolfgang Guba, Gisbert Schneider, Jochem Alsenz, 2008, Journal of medicinal chemistry.

New phenylfluorenyl based linkers for solid phase synthesis

K. Bleicher, Yves Wuethrich, C. Lutz, 2000 .

Functionalized Proline-Rich Peptides Bind the Bacterial Second Messenger c-di-GMP.

K. Bleicher, U. Jenal, H. Mauser, 2018, Angewandte Chemie.

Analysis of double-stranded oligonucleotides by electrospray mass spectrometry.

K. Bleicher, H. Gaus, E. Bayer, 1994, Analytical chemistry.

Solid-phase Suzuki cross-coupling reactions using a phosphine ligand based on a phospha-adamantane framework

Stephan A. Ohnmacht, K. Bleicher, J. McNulty, 2004 .

Growth inhibition of pancreatic tumor cells by modified antisense oligodeoxynucleotides

K. Bleicher, H. Kalthoff, B. Kremer, 1998, Langenbeck's Archives of Surgery.

Design and Synthesis of Nucleoproline Amino Acids for the Straightforward Preparation of Chiral and Conformationally Constrained Nucleopeptides

K. Bleicher, H. Wennemers, Rolf A. Kramer, 2012 .

Parallel solution- and solid-phase synthesis of spirohydantoin derivatives as neurokinin-1 receptor ligands.

K. Bleicher, Yves Wuethrich, T. Hoffmann, 2002, Bioorganic & medicinal chemistry letters.

Selective oxytocin receptor activation prevents prefrontal circuit dysfunction and social behavioral alterations in response to chronic prefrontal cortex activation in rats

K. Bleicher, F. Knoflach, C. Grundschober, 2022, bioRxiv.

Investigating discovery strategies and pharmacological properties of stereodefined phosphorodithioate LNA gapmers

K. Bleicher, J. Wengel, T. Koch, 2022, Molecular therapy. Nucleic acids.

Analysis of the FHIT gene and its product in squamous cell carcinomas of the head and neck

K. Bleicher, T. Goodrow, S. C. Liu, 1998, Oncogene.

Ligand identification for G-protein-coupled receptors: a lead generation perspective.

Rainer E. Martin, Konrad H Bleicher, Luke G Green, 2004, Current opinion in chemical biology.

Solid Phase Synthesis of β-Peptides via Arndt-Eistert Homologation of Fmoc-Protected Amino Acid Diazoketones

K. Bleicher, K. Bair, R. Marti, 1997 .

Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties.

B. Kuhn, M. Rudolph, K. Bleicher, 2011, Bioorganic & medicinal chemistry letters.

Parallel synthesis of substituted imidazoles from 1,2-aminoalcohols

K. Bleicher, Yves Wuethrich, A. Alanine, 2002 .

Alkyl diphenylacetyl, 9H-xanthene- and 9H-thioxanthene-carbonyl carbamates as positive allosteric modulators of mGlu1 receptors.

T. Woltering, K. Bleicher, V. Mutel, 2002, Farmaco.

PhFl polystyrene: A new resin for solid phase organic synthesis

K. Bleicher, J. Wareing, 1998 .

A guide to drug discovery: Hit and lead generation: beyond high-throughput screening

Hans-Joachim Böhm, Klaus Müller, Konrad H. Bleicher, 2003, Nature Reviews Drug Discovery.

Diffusion Edited NMR: Screening Compound Mixtures by Affinity NMR to Detect Binding Ligands to Vancomycin

K. Bleicher, James R. Wareing, Konrad H. Bleicher, 1998 .

In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3′ and 5′ thiophosphate linkages

K. Bleicher, J. Wengel, H. Hansen, 2019, Nucleic acids research.

Studies in mice, hamsters, and rats demonstrate that repression of hepatic apoA-I expression by taurocholic acid in mice is not mediated by the farnesoid-X-receptor

Hans Richter, Martin Ebeling, Konrad Bleicher, 2011, Journal of Lipid Research.

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

R. Seeley, D. Drucker, P. Pfluger, 2014, Nature Medicine.

Analysis of oligonucleotides using coupled high performance liquid chromatography-electrospray mass spectrometry

K. Bleicher, E. Bayer, 1994 .

Various factors influencing the signal intensity of oligonucleotides in electrospray mass spectrometry.

K. Bleicher, E. Bayer, Ernst Bayer, 1994, Biological mass spectrometry.

Enzymatic degradation of various antisense oligonucleotides: monitoring and fragment identification by MECC and ES-MS.

K. Bleicher, H. Kalthoff, E. Bayer, 1995, Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity.

Development of a virtual screening method for identification of "frequent hitters" in compound libraries.

Wolfgang Guba, Petra Schneider, Gisbert Schneider, 2002, Journal of medicinal chemistry.

Propensities of Fatty Acid-Modified ASOs: Self-Assembly vs Albumin Binding.

M. Lauer, K. Bleicher, S. Huber, 2023, Bioconjugate chemistry.

Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist.

Hans Richter, Rainer E. Martin, Rainer E Martin, 2009, Bioorganic & medicinal chemistry letters.

Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes.

Franz Schuler, Rainer E. Martin, Rainer E Martin, 2011, Bioorganic & medicinal chemistry letters.

Chemogenomics: bridging a drug discovery gap.

K. Bleicher, Konrad H Bleicher, 2002, Current medicinal chemistry.

Multipin solid-phase synthesis of biaryls via Suzuki cross coupling reaction of aryltriflates

K. Bleicher, C. Lutz, 2002 .