G. Adam

发表

Parallel solution- and solid-phase synthesis of spiropyrrolo-pyrroles as novel neurokinin receptor ligands.

K. Bleicher, Yves Wuethrich, G. Adam, 2002, Bioorganic & medicinal chemistry letters.

Mutational Analysis and Molecular Modeling of the Allosteric Binding Site of a Novel, Selective, Noncompetitive Antagonist of the Metabotropic Glutamate 1 Receptor*

J. Kew, G. Adam, P. Malherbe, 2003, The Journal of Biological Chemistry.

Asymmetric Synthesis and Receptor Pharmacology of the Group II mGlu Receptor Ligand (1S,2R,3R,5R,6S)‐2‐Amino‐3‐hydroxy‐bicyclo[3.1.0]hexane‐2,6‐dicarboxylic Acid—HYDIA

J. Kemp, J. Kew, T. Woltering, 2008, ChemMedChem.

Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists.

J. Kew, T. Woltering, G. Adam, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: new potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1.

T. Woltering, G. Adam, V. Mutel, 2007, Bioorganic & medicinal chemistry letters.

Characterization of [3H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using Semliki Forest virus vectors

T. Woltering, G. Adam, P. Malherbe, 2000, Neuropharmacology.

Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: part 2. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists.

J. Kew, T. Woltering, G. Adam, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and reactions of alkyl- and aryl-substituted metallacyclobutane derivatives of molybdenum and tungsten

Malcolm L. H. Green, G. Adam, M. Ephritikhine, 1980 .

Synthesis of heterocyclic enol ethers and their use as group 2 metabotropic glutamate receptor antagonists.

T. Woltering, G. Adam, V. Mutel, 1999, Bioorganic & medicinal chemistry letters.

Total synthesis of (+)-gloeosporone: assignment of absolute configuration

G. Adam, D. Seebach, R. Zibuck, 1987 .

Gloeosporone – A Macrolide Fungal Germination Self‐Inhibitor Total Synthesis and Activity

W. L. Meyer, J. F. Hinton, G. Adam, 1989 .

Total Synthesis of Myxovirescins, 1 Strategy and Construction of the “Southeastern” Part [O(1)–C(14)]

S. Hintermann, G. Adam, D. Seebach, 1994 .

Scope and limitations of the TiCl4‐mediated additions of isocyanides to aldehydes and ketones with formation of α‐hydroxycarboxylic acid amides

G. Adam, D. Seebach, W. Weigand, 1988 .

High-affinity, non-peptide agonists for the ORL1 (orphanin FQ/nociceptin) receptor.

F. Monsma, G. Adam, A. Cesura, 2000, Journal of medicinal chemistry.

Scope and Limitations of the TiCl4‐Mediated Additions of Isocyanides to Aldehydes and Ketones with Formation of α‐Hydroxycarboxylic Acid Amides.

G. Adam, D. Seebach, W. Weigand, 1988 .

Structure-activity relationships of substituted 5H-thiazolo[3,2-a]pyrimidines as group 2 metabotropic glutamate receptor antagonists.

T. Woltering, G. Adam, V. Mutel, 1999, Bioorganic & medicinal chemistry letters.

A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.

G. Adam, Gavin Kilpatrick, K. Lundstrom, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis of (1S,3aS)-8-(2,3,3a,4,5, 6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4. 5]decan-4-one, a potent and selective orphanin FQ (OFQ) receptor agonist with anxiolytic-like properties.

G. Adam, M. Hennig, A. Cesura, 2000, European journal of medicinal chemistry.

Novel hexahydrospiro[piperidine-4,1'-pyrrolo[3,4-c]pyrroles]: highly selective small-molecule nociceptin/orphanin FQ receptor agonists.

G. Adam, M. Hennig, A. Cesura, 2003, Journal of medicinal chemistry.

Bis(η-alkylcyclopentadienyl)-molybdenum and -tungsten chemistry: mixed valence, ambidentate tetraoxo- and tetrathio-molybdato and -tungstato derivatives, and related dihydrido and dichloro compounds

Malcolm L. H. Green, G. Adam, 1981 .

Synthesis of (1S,3aS)-8- (2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro [4.5]decan-4-one, a Potent and Selective Orphanin FQ (OFQ) Receptor Agonist with Anxiolytic-Like Properties.

G. Adam, M. Hennig, A. Cesura, 2000 .

Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent

S. Nakanishi, J. Kemp, J. Kew, 2004, Neuropharmacology.

Characterization of [3H]‐(2S,2′R,3′R)‐2‐(2′,3′‐dicarboxy‐ cyclopropyl)glycine ([3H]‐DCG IV) binding to metabotropic mGlu2 receptor‐transfected cell membranes

F. Monsma, J. Kemp, G. Adam, 1998, British journal of pharmacology.

Characterization of [3H]Quisqualate Binding to Recombinant Rat Metabotropic Glutamate 1a and 5a Receptors and to Rat and Human Brain Sections

R. Faull, G. Adam, P. Malherbe, 2000, Journal of neurochemistry.

Characterization of (2S,2′R,3′R)‐2‐(2′,3′‐[3H]‐Dicarboxycyclopropyl)glycine Binding in Rat Brain

J. Kemp, T. Woltering, G. Adam, 1998, Journal of neurochemistry.

Multiple pathways for regulation of the KCl-induced [3H]-GABA release by metabotropic glutamate receptors, in primary rat cortical cultures

J. Kemp, G. Adam, V. Mutel, 1998, Brain Research.

EPC‐synthesis and fungistatic activity of a gloeosporone analog with an ω‐hydroxybutyl instead of the pentyl side chain on the macrocyclic ring

G. Adam, D. Seebach, U. Gisi, 1990 .

EPC‐Synthesis and Fungistatic Activity of a Gloeosporone Analogue with an ω‐Hydroxybutyl Instead of the Pentyl Side Chain on the Macrocyclic Ring.

G. Adam, D. Seebach, U. Gisi, 1991 .

Ro 64-6198 [(1S,3aS)-8-(2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one] Acts Differently from Nociceptin/Orphanin FQ in Rat Periaqueductal Gray Slices

G. Adam, L. Chiou, J. Wichmann, 2004, Journal of Pharmacology and Experimental Therapeutics.

Influence of the selective ORL1 receptor agonist, Ro64-6198, on rodent neurological function

G. Higgins, A. Grottick, G. Adam, 2001, Neuropharmacology.

A combined pharmacological and genetic approach to investigate the role of orphanin FQ in learning and memory

A. Grottick, G. Adam, H. Takeshima, 2002, The European journal of neuroscience.

A Short and Efficient Synthesis of (2S,2′R,3′R)-2-(2′,3′-Dicarboxylcyclopropyl)glycine (DCG-IV)

G. Adam, J. Wichmann, 1999 .

8-acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as orphanin FQ receptor agonists.

G. Adam, A. Cesura, S. Röver, 1999, Bioorganic & medicinal chemistry letters.

Structure—Activity Relationships of Substituted 5H‐Thiazolo[3,2‐a]pyrimidines as Group 2 Metabotropic Glutamate Receptor Antagonists.

T. Woltering, G. Adam, V. Mutel, 1999 .

Identification of essential residues involved in the glutamate binding pocket of the group II metabotropic glutamate receptor.

J. Kemp, G. Adam, P. Malherbe, 2001, Molecular pharmacology.

ORL1 receptor ligands: structure-activity relationships of 8-cycloalkyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-ones.

G. Adam, A. Cesura, S. Röver, 2000, Bioorganic & medicinal chemistry letters.

A Highly Convergent Total Synthesis of (+)‐Myxovirescine M2. Preliminary Communication

G. Adam, D. Seebach, M. Maestro, 1991 .