D. Douguet

发表

Ligand-Based Approaches in Virtual Screening

D. Douguet, 2008 .

Easier threading through web-based comparisons and cross-validations

Dominique Douguet, Gilles Labesse, G. Labesse, 2001, Bioinform..

Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition*

D. Douguet, G. Mourier, D. Servent, 2015, The Journal of Biological Chemistry.

LEA3D: a computer-aided ligand design for structure-based drug design.

G. Labesse, H. Munier-Lehmann, S. Pochet, 2005, Journal of medicinal chemistry.

Black mamba venom peptides target acid-sensing ion channels to abolish pain

Dominique Douguet, Miguel Salinas, Eric Lingueglia, 2012, Nature.

Computational analysis of calculated physicochemical and ADMET properties of protein-protein interaction inhibitors

Dominique Douguet, David Lagorce, Bruno O. Villoutreix, 2017, Scientific Reports.

Functional characterization of the AFF (AF4/FMR2) family of RNA-binding proteins: insights into the molecular pathology of FRAXE intellectual disability.

J. Gécz, D. Douguet, Mireille Melko, 2011, Human molecular genetics.

Structure and function of polycystins: insights into polycystic kidney disease

D. Douguet, E. Honoré, Amanda Patel, 2019, Nature Reviews Nephrology.

Inhibition of Patched Drug Efflux Increases Vemurafenib Effectiveness against Resistant BrafV600E Melanoma

D. Douguet, C. Bertolotto, V. Biou, 2020, Cancers.

A bedside index assessing the reliability of pulmonary artery occlusion pressure measurements during mechanical ventilation with positive end-expiratory pressure

C. Brun-Buisson, D. Douguet, O. Axler, 1992 .

Group X Secreted Phospholipase A2 Proenzyme Is Matured by a Furin-like Proprotein Convertase and Releases Arachidonic Acid inside of Human HEK293 Cells*

M. Gelb, D. Douguet, S. Scarzello, 2011, The Journal of Biological Chemistry.

minimal or no injury to the lung microvascular barrier Chronic interleukin-2 treatment in awake sheep causes

D. Douguet, N. Staub, E. H. Jerome, 2015 .

Chronic interleukin-2 treatment in awake sheep causes minimal or no injury to the lung microvascular barrier.

D. Douguet, N. Staub, E. H. Jerome, 1996, Journal of applied physiology.

Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists.

D. Douguet, J. Cazareth, E. Lalli, 2009, The Journal of clinical endocrinology and metabolism.

Identification of Tazarotenic Acid as the First Xenobiotic Substrate of Human Retinoic Acid Hydroxylase CYP26A1 and CYP26B1

D. Douguet, A. Zelter, N. Isoherranen, 2016, The Journal of Pharmacology and Experimental Therapeutics.

D OCKGROUND resource for studying protein–protein interfaces

I. Vakser, D. Douguet, A. Tovchigrechko, 2006 .

Role of the arterial chemoreceptors in ventilatory and circulatory adjustments to hypoxia in awake Pekin ducks

D. Douguet, P. Sébert, P. Bouverot, 1979, Journal of comparative physiology.

TWIK1, a unique background channel with variable ion selectivity

D. Douguet, S. Bendahhou, J. Barhanin, 2012, Proceedings of the National Academy of Sciences.

The pleckstrin homology domain of phospholipase Cbeta transmits enzymatic activation through modulation of the membrane-domain orientation.

D. Douguet, G. Drin, S. Scarlata, 2006, Biochemistry.

Quantitative structure‐activity relationship studies of RAR α, β, γ retinoid agonists

D. Douguet, G. Grassy, E. Thoreau, 1999 .

Channels 2P Molecular Physiology of pH-Sensitive Background K

D. Bayliss, D. Douguet, M. Larroque, 2015 .

Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity.

H. Munier-Lehmann, S. Pochet, D. Douguet, 2008, Bioorganic & medicinal chemistry.

Comparison of the ligand binding site of CYP2C8 with CYP26A1 and CYP26B1: a structural basis for the identification of new inhibitors of the retinoic acid hydroxylases

D. Douguet, P. Diaz, R. Foti, 2016, Journal of enzyme inhibition and medicinal chemistry.

Piezo Ion Channels in Cardiovascular Mechanobiology.

D. Douguet, A. Xu, E. Honoré, 2019, Trends in pharmacological sciences.

HELIQUEST : a web server to screen sequences with specific α-helical properties

Dominique Douguet, Romain Gautier, Bruno Antonny, 2008 .

Nucleoside Analogues as Inhibitors of Thymidylate Kinases: Possible Therapeutic Applications

G. Labesse, H. Munier-Lehmann, S. Pochet, 2002, Chembiochem : a European journal of chemical biology.

Exploring Acyclic Nucleoside Analogues as Inhibitors of Mycobacterium tuberculosis Thymidylate Kinase

H. Munier-Lehmann, L. Rigouts, D. Douguet, 2008, ChemMedChem.

HELIQUEST: a web server to screen sequences with specific alpha-helical properties

Dominique Douguet, Romain Gautier, Bruno Antonny, 2008, Bioinform..

Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities

J. Pawlotsky, D. Douguet, W. Bourguet, 2016, Nature Communications.

Stability of the Plasmodium falciparum AMA1-RON2 Complex Is Governed by the Domain II (DII) Loop

Roberto F. Delgadillo, D. Douguet, S. McGowan, 2016, PloS one.

Computational and biophysical approaches to protein–protein interaction inhibition of Plasmodium falciparum AMA1/RON2 complex

Dominique Douguet, Emilie Pihan, Roberto F. Delgadillo, 2015, Journal of Computer-Aided Molecular Design.

Host Cell Invasion by Apicomplexan Parasites: Insights from the Co-Structure of AMA1 with a RON2 Peptide

D. Douguet, Magali Roques, M. Pugnière, 2011, Science.

Data Sets Representative of the Structures and Experimental Properties of FDA-Approved Drugs.

Dominique Douguet, D. Douguet, 2018, ACS medicinal chemistry letters.

Plasmodium falciparum CTP:phosphocholine cytidylyltransferase possesses two functional catalytic domains and is inhibited by a CDP‐choline analog selected from a virtual screening

H. Vial, D. Douguet, K. Wengelnik, 2015, FEBS letters.

Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels

D. Douguet, E. Honoré, 2019, Cell.

Sheep lung as xenograft oxygenator of human blood: An ex vivo study

T. Waldmann, A. Pavie, D. Douguet, 1995 .

Binding Site and Inhibitory Mechanism of the Mambalgin-2 Pain-relieving Peptide on Acid-sensing Ion Channel 1a*

D. Douguet, M. Salinas, Thomas Besson, 2014, The Journal of Biological Chemistry.

DOCKGROUND resource for studying protein-protein interfaces

Dominique Douguet, Huei-Chi Chen, Andrey Tovchigrechko, 2006, Bioinform..

e-LEA3D: a computational-aided drug design web server

Dominique Douguet, D. Douguet, 2010, Nucleic Acids Res..

Incidence of vascular complications in kidney transplantation: is there any interference with the nature of the perfusion solution?

D. Douguet, H. Bensadoun, B. Charpentier, 1994, Clinical transplantation.

Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers

D. Douguet, G. Drin, B. Antonny, 2011, The Journal of cell biology.

Diacylglyceride kinases, sphingosine kinases and NAD kinases: distant relatives of 6-phosphofructokinases.

Dominique Douguet, Gilles Labesse, G. Labesse, 2002, Trends in biochemical sciences.

Silencing of the Tandem Pore Domain Halothane-inhibited K+ Channel 2 (THIK2) Relies on Combined Intracellular Retention and Low Intrinsic Activity at the Plasma Membrane*

D. Douguet, M. Larroque, F. Lesage, 2013, The Journal of Biological Chemistry.

Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue

M. Lazdunski, D. Douguet, F. Lesage, 2009, Proceedings of the National Academy of Sciences.

SENSAAS (SENsitive Surface As A Shape): utilizing open-source algorithms for 3D point cloud alignment of molecules

Dominique Douguet, Fr'ed'eric Payan, D. Douguet, 2019, 1908.11267.

Effects of catecholamines on the pulmonary venous bed in sheep.

D. Douguet, C. Richard, J. Teboul, 1998, Critical care medicine.

Comparison of indirect calorimetry and thermodilution cardiac output measurement in children.

D. Douguet, A. Capderou, M. Zelter, 1997, American journal of respiratory and critical care medicine.

e-Drug3D: 3D structure collections dedicated to drug repurposing and fragment-based drug design

Lionel Colliandre, Dominique Douguet, Emilie Pihan, 2012, Bioinform..

The Adsorption of Argon and Nitrogen in Silicalite-1 Zeolite: A Grand Canonical Monte-Carlo study

D. Douguet, A. Fuchs, R. Pellenq, 1996 .

A genetic algorithm for the automated generation of small organic molecules: Drug design using an evolutionary algorithm

Dominique Douguet, Etienne Thoreau, Gérard Grassy, 2000, J. Comput. Aided Mol. Des..

Nucleoside Analogues as Inhibitors of Thymidylate Kinases: Possible Therapeutic Applications.

G. Labesse, H. Munier-Lehmann, S. Pochet, 2002 .

A New Family of Inhibitors of Mycobacterium Tuberculosis Thymidine Monophosphate Kinase

H. Munier-Lehmann, S. Pochet, D. Douguet, 2007, Nucleosides, nucleotides & nucleic acids.

From Molecular Modeling to Drug Design

Vincent Catherinot, Gilles Labesse, Martin Cohen-Gonsaud, 2008 .

Pharmacological activation of PIEZO1 in human red blood cells prevents Plasmodium falciparum invasion

M. Abkarian, D. Douguet, K. Wengelnik, 2021, bioRxiv.

Mambalgin-1 pain-relieving peptide locks the hinge between α4 and α5 helices to inhibit rat acid-sensing ion channel 1a

D. Douguet, D. Servent, M. Salinas, 2021, Neuropharmacology.

Time course of muscular blood metabolites during forearm rhythmic exercise in hypoxia.

D. Douguet, P. Legros, A. Capderou, 1986, Journal of applied physiology.

Study of kidney and liver viability in the rat after exclusive aortic perfusion using intracellular ATP measurement

D. Douguet, L. Chiche, H. Bittard, 2004, Urological research.

DOCKGROUND system of databases for protein recognition studies: Unbound structures for docking

Dominique Douguet, Andrey Tovchigrechko, Ying Gao, 2007, Proteins.

Biochemical characterization of Plasmodium falciparum CTP:phosphoethanolamine cytidylyltransferase shows that only one of the two cytidylyltransferase domains is active.

H. Vial, D. Douguet, K. Wengelnik, 2013, The Biochemical journal.

The Pleckstrin Homology Domain of Phospholipase C β Transmits Enzymatic Activation through Modulation of Membrane - Domain Orientation

D. Douguet, G. Drin, S. Scarlata, 2008 .

sensaas: Shape‐based Alignment by Registration of Colored Point‐based Surfaces

Dominique Douguet, Frédéric Payan, D. Douguet, 2020, Molecular informatics.

HELIQUEST: a web server to screen sequences with specific alpha-helical properties

D. Douguet, G. Drin, R. Gautier, 2008, Bioinform..

From sequence to structure to function: a case study

G. Labesse, H. Munier-Lehmann, D. Douguet, 2002 .

1184 FRAGMENT BASED DRUG DISCOVERY OF NEW CYCLOPHILIN INHIBITORS UNRELATED TO CYCLOSPORINE A THAT POTENTLY INHIBIT HCV REPLICATION

J. Pawlotsky, D. Douguet, P. Barthe, 2013 .

Large-Scale Structural Modeling of protein complexes at Low Resolution

Ying Gao, Dominique Douguet, Andrey Tovchigrechko, 2008, J. Bioinform. Comput. Biol..

Comparative modelling and immunochemical reactivity of Escherichia coli UMP kinase.

G. Labesse, H. Sakamoto, A. Gilles, 2002, Biochemical and biophysical research communications.

Silencing of the Tandem Pore Domain Halothane-inhibited K+ Channel 2 (THIK2) Relies on Combined Intracellular Retention and Low Intrinsic Activity at the Plasma Membrane*

D. Douguet, F. Lesage, F. Chatelain, 2013, Journal of Biological Chemistry.