K. Welsh

发表

Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia.

L. Ellerby, John Calvin Reed, S. Krajewski, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins

J. Reed, M. Walters, K. Welsh, 2014, Journal of biomolecular screening.

Bifunctional apoptosis inhibitor (BAR) protects neurons from diverse cell death pathways

J. Reed, John Calvin Reed, S. Krajewski, 2003, Cell Death and Differentiation.

Peptides Targeting Caspase Inhibitors*

John Calvin Reed, K. Welsh, W. Arap, 2003, The Journal of Biological Chemistry.

Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth.

John Calvin Reed, S. Krajewski, M. Krajewska, 2000, Neoplasia.

Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.

John Calvin Reed, K. Welsh, K. Vuori, 2013, Bioorganic & medicinal chemistry letters.

Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.

John Calvin Reed, K. Welsh, K. Vuori, 2011, Bioorganic & medicinal chemistry letters.

Novel X-linked inhibitor of apoptosis protein inhibitors as probes of apoptosis in biology and medicine

J. Reed, K. Welsh, J. An, 2011, Experimental biology and medicine.

Binding Properties of the C‐terminal Domain of VIAF

William H. Bisson, John Calvin Reed, K. Welsh, 2008, Chemical biology & drug design.

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.

Clemencia Pinilla, Kate Welsh, Adel Nefzi, 2004, Cancer cell.

Cellular, Biochemical, and Genetic Analysis of Mechanism of Small Molecule IAP Inhibitors*

Clemencia Pinilla, Kate Welsh, Michael Cuddy, 2004, Journal of Biological Chemistry.

Distinct BIR Domains of cIAP1 Mediate Binding to and Ubiquitination of Tumor Necrosis Factor Receptor-associated Factor 2 and Second Mitochondrial Activator of Caspases*

John Calvin Reed, J. Zapata, K. Welsh, 2006, Journal of Biological Chemistry.

Molecular basis for CD 40 signaling mediated by TRAF 3

Hao Wu, C. Ni, K. R. Ely, 2000 .

LMP 1 PROTEIN FROM THE EPSTEIN BARR VIRUS IS A STRUCTURAL CD 40 DECOY IN B LYMPHOCYTES FOR BINDING TO TRAF 3 *

C. Ni, K. R. Ely, John Calvin Reed, 2005 .

The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation.

A. Godzik, John Calvin Reed, S. Krajewski, 2003, The Biochemical journal.

Modulates Innate Immune Responses Ubiquitination and a B k Suppresses I B, k Inhibits NF- Salmonella typhimurium of Secreted Factor L Deubiquitinase Salmonella

A. Godzik, John Calvin Reed, M. Loeffler, 2008 .

XIAP mediates NOD signaling via interaction with RIP2

J. B. Garrison, John Calvin Reed, K. Welsh, 2009, Proceedings of the National Academy of Sciences.

Purification and use of recombinant inhibitor of apoptosis proteins as caspase inhibitors.

John Calvin Reed, K. Welsh, Q. Deveraux, 2000, Methods in enzymology.

Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells.

G. Pond, M. Minden, John Calvin Reed, 2005, Blood.

Differential Requirements for Tumor Necrosis Factor Receptor-associated Factor Family Proteins in CD40-mediated Induction of NF-κB and Jun N-terminal Kinase Activation*

K. R. Ely, John Calvin Reed, J. Zapata, 1999, The Journal of Biological Chemistry.

Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis.

T. Kipps, John Calvin Reed, R. Houghten, 2005, Blood.

Small-Molecule IAP Antagonists Sensitize Cancer Cells to TRAIL-Induced Apoptosis: Roles of XIAP and cIAPs

John Calvin Reed, K. Welsh, K. Vuori, 2013, Molecular Cancer Therapeutics.

ARTS and Siah collaborate in a pathway for XIAP degradation.

J. B. Garrison, John Calvin Reed, K. Welsh, 2011, Molecular cell.

Crystallization and preliminary X-ray analysis of the TRAF domain of TRAF3.

Marnie L. Havert, C. Ni, K. R. Ely, 2002, Acta crystallographica. Section D, Biological crystallography.

Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain.

John Calvin Reed, K. Welsh, J. An, 2009, Bioorganic & medicinal chemistry letters.

UvA-DARE ( Digital Academic Repository ) Inhibitors of XIAP sensitize CD 40-activated chronic lymphocytic leukemia cells to CD 95-mediated apoptosis

J. Reed, C. Pinilla, K. Welsh, 2005 .

Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP.

John Calvin Reed, K. Welsh, G. Salvesen, 2013, ACS chemical biology.

Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.

J C Reed, D A Scudiero, D. Scudiero, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Humanin peptide suppresses apoptosis by interfering with Bax activation

John Calvin Reed, K. Welsh, D. Zhai, 2003, Nature.

HBXIP functions as a cofactor of survivin in apoptosis suppression

John Calvin Reed, K. Welsh, S. Matsuzawa, 2003, The EMBO journal.

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

J C Reed, John Calvin Reed, K. Welsh, 1999, The EMBO journal.

An IAP-IAP Complex Inhibits Apoptosis*

John Calvin Reed, K. Welsh, G. Salvesen, 2004, Journal of Biological Chemistry.

Analysis of Apoptosis Protein Expression in Early-Stage Colorectal Cancer Suggests Opportunities for New Prognostic Biomarkers

John Calvin Reed, N. Assa‐Munt, S. Krajewski, 2005, Clinical Cancer Research.

A Novel Enhancer of the Apaf1 Apoptosome Involved in Cytochrome c-dependent Caspase Activation and Apoptosis*

A. Godzik, F. Pio, John Calvin Reed, 2001, The Journal of Biological Chemistry.

Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis

John Calvin Reed, R. Houghten, C. Pinilla, 2016, PloS one.

cIAP1 Localizes to the nuclear compartment and modulates the cell cycle.

John Calvin Reed, J. Zapata, K. Welsh, 2005, Cancer research.

TRAF1 Is a Substrate of Caspases Activated during Tumor Necrosis Factor Receptor-α-induced Apoptosis*

John Calvin Reed, K. Welsh, Q. Deveraux, 2001, The Journal of Biological Chemistry.

A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases*

J C Reed, N Assa-Munt, John Calvin Reed, 1998, The Journal of Biological Chemistry.

TNFR-Associated Factor Family Protein Expression in Normal Tissues and Lymphoid Malignancies

R. Gascoyne, A. Monks, T. Kipps, 2000, The Journal of Immunology.

Ionomycin-activated Calpain Triggers Apoptosis

Oliver Popp, Andreas Holloschi, Tobias A Knoch, 2002, The Journal of Biological Chemistry.

MalignanciesExpression in Normal Tissues and Lymphoid TNFR-Associated Factor Family Protein

Natalie, A. Monks, T. Kipps, 2000 .

Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells.

C. Meijer, John Calvin Reed, R. Houghten, 2007, Blood.

Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein

Clemencia Pinilla, Indrajit Roy, Dinesh Rakheja, 2007, Molecular Cancer Therapeutics.

LMP1 Protein from the Epstein-Barr Virus Is a Structural CD40 Decoy in B Lymphocytes for Binding to TRAF3*

C. Ni, K. R. Ely, John Calvin Reed, 2005, Journal of Biological Chemistry.

Molecular basis for CD40 signaling mediated by TRAF3.

J C Reed, C. Ni, K. R. Ely, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Key Molecular Contacts Promote Recognition of the BAFF Receptor by TNF Receptor-Associated Factor 3: Implications for Intracellular Signaling Regulation1

C. Ni, K. R. Ely, G. Cheng, 2004, The Journal of Immunology.

Receptor-Associated Factor 3: Implications of the BAFF Receptor by TNF Key Molecular Contacts Promote Recognition

K. R. Ely, G. Cheng, John Calvin Reed, 2004 .

Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses.

John Calvin Reed, K. Welsh, J. Damiano, 2004, The Biochemical journal.

TUCAN, an Antiapoptotic Caspase-associated Recruitment Domain Family Protein Overexpressed in Cancer*

A. Godzik, F. Pio, John Calvin Reed, 2001, The Journal of Biological Chemistry.

Anti-CD20 Antibody Rituximab and Anti-CD23 Antibody IDEC-152 Induce Apoptosis of Malignant B-Cells in Combination with Chemical Antagonists of XIAP.

T. Kipps, J. Reed, K. Welsh, 2004 .

XIAP-positive diffuse large B-cell lymphoma cells Small-molecule XIAP antagonist restores caspase-9-mediated apoptosis in

R. Houghten, C. Pinilla, K. Welsh, 2012 .

Vaccinia Virus Protein F1L Is a Caspase-9 Inhibitor*

R. Liddington, John Calvin Reed, K. Welsh, 2009, The Journal of Biological Chemistry.

Salmonella Secreted Factor L Deubiquitinase of Salmonella typhimurium Inhibits NF-κB, Suppresses IκBα Ubiquitination and Modulates Innate Immune Responses1

A. Godzik, John Calvin Reed, M. Loeffler, 2008, The Journal of Immunology.

TR-FRET-Based High-Throughput Screening Assay for Identification of UBC13 Inhibitors

Tram A. Ngo, John Calvin Reed, K. Welsh, 2012, Journal of biomolecular screening.

Fragment-based design of small molecule X-linked inhibitor of apoptosis protein inhibitors.

Bainan Wu, Maurizio Pellecchia, Kate Welsh, 2008, Journal of medicinal chemistry.

A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC

R. Houghten, M. Ranson, C. Pinilla, 2009, British Journal of Cancer.

High-Throughput Fluorescence Assay for Small-Molecule Inhibitors of Autophagins/Atg4

John Calvin Reed, K. Welsh, E. Sergienko, 2011, Journal of biomolecular screening.

Table 1, PubChem Assay Summaries for Probe project

Darren Finlay, Robert Ardecky, Thomas D.Y. Chung, 2010 .

Salmonella secreted factor L deubiquitinase of Salmonella typhimurium inhibits NF-kappaB, suppresses IkappaBalpha ubiquitination and modulates innate immune responses.

A. Godzik, John Calvin Reed, M. Loeffler, 2008, Journal of immunology.

Small-Molecule XIAP Inhibitors Derepress Downstream Effector Caspases and Induce Apoptosis of Leukemia Cell Lines and Patient Samples.

M. Minden, John Calvin Reed, R. Houghten, 2004 .

ARTS and Siah collaborate in a pathway for XIAP degradation.

J. B. Garrison, John Calvin Reed, K. Welsh, 2011, Molecular cell.