H. Clewell

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Physiologically-Based Pharmacokinetic (PBPK) Modeling and Risk Assessment

M. Andersen, H. Clewell, R. Clewell, 2011 .

Molecular Signaling Network Motifs Provide a Mechanistic Basis for Cellular Threshold Responses

Melvin E. Andersen, Harvey J. Clewell, Sudin Bhattacharya, 2014, Environmental health perspectives.

Development of a physiologically based pharmacokinetic model of diisononyl phthalate (DiNP) in pregnant rat and human

Jerry L. Campbell, M. Longnecker, H. Clewell, 2020, Journal of toxicology and environmental health. Part A.

Evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry.

Harvey J Clewell, Ramesh Sarangapani, P Robinan Gentry, 2004, Toxicological sciences : an official journal of the Society of Toxicology.

Reverse dosimetry: interpreting trihalomethanes biomonitoring data using physiologically based pharmacokinetic modeling

Harvey J Clewell, Yu-Mei Tan, Kai H Liao, 2007, Journal of Exposure Science and Environmental Epidemiology.

Quantitative interpretation of human biomonitoring data.

Jerry L. Campbell, M. Andersen, H. Clewell, 2008, Toxicology and applied pharmacology.

Probabilistic Reverse Dosimetry Modeling for Interpreting Biomonitoring Data

H. Clewell, Y. Tan, 2010 .

In vitro metabolism of di(2-ethylhexyl) phthalate (DEHP) by various tissues and cytochrome P450s of human and rat.

Melvin E. Andersen, Harvey J. Clewell, Rebecca A. Clewell, 2012, Toxicology in vitro : an international journal published in association with BIBRA.

PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals.

M. Jamei, H. Clewell, F. Bois, 2010, Toxicology.

Genome-wide analysis of DNA methylation and gene expression changes in the mouse lung following subchronic arsenate exposure.

Lu Zhang, G. Schroth, Russell S. Thomas, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Application of transcriptional benchmark dose values in quantitative cancer and noncancer risk assessment.

Russell S. Thomas, M. Andersen, H. Clewell, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Risk Assessment Extrapolations and Physiological Modeling

M. Andersen, H. Clewell, 1985, Toxicology and industrial health.

Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.

F. A. Smith, M. Andersen, H. Clewell, 1987, Toxicology and applied pharmacology.

Evaluation of a predictive in vitro Leydig cell assay for anti-androgenicity of phthalate esters in the rat.

Jerry L. Campbell, H. Clewell, R. Clewell, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

RE: Response to the Office of Environmental Health Hazard Assessment on comments related to Gentry et al. (2021).

Chihae Yang, J. Rathman, H. Clewell, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Integration of Evidence to Evaluate the Potential for Neurobehavioral Effects Following Exposure to USFDA-Approved Food Colors.

Chihae Yang, J. Rathman, H. Clewell, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Determination of a site-specific reference dose for methylmercury for fish-eating populations.

H J Clewell, A M Shipp, H. Clewell, 2000, Toxicology and industrial health.

Physiologically Based Pharmacokinetic Modeling : Science and Applications

Melvin E. Andersen, Harvey J. Clewell, Raymond S. H. Yang, 2005 .

Bayesian Estimation of Pharmacokinetic and Pharmacodynamic Parameters in a Mode‐of‐Action‐Based Cancer Risk Assessment for Chloroform

Harvey J Clewell, Melvin E Andersen, Yu-Mei Tan, 2007, Risk analysis : an official publication of the Society for Risk Analysis.

Revised assessment of cancer risk to dichloromethane II. Application of probabilistic methods to cancer risk determinations.

Harvey J Clewell, Dale J Marino, P Robinan Gentry, 2006, Regulatory toxicology and pharmacology : RTP.

Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites.

Harvey J Clewell, Weihsueh A Chiu, H. Clewell, 2006, Regulatory toxicology and pharmacology : RTP.

Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays.

Harvey J Clewell, Melvin E Andersen, Richard S Judson, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

An Analysis of N-Acetylcysteine Treatment for Acetaminophen Overdose Using a Systems Model of Drug-Induced Liver Injury

Melvin E. Andersen, Harvey J. Clewell, Brett A. Howell, 2012, Journal of Pharmacology and Experimental Therapeutics.

High-throughput in-silico prediction of ionization equilibria for pharmacokinetic modeling.

Harvey J. Clewell, Kamel Mansouri, John F. Wambaugh, 2018, The Science of the total environment.

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI

Melvin E. Andersen, Harvey J. Clewell, Brett A. Howell, 2012, Journal of Pharmacokinetics and Pharmacodynamics.

Physiologically Based Pharmacokinetic Modeling

Melvin E. Andersen, Harvey J. Clewell, Thierry Lavé, 2010 .

Use of in vitro data in developing a physiologically based pharmacokinetic model: Carbaryl as a case study.

Miyoung Yoon, G. L. Kedderis, H. Clewell, 2015, Toxicology.

Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing

Melvin E. Andersen, Harvey J. Clewell, Barbara A. Wetmore, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Quantitative bias analysis of the association of type 2 diabetes mellitus with 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153).

M. Longnecker, H. Clewell, F. Wania, 2019, Environment international.

Incorporating population variability and susceptible subpopulations into dosimetry for high-throughput toxicity testing.

Harvey J. Clewell, Barbara A. Wetmore, John F. Wambaugh, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Development of a physiologically based pharmacokinetic model for volatile fractions of gasoline using chemical lumping analysis.

Raymond S. H. Yang, M. Andersen, H. Clewell, 2004, Environmental science & technology.

Analysis of Transcriptomic Dose–Response Data for Toxicology and Risk Assessment

Russell S. Thomas, M. Andersen, H. Clewell, 2011 .

Toxicant-inflicted injury and stimulated tissue repair are opposing toxicodynamic forces in predictive toxicology.

M. Soni, H. Clewell, H. Mehendale, 1999, Regulatory toxicology and pharmacology : RTP.

A physiologically based toxicokinetic model for the uptake and disposition of waterborne organic chemicals in fish.

M. Andersen, H. Clewell, R. Erickson, 1990, Toxicology and applied pharmacology.

Is the Relationship between Prenatal Exposure to PCB-153 and Decreased Birth Weight Attributable to Pharmacokinetics?

M. Longnecker, M. Andersen, H. Clewell, 2013, Environmental health perspectives.

Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment.

H. Clewell, R. Clewell, C. Thompson, 2019, Chemico-biological interactions.

Physiologically Based Pharmacokinetic Modeling: A Tool for Understanding ADMET Properties and Extrapolating to Human

M. Andersen, H. Clewell, T. Lavé, 2013 .

Evaluating Pharmacokinetic and Pharmacodynamic Interactions with Computational Models in Supporting Cumulative Risk Assessment

Jerry L. Campbell, M. Andersen, H. Clewell, 2011, International journal of environmental research and public health.

Modeling Kinetic Interactions of Chemical Mixtures

Jerry L. Campbell, M. Andersen, K. Krishnan, 2010 .

Using exposure prediction tools to link exposure and dosimetry for risk-based decisions: A case study with phthalates

Yu-Mei Tan, Miyoung Yoon, Marjory Moreau, 2017, Chemosphere.

Pharmacokinetic bias analysis of an association between clinical thyroid disease and two perfluoroalkyl substances.

Michael W. Dzierlenga, M. Longnecker, H. Clewell, 2020, Environment international.

Using a physiologically based pharmacokinetic model to link urinary biomarker concentrations to dietary exposure of perchlorate.

H. Clewell, B. Blount, Y. Tan, 2012, Chemosphere.

In vitro intestinal and hepatic metabolism of Di(2-ethylhexyl) phthalate (DEHP) in human and rat.

Jerry L. Campbell, M. Andersen, H. Clewell, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

PLETHEM – An interactive open-source platform for bridging the source-to-outcome continuum

H. Clewell, R. Clewell, P. McMullen, 2017 .

In Vitro – In Vivo Extrapolation

H. Clewell, M. Yoon, 2014 .

Current Approaches and Techniques in Physiologically Based Pharmacokinetic (PBPK) Modelling of Nanomaterials

H. Clewell, W. Utembe, M. Gulumian, 2020, Nanomaterials.

Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment

Jeffrey M. Minucci, Katherine A. Phillips, Brandall L. Ingle, 2021, Regulatory toxicology and pharmacology : RTP.

Considerations for Improving Metabolism Predictions for In Vitro to In Vivo Extrapolation

Chantel I. Nicolas, H. Clewell, R. Clewell, 2022, Frontiers in Toxicology.

Airborne Exposure to Arsenic Occurring in Coal Fly Ash

M. Hicks, H. Clewell, E. Fabianova, 1999 .

The application of PBPK models in estimating human brain tissue manganese concentrations

D. Krewski, M. Andersen, H. Clewell, 2017, Neurotoxicology.

Physiologically-based pharmacokinetic scaling in retinoid developmental toxicity

H. Clewell, C. Willhite, 2000 .

Physiologically‐based pharmacokinetic modeling suggests similar bioavailability of Mn from diet and drinking water

M. Andersen, H. Clewell, Michael D. Taylor, 2018, Toxicology and applied pharmacology.

Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part II: Physiologically Based Pharmacokinetic Modeling and Manganese Risk Assessment

M. Andersen, H. Clewell, D. Dorman, 2012, Journal of toxicology.

Physiologically based pharmacokinetic modeling of fetal and neonatal manganese exposure in humans: describing manganese homeostasis during development.

M. Andersen, H. Clewell, D. Dorman, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Analysis of manganese tracer kinetics and target tissue dosimetry in monkeys and humans with multi-route physiologically based pharmacokinetic models.

M. Andersen, H. Clewell, D. Dorman, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Pharmacokinetic Modeling of Manganese. I. Dose Dependencies of Uptake and Elimination

M. Andersen, H. Clewell, D. Dorman, 2007, Journal of toxicology and environmental health. Part A.

Application of a multi-route physiologically based pharmacokinetic model for manganese to evaluate dose-dependent neurological effects in monkeys.

M. Andersen, H. Clewell, D. Dorman, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Assessing children's exposure to manganese in drinking water using a PBPK model.

M. Andersen, H. Clewell, M. Suh, 2019, Toxicology and applied pharmacology.

Pharmacokinetic Modeling of Manganese in the Rat IV: Assessing Factors that Contribute to Brain Accumulation During Inhalation Exposure

M. Andersen, H. Clewell, D. Dorman, 2008, Journal of toxicology and environmental health. Part A.

Toxicokinetics and Pharmacokinetic Modeling of Arsenic

H. Clewell, E. Kenyon, 2015 .

Use of mode of action data to inform a dose-response assessment for bladder cancer following exposure to inorganic arsenic.

H. Clewell, R. Clewell, J. Yager, 2014, Toxicology in vitro : an international journal published in association with BIBRA.

Development of 3 D Dynamic Flow Model of Human Liver and Its Application to Prediction of Metabolic Clearance of 7-Ethoxycoumarin

Russell S. Thomas, M. Andersen, H. Clewell, 2014 .

Development of multi-route physiologically-based pharmacokinetic models for ethanol in the adult, pregnant, and neonatal rat

Jerry L. Campbell, William R Lefew, P. Bushnell, 2012, Inhalation toxicology.

Lactational transfer of manganese in rats: predicting manganese tissue concentration in the dam and pups from inhalation exposure with a pharmacokinetic model.

M. Andersen, H. Clewell, D. Dorman, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

A preliminary regional PBPK model of lung metabolism for improving species dependent descriptions of 1,3-butadiene and its metabolites.

Harvey Clewell, Jerry Campbell, Cynthia Van Landingham, 2015, Chemico-biological interactions.

PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING OF STYRENE AND STYRENE OXIDE RESPIRATORY-TRACT DOSIMETRY IN RODENTS AND HUMANS

M. Andersen, H. Clewell, R. Sarangapani, 2002, Inhalation toxicology.

EFSA's 21st Scientific Colloquium on Harmonisation of human and ecological risk assessment of combined exposure to multiple chemicals

S. H. Bennekou, Q. Chaudhry, J. Schlatter, 2015 .

Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver

Melvin E. Andersen, Harvey J. Clewell, Michael B. Black, 2017, Toxicology and Applied Pharmacology.

Gas uptake studies of deuterium isotope effects on dichloromethane metabolism in female B6C3F1 mice in vivo.

M. Andersen, H. Clewell, J. Gearhart, 1994, Toxicology and applied pharmacology.

COMPARING RESPIRATORY-TRACT AND HEPATIC EXPOSURE-DOSE RELATIONSHIPS FOR METABOLIZED INHALED VAPORS: A PHARMACOKINETIC ANALYSIS

M. Andersen, H. Clewell, R. Sarangapani, 2002, Inhalation toxicology.

Pharmacokinetic Modeling of Manganese. II. Hepatic Processing After Ingestion and Inhalation

M. Andersen, H. Clewell, D. Dorman, 2007, Journal of toxicology and environmental health. Part A.

Pharmacokinetic Modeling of Manganese. III. Physiological Approaches Accounting for Background and Tracer Kinetics

M. Andersen, H. Clewell, A. Nong, 2007, Journal of toxicology and environmental health. Part A.

Determination of an Occupational Exposure Guideline for Manganese Using the Benchmark Method

H. Clewell, D. Calne, K. Crump, 2003, Risk analysis : an official publication of the Society for Risk Analysis.

Preclinical Development Handbook: ADME and Biopharmaceutical Properties

Melvin E. Andersen, Harvey J. Clewell, Thierry Lavé, 2007 .

The impact of recent advances in research on arsenic cancer risk assessment.

H. Clewell, J. Yager, P. Gentry, 2014, Regulatory toxicology and pharmacology : RTP.

Application of the Risk Assessment Approaches in the USEPA Proposed Cancer Guidelines to Inorganic Arsenic

M. Andersen, H. Clewell, J. Yager, 1999 .

Effects of endogenous formaldehyde in nasal tissues on inhaled formaldehyde dosimetry predictions in the rat, monkey, and human nasal passages.

Jerry L. Campbell, M. Andersen, H. Clewell, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Physiologically based pharmacokinetic model for the inhibition of acetylcholinesterase by organophosphate esters.

G. W. Jepson, M. Andersen, H. Clewell, 1994, Environmental health perspectives.

Refinement of the oral exposure description in the cyclic siloxane PBPK model for rats and humans: Implications for exposure assessment.

Jerry L. Campbell, M. Andersen, H. Clewell, 2017, Toxicology letters.

The Conundrum of the PFOA human half-life, an international collaboration.

Jerry L. Campbell, H. Clewell, R. Prueitt, 2022, Regulatory toxicology and pharmacology : RTP.

An Objective Uncertainty Factor Adjustment for Methyl mercury Pharmacokinetic Variability

H. Clewell, A. Stern, J. Swartout, 2002 .

Physiologically Based Pharmacokinetic Modeling in Risk Assessment: Case Study With Pyrethroids

B. Lake, H. Clewell, R. Hines, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Weighing evidence and assessing uncertainties

M. Greiner, J. Dorne, G. Suter, 2016 .

Temporal concordance between apical and transcriptional points of departure for chemical risk assessment.

Melvin E. Andersen, Harvey J. Clewell, Michael B. Black, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Time‐ and concentration‐dependent genomic responses of the rat airway to inhaled nickel sulfate

H. Clewell, D. Dodd, A. Oller, 2017, Environmental and molecular mutagenesis.

Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: a five chemical case study.

Melvin E. Andersen, Harvey J. Clewell, Longlong Yang, 2012, Mutation research.

A method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure.

Harvey J Clewell, Melvin E Andersen, Bruce C Allen, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

Incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene

Jerry L. Campbell, M. Andersen, H. Clewell, 2019, Inhalation toxicology.

Response to “letter concerning: Clewell (2019) incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene.” (UIHT-2020-0053)

M. Andersen, H. Clewell, D. Dodd, 2020, Inhalation toxicology.

Comment on M.V. Evans and J.C. Caldwell: evaluation of two different metabolic hypotheses for dichloromethane toxicity using physiologically based pharmacokinetic modeling of in vivo gas uptake data exposure in female B6C3F1 mice, Toxicol. Appl. Pharmacol., 244, 280-290, 2010.

M. Andersen, H. Clewell, R. Reitz, 2010, Toxicology and applied pharmacology.

Quantitative Estimates of Risk for Noncancer Endpoints

H. Clewell, K. Crump, 2005, Risk analysis : an official publication of the Society for Risk Analysis.

The perils and promise of modern risk assessment: the example of trichloroethylene.

H. Clewell, J. Kester, 2004, Clinics in occupational and environmental medicine.

Paraquat pharmacokinetics in primates and extrapolation to humans.

Jerry L. Campbell, H. Clewell, D. Wolf, 2021, Toxicology and applied pharmacology.

Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment.

Robert J Kavlock, Harvey J Clewell, Melvin E Andersen, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Xenobiotic Metabolism in Alginate-Encapsulated Primary Human Hepatocytes Over Long Timeframes

M. Andersen, H. Clewell, J. Macdonald, 2018, Applied In Vitro Toxicology.

Deriving an explicit hepatic clearance equation accounting for plasma protein binding and hepatocellular uptake.

M. Andersen, H. Clewell, M. Yoon, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment - A case study with parabens.

M. Cronin, H. Clewell, E. Mombelli, 2022, Regulatory toxicology and pharmacology : RTP.

Quantitative in vitro to in vivo extrapolation of cell-based toxicity assay results

Harvey J Clewell, Melvin E Andersen, Miyoung Yoon, 2012, Critical reviews in toxicology.

An in vitro approach to determine the human relevance of anti-spermatogenic effects of 4-methylmorpholine 4-oxide, monohydrate (NMMO) in rat reproductive toxicity studies.

H. Clewell, R. Clewell, R. Gentry, 2022, Toxicology in vitro : an international journal published in association with BIBRA.

Evaluation of Age-Related Pyrethroid Pharmacokinetic Differences in Rats: Physiologically-Based Pharmacokinetic Model Development Using In Vitro Data and In Vitro to In Vivo Extrapolation.

B. Lake, H. Clewell, P. Hinderliter, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

A physiologically based pharmacokinetic model for inhaled carbon tetrachloride.

D J Paustenbach, H J Clewell, M E Andersen, 1988, Toxicology and applied pharmacology.

Multi-Dose-Route, Multi-Species Pharmacokinetic Models for Manganese and Their Use in Risk Assessment

Harvey J Clewell, Melvin E Andersen, Andy Nong, 2010, Journal of toxicology and environmental health. Part A.

Updating physiologically based pharmacokinetic models for manganese by incorporating rapid association/dissociation processes in tissues

M. Andersen, H. Clewell, P. Gentry, 2019, Toxicology and applied pharmacology.

Pharmacokinetic bias analysis of the epidemiological associations between serum polybrominated diphenyl ether (BDE-47) and timing of menarche.

M. Longnecker, M. Andersen, H. Clewell, 2016, Environmental research.

Can the observed association between serum perfluoroalkyl substances and delayed menarche be explained on the basis of puberty-related changes in physiology and pharmacokinetics?

M. Longnecker, J. Xue, M. Andersen, 2015, Environment international.

Physiologically based pharmacokinetic modeling of the lactating rat and nursing pup: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid.

D. H. Taylor, M. Andersen, H. Clewell, 1990, Toxicology and applied pharmacology.

Application of the adverse outcome pathway (AOP) approach to inform mode of action (MOA): A case study with inorganic arsenic

H. Clewell, J. Yager, P. Gentry, 2018, Journal of toxicology and environmental health. Part A.

Quantitative bias analysis of a reported association between perfluoroalkyl substances (PFAS) and endometriosis: The influence of oral contraceptive use.

Christopher D. Ruark, M. Longnecker, M. Andersen, 2017, Environment international.

Kinetics of metabolism of deltamethrin and cis- and trans-permethrin in vitro. Studies using rat and human liver microsomes, isolated rat hepatocytes and rat liver cytosol

J. Houston, R. J. Price, B. Lake, 2020, Xenobiotica; the fate of foreign compounds in biological systems.

Excretion of Di-2-ethylhexyl phthalate (DEHP) metabolites in urine is related to body mass index because of higher energy intake in the overweight and obese.

Jerry L. Campbell, M. Longnecker, H. Clewell, 2018, Environment international.

Assessing Bioactivity-Exposure Profiles of Fruits and Vegetables in the BioMAP Profiling System

Michael B. Black, Bethany B. Parks, E. Berg, 2019 .

Prenatal PCB-153 Exposure and Decreased Birth Weight: Verner et al. Respond

M. Longnecker, M. Andersen, H. Clewell, 2014, Environmental health perspectives.

The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene.

Jerry L. Campbell, I. Rusyn, A. Knap, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Integration of paraquat pharmacokinetic data across species using PBPK modelling.

Jerry L. Campbell, M. Andersen, H. Clewell, 2021, Toxicology and applied pharmacology.

Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages

B. Lake, H. Clewell, Xueying Sun, 2017, Drug Metabolism and Disposition.

Data for Physiologically Based Pharmacokinetic Modeling in Neonatal Animals: Physiological Parameters in Mice and Sprague-Dawley Rats

Hugh A. Barton, Harvey J. Clewell, Tammie R. Covington, 2004 .

Chemical Risk Analysis: A Practical Handbook

Harvey J. Clewell, H. Clewell, 2002 .

Requirements for a Biologically Realistic Cancer Risk Assessment for Inorganic Arsenic

M. Andersen, H. Clewell, J. Yager, 1999 .

Acrylamide: Review of Toxicity Data and Dose-Response Analyses for Cancer and Noncancer Effects

H. Clewell, H. Clewell, B. Allen, 2006, Critical reviews in toxicology.

Dose-response for assessing the cancer risk of inorganic arsenic in drinking water: the scientific basis for use of a threshold approach

P. Boffetta, E. Chang, H. Clewell, 2019, Critical reviews in toxicology.

Trichloroacetate Tissue Dosimetry and PPAR alpha-Mediated Liver Cancer Induction by Trichioroethylene and Perchioroethylene

H. Clewell, P. Gentry, H. Barton, 2000 .

Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: the first steps.

George Loizou, Harvey J Clewell, Hugh A Barton, 2008, Regulatory toxicology and pharmacology : RTP.

Development and specification of physiologically based pharmacokinetic models for use in risk assessment.

Harvey J Clewell, Rebecca A Clewell, H. Clewell, 2008, Regulatory toxicology and pharmacology : RTP.

Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in C57BL6 mice following subchronic exposure to arsenate in drinking water.

H. Clewell, J. Yager, E. Kenyon, 2008, Toxicology and applied pharmacology.

Evaluation of gene expression changes in human primary uroepithelial cells following 24‐Hr exposures to inorganic arsenic and its methylated metabolites

Russell S. Thomas, H. Clewell, L. Pluta, 2013, Environmental and molecular mutagenesis.

How can biologically-based modeling of arsenic kinetics and dynamics inform the risk assessment process? - A workshop review.

Harvey J Clewell, Barbara D Beck, Elaina M Kenyon, 2008, Toxicology and applied pharmacology.

Why is elevation of serum cholesterol associated with exposure to perfluoroalkyl substances (PFAS) in humans? A workshop report on potential mechanisms

M. Longnecker, J. Corton, G. Vega, 2021, Toxicology.

Kinetics of Water Vapor Sorption in Stratum Corneum

Harvey J. Clewell, James N. McDougal, Z. Liron, 1994 .

Kinetics of water vapor sorption in porcine stratum corneum.

H J Clewell, J N McDougal, Z. Liron, 1994, Journal of pharmaceutical sciences.

PBPK-Based Probabilistic Risk Assessment for Total Chlorotriazines in Drinking Water

Jerry L. Campbell, M. Andersen, H. Clewell, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Considering pharmacokinetic and mechanistic information in cancer risk assessments for environmental contaminants: examples with vinyl chloride and trichloroethylene.

H J Clewell, M E Andersen, B C Allen, 1995, Chemosphere.

Genetic polymorphisms in assessing interindividual variability in delivered dose.

M L Dourson, H J Clewell, H. Clewell, 2002, Regulatory toxicology and pharmacology : RTP.

New Framework for a Non-Animal Approach Adequately Assures the Safety of Cosmetic Ingredients - A Case Study on Caffeine.

M. Cronin, H. Clewell, N. Hewitt, 2021, Regulatory toxicology and pharmacology : RTP.

Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of action.

Harvey J Clewell, Kannan Krishnan, Kenneth T Bogen, 2008, Regulatory toxicology and pharmacology : RTP.

A physiological pharmacokinetic model for dermal absorption of vapors in the rat.

H J Clewell, M E Andersen, J N McDougal, 1986, Toxicology and applied pharmacology.

A physiologically based pharmacokinetic model for retinoic acid and its metabolites.

H J Clewell, M E Andersen, M. Andersen, 1997, Journal of the American Academy of Dermatology.

Review and Evaluation of the Potential Impact of Age- and Gender-Specific Pharmacokinetic Differences on Tissue Dosimetry

Harvey J. Clewell, Greg Lawrence, Justin Teeguarden, 2002, Critical reviews in toxicology.

Ground contamination by fuel jettisoned from aircraft in flight

H. J. Clewell, H. Clewell, 1983 .

Pharmacokinetic data needs to support risk assessments for inhaled and ingested manganese.

M. Andersen, H. Clewell, J. Gearhart, 1999, Neurotoxicology.

On the incorporation of biokinetic and mechanistic data in modeling for risk assessment

H. J. Clewell, H. Clewell, 2007 .

Derivation of a human equivalent concentration for n-butanol using a physiologically based pharmacokinetic model for n-butyl acetate and metabolites n-butanol and n-butyric acid.

H J Clewell, H A Barton, R A Corley, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI

P. Watkins, M. Andersen, Rukmini Kumar, 2012, Journal of Pharmacokinetics and Pharmacodynamics.

Evaluation of simple in vitro to in vivo extrapolation approaches for environmental compounds.

Bas J Blaauboer, Harvey J Clewell, Miyoung Yoon, 2014, Toxicology in vitro : an international journal published in association with BIBRA.

Application of pharmacokinetic data to the risk assessment of inhaled manganese.

Harvey J Clewell, Melvin E Andersen, David C Dorman, 2006, Neurotoxicology.

Development of Pbpk Models for Pfoa and Pfos for Human Pregnancy and Lactation Life Stages

Harvey J Clewell, Melvin E Andersen, Matthew P Longnecker, 2013, Journal of toxicology and environmental health. Part A.

Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK)

Melvin E. Andersen, Harvey J. Clewell, Miyoung Yoon, 2015, Environmental health perspectives.

Interspecies Dose Extrapolation for Inhaled Dimethyl Sulfate: A PBPK Model-Based Analysis using Nasal Cavity N7-Methylguanine Adducts

Harvey J Clewell, Hugh A Barton, Ramesh Sarangapani, 2004, Inhalation toxicology.

Physiologically based pharmacokinetic/toxicokinetic modeling.

Harvey J Clewell, Melvin E Andersen, Rebecca A Clewell, 2012, Methods in molecular biology.

Derivation of inhalation toxicity reference values for propylene oxide using mode of action analysis: Example of a threshold carcinogen

H. Clewell, C. Kirman, R. Albertini, 2009, Critical reviews in toxicology.

Evaluation and prediction of pharmacokinetics of PFOA and PFOS in the monkey and human using a PBPK model.

Harvey J Clewell, Melvin E Andersen, Anne E. Loccisano, 2011, Regulatory toxicology and pharmacology : RTP.

Relative contributions of endogenous and exogenous formaldehyde to formation of deoxyguanosine monoadducts and DNA-protein crosslink adducts of DNA in rat nasal mucosa

Jerry L. Campbell, H. Clewell, R. Conolly, 2022, Toxicological sciences : an official journal of the Society of Toxicology.

Population Life-course exposure to health effects model (PLETHEM): An R package for PBPK modeling

Harvey J. Clewell, Patrick D. McMullen, Miyoung Yoon, 2020 .

Improving Risk Assessment: Research Opportunities in Dose Response Modeling to Improve Risk Assessment

David B. Dunson, Harvey J. Clewell, A. John Bailer, 2002 .

Dermal absorption of organic chemical vapors in rats and humans.

H J Clewell, M E Andersen, M L Gargas, 1990, Fundamental and applied toxicology : official journal of the Society of Toxicology.

An updated mode of action and human relevance framework evaluation for Formaldehyde-Related nasal tumors

H. Clewell, C. Thompson, Kun Lu, 2020, Critical reviews in toxicology.

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing.

T. Knudsen, J. Jaworska, G. Patlewicz, 2012, ALTEX.

Consensus report on the future of animal-free systemic toxicity testing.

Mardas Daneshian, Thomas B Knudsen, Francois Busquet, 2014, ALTEX.

Analysis of genomic dose‐response information on arsenic to inform key events in a mode of action for carcinogenicity

H. Clewell, J. Yager, P. Gentry, 2009, Environmental and molecular mutagenesis.

Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropyfluorophosphate

Melvin E. Andersen, Harvey J. Clewell, Jeffery M. Gearhart, 1990 .

Developing context appropriate toxicity testing approaches using new alternative methods (NAMs).

Harvey J Clewell, Melvin E Andersen, Patrick D McMullen, 2019, ALTEX.

Evaluation of oral and intravenous route pharmacokinetics, plasma protein binding, and uterine tissue dose metrics of bisphenol A: a physiologically based pharmacokinetic approach.

Harvey J Clewell, Hugh A Barton, Justin G Teeguarden, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

Risk assessment of chemical mixtures: biologic and toxicologic issues.

H J Clewell, M M Mumtaz, H. Clewell, 1993, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Implementation of EPA Revised Cancer Assessment Guidelines: Incorporation of Mechanistic and Pharmacokinetic Data.

H J Clewell, M E Andersen, C B Frederick, 1997, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Application of Physiological Computational Fluid Dynamics Models to Predict Interspecies Nasal Dosimetry of Inhaled Acrolein

Harvey J. Clewell, David C. Dorman, Jeffry D. Schroeter, 2008 .

The use of non-tumor data in cancer risk assessment: reflections on butadiene, vinyl chloride, and benzene.

Stephen Olin, Raymond Tice, Harvey Clewell, 2003, Regulatory toxicology and pharmacology : RTP.

Derivation of an Inhalation Reference Concentration Based upon Olfactory Neuronal Loss in Male Rats following Subchronic Acetaldehyde Inhalation

Jerry L. Campbell, M. Andersen, H. Clewell, 2008 .

Application of physiological computational fluid dynamics models to predict interspecies nasal dosimetry of inhaled acrolein.

H. Clewell, D. Dorman, Y. Tan, 2008, Inhalation toxicology.

Application of a physiologically based pharmacokinetic model for isopropanol in the derivation of a reference dose and reference concentration.

Harvey J Clewell, Melvin E Andersen, M. Andersen, 2002, Regulatory toxicology and pharmacology : RTP.

Evaluating noncancer effects of trichloroethylene: dosimetry, mode of action, and risk assessment.

H J Clewell, H A Barton, H. Clewell, 2000, Environmental health perspectives.

Differential lymphatic versus portal vein uptake of the synthetic pyrethroids deltamethrin and cis-permethrin in rats.

B. Lake, H. Clewell, M. Yoon, 2020, Toxicology.

Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans

Harvey J Clewell, Miyoung Yoon, Salil N Pendse, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Addressing Early Life Sensitivity Using Physiologically Based Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation

Harvey J. Clewell, Miyoung Yoon, H. Clewell, 2016, Toxicological research.

Revised assessment of cancer risk to dichloromethane: part I Bayesian PBPK and dose-response modeling in mice.

Harvey J Clewell, Dale J Marino, P Robinan Gentry, 2006, Regulatory toxicology and pharmacology : RTP.

Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans.

H J Clewell, M E Andersen, M L Gargas, 1991, Toxicology and applied pharmacology.

Bayesian Calibration of a Physiologically Based Pharmacokinetic/Pharmacodynamic Model of Carbaryl Cholinesterase Inhibition

Harvey J. Clewell, Yu-Mei Tan, Andy Nong, 2008, Journal of toxicology and environmental health. Part A.

Evaluation of the Uncertainty in an Oral Reference Dose for Methylmercury Due to Interindividual Variability in Pharmacokinetics

Harvey J. Clewell, Jeffery M. Gearhart, Tammie R. Covington, 1999, Risk analysis : an official publication of the Society for Risk Analysis.

An approach for the quantitative consideration of genetic polymorphism data in chemical risk assessment: examples with warfarin and parathion.

Harvey J Clewell, Andrew Maier, P Robinan Gentry, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

A model of functional thyroid disease status over the lifetime

M. Longnecker, H. Clewell, B. Allen, 2019, PloS one.

Applying Mode-of-Action and Pharmacokinetic Considerations in Contemporary Cancer Risk Assessments: An Example with Trichloroethylene

Melvin E. Andersen, Harvey J. Clewell, M. Andersen, 2004 .

Allometric scaling of pegylated liposomal anticancer drugs

J. Schellens, J. Beijnen, H. Clewell, 2011, Journal of Pharmacokinetics and Pharmacodynamics.

Cancer and non‐cancer risk assessment should be harmonized

M. Andersen, H. Clewell, K. Crump, 1997 .

Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods.

H J Clewell, M E Andersen, M L Gargas, 1987, Toxicology and applied pharmacology.

Metabolism of inhaled dihalomethanes in vivo: differentiation of kinetic constants for two independent pathways.

H J Clewell, M E Andersen, M L Gargas, 1986, Toxicology and applied pharmacology.

Computer Simulation of Chemical Carcinogenesis

M. Andersen, H. Clewell, R. Conolly, 1989 .

Extended Analysis and Evidence Integration of Chloroprene as a Human Carcinogen

Sonja N. Sax, H. Clewell, P. Gentry, 2019, Risk analysis : an official publication of the Society for Risk Analysis.

Hormesis and Adaptive Cellular Control Systems

Harvey J Clewell, Melvin E Andersen, Annie M Jarabek, 2008, Dose-response : a publication of International Hormesis Society.

Exposure assessment and risk characterization for perfluorooctanoate in selected consumer articles.

Harvey J Clewell, Annette M Shipp, Robert C Buck, 2005, Environmental science & technology.

A consistent approach for the application of pharmacokinetic modeling in cancer and noncancer risk assessment.

Harvey J Clewell, Melvin E Andersen, Hugh A Barton, 2001, Environmental health perspectives.

A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair

Harvey J. Clewell, Miyoung Yoon, Kim L. R. Brouwer, 2012, Drug Metabolism and Disposition.

A physiologically based simulation approach for determining metabolic constants from gas uptake data.

H J Clewell, M E Andersen, M L Gargas, 1986, Toxicology and applied pharmacology.

Determination of a site-specific reference dose for methylmercury for fish-eating populations

Harvey J. Clewell, Greg Lawrence, Cynthia Van Landingham, 2000 .

A tissue dose‐based comparative exposure assessment of manganese using physiologically based pharmacokinetic modeling—The importance of homeostatic control for an essential metal

M. Andersen, H. Clewell, H. Roels, 2017, Toxicology and applied pharmacology.

Quantitative bias analysis for epidemiological associations of perfluoroalkyl substance serum concentrations and early onset of menopause.

Christopher D. Ruark, M. Longnecker, M. Andersen, 2017, Environment international.

PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop.

Harvey J Clewell, Kannan Krishnan, Ursula Gundert-Remy, 2014, Regulatory toxicology and pharmacology : RTP.

Using quantitative modeling tools to assess pharmacokinetic bias in epidemiological studies showing associations between biomarkers and health outcomes at low exposures.

M. Longnecker, M. Andersen, H. Clewell, 2021, Environmental research.

Time dependencies in perfluorooctylacids disposition in rat and monkeys: a kinetic analysis.

Harvey J Clewell, Melvin E Andersen, Yu-Mei Tan, 2008, Toxicology letters.

Evaluating placental transfer and tissue concentrations of manganese in the pregnant rat and fetuses after inhalation exposures with a PBPK model.

Harvey J Clewell, Melvin E Andersen, Miyoung Yoon, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Pharmacokinetic modeling of saturable, renal resorption of perfluoroalkylacids in monkeys--probing the determinants of long plasma half-lives.

Harvey J Clewell, Melvin E Andersen, Yu-Mei Tan, 2006, Toxicology.

Research toward the development of a biologically based dose response assessment for inorganic arsenic carcinogenicity: a progress report.

Harvey J Clewell, Janice W Yager, Elaina M Kenyon, 2007, Toxicology and applied pharmacology.

Modeling the effect of succimer (DMSA; dimercaptosuccinic acid) chelation therapy in patients poisoned by lead

J. Meulenbelt, H. Clewell, J. A. Vale, 2017, Clinical toxicology.

Comparison of cancer risk estimates for vinyl chloride using animal and human data with a PBPK model.

H J Clewell, M E Andersen, B C Allen, 2001, The Science of the total environment.

Use of Markov Chain Monte Carlo Analysis with a Physiologically‐Based Pharmacokinetic Model of Methylmercury to Estimate Exposures in U.S. Women of Childbearing Age

Harvey J Clewell, Bruce C Allen, C Eric Hack, 2007, Risk analysis : an official publication of the Society for Risk Analysis.

Challenges in the application of quantitative approaches in risk assessment: a case study with di-(2-ethylhexyl)phthalate

Harvey J Clewell, Jerry Campbell, P Robinan Gentry, 2011, Critical reviews in toxicology.

Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment.

H J Clewell, H. Clewell, T. Covington, 2000, Environmental health perspectives.

Reanalysis of dose-response data from the Iraqi methylmercury poisoning episode.

H. Clewell, J. Gearhart, K. Crump, 1995, Risk analysis : an official publication of the Society for Risk Analysis.

An evaluation of the USEPA Proposed Approaches for applying a biologically based dose‐response model in a risk assessment for perchlorate in drinking water

H. Clewell, R. Clewell, R. Gentry, 2019, Regulatory toxicology and pharmacology : RTP.

Use of physiologically based pharmacokinetic modeling to investigate individual versus population risk.

H J Clewell, M E Andersen, M. Andersen, 1996, Toxicology.

Physiologically based pharmacokinetic analyses of simple mixtures.

M. Andersen, K. Krishnan, H. Clewell, 1994, Environmental health perspectives.

Physiologically based pharmacokinetic modeling of the pregnant rat: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid.

H J Clewell, M E Andersen, D. H. Taylor, 1989, Toxicology and applied pharmacology.

Dermal absorption of dihalomethane vapors.

H J Clewell, M E Andersen, J N McDougal, 1985, Toxicology and applied pharmacology.

Evaluation of placental and lactational pharmacokinetics of PFOA and PFOS in the pregnant, lactating, fetal and neonatal rat using a physiologically based pharmacokinetic model.

Harvey J Clewell, Melvin E Andersen, Anne E. Loccisano, 2012, Reproductive toxicology.

Use ofin VitroData in PBPK Models: An Example ofin Vitrotoin VivoExtrapolation with Carbaryl

G. L. Kedderis, H. Clewell, B. Allen, 2012 .

Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates.

Harvey J Clewell, Melvin E Andersen, Yu-Mei Tan, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

Melvin E. Andersen, Harvey J. Clewell, Russell S. Thomas, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Considerations for refining the risk assessment process for formaldehyde: Results from an interdisciplinary workshop.

M. Andersen, H. Clewell, D. Coggon, 2019, Regulatory toxicology and pharmacology : RTP.

Evaluation of the potential impact of pharmacokinetic differences on tissue dosimetry in offspring during pregnancy and lactation.

Harvey J Clewell, P Robinan Gentry, H. Clewell, 2003, Regulatory toxicology and pharmacology : RTP.

Genomic signatures and dose-dependent transitions in nasal epithelial responses to inhaled formaldehyde in the rat.

Harvey J Clewell, Melvin E Andersen, Russell S. Thomas, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Predicting lung dosimetry of inhaled particleborne benzo[a]pyrene using physiologically based pharmacokinetic modeling

Harvey Clewell, Jerry Campbell, Cynthia Van Landingham, 2016, Inhalation toxicology.

Development of a rat and human PBPK model for bromate and estimation of human equivalent concentrations in drinking water

Jerry L. Campbell, H. Clewell, R. Bull, 2019, International journal of environmental health research.

An Alternative Exact Solution of the Two‐Stage Clonal Growth Model of Cancer

R. Hoogenveen, H. Clewell, W. Slob, 1999 .

An improved approximation to the exact solution of the two-stage clonal growth model of cancer.

M. Andersen, H. Clewell, R. Conolly, 1995, Risk analysis : an official publication of the Society for Risk Analysis.

On the incorporation of chemical-specific information in risk assessment.

Bas J Blaauboer, Harvey J Clewell, Melvin E Andersen, 2008, Toxicology letters.

A Pharmacokinetic Model of the Intracellular Dosimetry of Inhaled Nickel

H. Clewell, J. Yager, T. Covington, 2007, Journal of toxicology and environmental health. Part A.

Time- and concentration-dependent genomic responses of the rat airway to inhaled nickel subsulfide.

H. Clewell, D. Dodd, A. Oller, 2014, Toxicology and applied pharmacology.

Considerations for a Biologically Based Risk Assessment for Arsenic

H. Clewell, J. Yager, P. Gentry, 2015 .

Fluid Dynamic Modeling to Support the Development of Flow-Based Hepatocyte Culture Systems for Metabolism Studies

M. Andersen, H. Clewell, J. Macdonald, 2016, Front. Bioeng. Biotechnol..

Use of mode of action in risk assessment: past, present, and future.

Harvey Clewell, H. Clewell, 2005, Regulatory toxicology and pharmacology : RTP.

The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans.

Bas J Blaauboer, Harvey J Clewell, Mardas Daneshian, 2012, ALTEX.

p53 codon 271 CGT to CAT mutant fraction does not increase in nasal respiratory and olfactory epithelia of rats exposed to inhaled naphthalene.

H. Clewell, D. Dodd, B. Wong, 2011, Mutation research.

Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop

Andrew Worth, Bertrand Desprez, Martina Klaric, 2019, Regulatory toxicology and pharmacology : RTP.

PBPK Model for Atrazine and Its Chlorotriazine Metabolites in Rat and Human

Melvin E. Andersen, Harvey J. Clewell, Timothy P. Pastoor, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Kinetic characterization of CYP2E1 inhibition in vivo and in vitro by the chloroethylenes

M. Andersen, H. Clewell, M. Gargas, 1998, Archives of Toxicology.

Gas Uptake Inhalation Techniques and the Rates of Metabolism of Chloromethanes, Chloroethanes, and Chloroethylenes in the Rat

Melvin E. Andersen, Harvey J. Clewell, M. Andersen, 1990 .

Evidence of a "clear and consistent threshold" for bladder and liver cancer in the large ED01 carcinogenicity study.

H. Clewell, K. Crump, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Mode of Action Studies for Assessing Carcinogenic Risks Posed by Inorganic Arsenic

M. Andersen, H. Clewell, J. Yager, 1999 .

A case study on quantitative in vitro to in vivo extrapolation for environmental esters: Methyl-, propyl- and butylparaben.

Jerry L. Campbell, H. Clewell, M. Yoon, 2015, Toxicology.

Adjusting exposure limits for long and short exposure periods using a physiological pharmacokinetic model.

D J Paustenbach, H J Clewell, M E Andersen, 1987, American Industrial Hygiene Association journal.

Physiologically based pharmacokinetic model use in risk assessment--Why being published is not enough.

Harvey J Clewell, Hisham A El-Masri, John F Wambaugh, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.

Robert J Kavlock, Harvey J Clewell, Melvin E Andersen, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Development of a Screening Approach to Interpret Human Biomonitoring Data on Volatile Organic Compounds: Reverse Dosimetry on Biomonitoring Data for Trichloroethylene

Harvey J Clewell, Yu-Mei Tan, Kai H Liao, 2007, Risk analysis : an official publication of the Society for Risk Analysis.

Development of a physiologically based pharmacokinetic model of isopropanol and its metabolite acetone.

H J Clewell, M E Andersen, M. Andersen, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

Application of a hybrid CFD-PBPK nasal dosimetry model in an inhalation risk assessment: an example with acrylic acid.

C B Frederick, M. Andersen, H. Clewell, 2000, Toxicological sciences : an official journal of the Society of Toxicology.

Quantitative bias analysis of the association between subclinical thyroid disease and two perfluoroalkyl substances in a single study.

Michael W. Dzierlenga, Jerry L. Campbell, M. Longnecker, 2019, Environmental research.

Perchlorate and Radioiodide Kinetics Across Life Stages in the Human: Using PBPK Models to Predict Dosimetry and Thyroid Inhibition and Sensitive Subpopulations Based on Developmental Stage

Harvey J Clewell, Rebecca A Clewell, David R Mattie, 2007, Journal of toxicology and environmental health. Part A.

Updating the biologically based dose-response model for the nasal carcinogenicity of inhaled formaldehyde in the F344 rat

M. Andersen, H. Clewell, R. Conolly, 2023, Toxicological sciences : an official journal of the Society of Toxicology.

Incorporation of a Recirculating Mobile Lipid Pool Description into the Cyclic Volatile Siloxane (cVMS) PBPK Model Captures Terminal Clearance of D4 after Repeated inhalation Exposure in F344 and SD Rats.

Jerry L. Campbell, H. Clewell, R. Gentry, 2022, Toxicology letters.

Physiologically Based Pharmacokinetic (PBPK) Modeling of Interstrain Variability in Trichloroethylene Metabolism in the Mouse

Harvey J. Clewell, Fred A. Wright, Weihsueh A. Chiu, 2014, Environmental health perspectives.

Quantitative in vitro to in vivo extrapolation (QIVIVE): An essential element for in vitro-based risk assessment.

Bas J Blaauboer, Harvey J Clewell, Miyoung Yoon, 2015, Toxicology.

Concentration- and time-dependent genomic changes in the mouse urinary bladder following exposure to arsenate in drinking water for up to 12 weeks.

R. S. Thomas, H. Clewell, J. Yager, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Making sense of human biomonitoring data: Findings and recommendations of a workshop

Harvey J Clewell, Chris D Money, Richard D Phillips, 2007, Journal of Exposure Science and Environmental Epidemiology.

Incorporation of rapid association/dissociation processes in tissues into the monkey and human physiologically based pharmacokinetic models for manganese

Jerry L. Campbell, M. Andersen, H. Clewell, 2022, Toxicological sciences : an official journal of the Society of Toxicology.

Can case study approaches speed implementation of the NRC report: "toxicity testing in the 21st century: a vision and a strategy?".

Harvey J Clewell, Melvin E Andersen, Kim Boekelheide, 2011, ALTEX.

Evaluation of gene expression changes in human primary lung epithelial cells following 24‐hr exposures to inorganic arsenic and its methylated metabolites and to arsenic trioxide

H. Clewell, J. Seagrave, J. Yager, 2015, Environmental and molecular mutagenesis.

Use of a Physiologically Based Pharmacokinetic Model to Identify Exposures Consistent With Human Biomonitoring Data for Chloroform

Harvey J Clewell, Yu-Mei Tan, Kai H Liao, 2006, Journal of toxicology and environmental health. Part A.

An integrated health risk assessment of contaminated sites under aleatory and epistemic uncertainties

Harvey J. Clewell, Hua Li, Gopal Achari, 2011 .

Evaluation of Physiologically Based Pharmacokinetic Models in Risk Assessment: An Example with Perchloroethylene

Harvey J Clewell, Melvin E Andersen, P Robinan Gentry, 2005, Critical reviews in toxicology.

The application of physiologically based pharmacokinetic modeling in human health risk assessment of hazardous substances.

H J Clewell, H. Clewell, 1995, Toxicology letters.

Biologically motivated models for chemical risk assessment.

H J Clewell, M E Andersen, M. Andersen, 1989, Health physics.

Physiologically based pharmacokinetic modeling software

Andreas Schepky, Harvey J. Clewell, C. E. Hack, 2020 .

Evaluating opportunities for advancing the use of alternative methods in risk assessment through the development of fit-for-purpose in vitro assays.

Harvey J Clewell, Melvin E Andersen, Martin B Phillips, 2018, Toxicology in vitro : an international journal published in association with BIBRA.

The use of Markov chain Monte Carlo uncertainty analysis to support a Public Health Goal for perchloroethylene.

Harvey J Clewell, Melvin E Andersen, M. Andersen, 2007, Regulatory toxicology and pharmacology : RTP.

Application of a Physiologically Based Pharmacokinetic Model for Reference Dose and Reference Concentration Estimation for Acetone

Harvey Clewell, H. Clewell, P. Gentry, 2003, Journal of toxicology and environmental health. Part A.

Harmonization: Developing Consistent Guidelines for Applying Mode of Action and Dosimetry Information to Cancer and Noncancer Risk Assessment

Hugh A. Barton, Melvin E. Andersen, Harvey J. Clewell, 1998 .

Bayesian Analysis of A Rat Formaldehyde DNA–Protein Cross-Link Model

Harvey J Clewell, Yu-Mei Tan, Bruce C Allen, 2010, Journal of toxicology and environmental health. Part A.

Pharmacokinetic dose estimates of mercury in children and dose-response curves of performance tests in a large epidemiological study

H. J. Clewell, Abraham Silvers, K. S. Crump, 1995 .

Investigation of the potential impact of benchmark dose and pharmacokinetic modeling in noncancer risk assessment.

H J Clewell, H. Clewell, J. Gearhart, 1997, Journal of toxicology and environmental health.

Investigation of the impact of pharmacokinetic variability and uncertainty on risks predicted with a pharmacokinetic model for chloroform.

H J Clewell, B C Allen, H. Clewell, 1996, Toxicology.

Sensitivity of physiologically based pharmacokinetic models to variation in model parameters: methylene chloride.

H J Clewell, R L Carpenter, H. Clewell, 1994, Risk analysis : an official publication of the Society for Risk Analysis.

Letter to the editor re: Cheng, YH., Chou, WC., Yang, YF. et al. Environ Sci Pollut Res (2017). https://doi.org/10.1007/s11356-017-0875-4

Jerry L. Campbell, H. Clewell, P. Hinderliter, 2018, Environmental Science and Pollution Research.

Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound.

Jerry L. Campbell, Russell S. Thomas, M. Andersen, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehyde.

M. Andersen, H. Clewell, E. Bermudez, 2010, Regulatory toxicology and pharmacology : RTP.

Recent Applications Of Physiologically Based Pharmacokinetic Modeling To Assess The Toxicity Of Mixtures: A Review

Jerry L. Campbell, H. Clewell, M. Linakis, 2023, Current Opinion in Toxicology.

Response to Comments by Caldwell et al. on Article “Applying Mode-of-Action and Pharmacokinetic Considerations in Contemporary Cancer Risk Assessments: An Example with Trichloroethylene”

M. Andersen, H. Clewell, 2006, Critical reviews in toxicology.

Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system.

Harvey J Clewell, Melvin E Andersen, Salil N Pendse, 2019, Toxicology in vitro : an international journal published in association with BIBRA.

Manganese tissue dosimetry in rats and monkeys: accounting for dietary and inhaled Mn with physiologically based pharmacokinetic modeling.

M. Andersen, H. Clewell, D. Dorman, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Cross-species transcriptomic analysis of mouse and rat lung exposed to chloroprene.

Melvin E. Andersen, Harvey J. Clewell, Michael B. Black, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Kinetic modeling of β-chloroprene metabolism: Probabilistic in vitro-in vivo extrapolation of metabolism in the lung, liver and kidneys of mice, rats and humans.

Harvey J Clewell, H. Clewell, Yuching Yang, 2012, Toxicology in vitro : an international journal published in association with BIBRA.

Applying simulation modeling to problems in toxicology and risk assessment--a short perspective.

H J Clewell, M E Andersen, C B Frederick, 1995, Toxicology and applied pharmacology.

Derivation of an inhalation reference concentration based upon olfactory neuronal loss in male rats following subchronic acetaldehyde inhalation.

Jerry L. Campbell, M. Andersen, H. Clewell, 2008, Inhalation toxicology.

Incorporation of Pharmacokinetic and Pharmacodynamic Data into Risk Assessments

Kannan Krishnan, John C Lipscomb, Harvey Clewell, 2004, Toxicology mechanisms and methods.

Transcriptional responses in the rat nasal epithelium following subchronic inhalation of naphthalene vapor.

R. S. Thomas, H. Clewell, D. Dodd, 2014, Toxicology and applied pharmacology.

Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effects on PBPK model predictions in a risk assessment for perchloroethylene (PCE).

H J Clewell, J W Fisher, H. Clewell, 1993, Toxicology letters.

Improving the Development and Use of Biologically Based Dose Response Models (BBDR) in Risk Assessment

Harvey J. Clewell, R. Woodrow Setzer, Robert S. DeWoskin, 2001 .

Evaluation of the Potential Impact of Age- and Gender-Specific Lung Morphology and Ventilation Rate on the Dosimetry of Vapors

Tammie R. Covington, Justin G. Teeguarden, Ramesh Sarangapani, 2003, Inhalation toxicology.

Introduction: A Historical Perspective of the Development and Applications of PBPK Models

Melvin E. Andersen, Harvey J. Clewell, Raymond S. H. Yang, 2005 .

Food for Thought ... Can Case Study Approaches Speed Implementation of the NRC Report : “ Toxicity Testing in the 21 st Century : A Vision and a Strategy ? ”

Melvin E. Andersen, Harvey J. Clewell, Paul L. Carmichael, 2011 .

Comparison and evaluation of pharmacokinetics of PFOA and PFOS in the adult rat using a physiologically based pharmacokinetic model.

Anne E. Loccisano, M. Andersen, H. Clewell, 2012, Reproductive toxicology.

Using available in vitro metabolite identification and time course kinetics for β-chloroprene and its metabolite, (1-chloroethenyl) oxirane, to include reactive oxidative metabolites and glutathione depletion in a PBPK model for β-chloroprene

M. Andersen, H. Clewell, P. Gentry, 2023, Frontiers in pharmacology.

Development of an integrated multi-species and multi-dose route PBPK model for volatile methyl siloxanes - D4 and D5.

Harvey J Clewell, Melvin E Andersen, Tami S McMullin, 2016, Regulatory toxicology and pharmacology : RTP.

A hybrid CFD-PBPK model for naphthalene in rat and human with IVIVE for nasal tissue metabolism and cross-species dosimetry

M. Andersen, H. Clewell, J. Campbell, 2014, Inhalation toxicology.

Incorporation of pharmacokinetics in noncancer risk assessment: example with chloropentafluorobenzene.

H J Clewell, H. Clewell, B M Jarnot, 1994, Risk analysis : an official publication of the Society for Risk Analysis.

Pharmacodynamic model of the rat estrus cycle in relation to endocrine disruptors.

H J Clewell, M E Andersen, H A Barton, 1997, Journal of toxicology and environmental health.

Development of 3D dynamic flow model of human liver and its application to prediction of metabolic clearance of 7-ethoxycoumarin.

H. Clewell, W. Pfund, ChoiKyoungju, 2014, Tissue engineering. Part C, Methods.

Improving toxicology testing protocols using computer simulations.

H J Clewell, M E Andersen, M. Andersen, 1989, Toxicology letters.

Pharmacokinetics, biochemical mechanism and mutation accumulation: a comprehensive model of chemical carcinogenesis.

H J Clewell, M E Andersen, R B Conolly, 1988, Toxicology letters.

PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals.

M. Jamei, H. Clewell, F. Bois, 2010, Toxicology.

Evaluating placental transfer and tissue concentrations of manganese in the pregnant rat and fetuses after inhalation exposures with a PBPK model.

M. Andersen, H. Clewell, D. Dorman, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

An Analysis of N-Acetylcysteine Treatment for Acetaminophen Overdose Using a Systems Model of Drug-Induced Liver Injury

P. Watkins, M. Andersen, H. Clewell, 2012, Journal of Pharmacology and Experimental Therapeutics.

Improving Risk Assessment: Research Opportunities in Dose Response Modeling to Improve Risk Assessment

D. Dunson, D. Hattis, D. Krewski, 2002 .

Use of in vitro data in developing a physiologically based pharmacokinetic model: Carbaryl as a case study.

G. L. Kedderis, H. Clewell, M. Yoon, 2015, Toxicology.

Evaluation of Physiologically Based Pharmacokinetic Models in Risk Assessment: An Example with Perchloroethylene

M. Andersen, H. Clewell, R. Gentry, 2005, Critical reviews in toxicology.

Temporal concordance between apical and transcriptional points of departure for chemical risk assessment.

Michael B. Black, Dan D. Petersen, Eric Healy, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

The TTC Data Mart: An interactive browser for threshold of toxicological concern calculations

Melvin E. Andersen, Harvey J. Clewell, Patrick D. McMullen, 2020 .

Can the observed association between serum perfluoroalkyl substances and delayed menarche be explained on the basis of puberty-related changes in physiology and pharmacokinetics?

M. Longnecker, J. Xue, M. Andersen, 2015, Environment international.

The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene.

I. Rusyn, A. Knap, H. Clewell, 2015, Toxicological sciences : an official journal of the Society of Toxicology.