R. Clewell

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Physiologically-Based Pharmacokinetic (PBPK) Modeling and Risk Assessment

M. Andersen, H. Clewell, R. Clewell, 2011 .

PBPK model for radioactive iodide and perchlorate kinetics and perchlorate-induced inhibition of iodide uptake in humans.

Rebecca A Clewell, Teresa R Sterner, T. R. Sterner, 2004, Toxicological sciences : an official journal of the Society of Toxicology.

Development of a physiologically based pharmacokinetic model of diisononyl phthalate (DiNP) in pregnant rat and human

Jerry L. Campbell, M. Longnecker, H. Clewell, 2020, Journal of toxicology and environmental health. Part A.

Disposition of diiosononyl phthalate and its effects on sexual development of the male fetus following repeated dosing in pregnant rats.

M. Andersen, R. Clewell, D. Creasy, 2013, Reproductive toxicology.

In vitro metabolism of di(2-ethylhexyl) phthalate (DEHP) by various tissues and cytochrome P450s of human and rat.

Melvin E. Andersen, Harvey J. Clewell, Rebecca A. Clewell, 2012, Toxicology in vitro : an international journal published in association with BIBRA.

Implementing Toxicity Testing in the 21st Century (TT21C): Making safety decisions using toxicity pathways, and progress in a prototype risk assessment.

M. Andersen, R. Clewell, A. White, 2015, Toxicology.

Evaluation of a predictive in vitro Leydig cell assay for anti-androgenicity of phthalate esters in the rat.

Jerry L. Campbell, H. Clewell, R. Clewell, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals.

Menghang Xia, Bas J Blaauboer, Arno C Gutleb, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

Dose-response modeling of etoposide-induced DNA damage response.

M. Andersen, R. Clewell, Qiang Zhang, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment.

H. Clewell, R. Clewell, C. Thompson, 2019, Chemico-biological interactions.

Physiologically Based Pharmacokinetic and Toxicokinetic Models

Harvey, M. Andersen, R. Clewell, 2007 .

PLETHEM – An interactive open-source platform for bridging the source-to-outcome continuum

H. Clewell, R. Clewell, P. McMullen, 2017 .

The role of fit-for-purpose assays within tiered testing approaches: A case study evaluating prioritized estrogen-active compounds in an in vitro human uterotrophic assay.

Chantel I. Nicolas, M. Andersen, K. Mansouri, 2019, Toxicology and applied pharmacology.

Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods.

Melvin E. Andersen, Rebecca A. Clewell, Patrick D. McMullen, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

Addressing systematic inconsistencies between in vitro and in vivo transcriptomic mode of action signatures.

Michael B. Black, M. Andersen, K. Mansouri, 2019, Toxicology in vitro : an international journal published in association with BIBRA.

Considerations for Improving Metabolism Predictions for In Vitro to In Vivo Extrapolation

Chantel I. Nicolas, H. Clewell, R. Clewell, 2022, Frontiers in Toxicology.

Use of mode of action data to inform a dose-response assessment for bladder cancer following exposure to inorganic arsenic.

H. Clewell, R. Clewell, J. Yager, 2014, Toxicology in vitro : an international journal published in association with BIBRA.

Keap1 silencing boosts lipopolysaccharide-induced transcription of interleukin 6 via activation of nuclear factor κB in macrophages.

M. Andersen, R. Clewell, Qiang Zhang, 2013, Toxicology and applied pharmacology.

Case Studies in Cellular Stress: Defining Adversity/Adaptation Tipping Points

Yeyejide A. Adeleye, Russell S. Thomas, I. Shah, 2017 .

Radioiodide in the Male Rat

R. Clewell, P. Robinson, D. Mattie, 2003 .

Suppression of NRF2-ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells.

M. Andersen, R. Clewell, T. Zhou, 2016, Toxicology and applied pharmacology.

In utero exposure to chloroquine alters sexual development in the male fetal rat.

Russell S. Thomas, M. Andersen, R. Clewell, 2009, Toxicology and applied pharmacology.

An in vitro approach to determine the human relevance of anti-spermatogenic effects of 4-methylmorpholine 4-oxide, monohydrate (NMMO) in rat reproductive toxicity studies.

H. Clewell, R. Clewell, R. Gentry, 2022, Toxicology in vitro : an international journal published in association with BIBRA.

Physiologically Based Pharmacokinetic and Toxicokinetic Models

Harvey, M. Andersen, R. Clewell, 2007 .

Assessing Bioactivity-Exposure Profiles of Fruits and Vegetables in the BioMAP Profiling System

Michael B. Black, Bethany B. Parks, E. Berg, 2019 .

Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods

Chantel I. Nicolas, G. Patlewicz, M. Andersen, 2022, Frontiers in Pharmacology.

Contribution of ATM and ATR kinase pathways to p53‐mediated response in etoposide and methyl methanesulfonate induced DNA damage

R. Clewell, Y. Adeleye, Bin Sun, 2017, Environmental and molecular mutagenesis.

Development and specification of physiologically based pharmacokinetic models for use in risk assessment.

Harvey J Clewell, Rebecca A Clewell, H. Clewell, 2008, Regulatory toxicology and pharmacology : RTP.

Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin.

Melvin E Andersen, Rebecca A Clewell, Andrew White, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

Evidence for Competitive Inhibition of Iodide Uptake by Perchlorate and Translocation of Perchlorate into the Thyroid

R. Clewell, P. Robinson, E. Merrill, 2004, International journal of toxicology.

Predicting neonatal perchlorate dose and inhibition of iodide uptake in the rat during lactation using physiologically-based pharmacokinetic modeling.

Rebecca A Clewell, Teresa R Sterner, T. R. Sterner, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Perchlorate Analysis with the AS16 Separation Column

R. Clewell, D. Mattie, J. Eldridge, 2000 .

Predicting fetal perchlorate dose and inhibition of iodide kinetics during gestation: a physiologically-based pharmacokinetic analysis of perchlorate and iodide kinetics in the rat.

Rebecca A Clewell, David R Mattie, Teresa R Sterner, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents.

M. Andersen, R. Clewell, B. Engelward, 2016, Mutation research. Reviews in mutation research.

PBPK predictions of perchlorate distribution and its effect on thyroid uptake of radioiodide in the male rat.

Rebecca A Clewell, David R Mattie, Teresa R Sterner, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

The use of physiologically based models to integrate diverse data sets and reduce uncertainty in the prediction of perchlorate and iodide kinetics across life stages and species

R. Clewell, P. Robinson, E. Merrill, 2001, Toxicology and industrial health.

Physiologically based pharmacokinetic/toxicokinetic modeling.

Harvey J Clewell, Melvin E Andersen, Rebecca A Clewell, 2012, Methods in molecular biology.

A map of the PPARα transcription regulatory network for primary human hepatocytes.

Melvin E Andersen, Rebecca A Clewell, Sudin Bhattacharya, 2014, Chemico-biological interactions.

Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology - Evolution versus revolution.

T Burgdorf, A H Piersma, R Landsiedel, 2019, Toxicology in vitro : an international journal published in association with BIBRA.

A Qualitative Modeling Approach for Whole Genome Prediction Using High-Throughput Toxicogenomics Data and Pathway-Based Validation

Melvin E. Andersen, Patrick D. McMullen, Saad Haider, 2018, Front. Pharmacol..

Multiple receptors shape the estrogen response pathway and are critical considerations for the future of in vitro-based risk assessment efforts

Melvin E. Andersen, Rebecca A. Clewell, Patrick D. McMullen, 2017, Critical reviews in toxicology.

Developing context appropriate toxicity testing approaches using new alternative methods (NAMs).

Harvey J Clewell, Melvin E Andersen, Patrick D McMullen, 2019, ALTEX.

Mode of action studies with phthalate acid monoesters: pharmacokinetic and pharmacodynamic factors affecting steroidogenesis

R. Clewell, 2009 .

Pathway Based Toxicology and Fit-for-Purpose Assays.

Melvin E Andersen, Rebecca A Clewell, Yeyejide Adeleye, 2016, Advances in experimental medicine and biology.

Profiling Dose-Dependent Activation of p53-Mediated Signaling Pathways by Chemicals with Distinct Mechanisms of DNA Damage

Melvin E. Andersen, Rebecca A. Clewell, Patrick D. McMullen, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Adaptive Posttranslational Control in Cellular Stress Response Pathways and Its Relationship to Toxicity Testing and Safety Assessment.

Melvin E Andersen, Rebecca A Clewell, Sudin Bhattacharya, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Editor’s Highlight: Screening ToxCast Prioritized Chemicals for PPARG Function in a Human Adipose-Derived Stem Cell Model of Adipogenesis

Melvin E. Andersen, Michael B. Black, Briana Foley, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Challenges in the application of quantitative approaches in risk assessment: a case study with di-(2-ethylhexyl)phthalate

Harvey J Clewell, Jerry Campbell, P Robinan Gentry, 2011, Critical reviews in toxicology.

An evaluation of the USEPA Proposed Approaches for applying a biologically based dose‐response model in a risk assessment for perchlorate in drinking water

H. Clewell, R. Clewell, R. Gentry, 2019, Regulatory toxicology and pharmacology : RTP.

Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates.

Harvey J Clewell, Melvin E Andersen, Yu-Mei Tan, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

An in vitro approach for prioritization and evaluation of chemical effects on glucocorticoid receptor mediated adipogenesis

Miyoung Yoon, Bethany B. Parks, Briana Foley, 2018, Toxicology and applied pharmacology.

Approaches for characterizing threshold dose-response relationships for DNA-damage pathways involved in carcinogenicity in vivo and micronuclei formation in vitro.

Melvin E Andersen, Rebecca A Clewell, M. Andersen, 2016, Mutagenesis.

Tissue exposures to free and glucuronidated monobutylyphthalate in the pregnant and fetal rat following exposure to di-n-butylphthalate: evaluation with a PBPK model.

Melvin E Andersen, Rebecca A Clewell, Jerry L. Campbell, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Pharmacokinetics of toxic chemicals in breast milk: use of PBPK models to predict infant exposure.

Rebecca A Clewell, Jeffery M Gearhart, R. Clewell, 2002, Environmental health perspectives.

Kinetics of selected di-n-butyl phthalate metabolites and fetal testosterone following repeated and single administration in pregnant rats.

Jerry L. Campbell, M. Andersen, R. Clewell, 2009, Toxicology.

Editor’s Highlight: Development of an In vitro Assay Measuring Uterine-Specific Estrogenic Responses for Use in Chemical Safety Assessment

Jian Dong, Rebecca A. Clewell, Michelle M. Miller, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Perchlorate and Radioiodide Kinetics Across Life Stages in the Human: Using PBPK Models to Predict Dosimetry and Thyroid Inhibition and Sensitive Subpopulations Based on Developmental Stage

Harvey J Clewell, Rebecca A Clewell, David R Mattie, 2007, Journal of toxicology and environmental health. Part A.

Analysis of Trace Level Perchlorate in Drinking Water and Ground Water by Electrospray Mass Spectrometry

R. Clewell, W. Brashear, S. Chaudhuri, 2000 .

Comparison of Rat Hepatocyte 2D-Monocultures and Hepatocytes Non-Parenchymal Cell Co-Cultures for Assessing Chemical Toxicity

Michael B. Black, Aarati R. Ranade, M. Andersen, 2022, International journal of toxicology.

Evaluating opportunities for advancing the use of alternative methods in risk assessment through the development of fit-for-purpose in vitro assays.

Harvey J Clewell, Melvin E Andersen, Martin B Phillips, 2018, Toxicology in vitro : an international journal published in association with BIBRA.

Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system.

Harvey J Clewell, Melvin E Andersen, Salil N Pendse, 2019, Toxicology in vitro : an international journal published in association with BIBRA.

A dose response study to assess effects after dietary administration of diisononyl phthalate (DINP) in gestation and lactation on male rat sexual development.

M. Andersen, R. Clewell, D. Creasy, 2013, Reproductive toxicology.

Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals.

R. Kavlock, K. Crofton, M. Xia, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

Structural alerts and Machine learning modeling of “Six-pack” toxicity as alternative to animal testing

R. Clewell, J. Gearhart, Y. Chushak, 2023, Computational Toxicology.

In utero exposure to chloroquine alters sexual development in the male fetal rat.

Russell S. Thomas, M. Andersen, R. Clewell, 2009, Toxicology and applied pharmacology.

Predicting neonatal perchlorate dose and inhibition of iodide uptake in the rat during lactation using physiologically-based pharmacokinetic modeling.

T. R. Sterner, R. Clewell, J. Fisher, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

The TTC Data Mart: An interactive browser for threshold of toxicological concern calculations

Melvin E. Andersen, Harvey J. Clewell, Patrick D. McMullen, 2020 .

Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents.

Christopher D. Heinen, Yeyejide A. Adeleye, M. Andersen, 2016, Mutation research. Reviews in mutation research.

Predicting Neonatal Perchlorate Dose and Inhibition of Iodide Uptake in the Rat during Lactation Using Physiologically-Based Pharmacokinetic Modeling

T. R. Sterner, R. Clewell, E. Merrill, 2003 .