J. Trudell

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Homology Modeling of a Human Glycine Alpha 1 Receptor Reveals a Plausible Anesthetic Binding Site

Douglas L. Brutlag, James R. Trudell, Edward J. Bertaccini, 2005, J. Chem. Inf. Model..

Noncompetitive antagonist binding sites in the torpedo nicotinic acetylcholine receptor ion channel. Structure-activity relationship studies using adamantane derivatives.

J. Trudell, M. P. Blanton, H. Arias, 2003, Biochemistry.

Anesthetics and ion channels: molecular models and sites of action.

E. Bertaccini, J. Trudell, T. Yamakura, 2001, Annual review of pharmacology and toxicology.

Cross‐linking of glycine receptor transmembrane segments two and three alters coupling of ligand binding with channel opening

J. Trudell, I. Lobo, R. A. Harris, 2004, Journal of neurochemistry.

Tryptophan scanning mutagenesis in TM4 of the GABAA receptor α1 subunit: implications for modulation by inhaled anesthetics and ion channel structure

J. Trudell, A. Jenkins, Alyson Andreasen, 2002, Neuropharmacology.

Minimum alveolar anesthetic concentration of fluorinated alkanols in rats: relevance to theories of narcosis.

A. Pohorille, E. Eger, J. Trudell, 1999, Anesthesia and analgesia.

Molecular modeling of ligand-gated ion channels: progress and challenges.

E. Bertaccini, J. Trudell, 2001, International review of neurobiology.

Predicting the transmembrane secondary structure of ligand-gated ion channels.

E. Bertaccini, J. Trudell, 2002, Protein engineering.

Molecular modelling of specific and non-specific anaesthetic interactions.

E. Bertaccini, J. Trudell, 2002, British journal of anaesthesia.

Evidence for a Common Binding Cavity for Three General Anesthetics within the GABAA Receptor

H. Faulkner, E. Bertaccini, J. Trudell, 2001, The Journal of Neuroscience.

Comparative modeling of a GABAA alpha1 receptor using three crystal structures as templates.

E. Bertaccini, J. Trudell, 2004, Journal of molecular graphics & modelling.

Inhaled Anesthetics and Immobility: Mechanisms, Mysteries, and Minimum Alveolar Anesthetic Concentration

B. Orser, B. Vissel, E. Eger, 2003, Anesthesia and analgesia.

Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor.

Björn Wallner, Erik Lindahl, Samuel Murail, 2011, Biophysical journal.

Ethanol Inhibition of Constitutively Open N-Methyl-d-Aspartate Receptors

J. Trudell, J. Woodward, M. Xu, 2012, Journal of Pharmacology and Experimental Therapeutics.

Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites.

E. Lindahl, J. Trudell, R. Harris, 2013, Structure.

Emerging molecular mechanisms of general anesthetic action.

B. Orser, J. Trudell, M. Akabas, 2005, Trends in pharmacological sciences.

Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors

J. Trudell, D. Davies, L. Asatryan, 2013, Purinergic Signalling.

Stabilization of the GluCl ligand-gated ion channel in the presence and absence of ivermectin.

Erik Lindahl, Ozge Yoluk, E. Lindahl, 2013, Biophysical journal.

The Common Chemical Motifs Within Anesthetic Binding Sites

E. Bertaccini, J. Trudell, N. Franks, 2007, Anesthesia and analgesia.

Conversion of leukotriene A4 to leukotriene B4: catalysis by human liver microsomes under anaerobic conditions.

J. Gut, J. Trudell, G. Jamieson, 1987, Archives of biochemistry and biophysics.

Inter- and Intra-Subunit Butanol/Isoflurane Sites of Action in the Human Glycine Receptor

J. Trudell, R. Harris, R. Mayfield, 2016, Front. Mol. Neurosci..

Assessment of Homology Templates and an Anesthetic Binding Site within the &ggr;-Aminobutyric Acid Receptor

E. Lindahl, E. Bertaccini, J. Trudell, 2013, Anesthesiology.

Molecular targets and mechanisms for ethanol action in glycine receptors.

J. Trudell, D. Crawford, D. Davies, 2010, Pharmacology & therapeutics.

Cross‐linking of sites involved with alcohol action between transmembrane segments 1 and 3 of the glycine receptor following activation

J. Trudell, R. Harris, I. Lobo, 2008, Journal of neurochemistry.

Structural elements involved in activation of the γ-aminobutyric acid type A (GABAA) receptor

J. Trudell, N. Harrison, T. Kash, 2004 .

Structural elements involved in activation of the gamma-aminobutyric acid type A (GABAA) receptor.

J. Trudell, N. Harrison, T. Kash, 2004, Biochemical Society transactions.

Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors.

M. Balog, T. Kálai, K. Hideg, 2014, European journal of medicinal chemistry.

Magnetic circular dichroism of purified forms of rabbit liver cytochromes P-450 and P-420.

C. Djerassi, J. Trudell, J. Dawson, 1978, Biochemistry.

Alcohol dependence: molecular and behavioral evidence.

J. Trudell, R. Harris, J. Mayfield, 2014, Trends in pharmacological sciences.

The compression-ordering and solubility-disordering effects of high pressure gases on phospholipid bilayers.

J. Trudell, J. H. Chin, E. N. Cohen, 1976, Life sciences.

Endothelial Fate Mapping in Mice With Pulmonary Hypertension

G. Berry, T. Nishimura, J. Trudell, 2014, Circulation.

Oxygen concentration-dependent metabolism of leukotriene B4 by hepatocyte monolayers.

J. Gut, J. Trudell, A. K. Costa, 1986, Biochimica et biophysica acta.

Expression of bcl-2 inhibits cellular radical generation.

D. Bredesen, J. Trudell, C. Altenbach, 1996, Free radical research.

Urinary Metabolites of Halothane in Man

J. Trudell, E. N. Cohen, E. Watson, 1975, Anesthesiology.

Methoxyflurane Metabolism and Renal Dysfunction: Clinical Correlation in Man

J. Trudell, M. Cousins, R. Mazze, 1971, Anesthesiology.

Toxicity of 1,2-dibromoethane in primary hepatocyte monolayer cultures: lack of dependence on oxygen concentration.

J. Trudell, A. K. Costa, 1988, Toxicology and applied pharmacology.

Association of cytochrome b5 and cytochrome P-450 reductase with cytochrome P-450 in the membrane of reconstituted vesicles.

J. Trudell, B. Bösterling, 1982, The Journal of biological chemistry.

Reconstitution of cytochrome P-450 and cytochrome P-450 reductase into phosphatidylcholine-phosphatidylethanolamine bilayers: characterization of structure and metabolic activity.

J. Trudell, J. Dawson, A. Stier, 1979, Molecular pharmacology.

Phospholipid transfer between vesicles. Dependence on presence of cytochrome P-450 and phosphatidylcholine-phosphatidylethanolamine ratio.

J. Trudell, B. Bösterling, B. Bösterling, 1982, Biochimica et biophysica acta.

Phospholipid interactions with cytochrome P-450 in reconstituted vesicles. Preference for negatively-charged phosphatidic acid.

J. Trudell, H. Galla, B. Bösterling, 1981, Biochimica et biophysica acta.

Toxicity oft-butylhydroperoxide in hepatocyte monolayers exposed to hypoxia and reoxygenation

J. Trudell, T. Schieble, D. Heffel, 1987, In Vitro Cellular & Developmental Biology.

Hypoxia potentiates killing of hepatocyte monolayers by leukotrienes, hydroperoxyeicosatetraenoic acids, or calcium ionophore A23187.

J. Trudell, M. Bendix, B. Bosterling, 1984, Biochimica et biophysica acta.

Chapter 6 – Interactions of Cytochrome P-450 with Phospholipids and Proteins in the Endoplasmic Reticulum1

J. Trudell, B. Bösterling, 1983 .

Induction of HSP72 in rat liver by chronic ethanol consumption combined with exercise: association with the prevention of ethanol-induced fatty liver by exercise.

J. Trudell, C. Ardies, D. Chrystof, 1995, Alcoholism, clinical and experimental research.

Molecular modelling of speciﬁc and non-speciﬁc anaesthetic interactions

E. Bertaccini, J. Trudell, 2022 .

Avermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders.

J. Trudell, N. Petasis, S. Louie, 2014, The international journal of neuropsychopharmacology.

IVERMECTIN ANTAGONIZES ETHANOL INHIBITION IN P2X4 RECEPTORS

J. Trudell, D. Davies, L. Asatryan, 2010 .

Residues in Transmembrane Segments of the P2X4 Receptor Contribute to Channel Function and Ethanol Sensitivity

J. Trudell, D. Davies, L. Asatryan, 2020, International journal of molecular sciences.

THE EFFECT OF HIGH PRESSURE ON PHOSPHOLIPID BILAYER MEMBRANES

J. Trudell, 1976 .

Leukotriene biosynthesis: direct chemical ionization mass spectrometry of underivatized arachidonic acid metabolites.

J. Gut, J. Trudell, G. Jamieson, 1988, Biomedical & environmental mass spectrometry.

How Do Volatile Agents Produce Anesthesia

J. Trudell, 1986 .

Toxicity of styrene vapor in hepatocyte monolayers at low oxygen tensions.

J. Trudell, A. K. Costa, 1990, Environmental health perspectives.

Interaction of hypoxia and carbon tetrachloride toxicity in hepatocyte monolayers.

J. Trudell, A. K. Costa, 1989, Experimental and molecular pathology.

Toxicity of calcium ionophore A23187 in monolayers of hypoxic hepatocytes.

J. Trudell, T. Schieble, D. Heffel, 1987, Toxicology and applied pharmacology.

Magnetic circular dichroism of ferrous carbonyl adducts of cytochromes P-450 and P-420 and their synthetic models: further evidence for mercaptide as the fifth ligand to iron.

C. Djerassi, J. Trudell, J. Dawson, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Charge and Geometry of Residues in the Loop 2 β Hairpin Differentially Affect Agonist and Ethanol Sensitivity in Glycine Receptors

J. Trudell, D. Davies, L. Asatryan, 2012, Journal of Pharmacology and Experimental Therapeutics.

Quantification of 5- and 15-HPETE's by direct chemical ionization mass spectrometry.

J. Gut, J. Trudell, G. Jamieson, 1987, Free radical biology & medicine.

Properties of enzymes in hepatocytes that convert 5-HPETE or LTA4 into LTB4.

J. Gut, J. Trudell, 1989, Free radical biology & medicine.

Pressure-induced elevation of phase transition temperature in dipalmitoylphosphatidylcholine bilayers. An electron spin resonance measurement of the enthalpy of phase transition.

J. Trudell, D. Payan, J. H. Chin, 1974, Biochimica et biophysica acta.

The Effect of Alcohol and Anesthetic Metabolites on Cell Membranes

J. Trudell, C. Ardies, W. Anderson, 1991, Annals of the New York Academy of Sciences.

Binding of anti-acetaldehyde IgG antibodies to hepatocytes with an acetaldehyde-phosphatidylethanolamine adduct on their surface.

J. Trudell, C. Ardies, C. Green, 1991, Alcoholism, clinical and experimental research.

Linking of Glycine Receptor Transmembrane Segments Three and Four Allows Assignment of Intrasubunit-Facing Residues.

J. Trudell, R. Harris, D. Gong, 2010, ACS chemical neuroscience.

Molecular mechanisms and binding site location for the noncompetitive antagonist crystal violet on nicotinic acetylcholine receptors.

J. Trudell, H. Arias, C. Bouzat, 2006, Biochemistry.

Hypothesis: Inhaled Anesthetics Produce Immobility and Amnesia by Different Mechanisms at Different Sites

A. Pohorille, E. Eger, J. Trudell, 1997, Anesthesia and analgesia.

Carbohydrate digestion by the domestic cat (Felis catus)

J. Trudell, J. Morris, J. Trudell, 1977, British Journal of Nutrition.

Mass spectrometry in structural and stereochemical problems—CLXXXVII A study of skeletal rearrangements in chromans by combined 13C and deuterium labeling†‡

C. Djerassi, J. Trudell, S. D. Woodgate, 1970 .

The effect of two inhalation anesthetics on the order of spin-labeled phospholipid vesicles.

J. Trudell, W. Hubbell, E. N. Cohen, 1973, Biochimica et biophysica acta.

Is there light at the end of the tunnel?

J. Trudell, 1985, Anesthesia and analgesia.

P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders

J. Trudell, M. Jakowec, K. Franklin, 2014, Front. Neurosci..

Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution.

J. Trudell, R. Harris, P. Slesinger, 2011, Alcoholism, clinical and experimental research.

Targets for ethanol action and antagonism in Loop 2 of the extracellular domain of glycine receptors

J. Trudell, D. Crawford, D. Davies, 2008, Journal of neurochemistry.

Intramolecular determination of primary kinetic isotope effects in hydroxylations catalyzed by cytochrome P-450.

J. Trudell, J R Trudell, L. Hjelmeland, 1977, Biochemical and biophysical research communications.

Pressure-induced changes in the molecular organization of a lipid-peptide complex: polymyxin binding to phosphatidic acid membranes.

J. Trudell, H. Galla, H. Franke, 1980, Biochimica et biophysica acta.

Antagonism of membrane compression effects by high pressure gas mixtures in a phospholipid bilayer system.

J. Trudell, E. N. Cohen, C. Mastrangelo, 1978, Life sciences.

Comparative Toxicity of Halothane, Isoflurane, Hypoxia, and Phenobarbital Induction in Monolayer Cultures of Rat Hepatocytes

J. Trudell, T. Schieble, D. Heffel, 1988, Anesthesiology.

Reductive metabolism of carbon tetrachloride by human cytochromes P-450 reconstituted in phospholipid vesicles: mass spectral identification of trichloromethyl radical bound to dioleoyl phosphatidylcholine.

J. Trudell, A. Trevor, B. Bösterling, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Molecular mechanisms of anaesthesia and cerebral cell signal transduction during anaesthesia with special regard to halogenated anaesthetics

J. Trudell, 1993 .

Letter: Oxidized cytochrome P-450. Magnetic circular dichroism evidence for thiolate ligation in the substrate-bound form. Implications for the catalytic mechanism.

C. Djerassi, J. Trudell, J. Dawson, 1976, Journal of the American Chemical Society.

Metabolism of Isoflurane in Fischer 344 Rats and Man

B. Hitt, G. Barr, J. Trudell, 1974, Anesthesiology.

Asymmetric antagonistic effects of an inhalation anesthetic and high pressure on the phase transition temperature of dipalmitoyl phosphatidic acid bilayers.

J. Trudell, H. Galla, J R Trudell, 1980, Biochimica et biophysica acta.

Pressure Reversal of Anesthesia: The Extent of Small-molecule Exclusion from Spin-labeled Phospholipid Model Membranes

J. Trudell, W. Hubbell, E. N. Cohen, 1973, Anesthesiology.

Unique general anesthetic binding sites within distinct conformational states of the nicotinic acetylcholine receptor.

J. Trudell, M. P. Blanton, H. Arias, 2003, International review of neurobiology.

Magnetic circular dichroism studies. 43. Oxidized cytochrome P-450. Magnetic circular dichroism evidence for thiolate ligation in the substrate-bound form. Implications for the catalytic mechanism

Carl Djerassi, James R. Trudell, Robert E. Linder, 1976 .

Letter: Chloroperoxidase. Evidence for P-450 type heme environment from magnetic circular dichroism spectroscopy.

C. Djerassi, J. Trudell, J. Dawson, 1976, Journal of the American Chemical Society.

The effect of pressure on the phase diagram of mixed dipalmitoyl-dimyristoylphosphatidylcholine bilayers.

J. Trudell, D. Payan, J. H. Chin, 1974, Biochimica et biophysica acta.

A Unitary Theory of Anesthesia Based on Lateral Phase Separations in Nerve Membranes

J. Trudell, J R Trudell, 1977, Anesthesiology.

Formation of free radical intermediates during nitrous oxide metabolism by human intestinal contents.

J. Trudell, E. N. Cohen, K. Hong, 1980, Biochemical pharmacology.

Volatile Metabolites and Decomposition Products of Halothane In Man

J. Trudell, J. Sharp, E. N. Cohen, 1979, Anesthesiology.

Biotransformation of Nitrous Oxide Reply

J. Trudell, J. R. O'neil, E. N. Cohen, 1980 .

Contributions of dipole moments, quadrupole moments, and molecular polarizabilities to the anesthetic potency of fluorobenzenes.

J. Trudell, 1998, Biophysical chemistry.

Modeling Anesthetic Binding Sites within the Glycine Alpha One Receptor Based on Prokaryotic Ion Channel Templates: The Problem with TM4

Björn Wallner, Erik Lindahl, James R. Trudell, 2010, J. Chem. Inf. Model..

Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation

E. Bertaccini, J. Trudell, S. Mihic, 2010, Proceedings of the National Academy of Sciences.

A Molecular Description of How Noble Gases and Nitrogen Bind to a Model Site of Anesthetic Action

E. Eger, J. Trudell, D. Koblin, 1998, Anesthesia and analgesia.

Chronic exposure to anesthetic gases in the operating room.

J. Trudell, C. Whitcher, E. N. Cohen, 1971, Anesthesiology.

1460 – VOLATILE METABOLITES AND DECOMPOSITION PRODUCTS OF HALOTHANE

J. Trudell, J. Sharp, E. N. Cohen, 1978 .

Binding of Halothane‐free Radicals to Fatty Acids Following: UV Irradiation

J. Trudell, A. Trevor, B. Bösterling, 1982, Anesthesiology.

Ethanol’s Molecular Targets

J. Trudell, R. Harris, S. Mihic, 2008, Science Signaling.

Lipid-protein interactions as determinants of activation or inhibition by cytochrome b5 of cytochrome P-450-mediated oxidations.

J. Trudell, A. Trevor, B. Bösterling, 1982, The Journal of biological chemistry.

Hypothesis: volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart.

A. Pohorille, E. Eger, J. Trudell, 1999, Anesthesia and analgesia.

Metabolism of volatile anesthetics: Implications for toxicity

J. Trudell, E. N. Cohen, R. Dyke, 1977 .

Teaching an Old GABA Receptor New Tricks

E. Bertaccini, J. Trudell, M. MacIver, 2012, Anesthesia and analgesia.

The antagonistic effect of an inhalation anesthetic and high pressure on the phase diagram of mixed dipalmitoyl-dimyristoylphosphatidylcholine bilayers.

J. Trudell, D. Payan, J. H. Chin, 1975, Proceedings of the National Academy of Sciences of the United States of America.

1-Chloro-2,2,2-trifluoroethyl radical: Formation from halothane by human cytochrome P-450 in reconstituted vesicles and binding to phospholipids.

J. Trudell, A. Trevor, Bösterling, 1981, Biochemical and biophysical research communications.

Halothane Stereoisomers: Lack of Slereospecificity in Two Model Systems

J. Trudell, E. N. Cohen, J. Kendig, 1973, Anesthesiology.

Channel Gating of the Glycine Receptor Changes Accessibility to Residues Implicated in Receptor Potentiation by Alcohols and Anesthetics*

J. Trudell, R. Harris, I. Lobo, 2004, Journal of Biological Chemistry.

Effect of clinical concentrations of halothane on phospholipid-cholesterol membrane fluidity.

J. Trudell, E. N. Cohen, H. N. Edmunds, 1978, Molecular pharmacology.

Quantum chemical studies of the metabolism of the inhalation anesthetics methoxyflurane, enflurane, and isoflurane.

J. Trudell, G. Loew, E. Cohen, 1974, Molecular pharmacology.

Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol

J. Trudell, G. Homanics, J. Trang, 2015, Neuroscience.

Ivermectin Antagonizes Ethanol Inhibition in Purinergic P2X4 Receptors

J. Trudell, D. Davies, L. Asatryan, 2010, Journal of Pharmacology and Experimental Therapeutics.

Seeking Structural Specificity: Direct Modulation of Pentameric Ligand-Gated Ion Channels by Alcohols and General Anesthetics

J. Trudell, R. Harris, R. Howard, 2014, Pharmacological Reviews.

Charged Residues in the β2 Subunit Involved in GABAA Receptor Activation*

J. Trudell, N. Harrison, T. Kash, 2004, Journal of Biological Chemistry.

Coupling of agonist binding to channel gating in the GABAA receptor

J. Trudell, A. Jenkins, N. Harrison, 2003, Nature.

An intersubunit electrostatic interaction in the GABAA receptor facilitates its responses to benzodiazepines

J. Trudell, S. Mihic, Anna W. Daszkowski, 2018, The Journal of Biological Chemistry.

A Novel Hyperekplexia-causing Mutation in the Pre-transmembrane Segment 1 of the Human Glycine Receptor α1 Subunit Reduces Membrane Expression and Impairs Gating by Agonists*

J. Trudell, N. Harrison, L. Annunziato, 2004, Journal of Biological Chemistry.

Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor?

J. Trudell, R. Harris, N. Harrison, 1998, Proceedings of the National Academy of Sciences of the United States of America.

In vitro hepatotoxicity of SR 4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide), a hypoxic cytotoxin and potential antitumor agent.

J. Trudell, A. K. Costa, M. A. Baker, 1989, Cancer research.

Pressure reversal of inhalation anesthetic-induced disorder in spin-labeled phospholipid vesicles.

J. Trudell, W. Hubbell, W L Hubbell, 1973, Biochimica et biophysica acta.

Binding of anti-trifluoroacetyl antibodies to isolated hepatocytes observed by digital fluorescence microscopy.

J. Trudell, A. Stier, M. Niederstadt, 1994, Biochemical and biophysical research communications.

Nuclear translocation of heat shock protein 72 in liver cells of halothane-exposed rats.

J. Trudell, R. V. Van dyke, H. Marsh, 1994, Biochemical and biophysical research communications.

Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of α1 glycine receptors

E. Bertaccini, J. Trudell, D. Crawford, 2007, Journal of neurochemistry.

The membrane volume occupied by anesthetic molecules: a reinterpretation of the erythrocyte expansion data.

J. Trudell, 1977, Biochimica et biophysica acta.

An improved monobromobimane assay for glutathione utilizing tris- (2-carboxyethyl)phosphine as the reductant.

L A Herzenberg, D. Voehringer, J. Trudell, 1999, Analytical biochemistry.

Molecular Modeling of a Tandem Two Pore Domain Potassium Channel Reveals a Putative Binding Site for General Anesthetics

E. Bertaccini, J. Trudell, R. Dickinson, 2014, ACS chemical neuroscience.

Sites of Volatile Anesthetic Action on Kainate (Glutamate Receptor 6) Receptors*

J. Trudell, R. Harris, M. Wick, 1998, The Journal of Biological Chemistry.

Loop 2 Structure in Glycine and GABAA Receptors Plays a Key Role in Determining Ethanol Sensitivity*

J. Trudell, D. Crawford, D. Davies, 2009, The Journal of Biological Chemistry.

Evaluation of a proposed mechanism of ligand-gated ion channel activation in the GABAA and glycine receptors

J. Trudell, N. Harrison, T. Kash, 2004, Neuroscience Letters.

Nerve membrane lipid fluidity: opposing effects of high pressure and ethanol.

J. Trudell, J J Kendig, J R Trudell, 1979, Undersea biomedical research.

Minimum alveolar concentrations of noble gases, nitrogen, and sulfur hexafluoride in rats : Helium and neon as nonimmobilizers (nonanesthetics)

E. Eger, J. Trudell, D. Koblin, 1998 .

Multiple sites of ethanol action in α1 and α2 glycine receptors suggested by sensitivity to pressure antagonism

J. Trudell, S. Mihic, D. Crawford, 2004 .

Ethanol potentiation of glycine receptors expressed in Xenopus oocytes antagonized by increased atmospheric pressure.

J. Trudell, S. Mihic, D. Crawford, 2003, Alcoholism, clinical and experimental research.

Mutation of a Zinc-Binding Residue in the Glycine Receptor α1 Subunit Changes Ethanol Sensitivity In Vitro and Alcohol Consumption In Vivo

J. Trudell, R. Harris, H. Betz, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor alpha 1 subunit: critical residues for activation and modulation.

J. Trudell, N. Harrison, C. M. Schofield, 2004, Biochemistry.

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

Erik Lindahl, Pierre-Jean Corringer, Samuel Murail, 2011, Proceedings of the National Academy of Sciences.

Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism.

J. Trudell, S. Mihic, D. Crawford, 2004, Journal of neurochemistry.

Glycine and GABAA Ultra-Sensitive Ethanol Receptors as Novel Tools for Alcohol and Brain Research

J. Trudell, G. Homanics, D. Davies, 2014, Molecular Pharmacology.

Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol.

E. Lindahl, R. Olsen, E. Bertaccini, 2014, Alcoholism, clinical and experimental research.

Zinc-dependent modulation of α2- and α3-glycine receptor subunits by ethanol.

J. Trudell, R. Harris, M. McCracken, 2013, Alcoholism, clinical and experimental research.

Zinc enhances ethanol modulation of the α1 glycine receptor

J. Trudell, R. Harris, S. Mihic, 2010, Neuropharmacology.

MANIPULATIONS OF EXTRACELLULAR LOOP 2 IN a 1 GLYR ULTRASENSITIVE ETHANOL RECEPTORS ( USERS ) ENHANCE RECEPTOR SENSITIVITY TO ISOFLURANE , ETHANOL , AND LIDOCAINE , BUT NOT

J. Trudell, G. Homanics, J. Trang, 2015 .

Characterization of Two Mutations, M287L and Q266I, in the α1 Glycine Receptor Subunit That Modify Sensitivity to Alcohols

D. Lovinger, J. Trudell, R. Harris, 2012, Journal of Pharmacology and Experimental Therapeutics.

Roles for Loop 2 Residues of α1 Glycine Receptors in Agonist Activation*

E. Bertaccini, J. Trudell, D. Crawford, 2008, Journal of Biological Chemistry.

Criteria for an Ethanol Molecular Target

J. Trudell, R. Harris, S. Mihic, 2009 .

Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors

J. Trudell, D. Davies, L. Asatryan, 2013, Purinergic Signalling.

Luciferase as a Model for the Site of Inhaled Anesthetic Action

E. Eger, R. Dutton, J. Trudell, 2001, Anesthesia and analgesia.

Sites of Excitatory and Inhibitory Actions of Alcohols on Neuronal α2β4 Nicotinic Acetylcholine Receptors

J. Trudell, R. Harris, C. Hodgkinson, 2003, Journal of Pharmacology and Experimental Therapeutics.

Sites of excitatory and inhibitory actions of alcohols on neuronal alpha2beta4 nicotinic acetylcholine receptors.

J. Trudell, R. Harris, L. Henderson, 2003, The Journal of pharmacology and experimental therapeutics.

Induced changes in protein receptors conferring resistance to anesthetics

E. Bertaccini, J. Trudell, 2012, Current opinion in anaesthesiology.

Effect of Cobratoxin Binding on the Normal Mode Vibration within Acetylcholine Binding Protein

Erik Lindahl, James R. Trudell, Edward J. Bertaccini, 2008, J. Chem. Inf. Model..

Normal-Mode Analysis of the Glycine Alpha1 Receptor by Three Separate Methods

Erik Lindahl, James R. Trudell, Edward J. Bertaccini, 2007, J. Chem. Inf. Model..

Normal mode analysis reveals the channel gating motion within a ligand gated ion channel model

E. Lindahl, E. Bertaccini, J. Trudell, 2005 .

Inhibition of protein kinase C phosphorylation by mono- and divalent cations.

J. Trudell, A. K. Costa, C. Csernansky, 1989, Biochemical and biophysical research communications.

Specific binding sites for alcohols and anesthetics on ligand-gated ion channels.

J. Trudell, R. Harris, M. P. Mascia, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Unique assignment of inter-subunit association in GABAA α1β3γ2 receptors determined by molecular modeling

J. Trudell, 2002 .

Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors.

Evan P. Stater, J. Trudell, P. Corringer, 2015, Alcoholism, clinical and experimental research.

Molecular Mechanism for the Dual Alcohol Modulation of Cys-loop Receptors

Erik Lindahl, James R. Trudell, Edward J. Bertaccini, 2012, PLoS Comput. Biol..

A Transmembrane Amino Acid in the GABAA Receptor β2 Subunit Critical for the Actions of Alcohols and Anesthetics

J. Trudell, R. Harris, M. McCracken, 2010, Journal of Pharmacology and Experimental Therapeutics.

ELECTRON SPIN RESONANCE STUDIES WITH THE VOLATILE ANESTHETICS ON PHOSPHOLIPID MODEL MEMBRANES *

J. Trudell, W. Hubbell, E. N. Cohen, 1973, Annals of the New York Academy of Sciences.

Effects of pressure and anesthetics on conduction and synaptic transmission.

J. Trudell, J J Kendig, J R Trudell, 1975, The Journal of pharmacology and experimental therapeutics.

Cross-reactivity of antibodies raised against acetaldehyde adducts of protein with acetaldehyde adducts of phosphatidyl-ethanolamine: possible role in alcoholic cirrhosis.

J. Trudell, C. Ardies, W. Anderson, 1990, Molecular pharmacology.

Spin trap evidence for production of superoxide radical anions by purified NADPH-cytochrome P-450 reductase.

J. Trudell, B. Bösterling, 1981, Biochemical and biophysical research communications.

The TM2 6′ Position of GABAA Receptors Mediates Alcohol Inhibition

J. Trudell, R. Harris, R. Howard, 2012, Journal of Pharmacology and Experimental Therapeutics.

Modulation of α1β3γ2 GABAA receptors expressed in X. laevis oocytes using a propofol photoswitch tethered to the transmembrane helix

E. Bertaccini, J. Trudell, R. Harris, 2021, Proceedings of the National Academy of Sciences of the United States of America.

Structural elements governing activation and modulation of GABAA receptors

J. Trudell, A. Jenkins, N. Harrison, 2005 .

Actions of fluorinated alkanols on GABA(A) receptors: relevance to theories of narcosis.

E. Eger, J. Trudell, R. Harris, 1999, Anesthesia and analgesia.

Accessibility to residues in transmembrane segment four of the glycine receptor

J. Trudell, R. Harris, I. Lobo, 2006, Neuropharmacology.

Ethyl acetate extraction of spin-trapped free radicals: a reevaluation.

J. Trudell, 1987, Free radical biology & medicine.

Identification of an Inhibitory Alcohol Binding Site in GABAA ρ1 Receptors.

E. Bertaccini, J. Trudell, R. Harris, 2016, ACS chemical neuroscience.

Actions of Fluorinated Alkanols on GABAA Receptors

E. Eger, J. Trudell, R. Harris, 1999 .

Are sobriety and consciousness determined by water in protein cavities?

J. Trudell, R. Harris, 2004, Alcoholism, clinical and experimental research.

Identifying the binding site(s) for antidepressants on the Torpedo nicotinic acetylcholine receptor: [3H]2-azidoimipramine photolabeling and molecular dynamics studies.

J. Trudell, M. P. Blanton, H. Arias, 2008, Biochimica et biophysica acta.

General Anesthetics Have Additive Actions on Three Ligand Gated Ion Channels

E. Eger, J. Trudell, R. Harris, 2008, Anesthesia and analgesia.

Minimum Alveolar Concentrations of Noble Gases, Nitrogen, and Sulfur Hexafluoride in Rats: Helium and Neon as Nonimmobilizers (Nonanesthetics)

E. Eger, J. Trudell, D. Koblin, 1998, Anesthesia and analgesia.

Metabolism of Nitrous Oxide by Human and Rat Intestinal Contents

J. Trudell, J. R. O'neil, E. N. Cohen, 1979, Anesthesiology.

Inhibition of Protein Kinase C by Local Anesthetics

J. Trudell, W. Hubbell, JAMES R. TRUDELL, 1991, Annals of the New York Academy of Sciences.

The Anesthetic Potencies of Alkanethiols for Rats: Relevance to Theories of Narcosis

E. Eger, J. Trudell, M. Laster, 2000, Anesthesia and analgesia.

Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors.

M. Balog, T. Kálai, K. Hideg, 2014, European journal of medicinal chemistry.

Concentration measures of volatile anesthetics in the aqueous phase using calcium sensitive electrodes

R. Pearce, J. Trudell, C. E. Hagan, 1998, Journal of Neuroscience Methods.

Evidence for leukotriene A4 as an intermediate in the conversion of 5-HPETE to leukotriene B4 catalyzed by cytochrome P-450.

J. Trudell, B. Bösterling, 1983, Biochemical and biophysical research communications.

Magnetic circular dichroism studies. XXV. A preliminary investigation of microsomal cytochromes.

C. Djerassi, J. Trudell, E. Bunnenberg, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Stabilization of the GluCl ligand-gated ion channel in the presence and absence of ivermectin.

E. Lindahl, E. Bertaccini, J. Trudell, 2013, Biophysical journal.

Anesthetic and ethanol effects on spontaneously opening glycine receptor channels

J. Trudell, S. Mihic, M. Beckstead, 2002, Journal of neurochemistry.

The Minimum Alveolar Anesthetic Concentration of 2-, 3-, and 4-Alcohols and Ketones in Rats: Relevance to Anesthetic Mechanisms

E. Eger, J. Trudell, M. Laster, 2006, Anesthesia and analgesia.

Localization of molecular halothane in phospholipid bilayer model nerve membranes.

J. Trudell, W. Hubbell, 1976, Anesthesiology.

Roles for Loop 2 Residues of α1 Glycine Receptors in Agonist Activation*

E. Bertaccini, J. Trudell, D. Crawford, 2008, Journal of Biological Chemistry.

Zinc-dependent modulation of α2- and α3-glycine receptor subunits by ethanol.

J. Trudell, Lindsay M. McCracken, Mandy L. McCracken, 2013, Alcoholism, clinical and experimental research.

Mutation of a Zinc-Binding Residue in the Glycine Receptor α1 Subunit Changes Ethanol Sensitivity In Vitro and Alcohol Consumption In Vivo

J. Trudell, H. Betz, Y. Blednov, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Leukotriene B4 metabolism by hepatic cytochrome P-450.

J. Trudell, B. Bösterling, 1983, Biochemical and biophysical research communications.