P. Weber

发表

Structure of ferricytochrome c' from Rhodospirillum molischianum at 1.67 A resolution.

B. Finzel, P. Weber, K. D. Hardman, 1985, Journal of molecular biology.

Structural origins of high-affinity biotin binding to streptavidin.

J. Wendoloski, P. Weber, F. Salemme, 1989, Science.

Preliminary crystallographic data for cross-linked (lysine7-lysine41)-ribonuclease A.

H. Scheraga, Y. Konishi, P. Weber, 1985, Journal of molecular biology.

The electrostatic profile of consecutive Cβ atoms applied to protein structure quality assessment

Shina Caroline Lynn Kamerlin, P. Weber, B. Rao, 2013, F1000Research.

New inhibitors of thrombin and other trypsin-like proteases: hydrogen bonding of an aromatic cyano group with a backbone amide of the P1 binding site replaces binding of a basic side chain.

P. Weber, R. Trievel, R. Alexander, 1997, Biochemistry.

Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation

P. Weber, T. Fischmann, S. Narula, 1999, Nature Structural Biology.

Structural and functional diversity in 4-α-helical proteins

F. R. Salemme, P. Weber, F. Salemme, 1980, Nature.

Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry.

J. M. Sauder, P. Weber, F. Lu, 2010, Journal of molecular biology.

Experiments with automated protein crystallization

P. C. Weber, P. Weber, M. Cox, 1987 .

Applications of calorimetric methods to drug discovery and the study of protein interactions.

Patricia C Weber, P. Weber, F. Salemme, 2003, Current opinion in structural biology.

Exploring the role of bromine at C(10) of (+)-4-[2-[4-(8-chloro-3,10-dibromo- 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-2- oxoethyl]-1-piperidinecarboxamide (Sch-66336): the discovery of indolocycloheptapyridine inhibitors of farnesyl protein transferase.

M. Snow, P. Weber, P. Kirschmeier, 2002, Journal of medicinal chemistry.

Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase.

P. Weber, N. Yao, P. Reichert, 1999, Structure.

Structure and assembly of protocatechuate 3,4-dioxygenase

P. C. Weber, P. Weber, D. Ohlendorf, 1988, Nature.

Crystallographic refinement of bovine pro-phospholipase A2 at 1.6 A resolution.

B. Finzel, P. Weber, F. Salemme, 1991, Acta crystallographica. Section B, Structural science.

Binding affinities and geometries of various metal ligands in peptide deformylase inhibitors.

P. Weber, T. Fischmann, A. Cooper, 2002, Biophysical chemistry.

Inactivation of the human cytomegalovirus protease by diisopropylfluorophosphate

P. Weber, B. Dasmahapatra, H. Le, 1997 .

Factors affecting the morphology of isocitrate lyase crystals

P. Weber, R. Feigelson, R. C. DeMattei, 1992 .

Rational design of boropeptide thrombin inhibitors: beta, beta-dialkyl-phenethylglycine P2 analogs of DuP 714 with greater selectivity over complement factor I and an improved safety profile.

P. Weber, R. Knabb, R. Alexander, 1998, Bioorganic & medicinal chemistry letters.

Biaryl substituted alkylboronate esters as thrombin inhibitors

J. Wityak, P. Weber, C. Dominguez, 1997 .

Synthesis of conformationally-restricted boropeptide thrombin inhibitors

D. Brittelli, P. Weber, R. Knabb, 1996 .

Design and synthesis of ring-constrained boropeptide thrombin inhibitors

M. Abelman, D. Brittelli, P. Weber, 1996 .

A non-catalytic role of choline kinase alpha is important in promoting cancer cell survival

P. Weber, P. Charlton, Y. Huang, 2013, Oncogenesis.

(N-acyl-N-alkyl)glycyl borolysine analogs: A new class of potent thrombin inhibitors

M. Abelman, P. Weber, R. Knabb, 1996 .

Emerging targets in the treatment of hepatitis C virus infection

P. Weber, N. Yao, H. Le, 1998 .

Thermodynamic and structural analysis of phosphotyrosine polypeptide binding to Grb2-SH2.

M. Snow, P. Weber, P. Mui, 1997, Biochemistry.

Construction, expression, and characterization of a novel fully activated recombinant single‐chain hepatitis C virus protease

P. Weber, N. Yao, B. Malcolm, 1998, Protein science : a publication of the Protein Society.

Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.

David K Williams, Patricia C Weber, D. Chakrabarti, 2005, Journal of medicinal chemistry.

Crystallographic structure of Rhodospirillum molischianum ferricytochrome c' at 2.5 A resolution.

N. Xuong, P. Weber, F. Salemme, 1981, Journal of molecular biology.

Structure of cytochrome c′: a dimeric, high-spin haem protein

N. Xuong, R. Hamlin, P. Weber, 1980, Nature.

Correlations between structural and spectroscopic properties of the high-spin heme protein cytochrome c'.

P. Weber, 1982, Biochemistry.

On the evolutionary relationship of the 4-alpha-helical heme proteins. The comparison of cytochrome b562 and cytochrome c'.

F. S. Mathews, P. Bethge, P. Weber, 1981, The Journal of biological chemistry.

Microwave‐enhanced enzyme reaction for protein mapping by mass spectrometry: A new approach to protein digestion in minutes

P. Weber, Yan-Hui Liu, B. Pramanik, 2002, Protein science : a publication of the Protein Society.

Pyrazoles, 1,2,4-triazoles, and tetrazoles as surrogates for cis-amide bonds in boronate ester thrombin inhibitors.

P. Weber, R. Knabb, R. Alexander, 1998, Bioorganic & Medicinal Chemistry Letters.

Biophysical tools for structure-based drug design.

M. T. Oliva, J. Wendoloski, P. Weber, 1993, Pharmacology & therapeutics.

STRUCTURE OF SODIUM 4-(4-HYDROXYPHENYLAZO)BENZOATE TETRAHYDRATE

D. M. Simons, P. Weber, R. Harlow, 1992 .

Computational and site‐specific mutagenesis analyses of the asymmetric charge distribution on calmodulin

T. A. Craig, M. King, P. Weber, 1989, Proteins.

Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue.

Zhanghua Wu, P. Weber, L. Beese, 1998, Biochemistry.

Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure-activity relationships.

P. Weber, R. Doll, W. Windsor, 1999, Journal of medicinal chemistry.

Preliminary crystallographic studies on scytalone dehydratase from Magnaporthe grisea.

P. Weber, T. Lundqvist, J. Rice, 1993, Journal of molecular biology.

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

Charles A. Lesburg, P. Weber, Z. Hong, 1999, Nature Structural Biology.

Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB

P. Weber, J. Hunt, J. Benach, 2006, Nature.

Synthesis of 5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidine-N-cyanoguanidine derivatives as inhibitors of ras farnesyl protein transferase.

W. R. Bishop, P. Weber, P. Kirschmeier, 2002, Bioorganic & medicinal chemistry letters.

Crystallization and structural analysis of bullfrog red cell L‐subunit ferritins

Elizabeth C. Theil, N. Allewell, P. Weber, 1994, Proteins.

Structure of the hepatitis C virus RNA helicase domain

A. Kwong, P. Weber, Z. Hong, 1997, Nature Structural Biology.

Synthesis of (5,6‐Dihydro‐11H‐benzo[5,6]cyclohepta [1,2‐b]pyridin‐11‐ylidene)‐1‐piperidine‐N‐cyanoguanidine Derivatives (I) as Inhibitors of Ras Farnesyl Protein Transferase.

W. R. Bishop, P. Weber, P. Kirschmeier, 2002 .

Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice

M. Bouxsein, W. Greenlee, B. Mitlak, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.

Zhuyan Guo, Frank Bennett, Rong-Sheng Yang, 2007, Journal of medicinal chemistry.

Competitor analogs for defined T cell antigens: Peptides incorporating a putative binding motif and polyproline or polyglycine spacers

P. Weber, F. Salemme, J. Maryanski, 1990, Cell.

Molecular dynamics of a cytochrome c-cytochrome b5 electron transfer complex.

J J Wendoloski, F R Salemme, J. Wendoloski, 1987, Science.

Transient kinetics of electron transfer reactions of flavodoxin: ionic strength dependence of semiquinone oxidation by cytochrome c, ferricyanide, and ferric ethylenediaminetetraacetic acid and computer modeling of reaction complexes.

G. Tollin, P. Weber, F. Salemme, 1982, Biochemistry.

Structure-Based Design of Synthetic Azobenzene Ligands for Streptavidin

D. M. Simons, P. Weber, F. Salemme, 1994 .

Electrostatic analysis of the interaction of cytochrome c with native and dimethyl ester heme substituted cytochrome b5.

P. Weber, M. R. Mauk, A. Mauk, 1986, Biochemistry.

Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.

John F Hunt, Diana Wetmore, Spencer Emtage, 2010, Protein engineering, design & selection : PEDS.

Comparisons between the structures of HCV and Rep helicases reveal structural similarities between SF1 and SF2 super‐families of helicases

G. Waksman, P. Weber, T. Lohman, 1998, Protein science : a publication of the Protein Society.

DEAD and DEAH Domains

P. Weber, N. Yao, 2002 .

helicases ofreveal structural similarities between SF 1 and SF 2 superfamilies Comparisons between the structures of HCV and Rep helicases

G. Waksman, P. Weber, T. Lohman, 1997 .

Electrostatic interactions during electron transfer reactions between c-type cytochromes and flavodoxin.

G. Tollin, P. Weber, 1985, The Journal of biological chemistry.

Crystallographic and thermodynamic comparison of natural and synthetic ligands bound to streptavidin

J. J. Wendoloski, J. Wendoloski, P. Weber, 1992 .

Conserved C-Terminal Threonine of Hepatitis C Virus NS3 Regulates Autoproteolysis and Prevents Product Inhibition

S. Lemon, P. Weber, B. Malcolm, 2004, Journal of Virology.

The 2-A resolution structure of a thermostable ribonuclease A chemically cross-linked between lysine residues 7 and 41.

B. Finzel, P. Weber, F. Salemme, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Molecular Recognition of Cyclic Urea HIV-1 Protease Inhibitors*

Chong-Hwan Chang, PatrickY.-S. Lam, P. Jadhav, 1998, The Journal of Biological Chemistry.

Recent results and new hardware developments for protein crystal growth in microgravity

A. D. Clark, A. Sacco, K. Moore, 1994 .

Protein crystal growth results for shuttle flights STS-26 and STS-29

G. S. Nelson, L. DeLucas, D. Stammers, 1991 .

Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs.

P. Weber, S. L. Lee, C. Kettner, 1995, Biochemistry.

Electrostatic orientation during electron transfer between flavodoxin and cytochrome c

F. Richards, P. Weber, F. Salemme, 1983, Nature.

Systematic investigation of crystallization parameters for protein-nucleic acid complexes: application to an active truncated form ofEscherichia coli topoisomerase I

P. Weber, Y. Tse‐Dinh, Chang-Xi Zhu, 1992 .

Physical principles of protein crystallization.

P. Weber, P C Weber, Patricia C. Weber, 1991, Advances in protein chemistry.

An investigation of protein crystallization parameters using successive automated grid searches (SAGS)

P. Weber, M. Jane Cox, Patricia C. Weber, 1988 .

Crystallographic data for Streptomyces avidinii streptavidin.

P. Weber, F. Salemme, D. Ohlendorf, 1987, The Journal of biological chemistry.

Biochemical and crystallographic characterization of homologous non-peptidic thrombin inhibitors having alternate binding modes.

P. Weber, C. Kettner, C. Strickland, 1998, Acta crystallographica. Section D, Biological crystallography.

Crystallographic and thermodynamic comparison of structurally diverse molecules binding to streptavidin.

P. Weber, F. Salemme, M. Pantoliano, 1995, Acta crystallographica. Section D, Biological crystallography.

Serine protease of hepatitis C virus expressed in insect cells as the NS3/4A complex.

A. Kwong, P. Weber, Z. Hong, 1998, Biochemistry.

[2] Overview of protein crystallization methods.

Patricia C Weber, P. Weber, 1997, Methods in enzymology.

Mechanism of autoproteolysis at the NS2-NS3 junction of the hepatitis C virus polyprotein.

P. Weber, N. Yao, H. Le, 1998, Trends in biochemical sciences.

Helicase, a target for novel inhibitors of hepatitis C virus.

P. Weber, N. Yao, 1998, Antiviral therapy.

Faculty Opinions recommendation of Extended polyglutamine tracts cause aggregation and structural perturbation of an adjacent beta barrel protein.

P. Weber, 2006 .

Protein crystal growth aboard the U.S. space shuttle flights STS-31 and STS-32.

L. DeLucas, L. Prasad, L. Delbaere, 1992, Advances in space research : the official journal of the Committee on Space Research.

Determination of the quaternary structure of protocatechuate 3,4-dioxygenase from Pseudomonas aeruginosa.

P. Weber, D. Ohlendorf, J. Lipscomb, 1987, Journal of Molecular Biology.

Crystal structure and ligand-binding studies of a screened peptide complexed with streptavidin.

P. Weber, M. Pantoliano, P C Weber, 1992, Biochemistry.

Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models

J. Paulo, L. Stephens, P. Weber, 2023, Journal of Clinical Investigation.

Faculty Opinions recommendation of Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition.

P. Weber, 2003 .

Cooperative ligand reorientations in cytochrome c3: a molecular dynamics simulation.

J. Wendoloski, P. Weber, F. Salemme, 1991, Biochimica et biophysica acta.

Molecular Switching Transitions In Biological Macromolecules

J. Wendoloski, P. Weber, F. Salemme, 1990, [1990] Proceedings of the Twelfth Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

Carbon monoxide binding to Rhodospirillum molischianum ferrocytochrome c'.

M. Doyle, P. Weber, S. Gill, 1985, Biochemistry.

Preliminary crystallographic data for cytochromes c' of Rhodopseudomonas capsulata and Rhodospirillum molischianum.

P. Weber, F. Salemme, 1977, Journal of molecular biology.

Crystallization of resolvase, a repressor that also catalyzes site-specific DNA recombination.

T. Steitz, D. Ollis, P. Weber, 1982, Journal of molecular biology.

Faculty Opinions recommendation of Structural basis of transcription initiation: an RNA polymerase holoenzyme-DNA complex.

P. Weber, 2002 .

Computational and database retrieval approaches for determining polypeptide conformation

Francis Raymond Salemme, Z. R. Wasserman, P. C. Weber, 1991 .