M. Akabas

发表

Substituted-cysteine accessibility method.

A. Karlin, M. Akabas, 1998, Methods in enzymology.

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the α subunit

A. Karlin, M. Akabas, C. Kaufmann, 1994, Neuron.

Emerging molecular mechanisms of general anesthetic action.

B. Orser, J. Trudell, M. Akabas, 2005, Trends in pharmacological sciences.

Structural Evidence that Propofol Stabilizes Different GABAA Receptor States at Potentiating and Activating Concentrations

M. Akabas, Myles H Akabas, Daniel B. Williams, 2002, The Journal of Neuroscience.

Taking Charge: Feeding Malaria via Anion Channels

D. Fidock, M. Akabas, E. Ekland, 2011, Cell.

Purine import into malaria parasites as a target for antimalarial drug development

M. Akabas, I. J. Frame, R. Deniskin, 2015, Annals of the New York Academy of Sciences.

Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction.

M. Akabas, D. C. Cabelof, L. Matherly, 2007, American journal of physiology. Cell physiology.

The Proton-Coupled Folate Transporter: Impact on Pemetrexed Transport and on Antifolates Activities Compared with the Reduced Folate Carrier

M. Akabas, I. Goldman, M. Jansen, 2008, Molecular Pharmacology.

5-HT3 receptor ion size selectivity is a property of the transmembrane channel, not the cytoplasmic vestibule portals

M. Akabas, Nicole K. McKinnon, D. Reeves, 2011, The Journal of general physiology.

Na+/Ca2+ Exchange Inhibitors: Potential Drugs to Mitigate the Severity of Ischemic Injury

M. Akabas, 2004, Molecular Pharmacology.

Na+/Ca2+ exchange inhibitors: potential drugs to mitigate the severity of ischemic injury.

M. Akabas, 2004, Molecular pharmacology.

Chloride Channels

M. Akabas, 2020, eLS.

Are MD-PhD Programs Meeting Their Goals? An Analysis of Career Choices Made by Graduates of 24 MD-PhD Programs

M. Akabas, D. Engman, Lawrence F Brass, 2010, Academic medicine : journal of the Association of American Medical Colleges.

History and Outcomes of 50 Years of Physician-Scientist Training in Medical Scientist Training Programs.

M. Akabas, C. Harding, Olaf S Andersen, 2017, Academic medicine : journal of the Association of American Medical Colleges.

Separation of the osmotically driven fusion event from vesicle-planar membrane attachment in a model system for exocytosis

M. Akabas, A. Finkelstein, F. S. Cohen, 1984, The Journal of cell biology.

Mater Artium Necessitas: The Birth of a COVID-19 Command Center

M. Prystowsky, M. Akabas, D. Goldstein, 2021, Academic Pathology.

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Manuel Llinás, George Papadatos, Sundari Suresh, 2016, PLoS pathogens.

Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site.

M. Akabas, M. Jansen, Axelle Strehle, 2008, Journal of medicinal chemistry.

Osmotic swelling of phospholipid vesicles causes them to fuse with a planar phospholipid bilayer membrane.

M. Akabas, A. Finkelstein, F. S. Cohen, 1982, Science.

Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms.

P. Roepe, D. Fidock, M. Akabas, 2006, Molecular and biochemical parasitology.

Identification of an Intestinal Folate Transporter and the Molecular Basis for Hereditary Folate Malabsorption

M. Akabas, I. Goldman, M. Jansen, 2006, Cell.

Mechanisms of chemosensory transduction in taste cells.

M. Akabas, 1990, International review of neurobiology.

Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1.

V. Schramm, Richard F. G. Fröhlich, M. Cassera, 2010, Molecular and biochemical parasitology.

Parameters affecting the fusion of unilamellar phospholipid vesicles with planar bilayer membranes

F S Cohen, M. Akabas, J. Zimmerberg, 1984, The Journal of cell biology.

A bitter substance induces a rise in intracellular calcium in a subpopulation of rat taste cells.

M. Akabas, Q. Al-Awqati, J. Dodd, 1988, Science.

Probing the Structural and Functional Domains of the CFTR Chloride Channel

M. Akabas, R. Guinamard, M. Cheung, 1997, Journal of bioenergetics and biomembranes.

Length and Amino Acid Sequence of Peptides Substituted for the 5-HT3A Receptor M3M4 Loop May Affect Channel Expression and Desensitization

M. Akabas, M. Bali, N. McKinnon, 2012, PloS one.

Modular Design of Cys-loop Ligand-gated Ion Channels: Functional 5-HT3 and GABA ρ1 Receptors Lacking the Large Cytoplasmic M3M4 Loop

M. Akabas, M. Jansen, M. Bali, 2008, The Journal of general physiology.

Structural and Electrostatic Properties of the 5-HT3Receptor Pore Revealed by Substituted Cysteine Accessibility Mutagenesis*

M. Akabas, S. C. Lummis, D. Reeves, 2001, The Journal of Biological Chemistry.

Gating-induced Conformational Rearrangement of the γ-Aminobutyric Acid Type A Receptor β-α Subunit Interface in the Membrane-spanning Domain*

M. Akabas, M. Bali, 2012, The Journal of Biological Chemistry.

State-Dependent Cross-Linking of the M2 and M3 Segments: Functional Basis for the Alignment of GABAA and Acetylcholine Receptor M3 Segments

M. Akabas, M. Jansen, 2006, The Journal of Neuroscience.

Molecular State-Dependent Cross-Linking of the M 2 and M 3 Segments : Functional Basis for the Alignment of GABAA and Acetylcholine Receptor M 3 Segments

M. Akabas, M. Jansen, 2006 .

Differential Protein Mobility of the γ-Aminobutyric Acid, Type A, Receptor α and β Subunit Channel-lining Segments*

M. Akabas, P. Riegelhaupt, J. Horenstein, 2005, Journal of Biological Chemistry.

Protein mobility and GABA-induced conformational changes in GABAA receptor pore-lining M2 segment

M. Akabas, C. Czajkowski, D. Wagner, 2001, Nature Neuroscience.

Amino acids lining the channel of the gamma-aminobutyric acid type A receptor identified by cysteine substitution.

M. Akabas, M. Xu, 1993, The Journal of biological chemistry.

Defining the propofol binding site location on the GABAA receptor.

M. Akabas, Moez Bali, Myles H Akabas, 2004, Molecular pharmacology.

Channel-lining residues in the M3 membrane-spanning segment of the cystic fibrosis transmembrane conductance regulator.

M. Akabas, 1998, Biochemistry.

Locating the Anion-selectivity Filter of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel

M. Akabas, M. Cheung, Min Cheung, 1997, The Journal of general physiology.

Identification of cystic fibrosis transmembrane conductance regulator channel-lining residues in and flanking the M6 membrane-spanning segment.

M. Akabas, M. Cheung, Min Cheung, 1996, Biophysical journal.

Amino acid residues lining the chloride channel of the cystic fibrosis transmembrane conductance regulator.

M. Akabas, C. Kaufmann, P. Archdeacon, 1994, The Journal of biological chemistry.

Identification of electrophysiologically distinct subpopulations of rat taste cells

J. Dodd, M. Akabas, Q. Al-Awqati, 1990, The Journal of Membrane Biology.

Erythrocytic Adenosine Monophosphate as an Alternative Purine Source in Plasmodium falciparum*

V. Schramm, M. Cassera, E. F. Merino, 2008, Journal of Biological Chemistry.

Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins

A. Karlin, M. Akabas, 1995, Neuron.

Malaria parasite type 4 equilibrative nucleoside transporters (ENT4) are purine transporters with distinct substrate specificity.

V. Schramm, M. Cassera, E. F. Merino, 2012, The Biochemical journal.

Targeting the Plasmodium vivax equilibrative nucleoside transporter 1 (PvENT1) for antimalarial drug development

M. Akabas, I. J. Frame, R. Deniskin, 2015, International journal for parasitology. Drugs and drug resistance.

Yeast-based high-throughput screen identifies Plasmodium falciparum equilibrative nucleoside transporter 1 inhibitors that kill malaria parasites.

D. Fidock, M. Akabas, D. Landry, 2015, ACS chemical biology.

Cysteine Modification: Probing Channel Structure, Function and Conformational Change.

M. Akabas, 2015, Advances in experimental medicine and biology.

Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants.

M. Akabas, D. Covey, M. Xu, 1995, Biophysical journal.

Acetylcholine receptor channel structure probed in cysteine-substitution mutants.

A. Karlin, M. Akabas, Ming Xu, 1992, Science.

GABA-Induced Intersubunit Conformational Movement in the GABAA Receptor α1M1-β2M3 Transmembrane Subunit Interface: Experimental Basis for Homology Modeling of an Intravenous Anesthetic Binding Site

M. Akabas, M. Jansen, M. Bali, 2009, The Journal of Neuroscience.

GABAA receptor structure-function studies: a reexamination in light of new acetylcholine receptor structures.

M. Akabas, 2004, International review of neurobiology.

The national MD-PhD program outcomes study: Relationships between medical specialty, training duration, research effort, and career paths.

M. Akabas, L. Brass, 2019, JCI insight.

Gaps between college and starting an MD-PhD program are adding years to physician-scientist training time

R. Fitzsimonds, M. Akabas, Lawrence F Brass, 2022, JCI insight.

The national MD-PhD program outcomes study: Outcomes variation by sex, race, and ethnicity.

M. Akabas, L. Brass, 2019, JCI insight.

MD‐PhD graduates remain underrepresented in orthopaedic surgery: National MD‐PhD Program Outcome Survey update

M. Akabas, D. Amanatullah, L. Brass, 2020, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Pearls of wisdom for aspiring physician-scientist residency applicants and program directors

D. Rockey, P. Conlin, M. Akabas, 2022, JCI insight.

A closer look at attrition in MD-PhD programs.

M. Akabas, L. Brass, 2014, Academic medicine : journal of the Association of American Medical Colleges.

Probing the multifactorial basis of Plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE.

D. Fidock, T. Wellems, M. Akabas, 2009, Molecular and biochemical parasitology.

Using molecular dynamics to elucidate the structural basis for function in pLGICs

M. Akabas, 2013, Proceedings of the National Academy of Sciences.

Cystic Fibrosis Transmembrane Conductance Regulator

M. Akabas, 2000, The Journal of Biological Chemistry.

Exposure of Residues in the Cyclic Nucleotide–Gated Channel Pore: P Region Structure and Function in Gating

S. Siegelbaum, A. Karlin, M. Akabas, 1996, Neuron.

Parallel Hit Progression Strategy Identifies Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Proliferation.

Deepak Bandyopadhyay, M. Akabas, T. Graybill, 2019, ACS infectious diseases.

Benzodiazepines Induce a Conformational Change in the Region of the γ-Aminobutyric Acid Type A Receptor α1-Subunit M3 Membrane-Spanning Segment

M. Akabas, Daniel B. Williams, 2000 .

Probing CFTR channel structure and function using the substituted-cysteine-accessibility method.

M. Akabas, 2002, Methods in molecular medicine.

Transmembrane Segment 11 Appears to Line the Purine Permeation Pathway of the Plasmodium falciparum Equilibrative Nucleoside Transporter 1 (PfENT1)*

M. Akabas, P. Riegelhaupt, I. J. Frame, 2010, The Journal of Biological Chemistry.

UV-triggered Affinity Capture Identifies Interactions between the Plasmodium falciparum Multidrug Resistance Protein 1 (PfMDR1) and Antimalarial Agents in Live Parasitized Cells*

P. Roepe, D. Fidock, M. Akabas, 2013, The Journal of Biological Chemistry.

Drosophila Pacemaker Neurons Require G Protein Signaling and GABAergic Inputs to Generate Twenty-Four Hour Behavioral Rhythms

M. Akabas, J. Blau, M. Ruben, 2010, Neuron.

The Location of a Closed Channel Gate in the GABAA Receptor Channel

M. Akabas, M. Bali, 2007, The Journal of general physiology.

γ-Aminobutyric Acid Increases the Water Accessibility of M3 Membrane-Spanning Segment Residues in γ-Aminobutyric Acid Type A Receptors

M. Akabas, Daniel B. Williams, 1999 .

Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit

M. Akabas, M. Xu, 1996, The Journal of general physiology.

Balance of Activity between LNvs and Glutamatergic Dorsal Clock Neurons Promotes Robust Circadian Rhythms in Drosophila

M. Akabas, J. Blau, B. Collins, 2012, Neuron.

16 – Purification and Reconstitution of the Epithelial Chloride Channel

M. Akabas, Q. Al-Awqati, D. Landry, 1989 .

Substrate and Inhibitor Specificity of the Plasmodium berghei Equilibrative Nucleoside Transporter Type 1

D. Fidock, M. Akabas, Sita Nirupama Nishtala, 2016, Molecular Pharmacology.

Balance of Activity between LNvs and Glutamatergic Dorsal Clock Neurons Promotes Robust Circadian Rhythms in Drosophila

Elizabeth A. Kane, M. Akabas, J. Blau, 2012, Neuron.

Receptor Channels in Rat Hippocampal Interneurons 3 Ions Block and Permeate Serotonin 5-HT

M. Rozložník, W. Wadman, M. Akabas, 2015 .

Evidence for distinct conformations of the two α1 subunits in diazepam-bound GABAA receptors

M. Akabas, Daniel B. Williams, 2001, Neuropharmacology.

Functional and Structural Analysis of the GABAA Receptor α1 Subunit during Channel Gating and Alcohol Modulation*

M. Akabas, R. Harris, Sangwook Jung, 2005, Journal of Biological Chemistry.

Location of a high affinity Zn2+ binding site in the channel of alpha1beta1 gamma-aminobutyric acidA receptors.

M. Akabas, J. Horenstein, 1998, Molecular pharmacology.

Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptors.

M. Akabas, D. B. Williams, 1999, Biophysical journal.

A Role for the β1-β2 Loop in the Gating of 5-HT3 Receptors

M. Akabas, M. Jansen, T. Lemster, 2005, The Journal of Neuroscience.

GABAA Receptor M2–M3 Loop Secondary Structure and Changes in Accessibility during Channel Gating*

M. Akabas, A. Bera, Maya Chatav, 2002, The Journal of Biological Chemistry.

Accessibility of substituted cysteines in TM2 and TM10 transmembrane segments in the Plasmodium falciparum equilibrative nucleoside transporter PfENT1

M. Akabas, Sita Nirupama Nishtala, Avish Arora, 2018, The Journal of Biological Chemistry.

Channels: Rotamers affect ion conductance.

M. Akabas, 2012, Nature chemical biology.

Structure of the M2 Transmembrane Segment of GLIC, a Prokaryotic Cys Loop Receptor Homologue from Gloeobacter violaceus, Probed by Substituted Cysteine Accessibility*

M. Akabas, Rishi B. Parikh, M. Bali, 2011, The Journal of Biological Chemistry.

Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment.

M. Akabas, J. Horenstein, M. Bali, 2007, Biophysical journal.

Watching single protons bind

M. Akabas, 2006, Nature chemical biology.

GABAA receptor interactions with propofol: Binding site location and conformational changes

M. Akabas, M. Bali, 2005 .

Loose Protein Packing around the Extracellular Half of the GABAA Receptor β1 Subunit M2 Channel-lining Segment*

M. Akabas, D. Reeves, E. N. Goren, 2004, Journal of Biological Chemistry.

Fusion of phospholipid vesicles with a planar membrane depends on the membrane permeability of the solute used to create the osmotic pressure

M. Akabas, F. S. Cohen, W. Niles, 1989, The Journal of general physiology.

Impact of field isolate identified non-synonymous single nucleotide polymorphisms on Plasmodium falciparum Equilibrative Nucleoside Transporter 1 (PfENT1) inhibitor efficacy.

M. Akabas, Y. Sosa, Deborah Egbo, 2019, ACS infectious diseases.

Identification of acetylcholine receptor channel-lining residues in the M1 segment of the alpha-subunit.

A. Karlin, M. Akabas, 1995, Biochemistry.

Are epsins a therapeutic target for tumor

B. Orser, M. Akabas, H. Hemmings, 2012 .

Evidence for distinct conformations of the two alpha 1 subunits in diazepam-bound GABA(A) receptors.

M. Akabas, D. B. Williams, 2001, Neuropharmacology.

Benzodiazepines induce a conformational change in the region of the gamma-aminobutyric acid type A receptor alpha(1)-subunit M3 membrane-spanning segment.

M. Akabas, D. B. Williams, 2000, Molecular pharmacology.

Spontaneous Thermal Motion of the GABAA Receptor M2 Channel-lining Segments*

M. Akabas, A. Bera, 2005, Journal of Biological Chemistry.

Purification and reconstitution of chloride channels from kidney and trachea

M. Akabas, Q. Al-Awqati, A. Edelman, 1989, Science.

Parallel Hit Progression Strategy Identifies Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Proliferation

M. Akabas, T. Graybill, K. Widdowson, 2020 .

Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1.

V. Schramm, Richard F. G. Fröhlich, M. Cassera, 2010, Molecular and biochemical parasitology.

Purine import into malaria parasites as a target for antimalarial drug development

M. Akabas, I. J. Frame, R. Deniskin, 2015, Annals of the New York Academy of Sciences.

Separation of the Osmotically Driven Fusion Event from Vesicle-planar Membrane Attachment in a Model System for Exocytosis Materials and Methods

M. Akabas, Fredric S. Cohen, Alan Finkelstein, 2022 .

Putative purine nucleoside interacting residues in the malaria parasite purine uptake transporter PfENT1 are critical for transporter function

M. Akabas, Criselda Dillague, 2023, PloS one.

Fusion of phospholipid vesicles with a planar membrane depends on the membrane permeability of the solute used to create the osmotic pressure

M. Akabas, Walter D. Niles, Fredric S. Cohen, 1989, The Journal of General Physiology.

The Role of Calcium and Osmosis in Membrane Fusion

M. Akabas, A. Finkelstein, F. S. Cohen, 1985 .