D. C. Chiara

发表

Identification of nicotinic acetylcholine receptor amino acids photolabeled by the volatile anesthetic halothane.

R. Eckenhoff, D. C. Chiara, L. Dangott, 2003, Biochemistry.

Active-site peptides of acetylcholinesterase of Electrophorus electricus: labelling of His-440 by 1-bromo-[2-14C]pinacolone and Ser-200 by tritiated diisopropyl fluorophosphate.

J. B. Cohen, D. C. Chiara, E. Salih, 1994, Biochimica et biophysica acta.

Anesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptors

D. C. Chiara, K. Miller, S. Forman, 2015, Neuropharmacology.

Identification of the bovine gamma-aminobutyric acid type A receptor alpha subunit residues photolabeled by the imidazobenzodiazepine [3H]Ro15-4513.

R. Olsen, D. C. Chiara, Jonathan B. Cohen, 2002, The Journal of biological chemistry.

Multiple Propofol-binding Sites in a γ-Aminobutyric Acid Type A Receptor (GABAAR) Identified Using a Photoreactive Propofol Analog*♦

R. Eckenhoff, D. C. Chiara, Jonathan B. Cohen, 2014, The Journal of Biological Chemistry.

Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABAA) receptors

D. C. Chiara, Jonathan B. Cohen, K. Miller, 2020, The Journal of Biological Chemistry.

A-Aminobutyric Acid Type A ( GABA γ Inhibit Etomidate Binding to Numerous Classes of General Anesthetics Protein Structure and Folding :

R. Olsen, D. C. Chiara, Jonathan B. Cohen, 2010 .

Unraveling amino acid residues critical for allosteric potentiation of ( (cid:2) 4)3( (cid:3) 2)2-type nicotinic acetylcholine receptor responses

D. C. Chiara, F. Deba, Ayman K. Hamouda, 2020 .

Unraveling amino acid residues critical for allosteric potentiation of (α4)3(β2)2-type nicotinic acetylcholine receptor responses

D. C. Chiara, Ze-Jun Wang, F. Deba, 2017, The Journal of Biological Chemistry.

Probing the structure of the affinity-purified and lipid-reconstituted torpedo nicotinic acetylcholine receptor.

M. P. Blanton, D. C. Chiara, Jonathan B. Cohen, 2008, Biochemistry.

Identification of tryptophan 55 as the primary site of [3H]nicotine photoincorporation in the γ‐subunit of the Torpedo nicotinic acetylcholine receptor

J. B. Cohen, D. C. Chiara, Jonathan B. Cohen, 1998, FEBS letters.

General Anesthetic Binding Sites in Human (cid:2) 4 (cid:3) 3 (cid:4) (cid:5) -Aminobutyric Acid Type A Receptors (GABA A Rs) *

D. C. Chiara, Jonathan B. Cohen, K. Miller, 2020 .

[3H]Benzophenone photolabeling identifies state-dependent changes in nicotinic acetylcholine receptor structure.

D. C. Chiara, Jonathan B. Cohen, S. Nirthanan, 2007, Biochemistry.

Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.

D. Raines, D. C. Chiara, Jonathan B. Cohen, 2012, Journal of medicinal chemistry.

Gating-enhanced Accessibility of Hydrophobic Sites within the Transmembrane Region of the Nicotinic Acetylcholine Receptor's δ-Subunit

D. C. Chiara, Jonathan B. Cohen, K. Miller, 2005, Journal of Biological Chemistry.

α‐Conotoxin GI benzoylphenylalanine derivatives

V. S. Pashkov, D. C. Chiara, Jonathan B. Cohen, 2006 .

Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands.

D. C. Chiara, Jonathan B. Cohen, K. Miller, 2017, European journal of medicinal chemistry.

Cysteine Substitutions Define Etomidate Binding and Gating Linkages in the α-M1 Domain of γ-Aminobutyric Acid Type A (GABAA) Receptors*

R. Olsen, D. C. Chiara, S. Forman, 2013, The Journal of Biological Chemistry.

Numerous Classes of General Anesthetics Inhibit Etomidate Binding to γ-Aminobutyric Acid Type A (GABAA) Receptors*

R. Olsen, D. C. Chiara, Jonathan B. Cohen, 2010, The Journal of Biological Chemistry.

Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β− Interface*

D. C. Chiara, Jonathan B. Cohen, K. Miller, 2015, The Journal of Biological Chemistry.

A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor

D. C. Chiara, Jonathan B. Cohen, K. Bruzik, 2019, The Journal of Biological Chemistry.

Identifying the lipid-protein interface of the alpha4beta2 neuronal nicotinic acetylcholine receptor: hydrophobic photolabeling studies with 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine.

M. P. Blanton, D. C. Chiara, Jonathan B. Cohen, 2007, Biochemistry.

Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors.

D. C. Chiara, Jonathan B. Cohen, K. Miller, 2019, European journal of medicinal chemistry.

Identification of a GABAA Receptor Anesthetic Binding Site at Subunit Interfaces by Photolabeling with an Etomidate Analog

R. Olsen, D. C. Chiara, Jonathan B. Cohen, 2006, The Journal of Neuroscience.

Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the α1β3γ2 GABAAR Transmembrane Domain

D. C. Chiara, Jonathan B. Cohen, K. Miller, 2019, Molecular Pharmacology.

Specificity of Intersubunit General Anesthetic-binding Sites in the Transmembrane Domain of the Human α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor*♦

D. C. Chiara, Jonathan B. Cohen, K. Miller, 2013, The Journal of Biological Chemistry.

Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue.

D. C. Chiara, Jonathan B. Cohen, K. Miller, 2012, Biochemistry.

General Anesthetic Binding Sites in Human α4β3δ γ-Aminobutyric Acid Type A Receptors (GABAARs)*

D. C. Chiara, Jonathan B. Cohen, K. Miller, 2016, The Journal of Biological Chemistry.

Identification of Amino Acids Contributing to High and Low Affinity d-Tubocurarine Sites in the TorpedoNicotinic Acetylcholine Receptor*

D. C. Chiara, Jonathan B. Cohen, 1997, The Journal of Biological Chemistry.

[(3)H]chlorpromazine photolabeling of the torpedo nicotinic acetylcholine receptor identifies two state-dependent binding sites in the ion channel.

D. C. Chiara, Jonathan B. Cohen, M. Ziebell, 2009, Biochemistry.

Photoreactive Propofol Analog R ) Identified Using aA ( GABA-Aminobutyric Acid Type A Receptor γ Multiple Propofol-binding Sites in a Neurobiology :

R. Eckenhoff, D. C. Chiara, Jonathan B. Cohen, 2014 .

p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol.

D. Raines, D. C. Chiara, Jonathan B. Cohen, 2011, Journal of medicinal chemistry.

Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol

J. Steinbach, D. C. Chiara, Jonathan B. Cohen, 2016, Current neuropharmacology.

Mapping the agonist binding site of the nicotinic acetylcholine receptor by cysteine scanning mutagenesis: antagonist footprint and secondary structure prediction.

D. C. Chiara, Jonathan B. Cohen, Deirdre Sullivan, 2002, Molecular pharmacology.

Identification of the Bovine γ-Aminobutyric Acid Type A Receptor α Subunit Residues Photolabeled by the Imidazobenzodiazepine [3H]Ro15-4513*

R. Olsen, D. C. Chiara, Jonathan B. Cohen, 2002, The Journal of Biological Chemistry.

Probing the Structure of the Nicotinic Acetylcholine Receptor with 4-Benzoylbenzoylcholine, a Novel Photoaffinity Competitive Antagonist*

D. C. Chiara, Jonathan B. Cohen, Dong Wang, 2000, The Journal of Biological Chemistry.

Structure of the agonist-binding sites of the Torpedo nicotinic acetylcholine receptor: affinity-labeling and mutational analyses identify gamma Tyr-111/delta Arg-113 as antagonist affinity determinants.

D. C. Chiara, J. Cohen, Y. Xie, 1999, Biochemistry.

Identification of Binding Sites in the Nicotinic Acetylcholine Receptor for TDBzl-etomidate, a Photoreactive Positive Allosteric Effector*

D. C. Chiara, Jonathan B. Cohen, S. Husain, 2008, Journal of Biological Chemistry.

Conformational changes in the nicotinic acetylcholine receptor during gating and desensitization.

D. C. Chiara, Jonathan B. Cohen, K. Miller, 2010, Biochemistry.

Photoaffinity Labeling of Nicotinic Receptors: Diversity of Drug Binding Sites!

D. C. Chiara, Jonathan B. Cohen, S. Jayakar, 2014, Journal of Molecular Neuroscience.

Photoaffinity Labeling of Pentameric Ligand-Gated Ion Channels: A Proteomic Approach to Identify Allosteric Modulator Binding Sites.

D. C. Chiara, S. Jayakar, Ayman K. Hamouda, 2017, Methods in molecular biology.

Photoaffinity labeling the propofol binding site in GLIC.

R. Eckenhoff, D. C. Chiara, Jonathan B. Cohen, 2013, Biochemistry.

Neurosteroids Allosterically Modulate Binding of the Anesthetic Etomidate to γ-Aminobutyric Acid Type A Receptors*

R. Olsen, D. C. Chiara, Jonathan B. Cohen, 2009, Journal of Biological Chemistry.

Time-Resolved Photolabeling of the Nicotinic Acetylcholine Receptor by [3H]Azietomidate, an Open-State Inhibitor

D. C. Chiara, Jonathan B. Cohen, S. Husain, 2009, Molecular Pharmacology.

Cholesterol interacts with transmembrane alpha-helices M1, M3, and M4 of the Torpedo nicotinic acetylcholine receptor: photolabeling studies using [3H]Azicholesterol.

M. P. Blanton, D. C. Chiara, Jonathan B. Cohen, 2006, Biochemistry.

Interactions between 3-(Trifluoromethyl)-3-(m-[(125)I]iodophenyl)diazirine and tetracaine, phencyclidine, or histrionicotoxin in the Torpedo series nicotinic acetylcholine receptor ion channel.

D. C. Chiara, M. Gallagher, J. Cohen, 2001, Molecular pharmacology.

Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β− Interface*

D. C. Chiara, Jonathan B. Cohen, K. Miller, 2015, The Journal of Biological Chemistry.

[(3)H]chlorpromazine photolabeling of the torpedo nicotinic acetylcholine receptor identifies two state-dependent binding sites in the ion channel.

D. C. Chiara, Jonathan B. Cohen, M. Ziebell, 2009, Biochemistry.

Photoaffinity labeling the propofol binding site in GLIC.

R. Eckenhoff, D. C. Chiara, Jonathan B. Cohen, 2014, Biochemistry.