A. Orian

发表

Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network.

B. Edgar, H. Bussemaker, J. Delrow, 2003, Genes & development.

Drosophila COP9 signalosome subunit 7 interacts with multiple genomic loci to regulate development

Daniel A. Chamovitz, Tamir Tuller, Shimshi Atar, 2014, Nucleic acids research.

Chromatin profiling, DamID and the emerging landscape of gene expression.

A. Orian, Amir Orian, 2006, Current opinion in genetics & development.

Ubiquitin‐mediated proteolysis: biological regulation via destruction

A. Ciechanover, A. Orian, A. Schwartz, 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.

Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells

A. Orian, M. Eilers, C. Münch, 2020, EMBO molecular medicine.

The USP28-ΔNp63 axis is a vulnerability of squamous tumours

A. Orian, M. Eilers, M. Calzado, 2019, bioRxiv.

Ubiquitin-mediated Processing of NF-κB Transcriptional Activator Precursor p105

A. Ciechanover, A. Israël, A. Orian, 1995, The Journal of Biological Chemistry.

The Biology of SUMO-Targeted Ubiquitin Ligases in Drosophila Development, Immunity, and Cancer

A. Orian, M. Abed, Eliya Bitman-Lotan, 2018, Journal of developmental biology.

Isoform‐Specific SCFFbw7 Ubiquitination Mediates Differential Regulation of PGC‐1α

A. Orian, A. Schwartz, J. Trausch-Azar, 2015, Journal of cellular physiology.

Hyd ubiquitinates the NF-κB co-factor Akirin to operate an effective immune response in Drosophila

M. Boutros, A. Orian, X. Nguyen, 2020, PLoS pathogens.

The ubiquitin-mediated proteolytic system: involvement of molecular chaperones, degradation of oncoproteins, and activation of transcriptional regulators.

A. Ciechanover, A. Orian, B. Bercovich, 1995, Cold Spring Harbor symposia on quantitative biology.

Mechanisms of ubiquitin-mediated, limited processing of the NF-kappaB1 precursor protein p105.

A. Ciechanover, A. Israël, A. Orian, 2001, Biochimie.

Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5−/− mice

E. Ruppin, S. Yooseph, K. Brown, 2019, Nature Communications.

Stabilization of nuclear oncoproteins by RNF4 and the ubiquitin system in cancer

A. Orian, M. Diefenbacher, 2017, Molecular & cellular oncology.

RNF4-Dependent Oncogene Activation by Protein Stabilization

W. Birchmeier, G. Dittmar, A. Orian, 2016, Cell reports.

RNF 4-Dependent Oncogen e Activation by Protein Stabilization Graphical Abstract Highlights

W. Birchmeier, G. Dittmar, A. Orian, 2016 .

Phosphorylation of Groucho Mediates RTK Feedback Inhibition and Prolonged Pathway Target Gene Expression

Z. Paroush, G. Jiménez, A. Orian, 2011, Current Biology.

SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation

Jian Zhang, Xinyi Liu, A. Orian, 2015, Protein & Cell.

A fly view of a SUMO-targeted ubiquitin ligase

A. Orian, M. Abed, Eliya Bitman-Lotan, 2011, Fly.

Ubiquitination Domain Glycine-Rich Region and a Downstream B Precursor p 105 : Roles of the κ Ubiquitin-Mediated Processing of the NF-Structural Motifs Involved in

A. Ciechanover, A. Israël, A. Orian, 1999 .

Supplemental Information RNF 4-Dependent Oncogene Activation by Protein Stabilization

W. Birchmeier, A. Orian, A. Schwartz, 2016 .

Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development

B. Edgar, R. Eisenman, A. Orian, 2005, Nature Cell Biology.

RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival

A. Orian, Y. Shaked, M. Diefenbacher, 2022, Cell Death & Disease.

From the Evasion of Degradation to Ubiquitin-Dependent Protein Stabilization

A. Orian, Eliya Bitman-Lotan, Avital Oknin-Vaisman, 2021, Cells.

Regulation of eIF2α by RNF4 promotes melanoma tumorigenesis and therapy resistance.

E. Ruppin, K. Brown, J. Lee, 2020, The Journal of investigative dermatology.

The transcription factor Hey and nuclear lamins specify and maintain cell identity

A. Orian, M. Monastirioti, Héctor Rincón-Arano, 2019, eLife.

The SUMO-targeted ubiquitin ligase, Dgrn, is essential for Drosophila innate immunity.

A. Orian, J. Reichhart, B. Koltun, 2017, The International journal of developmental biology.

The Drosophila STUbL protein Degringolade limits HES functions during embryogenesis

A. Orian, S. Parkhurst, M. Abed, 2011, Development.

Degringolade, a SUMO‐targeted ubiquitin ligase, inhibits Hairy/Groucho‐mediated repression

J. Delrow, A. Orian, S. Parkhurst, 2011, The EMBO journal.

Identification of the Ubiquitin Carrier Proteins, E2s, Involved in Signal-induced Conjugation and Subsequent Degradation of IκBα*

Andrea C. Carrano, A. Ciechanover, M. Pagano, 1999, The Journal of Biological Chemistry.

Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes

R. Eisenman, A. Orian, S. Cowley, 2002, Proceedings of the National Academy of Sciences of the United States of America.

TGF-β Flips the Myc Switch

R. Eisenman, A. Orian, 2001, Science's STKE.

Genomic binding and transcriptional regulation by the Drosophila Myc and Mnt transcription factors.

B. Edgar, R. Eisenman, A. Orian, 2005, Cold Spring Harbor symposia on quantitative biology.

A Nucleolar Isoform of the Fbw7 Ubiquitin Ligase Regulates c-Myc and Cell Size

B. Clurman, R. Eisenman, A. Orian, 2004, Current Biology.

DamID: a methylation-based chromatin profiling approach.

A. Orian, M. Abed, D. Kenyagin-Karsenti, 2009, Methods in molecular biology.

Hairy Transcriptional Repression Targets and Cofactor Recruitment in Drosophila

J. Delrow, A. Orian, S. Parkhurst, 2004, PLoS biology.

Implementation of CRISPR/Cas9 Genome Editing to Generate Murine Lung Cancer Models That Depict the Mutational Landscape of Human Disease

F. Bassermann, A. Schulze, A. Orian, 2021, Frontiers in Cell and Developmental Biology.

SCFβ‐TrCP ubiquitin ligase‐mediated processing of NF‐κB p 105 requires phosphorylation of its C‐terminus by IκB kinase

A. Ciechanover, A. Israël, A. Orian, 2000 .

Structural Motifs Involved in Ubiquitin-Mediated Processing of the NF-κB Precursor p105: Roles of the Glycine-Rich Region and a Downstream Ubiquitination Domain

A. Ciechanover, A. Israël, A. Orian, 1999, Molecular and Cellular Biology.

Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105. Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation.

A. Ciechanover, A. Israël, A. Orian, 1995, The Journal of biological chemistry.

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

B. Clurman, J. Harper, R. Eisenman, 2004, Proceedings of the National Academy of Sciences of the United States of America.

The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis

A. Orian, F. Finkernagel, M. Eilers, 2010, The Journal of cell biology.

Nuclear organization and regulation of the differentiated state

A. Orian, Eliya Bitman-Lotan, 2021, Cellular and Molecular Life Sciences.

Sef is an inhibitor of proinflammatory cytokine signaling, acting by cytoplasmic sequestration of NF-κB.

A. Orian, Y. Carmi, D. Ron, 2012, Developmental cell.

Targeting the Ubiquitin-Dependent Transcriptional and Epigenetic Landscape in Cancer

A. Orian, E. Avitan-Hersh, 2017, Current Pharmacology Reports.

Chromatin, nuclear lamins, and maintenance of the differentiated identity

A. Orian, Eliya Bitman-Lotan, 2018, Current Opinion in Systems Biology.

Degradation of nuclear oncoproteins by the ubiquitin system in vitro.

A Ciechanover, A. Ciechanover, A. Orian, 1991, Proceedings of the National Academy of Sciences of the United States of America.

SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase.

A. Ciechanover, A. Israël, A. Orian, 2000, The EMBO journal.

A Non-stop identity complex (NIC) supervises enterocyte identity and protects from premature aging

T. Druley, A. Orian, N. Erez, 2020, bioRxiv.

Processing of p105 Is Inhibited by Docking of p50 Active Subunits to the Ankyrin Repeat Domain, and Inhibition Is Alleviated by Signaling via the Carboxyl-terminal Phosphorylation/ Ubiquitin-Ligase Binding Domain*

A. Ciechanover, A. Orian, Shai Cohen, 2001, The Journal of Biological Chemistry.

Multiple RTK pathways downregulate Groucho-mediated repression in Drosophila embryogenesis

Z. Paroush, G. Jiménez, A. Orian, 2008, Development.

The ubiquitin‐mediated proteolytic pathway: Mode of action and clinical implications

A. Ciechanover, A. Orian, A. Schwartz, 2000, Journal of cellular biochemistry. Supplement.

Degradation of the proto-oncogene product c-Fos by the ubiquitin proteolytic system in vivo and in vitro: identification and characterization of the conjugating enzymes

A. Ciechanover, A. Orian, A. Schwartz, 1995, Molecular and cellular biology.

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.

A. Ciechanover, A. Orian, A. Yaron, 1995, Proceedings of the National Academy of Sciences of the United States of America.

SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation

Jian Zhang, Xinyi Liu, A. Orian, 2015, Protein & Cell.

A Myc–Groucho complex integrates EGF and Notch signaling to regulate neural development

Z. Paroush, J. Delrow, R. Eisenman, 2007, Proceedings of the National Academy of Sciences.

Drosophila HUWE1 Ubiquitin Ligase Regulates Endoreplication and Antagonizes JNK Signaling During Salivary Gland Development

A. Orian, M. Eilers, Y. Zohar, 2018, Cells.

Regulation of Protein-Protein Interactions by the SUMO and Ubiquitin Pathways

A. Orian, Yifat Yanku, 2012 .

Hyd ubiquitinates the NF-κB co-factor Akirin to activate an effective immune response in Drosophila

M. Boutros, A. Orian, X. Nguyen, 2018, bioRxiv.

Mechanisms of ubiquitin-mediated, limited processingof the NF-κB1 precursor protein p105

A. Ciechanover, A. Israël, A. Orian, 2001 .

Gut microbiota dependent anti-tumor immunity restricts Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5−/− mice melanoma growth in Rnf5−/− mice

E. Ruppin, S. Yooseph, K. Flaherty, 2020 .

Stabilisation of β-Catenin-WNT signalling by USP10 in APC-truncated colorectal cancer drives cancer stemness and enables super-competitor signalling

A. Orian, F. Greten, M. Maurice, 2023, bioRxiv.

Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5−/− mice

E. Ruppin, Dennie T. Frederick, A. Orian, 2019, Nature Communications.

Multiple RTK pathways downregulate Groucho-mediated repression in Drosophila embryogenesis

Z. Paroush, G. Jiménez, A. Orian, 2008, Development.

TGF-beta flips the Myc switch.

R. Eisenman, A. Orian, 2001, Science's STKE : signal transduction knowledge environment.