I. Tooyama

S. Morikawa, M. Morita, T. Inubushi, 2007, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine.

Light and electron microscopy of neuropeptide Y-containing nerves in human liver, gallbladder, and pancreas.

H. Kimura, I. Tooyama, W. Ding, 1991, Gastroenterology.

Mapping of NPR-B immunoreactivity in the brainstem of Macaca fascicularis

I. Tooyama, E. Abdelalim, 2011, Brain Structure and Function.

NPR-C is expressed in the cholinergic and dopaminergic amacrine cells in the rat retina

I. Tooyama, E. Abdelalim, 2010, Peptides.

Distribution of natriuretic peptide receptor-C immunoreactivity in the rat brainstem and its relationship to cholinergic and catecholaminergic neurons

I. Tooyama, S. Yamamoto, J. Bellier, 2008, Neuroscience.

Demonstration of fibroblast growth factor receptor‐I in human prostate by polymerase chain reaction and immunohistochemistry

H. Kimura, I. Tooyama, T. Yoshiki, 1995, The Prostate.

BNP Signaling Is Crucial For Embryonic Stem Cell Proliferation

I. Tooyama, E. Abdelalim, 2009, PloS one.

Expression and localization of lactotransferrin mRNA in the cortex of Alzheimer’s disease

T. Beach, D. Walker, J. Rogers, 2009 .

Acidic fibroblast growth factor-like immunoreactivity in rat brain following cerebral infarction

H. Kimura, I. Tooyama, P. Mcgeer, 1994, Brain Research.

Immunohistochemical localization in the rat brain of an epitope corresponding to the fibroblast growth factor receptor-1

H. Kimura, S. Isobe, I. Tooyama, 1994, Neuroscience.

Molecular cloning of BNP from heart and its immunohistochemical localization in the hypothalamus of monkey

I. Tooyama, T. Takada, R. Torii, 2006, Peptides.

The MR tracking of transplanted ATDC5 cells using fluorinated poly-L-lysine-CF3.

S. Morikawa, M. Morita, T. Inubushi, 2007, Biomaterials.

Regulation of neuronal nitric oxide synthase in rat adrenal medulla.

I. Tooyama, N. Iwai, M. Kinoshita, 1995, Hypertension.

Co-expression pattern of neuronal nitric oxide synthase and two variants of choline acetyltransferase in myenteric neurons of porcine ileum

H. Kimura, I. Tooyama, W. Neuhuber, 2004, Journal of Chemical Neuroanatomy.

NPR-C protects embryonic stem cells from apoptosis by regulating p53 levels.

I. Tooyama, E. Abdelalim, 2012, Stem cells and development.

Variations in the BDNF Gene in Autopsy-Confirmed Alzheimer’s Disease and Dementia with Lewy Bodies in Japan

S. Shimohama, I. Tooyama, M. Takeda, 2006, Dementia and Geriatric Cognitive Disorders.

Immunohistochemical localization of GABAA receptors in comparison with GABA-immunoreactive structures in the nucleus tractus solitarii of the rat

H. Kimura, I. Tooyama, K. Terai, 1997, Neuroscience.

Immunoreactivity for Choline Acetyltransferase of Peripheral-Type (pChAT) in the Trigeminal Ganglion Neurons of the Non-Human Primate Macaca fascicularis

H. Kimura, I. Tooyama, J. Bellier, 2013, Acta histochemica et cytochemica.

Expression of NPR-B in neurons of the dorsal root ganglia of the rat

I. Tooyama, J. Bellier, E. Abdelalim, 2013, Peptides.

Immunohistochemical study of A2B5-positive ganglioside in postmortem human brain tissue of Alzheimer disease, amyotrophic lateral sclerosis, progressive supranuclear palsy and control cases

I. Tooyama, P. Mcgeer, Seung U. Kim, 1992, Neuroscience Letters.

Evaluation of Focal Cerebral Ischemia in Rats by Magnetic Resonance Imaging and Immunohistochemical Analyses

H. Kimura, S. Morikawa, T. Inubushi, 1998, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Immunohistochemical demonstration of choline acetyltransferase of a peripheral type (pChAT) in the enteric nervous system of rats

H. Kimura, I. Tooyama, O. Yasuhara, 2000, Journal of Chemical Neuroanatomy.

Generation of a Monoclonal Antibody Specifically Reacting with Neuron-specific TATA-Box Binding Protein-Associated Factor 1 (N-TAF1)

I. Tooyama, G. Tamiya, S. Makino, 2012 .

A Fluorine-19 Magnetic Resonance Probe, Shiga-Y5, Downregulates Thioredoxin-Interacting Protein Expression in the Brain of a Mouse Model of Alzheimer’s Disease

D. Yanagisawa, I. Tooyama, H. Taguchi, 2021, Molecules.

Successful vitrification of whole juvenile testis in the critically endangered cyprinid honmoroko (Gnathopogon caerulescens)

I. Tooyama, T. Takada, S. Higaki, 2017, Zygote.

A single pre-training glucose injection induces memory facilitation in rodents performing various tasks: contribution of acidic fibroblast growth factor

I. Tooyama, T. Hori, Kenji Suzuki, 1998, Neuroscience.

Production of monoclonal antibody against histamine and its application to immunohistochemical study in the stomach

H. Kimura, I. Tooyama, T. Sakata, 1998, The Histochemical Journal.

An insight into the neuroprotective and anti-neuroinflammatory effects and mechanisms of Moringa oleifera

D. Yanagisawa, I. Tooyama, W. Z. Wan Ngah, 2023, Frontiers in Pharmacology.

Immunohistochemical demonstration of GABAB receptors in the rat gastrointestinal tract

H. Kimura, I. Tooyama, K. Kuriyama, 1996, Neurochemical Research.

Immunohistochemical localization of taurine-conjugated bile acids in the liver of mouse, rat, monkey and human.

H. Kimura, I. Tooyama, W. Ding, 1994, Advances in experimental medicine and biology.

Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice

D. Yanagisawa, I. Tooyama, W. Z. Wan Ngah, 2018, Journal of Alzheimer's disease : JAD.

Effect of acidic fibroblast growth factor on basal forebrain cholinergic neurons in senescence-accelerated mice

H. Kimura, I. Tooyama, Y. Oomura, 1997, Experimental Gerontology.

Protection against Impairment of Memory and Immunoreactivity in Senescence‐Accelerated Mice by Acidic Fibroblast Growth Factor a

H. Kimura, I. Tooyama, Y. Oomura, 1996, Annals of the New York Academy of Sciences.

Mapping of FGF1 in the Medulla Oblongata of Macaca fascicularis

I. Tooyama, T. Imamura, E. Abdelalim, 2012, Acta histochemica et cytochemica.

Ameliorative effects of acetyl-l-carnitine and acidic fibroblast growth factor fragment analog on brain lipid hydroperoxide level, passive avoidance learning and/or immunoreactivity for choline acetyltransferase in the medial septum in senescence-accelerated mice

H. Kimura, I. Tooyama, Y. Oomura, 2004 .

Acidic fibroblast growth factor (FGF-1) in the anterior horn cells of ALS and control cases

H. Kimura, I. Tooyama, I. Akiguchi, 2001, Neuroreport.

Effects of an acidic fibroblast growth factor fragment analog on learning and memory and on medial septum cholinergic neurons in senescence-accelerated mice

H. Kimura, I. Tooyama, Y. Oomura, 1999, Neuroscience.

Increased expression of hippocampal cholinergic neurostimulating peptide-related components and their messenger RNAs in the hippocampus of aged senescence-accelerated mice

H. Kimura, I. Tooyama, N. Matsukawa, 1999, Neuroscience.

2-Buten-4-olide, an endogenous feeding suppressant, improves spatial performance through brain acidic fibroblast growth factor in mice

I. Tooyama, Y. Oomura, Ai-jun Li, 2001, Brain Research Bulletin.

Taste detection and recognition thresholds in Japanese patients with Alzheimer-type dementia.

D. Yanagisawa, I. Tooyama, A. Shiino, 2017, Auris, nasus, larynx.

Localization of Fibroblast Growth Factor-1 in Cholinergic Neurons Innervating the Rat Larynx

H. Kimura, I. Tooyama, Y. Oomura, 2006, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Demonstration of Fibroblast Growth Factor Receptor-1 in Rat Adrenal Gland as Revealed by Reverse Transcription-polymerase Chain Reaction and Immunohistochemistry

H. Kimura, I. Tooyama, Y. Oomura, 2003 .

Primary structure of GAP‐43 mRNA expressed in the spinal cord of ALS patients

I. Tooyama, J. Kimura, I. Akiguchi, 1998, Neuroreport.

Acidic and basic fibroblast growth factor-like immunoreactivity in the striatum and midbrain in Huntington's disease

H. Kimura, M. Hayden, I. Tooyama, 1993, Brain Research.

A Mechanistic Evaluation of Antioxidant Nutraceuticals on Their Potential against Age-Associated Neurodegenerative Diseases

I. Tooyama, Nur Zuliani Ramli, M. F. Yahaya, 2020, Antioxidants.

Expression of natriuretic peptide-activated guanylate cyclases by cholinergic and dopaminergic amacrine cells of the rat retina

I. Tooyama, C. Masuda, E. Abdelalim, 2008, Peptides.

Natriuretic peptides in embryonic stem cell-derived cardiomyocytes and their receptors in the CNS.

I. Tooyama, E. Abdelalim, 2009 .

Immunohistochemical mapping of natriuretic peptide receptor-A in the brainstem of Macaca fascicularis

I. Tooyama, T. Takada, R. Torii, 2007, Neuroscience.

C-type natriuretic peptide-like immunoreactivity in the rat inner ear

H. Kimura, I. Tooyama, M. Suzuki, 2000, Hearing Research.

Microglial Progranulin: Involvement in Alzheimer’s Disease and Neurodegenerative Diseases

D. Walker, I. Tooyama, Anarmaa Mendsaikhan, 2019, Cells.

I. Tooyama, Toshiharu Suzuki, M. Nishimura, 2012, Journal of neurochemistry.

New Proteomic Insights on the Role of NPR-A in Regulating Self-Renewal of Embryonic Stem Cells

I. Tooyama, Sameh Magdeldin, Tadashi Yamamoto, 2014, Stem Cell Reviews and Reports.

A mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease.

D. Yanagisawa, I. Tooyama, G. Tamiya, 2014, American journal of human genetics.

CG-containing oligonucleotides and transcription factor-binding motifs are enriched in human pericentric regions.

T. Abe, T. Ikemura, K. Wada, 2015, Genes & genetic systems.

The p53 inhibitor, pifithrin-α, suppresses self-renewal of embryonic stem cells.

I. Tooyama, E. Abdelalim, 2012, Biochemical and biophysical research communications.

Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein

D. Yanagisawa, I. Tooyama, Toshiharu Suzuki, 2020, Journal of Alzheimer's disease : JAD.

Curcumin against amyloid pathology in mental health and brain composition

D. Yanagisawa, I. Tooyama, W. Ngah, 2016 .

Gm14230 controls Tbc1d24 cytoophidia and neuronal cellular juvenescence

I. Tooyama, M. Nishimura, Takefumi Yamamoto, 2021, PloS one.

In vitro differentiation of fertile sperm from cryopreserved spermatogonia of the endangered endemic cyprinid honmoroko (Gnathopogon caerulescens)

I. Tooyama, T. Takada, S. Higaki, 2017, Scientific Reports.

Effective magnetic labeling of transplanted cells with HVJ-E for magnetic resonance imaging

S. Morikawa, T. Inubushi, I. Tooyama, 2004, Neuroreport.

Demonstration of Acidic Fibroblast Growth Factor (FGF-1) in Rat Adrenal Gland

H. Kimura, T. Taniguchi, I. Tooyama, 2001 .

Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-parkinsonism.

Katsuhito Yasuno, I. Tooyama, G. Tamiya, 2007, American journal of human genetics.

Expression profiles of cytokines in the brains of Alzheimer's disease (AD) patients compared to the brains of non-demented patients with and without increasing AD pathology.

T. Beach, I. Tooyama, L. Sue, 2011, Journal of Alzheimer's disease : JAD.

Volumetric changes in the aging rat brain and its impact on cognitive and locomotor functions

D. Yanagisawa, I. Tooyama, W. Ngah, 2017, Experimental Gerontology.

Fluorodopa is a Promising Fluorine‐19 MRI Probe for Evaluating Striatal Dopaminergic Function in a Rat Model of Parkinson's Disease

Y. Kitamura, D. Yanagisawa, S. Morikawa, 2016, Journal of neuroscience research.

Localization of Brain Natriuretic Peptide Immunoreactivity in Rat Spinal Cord

I. Tooyama, J. Bellier, E. Abdelalim, 2016, Front. Neuroanat..

α4 nicotinic acetylcholine receptor modulated by galantamine on nigrostriatal terminals regulates dopamine receptor-mediated rotational behavior

K. Takata, Y. Kitamura, D. Yanagisawa, 2016, Neurochemistry International.

Phylogenetic study of serotonin-immunoreactive structures in the pancreas of various vertebrates

H. Kimura, I. Tooyama, W. Ding, 1991, Cell and Tissue Research.

Halothane and Diazepam Inhibit Ketamine‐induced c‐fos Expression in the Rat Cingulate Cortex

Kenjiro Mori, Hiroshi Kimura, Masahiro Murakawa, 1996, Anesthesiology.

Immunohistochemical study of alpha 2 macroglobulin receptor in Alzheimer and control postmortem human brain.

S. Moestrup, I. Tooyama, P. Mcgeer, 1993, Molecular and chemical neuropathology.

Propofol Inhibits Ketamine-Induced c-fos Expression in the Rat Posterior Cingulate Cortex

H. Kimura, I. Tooyama, K. Shingu, 1998, Anesthesia and analgesia.

Immunohistochemical Mapping of TRK-Fused Gene Products in the Rat Brainstem

I. Tooyama, C. Masuda, Shigeko Takeuchi, 2012, Acta histochemica et cytochemica.

Expression and Localization of TRK-Fused Gene Products in the Rat Brain and Retina

H. Kimura, K. Fukui, I. Tooyama, 2011, Acta histochemica et cytochemica.

D. Yanagisawa, I. Tooyama, S. Makpol, 2017, Biochemical and biophysical research communications.

High-dose ketamine does not induce c-Fos protein expression in rat hippocampus

H. Kimura, I. Tooyama, O. Yasuhara, 1993, Neuroscience Letters.

Tocotrienol Rich Fraction Supplementation Modulate Brain Hippocampal Gene Expression in APPswe/PS1dE9 Alzheimer’s Disease Mouse Model

I. Tooyama, W. Z. Wan Ngah, S. Makpol, 2018, Journal of Alzheimer's disease : JAD.

Lignocaine–induced convulsion does not induce c–fos protein (c–Fos) in rat hippocampus

H. Kimura, I. Tooyama, O. Yasuhara, 1994, Acta anaesthesiologica Scandinavica.

Thioredoxin-Interacting Protein (TXNIP) with Focus on Brain and Neurodegenerative Diseases

D. Walker, I. Tooyama, Haruka Tsubaki, 2020, International journal of molecular sciences.

Detection of Viral DNA in the Endolymphatic Sac in Ménière’s Disease by in situ Hybridization

H. Kimura, I. Tooyama, Mikio Suzuki, 2003, ORL.

Alcohol consumption and cognitive function in elderly Japanese men.

I. Tooyama, H. Ueshima, N. Miyagawa, 2020, Alcohol.

Characterization of a Conformation-Restricted Amyloid β Peptide and Immunoreactivity of Its Antibody in Human AD brain.

D. Walker, I. Tooyama, H. Sugiyama, 2021, ACS chemical neuroscience.

Production of antiserum to [D‐Ala2]deltorphin I and its immunohistochemical application to the mouse brain

H. Kimura, I. Tooyama, T. Renda, 1992, NeuroReport.

Fate of (D-Ala2)-deltorphin-I-like immunoreactive neurons in 6-hydroxydopamine lesioned rat brain.

G. Di Chiara, H. Kimura, I. Tooyama, 2009, European journal of histochemistry : EJH.

Immunoreactive neurons in the brain of two mouse strains after incubation with an antiserum recognizing Asp-Val-Val-Gly.NH2 (DVVG), the C-terminal fragment of (D-Ala2)-deltorphin I

H. Kimura, S. Cabib, I. Tooyama, 2002, Journal of Chemical Neuroanatomy.

Ontogeny of (d-Ala2)-deltorphin I-like immunoreactive neurones in foetal rat brain

T. Maeda, H. Kimura, I. Tooyama, 2000, Journal of Chemical Neuroanatomy.

Postnatal development of [D‐Ala2]deltorphin‐I‐like immunoreactive structures in the rat brain

H. Kimura, I. Tooyama, T. Renda, 1994, The Journal of comparative neurology.

Immunohistochemical demonstration of [d-Ala2]deltorphin-I in amacrine cells of rat retina

H. Kimura, I. Tooyama, T. Renda, 1994, Peptides.

Interferon-γ plus lipopolysaccharide induction of delayed neuronal apoptosis in rat hippocampus

H. Kimura, P. Gebicke-haerter, Y. Kitamura, 1999, Neurochemistry International.

Kainic acid induction of heme oxygenase in vivo and in vitro

Y. Kitamura, T. Taniguchi, I. Tooyama, 1998, Neuroscience.

Subcellular localization of the low density lipoprotein receptor-related protein (α 2-macroglobulin receptor) in human brain

H. Kimura, S. Moestrup, I. Tooyama, 1995, Brain Research.

In Vivo Detection of Copper Ions by Magnetic Resonance Imaging Using a Prion-Based Contrast Agent

I. Tooyama, H. Yamada, Eric M. Yezdimer, 2012, Applied Biochemistry and Biotechnology.

Tocotrienol-Rich Fraction Modulates Amyloid Pathology and Improves Cognitive Function in AβPP/PS1 Mice

D. Yanagisawa, I. Tooyama, W. Z. Wan Ngah, 2016, Journal of Alzheimer's disease : JAD.

Localization of Thioredoxin-Interacting Protein in Aging and Alzheimer’s Disease Brains

D. Walker, I. Tooyama, Anarmaa Mendsaikhan, 2022, NeuroSci.

Anthropometric Obesity Indices were Stronger than CT-Based Indices in Associations with Carotid Intima-Media Thickness in Japanese Men

I. Tooyama, H. Arima, H. Ueshima, 2019, Journal of atherosclerosis and thrombosis.

Mapping of mitochondrial ferritin in the brainstem of Macaca fascicularis

I. Tooyama, J. Bellier, Mingchun Yang, 2016, Neuroscience.

Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction

D. Yanagisawa, I. Tooyama, W. Z. Wan Ngah, 2019, Journal of Alzheimer's disease : JAD.

Tocotrienol-rich fraction supplementation modulates antioxidant enzymes activity and reduces DNA damage in APPswe/PS1dE9Alzheimer’s Disease Mouse Model

I. Tooyama, S. Makpol, W. Ngah, 2016 .

Knockdown of p53 suppresses Nanog expression in embryonic stem cells.

I. Tooyama, E. Abdelalim, 2014, Biochemical and biophysical research communications.

Visualizing Hepatic Copper Release in Long–Evans Cinnamon Rats Using Single-Photon Emission Computed Tomography

I. Tooyama, H. Yamada, Eric M. Yezdimer, 2013, Applied Biochemistry and Biotechnology.

Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer’s Disease Brains

Tiffany M. Tang, L. Lue, T. Beach, 2020, International journal of molecular sciences.

Effects of neopterin on ischemic neuronal damage in gerbils

H. Kimura, I. Tooyama, H. Mori, 1994, Neuroscience Letters.

In vitro and in vivo induction of heme oxygenase‐1 in rat glial cells: Possible involvement of nitric oxide production from inducible nitric oxide synthase

H. Kimura, Y. Kitamura, T. Taniguchi, 1998, Glia.

Deposition of Alpha2-Macroglobulin in Fibrillar Type of Senile Plaques in the Brain of PS/APP-Transgenic Mice

I. Tooyama, T. Kondo, 2003 .

Relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities in the context of therapies for Alzheimer's disease.

Shigehiro Morikawa, Toshiro Inubushi, Nobuaki Shirai, 2010, Biomaterials.

Proteinuria and Reduced Estimated Glomerular Filtration Rate are Independently Associated With Lower Cognitive Abilities in Apparently Healthy Community-Dwelling Elderly Men in Japan: A Cross-sectional Study

T. Ohkubo, I. Tooyama, H. Ueshima, 2019, Journal of epidemiology.

Elevated Fasting Blood Glucose Levels Are Associated With Lower Cognitive Function, With a Threshold in Non-Diabetic Individuals: A Population-Based Study

I. Tooyama, H. Ueshima, N. Miyagawa, 2019, Journal of epidemiology.

Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice

D. Yanagisawa, S. Morikawa, I. Tooyama, 2015, Neurobiology of Aging.

Oxidative stress induction of DJ-1 protein

K. Takata, Y. Kitamura, D. Yanagisawa, 2017 .

Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury

K. Takata, Y. Kitamura, D. Yanagisawa, 2009, Oxidative medicine and cellular longevity.

Keto form of curcumin derivatives strongly binds to Aβ oligomers but not fibrils.

D. Yanagisawa, I. Tooyama, Y. Hirahara, 2021, Biomaterials.

Techniques and Methods Development of a method to measure Aβ42 in nasal cavity samples and its application in normal human volunteers

I. Tooyama, Takayuki Yamamoto, A. Shiino, 2015 .

Loss of Lysosomal Proteins Progranulin and Prosaposin Associated with Increased Neurofibrillary Tangle Development in Alzheimer Disease.

T. Beach, D. Walker, I. Tooyama, 2021, Journal of Neuropathology and Experimental Neurology.

Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer’s disease and aged brains: increased levels correlate with neuropathology

L. Lue, T. Beach, D. Walker, 2019, Acta Neuropathologica Communications.

Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body

I. Tooyama, E. Sasaki, H. Miyoshi, 2016, Scientific Reports.

Functional anatomy of the basal ganglia in X‐linked recessive dystonia‐parkinsonism

J. Kuratsu, I. Tooyama, G. Tamiya, 2005, Annals of neurology.

Enhancement of Progenitor Cell Division in the Dentate Gyrus Triggered by Initial Limbic Seizures in Rat Models of Epilepsy

H. Kimura, I. Tooyama, P. Mcgeer, 2000, Epilepsia.

Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats.

K. Takata, Y. Kitamura, D. Yanagisawa, 2007, FEBS letters.

Correlation of the Expression Level of C1q mRNA and the Number of C1q-Positive Plaques in the Alzheimer Disease Temporal Cortex

T. Beach, D. Walker, I. Tooyama, 2001, Dementia and Geriatric Cognitive Disorders.

Lactotransferrin immunocytochemistry in Alzheimer and normal human brain.

D. Walker, I. Tooyama, P. Mcgeer, 1993, The American journal of pathology.

Infiltration of T Lymphocytes and Expression of ICAM-1 in the Hippocampus of Patients with Hippocampal Sclerosis

T. Beach, I. Tooyama, N. Yamada, 2010, Acta histochemica et cytochemica.

A protein encoded by an alternative splice variant of choline acetyltransferase mRNA is localized preferentially in peripheral nerve cells and fibers

H. Kimura, I. Tooyama, 2000, Journal of Chemical Neuroanatomy.

The FAM3 superfamily member ILEI ameliorates Alzheimer’s disease-like pathology by destabilizing the penultimate amyloid-β precursor

I. Tooyama, M. Nishimura, S. Murayama, 2014, Nature Communications.

Novel curcumin derivatives as potent inhibitors of amyloid β aggregation

D. Yanagisawa, S. Morikawa, I. Tooyama, 2015, Biochemistry and biophysics reports.

Synthesis and Tautomerism of Curcumin Derivatives and Related Compounds

D. Yanagisawa, S. Morikawa, I. Tooyama, 2014 .

Curcuminoid binds to amyloid-β1-42 oligomer and fibril.

D. Yanagisawa, I. Tooyama, A. Yamamoto, 2011, Journal of Alzheimer's disease : JAD.

Development of a High-Sensitivity Method for the Measurement of Human Nasal Aβ42, Tau, and Phosphorylated Tau

I. Tooyama, K. Miura, A. Shiino, 2018, Journal of Alzheimer's disease : JAD.

Neuroprotective Effects of Casein-Derived Peptide Met-Lys-Pro (MKP) in a Hypertensive Model

D. Yanagisawa, S. Morikawa, I. Tooyama, 2020, Frontiers in Neuroscience.

Identification of juvenility-associated genes in the mouse hepatocytes and cardiomyocytes

I. Tooyama, Yosuke Kadota, F. A. Jam, 2018, Scientific Reports.

Voluntary running exercise after focal cerebral ischemia ameliorates dendritic spine loss and promotes functional recovery

D. Yanagisawa, I. Tooyama, S. Inoue, 2021, Brain Research.

NPR-A regulates self-renewal and pluripotency of embryonic stem cells

I. Tooyama, E. Abdelalim, 2011, Cell Death and Disease.

Transcriptome analysis revealed Bisphenol A and Nonylphenol affect reproduction.

I. Tooyama, Tomoaki Tanaka, T. Takada, 2019, Reproductive toxicology.

Neuroprotective effects of NBQX on hypoxia-induced neuronal damage in rat hippocampus.

H. Kimura, Y. Kitamura, T. Taniguchi, 1995, Neuroreport.

Differential accumulation of tau pathology between reciprocal F1 hybrids of rTg4510 mice

D. Yanagisawa, I. Tooyama, Aslina Pahrudin Arrozi, 2021, Scientific Reports.

Immunohistochemical and biochemical evidence for the presence of serotonin-containing neurons and nerve fibers in the octopus arm

H. Kimura, I. Tooyama, S. Farouk, 2017, Brain Structure and Function.

Phylogenetic and ontogenetic study of neuropeptide Y-containing nerves in the liver

H. Kimura, I. Tooyama, W. Ding, 1994, The Histochemical Journal.

High molecular weight basic fibroblast growth factor-like protein is localized to a subpopulation of mesencephalic dopaminergic neurons in the rat brain

I. Tooyama, P. Mcgeer, E. Mcgeer, 1992, Brain Research.

Identification and localization of a neuron-specific isoform of TAF1 in rat brain: implications for neuropathology of DYT3 dystonia

A. Graybiel, I. Tooyama, R. Kaji, 2011, Neuroscience.

Choline acetyltransferase immunopositive neurons in the lateral septum

L. Hersh, H. Kimura, I. Tooyama, 1990, Brain Research.

Immunohistochemical study of TAFII250 in the rat laryngeal nervous system.

H. Kimura, I. Tooyama, G. Tamiya, 2005, Histology and histopathology.

Demonstration of Cholinergic Ganglion Cells in Rat Retina: Expression of an Alternative Splice Variant of Choline Acetyltransferase

H. Kimura, I. Tooyama, O. Yasuhara, 2003, The Journal of Neuroscience.

Innervation of rat iris by trigeminal and ciliary neurons expressing pChAT, a novel splice variant of choline acetyltransferase

H. Kimura, I. Tooyama, O. Yasuhara, 2004, The Journal of comparative neurology.

Efficient delivery of chlorin e6 into ovarian cancer cells with octalysine conjugated superparamagnetic iron oxide nanoparticles for effective photodynamic therapy.

I. Tooyama, Hongmei Qin, N. Komatsu, 2016, Journal of materials chemistry. B.

An Increase of cell proliferation in the early post-irradiation phase in the hippocampus of the adult cynomolgus monkey (Macaca fascicularis)(Basic Medicine)

I. Tooyama, N. Mori, K. Takebayashi, 2011 .

Distinct Localization of Peripheral and Central Types of Choline Acetyltransferase in the Rat Cochlea

H. Kimura, I. Tooyama, H. Kitano, 2013, Acta histochemica et cytochemica.

Axotomy alters alternative splicing of choline acetyltransferase in the rat dorsal motor nucleus of the vagus nerve

H. Kimura, I. Tooyama, S. Kimura, 2009, The Journal of comparative neurology.

The production of antibodies that distinguish rat choline acetyltransferase from its splice variant product of a peripheral type

H. Kimura, I. Tooyama, S. Kimura, 2007, Neurochemistry International.

Rat choline acetyltransferase of the peripheral type differs from that of the common type in intracellular translocation

H. Kimura, I. Tooyama, Naoaki Saito, 2005, Neurochemistry International.

A new brain glucosensor and its physiological significance.

H. Kimura, I. Tooyama, N. Yanaihara, 1992, The American journal of clinical nutrition.

The effect of α-tocopherol, α- and γ-tocotrienols on amyloid-β aggregation and disaggregation in vitro

D. Yanagisawa, I. Tooyama, K. Ono, 2021, Biochemistry and biophysics reports.

Effects of fibroblast growth factors and platelet-derived growth factor on food intake in rats

H. Kimura, I. Tooyama, Y. Oomura, 1991, Brain Research Bulletin.

Kainic acid-induced inducible cyclooxygenase and c-Jun phosphorylation in the rat hippocampal formation

H. Kimura, K. Takata, Y. Kitamura, 1999, Brain Research.

Mitochondrial ferritin protects SH-SY5Y cells against H2O2-induced oxidative stress and modulates α-synuclein expression

D. Yanagisawa, I. Tooyama, T. Nonaka, 2017, Experimental Neurology.

In vivo induction of inducible nitric oxide synthase by microinjection with interferon‐γ and lipopolysaccharide in rat hippocampus

H. Kimura, Y. Kitamura, T. Taniguchi, 1996 .

Two modes of corticospinal reinnervation occur close to spinal targets following unilateral lesion of the motor cortex in neonatal hamsters

I. Tooyama, O. Yasuhara, H. Kimura, 1999, Neuroscience.

Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease

K. Hirayama, I. Tooyama, P. Mcgeer, 1994, Acta Neuropathologica.

Mitochondrial ferritin affects mitochondria by stabilizing HIF-1α in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration

D. Yanagisawa, I. Tooyama, K. Morino, 2016, Neurobiology of Aging.

Association of Immune Response and Neuronal Cell Death in the Rat Brain After Kainic Acid or Electrical Kindling Treatment

Hiroshi Kimura, Eiji Nakagawa, H. Kimura, 1998 .

Amyloid imaging using high-field magnetic resonance.

D. Yanagisawa, S. Morikawa, I. Tooyama, 2010, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine.

Columnar arragement of β-amyloid protein deposits in the cerebral cortex of patients with Alzheimer's disease

I. Tooyama, P. Mcgeer, H. Akiyama, 2004, Acta Neuropathologica.

Effect of selective serotonin reuptake inhibitors via 5-HT1A receptors on L-DOPA-induced rotational behavior in a hemiparkinsonian rat model.

K. Yoshimoto, K. Takata, Y. Kitamura, 2012, Journal of pharmacological sciences.

Expression and Localization of Mitochondrial Ferritin mRNA in Alzheimer's Disease Cerebral Cortex

T. Beach, I. Tooyama, Ligang Wang, 2011, PloS one.

Identification and localization of neuron-specific isoform of TAF 1 in rat brain : implications for neuropathology of DYT 3 dystonia

Keiko, A. Graybiel, I. Tooyama, 2011 .

Neuroepithelial cell competition triggers loss of cellular juvenescence

I. Tooyama, M. Nishimura, Takefumi Yamamoto, 2020, Scientific Reports.

Transition metal abnormalities in progressive dementias

I. Tooyama, Mari Yoshida, Eric M. Yezdimer, 2012, BioMetals.

Upregulation of mitochondrial ferritin by proinflammatory cytokines: implications for a role in Alzheimer's disease.

S. Vincent, D. Yanagisawa, I. Tooyama, 2015, Journal of Alzheimer's disease : JAD.

Fluorine-19 Magnetic Resonance Imaging for Detection of Amyloid β Oligomers Using a Keto Form of Curcumin Derivative in a Mouse Model of Alzheimer’s Disease

D. Yanagisawa, S. Morikawa, I. Tooyama, 2021, Molecules.

Study of tau pathology in male rTg4510 mice fed with a curcumin derivative Shiga-Y5

D. Yanagisawa, I. Tooyama, H. Taguchi, 2018, PloS one.

Amyloid imaging using fluorine-19 magnetic resonance imaging (19F-MRI)

D. Yanagisawa, S. Morikawa, T. Inubushi, 2016, Ageing Research Reviews.

Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using 19F magnetic resonance imaging

S. Morikawa, I. Tooyama, I. Nakano, 2009, Neuroscience Research.

Morphometric characterization of Binswanger's disease: comparison with Alzheimer's disease.

K. Nozaki, T. Inubushi, I. Tooyama, 2012, European journal of radiology.

DJ-1 Protects against Neurodegeneration Caused by Focal Cerebral Ischemia and Reperfusion in Rats

K. Takata, Y. Kitamura, D. Yanagisawa, 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Interferon-gamma plus lipopolysaccharide induction of delayed neuronal apoptosis in rat hippocampus.

H. Kimura, P. Gebicke-haerter, Y. Kitamura, 1999, Neurochemistry International.

TRK-fused Gene Protein Localization Is Prominent in Serotonergic and Noradrenergic Cell Groups, and Some Lower Motor Neurons in the Corticospinal Tract of the Rat Brainstem

I. Tooyama, Shigeko Takeuchi, 2018, Acta histochemica et cytochemica.

Time course of in vitro expression of NADPH-diaphorase in cultured rat brain neurons: comparison with in vivo expression.

H. Kimura, T. Taniguchi, I. Tooyama, 1991, Brain research. Developmental brain research.

Actions of acidic fibroblast growth factor fragments on food intake in rats.

H. Kimura, I. Tooyama, Y. Oomura, 1995, Obesity research.

Effects of fibroblast growth factors and related peptides on food intake by rats

H. Kimura, H. Yagi, I. Tooyama, 1994, Physiology & Behavior.

Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients

T. Beach, S. Shimohama, I. Tooyama, 2015, Neuroscience Letters.

Kainic acid induces expression of caveolin-1 in activated microglia in rat brain.

Wakoto Matsuda, I. Tooyama, O. Yasuhara, 2013, Folia histochemica et cytobiologica.

Production of antisera to acidic fibroblast growth factor and their application to immunohistochemical study in rat brain

H. Kimura, I. Tooyama, Y. Oomura, 1991, Neuroscience.

Expression of inducible nitric oxide synthase in human thyroid papillary carcinomas.

H. Kimura, I. Tooyama, Y. Nakanishi, 1999, Thyroid : official journal of the American Thyroid Association.

Morphologic Study of Neuronal Death, Glial Activation, and Progenitor Cell Division in the Hippocampus of Rat Models of Epilepsy

H. Kimura, I. Tooyama, O. Yasuhara, 2002, Epilepsia.

Comparison of FGF1 (aFGF) Expression between the Dorsal Motor Nucleus of Vagus and the Hypoglossal Nucleus of Rat

I. Tooyama, Y. Oomura, S. Furukawa, 2006, Acta histochemica et cytochemica.

Identification of TEKTIN1‐expressing multiciliated cells during spontaneous differentiation of non‐human primate embryonic stem cells

I. Tooyama, A. Kurisaki, T. Takada, 2023, Genes to cells : devoted to molecular & cellular mechanisms.

In VivoHypoxia-Induced Neuronal Damage with an Enhancement of Neuronal Nitric Oxide Synthase Immunoreactivity in Hippocampus

H. Kimura, Y. Kitamura, T. Taniguchi, 1997, Experimental Neurology.

Overproduction of Gamma Interferon in B/Jas Inbred Rabbits with Herpes Simplex Virus Encephalitis

I. Tooyama, T. Isono, A. Seto, 1999, Microbiology and immunology.

Binding Avidity of Immunoglobulin G for Acetylcholine

H. Kimura, I. Tooyama, G. Peltre, 2003 .

Immunohistochemical Analysis of Mitochondrial Ferritin in the Midbrain of Patients with Parkinson’s Disease

D. Yanagisawa, I. Tooyama, K. Mukaisho, 2023, Acta histochemica et cytochemica.

Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals

I. Tooyama, R. Takahashi, T. Morimura, 2018, Scientific Reports.

Low-affinity nerve growth factor receptor immunoreactivity in the human urinary bladder

T. Maeda, K. Kitahama, I. Tooyama, 1995, Neuroscience Letters.

Vasopressin and oxytocin receptor mRNAs are expressed in the rat inner ear

H. Kimura, I. Tooyama, T. Takeda, 1997, Neuroreport.

Magnetic resonance imaging using hemagglutinating virus of Japan-envelope vector successfully detects localization of intra-cardially administered microglia in normal mouse brain

S. Morikawa, M. Morita, T. Inubushi, 2006, Neuroscience Letters.

Nasal Extracts from Patients with Alzheimer’s Disease Induce Tau Aggregates in a Cellular Model of Tau Propagation

D. Yanagisawa, I. Tooyama, Y. Hashizume, 2021, Journal of Alzheimer's disease reports.

New Proteomic Insights on the Role of NPR-A in Regulating Self-Renewal of Embryonic Stem Cells

I. Tooyama, Tadashi Yamamoto, Sameh Magdeldin, 2014, Stem Cell Reviews and Reports.

S6 kinase phosphorylated at T229 is involved in tau and actin pathologies in Alzheimer's disease

I. Tooyama, H. Akiyama, H. Mukai, 2016, Neuropathology : official journal of the Japanese Society of Neuropathology.

BNP signaling is crucial for embryonic stem cell proliferation

I. Tooyama, E. Abdelalim, 2011, BMC Pharmacology.

Regulation of Self-Renewal and Pluripotency of Embryonic Stem Cells: Role of Natriuretic Peptide Receptor A

I. Tooyama, E. Abdelalim, 2012 .

Acidic fibroblast growth factor-like immunoreactivity in brain of Alzheimer patients

H. Kimura, I. Tooyama, P. Mcgeer, 1991, Neuroscience Letters.

Acidic fibroblast growth factor protects memory and immunoreactivity impairment in senescence accelerated mice.

H. Kimura, I. Tooyama, Y. Oomura, 1995, Neurobiology.

The endoplasmic reticulum‐Golgi pathway is a target for translocation and aggregation of mutant superoxide dismutase linked to ALS

I. Tooyama, J. Julien, M. Urushitani, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Reactive Astrocytes Express Acidic Fibroblast Growth Factor in Alzheimer's Disease Brain

H. Kimura, I. Tooyama, P. Mcgeer, 1991 .

Relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities in the context of therapies for Alzheimer's disease.

K. Wada, S. Morikawa, T. Inubushi, 2010, Biomaterials.

Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury

K. Takata, Y. Kitamura, S. Morikawa, 2009, Oxidative medicine and cellular longevity.

Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain.

S. Morikawa, T. Inubushi, I. Tooyama, 2014, Journal of Alzheimer's disease : JAD.

Inhalable curcumin: offering the potential for translation to imaging and treatment of Alzheimer's disease.

J. Gore, I. Tooyama, D. Koktysh, 2015, Journal of Alzheimer's disease : JAD.

Optimization of 3D Immunofluorescence Analysis and Visualization Using IMARIS and MeshLab

I. Tooyama, W. Z. Wan Ngah, K. Mukaisho, 2023, Cells.

Effects of a DJ-1-Binding Compound on Spatial Learning and Memory Impairment in a Mouse Model of Alzheimer's Disease.

K. Takata, Y. Kitamura, S. Shimohama, 2016, Journal of Alzheimer's disease : JAD.

Regulation of inner ear fluid in the rat by vasopressin.

I. Tooyama, T. Takeda, K. Kitajima, 1999, Neuroreport.

Association of Arterial Stiffness and Atherosclerotic Burden With Brain Structural Changes Among Japanese Men

K. Nozaki, I. Tooyama, H. Ueshima, 2023, Journal of the American Heart Association.

Expression of Major Histocompatibility Complex Class I and II Antigens in the Hippocampus of Rats After Treatment with Kainic Acid

I. Tooyama, S. Uemura, Toshiaki Ootsubo, 1996 .

In vivo hypoxia-induced neuronal damage in dentate gyrus of rat hippocampus: changes in NMDA receptors and the effect of MK–801

H. Kimura, Y. Kitamura, T. Taniguchi, 1997, Neurochemistry International.

Nonylphenol reduced the number of haploids in in vitro spermatogenesis of the endangered cyprinid Gnathopogon caerulescens.

I. Tooyama, T. Takada, S. Higaki, 2023, Toxicology in vitro : an international journal published in association with BIBRA.

Association of step counts with cognitive function in apparently healthy middle-aged and older Japanese men

I. Tooyama, H. Ueshima, N. Miyagawa, 2024, Preventive medicine reports.

Distribution of natriuretic peptide receptor-C immunoreactivity in the rat brainstem and its relationship to cholinergic and catecholaminergic neurons

I. Tooyama, J. Bellier, Chiaki Masuda, 2008, Neuroscience.

Comparison of MR images and histochemical localization of intra-arterially administered microglia surrounding beta-amyloid deposits in the rat brain.

Y. Kitamura, S. Morikawa, T. Inubushi, 2006, Histology and histopathology.

In vivo detection of amyloid β deposition using 19F magnetic resonance imaging with a 19F-containing curcumin derivative in a mouse model of Alzheimer's disease

S. Morikawa, T. Inubushi, I. Tooyama, 2011, Neuroscience.

Novel fluorinated derivative of curcumin negatively regulates thioredoxin-interacting protein expression in retinal pigment epithelial and macrophage cells.

D. Walker, I. Tooyama, H. Taguchi, 2020, Biochemical and biophysical research communications.