J. Unitt

发表

Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression

James R. Johnson, D. Broomhead, D. Kell, 2004, Science.

Oscillations in NF-kappaB signaling control the dynamics of gene expression.

D B Kell, N Benson, D. Broomhead, 2004, Science.

Thermal Shift as an Entropy-Driven Effect.

J. Unitt, M. Redhead, R. Satchell, 2017, Biochemistry.

1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile.

J. Unitt, H. Hunt, J. Belanoff, 2015, Bioorganic & medicinal chemistry letters.

Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors.

Stuart Paine, John Unitt, J. Unitt, 2004, Bioorganic & medicinal chemistry letters.

Novel cobalt complex inhibitors of mitochondrial calcium uptake.

J. Unitt, A. Wallace, A. Ingall, 1999, Bioorganic & medicinal chemistry.

Dynamic analysis of STAT6 signalling in living cells

G. Nelson, D. Spiller, J. Unitt, 2002, FEBS letters.

The acute effects of the creatine analogue, beta-guanidinopropionic acid, on cardiac energy metabolism and function.

G. Radda, J. Unitt, A. Seymour, 1993, Biochimica et biophysica acta.

Determination of free creatine and phosphocreatine concentrations in the isolated perfused rat heart by 1H- and 31P-NMR.

G. Radda, J. Unitt, J. Schrader, 1992, Biochimica et biophysica acta.

Plant lectins are novel Toll-like receptor agonists.

J. Unitt, D. Hornigold, 2011, Biochemical pharmacology.

Development and Validation of a Simple Cell-Based Fluorescence Assay for Dipeptidyl Peptidase 1 (DPP1) Activity

J. Unitt, E. Ainscow, J. Pilling, 2011, Journal of biomolecular screening.

Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists.

J. Unitt, Bryan E. Roberts, A. Baxter, 2017, ACS medicinal chemistry letters.

FKBP5 mRNA Expression Is a Biomarker for GR Antagonism.

J. Unitt, H. Hunt, U. Bali, 2016, The Journal of clinical endocrinology and metabolism.

Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist.

J. Unitt, H. Hunt, J. Belanoff, 2017, Journal of medicinal chemistry.

Direct evidence for a role of intramitochondrial Ca2+ in the regulation of oxidative phosphorylation in the stimulated rat heart. Studies using 31P n.m.r. and ruthenium red.

J. Unitt, J. Mccormack, P. J. England, 1989, The Biochemical journal.

Dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airway diseases. 1. Discovery and biological evaluation of some 7-(2-aminoethyl)-4-hydroxybenzothiazol-2(3H)-one analogues.

R C Brown, A M Davis, W. T. Simpson, 1998, Journal of medicinal chemistry.

Hit-to-Lead studies: the discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists.

John Unitt, J. Unitt, A. Baxter, 2006, Bioorganic & medicinal chemistry letters.

Hit-to-lead studies: the discovery of potent, orally bioavailable triazolethiol CXCR2 receptor antagonists.

Bryan Roberts, John Unitt, J. Unitt, 2003, Bioorganic & medicinal chemistry letters.

Hydroxamates Myeloperoxidase by Aromatic Potent Reversible Inhibition of Enzymology

J. Unitt, A. Kettle, T. Sjögren, 2014 .

Potent Reversible Inhibition of Myeloperoxidase by Aromatic Hydroxamates*

G. Pairaudeau, J. Unitt, A. Kettle, 2013, The Journal of Biological Chemistry.

PSS288 - Potent Reversible Inhibition of Myeloperoxidase by Aromatic Hydroxamates

J. Unitt, A. Kettle, T. Sjögren, 2013 .

Multi-parameter analysis of the kinetics of NF-kappaB signalling and transcription in single living cells.

David G Spiller, G. Nelson, D. Spiller, 2002, Journal of cell science.

NF-κB signalling is inhibited by glucocorticoid receptor and STAT6 via distinct mechanisms

D. Ray, G. Nelson, D. Spiller, 2003, Journal of Cell Science.

Rat skeletal muscle metabolism in experimental heart failure: effects of physical training.

B. Rajagopalan, S. Adamopoulos, A. Coats, 1995, Acta physiologica Scandinavica.

Discovery of pyrazoles as novel FPR1 antagonists.

M. Wenlock, J. Unitt, Bryan E. Roberts, 2011, Bioorganic & medicinal chemistry letters.

A combinatorial biophysical approach; FTSA and SPR for identifying small molecule ligands and PAINs.

J. Unitt, D. Matulis, V. Petrauskas, 2015, Analytical biochemistry.

An evaluation of fluorescence polarization and lifetime discriminated polarization for high throughput screening of serine/threonine kinases.

Paul Hemsley, John Unitt, J. Unitt, 2002, Analytical biochemistry.

Pulsatile Stimulation Determines Timing and Specificity of NF-κB-Dependent Transcription

D. S. Broomhead, Claire V. Harper, D. Broomhead, 2009, Science.

Evaluation of the Biological Activity of Compounds: Techniques and Mechanism of Action Studies

J. Unitt, I. Dougall, 2015 .

Key Aspects of Modern GPCR Drug Discovery.

J. Unitt, R. Satchell, E. Rosethorne, 2023, SLAS discovery : advancing life sciences R & D.

Development of a high-throughput human rhinovirus infectivity cell-based assay for identifying antiviral compounds.

J. Unitt, C. McCrae, B. Thong, 2011, Journal of virological methods.

Fowler, A. et al. An evaluation of fluorescence polarization and lifetime discriminated polarization for high throughput screening of serine/threonine kinases. Anal. Biochem. 308, 223-231

J. Unitt, E. Sullivan, E. Longman, 2002 .

Discovery of small molecule human FPR1 receptor antagonists.

J. Unitt, R. Weaver, A. Baxter, 2009, Bioorganic & medicinal chemistry letters.