C. Gabel

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Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells.

A. Helenius, B. L. Granger, S. Green, 1990, The Journal of biological chemistry.

An 83 kDa O-GlcNAc-glycoprotein is found in the axoplasm and nucleus of Aplysia neurons

C. Gabel, R. Ambron, S. P. Elliot, 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Identification, Characterization, and Crystal Structure of the Omega Class Glutathione Transferases*

G Chelvanayagam, G. Chelvanayagam, D. Danley, 2000, The Journal of Biological Chemistry.

IL-1 beta maturation: evidence that mature cytokine formation can be induced specifically by nigericin.

C. Gabel, K. Geoghegan, A. Lanzetti, 1992, Journal of immunology.

Inhibition of interleukin-1 beta production by SKF86002: evidence of two sites of in vitro activity and of a time and system dependence.

C. Gabel, P. Connelly, D. Perregaux, 1995, Molecular pharmacology.

Human monocyte interleukin-1beta posttranslational processing. Evidence of a volume-regulated response.

C. Gabel, D. Perregaux, R. Laliberte, 1996, The Journal of biological chemistry.

Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells.

C. Gabel, J. Mcneish, J. Hambor, 2000, The Journal of experimental medicine.

Identification and characterization of cells deficient in the mannose 6-phosphate receptor: evidence for an alternate pathway for lysosomal enzyme targeting.

D. Goldberg, C. Gabel, S. Kornfeld, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Mannose processing is an important determinant in the assembly of phosphorylated high mannose-type oligosaccharides.

C. Gabel, D. Lazzarino, 1989, The Journal of biological chemistry.

Steps in the phosphorylation of the high mannose oligosaccharides of lysosomal enzymes.

A. Varki, D. Goldberg, C. Gabel, 1982, Ciba Foundation symposium.

Mannose 6‐Phosphate Receptors: Potential Mediators of Germ Cell‐Sertoli Cell Interactions a

D. A. O’Brien, C. Gabel, E. M. Eddy, 1991, Annals of the New York Academy of Sciences.

Selective retention of monoglucosylated high mannose oligosaccharides by a class of mutant vesicular stomatitis virus G proteins

C. Gabel, J. Bergmann, K. Suh, 1989, The Journal of cell biology.

Identification of methylphosphomannosyl residues as components of the high mannose oligosaccharides of Dictyostelium discoideum glycoproteins.

C. Gabel, S. Kornfeld, V. Reinhold, 1984, The Journal of biological chemistry.

A 58-kDa resident protein of the cis Golgi cisterna is not terminally glycosylated.

C. Gabel, M. Farquhar, K. Suh, 1991, The Journal of biological chemistry.

beta-Glucuronidase is transported slowly to lysosomes in BW5147 mouse lymphoma cells: evidence that the prelysosomal enzyme is not restricted to the endoplasmic reticulum.

C. Gabel, D. Lazzarino, 1990, Archives of biochemistry and biophysics.

Beyond Innate Immunity Posttranslational Processing: A Novel Role β Antimicrobial Peptides Initiate IL-1

C. Gabel, D. Perregaux, Jishu Shi, 2013 .

Antimicrobial Peptides Initiate IL-1β Posttranslational Processing: A Novel Role Beyond Innate Immunity

C. Gabel, D. Perregaux, Jishu Shi, 2002, The Journal of Immunology.

Varicella-zoster virus glycoprotein oligosaccharides are phosphorylated during posttranslational maturation

D. Sherman, C. Gabel, M. Gershon, 1989, Journal of virology.

Postendocytic maturation of acid hydrolases: evidence of prelysosomal processing

C. Gabel, S. Foster, 1987, The Journal of cell biology.

Discovery and Optimization of Triazolopyrimidinone Derivatives as Selective NLRP3 Inflammasome Inhibitors.

M. Bock, C. Gabel, M. Holloway, 2022, ACS medicinal chemistry letters.

After fertilization, sperm surface components remain as a patch in sea urchin and mouse embryos

C. Gabel, B. Shapiro, E. M. Eddy, 1979, Cell.

Correlation of polymorphic variation in the promoter region of the interleukin‐1β gene with secretion of interleukin‐1β protein

F. Breedveld, C. Gabel, T. Huizinga, 2004 .

Transduced Bone Marrow Macrophages Lipopolysaccharide/ATP Activation of IL-1F6 Occurs in Response to Externalization of the Leaderless Cytokine

C. Gabel, J. Sims, Jesse L. Gurgel, 2009 .

Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors.

C. Gabel, D. Perregaux, J. Eggler, 2001, The Journal of pharmacology and experimental therapeutics.

Interleukin‐1β posttranslational processing—exploration of P2X7 receptor involvement

C. Gabel, B. Koller, D. Perregaux, 2001 .

IL-18 in Human Blood and β Stimulus-Induced Secretion of IL-1 ATP Acts as an Agonist to Promote Conklyn and

C. Gabel, M. Conklyn, R. Laliberte, 2000 .

Mannose 6-phosphate receptor-mediated endocytosis of acid hydrolases: internalization of beta-glucuronidase is accompanied by a limited dephosphorylation

C. Gabel, S. Foster, 1986, The Journal of cell biology.

Derived protein sequence, oligosaccharides, and membrane insertion of the 120-kDa lysosomal membrane glycoprotein (lgp120): identification of a highly conserved family of lysosomal membrane glycoproteins.

A. Helenius, B. L. Granger, S. Green, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Tenidap and other anion transport inhibitors disrupt cytolytic T lymphocyte-mediated IL-1 beta post-translational processing.

C. Gabel, D. Perregaux, L. Svensson, 1996, Journal of immunology.

Structure-activity relationships of triazolopyridine oxazole p38 inhibitors: identification of candidates for clinical development.

F. Lombardo, A. Kalgutkar, E. Laird, 2006, Bioorganic & medicinal chemistry letters.

[125I]diiodofluorescein isothiocyanate: its synthesis and use as a reagent for labeling proteins and cells to high specific radioactivity.

C. Gabel, B. Shapiro, 1978, Analytical biochemistry.

Regional differentiation of the sperm surface as studied with 125I- diiodofluorescein isothiocyanate, an impermeant reagent that allows isolation of the labeled components

C. Gabel, B. Shapiro, E. M. Eddy, 1979, The Journal of cell biology.

Biosynthesis of the mannose 6-phosphate recognition marker in transport-impaired mouse lymphoma cells. Demonstration of a two-step phosphorylation.

C. Gabel, D. Lazzarino, 1988, The Journal of biological chemistry.

Processing of the asparagine-linked oligosaccharides of secreted and intracellular forms of the vesicular stomatitis virus G protein: in vivo evidence of Golgi apparatus compartmentalization

C. Gabel, J. Bergmann, 1985, The Journal of cell biology.

Lysosomal enzyme oligosaccharide phosphorylation in mouse lymphoma cells: specificity and kinetics of binding to the mannose 6-phosphate receptor in vivo

D. Goldberg, C. Gabel, S. Kornfeld, 1982, The Journal of cell biology.

Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535.

A. Kalgutkar, C. Gabel, R. Shepard, 2011, Bioorganic & medicinal chemistry letters.

Intracellular transport of newly synthesized varicella-zoster virus: final envelopment in the trans-Golgi network

D. Sherman, C. Gabel, R. Ambron, 1994, Journal of virology.

Cell- and ligand-specific dephosphorylation of acid hydrolases: evidence that the mannose 6-phosphatase is controlled by compartmentalization

C. Gabel, R. Einstein, 1991, The Journal of cell biology.

Serum factors alter the extent of dephosphorylation of ligands endocytosed via the mannose 6-phosphate/insulin-like growth factor II receptor

C. Gabel, R. Einstein, 1989, The Journal of cell biology.

Entry and egress of varicella-zoster virus

D. Sherman, C. Gabel, R. Ambron, 1995, Neurology.

Identification and characterization of cells deficient in the mannose 6-phosphate receptor: evidence for an alternate pathway for lysosomal enzyme targeting.

D. Goldberg, C. Gabel, S. Kornfeld, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Deficient glycosylation of arylsulfatase A in pseudo arylsulfatase-A deficiency

C. Gabel, P. Chang, D. Lazzarino, 1990, Molecular and Cellular Biochemistry.

EVIDENCE FOR A MANNOSE 6-PHOSPHATE-INDEPENDENT PATHWAY FOR LYSOSOMAL ENZYME TARGETING1

D. Goldberg, C. Gabel, S. Kornfeld, 1984 .

LL-Z1271a: An Interleukin-1 Production Inhibitor

C. Gabel, N. Kojima, H. Nishida, 2001 .

Characterization of oligosaccharides that bind to human anti-MAG antibodies and to the mouse monoclonal antibody HNK-1

C. Gabel, M. Shy, N. Latov, 1986, Journal of Neuroimmunology.

Lysosomal enzyme trafficking in mannose 6-phosphate receptor-positive mouse L-cells: demonstration of a steady state accumulation of phosphorylated acid hydrolases

C. Gabel, S. Foster, 1986, The Journal of cell biology.

Studies of the biosynthesis of the mannose 6-phosphate receptor in receptor-positive and -deficient cell lines

D. Goldberg, C. Gabel, S. Kornfeld, 1983, The Journal of cell biology.

Protein determinants impair recognition of procathepsin L phosphorylated oligosaccharides by the cation-independent mannose 6-phosphate receptor.

C. Gabel, D. Lazzarino, 1990, The Journal of biological chemistry.

Correlation of polymorphic variation in the promoter region of the interleukin-1 beta gene with secretion of interleukin-1 beta protein.

C. Gabel, T. Huizinga, A. Seymour, 2004, Arthritis and rheumatism.

Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X₇ receptor.

C. Gabel, R. Shepard, D. Perregaux, 2011, Bioorganic & medicinal chemistry letters.

Theoretical and experimental design of atypical kinase inhibitors: application to p38 MAP kinase.

Dennis E Danley, P. Lemotte, M. Mansour, 2005, Journal of medicinal chemistry.

Absence of the P2X7 Receptor Alters Leukocyte Function and Attenuates an Inflammatory Response

C. Gabel, L. Audoly, J. Wicks, 2002, The Journal of Immunology.

Molecular Alterations in Gamete Surfaces During Fertilization and Early Development

C. Gabel, B. Shapiro, R. Schackmann, 1980 .

Lysosomal enzyme phosphorylation in mouse lymphoma cell lines with altered asparagine-linked oligosaccharides.

C. Gabel, S. Kornfeld, 1982, Journal of Biological Chemistry.

Molecular approaches to the study of fertilization.

C. Gabel, B. Shapiro, R. Schackmann, 1981, Annual review of biochemistry.

High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1.

C. Gabel, J. Mcneish, G. Chimini, 2000, Proceedings of the National Academy of Sciences of the United States of America.

An intermediate state of fertilization involved in internalization of sperm components.

C. Gabel, B. Shapiro, G. Gundersen, 1982, Developmental biology.

Post-Translational Processing of Murine IL-1: Evidence that ATP-Induced Release of IL-1α and IL-1β Occurs via a Similar Mechanism

C. Gabel, D. Perregaux, 1998, The Journal of Immunology.

Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.

C. Gabel, D. Perregaux, 1994, The Journal of biological chemistry.

Mouse Sertoli cells secrete mannose 6-phosphate containing glycoproteins that are endocytosed by spermatogenic cells.

D. A. O’Brien, C. Gabel, E. M. Eddy, 1993, Biology of reproduction.

Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice.

C. Gabel, Xiuwei Tang, Yucui Zhu, 2005, The Journal of investigative dermatology.

Envelopment of varicella-zoster virus: targeting of viral glycoproteins to the trans-Golgi network

C. Gabel, R. Ambron, M. Gershon, 1995, Journal of virology.

Tenidap modulates cytoplasmic pH and inhibits anion transport in vitro. I. Mechanism and evidence of functional significance.

C. Gabel, L. Svensson, C. Pazoles, 1994, Journal of immunology.

Altered Cytokine Production in Mice Lacking P2X7Receptors*

Beverly H. Koller, C. Gabel, B. Koller, 2001, The Journal of Biological Chemistry.

ATP Acts as an Agonist to Promote Stimulus-Induced Secretion of IL-1β and IL-18 in Human Blood

C. Gabel, D. Perregaux, M. Conklyn, 2000, The Journal of Immunology.

ATP Treatment of Human Monocytes Promotes Caspase-1 Maturation and Externalization*

C. Gabel, J. Eggler, R. Laliberte, 1999, The Journal of Biological Chemistry.

Human monocyte stimulus-coupled IL-1beta posttranslational processing: modulation via monovalent cations.

C. Gabel, D. Perregaux, 1998, The American journal of physiology.

Human monocyte stimulus-coupled IL-1β posttranslational processing: modulation via monovalent cations.

C. Gabel, D. Perregaux, 1998, American journal of physiology. Cell physiology.

Externalization of the Leaderless Cytokine IL-1F6 Occurs in Response to Lipopolysaccharide/ATP Activation of Transduced Bone Marrow Macrophages

C. Gabel, J. Sims, Jesse L. Gurgel, 2009, The Journal of Immunology.

Sulfate contributes to the negative charge of podocalyxin, the major sialoglycoprotein of the glomerular filtration slits.

C. Gabel, G. Dekan, M. Farquhar, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Interleukin-36 (IL-36) Ligands Require Processing for Full Agonist (IL-36α, IL-36β, and IL-36γ) or Antagonist (IL-36Ra) Activity

C. Gabel, J. Sims, B. Lipsky, 2011, The Journal of Biological Chemistry.

Reduction of intracellular pH by tenidap. Involvement of cellular anion transporters in the pH change.

C. Gabel, R. Robinson, P. McNiff, 1995, Biochemical pharmacology.

Inhibition of cytokine activation processes in vitro by tenidap, a novel anti-inflammatory agent.

C. Gabel, L. Svensson, R. Laliberte, 1995, Cytokine.

Tenidap modulates cytoplasmic pH and inhibits anion transport in vitro. II. Inhibition of IL-1 beta production from ATP-treated monocytes and macrophages.

C. Gabel, D. Perregaux, L. Svensson, 1994, Journal of immunology.

Synthesis of covalent [14C]-labeled diarylsulfonylurea (DASU) inhibitors of the processing and release of IL-1

C. Gabel, J. Weaver, J. Eggler, 2002 .

Glutathione S-Transferase Omega 1-1 Is a Target of Cytokine Release Inhibitory Drugs and May Be Responsible for Their Effect on Interleukin-1β Posttranslational Processing*

C. Gabel, K. Geoghegan, P. Rosner, 2003, The Journal of Biological Chemistry.

Infection of cells by varicella zoster virus: inhibition of viral entry by mannose 6-phosphate and heparin.

C. Gabel, R. Ambron, M. Gershon, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2)*

C. Gabel, O. Silvennoinen, N. Walker, 2015, The Journal of Biological Chemistry.

Acidification-dependent dissociation of endocytosed insulin precedes that of endocytosed proteins bearing the mannose 6-phosphate recognition marker.

C. Gabel, F. Maxfield, R. Einstein, 1990, The Journal of biological chemistry.

Identification of protein-bound oligosaccharides on the surface of growth cones that bind to muscle cells.

C. Gabel, R. Ambron, H. Den, 1989, Journal of neurobiology.

Characterization of protein-linked glycoconjugates produced by identified neurons of Aplysia californica.

C. Gabel, R. Ambron, H. Den, 1989, Journal of neurobiology.

Benzimidazolone p38 inhibitors.

C. Gabel, T. Carty, John T Barberia, 2004, Bioorganic & medicinal chemistry letters.

Deficiency of the Stress Kinase P38α Results in Embryonic Lethality

Melanie Allen, C. Gabel, J. Mcneish, 2000, The Journal of Experimental Medicine.

Introduction of Selectin-like Binding Specificity into a Homologous Mannose-binding Protein (*)

C. Gabel, K. Drickamer, O. Blanck, 1996, The Journal of Biological Chemistry.

Human monocyte ATP‐induced IL‐1β posttranslational processing is a dynamic process dependent on in vitro growth conditions

C. Gabel, D. Perregaux, R. Laliberte, 1997, Journal of leukocyte biology.

Discovery of a Series of Ester-substituted NLRP3 Inflammasome Inhibitors.

C. Gabel, R. Porter, J. Doedens, 2020, Bioorganic & medicinal chemistry letters.

Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption.

S. M. Sims, S. Dixon, V. Paralkar, 2003, Molecular endocrinology.

PS1-43 IL-1F ligands require processing for full agonist (IL-1f6, IL-1f8 and IL-1f9) or antagonist (IL-1f5) activity

C. Gabel, J. Sims, B. Lipsky, 2010 .

Human Monocyte Interleukin-1β Posttranslational Processing

C. Gabel, D. Perregaux, R. Laliberte, 1996, The Journal of Biological Chemistry.

Targeting of beta-glucuronidase to lysosomes in mannose 6-phosphate receptor-deficient MOPC 315 cells

C. Gabel, S. Kornfeld, 1984, The Journal of cell biology.

Bafilomycin A1 inhibits IL-1-stimulated proteoglycan degradation by chondrocytes without affecting stromelysin synthesis.

C. Gabel, A. Milici, L. Lopresti-Morrow, 1995, Archives of biochemistry and biophysics.

P2 purinergic receptor modulation of cytokine production

C. Gabel, 2007, Purinergic Signalling.

Glutathione s-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1beta posttranslational processing.

C. Gabel, K. Geoghegan, P. Rosner, 2003, The Journal of biological chemistry.

Receptor-mediated endocytosis and differential synthesis of mannose 6-phosphate receptors in isolated spermatogenic and sertoli cells.

D. A. O’Brien, C. Gabel, E. M. Eddy, 1989, Endocrinology.

Periodate Oxidized ATP (oATP) Reduces Hyperalgesia in Mice: Involvement of P2X7 Receptors and Implications for Therapy

C. Gabel, A. Quattrini, A. Fulgenzi, 2008, International journal of immunopathology and pharmacology.

Novel protein therapeutic joint retention strategy based on collagen‐binding Avimers

R. Black, C. Gabel, Richard Smith, 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Synovial fluid from rheumatoid arthritis patients contains sufficient levels of IL-1 beta and IL-6 to promote production of serum amyloid A by Hep3B cells.

C. Gabel, J. Sullivan, H. Showell, 1995, Cytokine.

Post-translational processing of murine IL-1: evidence that ATP-induced release of IL-1 alpha and IL-1 beta occurs via a similar mechanism.

C. Gabel, D. Perregaux, 1998, Journal of immunology.

1 INTERLEUKIN-36 ( IL-36 ) LIGANDS REQUIRE PROCESSING FOR FULL AGONIST ( IL-36 α , IL-36 β AND IL-36 γ ) OR ANTAGONIST ( IL-36 Ra ) ACTIVITY

C. Gabel, J. Sims, B. Lipsky, 2011 .