M. Senior

发表

Flexible lid to the p53-binding domain of human Mdm2: Implications for p53 regulation

M. McCoy, J. Gesell, M. Senior, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening.

M. McCoy, M. Senior, D. Wyss, 2004, Journal of medicinal chemistry.

Screening of protein kinases by ATP-STD NMR spectroscopy.

M. McCoy, M. Senior, D. Wyss, 2005, Journal of the American Chemical Society.

Discovery of a potent thiadiazole class of histamine h3 receptor antagonist for the treatment of diabetes.

M. Senior, A. Palani, B. Mckittrick, 2012, ACS medicinal chemistry letters.

Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia.

W. Greenlee, M. Senior, Xiaohong Zhu, 2012, ACS medicinal chemistry letters.

Using HMBC and ADEQUATE NMR data to define and differentiate long-range coupling pathways: is the Crews rule obsolete?

M. Senior, G. Martin, R. Williamson, 2013, Journal of natural products.

Importance of the loop connecting A and B helices of human interferon-gamma in recognition by interferon-gamma receptor.

M. Senior, S. Narula, C. Lunn, 1994, The Journal of biological chemistry.

Ras oncoprotein inhibitors: the discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex.

L. Perkins, S. Liberles, J. Brown, 1997, Bioorganic & medicinal chemistry.

NMR-based approaches for lead discovery.

M. Senior, D. Wyss, M. Mccoy, 2002, Current opinion in drug discovery & development.

Syntheses of 4- and 6-substituted thiazolo[4,5-c]pyridines

M. Senior, M. Maccoss, N. Bansal, 2010 .

Unambiguous structural characterization of hydantoin reaction products using 2D HMBC NMR spectroscopy

A. Stamford, M. Senior, Guoqing Li, 2007, Magnetic resonance in chemistry : MRC.

Chemical shift assignments and secondary structure of the Grb2 SH2 domain by heteronuclear NMR spectroscopy

L. Perkins, M. Senior, P. Kirschmeier, 1996, Journal of biomolecular NMR.

Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.

Zhuyan Guo, Frank Bennett, Rong-Sheng Yang, 2007, Journal of medicinal chemistry.

Solution structure and dynamics of the single-chain hepatitis C virus NS3 protease NS4A cofactor complex.

J. Gesell, M. Senior, D. Wyss, 2001, Journal of molecular biology.

The Three-Dimensional Solution Structure of the Src Homology Domain-2 of the Growth Factor Receptor-Bound Protein-2

L. Perkins, M. Snow, M. Senior, 1998, Journal of biomolecular NMR.

Development of a Receptor Peptide Antagonist to Human -Interferon and Characterization of Its Ligand-bound Conformation Using Transferred Nuclear Overhauser Effect Spectroscopy (*)

M. Senior, W. Prosise, J. Hawkins, 1995, The Journal of Biological Chemistry.

Concise syntheses and HCV NS5B polymerase inhibition of (2'R)-3 and (2'S)-2'-ethynyluridine-10 and related nucleosides.

M. Senior, A. Malikzay, P. Tawa, 2017, Bioorganic & Medicinal Chemistry Letters.

Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors.

Michael Czarniecki, John C Hunter, William J Greenlee, 2010, Journal of medicinal chemistry.

Solution conformation of endothelin and point mutants by nuclear magnetic resonance spectroscopy.

M. Senior, D. Dalgarno, S. Chackalamannil, 2009, International journal of peptide and protein research.

Influence of dangling thymidine residues on the stability and structure of two DNA duplexes.

Roger A. Jones, M. Senior, K. Breslauer, 1988, Biochemistry.

Discovery of the HCV NS3/4A Protease Inhibitor SCH503034. Key Steps in Structure-Based Optimization

P. Weber, M. Senior, Z. Hong, 2007 .