D. Macneil

发表

Variations in DNA elucidate molecular networks that cause disease

S. Horvath, Bin Zhang, Chunsheng Zhang, 2008, Nature.

Identification of Genes and Networks Driving Cardiovascular and Metabolic Phenotypes in a Mouse F2 Intercross

A. Kasarskis, Bin Zhang, C. Molony, 2010, PloS one.

Validation of Candidate Causal Genes for Abdominal Obesity Which Affect Shared Metabolic Pathways and Networks

Xia Yang, Eric E. Schadt, Joshua L. Deignan, 2009, Nature Genetics.

Regulation and characterization of protein products coded by the nif (nitrogen fixation) genes of Klebsiella pneumoniae

W. Brill, D. Macneil, G. Roberts, 1978, Journal of bacteriology.

Chronic administration of nalmefene leads to increased food intake and body weight gain in mice.

D. Macneil, Richard Z. Chen, T. Fong, 2004, European journal of pharmacology.

Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression.

C. Austin, D. Macneil, H. Iwaasa, 2002, Genomics.

Synthesis and biological evaluation in vitro of selective, high affinity peptide antagonists of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.

M. Bednarek, D. Macneil, L. V. D. van der Ploeg, 2002, Biochemistry.

Diet induction of monocyte chemoattractant protein-1 and its impact on obesity.

Chunsheng Zhang, J. Lamb, H. Dai, 2005, Obesity research.

Characterization of a unique methyl-specific restriction system in Streptomyces avermitilis

D. Macneil, Exploratory, 1988, Journal of bacteriology.

Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice.

N. Morin, D. Macneil, Y. Saga, 2000, Endocrinology.

L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist.

D. Macneil, H. Iwaasa, L. V. D. van der Ploeg, 2000, Biochemical and biophysical research communications.

Pancreatic polypeptide enhances colonic muscle contraction and fecal output through neuropeptide Y Y4 receptor in mice.

D. Macneil, A. Kanatani, J. Suzuki, 2010, European journal of pharmacology.

Peripheral and central administration of a selective neuropeptide Y Y1 receptor antagonist suppresses ethanol intake by C57BL/6J mice.

D. R. Sparta, D. Macneil, T. E. Thiele, 2004, Alcoholism, clinical and experimental research.

NPY-induced feeding involves the action of a Y1-like receptor in rodents

D. Macneil, H. Iwaasa, A. Kanatani, 1998, Regulatory Peptides.

Transformation ofStreptomyces avermitilis by plasmid DNA

D. Macneil, Linda M. Klapko, Linda M. Klapko, 1987, Journal of Industrial Microbiology.

Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents.

D. Macneil, J. Metzger, D. Macintyre, 2008, European journal of pharmacology.

Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults.

S. Heymsfield, D. Macneil, Haiyuan Zhu, 2007, The Journal of clinical endocrinology and metabolism.

Neuropeptide Y receptors as targets of obesity treatment

D. Macneil, A. Kanatani, T. Fukami, 2006 .

Design and synthesis of (ant)-agonists that alter appetite and adiposity.

D. Macneil, L. V. D. van der Ploeg, R. Nargund, 2006, Progress in brain research.

Antagonism of central melanin-concentrating hormone 1 receptor alleviates steatohepatitis in mice.

M. Bednarek, D. Macneil, H. Iwaasa, 2008, The Journal of endocrinology.

Blockade of MCH1 receptor signalling ameliorates obesity and related hepatic steatosis in ovariectomized mice

M. Bednarek, D. Macneil, H. Iwaasa, 2007, British journal of pharmacology.

Increased melanin concentrating hormone receptor type I in the human hypothalamic infundibular nucleus in cachexia.

D. Swaab, D. Macneil, L. V. D. van der Ploeg, 2005, The Journal of clinical endocrinology and metabolism.

Cloning and expression of a human glucagon receptor.

C. Strader, D. Macneil, M. Graziano, 1994, Biochemical and biophysical research communications.

Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice: chronic intracerebroventricular infusion of D-Trp(34)NPY.

N. Morin, D. Macneil, H. Iwaasa, 2003, Endocrinology.

Isolation and characterization of lambda specialized transducing bacteriophages carrying Klebsiella pneumoniae nif genes

W. Brill, D. Macneil, M. Howe, 1980, Journal of bacteriology.

Characterization ofa UniqueMethyl-Specific Restriction System inStreptomyces avermitilis

D. Macneil, 1988 .

Vectors for generating nested deletions and facilitating subcloning G+C-rich DNA between Escherichia coli and Streptomyces sp.

D. Macneil, F. Foor, J. Occi, 1992, Gene.

The mγδ-1 element, a small γδ (Tn1000) derivative useful for plasmid mutagenesis, allele replacement and DNA sequencing

D. Macneil, D. Berg, Xiaoxin Xu, 1992 .

Fine-structure mapping and complementation analysis of nif (nitrogen fixation) genes in Klebsiella pneumoniae

W. Brill, D. Macneil, G. Roberts, 1978, Journal of bacteriology.

Effects of a Novel Y5 Antagonist in Obese Mice: Combination With Food Restriction or Sibutramine

D. Macneil, H. Iwaasa, H. Matsushita, 2008, Obesity.

Regulation of nitrogen fixation in Klebsiella pneumoniae: isolation and characterization of strains with nif-lac fusions

W. Brill, D. Macneil, Winston, 1981, Journal of bacteriology.

Mutations in nif genes that cause Klebsiella pneumoniae to be derepressed for nitrogenase synthesis in the presence of ammonium

W. Brill, D. Macneil, 1980, Journal of bacteriology.

6-cyanopurine, a color indicator useful for isolating mutations in the nif (nitrogen fixation) genes of Klebsiella pneumoniae

W. Brill, D. Macneil, 1978, Journal of bacteriology.

Homology-based cloning methods. Identification of the NPY Y2, Y4, and Y6 receptors.

D. Macneil, D. Weinberg, 2000, Methods in molecular biology.

Detailed pharmacological characterization of GT-2331 for the rat histamine H3 receptor.

D. Macneil, R. Yoshimoto, Takao Nakamura, 2006, European journal of pharmacology.

Synergistic effects of cannabinoid inverse agonist AM251 and opioid antagonist nalmefene on food intake in mice

D. Macneil, Richard Z. Chen, T. Fong, 2004, Brain Research.

Role of the Escherichia coli glnALG operon in regulation of ammonium transport

D. Macneil, E. M. Barnes, A. Jayakumar, 1986, Journal of bacteriology.

Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.

M. Reitman, D. Macneil, S. Qian, 2011, Bioorganic & medicinal chemistry letters.

2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity.

M. Reitman, D. Macneil, R. Berger, 2008, Bioorganic & medicinal chemistry letters.

Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults.

Bengt Långström, Sandra M. Sanabria-Bohórquez, Steven B Heymsfield, 2006, Cell metabolism.

A Pair-Feeding Study Reveals That a Y5 Antagonist Causes Weight Loss in Diet-Induced Obese Mice by Modulating Food Intake and Energy Expenditure

D. Macneil, H. Iwaasa, L. V. D. van der Ploeg, 2007, Molecular Pharmacology.

A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice.

D. Macneil, H. Iwaasa, L. V. D. van der Ploeg, 2006, Proceedings of the National Academy of Sciences of the United States of America.

[Development of anorectic NPY antagonists: possible roles of Y1 and Y5 receptors in feeding regulation].

D. Macneil, H. Iwaasa, A. Kanatani, 2006, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Synthesis and Biological Evaluation in Vitro of a Selective, High Potency Peptide Agonist of Human Melanin-concentrating Hormone Action at Human Melanin-concentrating Hormone Receptor 1*

M. Bednarek, D. Macneil, L. V. D. van der Ploeg, 2002, The Journal of Biological Chemistry.

Fine-structure deletion map and complementation analysis of the glnA-glnL-glnG region in Escherichia coli

D. Macneil, T. Macneil, B. Tyler, 1982, Journal of bacteriology.

Expression, refolding, and purification of recombinant human phosphodiesterase 3B: definition of the N-terminus of the catalytic core.

M. Tota, N. Morin, D. Macneil, 2004, Protein expression and purification.

General method, using Mu-Mud1 dilysogens, to determine the direction of transcription of and generate deletions in the glnA region of Escherichia coli

D. Macneil, 1981, Journal of bacteriology.

MCH receptor peptide agonists and antagonists

M. Bednarek, D. Macneil, 2009, Peptides.

Molecular analysis of a new splice variant of the human melanocortin‐1 receptor

D. Macneil, L. V. D. van der Ploeg, A. Howard, 1999, FEBS letters.

Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity.

M. Tota, M. Reitman, D. Macneil, 2008, Basic & clinical pharmacology & toxicology.

Liver and Adipose Expression Associated SNPs Are Enriched for Association to Type 2 Diabetes

Xia Yang, Eric E. Schadt, Lee M. Kaplan, 2010, PLoS genetics.

Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector.

D. Macneil, T. Macneil, C. Ruby, 1992, Gene.

A flexible boiling procedure for isolating plasmid DNA from gram-positive microorganisms

D. Macneil, 1986 .

Genetic Modifications of N2-Fixing Systems

W. Brill, D. Macneil, T. Macneil, 1978 .

GPR133 (ADGRD1), an adhesion G-protein-coupled receptor, is necessary for glioblastoma growth

A. Heguy, J. Golfinos, M. Snuderl, 2016, Oncogenesis.

Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice

D. Macneil, S. Qian, L. V. D. van der Ploeg, 2002, Molecular and Cellular Biology.

Expression profiling of the adhesion G protein-coupled receptor GPR133 (ADGRD1) in glioma subtypes

James X. Sun, T. Schöneberg, R. Jain, 2020, Neuro-oncology advances.

Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans.

D. Macneil, C. Hutchinson, K. Kulowski, 2001, Chemistry & biology.

Production of the antitumor drug epirubicin (4′-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius

D. Macneil, J. Kennedy, K. Madduri, 1998, Nature Biotechnology.

Introduction of plasmid DNA into Streptomyces lividans by electroporation

D. Macneil, 1987 .

NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs.

D. Macneil, 2007, Current topics in medicinal chemistry.

Cloning and Expression of a Novel Neuropeptide Y Receptor*

C. Strader, N. Morin, D. Macneil, 1996, The Journal of Biological Chemistry.

Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus

D. Macneil, R. Yoshimoto, H. Kotani, 2006, Proceedings of the National Academy of Sciences.

Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R

Christopher P. Austin, Masahiko Ito, Alka Bansal, 2001, Proceedings of the National Academy of Sciences of the United States of America.

The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.

M. Tota, M. Bednarek, D. Macneil, 2002, European journal of pharmacology.

Distribution of orexin receptor mRNA in the rat brain

D. Macneil, L. V. D. van der Ploeg, X M Guan, 1998, FEBS letters.

Silencing of Cytosolic or Mitochondrial Isoforms of Malic Enzyme Has No Effect on Glucose-stimulated Insulin Secretion from Rodent Islets*

D. Macneil, M. Jensen, O. Ilkayeva, 2008, Journal of Biological Chemistry.

Receptor for motilin identified in the human gastrointestinal system.

Jilly F. Evans, Ploeg, C. Austin, 1999, Science.

Order of genes near nif in Klebsiella pneumoniae

W. Brill, D. Macneil, M. Supiano, 1979, Journal of bacteriology.

The Role of Melanin-Concentrating Hormone and Its Receptors in Energy Homeostasis

Douglas J. MacNeil, D. Macneil, 2013, Front. Endocrinol..

Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism

Yue Feng, D. Macneil, J. Metzger, 2002, Proceedings of the National Academy of Sciences of the United States of America.

4-Aminoquinoline melanin-concentrating hormone 1-receptor (MCH1R) antagonists.

N. Morin, D. Macneil, R. DeVita, 2006, Bioorganic & medicinal chemistry letters.

2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists.

Ramon Camacho, D. Macneil, R. DeVita, 2006, Bioorganic & medicinal chemistry letters.

Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice.

M. Bednarek, D. Macneil, H. Iwaasa, 2005, Endocrinology.

Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists.

D. Macneil, H. Iwaasa, A. Kanatani, 2009, Bioorganic & Medicinal Chemistry Letters.

NPY and energy homeostasis: an opportunity for novel anti-obesity therapies.

D. Macneil, A. Kanatani, 2006, EXS.

The role of tryptophan 1072 in human PDE3B inhibitor binding.

M. Tota, N. Morin, D. Macneil, 2003, Biochemical and biophysical research communications.

Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase.

D. Macneil, T. Macneil, J. Occi, 1992, Gene.

A miniaturized homogenous assay of mitochondrial membrane potential.

D. Macneil, C. Rosenblum, L. Kiss, 2011, Assay and drug development technologies.

Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein.

D. Macneil, Roy G. Smith, S. Qian, 2004, Endocrinology.

Isolation and Characterization of Antisuppressor Mutations in Escherichia coli

J. Miller, W. Reznikoff, D. Macneil, 2022 .

EFFECTS OF 12 WEEKS OF EXERCISE TRAINING ON PLASMA LIPIDS AND APOLIPOPROTEINS (APOS) IN MIDDLE-AGED MEN

D. Macneil, P. Alaupovic, W. Mcconathy, 1982 .

In vivo optical imaging of LacZ expression using lacZ transgenic mice.

B. Connolly, D. Macneil, R. Hargreaves, 2009, Assay and drug development technologies.

Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice.

D. Macneil, H. Iwaasa, H. Matsushita, 2009, European journal of pharmacology.

Correlation of the Avermectin Polyketide Synthase Genes to the Avermectin Structure: Implications for Designing Novel Avermectins

D. Macneil, T. Macneil, J. Occi, 1994, Annals of the New York Academy of Sciences.

Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.

M. Struthers, D. Macneil, D. Cully, 2017, Bioorganic & medicinal chemistry letters.

Deletion analysis of the avermectin biosynthetic genes of Streptomyces avermitilis by gene cluster displacement

D. Macneil, T. Macneil, K. Gewain, 1993, Journal of bacteriology.

Novel sesquiterpenoids from the fermentation of Xylaria persicaria are selective ligands for the NPY Y5 receptor.

Scott K. Smith, N. Morin, D. Macneil, 2002, The Journal of organic chemistry.

CHAPTER 15 – Avermectins

D. Macneil, 1995 .

Regulation of nitrogen fixation in Klebsiella pneumoniae: isolation and characterization of strains with nif-lac fusions

D. Macneil, Winston, J. Brill, 1981 .

Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension.

M. Struthers, D. Macneil, D. Cully, 2017, ACS medicinal chemistry letters.

Terminal redundancy heterozygotes involving the first-step-transfer region of the bacteriophage T5 chromosome.

N. Kleckner, D. Macneil, D. Fischhoff, 1976, Genetics.

Discovery of imidazole carboxamides as potent and selective CCK1R agonists.

M. Reitman, D. Macneil, S. Qian, 2008, Bioorganic & medicinal chemistry letters.

The products of glnL and glnG are bifunctional regulatory proteins

D. Macneil, G. Roberts, T. Macneil, 2004, Molecular and General Genetics MGG.

Effects of a Novel Y5 Antagonist in Obese Mice: Combination With Food Restriction

D. Macneil, A. Kanatani, T. Fukami, 2008 .

Antagonism of central melanin-concentrating hormone 1 receptor alleviates steatohepatitis in mice.

M. Bednarek, D. Macneil, H. Iwaasa, 2008, The Journal of endocrinology.

Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus

D. Macneil, R. Yoshimoto, H. Kotani, 2006, Proceedings of the National Academy of Sciences.

regulation of ammonium transport. Role of the Escherichia coli glnALG operon in

D. Macneil, E. M. Barnes, A. Jayakumar, 2013 .

Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice.

M. Bednarek, D. Macneil, H. Iwaasa, 2005, Endocrinology.

2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity.

M. Reitman, D. Macneil, R. Berger, 2008, Bioorganic & medicinal chemistry letters.

Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.

M. Reitman, D. Macneil, S. Qian, 2011, Bioorganic & Medicinal Chemistry Letters.

Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2.

D. Macneil, S. Feighner, D. Hreniuk, 2001, Biochemistry.