S. Sligar

发表

Molecular recognition in the p450cam monooxygenase system: direct monitoring of protein-protein interactions by using optical biosensor.

Y. Ivanov, I. P. Kanaeva, I. Karuzina, 2001, Archives of biochemistry and biophysics.

The energy landscapes and motions of proteins.

P. Wolynes, H. Frauenfelder, S. Sligar, 1991, Science.

Trimerization of the HIV Transmembrane Domain in Lipid Bilayers Modulates Broadly Neutralizing Antibody Binding.

S. Sligar, P. Dawson, T. Reichart, 2016, Angewandte Chemie.

Small-angle scattering determination of the shape and localization of human cytochrome P450 embedded in a phospholipid nanodisc environment.

S. Sligar, S. Kynde, L. Arleth, 2015, Acta crystallographica. Section D, Biological crystallography.

Self-Assembly of Discoidal Phospholipid Bilayer Nanoparticles with Membrane Scaffold Proteins

Stephen G. Sligar, S. Sligar, T. H. Bayburt, 2002 .

Self‐assembly of single integral membrane proteins into soluble nanoscale phospholipid bilayers

S. Sligar, T. H. Bayburt, Stephen G Sligar, 2003, Protein science : a publication of the Protein Society.

Homotropic cooperativity of monomeric cytochrome P450 3A4 in a nanoscale native bilayer environment.

S. Sligar, I. Denisov, B. Baas, 2004, Archives of biochemistry and biophysics.

Molecular dynamics simulations of discoidal bilayers assembled from truncated human lipoproteins.

Klaus Schulten, James C. Phillips, James C Phillips, 2005, Biophysical journal.

Assembly of single bacteriorhodopsin trimers in bilayer nanodiscs.

S. Sligar, T. H. Bayburt, Y. Grinkova, 2006, Archives of biochemistry and biophysics.

Chapter 11 - Reconstitution of membrane proteins in phospholipid bilayer nanodiscs.

S. Sligar, I. Denisov, T. H. Bayburt, 2009, Methods in enzymology.

Elliptical structure of phospholipid bilayer nanodiscs encapsulated by scaffold proteins: casting the roles of the lipids and the protein.

Lise Arleth, Robert Feidenhans'l, Kell Mortensen, 2010, Journal of the American Chemical Society.

Mechanism of drug-drug interactions mediated by human cytochrome P450 CYP3A4 monomer.

Emad Tajkhorshid, Javier L Baylon, E. Tajkhorshid, 2015, Biochemistry.

Two copies of the SecY channel and acidic lipids are necessary to activate the SecA translocation ATPase

S. Sligar, F. Duong, Kush Dalal, 2012, Proceedings of the National Academy of Sciences.

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

Taekjip Ha, Maddy Parsons, Brenton D. Hoffman, 2010, Nature.

Anomalous transitions of DODAB using fast scanning liquid calorimetry

P. Nealey, S. Sligar, Liang Hu, 2011 .

Single-molecule height measurements on microsomal cytochrome P450 in nanometer-scale phospholipid bilayer disks

S. Sligar, T. H. Bayburt, Stephen G Sligar, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Finding a single-molecule solution for membrane proteins.

S. Sligar, Stephen G Sligar, 2003, Biochemical and biophysical research communications.

Co-incorporation of heterologously expressed Arabidopsis cytochrome P450 and P450 reductase into soluble nanoscale lipid bilayers.

S. Sligar, M. Schuler, H. Duan, 2004, Archives of biochemistry and biophysics.

Analysis of the kinetic barriers for ligand binding to sperm whale myoglobin using site-directed mutagenesis and laser photolysis techniques.

S. Sligar, Q. Gibson, J. Olson, 1990, The Journal of biological chemistry.

Applications of phospholipid bilayer nanodiscs in the study of membranes and membrane proteins.

S. Sligar, W. Atkins, A. Nath, 2007, Biochemistry.

Correlation between the steric bulk of the distal E7 and E11 residues and the tilt of the FeCN unit in cyanometmyoglobin as determined by NMR from the orientation of the magnetic axes in single and double point mutants.

S. Sligar, M. Chiu, K. Rajarathnam, 1994, Biochemistry.

Solution structure determination of the heme cavity in the E7 His-->Val cyano-met myoglobin point mutant based on the 1H NMR detected dipolar field of the iron: evidence for contraction of the heme pocket.

S. Sligar, M. Chiu, K. Rajarathnam, 1993, Biochemistry.

The role of the distal histidine in myoglobin and haemoglobin

Jean-Paul Renaud, Stephen G. Sligar, Barry A. Springer, 1988, Nature.

Nanomechanical detection of cholera toxin using microcantilevers functionalized with ganglioside nanodiscs

Soo-Hyun Tark, Vinayak P Dravid, A. Das, 2010, Nanotechnology.

Recreation of the terminal events in physiological integrin activation

S. Sligar, K. Taylor, A. Bobkov, 2010, The Journal of cell biology.

Magic-angle spinning solid-state NMR spectroscopy of nanodisc-embedded human CYP3A4.

C. Rienstra, S. Sligar, Ying Li, 2007, Biochemistry.

Cysteine-specific surface tethering of genetically engineered cytochromes for fabrication of metalloprotein nanostructures

Paul W. Bohn, Stephen G. Sligar, Min Jiang, 1994 .

Oxidase uncoupling in heme monooxygenases: human cytochrome P450 CYP3A4 in Nanodiscs.

S. Sligar, I. Denisov, Y. Grinkova, 2013, Biochemical and biophysical research communications.

Dark, Ultra-Dark and Ultra-Bright Nanodiscs for membrane protein investigations.

S. Sligar, I. Denisov, Y. Grinkova, 2020, Analytical biochemistry.

Nanodiscs as a Modular Platform for Multimodal MR-Optical Imaging.

T. Meade, S. Sligar, K. Macrenaris, 2015, Bioconjugate chemistry.

Application of Fragment-Based Drug Discovery to Membrane Proteins: Identification of Ligands of the Integral Membrane Enzyme DsbB

Gregg Siegal, Eiso Ab, G. Siegal, 2015 .

Nanodiscs: A toolkit for membrane protein science

S. Sligar, I. Denisov, 2020, Protein science : a publication of the Protein Society.

Investigations of heme ligation and ligand switching in cytochromes p450 and p420.

Yuhan Sun, S. Sligar, Jing Du, 2013, Biochemistry.

PIP2 Influences the Conformational Dynamics of Membrane bound KRAS4b

S. Sligar, A. Stephen, M. McLean, 2019, bioRxiv.

Phosphatidylinositol 4,5-Bisphosphate Modulates the Affinity of Talin-1 for Phospholipid Bilayers and Activates Its Autoinhibited Form.

S. Sligar, Xin Ye, M. McLean, 2016, Biochemistry.

Nanoscale Membrane Mimetics for Biophysical Studies of Membrane Proteins

S. Sligar, I. Denisov, Catherine J Baker, 2014 .

Interpretation and Deconvolution of Nanodisc Native Mass Spectra

M. Gross, S. Sligar, Hao Zhang, 2014, Journal of The American Society for Mass Spectrometry.

Nanodiscs in the studies of membrane-bound cytochrome P450 enzymes.

Michael C. Gregory, S. Sligar, I. Denisov, 2013, Methods in molecular biology.

Reconstitution of respiratory oxidases in membrane nanodiscs for investigation of proton‐coupled electron transfer

R. Gennis, S. Sligar, P. Brzezinski, 2012, FEBS letters.

Native mass spectrometry characterization of intact nanodisc lipoprotein complexes.

M. Gross, S. Sligar, Hao Zhang, 2012, Analytical chemistry.

Temperature derivative spectroscopy to monitor the autoxidation decay of cytochromes P450.

S. Sligar, I. Denisov, A. Luthra, 2011, Analytical chemistry.

High-level expression of sperm whale myoglobin in Escherichia coli.

S. Sligar, B. Springer, 1987, Proceedings of the National Academy of Sciences of the United States of America.

1H NMR Hyperfine Shift Pattern as a Probe for Ligation State in High-Spin Ferric Hemoproteins: Water Binding in Metmyoglobin Mutants

Kevin M. Smith, Kevin M Smith, S. Sligar, 1991 .

Structural microheterogeneity of a tryptophan residue required for efficient biological electron transfer between putidaredoxin and cytochrome P-450cam.

S. Sligar, P. Stayton, 1991, Biochemistry.

Nanodiscs unravel the interaction between the SecYEG channel and its cytosolic partner SecA

S. Sligar, F. Duong, Kush Dalal, 2007, The EMBO journal.

Synthesis, bacterial expression, and mutagenesis of the gene coding for mammalian cytochrome b5.

S. Sligar, M. Schuler, S. Beck von Bodman, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Twenty-five Years of P450cam Research

S. Sligar, E. Mueller, P. Loida, 1995 .

Genetic engineering of surface attachment sites yields oriented protein monolayers

S. Sligar, P. Stayton, P. Bohn, 1992 .

Evidence for a homolytic mechanism of peroxide oxygen--oxygen bond cleavage during substrate hydroxylation by cytochrome P-450.

M. J. Coon, S. Sligar, R. E. White, 1980, The Journal of biological chemistry.

Multiple mechanisms of cytochrome P450-catalyzed substrate hydroxylations.

S. Sligar, D. Heimbrook, 1981, Biochemical and biophysical research communications.

Demethylation of N,N-dimethylaniline and p-cyano-N,N-dimethylaniline and their N-oxides by cytochromes P450LM2 and P450CAM

S. Sligar, T. C. Bruice, D. Heimbrook, 1984 .

Stereochemistry and deuterium isotope effects in camphor hydroxylation by the cytochrome P450cam monoxygenase system.

M. Gelb, S. Sligar, D. Heimbrook, 1982, Biochemistry.

Cytochrome P-450cam and Other Bacterial P-450 Enzymes

S. Sligar, R. Murray, 1986 .

Bio-organic chemistry and cytochrome P-450-dependent catalysis.

M. Gelb, S. Sligar, D. Heimbrook, 1984, Xenobiotica; the fate of foreign compounds in biological systems.

Interaction of 5-bromocamphor with cytochrome P-450 cam. Production of 5-ketocamphor from a mixed spin state hemoprotein.

M. Gelb, S. Sligar, P. Gould, 1981, The Journal of biological chemistry.

Resonance raman investigations of site-directed mutants of myoglobin: effects of distal histidine replacement.

S. Sligar, D. Morikis, P. Champion, 1989, Biochemistry.

The effects of amino acid substitution at position E7 (residue 64) on the kinetics of ligand binding to sperm whale myoglobin.

S. Sligar, J. Olson, T. Carver, 1990, The Journal of biological chemistry.

Thermophilic cytochrome P450 (CYP119) from Sulfolobus solfataricus: high resolution structure and functional properties.

Yoshitsugu Shiro, Shin-ichi Adachi, S. Sligar, 2002, Journal of inorganic biochemistry.

1H NMR study of the influence of hydrophobic contacts on protein-prosthetic group recognition in bovine and rat ferricytochrome b5.

S. Sligar, G. L. La Mar, T. Pochapsky, 1990, Biochemistry.

Relationship between heme binding site structure and heme orientations of two ferrocytochrome b5s. A study in prosthetic group recognition

S. Sligar, T. Pochapsky, G. N. Mar, 1990 .

Spectroscopic features of cytochrome P450 reaction intermediates.

S. Sligar, I. Denisov, A. Luthra, 2011, Archives of biochemistry and biophysics.

Kinetic solvent isotope effects during oxygen activation by cytochrome P-450cam

S. Sligar, J. Aikens, 1994 .

Resonance Raman and EPR investigations of the D251N oxycytochrome P450cam/putidaredoxin complex.

S. Sligar, B. Hoffman, P. Champion, 2001, Biochemistry.

Resonance Raman investigations of cytochrome P450(cam) complexed with putidaredoxin

D. E. Benson, S. Sligar, P. Champion, 1997 .

Hydrogen-bonding interactions in the active sites of cytochrome P450cam and its site-directed mutants.

S. Sligar, T. Deng, M. Sykora, 2001, Journal of the American Chemical Society.

The ferrous-oxy complex of human aromatase.

M. Waterman, N. Kagawa, S. Sligar, 2008, Biochemical and biophysical research communications.

Site-directed mutagenesis of histidine residues involved in Cu(II) binding and reduction by sperm whale myoglobin.

S. Sligar, D. Bakan, B. Springer, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Tyrosine motions in relation to the ferric spin equilibrium of cytochrome P-450cam.

S. Sligar, M. Fisher, 1985, Biochemistry.

Tyrosine-96 as a natural spectroscopic probe of the cytochrome P-450cam active site.

S. Sligar, W. Atkins, 1990, Biochemistry.

Determination of cytochrome b5 association reactions. Characterization of metmyoglobin and cytochrome P-450cam binding to genetically engineered cytochromeb5.

S. Sligar, P. Stayton, M. Fisher, 1988, The Journal of biological chemistry.

Structural studies of cytochrome P-450 using small angle x-ray scattering.

S. Sligar, B. Lewis, 1983, The Journal of biological chemistry.

Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala.

S. Martinis, R. Raag, T. Poulos, 1991, Biochemistry.

Active site proton delivery and the lyase activity of human CYP17A1.

Michael C. Gregory, S. Sligar, I. Denisov, 2014, Biochemical and Biophysical Research Communications - BBRC.

Resonance Raman spectroscopy reveals that substrate structure selectively impacts the heme-bound diatomic ligands of CYP17.

Michael C. Gregory, S. Sligar, J. Kincaid, 2014, Biochemistry.

Temperature jump relaxation kinetics of the P-450cam spin equilibrium.

S. Sligar, M. Fisher, 1987, Biochemistry.

Thermodynamic properties of oxidation-reduction reactions of bacterial, microsomal, and mitochondrial cytochromes P-450: an entropy-enthalpy compensation effect.

M. J. Coon, S. Sligar, T. Kimura, 1986, Biochemistry.

Midazolam as a Probe for Heterotropic Drug-Drug Interactions Mediated by CYP3A4

S. Sligar, I. Denisov, Y. Grinkova, 2022, Biomolecules.

Macromolecular Hydration Changes Associated withBamHI Binding and Catalysis*

S. Sligar, T. W. Lynch, 2000, Journal of Biological Chemistry.

Carbon monoxide binding to cytochrome P450BM-3: evidence for a substrate-dependent conformational change.

S. Sligar, M. McLean, H. Yeom, 1996, Biochimie.

Molecular Recognition in Cytochrome P-450: Alteration of Regioselective Alkane Hydroxylation via Protein Engineering.

S. Sligar, W. Atkins, 1989 .

Purification and Characterization of Microsomal Cytochrome b(5) and NADH Cytochrome b(5) Reductase from Pisum sativum.

S. Sligar, M. Schuler, D. Jollie, 1987, Plant physiology.

Electron Transfer between Cytochrome B5 Surface Mutants and Cytochrome C

S. Sligar, L. Qin, K. Rodgers, 1991 .

Electron transfer from cytochromeb5 to cytochromec

Jill R. Scott, S. Sligar, B. Durham, 1995, Journal of bioenergetics and biomembranes.

Engineering cytochrome P-450cam to increase the stereospecificity and coupling of aliphatic hydroxylation.

S. Sligar, P. Loida, 1993, Protein engineering.

Catalytic mechanism of cytochrome P-450: evidence for a distal charge relay

S. Sligar, N. Gerber, 1992 .

Effect of binding cytochrome c and ionic strength on the reorganizational energy and intramolecular electron transfer in cytochrome b5 labeled with ruthenium(II) polypyridine complexes

Jill R. Scott, S. Sligar, B. Durham, 1994 .

Intramolecular electron transfer in cytochrome b5 labeled with ruthenium(II) polypyridine complexes : rate measurements in the Marcus inverted region

Jill R. Scott, S. Sligar, P. Stayton, 1993 .

Intracomplex electron transfer between ruthenium-65-cytochrome b5 and position-82 variants of yeast iso-1-cytochrome c.

S. Sligar, G. Pielak, B. Durham, 1993, Biochemistry.

Cytochrome P-450 reduction exhibits burst kinetics.

S. Sligar, J. Schenkman, W. Backes, 1980, Biochemical and biophysical research communications.

Antibody targeted PET Imaging of 64Cu-DOTA-Anti-CEA PEGylated Lipid Nanodiscs in CEA positive tumors.

S. Sligar, J. Wong, P. Wong, 2020, Bioconjugate chemistry.

Cryoradiolysis and cryospectroscopy for studies of heme-oxygen intermediates in cytochromes p450.

S. Sligar, I. Denisov, Y. Grinkova, 2012, Methods in molecular biology.

Glimpsing the Critical Intermediate in Cytochrome P450 Oxidations

S. Sligar, 2010, Science.

Low-frequency dynamics of Caldariomyces fumago chloroperoxidase probed by femtosecond coherence spectroscopy.

T. Poulos, A. Das, S. Sligar, 2008, Biochemistry.

Cryoradiolytic reduction of heme proteins: Maximizing dose dependent yield.

S. Sligar, I. Denisov, Doreen C Victoria, 2007, Radiation physics and chemistry.

Thirty years of microbial P450 monooxygenase research: peroxo-heme intermediates--the central bus station in heme oxygenase catalysis.

S. Sligar, I. Denisov, T. Makris, 2005, Biochemical and biophysical research communications.

Tyrosine Radical Formation in the Reaction of Wild Type and Mutant Cytochrome P450cam with Peroxy Acids

S. Sligar, A. Barra, V. Schünemann, 2004, Journal of Biological Chemistry.

Cryoradiolysis for the study of P450 reaction intermediates.

S. Sligar, I. Denisov, T. Makris, 2002, Methods in enzymology.

MECHANISTIC ENZYMOLOGY OF OXYGEN ACTIVATION BY THE CYTOCHROMES P450

S. Sligar, B. Hoffman, I. Denisov, 2002, Drug metabolism reviews.

Cryogenic absorption spectra of hydroperoxo‐ferric heme oxygenase, the active intermediate of enzymatic heme oxygenation

S. Sligar, M. Ikeda-Saito, I. Denisov, 2002, FEBS letters.

Heme and oxygen: intermediates on the pathway to substrate oxygenation

S. Sligar, 2002 .

Cryotrapped Reaction Intermediates of Cytochrome P450 Studied by Radiolytic Reduction with Phosphorus-32*

S. Sligar, I. Denisov, T. Makris, 2001, The Journal of Biological Chemistry.

PIP2 Modulates the Affinity of Talin-1 for Phospholipid Bilayers and Activates its Auto-Inhibited Form

S. Sligar, Xin Ye, M. McLean, 2018 .

Conformational equilibrium of talin is regulated by anionic lipids.

S. Sligar, Xin Ye, M. McLean, 2016, Biochimica et biophysica acta.

Conformational equilibria of light-activated rhodopsin in nanodiscs

S. Sligar, W. Hubbell, M. Szczepek, 2017, Proceedings of the National Academy of Sciences.

Redox potential control by drug binding to cytochrome P450 3A4.

A. Das, S. Sligar, Y. Grinkova, 2007, Journal of the American Chemical Society.

20 – From Stars to Organic Chemistry via Cytochrome P450*

S. Sligar, 1982 .

Temperature‐jump measurement of the spin state relaxation rate of cytochrome P450cam

S. Sligar, P. E. Cole, 1981, FEBS letters.

OXYGEN REACTIONS OF THE P450 HEME PROTEIN

S. Sligar, B. Shastry, I. C. Gunsalus, 1977 .

1H NMR investigation of distal mutant deoxy myoglobins. Interpretation of proximal His contact shifts in terms of a localized distal water molecule.

S. Sligar, M. Chiu, M. Ikeda-Saito, 1994, The Journal of biological chemistry.

The role of Val68(E11) in ligand binding to sperm whale myoglobin. Site-directed mutagenesis of a synthetic gene.

S. Sligar, J. Olson, T. Carver, 1990, The Journal of biological chemistry.

Discrimination between oxygen and carbon monoxide and inhibition of autooxidation by myoglobin. Site-directed mutagenesis of the distal histidine.

S. Sligar, J. Olson, A. Mathews, 1989, The Journal of biological chemistry.

Nanodiscs for immobilization of lipid bilayers and membrane receptors: kinetic analysis of cholera toxin binding to a glycolipid receptor.

S. Sligar, P. Roepstorff, F. Torta, 2008, Analytical chemistry.

Drug-Drug Interactions between Atorvastatin and Dronedarone Mediated by Monomeric CYP3A4.

E. Tajkhorshid, S. Sligar, I. Denisov, 2017, Biochemistry.

Structural differences between soluble and membrane bound cytochrome P450s.

S. Sligar, I. Denisov, A. Shih, 2012, Journal of inorganic biochemistry.

Cytochrome P450 and Aromatic Bases: A 1H NMR Study

S. Sligar, I. Bertini, R. Pierattelli, 1994 .

Molecular recognition mediated by bound water. A mechanism for star activity of the restriction endonuclease EcoRI.

S. Sligar, S. Sligar, C. R. Robinson, 1993, Journal of molecular biology.

Haem-oxygen reactive intermediates: catalysis by the two-step.

S. Sligar, I. Denisov, T. Makris, 2003, Biochemical Society transactions.

Cytochrome P 450 enzymes : understanding the biochemical hieroglyphs

S. Benkovic, S. Sligar, 2019 .

Cytochrome P 450 enzymes : understanding the biochemical

S. Benkovic, S. Sligar, 2018 .

Cytochrome P450 enzymes: understanding the biochemical hieroglyphs (version 1; referees: 3 approved)

S. Sligar, J. Groves, P. R. Montellano, 2015 .

Cytochrome p450 compound I.

S. Sligar, S. Sligar, Rui Zhang, 2006, Journal of the American Chemical Society.

The acidic molten globule state of α-lactalbumin probed by sound velocity

S. Sligar, B. Nolting, Min Jiang, 1993 .

ENDOR determination of heme ligation in chloroperoxidase and comparison with cytochrome P-450Cam

S. Sligar, P. Osmulski, B. Hoffman, 1994 .

Resonance Raman detection of the hydroperoxo intermediate in the cytochrome P450 enzymatic cycle.

S. Sligar, I. Denisov, J. Kincaid, 2007, Journal of the American Chemical Society.

Protein electrochemistry at high pressure

Maria T. Cruañes, S. Sligar, K. Rodgers, 1992 .

Cytochrome P450cam catalyzed epoxidation of dehydrocamphor.

M. Gelb, S. Sligar, P. Malkonen, 1982, Biochemical and biophysical research communications.

Influence of Transmembrane Helix Mutations on Cytochrome P450-Membrane Interactions and Function

Neil J. Bruce, Michael C. Gregory, R. Wade, 2019, Biophysical journal.

Erratum: Stereochemistry and deuterium isotope effects in camphor hydroxylation by the cytochrome P450cam monoxygenase system (Biochemistry (1982) 21, 2, (370-377))

M. Gelb, S. Sligar, D. Heimbrook, 1982 .

Resonance Raman and magnetic circular dichroism studies of reduced [2Fe-2S] proteins.

S. Sligar, P. Drożdżewski, Michael K. Johnson, 1992, The Journal of biological chemistry.

The CO stretching mode infrared spectrum of substrate-free cytochrome P-450cam-CO: the effect of solvent conditions, temperature, and pressure.

S. Sligar, O. Ristau, H. Schulze, 1996, European journal of biochemistry.

Measurements of CO Geminate Recombination in Cytochromes P450 and P420 (*)

A. V. Wells, S. Sligar, P. Champion, 1995, The Journal of Biological Chemistry.

Resonance Raman detection of bound dioxygen in cytochrome P-450cam.

S. Sligar, A. Rizos, P. Champion, 1986, The Journal of biological chemistry.

Membrane-Bound Ras as a Conformational Clock.

S. Sligar, A. Gorfe, 2020, Biophysical journal.

Ligand binding to heme proteins: III. FTIR studies of His-E7 and Val-E11 mutants of carbonmonoxymyoglobin.

J. Mourant, H. Frauenfelder, P. Ormos, 1993, Biophysical journal.

Photoelectrochemical complexes for solar energy conversion that chemically and autonomously regenerate

Ardemis A. Boghossian, Michael S. Strano, Adam S. Zeiger, 2010, Nature chemistry.

Substrate-Specific Allosteric Effects on the Enhancement of CYP17A1 Lyase Efficiency by Cytochrome b5.

S. Sligar, I. Denisov, J. Kincaid, 2021, Journal of the American Chemical Society.

Femtosecond coherence spectroscopy of heme proteins

S. Sligar, P. Champion, L. Zhu, 1996 .

Imaging and manipulation of high-density lipoproteins.

S. Sligar, A. Jonas, J. W. Carlson, 1997, Biophysical journal.

Resonance Raman characterization of the peroxo and hydroperoxo intermediates in cytochrome P450.

S. Sligar, I. Denisov, J. Kincaid, 2008, The journal of physical chemistry. A.

Mechanism of chromophore assisted laser inactivation employing fluorescent proteins.

K. Jacobson, S. Sligar, Z. Rajfur, 2009, Analytical Chemistry.

Resonance Raman studies of iron spin and axial coordination in distal pocket mutants of ferric myoglobin.

S. Sligar, D. Morikis, P. Champion, 1990, The Journal of biological chemistry.

26 Cytochrome P450 Enzymes

S. Sligar, I. Denisov, 2010 .

Kinetic solvent isotope effect in steady‐state turnover by CYP19A1 suggests involvement of Compound 1 for both hydroxylation and aromatization steps

S. Sligar, Y. Khatri, A. Luthra, 2014, FEBS letters.

Monomeric Rhodopsin Is Sufficient for Normal Rhodopsin Kinase (GRK1) Phosphorylation and Arrestin-1 Binding*

S. Sligar, T. H. Bayburt, V. Gurevich, 2010, The Journal of Biological Chemistry.

Spectroscopic effects of polarity and hydration in the distal heme pocket of deoxymyoglobin.

E. Chien, S. Sligar, P. Champion, 1997, Biochemistry.

Chemical mechanisms for cytochrome P-450 hydroxylation: evidence for acylation of heme-bound dioxygen.

S. Sligar, K. A. Kennedy, D. Pearson, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Cytochrome P-450 and peroxidase chemistry.

S. Sligar, L. Hager, J. Erman, 1994, Advances in inorganic biochemistry.

Tetrameric Hemoglobin Expressed in Escherichia coli

S. Sligar, R. Hernan, 1995, The Journal of Biological Chemistry.

Transient spectroscopy of the reaction of cyanide with ferrous myoglobin. Effect of distal side residues.

M. Brunori, S. Sligar, A. Bellelli, 1990, The Journal of biological chemistry.

Tissue factor/factor VIIa complex: role of the membrane surface.

E. Tajkhorshid, C. Rienstra, S. Sligar, 2012, Thrombosis research.

The Local Phospholipid Environment Modulates the Activation of Blood Clotting*

James H Morrissey, S. Sligar, Stephen G Sligar, 2007, Journal of Biological Chemistry.

Protein–membrane interactions: blood clotting on nanoscale bilayers

E. Tajkhorshid, C. Rienstra, S. Sligar, 2009, Journal of thrombosis and haemostasis : JTH.

Characterization of a cytochrome P450 from the acidothermophilic archaea Sulfolobus solfataricus.

S. Sligar, M. McLean, K. Weiss, 1998, Biochemical and biophysical research communications.

The effect of microsomal fatty acids and other lipids on the spin state of partially purified cytochrome P-450.

S. Sligar, D. L. Cinti, J. Schenkman, 1980, The Journal of biological chemistry.

Kinetic Characterization of Compound I Formation in the Thermostable Cytochrome P450 CYP119*

Stephen G. Sligar, S. Sligar, S. Hung, 2002, The Journal of Biological Chemistry.

Activation of Molecular Oxygen in Cytochromes P450

S. Sligar, I. Denisov, 2015 .

Connection between the taxonomic substates and protonation of histidines 64 and 97 in carbonmonoxy myoglobin.

B. McMahon, E. Chien, S. Sligar, 1999, Biophysical journal.

Mechanisms of Ligand Recognition in Myoglobin

Stephen G. Sligar, Barry A. Springer, John S. Olson, 1994 .

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.

Elizabeth A Ambrose, E. Petricoin, Dafydd G. Thomas, 2017, Cell chemical biology.

Intramolecular electron-transfer reactions of cytochrome b5 covalently bonded to ruthenium(II) polypyridine complexes: reorganizational energy and pressure effects

Jill R. Scott, S. Sligar, B. Durham, 1996 .

Investigations of Anharmonic Low-Frequency Oscillations in Heme Proteins †

D. Barrick, S. Sligar, T. Yonetani, 2002 .

Alteration of heme axial ligands by site-directed mutagenesis: a cytochrome becomes a catalytic demethylase

Dimitrios Morikis, J. Timothy Sage, Stephen G. Sligar, 1987 .

Substrate interaction with cytochrome P-450.

S. Sligar, D. L. Cinti, S. Sligar, 1981, Pharmacology & therapeutics.

Functional implications of the proximal hydrogen-bonding network in myoglobin: a resonance Raman and kinetic study of Leu89, Ser92, His97, and F-helix swap mutants.

J. Friedman, E. Chien, S. Sligar, 1998, Biochemistry.

Selective Examination of Heme Protein Azide Ligand-Distal Globin Interactions by Vibrational Circular Dichroism

K. Gersonde, S. Boxer, S. Asher, 1992 .

Cytochrome c Recognition of Immobilized, Orientational Variants of Cytochrome b5: Direct Force and Equilibrium Binding Measurements

D. Leckband, S. Sligar, T. Kuhl, 1999 .

Single molecule height measurements on a membrane protein in nanometer-scale phospholipid bilayer disks

S. Sligar, T. H. Bayburt, J. W. Carlson, 2000 .

Oxidative cleavage of 1-phenyl-1,2-ethanediol by 4-cyano-N,N-dimethylaniline N-oxide and chloro(5,10,15,20-tetraphenylporphinato)-chromium(III): A model for cholesterol side-chain cleavage by cytochrome P-450SCC

S. Sligar, R. Murray, 1985 .

Interpretation of hyperfine shift patterns in ferricytochromes b5 in terms of angular position of the heme: a sensitive probe for peripheral heme protein interactions.

S. Sligar, G. L. La Mar, K. Mansfield, 1993, Biochimica et biophysica acta.

Distal and proximal ligand interactions in heme proteins: correlations between C-O and Fe-C vibrational frequencies, oxygen-17 and carbon-13 nuclear magnetic resonance chemical shifts, and oxygen-17 nuclear quadrupole coupling constants in C17O- and 13CO-labeled species.

E. Oldfield, S. Sligar, M. Chiu, 1991, Biochemistry.

P450 CYP17A1 variant with a disordered proton shuttle assembly retains peroxo-mediated lyase efficiency.

S. Sligar, I. Denisov, Y. Grinkova, 2020, Chemistry.

Unveiling the crucial intermediates in androgen production

Michael C. Gregory, S. Sligar, I. Denisov, 2015, Proceedings of the National Academy of Sciences.

Nanodiscs for structural and functional studies of membrane proteins

S. Sligar, I. Denisov, Stephen G Sligar, 2016, Nature Structural &Molecular Biology.

Kinetics of hepatic cytochrome P-450 reduction: correlation with spin state of the ferric heme.

S. Sligar, J. Schenkman, W. Backes, 1982, Biochemistry.

Ligand Binding to Cytochrome P450 3A4 in Phospholipid Bilayer Nanodiscs

S. Sligar, Y. Grinkova, W. Atkins, 2007, Journal of Biological Chemistry.

Kinetics of cytochrome P-450 reduction: evidence for faster reduction of the high-spin ferric state.

S. Sligar, J. Schenkman, G. Gibson, 1985, Biochemistry.

Temperature-dependent spin equilibrium of microsomal and solubilized cytochrome P-450 from rat liver.

S. Sligar, D. L. Cinti, J. Schenkman, 1979, Biochemistry.

PHOTOCLEAVAGE OF DNA: IRRADIATION OF QUINONE‐CONTAINING REAGENTS CONVERTS SUPERCOILED TO LINEAR DNA

S. Sligar, J. D. Ropp, T. Koch, 1993, Photochemistry and photobiology.

Nanodiscs in Membrane Biochemistry and Biophysics.

S. Sligar, I. Denisov, Stephen G Sligar, 2017, Chemical reviews.

Kinetics of dithionite-dependent reduction of cytochrome P450 3A4: heterogeneity of the enzyme caused by its oligomerization.

S. Sligar, J. Halpert, B. Baas, 2005, Biochemistry.

Intersubunit circular permutation of human hemoglobin.

K. E. Sanders, S. Sligar, John Lo, 2002, Blood.

Membrane topology of cytochrome P450 2B4 in Langmuir-Blodgett monolayers.

M. J. Coon, S. Sligar, G. Raner, 1998, Archives of biochemistry and biophysics.

1H NMR study of the solution molecular and electronic structure of Escherichia coli ferricytochrome b562: evidence for S = 1/2 in equilibrium S = 5/2 spin equilibrium for intact His/Met ligation.

S. Sligar, M. Chiu, F. Walker, 1991, Biochemistry.

Transducin Activation by Nanoscale Lipid Bilayers Containing One and Two Rhodopsins*

D. Oprian, S. Sligar, T. H. Bayburt, 2007, Journal of Biological Chemistry.

Investigations of the resonance Raman excitation profiles of cytochrome P450cam

S. Martinis, S. Sligar, P. Champion, 1987 .

Resonance Raman investigations of Escherichia coli-expressed Pseudomonas putida cytochrome P450 and P420.

A. V. Wells, S. Martinis, S. Sligar, 1992, Biochemistry.

The iron-histidine mode of myoglobin revisited: resonance Raman studies of isotopically labeled Escherichia coli-expressed myoglobin

A. V. Wells, S. Sligar, M. Chiu, 1991 .

Nanodiscs as a new tool to examine lipid-protein interactions.

S. Sligar, M. Schuler, I. Denisov, 2013, Methods in molecular biology.

Engineering extended membrane scaffold proteins for self-assembly of soluble nanoscale lipid bilayers.

S. Sligar, I. Denisov, Y. Grinkova, 2010, Protein engineering, design & selection : PEDS.

Membrane protein assembly into Nanodiscs

S. Sligar, T. H. Bayburt, Stephen G Sligar, 2010, FEBS letters.

Nanodiscs separate chemoreceptor oligomeric states and reveal their signaling properties.

Mingshan Li, S. Sligar, G. L. Hazelbauer, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Direct solubilization of heterologously expressed membrane proteins by incorporation into nanoscale lipid bilayers.

S. Sligar, M. Schuler, T. H. Bayburt, 2003, BioTechniques.

Genetic variants in the putidaredoxin-cytochrome P-450cam electron-transfer complex: identification of the residue responsible for redox-state-dependent conformers.

S. Sligar, M. D. Davies, 1992, Biochemistry.

Role of the arginine-45 salt bridge in ligand dissociation from sperm whale carboxymyoglobin as probed by photoacoustic calorimetry.

S. Sligar, J. D. Ropp, J. Westrick, 1990, Biochemistry.

Modulation of the cytochrome P450 reductase redox potential by the phospholipid bilayer.

A. Das, S. Sligar, Stephen G Sligar, 2009, Biochemistry.

Conformational dynamics of cytochrome P-450cam as monitored by photoacoustic calorimetry.

C. Di Primo, S. Sligar, E. Deprez, 1993, Biochemistry.

Photoacoustic calorimetry of proteins.

C. Di Primo, G. H. Hoa, S. Sligar, 1998, Methods in enzymology.

Probing the heme iron coordination structure of alkaline chloroperoxidase.

S. Martinis, S. Sligar, S. Blanke, 1996, Biochemistry.

Cloning and expression of a member of a new cytochrome P-450 family: cytochrome P-450lin (CYP111) from Pseudomonas incognita

S. Sligar, S. Sligar, J. D. Ropp, 1993, Journal of bacteriology.

Controlling the regiospecificity and coupling of cytochrome P450cam: T185F mutant increases coupling and abolishes 3‐hydroxynorcamphor product

R. Ornstein, S. Sligar, M. Paulsen, 1993, Protein science : a publication of the Protein Society.

Chemical mechanisms for cytochroni Evidence for acylation of heme-boun (cytochrome P-450 mechanismn/acyl peroxide intermediate/oxygen-:

S. Sligar, Katherine A. KENNEDYt, Oavid C. Pearson, 2016 .

Femtosecond Coherence Spectroscopy of Heme Proteins

S. Sligar, P. Champion, L. Zhu, 1994, Ultrafast Phenomena.

Effect of the tyrosine 96 hydrogen bond on the inactivation of cytochrome P-450cam induced by hydrostatic pressure.

C. Di Primo, S. Sligar, C. D. Primo, 1990, European journal of biochemistry.

Microfluidic platform for efficient Nanodisc assembly, membrane protein incorporation, and purification.

S. Sligar, Ivan L Lenov, Joshua D. Jones, 2017, Lab on a chip.

Directed self-assembly of monodisperse phospholipid bilayer Nanodiscs with controlled size.

S. Sligar, I. Denisov, Y. Grinkova, 2004, Journal of the American Chemical Society.

Energetics of heme binding to native and denatured states of cytochrome b562.

S. Sligar, J. Thomson, J. Sturtevant, 1997, Biochemistry.

Cloning and expression of the gene encoding the soluble cytochrome b562 of Escherichia coli.

R. Gennis, S. Sligar, H. Nikkila, 1991, European journal of biochemistry.

Cytochrome b5 enhances androgen synthesis by rapidly reducing the CYP17A1 oxy‐complex in the lyase step

S. Sligar, I. Denisov, Ruchia Duggal, 2018, FEBS letters.

Characterizing the Membrane-Bound State of Cytochrome P450 3A4: Structure, Depth of Insertion, and Orientation

Emad Tajkhorshid, Stephen G. Sligar, E. Tajkhorshid, 2013, Journal of the American Chemical Society.

Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone.

Michael C. Gregory, S. Sligar, I. Denisov, 2018, Journal of the American Chemical Society.

Evidence that cytochrome b5 acts as a redox donor in CYP17A1 mediated androgen synthesis.

Michael C. Gregory, S. Sligar, I. Denisov, 2016, Biochemical and biophysical research communications.

Kinetic solvent isotope effect in human P450 CYP17A1-mediated androgen formation: evidence for a reactive peroxoanion intermediate.

S. Sligar, I. Denisov, Y. Grinkova, 2013, Journal of the American Chemical Society.

Functional reconstitution of monomeric CYP3A4 with multiple cytochrome P450 reductase molecules in Nanodiscs.

S. Sligar, I. Denisov, Y. Grinkova, 2010, Biochemical and biophysical research communications.

The Ferrous-Dioxygen Intermediate in Human Cytochrome P450 3A4

S. Sligar, I. Denisov, Y. Grinkova, 2006, Journal of Biological Chemistry.

Surface electrostatics, reduction potentials, and the internal dielectric constant of proteins

S. Sligar, K. Rodgers, 1991 .

Cryoradiolysis of oxygenated cytochrome P450 17A1 with lyase substrates generates expected products

S. Sligar, I. Denisov, J. Kincaid, 2021 .

Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202.

S. Sligar, Y. Khatri, J. Kincaid, 2017, Biochemistry.

Differential hydrogen bonding in human CYP17 dictates hydroxylation versus lyase chemistry.

Michael C. Gregory, S. Sligar, J. Kincaid, 2013, Angewandte Chemie.

Hydroxylation of camphor by reduced oxy-cytochrome P450cam: mechanistic implications of EPR and ENDOR studies of catalytic intermediates in native and mutant enzymes.

S. Sligar, B. Hoffman, S G Sligar, 2001, Journal of the American Chemical Society.

Importance of Asparagine 202 in Manipulating Active Site Structure and Substrate Preference for Human CYP17A1.

Michael C. Gregory, S. Sligar, I. Denisov, 2022, Biochemistry.

Mechanism of the Clinically Relevant E305G Mutation in Human P450 CYP17A1.

Michael C. Gregory, S. Sligar, I. Denisov, 2021, Biochemistry.

Putidaredoxin competitively inhibits cytochrome b5-cytochrome P-450cam association: a proposed molecular model for a cytochrome P-450cam electron-transfer complex.

T. Poulos, S. Sligar, P. Stayton, 1989, Biochemistry.

The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4.

S. Sligar, G. Bérubé, I. Denisov, 2016, Journal of inorganic biochemistry.

Resonance Raman Spectroscopy of the Oxygenated Intermediates of Human CYP19A1 Implicates a Compound I Intermediate in the Final Lyase Step

S. Sligar, J. Kincaid, A. Luthra, 2014, Journal of the American Chemical Society.

The Charge Properties of Phospholipid Nanodiscs.

S. Sligar, T. Laue, M. McLean, 2016, Biophysical journal.

Blood clotting reactions on nanoscale phospholipid bilayers.

James H Morrissey, Emad Tajkhorshid, E. Tajkhorshid, 2008, Thrombosis research.

Nanodiscs: A Controlled Bilayer Surface for the Study of Membrane Proteins.

Michael C. Gregory, S. Sligar, M. McLean, 2018, Annual review of biophysics.

Interaction of KRas4b with anionic membranes: A special role for PIP2.

Michael C. Gregory, S. Sligar, M. McLean, 2017, Biochemical and biophysical research communications.

Dissecting the molecular origins of specific protein-nucleic acid recognition: hydrostatic pressure and molecular dynamics.

Klaus Schulten, Dorina Kosztin, K. Schulten, 2002, Biophysical journal.

Human hemoglobin expression in Escherichia coli: importance of optimal codon usage.

S. Sligar, J. Walder, R. Walder, 1992, Biochemistry.

Changes in solvation during DNA binding and cleavage are critical to altered specificity of the EcoRI endonuclease.

S. Sligar, S. Sligar, C R Robinson, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Hydrostatic and osmotic pressure as tools to study macromolecular recognition.

S. Sligar, S. Sligar, C R Robinson, 1995, Methods in enzymology.

Hydrostatic pressure reverses osmotic pressure effects on the specificity of EcoRI-DNA interactions.

S. Sligar, C. R. Robinson, 1994, Biochemistry.

Biomimetic chemical sensors using nanoelectronic readout of olfactory receptor proteins.

Alan Gelperin, A. Gelperin, Mitchell B. Lerner, 2011, ACS nano.

Mapping electrostatic interactions in macromolecular associations.

S. Sligar, K. Rodgers, Karla K. Rodgers, 1991, Journal of molecular biology.

Probing the mechanisms of macromolecular recognition: the cytochrome b5-cytochrome c complex.

S. Sligar, K. Rodgers, T. Pochapsky, 1988, Science.

Formation and Decay of Hydroperoxo-Ferric Heme Complex in Horseradish Peroxidase Studied by Cryoradiolysis*

S. Sligar, I. Denisov, T. Makris, 2002, The Journal of Biological Chemistry.

Assembly of lipids and proteins into lipoprotein particles.

Klaus Schulten, Peter L. Freddolino, Peter L Freddolino, 2007, The journal of physical chemistry. B.

High-pressure denaturation of apomyoglobin.

S. Sligar, S. Bondos, J. Jonas, 2000, Biochimica et biophysica acta.

Characterization of cytochrome b5 reconstituted with a ferric chlorin and a ferric oxochlorin.

S. Martinis, S. Sligar, C. Sotiriou, 1989, Biochemistry.

Probing the heme iron coordination structure of pressure-induced cytochrome P420cam.

S. Martinis, G. H. Hoa, S. Sligar, 1996, Biochemistry.

The ferric-hydroperoxo complex of chloroperoxidase.

S. Sligar, J. Dawson, I. Denisov, 2007, Biochemical and biophysical research communications.

Nanodisc-solubilized membrane protein library reflects the membrane proteome

W. Klein, S. Sligar, K. Wilcox, 2013, Analytical and Bioanalytical Chemistry.

Nonlinear analyte concentration gradients for one-step kinetic analysis employing optical microring resonators.

Ryan C Bailey, S. Sligar, R. Bailey, 2012, Analytical chemistry.

Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket.

S. Sligar, J. Halpert, B. Baas, 2007, Biochemistry.

Heme-pocket-hydration change during the inactivation of cytochrome P-450camphor by hydrostatic pressure.

C. Di Primo, S. Sligar, G. Hui Bon Hoa, 1992, European journal of biochemistry.

Conformational changes of cytochromes P-450cam and P-450lin induced by high pressure.

C. Di Primo, S. Sligar, I. C. Gunsalus, 1989, Biochemistry.

High-pressure investigations of cytochrome P-450 spin and substrate binding equilibria.

S. Sligar, S. Scarlata, M. Fisher, 1985, Archives of biochemistry and biophysics.

Control and recognition of anionic ligands in myoglobin

M. Brunori, M. Bolognesi, S. Sligar, 1991, FEBS letters.

Alteration of sperm whale myoglobin heme axial ligation by site-directed mutagenesis.

S. Martinis, S. Sligar, D. Morikis, 1990, Biochemistry.

The role of Thr268 in oxygen activation of cytochrome P450BM-3.

T. Poulos, S. Sligar, Huiying Li, 1995, Biochemistry.

Understanding Cooperativity in Human P450 Mediated Drug-Drug Interactions

S. Sligar, I. Denisov, 2007, Drug metabolism reviews.

Chapter 16 – Structure, behavior, and manipulation of nanoscale biological assemblies

S. Sligar, T. H. Bayburt, M. Shank-Retzlaff, 2002 .

Structure, behavior, and manipulation of nanoscale biological assemblies

S. Sligar, T. H. Bayburt, M. Shank-Retzlaff, 2000 .

Functional reconstitution of Beta2-adrenergic receptors utilizing self-assembling Nanodisc technology.

S. Sligar, T. H. Bayburt, Stephen G Sligar, 2006, BioTechniques.

Thermotropic phase transition in soluble nanoscale lipid bilayers.

S. Sligar, I. Denisov, Y. Grinkova, 2005, The journal of physical chemistry. B.

Phospholipid phase transitions in homogeneous nanometer scale bilayer discs

S. Sligar, Stephen G Sligar, Andrew W Shaw, 2004, FEBS letters.

Reconstitution and imaging of a membrane protein in a nanometer-size phospholipid bilayer.

S. Sligar, T. H. Bayburt, J. W. Carlson, 1998, Journal of structural biology.

Biotransformation of the Mycotoxin Enniatin B1 by CYP P450 3A4 and Potential for Drug-Drug Interactions

S. Sligar, C. Fæste, I. Denisov, 2019, Metabolites.

Spin state control of the hepatic cytochrome P450 redox potential.

S. Sligar, D. L. Cinti, J. Schenkman, 1979, Biochemical and biophysical research communications.

Regioselectivity in the cytochromes P-450: control by protein constraints and by chemical reactivities.

S. Sligar, K. Egeberg, M. McCarthy, 1984, Archives of biochemistry and biophysics.

Cooperativity in Cytochrome P450 3A4

S. Sligar, I. Denisov, Y. Grinkova, 2007, Journal of Biological Chemistry.

Exploring the Electron Transfer Properties of Neuronal Nitric-oxide Synthase by Reversal of the FMN Redox Potential*

T. Poulos, S. Sligar, Huiying Li, 2008, Journal of Biological Chemistry.

Protein engineering for studying enzyme catalytic mechanism

S. Sligar, W. Atkins, 1991 .

A Topographic View of Supercooled Liquids and Glass Formation

B. F. Rasmussen, H. Frauenfelder, E. Mayer, 2005 .

Electrostatic stabilization in four‐helix bundle proteins

S. Sligar, C. R. Robinson, 1993, Protein science : a publication of the Protein Society.

A differential scanning calorimetric study of the thermal unfolding of apo‐ and holo‐cytochrome b562

S. Sligar, J. Sturtevant, R. O'brien, 1998, Protein science : a publication of the Protein Society.

Mutagenesis of cytochromes P450cam and b5.

S. Sligar, P. Stayton, D. Filipovic, 1991, Methods in enzymology.

Metabolic switching in cytochrome P-450cam: Deuterium isotope effects on regiospecificity and the monooxygenase/oxidase ratio

S. Sligar, W. Atkins, 1987 .

Control of heme protein redox potential and reduction rate: linear free energy relation between potential and ferric spin state equilibrium

Mark T. Fisher, Stephen G. Sligar, S. Sligar, 1985 .

PIP2 Influences the Conformational Dynamics of Membrane bound KRAS4b

S. Sligar, A. Stephen, M. McLean, 2019, bioRxiv.

Nanodisc self-assembly is thermodynamically reversible and controllable.

S. Sligar, Tyler Camp, 2020, Soft matter.

Molecular orientation determination in Nanodiscs at the single-molecule level.

S. Sligar, Kai Zhang, Tyler Camp, 2019, Analytical chemistry.

The hydrodynamic motion of Nanodiscs.

S. Sligar, M. McLean, Lionel Cheruzel, 2019, Chemistry and physics of lipids.

Nanodiscs as a New Tool to Examine Lipid-Protein Interactions.

S. Sligar, M. Schuler, I. Denisov, 2019, Methods in molecular biology.

SMPL Synaptic Membranes: Nanodisc-Mediated Synaptic Membrane Mimetics Expand the Toolkit for Drug Discovery and the Molecular Cell Biology of Synapses

W. Klein, S. Sligar, Riana Lo Bu, 2018 .

The heme iron coordination complex in His64(E7)Tyr recombinant sperm whale myoglobin.

S. Sligar, M. Chiu, I. Ascone, 1994, Biochemistry.

Alzheimer’s Toxic Amyloid Beta Oligomers: Unwelcome Visitors to the Na/K ATPase alpha3 Docking Station

D. Brody, W. Klein, S. Sligar, 2017, The Yale journal of biology and medicine.

Nanodiscs as a therapeutic delivery agent: inhibition of respiratory syncytial virus infection in the lung

S. Sligar, D. Voelker, Y. Grinkova, 2013, International journal of nanomedicine.

Reduction kinetics of purified rat liver cytochrome P-450. Evidence for a sequential reaction mechanism dependent on the hemoprotein spin state.

S. Sligar, J. Schenkman, G. Gibson, 1984, Biochemistry.

THE ROLES OF MEMBRANE AND SUBSTRATES IN THE MODULATION OF CYTOCHROME P-450 FUNCTION

S. Sligar, D. L. Cinti, J. Schenkman, 1980 .

Allosteric Interactions in Human Cytochrome P450 CYP3A4: The Role of Phenylalanine 213.

E. Tajkhorshid, S. Sligar, Prithviraj Nandigrami, 2019, Biochemistry.

Resonance surface plasmon spectroscopy: low molecular weight substrate binding to cytochrome p450.

R. V. Van Duyne, Xiaoyu Zhang, G. Schatz, 2006, Journal of the American Chemical Society.

Nature's universal oxygenases: the cytochromes P450.

S. Sligar, 1999, Essays in biochemistry.

Cooperative properties of cytochromes P450.

S. Sligar, I. Denisov, Daniel J. Frank, 2009, Pharmacology & therapeutics.

Structural analysis of nanoscale self-assembled discoidal lipid bilayers by solid-state NMR spectroscopy.

Ying Li, C. Rienstra, S. Sligar, 2006, Biophysical journal.

Resonance Raman spectroscopic studies of hydroperoxo-myoglobin at cryogenic temperatures.

Mohammed Salah Ibrahim, S. Sligar, I. Denisov, 2003, Journal of the American Chemical Society.

Chapter 11 Molecular Modeling of the Structural Properties and Formation of High-Density Lipoprotein Particles

Peter L. Freddolino, K. Schulten, A. Arkhipov, 2008 .

CONTRIBUTION OF DIFFERENT TYPES OF PHOSPHOLIPIDS IN BLOOD COAGULATION

S. Sligar, 2013 .

Heterogeneity in molecular recognition by restriction endonucleases: osmotic and hydrostatic pressure effects on BamHI, Pvu II, and EcoRV specificity.

S. Sligar, C. R. Robinson, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Contributions of residue 45(CD3) and heme-6-propionate to the biomolecular and geminate recombination reactions of myoglobin.

S. Krzywda, S. Smerdon, S. Sligar, 1991, Biochemistry.

Pressure dissociation of a protein-protein electron-transfer complex

S. Sligar, M. Fisher, R. E. White, 1986 .

Maturation of high-density lipoproteins

K. Schulten, S. Sligar, A. Shih, 2009, Journal of The Royal Society Interface.

Molecular models need to be tested: the case of a solar flares discoidal HDL model.

K. Schulten, S. Sligar, A. Shih, 2008, Biophysical journal.

Fluorescent Probes for Rapid Screening of Potential Drug–Drug Interactions at the CYP3A4 Level

S. Sligar, W. Woggon, A. Chougnet, 2007, ChemMedChem.

OXIDATIVE CLEAVAGE OF 1-PHENYL-1,2-ETHANEDIOL BY 4-CYANO-N,N-DIMETHYLANILINE N-OXIDE AND CHLORO(5,10,15,20-TETRAPHENYLPORPHINATO)CHROMIUM(III): A MODEL FOR CHOLESTEROL SIDE-CHAIN CLEAVAGE BY CYTOCHROME P-450SCC

S. Sligar, R. Murray, 1985 .

MUTANT AND WILD-TYPE MYOGLOBIN-CO PROTEIN DYNAMICS : VIBRATIONAL ECHO EXPERIMENTS

E. Chien, S. Sligar, M. Fayer, 1997 .

NMR analysis of free and lipid nanodisc anchored CEACAM1 membrane proximal peptides with Ca2+/CaM.

N. Vaidehi, S. Sligar, J. Shively, 2019, Biochimica et biophysica acta. Biomembranes.

Resonance Localized Surface Plasmon Spectroscopy: Sensing Substrate and Inhibitor Binding to Cytochrome P450

G. Schatz, A. Das, S. Sligar, 2008 .

X-ray absorption spectroscopic characterization of a cytochrome P450 compound II derivative

S. Sligar, Lin X. Chen, M. Newcomb, 2008, Proceedings of the National Academy of Sciences.

Interfacing lipid bilayer nanodiscs and silicon photonic sensor arrays for multiplexed protein-lipid and protein-membrane protein interaction screening.

Ryan C Bailey, S. Sligar, R. Bailey, 2013, Analytical chemistry.

Microfluidic patterning of nanodisc lipid bilayers and multiplexed analysis of protein interaction.

Chang Liu, S. Sligar, E. Goluch, 2008, Lab on a chip.

The One-electron Autoxidation of Human Cytochrome P450 3A4*

S. Sligar, I. Denisov, Y. Grinkova, 2007, Journal of Biological Chemistry.

Understanding the role of the essential Asp251 in cytochrome p450cam using site-directed mutagenesis, crystallography, and kinetic solvent isotope effect.

T. Poulos, S. Sligar, Huiying Li, 1998, Biochemistry.

Understanding thermostability in cytochrome P450 by combinatorial mutagenesis

S. Sligar, Shelley A. Maves, Stephen G. Sligar, 2001, Protein science : a publication of the Protein Society.

Cytochromes P450 in nanodiscs.

S. Sligar, I. Denisov, 2011, Biochimica et biophysica acta.

SPIN STATES AND REDOX POTENTIALS OF HEPATIC CYTOCHROME P450

S. Sligar, J. Schenkman, G. Gibson, 1980 .

Ligand binding to heme proteins. V. Light-induced relaxation in proximal mutants L89I and H97F of carbonmonoxymyoglobin.

E. Chien, S. Sligar, G. Nienhaus, 1995, Biophysical journal.

Crystal structure of myoglobin form a synthetic gene

S. Sligar, G. Phillips, R. Arduini, 1990, Proteins.

Genetic engineering of redox donor sites: measurement of intracomplex electron transfer between ruthenium-65-cytochrome b5 and cytochrome c.

S. Sligar, P. Stayton, B. Durham, 1992, Biochemistry.

Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer’s-Associated Aβ Oligomers

C. Luan, W. Klein, A. Das, 2015, PloS one.

Screening of type I and II drug binding to human cytochrome P450-3A4 in nanodiscs by localized surface plasmon resonance spectroscopy.

George C Schatz, Richard P Van Duyne, R. V. Van Duyne, 2009, Analytical chemistry.

Characterization of the oxygenated intermediate of the thermophilic cytochrome P450 CYP119.

S. Sligar, P. Champion, I. Denisov, 2001, Journal of inorganic biochemistry.

Deuterium isotope effects in norcamphor metabolism by cytochrome P-450cam: kinetic evidence for the two-electron reduction of a high-valent iron-oxo intermediate.

S. Sligar, W. Atkins, 1988, Biochemistry.

A conserved residue of cytochrome P-450 is involved in heme-oxygen stability and activation

S. Martinis, S. Sligar, P. Stayton, 1989 .

Experimental and theoretical high pressure strategies for investigating protein-nucleic acid assemblies.

S. Sligar, T. W. Lynch, 2002, Biochimica et biophysica acta.

Chemical mechanisms for cytochrome P-450 oxidation: spectral and catalytic properties of a manganese-substituted protein.

M. Gelb, S. Sligar, W. A. Toscano, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Engineering cytochrome P450s for bioremediation.

S. Sligar, D. G. Kellner, S. A. Maves, 1997, Current opinion in biotechnology.

Midazolam as a Probe for Drug-Drug Interactions Mediated by CYP3A4: Homotropic Allosteric Mechanism of Site-Specific Hydroxylation.

S. Sligar, I. Denisov, Y. Grinkova, 2021, Biochemistry.

The roles of active site hydrogen bonding in cytochrome P-450cam as revealed by site-directed mutagenesis.

S. Sligar, W. Atkins, 1988, The Journal of biological chemistry.

A fluorescence resonance energy transfer activation sensor for Arf6.

S. Sligar, M. Schwartz, J. Casanova, 2008, Analytical biochemistry.

Preparation and kinetic characterization of a series of betaW37 variants of human hemoglobin A: evidence for high-affinity T quaternary structures.

K. E. Sanders, S. Sligar, E. Peterson, 1998, Biochemistry.

Loss of allosteric behaviour in recombinant hemoglobin α 2 β 29r)F8)His→Ala: Restoration upon addition of strong effectors

S. Sligar, L. Kiger, M. Marden, 1995 .

Probing heme protein conformational equilibration rates with kinetic selection.

E. Chien, S. Sligar, P. Champion, 1996, Biochemistry.

The critical iron-oxygen intermediate in human aromatase.

S. Sligar, I. Denisov, Y. Grinkova, 2009, Biochemical and biophysical research communications.

Molecular recognition in cytochrome P-450: mechanism for the control of uncoupling reactions.

S. Sligar, P. Loida, 1993, Biochemistry.

Functional assays of membrane-bound proteins with SAMDI-TOF mass spectrometry.

S. Sligar, M. Mrksich, T. H. Bayburt, 2007, Angewandte Chemie.

Resonance Raman studies of cytochrome P450BM3 and its complexes with exogenous ligands.

S. Sligar, L. Proniewicz, J. Kincaid, 1999, Biochemistry.

Reduced oxy intermediate observed in D251N cytochrome P450cam.

D. E. Benson, K. Suslick, S. Sligar, 1997, Biochemistry.

A novel type of allosteric regulation: functional cooperativity in monomeric proteins.

S. Sligar, I. Denisov, 2012, Archives of biochemistry and biophysics.

Investigation of the low frequency dynamics of heme proteins: native and mutant cytochrome P450(cam) and redox partner complexes.

S. Sligar, P. Champion, I. Denisov, 2011, The journal of physical chemistry. B.

Origin of the photoacoustic signal in cytochrome P-450cam: role of the Arg186-Asp251-Lys178 bifurcated salt bridge.

C. Di Primo, S. Sligar, E. Deprez, 1997, Biochemistry.

Lipid-protein correlations in nanoscale phospholipid bilayers determined by solid-state nuclear magnetic resonance.

Andrew J. Nieuwkoop, K. Schulten, C. Rienstra, 2010, Biochemistry.

Assembly of an activated rhodopsin-transducin complex in nanoscale lipid bilayers.

D. Oprian, S. Sligar, A. D'Antona, 2014, Biochemistry.

Stereoselective Hydroxylation of Norcamphor by Cytochrome P450cam

R. Ornstein, S. Sligar, G. Arnold, 1995, The Journal of Biological Chemistry.

Engineering C-C Bond Cleavage Activity into a P450 Monooxygenase Enzyme.

S. Sligar, S. Bell, M. Schuler, 2023, Journal of the American Chemical Society.

Surface-Linked Molecular Monolayers of an Engineered Myoglobin: Structure, Stability, and Function

S. Sligar, P. Stayton, Min Jiang, 1996 .

Influence of proximal side mutations on the molecular and electronic structure of cyanomet myoglobin: an 1H NMR study.

E. Chien, S. Sligar, G. L. La Mar, 1998, Biochemistry.

Electron Transfer between Cytochrome P450cin and Its FMN-containing Redox Partner, Cindoxin*

T. Poulos, S. Sligar, Aditi Das, 2007, Journal of Biological Chemistry.

Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: the effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium.

S. Sligar, J. Halpert, S. Sistla, 2010, Biochimica et biophysica acta.

The formation of cytochrome P-450 from cytochrome P-420 is promoted by spermine.

C. Di Primo, S. Sligar, G. Hui Bon Hoa, 1990, Biochemistry.

Identification of the Fe−O−O Bending Mode in Oxycytochrome P450cam by Resonance Raman Spectroscopy

S. Sligar, P. Champion, M. Unno, 1999 .

Defining CYP3A4 structural responses to substrate binding. Raman spectroscopic studies of a nanodisc-incorporated mammalian cytochrome P450.

Stephen G. Sligar, S. Sligar, I. Denisov, 2011, Journal of the American Chemical Society.

Solvent isotope effects in the catalytic cycle of P450 CYP17A1: Computational modeling of the hydroxylation and lyase reactions.

S. Sligar, I. Denisov, 2023, Journal of inorganic biochemistry.

A role for Asp-251 in cytochrome P-450cam oxygen activation.

S. Sligar, S G Sligar, N C Gerber, 1994, The Journal of biological chemistry.

Oxygen sensing heme proteins: monoxygenases, myoglobin and hemoglobin.

H. Frauenfelder, S. Sligar, I. C. Gunsalus, 1977, Advances in experimental medicine and biology.

The electromechanics of DNA in a synthetic nanopore.

K. Schulten, P. Marks, G. Timp, 2006, Biophysical journal.

A role of the putidaredoxin COOH-terminus in P-450cam (cytochrome m) hydroxylations.

S. Sligar, S. Sligar, J. Lipscomb, 1974, Proceedings of the National Academy of Sciences of the United States of America.

A FRET Activation Sensor for Arf6

S. Sligar, M. Schwartz, J. Casanova, 2008 .

Revealing KRas4b topology on the membrane surface.

S. Sligar, A. Stephen, S. Shree, 2023, Biochemical and biophysical research communications.

High pressure gel mobility shift analysis and molecular dynamics: Investigating specific protein-nucleic acid recognition

K. Schulten, S. Sligar, M. McLean, 2002 .

Determination of the orientation of the magnetic axes of the cyano-MetMb complexes of point mutants of myoglobin by solution 1H NMR : influence of His E7 → Gly and Arg CD3 → Gly substitutions

S. Sligar, M. Chiu, K. Rajarathnam, 1992 .

Product Formation from Ferrous Oxy-Cytochrome P-450

S. Sligar, I. C. Gunsalus, P. Debrunner, 1975 .

Molecular recognition in cytochrome P-450: Alteration of regioselective alkane hydroxylation via protein engineering

S. Sligar, W. Atkins, 1989 .

Recreation of the terminal events in physiological integrin activation

S. Sligar, K. Taylor, A. Bobkov, 2010, The Journal of cell biology.

Ultra-thin layer MALDI mass spectrometry of membrane proteins in nanodiscs

A. Das, S. Sligar, M. Marty, 2011, Analytical and Bioanalytical Chemistry.

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

Christopher S. Chen, T. Ha, S. Sligar, 2010, Nature.

Mutagenesis of a single hydrogen bond in cytochrome P-450 alters cation binding and heme solvation.

C. Di Primo, S. Sligar, G. Hui Bon Hoa, 1990, The Journal of biological chemistry.

Cooperativity in P450 CYP3A4: Linkages in Substrate Binding, Spin State, Uncoupling and Product Formation *

S. Sligar, I. Denisov, Y. Grinkova, 2007 .

Identification of 2Fe-2S cysteine ligands in putidaredoxin.

S. Sligar, T. Horiuchi, H. Koga, 1990, Biochemical and biophysical research communications.

Application of fragment-based drug discovery to membrane proteins: identification of ligands of the integral membrane enzyme DsbB.

G. Siegal, S. Sligar, Yunpeng Zhou, 2010, Chemistry & biology.

Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 binding.

S. Sligar, G. Schertler, V. Gurevich, 2013, Cellular signalling.

Participation of water in Hin recombinase-DNA recognition

S. Sligar, '. CLIFFORDR.ROBINSON, 2002 .

Engineering extended membrane scaffold proteins for self-assembly of soluble nanoscale lipid bilayers.

S. Sligar, I. Denisov, Y. Grinkova, 2010, Protein engineering, design & selection : PEDS.

Effect of heme binding on the structure and stability of Escherichia coli apocytochrome b562.

S. Sligar, Y. Feng, 1991, Biochemistry.

Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202.

Michael C. Gregory, S. Sligar, Y. Khatri, 2017, Biochemistry.

Kinetic solvent isotope effect in human P450 CYP17A1-mediated androgen formation: evidence for a reactive peroxoanion intermediate.

Michael C. Gregory, S. Sligar, I. Denisov, 2013, Journal of the American Chemical Society.

Mixing apples and oranges: Analysis of heterotropic cooperativity in cytochrome P450 3A4.

S. Sligar, I. Denisov, Daniel J. Frank, 2009, Archives of biochemistry and biophysics.

The cytochrome P-450cam binding surface as defined by site-directed mutagenesis and electrostatic modeling.

S. Sligar, P. Stayton, 1990, Biochemistry.

The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4.

S. Sligar, G. Bérubé, I. Denisov, 2016, Journal of inorganic biochemistry.

Analysis of Heterotropic Cooperativity in Cytochrome P450 3A4 Using α-Naphthoflavone and Testosterone*

S. Sligar, I. Denisov, Daniel J. Frank, 2010, The Journal of Biological Chemistry.

Oxidase uncoupling in heme monooxygenases: human cytochrome P450 CYP3A4 in Nanodiscs.

S. Sligar, I. Denisov, Y. Grinkova, 2013, Biochemical and biophysical research communications.

The critical iron-oxygen intermediate in human aromatase.

S. Sligar, I. Denisov, Y. Grinkova, 2009, Biochemical and biophysical research communications.

Disassembly of nanodiscs with cholate.

Klaus Schulten, Peter L Freddolino, Amy Y Shih, 2007, Nano letters.

Detecting SNPs using a synthetic nanopore.

G. Timp, S. Sligar, A. Aksimentiev, 2007, Nano letters.

A novel series of pEX-PINK expression vectors for screening high-level production of (un)fused foreign proteins by rapid visual detection of PINK Escherichia coli clones.

E. Mercer, S. Sligar, J. Gallagher, 1990, Nucleic acids research.

1H and 15N resonance assignments and secondary structure of the carbon monoxide complex of sperm whale myoglobin

P. Wright, Y. Thériault, S. Sligar, 1994, Journal of biomolecular NMR.

1H and 15N NMR resonance assignments and preliminary structural characterization of Escherichia coli apocytochrome b562.

A. Wand, S. Sligar, Y. Feng, 1991, Biochemistry.

Complex Formation of Cytochrome P450cam with Putidaredoxin

D. E. Benson, S. Sligar, P. Champion, 2002, The Journal of Biological Chemistry.

Ethylbenzene hydroxylation by cytochrome P450cam.

R. Ornstein, S. Sligar, M. Paulsen, 1992, Biochemical and biophysical research communications.

Superoxide anion production by the autoxidation of cytochrome P450cam.

S. Sligar, S. Sligar, J. Lipscomb, 1974, Biochemical and biophysical research communications.

Electrostatic control of the substrate access channel in cytochrome P-450cam.

S. Sligar, C. D. Primo, Gaston Hui Bon Hoa, 1994, Biochemistry.

A critical role of protein‐bound water in the catalytic cycle of cytochrome P‐450 camphor

C. Di Primo, G. H. Hoa, S. Sligar, 1992, FEBS letters.

INFLUENCE OF SUBSTRATES OF HEPATIC MIXED FUNCTION OXIDASES ON SPIN EQUILIBRIUM OF CYTOCHROME P-450

S. Sligar, D. L. Cinti, J. Schenkman, 1980 .

Oxygen activation by cytochrome P450BM-3: effects of mutating an active site acidic residue.

S. Sligar, H. Yeom, 1997, Archives of biochemistry and biophysics.

Adiabatic compressibility of molten globules.

S. Sligar, B. Nölting, 1993, Biochemistry.

Nanodiscs for the study of membrane proteins.

S. Sligar, I. Denisov, 2024, Current opinion in structural biology.

Decreased substrate affinity upon alteration of the substrate‐docking region in cytochrome P450BM‐3

S. Sligar, M. McLean, H. Yeom, 1997, FEBS letters.

High pressure, a tool for exploring heme protein active sites.

S. Sligar, M. McLean, G. Hui Bon Hoa, 2002, Biochimica et Biophysica Acta.

THERMOPHILIC CYTOCHROME P450 (CYP119) FROM SULFOLOBUS SOLFATARICUS: HIGH RESOLUTION STRUCTURAL ORIGIN OF ITS THERMOSTABILITY AND FUNCTIONAL PROPERTIES

S. Sligar, S. Adachi, Proteomics Initiative, 2001 .

Putidaredoxin Reduction of Cytochrome P-450 cam: Dependence of Electron Transfer on the Identity of Putidaredoxin's C-Terminal Amino Acid

K. Suslick, S. Sligar, L. Qin, 1990 .

Glimpsing the Critical Intermediate in Cytochrome P450 Oxidations

S. Sligar, 2010, Science.

Resonance Raman detection of the hydroperoxo intermediate in the cytochrome P450 enzymatic cycle.

S. Sligar, I. Denisov, J. Kincaid, 2007, Journal of the American Chemical Society.