Jiandong Chen

发表

MDM2 Promotes Ubiquitination and Degradation of MDMX

Yu Pan, Jiandong Chen, 2003, Molecular and Cellular Biology.

Phosphorylation and hsp90 Binding Mediate Heat Shock Stabilization of p53*

Jiandong Chen, Chuangui Wang, 2003, The Journal of Biological Chemistry.

Nuclear exclusion of p53 in a subset of tumors requires MDM2 function

Jiandong Chen, Wenge Lu, R. Pochampally, 2000, Oncogene.

MDM2 Acts Downstream of p53 as an E3 Ligase to Promote FOXO Ubiquitination and Degradation*

Pengfei Li, Zheng Shen, S. Nicosia, 2009, Journal of Biological Chemistry.

Interaction between the retinoblastoma protein and the oncoprotein MDM2

W. Sellers, A. Levine, D. Livingston, 1995, Nature.

A 60 kd MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells

Jiandong Chen, R. Pochampally, Lihong Chen, 1998, Oncogene.

Achieving cell penetration with distance-matching cysteine cross-linkers: a facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx.

Jiandong Chen, Qing Lin, Zhiyong Wang, 2011, Chemical communications.

Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX*

Ernst Schönbrunn, Baozong Li, W. Guida, 2009, The Journal of Biological Chemistry.

Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking.

Shen-Shu Sung, Michael J Zaworotko, W. Guida, 2009, Bioorganic & medicinal chemistry letters.

Design and synthesis of AApeptides: a new class of peptide mimics.

Jiandong Chen, S. Sebti, Jianfeng Cai, 2011, Bioorganic & medicinal chemistry letters.

p14(ARF) inhibits the functions of adenovirus E1A oncoprotein.

Yongping Cui, Jiandong Chen, J. Wong, 2011, The Biochemical journal.

ARF inhibits the functions of adenovirus E 1 A oncoprotein

Li Yang, Yongping Cui, L. Xiaotao, 2011 .

Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition.

Michael M. Madden, Qing Lin, Jiandong Chen, 2011, Bioorganic & medicinal chemistry letters.

SirT1 and rRNA in the nucleolus: regulating the regulator

Jiandong Chen, Leixiang Yang, 2014, Oncoscience.

Hypothermia Effectively Treats Tumors with Temperature-Sensitive p53 Mutations

Jiandong Chen, Lihong Chen, Junhao Lu, 2021, Cancer Research.

α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53–MDM2/MDMX Protein–Protein Interactions

Jiandong Chen, G. Daughdrill, Lihong Chen, 2020, Journal of medicinal chemistry.

A Subset of Drosophila Integrator Proteins Is Essential for Efficient U7 snRNA and Spliceosomal snRNA 3′-End Formation

E. Wagner, Jiandong Chen, W. Marzluff, 2010, Molecular and Cellular Biology.

p53 Acetylation Is Crucial for Its Transcription-independent Proapoptotic Functions*

M. Hung, Heng-Huan Lee, H. Yamaguchi, 2009, Journal of Biological Chemistry.

Aurora-A Abrogation of p53 DNA Binding and Transactivation Activity by Phosphorylation of Serine 215*

S. Nicosia, J. Cheng, Jiandong Chen, 2004, Journal of Biological Chemistry.

Activation of p27Kip1 Expression by E2F1

Jiandong Chen, Yihong Ma, W. D. Cress, 2005, Journal of Biological Chemistry.

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage

W. Gu, Jiandong Chen, Yihong Ma, 2006, Nature Cell Biology.

Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity

Jiandong Chen, G. Daughdrill, Lihong Chen, 2020, Oncogene.

Mutant p53 Sequestration of the MDM2 Acidic Domain Inhibits E3 Ligase Activity

Jiandong Chen, Lihong Chen, Leixiang Yang, 2018, Molecular and Cellular Biology.

Functional Analysis of the Integrator Subunit 12 Identifies a Microdomain That Mediates Activation of the Drosophila Integrator Complex*

E. Wagner, Jiandong Chen, W. Warren, 2013, The Journal of Biological Chemistry.

Rational Design of Right-Handed Heterogeneous Peptidomimetics as Inhibitors of Protein-Protein Interactions.

Jiandong Chen, G. Daughdrill, Lihong Chen, 2020, Journal of medicinal chemistry.

Rational Design and Synthesis of Right-Handed D-Sulfono-γ-AApeptide Helical Foldamers as Potent Inhibitors of Protein-Protein Interactions.

Jiandong Chen, G. Daughdrill, Peng Sang, 2020, The Journal of organic chemistry.

Ubiquitous Induction of p53 in Tumor Cells by Antisense Inhibition of MDM2 Expression

Jiandong Chen, Wenge Lu, Lihong Chen, 1999, Molecular medicine.

γ-AApeptides: design, synthesis and evaluation

Jiandong Chen, Y. Niu, Jianfeng Cai, 2011 .

A Subset of Drosophila Integrator Proteins Is Essential for Efﬁcient U7 snRNA and Spliceosomal snRNA 3 (cid:1) -End Formation (cid:1) †

E. Wagner, Jiandong Chen, W. Marzluff, 2010 .

An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3'-end formation.

E. Wagner, Jiandong Chen, W. Marzluff, 2012, RNA.

Two short linear motifs in the MDMX acidic domain bind overlapping sites on MDMX and p53.

Jiandong Chen, G. Daughdrill, Lihong Chen, 2022, Journal of molecular biology.

MDMX inhibits casein kinase 1α activity and stimulates Wnt signaling

Jiandong Chen, Lihong Chen, Qingling Huang, 2020, The EMBO journal.

Tumor-derived CK1α mutations enhance MDMX inhibition of p53

Jiandong Chen, Lihong Chen, Qingling Huang, 2019, Oncogene.

MDM2-ARF complex regulates p53 sumoylation

Jiandong Chen, Lihong Chen, 2003, Oncogene.

Hfq links translation repression to stress-induced mutagenesis in E. coli

S. Gottesman, Jiandong Chen, 2017, Genes & development.

AApeptides as a New Class of Peptidomimetics to Regulate Protein-Protein Interactions

Jiandong Chen, Rongsheng E. Wang, Y. Niu, 2012 .

Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions.

Sukwon Hong, Mark Searcey, Dale L Boger, 2009, Journal of the American Chemical Society.

p53 α-Helix mimetics antagonize p53/MDM2 interaction and activate p53

Jiandong Chen, S. Sebti, Lihong Chen, 2005, Molecular Cancer Therapeutics.

Regulation of Bax Activation and Apoptotic Response to Microtubule-damaging Agents by p53 Transcription-dependent and -independent Pathways*

H. Yamaguchi, K. Bhalla, Jiandong Chen, 2004, Journal of Biological Chemistry.

Ionizing Radiation Exposure Results in Up-regulation of Ku70 via a p53/Ataxia-Telangiectasia-mutated Protein-dependent Mechanism*

Jiandong Chen, J. Giardina, K. Brown, 2000, The Journal of Biological Chemistry.

The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression.

Jiandong Chen, 2016, Cold Spring Harbor perspectives in medicine.

SIRT1 Negatively Regulates the Activities, Functions, and Protein Levels of hMOF and TIP60

William Arbuthnot Sir Lane, Jiandong Chen, E. Seto, 2012, Molecular and Cellular Biology.

Transcriptional Repression of the Anti-apoptoticsurvivin Gene by Wild Type p53*

Jiandong Chen, M. Murphy, W. Hoffman, 2002, The Journal of Biological Chemistry.

Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding

Jiandong Chen, G. Daughdrill, Lihong Chen, 2019, Proceedings of the National Academy of Sciences.

ATM activates p53 by regulating MDM2 oligomerization and E3 processivity

William Arbuthnot Sir Lane, Jiandong Chen, Lihong Chen, 2009, The EMBO journal.

Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells.

Jiandong Chen, S. Melmed, Wenge Lu, 2003, Endocrinology.

HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα.

G. Bepler, S. Nicosia, Amanda E. Jones, 2014, Molecular cell.

Abstract 3090: Inhibition of p53 DNA binding function by the MDM2 acidic domain

Zhi-Min Yuan, Jiandong Chen, Bao-zong Li, 2011 .

Inhibition of p53 DNA Binding Function by the MDM2 Protein Acidic Domain*

Zhi-Min Yuan, Jiandong Chen, Lihong Chen, 2011, The Journal of Biological Chemistry.

Inhibition of p 53 DNA binding function by the MDM 2 acidic domain

Zhi-Min Yuan, Jiandong Chen, Lihong Chen, 2011 .

A fluorescence-based genetic screen reveals diverse mechanisms silencing small RNA signaling in E. coli

N. Majdalani, S. Gottesman, Jiandong Chen, 2021, Proceedings of the National Academy of Sciences.

SIRT1 Deacetylates the DNA Methyltransferase 1 (DNMT1) Protein and Alters Its Activities

William Arbuthnot Sir Lane, Jiandong Chen, K. Robertson, 2011, Molecular and Cellular Biology.

Activation of an MDM2-specific Caspase by p53 in the Absence of Apoptosis*

Jiandong Chen, Wenge Lu, R. Pochampally, 1999, The Journal of Biological Chemistry.

SHP2E76K mutant promotes lung tumorigenesis in transgenic mice.

Yuan Ren, Eric B Haura, Domenico Coppola, 2014, Carcinogenesis.

Regulation of MDMX nuclear import and degradation by Chk2 and 14‐3‐3

Jiandong Chen, Daniele M. Gilkes, Lihong Chen, 2006, The EMBO journal.

Proteolytic Cleavage of the mdm2 Oncoprotein during Apoptosis*

A. Levine, Jiandong Chen, V. Maréchal, 1997, The Journal of Biological Chemistry.

Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene

A. Levine, Jiandong Chen, Jiayuh Lin, 1995, Molecular medicine.

Molecular Abnormalities of mdm 2 and p 53 Genes in Adult Soft Tissue Sarcomas '

A. Levine, C. Cordon-Cardo, Jiandong Chen, 2022 .

Functional Analysis of Drosophila Integrator Complex in snRNA 3' End Processing

Jiandong Chen, 2012 .

MDMX Overexpression Prevents p53 Activation by the MDM2 Inhibitor Nutlin*

Baoli Hu, Baoli Hu, Jiandong Chen, 2006, Journal of Biological Chemistry.

Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX.

Baoli Hu, Jiandong Chen, Daniele M. Gilkes, 2007, Cancer research.

Tumor cell senescence response produces aggressive variants

Jiandong Chen, Jia Fang, Leixiang Yang, 2017, Cell Death Discovery.

Ubiquitinated Sirtuin 1 (SIRT1) Function Is Modulated during DNA Damage-induced Cell Death and Survival*

Jiandong Chen, E. Seto, K. Fukasawa, 2015, The Journal of Biological Chemistry.

Nucleolar repression facilitates initiation and maintenance of senescence

Jiandong Chen, Lihong Chen, H. Soliman, 2015, Cell cycle.

p53 promotes repair of heterochromatin DNA by regulating JMJD2b and SUV39H1 expression

Jiandong Chen, Lihong Chen, W. J. Pledger, 2013, Oncogene.

MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output

T. Jenuwein, Zhi-Min Yuan, Jiandong Chen, 2010, The EMBO journal.

MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output

T. Jenuwein, Zhi-Min Yuan, Jiandong Chen, 2010, The EMBO journal.

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation

Jiandong Chen, Chuangui Wang, E. Seto, 2005, The EMBO journal.

MDMX acidic domain inhibits p53 DNA binding in vivo and regulates tumorigenesis

J. Cleveland, Jiandong Chen, Lihong Chen, 2018, Proceedings of the National Academy of Sciences.

Intra molecular interactions in the regulation of p53 pathway.

Jiandong Chen, 2016, Translational cancer research.

Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding

Jiandong Chen, G. Daughdrill, Lihong Chen, 2016, Proceedings of the National Academy of Sciences.

Autoactivation of the MDM2 E3 Ligase by Intramolecular Interaction

Jiandong Chen, Lihong Chen, T. Song, 2014, Molecular and Cellular Biology.

Phosphorylation of Daxx by ATM Contributes to DNA Damage-Induced p53 Activation

Jiandong Chen, Xiaolu Yang, Like Qu, 2013, PloS one.

The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53.

Jiandong Chen, 2012, Genes & cancer.

Regulation of MDM2 E3 Ligase Activity by Phosphorylation after DNA Damage

Jiandong Chen, Lihong Chen, Bao-zong Li, 2011, Molecular and Cellular Biology.

The phenotype of MDM2 auto-degradation after DNA damage is due to epitope masking by phosphorylation

Jiandong Chen, Qian Cheng, 2011, Cell cycle.

Rescue of mutant p53 transcription function by ellipticine

Jiandong Chen, S. Sebti, Lihong Chen, 2003, Oncogene.

Inhibition of MDM2 by hsp90 Contributes to Mutant p53 Stabilization*

Jiandong Chen, Wenge Lu, Lihong Chen, 2001, The Journal of Biological Chemistry.

Stabilization of the MDM2 Oncoprotein by Mutant p53*

Jiandong Chen, Wenge Lu, Lihong Chen, 2001, The Journal of Biological Chemistry.

Expression of p14ARF overcomes tumor resistance to p53.

Jiandong Chen, Jiayuh Lin, Wenge Lu, 2002, Cancer research.

Discovery and initial characterization of YloC, a novel endoribonuclease in Bacillus subtilis

D. Bechhofer, Jiandong Chen, Shivani Chhabra, 2021, RNA.

snRNA 3' end formation: the dawn of the Integrator complex.

E. Wagner, Jiandong Chen, 2010, Biochemical Society transactions.

Conjugation of spermine enhances cellular uptake of the stapled peptide-based inhibitors of p53-Mdm2 interaction.

Jiandong Chen, Qing Lin, Avinash Muppidi, 2011, Bioorganic & medicinal chemistry letters.

Activation of p53 by roscovitine-mediated suppression of MDM2 expression

Jiandong Chen, Wenge Lu, Lihong Chen, 2001, Oncogene.

SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress

S. Nicosia, K. Bhalla, Jiandong Chen, 2007, Nature Cell Biology.

Distinct Roles of MDMX in the Regulation of p53 Response to Ribosomal Stress

Jiandong Chen, Daniele M. Gilkes, 2007, Cell cycle.

MPP8 and SIRT1 crosstalk in E‐cadherin gene silencing and epithelial–mesenchymal transition

Jiandong Chen, E. Seto, Lidong Sun, 2015, EMBO reports.

MPP 8 and SIRT 1 crosstalk in E-cadherin gene silencing and epithelial – mesenchymal transition

Jiandong Chen, E. Seto, Lidong Sun, 2015 .

Pituitary Tumor Transforming Gene Causes Aneuploidy and p53-dependent and p53-independent Apoptosis*

Jiandong Chen, S. Melmed, Wenge Lu, 2000, The Journal of Biological Chemistry.

ATM and Chk2‐dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

William Arbuthnot Sir Lane, Yu Pan, Jiandong Chen, 2005, The EMBO journal.

sRNA-Mediated Control of Transcription Termination in E. coli

S. Gottesman, Jiandong Chen, E. Nudler, 2016, Cell.

MDMX regulation of p53 response to ribosomal stress

Jiandong Chen, Daniele M. Gilkes, Lihong Chen, 2006, The EMBO journal.

Mechanism of p53 stabilization by ATM after DNA damage

Jiandong Chen, Qian Cheng, 2010, Cell cycle.

Regulation of MDMX Expression by Mitogenic Signaling

T. Yeatman, D. Coppola, Yu Pan, 2008, Molecular and Cellular Biology.

Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX.

Baoli Hu, Jiandong Chen, Daniele M. Gilkes, 2007, Cancer research.

Regulation of SirT1-Nucleomethylin Binding by rRNA Coordinates Ribosome Biogenesis with Nutrient Availability

Jiandong Chen, E. Seto, Lihong Chen, 2013, Molecular and Cellular Biology.

p53 alpha-Helix mimetics antagonize p53/MDM2 interaction and activate p53.

Jiandong Chen, S. Sebti, Lihong Chen, 2005, Molecular cancer therapeutics.

Casein Kinase 1α Regulates an MDMX Intramolecular Interaction To Stimulate p53 Binding

A. Becker, Jiandong Chen, Lihong Chen, 2012, Molecular and Cellular Biology.

CARPs enhance p53 turnover by degrading 14-3-3σ and stabilizing MDM2

W. El-Deiry, D. Dicker, Jiandong Chen, 2008 .

Abnormal MDMX degradation in tumor cells due to ARF deficiency

Jiandong Chen, Daniele M. Gilkes, Bao-zong Li, 2011, Oncogene.

Mappingofthep53andmdm-2Interaction Domains

Jiandong Chen, V. Maréchal, 1993 .

Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain.

Jiandong Chen, E. Schönbrunn, Lihong Chen, 2022, Journal of medicinal chemistry.

Optimal Affinity Enhancement by a Conserved Flexible Linker Controls p53 Mimicry in MdmX.

A. Becker, Jiandong Chen, G. Daughdrill, 2017, Biophysical journal.

The ATDC (TRIM29) Protein Binds p53 and Antagonizes p53-Mediated Functions

D. Coppola, William Arbuthnot Sir Lane, Jiandong Chen, 2010, Molecular and Cellular Biology.

Inhibition of SUV39H1 Methyltransferase Activity by DBC1*

Jiandong Chen, Chuangui Wang, Lihong Chen, 2009, Journal of Biological Chemistry.

Regulation of E2F1 Function by the Nuclear Corepressor KAP1*

Jiandong Chen, W. D. Cress, Chuangui Wang, 2007, Journal of Biological Chemistry.

Limitations of Peptide Retro-inverso Isomerization in Molecular Mimicry*

Jiandong Chen, Chong Li, M. Pazgier, 2010, The Journal of Biological Chemistry.

Regulation of p53-MDMX Interaction by Casein Kinase 1 Alpha

Yu Pan, Jiandong Chen, Lihong Chen, 2005, Molecular and Cellular Biology.

Siderophore piracy enhances Vibrio cholerae environmental survival and pathogenesis.

Jiandong Chen, Jay Zhu, I-Ji Jung, 2020, Microbiology.

SirT1 Is an Inhibitor of Proliferation and Tumor Formation in Colon Cancer*

T. Yeatman, D. Coppola, Jiandong Chen, 2009, The Journal of Biological Chemistry.

The NAD+ Synthesis Enzyme Nicotinamide Mononucleotide Adenylyltransferase (NMNAT1) Regulates Ribosomal RNA Transcription*

Jiandong Chen, Lihong Chen, E. Haura, 2013, The Journal of Biological Chemistry.

Autoinhibition of MDMX by intramolecular p53 mimicry

A. Becker, Jiandong Chen, G. Daughdrill, 2015, Proceedings of the National Academy of Sciences.

p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors

Jiandong Chen, Bao-zong Li, Zhenyu Li, 2010, Cell cycle.

Deregulated expression of LRBA facilitates cancer cell growth

T. Yeatman, Tien-chi Pan, A. Ramne, 2004, Oncogene.

Correction: Phosphorylation of Daxx by ATM Contributes to DNA Damage-Induced p53 Activation

Jiandong Chen, Xiaolu Yang, Like Qu, 2013, PLoS ONE.

Regulation of Transcription Termination of Small RNAs and by Small RNAs: Molecular Mechanisms and Biological Functions

S. Gottesman, Jiandong Chen, T. Morita, 2019, Front. Cell. Infect. Microbiol..

Efficient synthesis of a beta-peptide combinatorial library with microwave irradiation.

Lloyd M. Smith, M. Scalf, S. Gellman, 2005, Journal of the American Chemical Society.

DNA Damage Induces MDMX Nuclear Translocation by p53-Dependent and -Independent Mechanisms

Jiandong Chen, Lihong Chen, Changgong Li, 2002, Molecular and Cellular Biology.

hMOF Acetylation of DBC1/CCAR2 Prevents Binding and Inhibition of SirT1

Jiandong Chen, E. Seto, Hong Zheng, 2013, Molecular and Cellular Biology.

Spot 42 Small RNA Regulates Arabinose-Inducible araBAD Promoter Activity by Repressing Synthesis of the High-Affinity Low-Capacity Arabinose Transporter

S. Gottesman, Jiandong Chen, Susan Gottesman, 2016, Journal of bacteriology.

Bing De Ling, a Chinese herbal formula, inhibits cancer cells growth via p53.

S. Nicosia, Jiandong Chen, Shengyan Xiang, 2010, Frontiers in bioscience.

Riboswitch regulates RNA

S. Gottesman, Jiandong Chen, 2014, Science.

Thiol-based functional mimicry of phosphorylation of the two-component system response regulator ArcA promotes pathogenesis in enteric pathogens

Yitian Zhou, Jiandong Chen, M. Goulian, 2021, Cell reports.

Modification of MDMX by sumoylation.

Yu Pan, Jiandong Chen, 2005, Biochemical and biophysical research communications.

Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas.

A. Levine, C. Cordon-Cardo, M. Drobnjak, 1994, Cancer research.

mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

A. Levine, Jiandong Chen, Jiayuh Lin, 1996, Molecular and cellular biology.

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.

A. Levine, Jiandong Chen, B. Elenbaas, 1994, Genes & development.

Advances in Brief Expression of p 14 ARF Overcomes Tumor Resistance to p 531

Jiandong Chen, Jiayuh Lin, Wenge Lu, 2002 .

Deacetylation of cortactin by SIRT1 promotes cell migration

P. Kruk, S. Nicosia, J. Cheng, 2009, Oncogene.

Synergistic activation of p 53 by inhibition of MDM 2 expression and DNA damage

Jiandong Chen, Lihong Chen, S. Agrawal, 1997 .

Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage.

Jiandong Chen, Lihong Chen, S. Agrawal, 1998, Proceedings of the National Academy of Sciences of the United States of America.

SHP2E76K mutant promotes lung tumorigenesis in transgenic mice.

D. Coppola, Yuan Ren, Jie Wu, 2014, Carcinogenesis.

Nucleolar repression facilitates initiation and maintenance of senescence

Jiandong Chen, Lihong Chen, H. Soliman, 2015, Cell cycle.