H. Jaeschke

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Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

Mitchell R. McGill, H. Jaeschke, A. Ramachandran, 2012, Drug metabolism reviews.

Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice

H. Jaeschke, A. Ramachandran, Nga T. Nguyen, 2021, Archives of Toxicology.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Adam S. Hayward, C. Meyer, S. Dooley, 2013, Archives of Toxicology.

Cytokine‐induced upregulation of hepatic intercellular adhesion molecule‐1 messenger RNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure

H. Jaeschke, A. Manning, N. Essani, 1995, Hepatology.

Osteopontin is an initial mediator of inflammation and liver injury during obstructive cholestasis after bile duct ligation in mice.

Hartmut Jaeschke, H. Jaeschke, A. Ramachandran, 2014, Toxicology letters.

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity.

Mitchell R. McGill, Dominic P. Williams, J. Dear, 2012, Journal of hepatology.

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation.

Hartmut Jaeschke, Mitchell R. McGill, H. Jaeschke, 2012, The Journal of clinical investigation.

Assessment of the Biochemical Pathways for Acetaminophen Toxicity: Implications for its Carcinogenic Hazard Potential.

Samuel M. Cohen, H. Jaeschke, E. Kuffner, 2020, Regulatory toxicology and pharmacology : RTP.

Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice

H. Jaeschke, W. Ding, Hua Sun, 2021, Liver research.

Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice

R. Dobrowsky, H. Jaeschke, W. Ding, 2019, Redox biology.

Chlorpromazine protects against acetaminophen-induced liver injury in mice by modulating autophagy and c-Jun N-terminal kinase activation☆

H. Jaeschke, W. Ding, Yuan Li, 2019, Liver research.

Role and mechanisms of autophagy in acetaminophen‐induced liver injury

H. Jaeschke, W. Ding, Hua Wang, 2018, Liver international : official journal of the International Association for the Study of the Liver.

A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen.

Mitchell R. McGill, H. Jaeschke, B. Fromenty, 2016, Toxicology and applied pharmacology.

Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice.

Mitchell R. McGill, H. Jaeschke, J. Luyendyk, 2015, Blood.

Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.

Mitchell R. McGill, H. Jaeschke, Prachi Borude, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Pleiotropic Role of p53 in Injury and Liver Regeneration after Acetaminophen Overdose.

H. Jaeschke, Prachi Borude, B. Bhushan, 2018, The American journal of pathology.

Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration.

Mitchell R. McGill, H. Jaeschke, Stefanie Kennon-McGill, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Disruption of Estrogen Receptor Alpha in Rats Results in Faster Initiation of Compensatory Regeneration Despite Higher Liver Injury After Carbon Tetrachloride Treatment

Hartmut Jaeschke, Udayan Apte, H. Jaeschke, 2017, International journal of toxicology.

Connexin32: a mediator of acetaminophen-induced liver injury?

Mitchell R. McGill, M. Maes, M. Vinken, 2016, Toxicology mechanisms and methods.

Toxicant-Induced Liver Injury

H. Jaeschke, 2011 .

Mechanisms of Acetaminophen Hepatotoxicity

H. Jaeschke, M. Bajt, 2010 .

Plasminogen activator inhibitor-1 limits liver injury and facilitates regeneration after acetaminophen overdose.

H. Jaeschke, A. Farhood, Hui-min Yan, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Role of inflammation in the mechanism of acetaminophen-induced hepatotoxicity

H. Jaeschke, 2005, Expert opinion on drug metabolism & toxicology.

The role of MLKL in Hepatic Ischemia-Reperfusion Injury of Alcoholic Steatotic Livers

H. Jaeschke, W. Ding, H. Ni, 2022, International journal of biological sciences.

Reduced inflammatory response and increased microcirculatory disturbances during hepatic ischemia-reperfusion injury in steatotic livers of ob/ob mice.

H. Jaeschke, R. McCuskey, Jie Liu, 2007, American journal of physiology. Gastrointestinal and liver physiology.

mice ob/ob ischemia-reperfusion injury in steatotic livers of microcirculatory disturbances during hepatic Reduced inflammatory response and increased

H. Jaeschke, R. McCuskey, Jie Liu, 2007 .

The importance of leptin in mice and man

H. Jaeschke, R. McCuskey, 2004 .

Environmental Liver Toxins

H. Jaeschke, A. Ramachandran, J. Akakpo, 2019, Encyclopedia of Environmental Health.

Neutrophil-induced liver cell injury in endotoxin shock is a CD11b/CD18-dependent mechanism.

C. Smith, H. Jaeschke, A. Farhood, 1991, The American journal of physiology.

Complement activates Kupffer cells and neutrophils during reperfusion after hepatic ischemia.

H. Jaeschke, J. Spitzer, A. Farhood, 1993, The American journal of physiology.

Complement and tumor necrosis factor‐α contribute to Mac‐1 (CD11b/CD18) up‐regulation and systemic neutrophil activation during endotoxemia in vivo

C. Smith, H. Jaeschke, A. Farhood, 1994, Journal of leukocyte biology.

Pathophysiologic importance of E‐ and L‐selectin for neutrophil‐induced liver injury during endotoxemia in mice

H. Jaeschke, A. Burns, A. Farhood, 2000, Hepatology.

Critical Factors in the Assessment of Cholestatic Liver Injury In Vitro.

H. Jaeschke, B. Woolbright, 2015, Methods in molecular biology.

Oxidative Stress and the Pathogenesis of Cholestasis

H. Jaeschke, B. Copple, C. Klaassen, 2010, Seminars in liver disease.

Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis.

H. Jaeschke, B. Copple, Katryn Allen, 2011, The American journal of pathology.

Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice.

K. Zatloukal, H. Denk, H. Jaeschke, 2006, The American journal of pathology.

Chemokines, neutrophils, and inflammatory liver injury.

H. Jaeschke, 1996, Shock.

Cellular adhesion molecules: regulation and functional significance in the pathogenesis of liver diseases.

H. Jaeschke, 1997, The American journal of physiology.

Role of PECAM-1 (CD31) in neutrophil transmigration in murine models of liver and peritoneal inflammation.

C. J. Dunn, H. Jaeschke, M. Fisher, 1998, American journal of physiology. Gastrointestinal and liver physiology.

Proteomics Indicates that Lactate Dehydrogenase is Prognostic in Acetaminophen-induced Acute Liver Failure Patients and Reveals a Role for LKB1-AMPK Signaling

Mitchell R. McGill, Stephanie D. Byrum, J. Dranoff, 2021, medRxiv.

Manipulation of mouse organ glutathione contents I: Enhancement by oral administration of butylated hydroxyanisole and butylated hydroxytoluene.

H. Jaeschke, A. Wendel, 1985, Toxicology.

Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and fas‐antibody–induced liver injury

H. Jaeschke, M. Fisher, A. Farhood, 1998, Hepatology.

Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms

Glen E. P. Ropella, Mitchell R. McGill, C. Hunt, 2020, PLoS computational biology.

Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation.

H. Jaeschke, A. Farhood, C. Williams, 2011, Toxicology and applied pharmacology.

Innate immunity and acetaminophen‐induced liver injury: Why so many controversies?

H. Jaeschke, 2008, Hepatology.

INFLAMMATION AND CELL DEATH DURING CHOLESTASIS: THE EVOLVING ROLE OF BILE ACIDS.

H. Jaeschke, B. Woolbright, 2019, Gene expression.

STAT-3 and the liver: a New STATion on Our Way to Understand Diabetes? regulation and

H. Jaeschke, 2005 .

Ischemia-reperfusion activates the nuclear transcription factor NF-κB and upregulates messenger RNA synthesis of adhesion molecules in the liver in vivo

H. Jaeschke, A. Manning, N. Essani, 1997 .

Antioxidant Defense Mechanisms

H. Jaeschke, 2010 .

Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury.

H. Jaeschke, A. Ramachandran, A. Farhood, 2015, Toxicology and applied pharmacology.

Multiple scan modes in the hybrid tandem mass spectrometric screening and characterization of the glutathione conjugate of 2-furamide

H. Jaeschke, S. Gaskell, M. Raftery, 1991, Journal of the American Society for Mass Spectrometry.

A mitochondrial journey through acetaminophen hepatotoxicity.

H. Jaeschke, A. Ramachandran, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Acetaminophen hepatotoxicity: A mitochondrial perspective.

H. Jaeschke, A. Ramachandran, 2019, Advances in pharmacology.

Invited Review Acetaminophen Toxicity: Novel Insights Into Mechanisms and Future Perspectives

H. Jaeschke, A. Ramachandran, 2018 .

Pathophysiological relevance of proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.

Mitchell R. McGill, H. Jaeschke, A. Ramachandran, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

The Challenge of Drug-Induced Liver Injury (DILI) / Challenges and Management of Liver Cirrhosis: The Challenge of Drug-Induced Liver Injury (DILI) Falk Workshop, Freiburg, October 2014 Challenges and Management of Liver Cirrhosis Falk Symposium 195, Freiburg, October 2014

H. Jaeschke, A. Gerbes, M. Pinzani, 2015 .

Effect of bile duct ligation on bile acid composition in mouse serum and liver

H. Jaeschke, B. Copple, Ji-Young Hong, 2012, Liver international : official journal of the International Association for the Study of the Liver.

24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice.

K. Zatloukal, H. Denk, H. Jaeschke, 2006, Gastroenterology.

Release of soluble intercellular adhesion molecule 1 into bile and serum in murine endotoxin shock

C. Smith, H. Jaeschke, N. Essani, 1996, Hepatology.

INHIBITION OF NF‐KB ACTIVATION BY DIMETHYL SULFOXIDE CORRELATES WITH SUPPRESSION OF TNF‐α FORMATION, REDUCED ICAM‐1 GENE TRANSCRIPTION, AND PROTECTION AGAINST ENDOTOXIN‐INDUCED LIVER INJURY

H. Jaeschke, N. Essani, M. Fisher, 1997 .

Monoclonal antibody against the CD18 adhesion molecule stimulates glucose uptake by the liver and hepatic nonparenchymal cells

C. Smith, H. Jaeschke, J. Spitzer, 1993, Hepatology.

Hepatic Responses to Bacterial Endotoxin (LPS)

H. Jaeschke, J. Spitzer, I. Deaciuc, 1993 .

Structure, Regulation and Function of Gap Junctions in Liver

M. Maes, M. Vinken, H. Jaeschke, 2015, Cell communication & adhesion.

Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice*

H. Jaeschke, W. Ding, Yuan Li, 2015, The Journal of Biological Chemistry.

Xanthine oxidase–induced oxidant stress during hepatic ischemia‐reperfusion: Are we coming full circle after 20 years?

H. Jaeschke, 2002, Hepatology.

Reactive oxygen and ischemia/reperfusion injury of the liver.

H. Jaeschke, H. Jaeschke, 1991, Chemico-biological interactions.

Generation and functional significance of CXC chemokines for neutrophil-induced liver injury during endotoxemia.

H. Jaeschke, A. Farhood, M. Bajt, 2005, American journal of physiology. Gastrointestinal and liver physiology.

Antioxidant Defense in Liver Injury: Oxidant Stress, Antioxidant Defense and Liver Injury

H. Jaeschke, 2007 .

Fructose Protects Against Acetaminophen‐Induced Hepatotoxicity Mainly by Activating the Carbohydrate‐Response Element‐Binding Protein α–Fibroblast Growth Factor 21 Axis in Mice

P. Saha, H. Jaeschke, L. Yin, 2021, Hepatology communications.

Novel Therapeutic Approaches against Acetaminophen-induced Liver Injury and Acute Liver Failure.

H. Jaeschke, A. Ramachandran, David S. Umbaugh, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

The role of acrolein in allyl alcohol-induced lipid peroxidation and liver cell damage in mice.

H. Jaeschke, A. Wendel, C. Kleinwaechter, 1987, Biochemical pharmacology.

Neutrophil margination and extravasation in sinusoids and venules of liver during endotoxin-induced injury.

C. J. Dunn, H. Jaeschke, N. Essani, 1997, The American journal of physiology.

FORUM Mechanisms of Hepatotoxicity

G. Gores, H. Jaeschke, D. Pessayre, 2002 .

Role of nitric oxide in the oxidant stress during ischemia/reperfusion injury of the liver.

H. Jaeschke, A. Farhood, V. Schini, 1992, Life sciences.

Drug-induced lipid peroxidation in mice--III. Glutathione content of liver, kidney and spleen after intravenous administration of free and liposomally entrapped glutathione.

H. Jaeschke, A. Wendel, 1982, Biochemical Pharmacology.

Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity.

H. Jaeschke, A. Ramachandran, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Sortilin 1 Loss-of-Function Protects Against Cholestatic Liver Injury by Attenuating Hepatic Bile Acid Accumulation in Bile Duct Ligated Mice

H. Jaeschke, Tiangang Li, B. Woolbright, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Mechanism of protection by metallothionein against acetaminophen hepatotoxicity.

H. Jaeschke, A. Artigues, M. Villar, 2010, Toxicology and applied pharmacology.

Translocation of iron from lysosomes to mitochondria during acetaminophen-induced hepatocellular injury: Protection by starch-desferal and minocycline.

H. Jaeschke, J. Lemasters, C. Beeson, 2016, Free radical biology & medicine.

A direct comparison of methods used to measure oxidized glutathione in biological samples: 2-vinylpyridine and N-ethylmaleimide

Mitchell R. McGill, H. Jaeschke, 2015, Toxicology mechanisms and methods.

Alcoholic Hepatitis: Lost in Translation

H. Jaeschke, B. Woolbright, 2017, Journal of clinical and translational hepatology.

Manipulation of mouse organ glutathione contents. II: Time and dose-dependent induction of the glutathione conjugation system by phenolic antioxidants.

H. Jaeschke, A. Wendel, 1986, Toxicology.

Biomarkers of drug-induced liver injury.

Mitchell R. McGill, H. Jaeschke, Mitch McGill, 2019, Advances in pharmacology.

Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

Hartmut Jaeschke, H. Jaeschke, A. Ramachandran, 2012, Liver international : official journal of the International Association for the Study of the Liver.

Generation of Pro- and Anti-Inflammatory Mediators after Acetaminophen Overdose in Surviving and Non-Surviving Patients.

Mitchell R. McGill, H. Jaeschke, Nga T. Nguyen, 2022, Toxicology letters.

Oxidant Stress and Lipid Peroxidation in Acetaminophen Hepatotoxicity.

H. Jaeschke, A. Ramachandran, 2018, Reactive oxygen species.

Mechanisms of Inflammatory Liver Injury and Drug-Induced Hepatotoxicity

H. Jaeschke, B. Woolbright, 2018, Current Pharmacology Reports.

Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis.

H. Jaeschke, K. Dorko, S. Kumer, 2015, Toxicology and applied pharmacology.

Early Biomarkers of Hepatocyte Necrosis

Mitchell R. McGill, H. Jaeschke, 2015 .

Pathophysiological relevance of neutrophils in acetaminophen hepatotoxicity

Mitchell R. McGill, H. Jaeschke, C. Williams, 2013, Hepatology.

Comment on “Cyclophilin A Is a Damage-Associated Molecular Pattern Molecule That Mediates Acetaminophen-Induced Liver Injury”

H. Jaeschke, C. Williams, 2011, The Journal of Immunology.

Antineutrophil monoclonal antibody (1F12) alters superoxide anion release by neutrophils and Kupffer cells

C. Smith, H. Jaeschke, J. Spitzer, 1994, Journal of leukocyte biology.

Diurnal fluctuation and pharmacological alteration of mouse organ glutathione content.

H. Jaeschke, A. Wendel, 1985, Biochemical pharmacology.

The answer: angiotensin II. The question: what do inflammation, oxidant stress and fibrogenesis have in common?

C. Trautwein, R. Bataller, J. Boyer, 2004 .

Glutathione disulfide as index of oxidant stress in rat liver during hypoxia.

H. Jaeschke, 1990, The American journal of physiology.

Mass spectrometric quantification of cysteine-containing leukotrienes in rat bile using 13C-labeled internal standards.

H. Jaeschke, S. Gaskell, M. Raftery, 1992, Biological mass spectrometry.

Hepatic sinusoidal cells in health and disease: update from the 14th International Symposium

H. Jaeschke, B. Smedsrød, D. L. Le Couteur, 2009, Liver international : official journal of the International Association for the Study of the Liver.

Therapeutic targets for cholestatic liver injury

H. Jaeschke, B. Woolbright, 2016, Expert opinion on therapeutic targets.

Reactive oxygen species during ischemia-reflow injury in isolated perfused rat liver.

C. V. Smith, H. Jaeschke, J. Mitchell, 1988, The Journal of clinical investigation.

Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy.

H. Jaeschke, B. Copple, J. Luyendyk, 2014, Journal of hepatology.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Protection against TNF-induced liver parenchymal cell apoptosis during endotoxemia by a novel caspase inhibitor in mice.

H. Jaeschke, A. Farhood, B. Tseng, 2000, Toxicology and applied pharmacology.

Bile Acid‐Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes

Mitchell R. McGill, H. Jaeschke, Hui-min Yan, 2016, Basic & clinical pharmacology & toxicology.

Role of reactive oxygen species for hepatocellular injury and heme oxygenase-1 gene expression after hemorrhage and resuscitation.

H. Jaeschke, M. Silomon, M. Bauer, 1999, Shock.

Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts.

K. Zatloukal, H. Denk, H. Jaeschke, 2009, The American journal of pathology.

Lithocholic acid feeding results in direct hepato-toxicity independent of neutrophil function in mice.

H. Jaeschke, M. Trauner, Feng Li, 2014, Toxicology letters.

Gender-specific reduction of hepatic Mrp2 expression by high-fat diet protects female mice from ANIT toxicity.

H. Jaeschke, Xiaochao Ma, C. Klaassen, 2012, Toxicology and applied pharmacology.

Hepatobiliary Transporter Expression in Intercellular Adhesion Molecule 1 Knockout and Fas Receptor-Deficient Mice after Common Bile Duct Ligation Is Independent of the Degree of Inflammation and Oxidative Stress

K. Zatloukal, H. Denk, H. Jaeschke, 2007, Drug Metabolism and Disposition.

Multistep processes in neutrophil homotypic aggregation and tissue injury

S. Simon, C. Smith, H. Jaeschke, 1999 .

Gastrointestinal , Hepatobiliary and Pancreatic Pathology The BH 3-Only Protein Bid Does Not Mediate Death-Receptor-Induced Liver Injury in Obstructive Cholestasis

M. Manns, H. Jaeschke, Ji-Young Hong, 2010 .

The BH3-only protein bid does not mediate death-receptor-induced liver injury in obstructive cholestasis.

M. Manns, H. Jaeschke, Ji-Young Hong, 2009, The American journal of pathology.

Inflammation in response to hepatocellular apoptosis

H. Jaeschke, 2002 .

Biomarkers of drug-induced liver injury: a mechanistic perspective through acetaminophen hepatotoxicity

H. Jaeschke, David S. Umbaugh, 2020, Expert review of gastroenterology & hepatology.

Antioxidant gene therapy and hepatic ischemia‐reperfusion injury

H. Jaeschke, 2002, Hepatology.

Hypoxic damage generates reactive oxygen species in isolated perfused rat liver.

C. V. Smith, H. Jaeschke, J. Mitchell, 1988, Biochemical and biophysical research communications.

Interactions Between Nuclear Receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice.

H. Jaeschke, S. Zeisel, Swetha Rudraiah, 2015, Gastroenterology.

Involvement of connexin43 in acetaminophen-induced liver injury.

Mitchell R. McGill, M. Maes, M. Vinken, 2016, Biochimica et biophysica acta.

Reactive oxygen and mechanisms of inflammatory liver injury

H. Jaeschke, 2000, Journal of gastroenterology and hepatology.

Desorption Electrospray Ionization Mass Spectrometry Imaging Allows Spatial Localization of Changes in Acetaminophen Metabolism in the Liver after Intervention with 4-Methylpyrazole.

H. Jaeschke, A. Ramachandran, A. Artigues, 2022, Journal of the American Society for Mass Spectrometry.

Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury.

Dominic P. Williams, H. Jaeschke, B. K. Park, 2011, Toxicology and applied pharmacology.

Mechanisms and pathophysiological implications of sinusoidal endothelial cell gap formation following treatment with galactosamine/endotoxin in mice.

H. Jaeschke, R. McCuskey, M. K. McCuskey, 2006, American journal of physiology. Gastrointestinal and liver physiology.

Endotoxin-induced activation of the nuclear transcription factor kappa B and expression of E-selectin messenger RNA in hepatocytes, Kupffer cells, and endothelial cells in vivo.

H. Jaeschke, A. Manning, N. Essani, 1996, Journal of immunology.

Inhibition of NF-kappa B activation by dimethyl sulfoxide correlates with suppression of TNF-alpha formation, reduced ICAM-1 gene transcription, and protection against endotoxin-induced liver injury.

H. Jaeschke, N. Essani, M. Fisher, 1997, Shock.

The Inflammatory Response After Hepatic Ischemia/Reperfusion

H. Jaeschke, 2020 .

Mitochondrial Dynamics in Drug-Induced Liver Injury

H. Jaeschke, A. Ramachandran, David S. Umbaugh, 2021, Livers.

Lysosomal Instability and Cathepsin B Release during Acetaminophen Hepatotoxicity

Mitchell R. McGill, H. Jaeschke, A. Ramachandran, 2012, Basic & clinical pharmacology & toxicology.

Pathophysiological consequences of enhanced intracellular superoxide formation in isolated perfused rat liver.

H. Jaeschke, A. E. Benzick, H. Jaeschke, 1992, Chemico-biological interactions.

NADH-dependent reductive stress and ferritin-bound iron in allyl alcohol-induced lipid peroxidation in vivo: the protective effect of vitamin E.

H. Jaeschke, A. Wendel, C. Kleinwaechter, 1992, Chemico-biological interactions.

The pathophysiological significance of reactive oxygen formation in rat liver.

C. V. Smith, H. Jaeschke, J. Mitchell, 1991, Advances in experimental medicine and biology.

Correction to: Direct Amplification of Tissue Factor:Factor VIIa Procoagulant Activity by Bile Acids Drives Intrahepatic Coagulation.

H. Jaeschke, J. Luyendyk, M. Olyaee, 2019, Arteriosclerosis, thrombosis, and vascular biology.

Reactive oxygen as modulator of TNF and fas receptor-mediated apoptosis in vivo: studies with glutathione peroxidase-deficient mice.

H. Jaeschke, Y. Ho, S. Vonderfecht, 2002, Antioxidants & redox signaling.

Differential protection with inhibitors of caspase-8 and caspase-3 in murine models of tumor necrosis factor and Fas receptor-mediated hepatocellular apoptosis.

H. Jaeschke, S. Vonderfecht, M. Bajt, 2001, Toxicology and applied pharmacology.

Vascular oxidant stress and hepatic ischemia/reperfusion injury.

H. Jaeschke, Hartmut Jaeschke, 1991, Free radical research communications.

Human Wharton's Jelly-derived mesenchymal stem cells prevent acetaminophen-induced liver injury in a mouse model unlike human dermal fibroblasts

H. Jaeschke, A. Ramachandran, U. Apte, 2022, Archives of Toxicology.

Role of leukotriene B4 in the pathogenesis of hepatic ischemia-reperfusion injury in the rat.

H. Jaeschke, A. Farhood, H. Hughes, 1992, Prostaglandins, leukotrienes, and essential fatty acids.

The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice.

H. Jaeschke, A. Ramachandran, J. Lemasters, 2022, Toxicology and applied pharmacology.

Mitochondria and xanthine oxidase both generate reactive oxygen species in isolated perfused rat liver after hypoxic injury.

H. Jaeschke, J. Mitchell, Hartmut Jaeschke, 1989, Biochemical and biophysical research communications.

Neutrophil-mediated tissue injury in alcoholic hepatitis.

H. Jaeschke, 2002, Alcohol.

4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes

H. Jaeschke, A. Ramachandran, B. Rumack, 2018, Human & experimental toxicology.

Role of PECAM-1 (CD31) in neutrophil transmigration in murine models of liver and peritoneal inflammation.

C. J. Dunn, H. Jaeschke, M. Fisher, 1998, The American journal of physiology.

BEYOND THE JOURNAL The enlarging role of matrix metalloproteinases in liver injury - beyond scar degradation

C. Trautwein, J. Boyer, T. Roskams, 2002 .

Regulation of Liver Regeneration by Hepatocyte O-GlcNAcylation in Mice

H. Jaeschke, U. Apte, J. Hanover, 2021, bioRxiv.

Platelet aggregation but not activation and degranulation during the acute post-ischemic reperfusion phase in livers with no underlying disease

P. Colarusso, H. Jaeschke, M. Heger, 2015, Journal of clinical and translational research.

Pathophysiology of hepatic ischemia-reperfusion injury: the role of complement activation.

H. Jaeschke, 1994, Gastroenterology.

Mechanisms of reperfusion injury after warm ischemia of the liver.

H. Jaeschke, H. Jaeschke, 1998, Journal of hepato-biliary-pancreatic surgery.

Inflammation and drug hepatotoxicity: Aggravation of injury or clean‐up mission?

H. Jaeschke, C. Cover, M. Bajt, 2005 .

Platanosides, a Potential Botanical Drug Combination, Decrease Liver Injury Caused by Acetaminophen Overdose in Mice.

H. Jaeschke, Nga T. Nguyen, M. Hamann, 2022, Journal of natural products.

Autophagy in macrophages regulates the inflammasome and protects against liver injury.

H. Jaeschke, W. Ding, 2016, Journal of hepatology.

Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease.

M. Maes, M. Vinken, H. Jaeschke, 2018, Biochimica et biophysica acta. Molecular basis of disease.

THE ROLE OF OXIDANT STRESS IN ACETAMINOPHE-INDUCED LIVER INJURY.

H. Jaeschke, A. Ramachandran, 2020, Current opinion in toxicology.

Use of isolated perfused organs in hypoxia and ischemia/reperfusion oxidant stress.

H. Jaeschke, J. Mitchell, 1990, Methods in enzymology.

Diquat hepatotoxicity in the Fischer-344 rat: the role of covalent binding to tissue proteins and lipids.

C. V. Smith, H. Jaeschke, J. Mitchell, 1989, Toxicology and applied pharmacology.

Choleresis and increased biliary efflux of glutathione induced by phenolic antioxidants in rats.

H. Jaeschke, A. Wendel, 1988, Toxicology.

Delayed Administration of N-Acetylcysteine Blunts Recovery After an Acetaminophen Overdose Unlike 4-Methylpyrazole

H. Jaeschke, A. Ramachandran, B. Rumack, 2021, Archives of Toxicology.

Increase in biliary permeability subsequent to intrahepatic cholestasis by estradiol valerate in rats.

H. Jaeschke, E. Trummer, H. Krell, 1987, Gastroenterology.

DAMPen danger signals: novel therapeutic strategies against postischemic inflammation.

H. Jaeschke, 2010, Critical care medicine.

How relevant are neutrophils for acetaminophen hepatotoxicity?

H. Jaeschke, 2006, Hepatology.

Mechanisms of Acetaminophen Hepatotoxicity: Do We Need JNK for Cell Death?

H. Jaeschke, 2016, Gastroenterology.

liver: attenuation by ischemic preconditioning neutrophils during ischemia-reperfusion injury in rat Generation of hypochlorite-modified proteins by

H. Jaeschke, A. Farhood, E. Malle, 2005 .

Bile acids trigger cholemic nephropathy in common bile‐duct–ligated mice

H. Denk, M. Pollheimer, C. Langner, 2013, Hepatology.

Troglitazone hepatotoxicity: are we getting closer to understanding idiosyncratic liver injury?

H. Jaeschke, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

THROMBOSIS AND HEMOSTASIS Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice

Mitchell R. McGill, H. Jaeschke, J. Luyendyk, 2015 .

Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose

H. Jaeschke, A. Ramachandran, B. Rumack, 2022, Archives of Toxicology.

Mitochondrial Damage and Biogenesis in Acetaminophen-induced Liver Injury.

H. Jaeschke, A. Ramachandran, Nga T. Nguyen, 2019, Liver research.

Herbal extracts as hepatoprotectants against acetaminophen hepatotoxicity.

Mitchell R. McGill, H. Jaeschke, A. Farhood, 2010, World journal of gastroenterology.

Critical role of CXC chemokines in endotoxemic liver injury in mice

H. Jaeschke, M. Bajt, 2004, Journal of leukocyte biology.

The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine livers

M. Manns, H. Jaeschke, A. Vogel, 2009, Hepatology.

Role of Pyroptosis in Acetaminophen-Induced Hepatotoxicity

H. Jaeschke, A. Ramachandran, David S. Umbaugh, 2022, Livers.

DIFFERENTIAL EFFECT OF 2-AMINOETHYL-ISOTHIOUREA, AN INHIBITOR OF THE INDUCIBLE NITRIC OXIDE SYNTHASE, ON MICROVASCULAR BLOOD FLOW AND ORGAN INJURY IN MODELS OF HEPATIC ISCHEMIA-REPERFUSION AND ENDOTOXEMIA

H. Jaeschke, J. A. Lawson, Ying Wang, 1998, Shock.

Sinusoidal endothelial cell and parenchymal cell injury during endotoxemia and hepatic ischemia-reperfusion: protection by the 21-aminosteroid tirilazad mesylate

H. Jaeschke, M. Fisher, R. Eversole, 1997 .

The 21-aminosteroid tirilazad mesylate protects against liver injury via membrane stabilization not inhibition of lipid peroxidation.

H. Jaeschke, W. Mathews, Y. Wang, 1996, The Journal of pharmacology and experimental therapeutics.

Neutrophil-induced lung damage after hepatic ischemia and endotoxemia.

H. Jaeschke, P. Liu, G. McGuire, 1996, Free radical biology & medicine.

The 21-aminosteroid tirilazad mesylate protects against endotoxin shock and acute liver failure in rats.

H. Jaeschke, M. Fisher, A. Farhood, 1994, The Journal of pharmacology and experimental therapeutics.

A possible role of plasma glutathione in glucose-mediated insulin secretion: in vitro and in vivo studies in rats

H. Jaeschke, A. Wendel, E. Verspohl, 1989, Diabetologia.

Preservation injury: mechanisms, prevention and consequences.

H. Jaeschke, H. Jaeschke, 1996, Journal of hepatology.

Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver.

H. Jaeschke, A. Farhood, H. Jaeschke, 1991, The American journal of physiology.

Role of neutrophils in acute inflammatory liver injury

H. Jaeschke, T. Hasegawa, 2006, Liver international : official journal of the International Association for the Study of the Liver.

Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo

C. Smith, H. Jaeschke, A. Farhood, 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Role of Neutrophils in the Pathogenesis of Acute Inflammatory Liver Injury

H. Jaeschke, S. Ramaiah, 2007, Toxicologic pathology.

Mechanisms of Liver Injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions.

H. Jaeschke, 2006, American journal of physiology. Gastrointestinal and liver physiology.

Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis

Victor R. Ambros, Hartmut Jaeschke, Isana Veksler-Lublinsky, 2014, Proceedings of the National Academy of Sciences.

Infrared and Raman Studies of Interactions between Salts and Amides or Esters

H. Jaeschke, J. Corset, M. Baron, 1977 .

Recovery of hepatocellular ATP and “pericentral apoptosis” after hemorrhage and resuscitation

H. Jaeschke, S. Kolb, M. Bauer, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products.

Mitchell R. McGill, H. Jaeschke, A. Ramachandran, 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity.

H. Jaeschke, M. Bajt, T. Knight, 2003, Toxicology letters.

The Effect of 4-Methylpyrazole on Oxidative Metabolism of Acetaminophen in Human Volunteers

H. Jaeschke, B. Rumack, R. Gerkin, 2019, Journal of Medical Toxicology.

Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice.

Mitchell R. McGill, H. Jaeschke, W. Ding, 2016, Journal of hepatology.

Hepatotoxins

H. Jaeschke, A. Ramachandran, 2019, Encyclopedia of Gastroenterology.

Acetaminophen Toxicity: Novel Insights Into Mechanisms and Future Perspectives.

H. Jaeschke, A. Ramachandran, 2018, Gene expression.

Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity.

Mitchell R. McGill, T. Asselah, H. Jaeschke, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure.

H. Jaeschke, B. Woolbright, 2017, Journal of hepatology.

Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients

H. Jaeschke, 2015 .

Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans.

Mitchell R. McGill, H. Jaeschke, A. Farhood, 2014, Toxicology and applied pharmacology.

Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity.

Mitchell R. McGill, H. Jaeschke, Kuo Du, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity.

Hartmut Jaeschke, Mitchell R. McGill, H. Jaeschke, 2012, Toxicology and applied pharmacology.

Mechanisms of neutrophil‐induced parenchymal cell injury

C. Smith, H. Jaeschke, C. Smith, 1997, Journal of leukocyte biology.

Mechanisms of hepatotoxicity.

G. Gores, H. Jaeschke, D. Pessayre, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Reduced oncotic necrosis in fas receptor‐deficient C57BL/6J‐lpr mice after bile duct ligation

H. Jaeschke, Jie Liu, A. Farhood, 2004, Hepatology.

Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress‐induced hepatocellular injury

H. Jaeschke, K. Ikejima, Sumio Watanabe, 2008, Hepatology.

Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation

Hartmut Jaeschke, Mitchell R. McGill, H. Jaeschke, 2018, Expert review of molecular diagnostics.

Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning.

Hartmut Jaeschke, H. Jaeschke, 2003, American journal of physiology. Gastrointestinal and liver physiology.

Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products.

Hartmut Jaeschke, Mitchell R. McGill, H. Jaeschke, 2011, Life sciences.

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N‐acetylcysteine

C. Zwingmann, H. Jaeschke, C. Saito, 2010, Hepatology.

Peroxynitrite Is a Critical Mediator of Acetaminophen Hepatotoxicity in Murine Livers: Protection by Glutathione

H. Jaeschke, Y. Ho, A. Farhood, 2002, Journal of Pharmacology and Experimental Therapeutics.

Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury.

H. Jaeschke, J. Lemasters, 2003, Gastroenterology.

Role of Reactive Oxygen Species in Hepatic Ischemia-Reperfusion Injury and Preconditioning

H. Jaeschke, 2003, Journal of investigative surgery : the official journal of the Academy of Surgical Research.

Protection against acetaminophen-induced liver injury by allopurinol is dependent on aldehyde oxidase-mediated liver preconditioning.

Mitchell R. McGill, H. Jaeschke, C. Williams, 2014, Toxicology and applied pharmacology.

Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species.

H. Jaeschke, B. Woolbright, 2012, Transplantation reviews.

Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine.

H. Jaeschke, J. Lemasters, M. Bajt, 2004, Toxicological sciences : an official journal of the Society of Toxicology.

Oxidative Stress and Acute Hepatic Injury.

H. Jaeschke, A. Ramachandran, 2018, Current opinion in toxicology.

Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts

Hartmut Jaeschke, H. Jaeschke, 2011, Journal of gastroenterology and hepatology.

Animal models of drug-induced liver injury.

Mitchell R. McGill, H. Jaeschke, 2019, Biochimica et Biophysica Acta - Molecular Basis of Disease.

Critical review of resveratrol in xenobiotic-induced hepatotoxicity.

Mitchell R. McGill, H. Jaeschke, Kuo Du, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Drug-induced lipid peroxidation in mice--II. Protection against paracetamol-induced liver necrosis by intravenous liposomally entrapped glutathione.

H. Jaeschke, A. Wendel, M. Gloger, 1982, Biochemical pharmacology.

Mitochondrial Membrane Potential Drives Early Change in Mitochondrial Morphology After Acetaminophen Exposure.

H. Jaeschke, A. Ramachandran, Nga T. Nguyen, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Oxidative Stress in Acute Liver Failure

Mitchell R. McGill, H. Jaeschke, 2015 .

Kupffer cell activation after no-flow ischemia versus hemorrhagic shock.

H. Jaeschke, A. Farhood, 2002, Free radical biology & medicine.

Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen.

H. Jaeschke, E. Kuffner, B. Howell, 2020, Regulatory toxicology and pharmacology : RTP.

No increase of biliary permeability in ethinylestradiol-treated rats

H. Jaeschke, H. Krell, E. Pfaff, 1983 .

Role of lipid peroxidation as a mechanism of liver injury after acetaminophen overdose in mice.

H. Jaeschke, A. Farhood, M. Fariss, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Experimental models of hepatotoxicity related to acute liver failure.

M. Maes, M. Vinken, H. Jaeschke, 2016, Toxicology and applied pharmacology.

Serum mitochondrial biomarkers and damage‐associated molecular patterns are higher in acetaminophen overdose patients with poor outcome

William M. Lee, Mitchell R. McGill, H. Jaeschke, 2014, Hepatology.

Mechanisms of immune-mediated liver injury.

D. Adams, H. Jaeschke, S. Ramaiah, 2010, Toxicological Sciences.

Superoxide generation by neutrophils and Kupffer cells during in vivo reperfusion after hepatic ischemia in rats

H. Jaeschke, J. Spitzer, Z. Spolarics, 1992, Journal of leukocyte biology.

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

Mitchell R. McGill, H. Jaeschke, 2013, Pharmaceutical Research.

Functional inactivation of neutrophils with a Mac‐1 (CD11b/CD18) monoclonal antibody protects against ischemia‐reperfusion injury in rat liver

C. Smith, H. Jaeschke, J. Spitzer, 1993, Hepatology.

Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct–ligated mice

H. Jaeschke, A. Farhood, M. Bajt, 2003, Hepatology.

Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential

H. Jaeschke, A. Ramachandran, Kuo Du, 2016, Redox biology.

Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis

Mitchell R. McGill, H. Jaeschke, B. Bhushan, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Paradoxical Role of Yes‐Associated Protein (YAP) in Liver Injury and Regeneration following Acetaminophen Overdose

Mitchell R. McGill, H. Jaeschke, B. Bhushan, 2016 .

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications.

Hartmut Jaeschke, Mitchell R. McGill, H. Jaeschke, 2013, Toxicology and applied pharmacology.

Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity

Mitchell R. McGill, M. Maes, M. Vinken, 2017, Archives of Toxicology.

Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients

Mitchell R. McGill, H. Jaeschke, 2014, Expert opinion on drug metabolism & toxicology.

Functional importance of ICAM-1 in the mechanism of neutrophil-induced liver injury in bile duct-ligated mice.

H. Jaeschke, Jie Liu, A. Farhood, 2004, American journal of physiology. Gastrointestinal and liver physiology.

Mechanisms of Acetaminophen-Induced Liver Injury

H. Jaeschke, B. Woolbright, 2017 .

Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells

Mitchell R. McGill, H. Jaeschke, R. Winefield, 2015, Xenobiotica; the fate of foreign compounds in biological systems.

Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis?

H. Jaeschke, A. Farhood, M. Bajt, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Mechanisms of Oxidant Stress-Induced Acute Tissue Injury

H. Jaeschke, 1995, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3)-Mixed Lineage Kinase Domain-Like Protein (MLKL)-Mediated Necroptosis Contributes to Ischemia-Reperfusion Injury of Steatotic Livers.

H. Jaeschke, Tiangang Li, W. Ding, 2019, The American journal of pathology.

Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury

H. Jaeschke, A. Ramachandran, C. Baines, 2011, Free radical research.

Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives

H. Jaeschke, A. Ramachandran, J. Akakpo, 2018, Journal of clinical and translational research.

Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology

H. Jaeschke, A. Ramachandran, 2017, Journal of clinical and translational research.

Chapter 6 – Acetaminophen

H. Jaeschke, A. Ramachandran, 2017 .

Acetaminophen Hepatotoxicity

H. Jaeschke, A. Ramachandran, 2019, Seminars in Liver Disease.

Reactive oxygen species in the normal and acutely injured liver.

H. Jaeschke, A. Ramachandran, 2011, Journal of hepatology.

BEYOND THE JOURNAL

C. Trautwein, J. Boyer, T. Roskams, 2003 .

Differential activation pattern of redox-sensitive transcription factors and stress-inducible dilator systems heme oxygenase-1 and inducible nitric oxide synthase in hemorrhagic and endotoxic shock

H. Jaeschke, M. Bauer, H. Rensing, 2001, Critical care medicine.

p53-Independent Induction of p21 Fails to Control Regeneration and Hepatocarcinogenesis in a Murine Liver Injury Model

Amar Deep Sharma, R. Geffers, H. Jaeschke, 2021, Cellular and molecular gastroenterology and hepatology.

Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice.

Hartmut Jaeschke, H. Jaeschke, R. Jenkins, 2013, Toxicology and applied pharmacology.

The role of apoptosis in acetaminophen hepatotoxicity.

H. Jaeschke, A. Ramachandran, A. Farhood, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J.

H. Jaeschke, M. Bourdi, B. Woolbright, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Fas receptor-deficient lpr mice are protected against acetaminophen hepatotoxicity due to higher glutathione synthesis and enhanced detoxification of oxidant stress.

Mitchell R. McGill, H. Jaeschke, A. Farhood, 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Extracellular vesicles: Roles and applications in drug-induced liver injury.

H. Jaeschke, David S. Umbaugh, 2021, Advances in clinical chemistry.

Activation of autophagy protects against acetaminophen‐induced hepatotoxicity

H. Jaeschke, W. Ding, Nikki Boggess, 2012, Hepatology.

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

Mitchell R. McGill, H. Jaeschke, 2013, Pharmaceutical Research.

HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity

Hartmut Jaeschke, Mitchell R. McGill, H. Jaeschke, 2011, Hepatology.

The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress

G. Raghu, P. Campochiaro, P. Calverley, 2020, Current neuropharmacology.

Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.

Mitchell R. McGill, H. Jaeschke, K. Dorko, 2014, Toxicology and applied pharmacology.

Adam S. Hayward, C. Meyer, S. Dooley, 2013, Archives of Toxicology.

Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans

Mitchell R. McGill, H. Jaeschke, Feng Li, 2014, Archives of Toxicology.

Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen‐induced hepatocyte necrosis in mice

Mitchell R. McGill, H. Jaeschke, A. Ramachandran, 2013, Hepatology.

Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury.

H. Jaeschke, A. Farhood, C. Williams, 2010, Toxicology and applied pharmacology.

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity.

H. Jaeschke, J. Lemasters, C. Saito, 2010, Toxicology and applied pharmacology.

Mitochondrial permeability transition in acetaminophen‐induced necrosis and apoptosis of cultured mouse hepatocytes

H. Jaeschke, J. Lemasters, Jae‐Sung Kim, 2004, Hepatology.

Inhibition of Fas receptor (CD95)-induced hepatic caspase activation and apoptosis by acetaminophen in mice.

H. Jaeschke, M. Fisher, A. Farhood, 1999, Toxicology and applied pharmacology.

Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation.

H. Jaeschke, Ji-Young Hong, A. Farhood, 2009, American journal of physiology. Gastrointestinal and liver physiology.

Intracellular signaling mechanisms of acetaminophen-induced liver cell death.

Hartmut Jaeschke, H. Jaeschke, Mary Lynn Bajt, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Prevention of Kupffer cell-induced oxidant injury in rat liver by atrial natriuretic peptide.

A. Vollmar, H. Jaeschke, A. Gerbes, 1999, American journal of physiology. Gastrointestinal and liver physiology.

Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients.

William M. Lee, Mitchell R. McGill, H. Jaeschke, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Mice deficient in pyruvate dehydrogenase kinase 4 are protected against acetaminophen-induced hepatotoxicity.

H. Jaeschke, A. Ramachandran, B. Woolbright, 2019, Toxicology and applied pharmacology.

Regulation of apoptotic signaling pathways in hepatocytes in vivo

H. Jaeschke, M. Bajt, Mary Lynn Bajt, 2003, Hepatology.

Lysosomal iron mobilization and induction of the mitochondrial permeability transition in acetaminophen-induced toxicity to mouse hepatocytes.

H. Jaeschke, J. Lemasters, Jae‐Sung Kim, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Mitochondrial Protein Adduct and Superoxide Generation are Prerequisites for Early Activation of c-Jun N-terminal Kinase within the Cytosol after an Acetaminophen Overdose in Mice.

H. Jaeschke, A. Ramachandran, Nga T. Nguyen, 2020, Toxicology letters.

Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes.

Mitchell R. McGill, H. Jaeschke, K. Dorko, 2015, Toxicology and applied pharmacology.

Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms

Glen E. P. Ropella, C. Anthony Hunt, Andrew K. Smith, 2019, bioRxiv.

Oncotic necrosis and caspase-dependent apoptosis during galactosamine-induced liver injury in rats.

H. Jaeschke, A. Farhood, J. Gujral, 2003, Toxicology and applied pharmacology.

Activation of the adenosine A2B receptor even beyond the therapeutic window of N-acetylcysteine accelerates liver recovery after an Acetaminophen overdose.

H. Jaeschke, A. Ramachandran, Giselle Sánchez-Guerrero, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls

H. Jaeschke, A. Ramachandran, Nga T. Nguyen, 2021, Acta pharmaceutica Sinica. B.

Letter to the Editor: Does c‐Jun N‐Terminal Kinase Regulate Acetaminophen Hepatotoxicity by Modulating Nuclear Factor Erythroid 2–Related Factor 2–Dependent Genes or Mitochondrial Oxidant Stress?

H. Jaeschke, A. Ramachandran, 2020 .

Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity

H. Jaeschke, A. Ramachandran, W. Ding, 2018, Archives of Toxicology.

Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity

H. Jaeschke, A. Farhood, Kuo Du, 2016, Archives of Toxicology.

Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.

Mitchell R. McGill, H. Jaeschke, C. Williams, 2014, Toxicology and applied pharmacology.

Differences in Early Acetaminophen Hepatotoxicity between Obese ob/ob and db/db Mice

Mitchell R. McGill, H. Jaeschke, B. Fromenty, 2012, Journal of Pharmacology and Experimental Therapeutics.

Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.

H. Jaeschke, A. Ramachandran, A. Farhood, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity.

H. Jaeschke, A. Ramachandran, S. Weinman, 2011, Toxicology and applied pharmacology.

Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury.

H. Jaeschke, J. Lemasters, C. Cover, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Peroxynitrite-Induced Mitochondrial and Endonuclease-Mediated Nuclear DNA Damage in Acetaminophen Hepatotoxicity

H. Jaeschke, D. Pessayre, J. Lemasters, 2005, Journal of Pharmacology and Experimental Therapeutics.

Activation of caspase 3 (CPP32)-like proteases is essential for TNF-alpha-induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model.

H. Jaeschke, D. Jones, M. Fisher, 1998, Journal of immunology.

Endotoxin Shock Model Neutrophil-Mediated Necrosis in a Murine Parenchymal Cell Apoptosis and-Induced Hepatic α Is Essential for TNF-Activation of Caspase 3 ( CPP 32 )-Like Proteases

H. Jaeschke, M. Fisher, A. Farhood, 1998 .

III. Leukocyte adhesion and transmigration in the liver vasculature.

C. Smith, H. Jaeschke, C. Smith, 1997, American journal of physiology. Gastrointestinal and liver physiology.

Chapter 3 – Mechanisms of Liver Cell Destruction

H. Jaeschke, 2006 .

Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice.

H. Jaeschke, J. Luyendyk, N. Mackman, 2011, Toxicology and applied pharmacology.

Disposition and hepatoprotection by phosphatidyl choline liposomes in mouse liver.

H. Jaeschke, A. Wendel, C. Werner, 1987, Chemico-biological interactions.

Gene array analysis of the hepatic response to endotoxin in glutathione peroxidase-deficient mice.

H. Jaeschke, Jie Liu, Chengxiu Li, 2003, Toxicology letters.

Biomarkers of Mitochondrial Damage in the Liver

Mitchell R. McGill, H. Jaeschke, 2015 .

Mechanisms of inflammatory liver injury: adhesion molecules and cytotoxicity of neutrophils.

C. Smith, H. Jaeschke, M. Clemens, 1996, Toxicology and applied pharmacology.

Mechanisms of Acetaminophen Hepatotoxicity: Cell Death Signaling Mechanisms in Hepatocytes

H. Jaeschke, A. Ramachandran, M. Bajt, 2018 .

The therapeutic potential of glutathione in hepatic ischemia-reperfusion injury.

H. Jaeschke, 1993, Transplantation.

Apoptosis and necrosis in liver disease

Hartmut Jaeschke, H. Jaeschke, M. Bajt, 2004, Liver international : official journal of the International Association for the Study of the Liver.

Role of innate and adaptive immunity during drug-induced liver injury

H. Jaeschke, C. Williams, 2012 .

Reperfusion injury after warm ischemia or cold storage of the liver: role of apoptotic cell death.

H. Jaeschke, 2002, Transplantation proceedings.

Oxidant Stress, Antioxidant Defense, and Liver Injury

Mitchell R. McGill, H. Jaeschke, 2013 .

Generation of hypochlorite-modified proteins by neutrophils during ischemia-reperfusion injury in rat liver: attenuation by ischemic preconditioning.

H. Jaeschke, A. Farhood, E. Malle, 2005, American journal of physiology. Gastrointestinal and liver physiology.

MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury

Mitchell R. McGill, H. Jaeschke, 2015, Journal of clinical medicine.

A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis.

K. Zatloukal, H. Denk, H. Jaeschke, 2007, The American journal of pathology.

Biomarkers distinguish apoptotic and necrotic cell death during hepatic ischemia/reperfusion injury in mice

H. Jaeschke, R. Jenkins, D. Antoine, 2014, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

Superoxide generation by Kupffer cells and priming of neutrophils during reperfusion after hepatic ischemia.

H. Jaeschke, J. Spitzer, Z. Spolarics, 1991, Free radical research communications.

Progress in Understanding the Pathogenesis of Nonalcoholic Fatty Liver Disease

H. Jaeschke, D. Moradpour, K. Mullen, 2004 .

Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice

Mitchell R. McGill, H. Jaeschke, B. Bhushan, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

Spatial Reconstruction of the Early Hepatic Transcriptomic Landscape after an Acetaminophen Overdose using Single-cell RNA Sequencing.

H. Jaeschke, A. Ramachandran, David S. Umbaugh, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Aldehyde dehydrogenase-2 activation decreases acetaminophen hepatotoxicity by prevention of mitochondrial depolarization.

H. Jaeschke, Nga T. Nguyen, J. Lemasters, 2020, Toxicology and applied pharmacology.

The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes.

H. Jaeschke, A. Ramachandran, J. Lemasters, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Mechanisms of Inflammatory Liver Injury and Drug-Induced Hepatotoxicity

H. Jaeschke, B. Woolbright, 2018, Current Pharmacology Reports.

Mechanisms of Inflammatory Liver Injury and Drug-Induced Hepatotoxicity

H. Jaeschke, B. Woolbright, 2018, Current Pharmacology Reports.

Acetaminophen-induced apoptosis: Facts versus fiction

H. Jaeschke, A. Ramachandran, 2020, Journal of clinical and translational research.

Emerging and established modes of cell death during acetaminophen-induced liver injury

H. Jaeschke, A. Ramachandran, W. Ding, 2019, Archives of Toxicology.

Is Keratin-18 only a Marker of Cell Death in Acute-On-Chronic Liver Failure?

H. Jaeschke, B. Woolbright, 2018, Journal of laboratory and precision medicine.

Biomarkers of Mitochondrial Injury After Acetaminophen Overdose

H. Jaeschke, B. Woolbright, 2018 .

Acetaminophen-induced Liver Injury: from Animal Models to Humans

Hartmut Jaeschke, Mitchell R. McGill, H. Jaeschke, 2014, Journal of clinical and translational hepatology.

Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice.

Hartmut Jaeschke, H. Jaeschke, M. Trauner, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity

Mitchell R. McGill, H. Jaeschke, Kuo Du, 2015, Expert opinion on drug metabolism & toxicology.

Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis

H. Jaeschke, Tiangang Li, B. Bruinsma, 2018, Journal of clinical and translational research.

Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.

H. Jaeschke, A. Ramachandran, P. Krishnamurthy, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation.

Mitchell R. McGill, M. Vinken, H. Jaeschke, 2013, Toxicology and applied pharmacology.

Immune Mechanisms in Drug-Induced Liver Injury

H. Jaeschke, D. Naisbitt, 2018 .

Novel insight into mechanisms of cholestatic liver injury.

Hartmut Jaeschke, H. Jaeschke, B. Woolbright, 2012, World journal of gastroenterology.

Transcriptional activation of heme oxygenase-1 and its functional significance in acetaminophen-induced hepatitis and hepatocellular injury in the rat.

H. Jaeschke, B. Vollmar, B Vollmar, 2000, Journal of hepatology.

15th International Symposium on Cells of the Hepatic Sinusoid, 2010

D. Brenner, H. Jaeschke, H. Tsukamoto, 2011, Liver international : official journal of the International Association for the Study of the Liver.

Comments on “Glycogen Synthase Kinase-3 Mediates Acetaminophen-Induced Apoptosis in Human Hepatoma Cells”

H. Jaeschke, 2005, Journal of Pharmacology and Experimental Therapeutics.

Mitochondrial Bax Translocation Accelerates DNA Fragmentation and Cell Necrosis in a Murine Model of Acetaminophen Hepatotoxicity

H. Jaeschke, A. Farhood, J. Lemasters, 2008, Journal of Pharmacology and Experimental Therapeutics.

Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol.

H. Jaeschke, Hartmut Jaeschke, 1990, The Journal of pharmacology and experimental therapeutics.

Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity.

H. Jaeschke, Jie Liu, A. Farhood, 2006, Toxicology and applied pharmacology.

Microchimerism in liver allografts: the swing of the pendulum

C. Trautwein, J. Boyer, T. Roskams, 2004 .

Oxidative stress and signaling in the liver

Mitchell R. McGill, H. Jaeschke, Yuchao Xie, 2015 .

Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis

Mitchell R. McGill, H. Jaeschke, R. Jenkins, 2017, Liver international : official journal of the International Association for the Study of the Liver.

Mechanisms and in vitro models of drug-induced cholestasis

M. Vinken, H. Jaeschke, P. Annaert, 2019, Archives of Toxicology.

Xenobiotic and Endobiotic Mediated Interactions Between the Cytochrome P450 System and the Inflammatory Response in the Liver.

H. Jaeschke, B. Woolbright, 2015, Advances in pharmacology.

Glutathione peroxidase–deficient mice are more susceptible to neutrophil‐mediated hepatic parenchymal cell injury during endotoxemia: importance of an intracellular oxidant stress

H. Jaeschke, Y. Ho, M. Fisher, 1999, Hepatology.

Lipid peroxidation as molecular mechanism of liver cell injury during reperfusion after ischemia.

H. Jaeschke, M. Fisher, W. Mathews, 1994, Free radical biology & medicine.

Priming of phagocytes for reactive oxygen production during hepatic ischemia-reperfusion potentiates the susceptibility for endotoxin-induced liver injury.

H. Jaeschke, M. Fisher, S. Vonderfecht, 1993, Circulatory shock.

Oxidant Stress and Drug-Induced Hepatotoxicity

Mitchell R. McGill, H. Jaeschke, A. Ramachandran, 2014 .

Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury.

Imran Shah, Brigitte Landesmann, Vera Rogiers, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

4-methylpyrazole protects against acetaminophen-induced acute kidney injury.

H. Jaeschke, A. Ramachandran, B. Rumack, 2020, Toxicology and applied pharmacology.

Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose

H. Jaeschke, A. Ramachandran, B. Rumack, 2022, Archives of Toxicology.

The Relationship Between Circulating Acetaminophen-Protein Adduct Concentrations and Alanine Aminotransferase Activities in Patients With and Without Acetaminophen Overdose and Toxicity

Aaron B. Skolnik, H. Jaeschke, D. E. Brooks, 2019, Journal of Medical Toxicology.

Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase.

H. Jaeschke, A. Ramachandran, B. Rumack, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Acetaminophen‐induced hepatic neutrophil accumulation and inflammatory liver injury in CD18‐deficient mice

H. Jaeschke, A. Farhood, C. Williams, 2010, Liver international : official journal of the International Association for the Study of the Liver.

Role of caspases in acetaminophen-induced liver injury.

H. Jaeschke, C. Cover, M. Bajt, 2006, Life sciences.

Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity

T. Luedde, J. Rahnenführer, A. Canbay, 2022, Journal of hepatology.

Cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity.

Mitchell R. McGill, H. Jaeschke, 2015, Toxicology letters.

PGAM5: a new player in immune-mediated liver injury

H. Jaeschke, A. Ramachandran, 2016, Gut.

Mechanistic Biomarkers in Liver Diseases

Hartmut Jaeschke, Mitchell R. McGill, H. Jaeschke, 2017 .

Connexin hemichannel inhibition reduces acetaminophen-induced liver injury in mice.

M. Maes, M. Vinken, H. Jaeschke, 2017, Toxicology letters.

Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways

Mitchell R. McGill, H. Jaeschke, R. Panettieri, 2019, Xenobiotica; the fate of foreign compounds in biological systems.

Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver.

Mitchell R. McGill, H. Jaeschke, J. Lemasters, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Caspase inhibitors for the treatment of liver disease: friend or foe?

H. Jaeschke, W. Ding, B. Woolbright, 2017, Expert review of gastroenterology & hepatology.

Caspase Inhibition Prevents Tumor Necrosis Factor-α-Induced Apoptosis and Promotes Necrotic Cell Death in Mouse Hepatocytes in Vivo and in Vitro.

Mitchell R. McGill, H. Jaeschke, W. Ding, 2016, The American journal of pathology.

Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange

Glen E. P. Ropella, Hartmut Jaeschke, Mitchell R. McGill, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Late Protective Effect of Netrin-1 in the Murine Acetaminophen Hepatotoxicity Model.

H. Jaeschke, A. Ramachandran, B. Woolbright, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

A Comprehensive Weight of Evidence Assessment of Published Acetaminophen Genotoxicity Data: Implications for its Carcinogenic Hazard Potential.

H. Jaeschke, D. Kirkland, M. Kovochich, 2021, Regulatory toxicology and pharmacology : RTP.

Mitochondrial protein thiol modifications in acetaminophen hepatotoxicity: effect on HMG-CoA synthase.

H. Jaeschke, S. Bailey, M. Bajt, 2008, Toxicology letters.

Differential induction of mRNA for ICAM-1 and selectins in hepatocytes, Kupffer cells and endothelial cells during endotoxemia.

H. Jaeschke, A. Manning, N. Essani, 1995, Biochemical and biophysical research communications.

The impact of sterile inflammation in acute liver injury

H. Jaeschke, B. Woolbright, 2017, Journal of clinical and translational research.

Acetaminophen Toxicity in Mice Lacking NADPH Oxidase Activity: Role of Peroxynitrite Formation and Mitochondrial Oxidant Stress

H. Jaeschke, L. James, J. Hinson, 2003, Free radical research.

Beneficial effects of extracellular glutathione against endotoxin-induced liver injury during ischemia and reperfusion.

C. Smith, H. Jaeschke, Peitan Liu, 1994, Circulatory shock.

Novel strategies for the treatment of acetaminophen hepatotoxicity

H. Jaeschke, A. Ramachandran, J. Akakpo, 2020, Expert opinion on drug metabolism & toxicology.

Drug-induced intrahepatic cholestasis: characterization of different pathomechanisms

H. Jaeschke, H. Krell, J. Metz, 2004, Archives of Toxicology.

Regulation of canalicular bile formation by alpha-adrenergic action and by external ATP in the isolated perfused rat liver.

H. Jaeschke, H. Krell, E. Pfaff, 1985, Biochemical and biophysical research communications.

Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice

H. Jaeschke, A. Ramachandran, W. Ding, 2021, Archives of Toxicology.

Emerging novel therapies against paracetamol (acetaminophen) hepatotoxicity

H. Jaeschke, 2019, EBioMedicine.

Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans

Mitchell R. McGill, H. Jaeschke, A. Farhood, 2014, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations.

Mitchell R. McGill, Michael D Hambuchen, H. Jaeschke, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Experimental Models of Hepatotoxicity for the Testing of Natural Products

A. Ramachandran, H. Jaeschke, H. Jaeschke, 2013 .

Parkin and Mitofusins Reciprocally Regulate Mitophagy and Mitochondrial Spheroid Formation*

D. Stolz, H. Jaeschke, Xiao-Ming Yin, 2012, The Journal of Biological Chemistry.

Ferroptosis and Acetaminophen Hepatotoxicity - Are We Going Down Another Rabbit Hole?

H. Jaeschke, A. Ramachandran, Ola Adelusi, 2021, Gene expression.

Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives

H. Jaeschke, A. Ramachandran, J. Akakpo, 2018, Journal of clinical and translational research.

[Pathogenetic mechanisms of acute liver failure].

H. Jaeschke, 1994, Zentralblatt fur Chirurgie.

Neutrophil depletion protects against murine acetaminophen hepatotoxicity: Another perspective

H. Jaeschke, Jie Liu, 2007, Hepatology.

NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia.

H. Jaeschke, A. Farhood, J. Hinson, 2004, American journal of physiology. Gastrointestinal and liver physiology.

Measuring Apoptosis and Necrosis in Cholestatic Liver Injury.

H. Jaeschke, B. Woolbright, 2019, Methods in molecular biology.

Scavenging Peroxynitrite with Glutathione Promotes Regeneration and Enhances Survival during Acetaminophen-Induced Liver Injury in Mice

H. Jaeschke, A. Farhood, M. Bajt, 2003, Journal of Pharmacology and Experimental Therapeutics.

Increased P‐selectin gene expression in the liver vasculature and its role in the pathophysiology of neutrophil‐induced liver injury in murine endotoxin shock

H. Jaeschke, N. Essani, M. Fisher, 1998, Journal of leukocyte biology.

Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver☆

Hartmut Jaeschke, H. Jaeschke, W. Ding, 2013, Redox biology.

Acetaminophen knocks on death's door and receptor interacting protein 1 kinase answers

G. Gores, H. Jaeschke, M. E. Guicciardi, 2015, Hepatology.

Enhanced sinusoidal glutathione efflux during endotoxin-induced oxidant stress in vivo.

H. Jaeschke, H. Jaeschke, 1992, The American journal of physiology.

Is anti-P-selectin therapy effective in hepatic ischemia-reperfusion injury because it inhibits neutrophil recruitment?

H. Jaeschke, 1999, Shock.

Dual roles of p62/SQSTM1 in the injury and recovery phases of acetaminophen-induced liver injury in mice

K. Zatloukal, T. Rülicke, H. Jaeschke, 2021, Acta pharmaceutica Sinica. B.

Biomarkers of mitotoxicity after acute liver injury: Further insights into the interpretation of glutamate dehydrogenase

Mitchell R. McGill, H. Jaeschke, 2021, Journal of clinical and translational research.

Sterile inflammation in acute liver injury: myth or mystery?

H. Jaeschke, B. Woolbright, 2015, Expert review of gastroenterology & hepatology.

Cell Death and Prognosis of Mortality in Alcoholic Hepatitis Patients Using Plasma Keratin-18.

H. Jaeschke, S. Weinman, B. Woolbright, 2017, Gene expression.

The role of osteopontin and tumor necrosis factor alpha receptor-1 in xenobiotic-induced cholangitis and biliary fibrosis in mice

H. Denk, H. Jaeschke, M. Trauner, 2010, Laboratory Investigation.

Anti‐selectin therapy against hepatic ischemia‐reperfusion injury

H. Jaeschke, 2003 .

Oxidant Stress and Acetaminophen Hepatotoxicity: Mechanism-Based Drug Development.

H. Jaeschke, A. Ramachandran, 2021, Antioxidants & redox signaling.

Role of heme oxygenase 1 in TNF/TNF receptor-mediated apoptosis after hepatic ischemia/reperfusion in rats. Shock 39: 380-388, 2013.

H. Jaeschke, B. Woolbright, 2013, Shock.

Heme oxygenase‐1 and platelets in hepatic ischemia reperfusion injury

H. Jaeschke, B. Woolbright, 2013, Journal of gastroenterology and hepatology.

No evidence for caspase‐dependent apoptosis in acetaminophen hepatotoxicity

H. Jaeschke, A. Farhood, C. Williams, 2011, Hepatology.

Microcystin‐LR induced liver injury in mice and in primary human hepatocytes is caused by oncotic necrosis

H. Jaeschke, S. Kumer, B. Woolbright, 2017, Toxicon : official journal of the International Society on Toxinology.

Acetaminophen-induced inhibition of Fas receptor-mediated liver cell apoptosis: mitochondrial dysfunction versus glutathione depletion.

H. Jaeschke, T. Knight, 2002, Toxicology and applied pharmacology.

Role of extracellular vesicles in release of protein adducts after acetaminophen-induced liver injury in mice and humans.

H. Jaeschke, A. Ramachandran, S. Curry, 2019, Toxicology letters.

Hearing, reactive metabolite formation, and oxidative stress in cochleae after a single acute overdose of acetaminophen: an in vivo study

Mitchell R. McGill, H. Jaeschke, D. Durham, 2016, Toxicology mechanisms and methods.

Redox considerations in hepatic injury and inflammation.

H. Jaeschke, 2002, Antioxidants & redox signaling.

Mitochondria in Acetaminophen-Induced Liver Injury and Recovery: A Concise Review

H. Jaeschke, A. Ramachandran, 2023, Livers.

Dose-dependent pleiotropic role of neutrophils during acetaminophen-induced liver injury in male and female mice

H. Jaeschke, A. Ramachandran, David S. Umbaugh, 2023, Archives of Toxicology.

Recovered Hepatocytes Promote Macrophage Apoptosis through CXCR4 after Acetaminophen-Induced Liver Injury in Mice.

H. Jaeschke, A. Ramachandran, David S. Umbaugh, 2022, Toxicological Sciences.

Interleukin-4 and acetaminophen hepatotoxicity: a story of conflicting results and conclusions

H. Jaeschke, 2014, Inflammation Research.

Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice

H. Jaeschke, A. Ramachandran, S. Weinman, 2015, Archives of Toxicology.

Autophagy and acetaminophen hepatotoxicity: how useful are Atg7-deficient mice?

H. Jaeschke, W. Ding, 2012, Journal of Gastroenterology.

Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation.

Mitchell R. McGill, H. Jaeschke, A. Ramachandran, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Hepatocyte Specific Deletion of Yes-Associated Protein (YAP) Improves Recovery from Acetaminophen-Induced Acute Liver Injury.

H. Jaeschke, B. Bhushan, U. Apte, 2021, Toxicological Sciences.

Hepatic Neutrophil Infiltration in the Pathogenesis of Alcohol-Induced Liver Injury

H. Jaeschke, S. Ramaiah, 2007, Toxicology mechanisms and methods.

Quantitative estimation of transcellular and paracellular pathways of biliary sucrose in isolated perfused rat liver.

H. Jaeschke, H. Krell, E. Pfaff, 1987, Biochemical Journal.

Acetaminophen Hepatotoxicity: Not as Simple as One Might Think! Introductory Comments on the Special Issue—Recent Advances in Acetaminophen Hepatotoxicity

H. Jaeschke, 2022, Livers.

175 Apoptosis and oncotic necrosis during acute liver injury after bile duct ligation in mice

H. Jaeschke, A. Farhood, J. Gujral, 2003 .

The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury

Mitchell R. McGill, H. Jaeschke, W. Ding, 2015, Xenobiotica; the fate of foreign compounds in biological systems.

Serum glutamate dehydrogenase--biomarker for liver cell death or mitochondrial dysfunction?

Mitchell R. McGill, H. Jaeschke, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Oxidative Stress and Inflammation in the Liver

H. Jaeschke, J. Lemasters, 2020 .

The Relationship Between Circulating Acetaminophen-Protein Adduct Concentrations and Alanine Aminotransferase Activities in Patients With and Without Acetaminophen Overdose and Toxicity

H. Jaeschke, R. Gerkin, S. Curry, 2019, Journal of Medical Toxicology.

Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity.

Mitchell R. McGill, H. Jaeschke, K. Dorko, 2015, Journal of clinical and translational research.

Caveats of using acetaminophen hepatotoxicity models for natural product testing.

Mitchell R. McGill, H. Jaeschke, C. Williams, 2012, Toxicology letters.

Acetaminophen-induced injury and acute liver failure as a clinically relevant model Acetaminophen- (APAP) induced acute liver failure (ALF) is a major cause of morbidity and mortality in the US (1)

H. Jaeschke, B. Woolbright, 2016 .

Prevention of Kupffer cell-induced oxidant injury in rat liver by atrial natriuretic peptide

A. Vollmar, H. Jaeschke, A. Gerbes, 1999 .

Chlorotyrosine protein adducts are reliable biomarkers of neutrophil-induced cytotoxicity in vivo

H. Jaeschke, J. Hinson, J. Gujral, 2004, Comparative hepatology.

Protection against acetaminophen-induced liver injury with MG53: muscle-liver axis and necroptosis.

H. Jaeschke, David S. Umbaugh, 2022, Journal of hepatology.

Response to the opinion letter entitled Role of Ferroptosis in Acetaminophen Hepatotoxicity by Yamada et al.

H. Jaeschke, A. Ramachandran, 2020, Archives of Toxicology.

An Expert Roundtable Discussion on Mitochondrial Toxicity

M. Vinken, H. Jaeschke, P. Hewitt, 2019 .

Peroxynitrite formation and sinusoidal endothelial cell injury during acetaminophen-induced hepatotoxicity in mice

H. Jaeschke, T. Knight, 2004, Comparative hepatology.

Pleiotropic Roles of Platelets and Neutrophils in Cell Death and Recovery During Acetaminophen Hepatotoxicity

H. Jaeschke, A. Ramachandran, 2020, Hepatology.

Liuweiwuling tablets protect against acetaminophen hepatotoxicity: What is the protective mechanism?

H. Jaeschke, Kuo Du, 2016, World journal of gastroenterology.

Putative Effects of an Orally Administered Anti-TLR4 Antibody on Gut Microbiota and Acetaminophen Hepatotoxicity in Mice

H. Jaeschke, A. Ramachandran, 2022, Microbiology spectrum.

Neurologic cues modulate immune‐mediated liver injury and regeneration

H. Jaeschke, B. Woolbright, 2016, Hepatology.

Therapeutic strategies against ischemia-reperfusion injury: stem cell therapy and beyond.

H. Jaeschke, 2012, Critical care medicine.

Chemokines and liver inflammation: The battle between pro‐ and anti‐inflammatory mediators

H. Jaeschke, 1997, Hepatology.

Commentary on 'Isolated cells in the study of the molecular mechanisms of reperfusion injury' by H. de Groot.

H. Jaeschke, 1992, Toxicology letters.

Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses.

Mitchell R. McGill, H. Jaeschke, Kuo Du, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Acetaminophen hepatotoxicity and sterile inflammation: The mechanism of protection of Chlorogenic acid.

H. Jaeschke, 2016, Chemico-biological interactions.

export pump (Bsep/Abcb11) correlate with severity of cholestatic diseases Levels of plasma membrane expression in progressive and benign mutations of the bile salt

C. Trautwein, F. Lammert, H. Denk, 2007 .

Comments on Caspase-Mediated Anti-Apoptotic Effect of Ginsenoside Rg5, a Main Rare Ginsenoside, on Acetaminophen-Induced Hepatotoxicity in Mice.

H. Jaeschke, 2018, Journal of Agricultural and Food Chemistry.

Novel Therapeutic Approaches against Acetaminophen-induced Liver Injury and Acute Liver Failure.

H. Jaeschke, A. Ramachandran, David S. Umbaugh, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Apoptosis or necrosis in acetaminophen-induced acute liver failure? New insights from mechanistic biomarkers*.

Mitchell R. McGill, H. Jaeschke, 2013, Critical care medicine.

Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients

H. Jaeschke, 2015 .

Building shared experience to advance practical application of pathway-based toxicology: liver toxicity mode-of-action.

Thomas Hartung, Imran Shah, Jennifer Seed, 2014, ALTEX.

Acetaminophen‐induced injury in HepaRG cells: a novel human cell line for studies of drug hepatotoxicity

Mitchell R. McGill, H. Jaeschke, Hui‐min Yan, 2010 .

Targeting the sterile inflammatory response during acetaminophen hepatotoxicity with natural products.

H. Jaeschke, A. Ramachandran, 2021, Toxicology letters.

Nrf2 as a therapeutic target in acetaminophen hepatotoxicity: A case study with sulforaphane.

H. Jaeschke, A. Ramachandran, Y. Etemadi, 2023, Journal of biochemical and molecular toxicology.

Title Page Central Mechanisms of Acetaminophen Hepatotoxicity: Mitochondrial Dysfunction by Protein Adducts and Oxidant Stress

H. Jaeschke, A. Ramachandran, 2023 .

Mechanisms and in vitro models of drug-induced cholestasis

M. Vinken, H. Jaeschke, P. Annaert, 2019, Archives of Toxicology.

Heme oxygenase-1 induction in hepatocytes and non-parenchymal cells protects against liver injury during endotoxemia

H. Jaeschke, A. Farhood, M. Bajt, 2004, Comparative hepatology.

Benzyl Alcohol: A novel treatment for acetaminophen overdose?

H. Jaeschke, Kuo Du, 2015, Hepatology.

Cell adhesion and migration. III. Leukocyte adhesion and transmigration in the liver vasculature.

H. Jaeschke, C. Smith, 1997, The American journal of physiology.

Chemokines and liver inflammation: The battle between pro‐ and anti‐inflammatory mediators

H. Jaeschke, 1997, Hepatology.

Hepatocellular antifreeze carrier

C. Trautwein, J. Boyer, T. Roskams, 2003 .

Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy.

H. Jaeschke, B. Copple, J. Luyendyk, 2014, Journal of hepatology.

Acetaminophen knocks on death's door and receptor interacting protein 1 kinase answers

G. Gores, H. Jaeschke, M. E. Guicciardi, 2015, Hepatology.

Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity

Mitchell R. McGill, H. Jaeschke, Kuo Du, 2015, Expert opinion on drug metabolism & toxicology.

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity.

H. Jaeschke, J. Lemasters, C. Saito, 2010, Toxicology and applied pharmacology.

Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives.

H. Jaeschke, A. Ramachandran, J. Akakpo, 2018, Journal of clinical and translational research.

Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans

Mitchell R. McGill, H. Jaeschke, Feng Li, 2013, Archives of Toxicology.

Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity

H. Jaeschke, A. Ramachandran, W. Ding, 2018, Archives of Toxicology.

Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity.

Mitchell R. McGill, T. Asselah, H. Jaeschke, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Hyponatremia in patients with acute variceal bleeding treated with terlipressin

David C. Jones, H. Jaeschke, J. Newton, 2011, Hepatology.

Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury

H. Jaeschke, A. Ramachandran, C. Baines, 2011, Free radical research.

The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation.

M. Vinken, H. Jaeschke, A. Farhood, 2013, Toxicology and applied pharmacology.

HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity

Mitchell R. McGill, H. Jaeschke, A. Ramachandran, 2011, Hepatology.

Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J.

H. Jaeschke, M. Bourdi, B. Woolbright, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients

H. Jaeschke, 2015, Digestive Diseases.

Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice

H. Jaeschke, A. Ramachandran, S. Weinman, 2015, Archives of Toxicology.

Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products.

Mitchell R. McGill, H. Jaeschke, A. Ramachandran, 2011, Life sciences.

Reactive nitrogen species in acetaminophen-induced mitochondrial damage and toxicity in mouse hepatocytes: a cautionary note on the impact of cell culture conditions.

H. Jaeschke, A. Ramachandran, Hui‐min Yan, 2010, Chemical research in toxicology.

III. Leukocyte adhesion and transmigration in the liver vasculature.

H. Jaeschke, C. Smith, 1997, American journal of physiology. Gastrointestinal and liver physiology.

Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis

Mitchell R. McGill, V. Ambros, Rosalind C. Lee, 2014, Proceedings of the National Academy of Sciences.

Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis

H. Jaeschke, Tiangang Li, B. Bruinsma, 2018, Journal of clinical and translational research.

Direct Amplification of TF (Tissue Factor).

H. Jaeschke, J. Luyendyk, M. Olyaee, 2019, Arteriosclerosis, thrombosis, and vascular biology.

Lysosomal iron mobilization and induction of the mitochondrial permeability transition in acetaminophen-induced toxicity to mouse hepatocytes.

H. Jaeschke, J. Lemasters, Jae‐Sung Kim, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo

H. Jaeschke, A. Farhood, C. Smith, 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice.

H. Jaeschke, B. Woolbright, M. Bajt, 2013, Toxicology and applied pharmacology.

Mechanisms of immune-mediated liver injury.

D. Adams, H. Jaeschke, S. Ramaiah, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Critical review of resveratrol in xenobiotic-induced hepatotoxicity.

Mitchell R. McGill, H. Jaeschke, Kuo Du, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Serum complement mediates endotoxin-induced cysteinyl leukotriene formation in rats in vivo.

H. Jaeschke, S. Gaskell, M. Raftery, 1992, The American journal of physiology.

Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity.

Mitchell R. McGill, H. Jaeschke, K. Dorko, 2015, Journal of clinical and translational research.

Lack of direct cytotoxicity of extracellular ATP against hepatocytes: role in the mechanism of acetaminophen hepatotoxicity

Mitchell R. McGill, H. Jaeschke, K. Dorko, 2015, Journal of clinical and translational research.

High-Dose Acetaminophen with Concurrent CYP2E1 Inhibition Has Profound Anticancer Activity without Liver Toxicity

H. Jaeschke, J. Akakpo, Pavani Pingali, 2023, The Journal of Pharmacology and Experimental Therapeutics.

The chemokine CXCL14 is a novel early prognostic biomarker for poor outcome in acetaminophen-induced acute liver failure

H. Jaeschke, A. Ramachandran, David S. Umbaugh, 2023, Hepatology.

Proteomics Indicates Lactate Dehydrogenase is Prognostic in Acetaminophen-induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways.

William M. Lee, Mitchell R. McGill, J. Dranoff, 2022, Toxicological sciences : an official journal of the Society of Toxicology.