A. Ramachandran

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Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

Mitchell R. McGill, H. Jaeschke, A. Ramachandran, 2012, Drug metabolism reviews.

Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice

H. Jaeschke, A. Ramachandran, Nga T. Nguyen, 2021, Archives of Toxicology.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Adam S. Hayward, C. Meyer, S. Dooley, 2013, Archives of Toxicology.

Osteopontin is an initial mediator of inflammation and liver injury during obstructive cholestasis after bile duct ligation in mice.

Hartmut Jaeschke, H. Jaeschke, A. Ramachandran, 2014, Toxicology letters.

Pancreatic exocrine insufficiency: Comparing fecal elastase 1 with 72-h stool for fecal fat estimation

A. Ramachandran, A. Dutta, R. Kurien, 2016, Indian Journal of Gastroenterology.

Pregnancy-related liver disorders.

A. Ramachandran, A. Goel, K. Jamwal, 2014, Journal of clinical and experimental hepatology.

Environmental Liver Toxins

H. Jaeschke, A. Ramachandran, J. Akakpo, 2019, Encyclopedia of Environmental Health.

Full breastfeeding protection against common enteric bacteria and viruses: results from the MAL-ED cohort study

Mark A. Miller, G. Kang, E. Svensen, 2021, The American journal of clinical nutrition.

Mechanisms of toxicity of Cleistanthus collinus: Vacuolar ATPases are a putative target

A. Ramachandran, A. Manickam, A. A. Lourthuraj, 2011, Clinical toxicology.

Fatty acids influence binding of cobalt to serum albumin in patients with fatty liver.

A. Ramachandran, G. Kurian, K. Balasubramanian, 2008, Biochimica et biophysica acta.

Cleistanthus collinus poisoning affects mitochondrial respiration and induces oxidative stress in the rat kidney

A. Ramachandran, A. Venkatraman, A. Manickam, 2019, Toxicology mechanisms and methods.

Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury.

H. Jaeschke, A. Ramachandran, A. Farhood, 2015, Toxicology and applied pharmacology.

Mechanisms of the interaction of nitroxyl with mitochondria.

A. Ramachandran, P. Brookes, V. Darley-Usmar, 2004, The Biochemical journal.

A mitochondrial journey through acetaminophen hepatotoxicity.

H. Jaeschke, A. Ramachandran, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Acetaminophen hepatotoxicity: A mitochondrial perspective.

H. Jaeschke, A. Ramachandran, 2019, Advances in pharmacology.

Invited Review Acetaminophen Toxicity: Novel Insights Into Mechanisms and Future Perspectives

H. Jaeschke, A. Ramachandran, 2018 .

Pathophysiological relevance of proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.

Mitchell R. McGill, H. Jaeschke, A. Ramachandran, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Influences on catch-up growth using relative versus absolute metrics: evidence from the MAL-ED cohort study

Mark A. Miller, G. Kang, E. Svensen, 2020, BMC Public Health.

Retinoid metabolism in the small intestine during development of liver cirrhosis

A. Ramachandran, A. Pulimood, K. Balasubramanian, 2009, Journal of gastroenterology and hepatology.

Oxidized LDL induces mitochondrially associated reactive oxygen/nitrogen species formation in endothelial cells.

A. Ramachandran, A. Landar, V. Darley-Usmar, 2005, American journal of physiology. Heart and circulatory physiology.

Novel Therapeutic Approaches against Acetaminophen-induced Liver Injury and Acute Liver Failure.

H. Jaeschke, A. Ramachandran, David S. Umbaugh, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Oxidized low density lipoprotein induces mitochondrially associated reactive oxygen / nitrogen species formation in endothelial cells

A. Ramachandran, A. Landar, V. Darley-Usmar, 2005 .

Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity.

H. Jaeschke, A. Ramachandran, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Intestinal Mitochondrial Dysfunction in Surgical Stress 1

A. Ramachandran, K. A. Balasubramanian, S. Patra, 2001 .

Intestinal mitochondrial dysfunction in surgical stress.

A. Ramachandran, K. Balasubramanian, S. Patra, 2001, The Journal of surgical research.

Epidemiology and Impact of Campylobacter Infection in Children in 8 Low-Resource Settings: Results From the MAL-ED Study

Mark A. Miller, G. Kang, E. Svensen, 2016, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Endothelial NOS-dependent activation of c-Jun NH(2)- terminal kinase by oxidized low-density lipoprotein.

H. Jo, A. Ramachandran, Y. Go, 2001, American journal of physiology. Heart and circulatory physiology.

Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

Hartmut Jaeschke, H. Jaeschke, A. Ramachandran, 2012, Liver international : official journal of the International Association for the Study of the Liver.

Oxidant Stress and Lipid Peroxidation in Acetaminophen Hepatotoxicity.

H. Jaeschke, A. Ramachandran, 2018, Reactive oxygen species.

Mitochondrial ATP synthase inhibition and nitric oxide are involved in muscle weakness that occurs in acute exposure of rats to monocrotophos

A. Ramachandran, A. Oommen, A. Zachariah, 2009, Toxicology mechanisms and methods.

Redox signalling: from nitric oxide to oxidized lipids.

A. Ramachandran, A. Landar, P. Brookes, 2004, Biochemical Society symposium.

Volatile anesthetic preconditioning modulates oxidative stress and nitric oxide in patients undergoing coronary artery bypass grafting

A. Ramachandran, S. Dharmalingam, G. J. Amirtharaj, 2021, Annals of cardiac anaesthesia.

Locally made ready-to-use therapeutic food for treatment of malnutrition: A randomized controlled trial

G. Kang, A. Ramachandran, A. Bose, 2010, Indian pediatrics.

Oxidized low-density lipoprotein and 15-deoxy-delta 12,14-PGJ2 increase mitochondrial complex I activity in endothelial cells.

A. Ramachandran, V. Darley-Usmar, A. Levonen, 2003, American journal of physiology. Heart and circulatory physiology.

Oxidized low-density lipoprotein and 15-deoxy-Δ12,14-PGJ2 increase mitochondrial complex I activity in endothelial cells

A. Ramachandran, V. Darley-Usmar, A. Levonen, 2003 .

Vascular Signaling by Free Radicals Oxidized low-density lipoprotein and 15-deoxy- 12,14 -PGJ2 increase mitochondrial complex I activity in endothelial cells

A. Ramachandran, V. Darley-Usmar, A. Levonen, 2003 .

Inhibition of mitochondrial protein synthesis results in increased endothelial cell susceptibility to nitric oxide-induced apoptosis

A. Ramachandran, V. Darley-Usmar, S. Shiva, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Protease activation during surgical stress in the rat small intestine.

A. Ramachandran, K. Balasubramanian, 2000, The Journal of surgical research.

Oxidative stress-associated hypertension in surgically induced brain injury patients: effects of β-blocker and angiotensin-converting enzyme inhibitor.

A. Ramachandran, S. Adhikary, G. Korula, 2013, The Journal of surgical research.

Oxidative stress in the development of liver cirrhosis: A comparison of two different experimental models

A. Ramachandran, Simmy Thomas, A. Pulimood, 2006, Journal of gastroenterology and hepatology.

Desorption Electrospray Ionization Mass Spectrometry Imaging Allows Spatial Localization of Changes in Acetaminophen Metabolism in the Liver after Intervention with 4-Methylpyrazole.

H. Jaeschke, A. Ramachandran, A. Artigues, 2022, Journal of the American Society for Mass Spectrometry.

Mechanisms of signal transduction mediated by oxidized lipids: the role of the electrophile-responsive proteome.

A. Ramachandran, A. Landar, V. Darley-Usmar, 2004, Biochemical Society transactions.

Nitric oxide prevents anoxia-induced apoptosis in colonic HT29 cells.

A. Ramachandran, M. Madesh, K. Balasubramanian, 1999, Archives of biochemistry and biophysics.

Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: Role of mitochondrial respiratory complexes and heat shock proteins

A. Ramachandran, V. Darley-Usmar, E. Ceaser, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Mitochondrial Dynamics in Drug-Induced Liver Injury

H. Jaeschke, A. Ramachandran, David S. Umbaugh, 2021, Livers.

Lysosomal Instability and Cathepsin B Release during Acetaminophen Hepatotoxicity

Mitchell R. McGill, H. Jaeschke, A. Ramachandran, 2012, Basic & clinical pharmacology & toxicology.

Human Wharton's Jelly-derived mesenchymal stem cells prevent acetaminophen-induced liver injury in a mouse model unlike human dermal fibroblasts

H. Jaeschke, A. Ramachandran, U. Apte, 2022, Archives of Toxicology.

The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice.

H. Jaeschke, A. Ramachandran, J. Lemasters, 2022, Toxicology and applied pharmacology.

4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes

H. Jaeschke, A. Ramachandran, B. Rumack, 2018, Human & experimental toxicology.

Retinoid metabolism during development of liver cirrhosis.

A. Ramachandran, Simmy Thomas, A. Pulimood, 2005, Archives of biochemistry and biophysics.

THE ROLE OF OXIDANT STRESS IN ACETAMINOPHE-INDUCED LIVER INJURY.

H. Jaeschke, A. Ramachandran, 2020, Current opinion in toxicology.

Delayed Administration of N-Acetylcysteine Blunts Recovery After an Acetaminophen Overdose Unlike 4-Methylpyrazole

H. Jaeschke, A. Ramachandran, B. Rumack, 2021, Archives of Toxicology.

LIVER FAILURE AND LIVER DISEASE

A. Ramachandran, Simmy Thomas, A. Pulimood, 2006 .

Spontaneous bacterial peritonitis results in oxidative and nitrosative stress in ascitic fluid

A. Ramachandran, G. Kurian, K. Balasubramanian, 2007, Journal of gastroenterology and hepatology.

Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose

H. Jaeschke, A. Ramachandran, B. Rumack, 2022, Archives of Toxicology.

Mitochondrial Damage and Biogenesis in Acetaminophen-induced Liver Injury.

H. Jaeschke, A. Ramachandran, Nga T. Nguyen, 2019, Liver research.

Establishment of the MAL-ED birth cohort study site in Vellore, Southern India.

G. Kang, A. Ramachandran, A. Bose, 2014, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Dimethylformamide interferes with Coomassie dye staining of proteins on blue native gel electrophoresis.

A. Ramachandran, A. Oommen, V. Raghupathy, 2014, Analytical biochemistry.

Role of Pyroptosis in Acetaminophen-Induced Hepatotoxicity

H. Jaeschke, A. Ramachandran, David S. Umbaugh, 2022, Livers.

Nitric oxide protects the intestine from the damage induced by laparotomy and gut manipulation.

A. Ramachandran, S. Patra, K. A. Balasubramanian, 2001, The Journal of surgical research.

Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products.

Mitchell R. McGill, H. Jaeschke, A. Ramachandran, 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Hepatotoxins

H. Jaeschke, A. Ramachandran, 2019, Encyclopedia of Gastroenterology.

Absence of G1528C mutation in long-chain 3-hydroxyacyl-CoA dehydrogenase in four Indian patients with pregnancy-related liver disease

A. Ramachandran, A. Goel, R. Jose, 2014, Indian Journal of Gastroenterology.

Acetaminophen Toxicity: Novel Insights Into Mechanisms and Future Perspectives.

H. Jaeschke, A. Ramachandran, 2018, Gene expression.

Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity.

Mitchell R. McGill, T. Asselah, H. Jaeschke, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity.

Hartmut Jaeschke, Mitchell R. McGill, H. Jaeschke, 2012, Toxicology and applied pharmacology.

Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products.

Hartmut Jaeschke, Mitchell R. McGill, H. Jaeschke, 2011, Life sciences.

Intestinal mucosal alterations in experimental cirrhosis in the rat: Role of oxygen free radicals

A. Ramachandran, Simmy Thomas, A. Pulimood, 2002, Hepatology.

Use of quantitative molecular diagnostic methods to assess the aetiology, burden, and clinical characteristics of diarrhoea in children in low-resource settings: a reanalysis of the MAL-ED cohort study

Md Iqbal Hossain, Mark A. Miller, Gagandeep Kang, 2018, The Lancet. Global health.

Use of quantitative molecular diagnostic methods to investigate the effect of enteropathogen infections on linear growth in children in low-resource settings: longitudinal analysis of results from the MAL-ED cohort study

Mark A. Miller, G. Kang, E. Svensen, 2018, The Lancet. Global health.

Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products.

J. Morrow, A. Ramachandran, A. Landar, 2004, The Biochemical journal.

The MAL-ED study: a multinational and multidisciplinary approach to understand the relationship between enteric pathogens, malnutrition, gut physiology, physical growth, cognitive development, and immune responses in infants and children up to 2 years of age in resource-poor environments.

Robert E Black, Mark A. Miller, Gagandeep Kang, 2014, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Oxidative Stress and Acute Hepatic Injury.

H. Jaeschke, A. Ramachandran, 2018, Current opinion in toxicology.

Mild Whole-Body Heat Stress Alters Retinoid Metabolism in the Rat Small Intestine

A. Ramachandran, Simmy Thomas, K. Balasubramanian, 2006, Digestive Diseases and Sciences.

Mitochondrial Membrane Potential Drives Early Change in Mitochondrial Morphology After Acetaminophen Exposure.

H. Jaeschke, A. Ramachandran, Nga T. Nguyen, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Liver injury in acute fatty liver of pregnancy: Possible link to placental mitochondrial dysfunction and oxidative stress

A. Ramachandran, B. Ramakrishna, M. Mathai, 2010, Hepatology.

Acute fatty liver of pregnancy: an update on mechanisms

A. Ramachandran, A. Goel, C. Eapen, 2011, Obstetric medicine.

Apoptosis in the intestinal epithelium: Its relevance in normal and pathophysiological conditions

A. Ramachandran, M. Madesh, K. Balasubramanian, 2000, Journal of gastroenterology and hepatology.

Intestinal mucosal alterations in rats with carbon tetrachloride‐induced cirrhosis: Changes in glycosylation and luminal bacteria

G. Kang, A. Ramachandran, Simmy Thomas, 2006, Hepatology.

Attenuation of intestinal ischemia/reperfusion injury with sodium nitroprusside: studies on mitochondrial function and lipid changes.

A. Ramachandran, M. Madesh, A. Pulimood, 2000, Biochimica et biophysica acta.

Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential

H. Jaeschke, A. Ramachandran, Kuo Du, 2016, Redox biology.

Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury

H. Jaeschke, A. Ramachandran, C. Baines, 2011, Free radical research.

Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives

H. Jaeschke, A. Ramachandran, J. Akakpo, 2018, Journal of clinical and translational research.

Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology

H. Jaeschke, A. Ramachandran, 2017, Journal of clinical and translational research.

Chapter 6 – Acetaminophen

H. Jaeschke, A. Ramachandran, 2017 .

Acetaminophen Hepatotoxicity

H. Jaeschke, A. Ramachandran, 2019, Seminars in Liver Disease.

Reactive oxygen species in the normal and acutely injured liver.

H. Jaeschke, A. Ramachandran, 2011, Journal of hepatology.

Intestinal dysfunction in liver cirrhosis: Its role in spontaneous bacterial peritonitis

A. Ramachandran, K. A. Balasubramanian, 2001, Journal of gastroenterology and hepatology.

The role of apoptosis in acetaminophen hepatotoxicity.

H. Jaeschke, A. Ramachandran, A. Farhood, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Mitochondria, nitric oxide, and cardiovascular dysfunction.

A. Ramachandran, P. Brookes, V. Darley-Usmar, 2002, Free radical biology & medicine.

HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity

Hartmut Jaeschke, Mitchell R. McGill, H. Jaeschke, 2011, Hepatology.

Adam S. Hayward, C. Meyer, S. Dooley, 2013, Archives of Toxicology.

Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen‐induced hepatocyte necrosis in mice

Mitchell R. McGill, H. Jaeschke, A. Ramachandran, 2013, Hepatology.

Low dose aspirin prevents duodenoesophageal reflux induced mucosal changes in wistar rat esophagus by MAP kinase mediated pathways.

A. Ramachandran, A. Korula, B. Selvan, 2012, International journal of surgery.

Mice deficient in pyruvate dehydrogenase kinase 4 are protected against acetaminophen-induced hepatotoxicity.

H. Jaeschke, A. Ramachandran, B. Woolbright, 2019, Toxicology and applied pharmacology.

Mitochondrial Protein Adduct and Superoxide Generation are Prerequisites for Early Activation of c-Jun N-terminal Kinase within the Cytosol after an Acetaminophen Overdose in Mice.

H. Jaeschke, A. Ramachandran, Nga T. Nguyen, 2020, Toxicology letters.

Activation of the adenosine A2B receptor even beyond the therapeutic window of N-acetylcysteine accelerates liver recovery after an Acetaminophen overdose.

H. Jaeschke, A. Ramachandran, Giselle Sánchez-Guerrero, 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls

H. Jaeschke, A. Ramachandran, Nga T. Nguyen, 2021, Acta pharmaceutica Sinica. B.

Letter to the Editor: Does c‐Jun N‐Terminal Kinase Regulate Acetaminophen Hepatotoxicity by Modulating Nuclear Factor Erythroid 2–Related Factor 2–Dependent Genes or Mitochondrial Oxidant Stress?

H. Jaeschke, A. Ramachandran, 2020 .

Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity

H. Jaeschke, A. Ramachandran, W. Ding, 2018, Archives of Toxicology.

Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.

H. Jaeschke, A. Ramachandran, A. Farhood, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity.

H. Jaeschke, A. Ramachandran, S. Weinman, 2011, Toxicology and applied pharmacology.

Aberrant Niche Signaling in the Etiopathogenesis of Ulcerative Colitis

A. Ramachandran, A. Venkatraman, S. Abbas, 2015, Inflammatory bowel diseases.

Intestinal permeability and inflammation mediate the association between nutrient density of complementary foods and biochemical measures of micronutrient status in young children: results from the MAL-ED study

Mark A. Miller, G. Kang, E. Svensen, 2019, The American journal of clinical nutrition.

Mechanisms of Acetaminophen Hepatotoxicity: Cell Death Signaling Mechanisms in Hepatocytes

H. Jaeschke, A. Ramachandran, M. Bajt, 2018 .

Plasma von Willebrand factor levels predict in-hospital survival in patients with acute-on-chronic liver failure

A. Ramachandran, E. Elias, I. Mackie, 2016, Indian Journal of Gastroenterology.

Spatial Reconstruction of the Early Hepatic Transcriptomic Landscape after an Acetaminophen Overdose using Single-cell RNA Sequencing.

H. Jaeschke, A. Ramachandran, David S. Umbaugh, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Activation of c-Jun N-Terminal Kinase and Apoptosis in Endothelial Cells Mediated by Endogenous Generation of Hydrogen Peroxide

S. Parthasarathy, H. Jo, A. Ramachandran, 2002, Biological chemistry.

The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes.

H. Jaeschke, A. Ramachandran, J. Lemasters, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Acetaminophen-induced apoptosis: Facts versus fiction

H. Jaeschke, A. Ramachandran, 2020, Journal of clinical and translational research.

Emerging and established modes of cell death during acetaminophen-induced liver injury

H. Jaeschke, A. Ramachandran, W. Ding, 2019, Archives of Toxicology.

Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.

H. Jaeschke, A. Ramachandran, P. Krishnamurthy, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Plasma Citrulline, Glycans, and Hydrogen Sulfide in Patients With Acute Pancreatitis: Possible Markers of Intestinal Damage

A. Ramachandran, A. Joseph, K. Balasubramanian, 2016, Pancreas.

Mitochondrial electron transport chain complex dysfunction in the colonic mucosa in ulcerative colitis

A. Ramachandran, B. Ramakrishna, S. Santhanam, 2012, Inflammatory bowel diseases.

Oxidant Stress and Drug-Induced Hepatotoxicity

Mitchell R. McGill, H. Jaeschke, A. Ramachandran, 2014 .

4-methylpyrazole protects against acetaminophen-induced acute kidney injury.

H. Jaeschke, A. Ramachandran, B. Rumack, 2020, Toxicology and applied pharmacology.

Cleistanthus collinus induces type I distal renal tubular acidosis and type II respiratory failure in rats

A. Ramachandran, Praghalathan Kanthakumar, A. A. Lourthuraj, 2010, Indian journal of pharmacology.

Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose

H. Jaeschke, A. Ramachandran, B. Rumack, 2022, Archives of Toxicology.

Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase.

H. Jaeschke, A. Ramachandran, B. Rumack, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

PGAM5: a new player in immune-mediated liver injury

H. Jaeschke, A. Ramachandran, 2016, Gut.

Nitric oxide production in acute gastroenteritis in Indian children.

G. Kang, A. Ramachandran, R. Sarkar, 2009, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Role of Oxidative and Nitrosative Stress in Pathophysiology of Toxic Epidermal Necrolysis and Stevens Johnson Syndrome—A Pilot Study

A. Ramachandran, D. Peter, S. Pulimood, 2015, Indian journal of dermatology.

High throughput two‐dimensional blue‐native electrophoresis: A tool for functional proteomics of mitochondria and signaling complexes

Stephen Barnes, A. Ramachandran, S. Barnes, 2002, Proteomics.

Late Protective Effect of Netrin-1 in the Murine Acetaminophen Hepatotoxicity Model.

H. Jaeschke, A. Ramachandran, B. Woolbright, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Role of Oxygen Free Radicals, Nitric Oxide and Mitochondria in Mediating Cardiac Alterations During Liver Cirrhosis Induced by Thioacetamide

A. Ramachandran, A. Venkatraman, A. Pulimood, 2017, Cardiovascular Toxicology.

Novel strategies for the treatment of acetaminophen hepatotoxicity

H. Jaeschke, A. Ramachandran, J. Akakpo, 2020, Expert opinion on drug metabolism & toxicology.

Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice

H. Jaeschke, A. Ramachandran, W. Ding, 2021, Archives of Toxicology.

Experimental Models of Hepatotoxicity for the Testing of Natural Products

A. Ramachandran, H. Jaeschke, H. Jaeschke, 2013 .

Causal Pathways from Enteropathogens to Environmental Enteropathy: Findings from the MAL-ED Birth Cohort Study

Mark A. Miller, G. Kang, E. Svensen, 2017, EBioMedicine.

Ferroptosis and Acetaminophen Hepatotoxicity - Are We Going Down Another Rabbit Hole?

H. Jaeschke, A. Ramachandran, Ola Adelusi, 2021, Gene expression.

Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives

H. Jaeschke, A. Ramachandran, J. Akakpo, 2018, Journal of clinical and translational research.

Enteral glutamine differentially regulates Nrf 2 along the villus‐crypt axis of the intestine to enhance glutathione levels

A. Ramachandran, A. Venkatraman, Archana Kini, 2015, Journal of gastroenterology and hepatology.

Acute liver injury induced by low dose dimethylnitrosamine alters mediators of hepatic vascular flow

A. Ramachandran, A. Goel, A. Venkatraman, 2014, Toxicology reports.

Oxidant Stress and Acetaminophen Hepatotoxicity: Mechanism-Based Drug Development.

H. Jaeschke, A. Ramachandran, 2021, Antioxidants & redox signaling.

Role of extracellular vesicles in release of protein adducts after acetaminophen-induced liver injury in mice and humans.

H. Jaeschke, A. Ramachandran, S. Curry, 2019, Toxicology letters.

Mitochondria in Acetaminophen-Induced Liver Injury and Recovery: A Concise Review

H. Jaeschke, A. Ramachandran, 2023, Livers.

Dose-dependent pleiotropic role of neutrophils during acetaminophen-induced liver injury in male and female mice

H. Jaeschke, A. Ramachandran, David S. Umbaugh, 2023, Archives of Toxicology.

Recovered Hepatocytes Promote Macrophage Apoptosis through CXCR4 after Acetaminophen-Induced Liver Injury in Mice.

H. Jaeschke, A. Ramachandran, David S. Umbaugh, 2022, Toxicological Sciences.

Von-Willebrand factor: A biomarker to predict in-hospital survival in patients with severe and very severe alcoholic hepatitis

A. Ramachandran, E. Elias, S. Nair, 2020 .

ADAMTS13 missense variants associated with defective activity and secretion of ADAMTS13 in a patient with non-cirrhotic portal hypertension

N. Thomas, A. Ramachandran, E. Elias, 2017, Indian Journal of Gastroenterology.

Arsenicosis, possibly from contaminated groundwater, associated with noncirrhotic intrahepatic portal hypertension

J. J. Fleming, A. Ramachandran, E. Elias, 2016, Indian Journal of Gastroenterology.

Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice

H. Jaeschke, A. Ramachandran, S. Weinman, 2015, Archives of Toxicology.

Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation.

Mitchell R. McGill, H. Jaeschke, A. Ramachandran, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

ADAMTS 13 missense variants associated with defective activity and secretion of ADAMTS 13 in a patient with non-cirrhotic portal hypertension

Banumathi, Eapen, N. Thomas, 2017 .

Response to the opinion letter entitled Role of Ferroptosis in Acetaminophen Hepatotoxicity by Yamada et al.

H. Jaeschke, A. Ramachandran, 2020, Archives of Toxicology.

Early Life Child Micronutrient Status, Maternal Reasoning, and a Nurturing Household Environment have Persistent Influences on Child Cognitive Development at Age 5 years: Results from MAL-ED

Mark A. Miller, G. Kang, E. Svensen, 2019, The Journal of nutrition.

Pleiotropic Roles of Platelets and Neutrophils in Cell Death and Recovery During Acetaminophen Hepatotoxicity

H. Jaeschke, A. Ramachandran, 2020, Hepatology.

Putative Effects of an Orally Administered Anti-TLR4 Antibody on Gut Microbiota and Acetaminophen Hepatotoxicity in Mice

H. Jaeschke, A. Ramachandran, 2022, Microbiology spectrum.

Novel Therapeutic Approaches against Acetaminophen-induced Liver Injury and Acute Liver Failure.

H. Jaeschke, A. Ramachandran, David S. Umbaugh, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Targeting the sterile inflammatory response during acetaminophen hepatotoxicity with natural products.

H. Jaeschke, A. Ramachandran, 2021, Toxicology letters.

Epidemiology and Impact of Campylobacter Infection in Children in 8 Low-Resource Settings: Results From the MAL-ED Study

Mark A. Miller, G. Kang, E. Svensen, 2016, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Nrf2 as a therapeutic target in acetaminophen hepatotoxicity: A case study with sulforaphane

H. Jaeschke, A. Ramachandran, Y. Etemadi, 2023, Journal of biochemical and molecular toxicology.

Title Page Central Mechanisms of Acetaminophen Hepatotoxicity: Mitochondrial Dysfunction by Protein Adducts and Oxidant Stress

H. Jaeschke, A. Ramachandran, 2023 .

Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives.

H. Jaeschke, A. Ramachandran, J. Akakpo, 2018, Journal of Clinical and Translational Research.