D. Donnelly

发表

Modeling α‐helical transmembrane domains: The calculation and use of substitution tables for lipid‐facing residues

John P. Overington, T. Blundell, D. Donnelly, 1993, Protein science : a publication of the Protein Society.

Environment‐specific amino acid substitution tables: Tertiary templates and prediction of protein folds

John P. Overington, T. Blundell, A. Sali, 1992, Protein science : a publication of the Protein Society.

The arrangement of the transmembrane helices in the secretin receptor family of G‐protein‐coupled receptors

D. Donnelly, 1997, FEBS letters.

Modelling α-helical transmembrane domains

D. Donnelly, 1993 .

Modelling alpha-helical transmembrane domains.

D. Donnelly, 1993, Biochemical Society transactions.

The prediction and orientation of alpha-helices from sequence alignments: the combined use of environment-dependent substitution tables, Fourier transform methods and helix capping rules.

John P. Overington, T L Blundell, J P Overington, 1994, Protein engineering.

Seven-helix receptors: structure and modelling

D. Donnelly, J. Findlay, 1994 .

The major determinant of exendin‐4/glucagon‐like peptide 1 differential affinity at the rat glucagon‐like peptide 1 receptor N‐terminal domain is a hydrogen bond from SER‐32 of exendin‐4

D. Donnelly, N. Nasr, R. Mann, 2010, British journal of pharmacology.

The glucagon‐like peptide‐1 receptor binding site for the N‐terminus of GLP‐1 requires polarity at Asp198 rather than negative charge

D. Donnelly, R. López de Maturana, R. López de Maturana, 2002, FEBS letters.

The Isolated N-terminal Domain of the Glucagon-like Peptide-1 (GLP-1) Receptor Binds Exendin Peptides with Much Higher Affinity than GLP-1*

D. Donnelly, R. Rudolph, R. López de Maturana, 2003, The Journal of Biological Chemistry.

The positive charge at Lys‐288 of the glucagon‐like peptide‐1 (GLP‐1) receptor is important for binding the N‐terminus of peptide agonists

D. Donnelly, S. Al-Sabah, 2003, FEBS letters.

Met-204 and Tyr-205 are together important for binding GLP-1 receptor agonists but not their N-terminally truncated analogues.

D. Donnelly, J. Findlay, F. Abidi, 2004, Protein and peptide letters.

MTSEA prevents ligand binding to the human melanocortin‐4 receptor by modification of cysteine 130 in transmembrane helix 3

D. Donnelly, J. Findlay, S. Cheetham, 2005, FEBS letters.

Functional expression of glucose-dependent insulinotropic polypeptide receptors is coupled to differentiation in a human adipocyte model

A. Balmforth, D. Donnelly, M. Wabitsch, 2008, International Journal of Obesity.

Peptide binding at the GLP-1 receptor.

D. Donnelly, F. Abidi, N. Nasr, 2007, Biochemical Society transactions.

Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications.

D. Donnelly, J. Findlay, Stuart Maudsley, 1999, The Biochemical journal.

The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor.

D. Donnelly, J. Findlay, N. Bhogal, 1996, The Journal of Biological Chemistry.

The GIP Receptor Displays Higher Basal Activity than the GLP-1 Receptor but Does Not Recruit GRK2 or Arrestin3 Effectively

D. Donnelly, M. Bünemann, C. Krasel, 2014, PloS one.

New variants and in silico analyses in GRK1 associated Oguchi disease

Rachel L. Taylor, C. Rivolta, D. Donnelly, 2020, Human mutation.

New pathogenic variants and insights into pathogenic mechanisms in GRK1-related Oguchi disease

Rachel L. Taylor, C. Rivolta, D. Donnelly, 2020, bioRxiv.

Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74

M. Wigglesworth, D. Donnelly, D. Poyner, 2010, Biochemical and biophysical research communications.

This is a repository copy of A mechanism for agonist activation of the glucagon-like peptide-1 (GLP-1) receptor through modelling

E. Paci, D. Donnelly, Carla Gómez Santiago, 2019 .

A mechanism for agonist activation of the glucagon-like peptide-1 (GLP-1) receptor through modelling & molecular dynamics.

E. Paci, D. Donnelly, Carla Gómez Santiago, 2018, Biochemical and biophysical research communications.

Conformational induction is the key process for activation of the AT1 receptor.

A. Balmforth, D. Donnelly, P. Warburton, 2006, Biochemical pharmacology.

Structure of G-protein-linked receptors.

T. Attwood, D. Donnelly, N. Bhogal, 1993, Biochemical Society transactions.

Ligand-Receptor Interactions at the Parathyroid Hormone Receptors: Subtype Binding Selectivity Is Mediated via an Interaction between Residue 23 on the Ligand and Residue 41 on the Receptor

M. Wigglesworth, D. Donnelly, R. Mann, 2008, Molecular Pharmacology.

N-terminal phosphorylation of parathyroid hormone (PTH) abolishes its receptor activity.

D. Donnelly, J. Balbach, Amit Kumar, 2014, ACS chemical biology.

The relationship between the agonist‐induced activation and desensitization of the human tachykinin NK2 receptor expressed in Xenopus oocytes

D. Donnelly, J. Findlay, Stuart Maudsley, 1998, British journal of pharmacology.

The structure and function of the glucagon‐like peptide‐1 receptor and its ligands

D. Donnelly, Dan Donnelly, 2012, British journal of pharmacology.

Glucagon-Like Peptide-1 and Its Class B G Protein–Coupled Receptors: A Long March to Therapeutic Successes

P. Sexton, D. Donnelly, C. de Graaf, 2016, Pharmacological Reviews.

A three-dimensional model of the Photosystem II reaction centre of Pisum sativum

T. Blundell, D. Donnelly, S. Ruffle, 1992, Photosynthesis Research.

A Non-peptidic photoactivatable antagonist for mapping the antagonist binding site of the tachykinin NK2 receptor

C. Fishwick, D. Donnelly, J. Findlay, 1996 .

Interactions of the Melanocortin-4 Receptor with the Peptide Agonist NDP-MSH

D. Donnelly, J. Findlay, G. Kinsella, 2010, Journal of molecular biology.

The evolution and structure of aminergic G protein-coupled receptors.

T L Blundell, J B Findlay, T. Blundell, 1994, Receptors & channels.

An analysis of the periodicity of conserved residues in sequence alignments of G‐protein coupled receptors

T. Blundell, D. Donnelly, J. Saunders, 1989, FEBS letters.

Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23–60 of the calcitonin receptor-like receptor

D. Donnelly, D. Poyner, J. Barwell, 2010, Peptides.

A model for receptor–peptide binding at the glucagon‐like peptide‐1 (GLP‐1) receptor through the analysis of truncated ligands and receptors

D. Donnelly, S. Al-Sabah, 2003, British journal of pharmacology.

Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket

D. Donnelly, Rosalind J. Mann, Suleiman Al-Sabah, 2010, Peptides.

PATTERNS OF SEQUENCE VARIATION IN FAMILIES OF HOMOLOGOUS PROTEINS

John P. Overington, Andrej Sali, Tom L. Blundell, 1991 .

The Conformational Change Responsible for AT1 Receptor Activation Is Dependent upon Two Juxtaposed Asparagine Residues on Transmembrane Helices III and VII*

S. Ball, A. Balmforth, D. Donnelly, 1997, The Journal of Biological Chemistry.

The Superfamily: Molecular Modelling

D. Donnelly, J. Findlay, 1993 .

High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5

M. Wigglesworth, D. Donnelly, C. Reynolds, 2017, Biochemical pharmacology.

A salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity

M. Wigglesworth, D. Donnelly, R. E. Weaver, 2014, Peptides.

Predicting the point at which transmembrane helices protrude from the bilayer: a model of the antenna complexes from photosynthetic bacteria.

D. Donnelly, R. Cogdell, 1993, Protein engineering.

The primary ligand-binding interaction at the GLP-1 receptor is via the putative helix of the peptide agonists.

D. Donnelly, S. Al-Sabah, 2004, Protein and peptide letters.

Fluorescence probes for the study of acetylcholine receptor function.

J. González-Ros, D. Donnelly, J. Ferragut, 1984, Biophysical journal.