U. Bredberg

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Metabolic Stability for Drug Discovery and Development

C. Masimirembwa, U. Bredberg, T. Andersson, 2003, Clinical pharmacokinetics.

Prediction of Human Pharmacokinetics and Pharmacodynamics

U. Bredberg, 2018, Early Drug Development.

A new human retrovirus isolate of West African origin (SBL-6669) and its relationship to HTLV-IV, LAV-II, and HTLV-IIIB.

U. Bredberg, J. Albert, F. Chiodi, 1987, AIDS research and human retroviruses.

Improved Measurement of Drug Exposure in the Brain Using Drug-Specific Correction for Residual Blood

Ulf Bredberg, Margareta Hammarlund-Udenaes, Brian Middleton, 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

In Vitro Methods for Estimating Unbound Drug Concentrations in the Brain Interstitial and Intracellular Fluids

U. Bredberg, M. Hammarlund-Udenaes, M. Fridén, 2007, Drug Metabolism and Disposition.

Methodologies to assess brain drug delivery in lead optimization.

U. Bredberg, M. Hammarlund-Udenaes, M. Fridén, 2009, Current topics in medicinal chemistry.

The protective action of chlormethiazole against ischaemia‐induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity

U. Bredberg, A. Cross, A. R. Green, 1995, British journal of pharmacology.

Kinetics of Methysergide and its Main Metabolite, Methylergometrine, in Man

U. Bredberg, L. Paalzow, P. Tfelt-Hansen, 1985 .

Pharmacokinetics of methysergide and its metabolite methylergometrine in the rat.

U. Bredberg, L. Paalzow, 1990, Drug metabolism and disposition: the biological fate of chemicals.

Mathematical description of the concentration of oxytetracycline and penicillin-G in tissue cages in calves as related to the serum concentration.

U. Bredberg, J. Luthman, B. Bengtsson, 1992, Journal of veterinary pharmacology and therapeutics.

PKPD awareness is vital if we are to attempt to relate preclinical results to the acute and long term consequences in humans

U. Bredberg, P. Gillberg, J. Gabrielsson, 2009 .

Absorption, distribution, metabolism, and excretion of ximelagatran, an oral direct thrombin inhibitor, in rats, dogs, and humans.

U. Bredberg, K. Hoffmann, U. Eriksson, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Discovery of AZD8165 – a clinical candidate from a novel series of neutral thrombin inhibitors

U. Bredberg, J. Bergman, S. Pehrsson, 2016 .

A new oral anticoagulant: the 50-year challenge

Ingemar Nilsson, Ulf Bredberg, David Gustafsson, 2004, Nature Reviews Drug Discovery.

The direct thrombin inhibitor melagatran and its oral prodrug H 376/95: intestinal absorption properties, biochemical and pharmacodynamic effects.

A Abrahamsson, U Bredberg, U. Bredberg, 2001, Thrombosis research.

Stereoselective metabolism by human liver CYP enzymes of a substituted benzimidazole.

U. Bredberg, T. Andersson, L. Weidolf, 2000, Drug metabolism and disposition: the biological fate of chemicals.

The Multiple Depletion Curves Method Provides Accurate Estimates of Intrinsic Clearance (CLint), Maximum Velocity of the Metabolic Reaction (Vmax), and Michaelis Constant (Km): Accuracy and Robustness Evaluated through Experimental Data and Monte Carlo Simulations

H. Lennernäs, U. Bredberg, T. Andersson, 2009, Drug Metabolism and Disposition.

Pharmacokinetics of methysergide and its metabolite methylergometrine in man

U. Bredberg, L. Paalzow, P. Tfelt-Hansen, 2004, European Journal of Clinical Pharmacology.

Model-based drug discovery: implementation and impact.

Andrew Hughes, Sandra A G Visser, Malin Aurell, 2013, Drug discovery today.

Prediction of drug tissue to plasma concentration ratios using a measured volume of distribution in combination with lipophilicity.

U. Bredberg, M. Ashton, R. Jansson, 2008, Journal of pharmaceutical sciences.

The pharmacokinetics and hepatic disposition of repaglinide in pigs: mechanistic modeling of metabolism and transport.

H. Lennernäs, U. Bredberg, E. Sjögren, 2012, Molecular pharmaceutics.

Long-term Intravenous Infusion in Healkby Volunteers

U. Bredberg, C. Regårdh, U. Eriksson, 2006 .

Pharmacokinetics and Arteriovenous Ckvidipine Concentration following a mierences in Short-and a Long-term Intravenous Infusion in Healkby Volunteers

U. Bredberg, C. Regårdh, U. Eriksson, 2006 .

Pharmacokinetics and Arteriovenous Differences in Clevidipine Concentration following a Short- and a Long-term Intravenous Infusion in Healthy Volunteers

U. Bredberg, C. Regårdh, U. Eriksson, 2000, Anesthesiology.

Pharmacokinetics and pharmacodynamics of ximelagatran, a novel oral direct thrombin inhibitor, in young healthy male subjects

Ulf Bredberg, David Gustafsson, U. Bredberg, 2003, European Journal of Clinical Pharmacology.

CLINICAL CASE DEFINITION OF AIDS IN AFRICAN ADULTS

U. Bredberg, K. Pallangyo, F. Mhalu, 1987, The Lancet.

Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids.

Susanne Winiwarter, Ulf Bredberg, Margareta Hammarlund-Udenaes, 2009, Journal of medicinal chemistry.

Measurement of Unbound Drug Exposure in Brain: Modeling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

Ulf Bredberg, Margareta Hammarlund-Udenaes, Fredrik Bergström, 2011, Drug Metabolism and Disposition.

Early integration of pharmacokinetic and dynamic reasoning is essential for optimal development of lead compounds: strategic considerations.

Hugues Dolgos, Johan Gabrielsson, Ulf Bredberg, 2009, Drug discovery today.

Quantifying and Communicating Uncertainty in Preclinical Human Dose-Prediction

P Gennemark, M Sundqvist, A Lundahl, 2015, CPT: pharmacometrics & systems pharmacology.

Pharmacokinetics of Methylergometrine in the Rat: Evidence for Enterohepatic Recirculation by a Linked-Rat Model

Ulf Bredberg, U. Bredberg, L. Paalzow, 2004, Pharmaceutical Research.

Estimation of Bioavailability on a Single Occasion After Semisimultaneous Drug Administration

U. Bredberg, M. Karlsson, 1989, Pharmaceutical Research.

A comparison between the semisimultaneous and the stable isotope techniques for bioavailability estimation of terbutaline in humans

U. Bredberg, M. Karlsson, L. Borgström, 1992, Clinical pharmacology and therapeutics.

Hepatic Disposition of Ximelagatran and Its Metabolites in Pig; Prediction of the Impact of Membrane Transporters Through a Simple Disposition Model

J. Bergquist, H. Lennernäs, U. Bredberg, 2010, Pharmaceutical Research.

Bioavailability estimation by semisimultaneous drug administration: A Monte Carlo simulation study

U. Bredberg, M. Karlsson, 1990, Journal of Pharmacokinetics and Biopharmaceutics.

Regional intestinal absorption and biliary excretion of fluvastatin in the rat: possible involvement of mrp2.

H. Lennernäs, U. Bredberg, A. Ungell, 2004, Molecular pharmaceutics.

Development of a High-Throughput Brain Slice Method for Studying Drug Distribution in the Central Nervous System

Ulf Bredberg, Frederic Ducrozet, Margareta Hammarlund-Udenaes, 2009, Drug Metabolism and Disposition.

In Vitro Methods for Estimating Unbound Drug Concentrations in the Brain Interstitial and Intracellular Fluids

U. Bredberg, M. Hammarlund-Udenaes, M. Fridén, 2007, Drug Metabolism and Disposition.

In vivo evaluation of the semi‐simultaneous method for bioavailability estimation using controlled intravenous infusion as an ‘extravascular’ route of administration

U. Bredberg, M. Karlsson, 1991, Biopharmaceutics & drug disposition.